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1.
  • Aartsen, M. G., et al. (author)
  • IceCube-Gen2 : the window to the extreme Universe
  • 2021
  • In: Journal of Physics G. - : Institute of Physics Publishing (IOPP). - 0954-3899 .- 1361-6471. ; 48:6
  • Journal article (peer-reviewed)abstract
    • The observation of electromagnetic radiation from radio to gamma-ray wavelengths has provided a wealth of information about the Universe. However, at PeV (10(15) eV) energies and above, most of the Universe is impenetrable to photons. New messengers, namely cosmic neutrinos, are needed to explore the most extreme environments of the Universe where black holes, neutron stars, and stellar explosions transform gravitational energy into non-thermal cosmic rays. These energetic particles have millions of times higher energies than those produced in the most powerful particle accelerators on Earth. As neutrinos can escape from regions otherwise opaque to radiation, they allow an unique view deep into exploding stars and the vicinity of the event horizons of black holes. The discovery of cosmic neutrinos with IceCube has opened this new window on the Universe. IceCube has been successful in finding first evidence for cosmic particle acceleration in the jet of an active galactic nucleus. Yet, ultimately, its sensitivity is too limited to detect even the brightest neutrino sources with high significance, or to detect populations of less luminous sources. In this white paper, we present an overview of a next-generation instrument, IceCube-Gen2, which will sharpen our understanding of the processes and environments that govern the Universe at the highest energies. IceCube-Gen2 is designed to: (a) Resolve the high-energy neutrino sky from TeV to EeV energies (b) Investigate cosmic particle acceleration through multi-messenger observations (c) Reveal the sources and propagation of the highest energy particles in the Universe (d) Probe fundamental physics with high-energy neutrinos IceCube-Gen2 will enhance the existing IceCube detector at the South Pole. It will increase the annual rate of observed cosmic neutrinos by a factor of ten compared to IceCube, and will be able to detect sources five times fainter than its predecessor. Furthermore, through the addition of a radio array, IceCube-Gen2 will extend the energy range by several orders of magnitude compared to IceCube. Construction will take 8 years and cost about $350M. The goal is to have IceCube-Gen2 fully operational by 2033. IceCube-Gen2 will play an essential role in shaping the new era of multi-messenger astronomy, fundamentally advancing our knowledge of the high-energy Universe. This challenging mission can be fully addressed only through the combination of the information from the neutrino, electromagnetic, and gravitational wave emission of high-energy sources, in concert with the new survey instruments across the electromagnetic spectrum and gravitational wave detectors which will be available in the coming years.
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2.
  • Flannick, Jason, et al. (author)
  • Data Descriptor : Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
  • 2017
  • In: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 4
  • Journal article (peer-reviewed)abstract
    • To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (> 80% of low-frequency coding variants in similar to ~82 K Europeans via the exome chip, and similar to ~90% of low-frequency non-coding variants in similar to ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
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3.
  • Fuchsberger, Christian, et al. (author)
  • The genetic architecture of type 2 diabetes
  • 2016
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 536:7614, s. 41-47
  • Journal article (peer-reviewed)abstract
    • The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.
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4.
  • Abbasi, R., et al. (author)
  • A convolutional neural network based cascade reconstruction for the IceCube Neutrino Observatory
  • 2021
  • In: Journal of Instrumentation. - : Institute of Physics Publishing (IOPP). - 1748-0221. ; 16:7
  • Journal article (peer-reviewed)abstract
    • Continued improvements on existing reconstruction methods are vital to the success of high-energy physics experiments, such as the IceCube Neutrino Observatory. In IceCube, further challenges arise as the detector is situated at the geographic South Pole where computational resources are limited. However, to perform real-time analyses and to issue alerts to telescopes around the world, powerful and fast reconstruction methods are desired. Deep neural networks can be extremely powerful, and their usage is computationally inexpensive once the networks are trained. These characteristics make a deep learning-based approach an excellent candidate for the application in IceCube. A reconstruction method based on convolutional architectures and hexagonally shaped kernels is presented. The presented method is robust towards systematic uncertainties in the simulation and has been tested on experimental data. In comparison to standard reconstruction methods in IceCube, it can improve upon the reconstruction accuracy, while reducing the time necessary to run the reconstruction by two to three orders of magnitude.
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5.
  • Abbasi, R., et al. (author)
  • A Search for Coincident Neutrino Emission from Fast Radio Bursts with Seven Years of IceCube Cascade Events
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 1538-4357 .- 0004-637X. ; 946:2
  • Journal article (peer-reviewed)abstract
    • This paper presents the results of a search for neutrinos that are spatially and temporally coincident with 22 unique, nonrepeating fast radio bursts (FRBs) and one repeating FRB (FRB 121102). FRBs are a rapidly growing class of Galactic and extragalactic astrophysical objects that are considered a potential source of high-energy neutrinos. The IceCube Neutrino Observatory's previous FRB analyses have solely used track events. This search utilizes seven years of IceCube cascade events which are statistically independent of track events. This event selection allows probing of a longer range of extended timescales due to the low background rate. No statistically significant clustering of neutrinos was observed. Upper limits are set on the time-integrated neutrino flux emitted by FRBs for a range of extended time windows.
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6.
  • Abbasi, R., et al. (author)
  • A Search for IceCube Sub-TeV Neutrinos Correlated with Gravitational-wave Events Detected By LIGO/Virgo
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 1538-4357 .- 0004-637X. ; 959:2
  • Journal article (peer-reviewed)abstract
    • The LIGO/Virgo collaboration published the catalogs GWTC-1, GWTC-2.1, and GWTC-3 containing candidate gravitational-wave (GW) events detected during its runs O1, O2, and O3. These GW events can be possible sites of neutrino emission. In this paper, we present a search for neutrino counterparts of 90 GW candidates using IceCube DeepCore, the low-energy infill array of the IceCube Neutrino Observatory. The search is conducted using an unbinned maximum likelihood method, within a time window of 1000 s, and uses the spatial and timing information from the GW events. The neutrinos used for the search have energies ranging from a few GeV to several tens of TeV. We do not find any significant emission of neutrinos, and place upper limits on the flux and the isotropic-equivalent energy emitted in low-energy neutrinos. We also conduct a binomial test to search for source populations potentially contributing to neutrino emission. We report a nondetection of a significant neutrino-source population with this test.
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7.
  • Abbasi, R., et al. (author)
  • A Search for Time-dependent Astrophysical Neutrino Emission with IceCube Data from 2012 to 2017
  • 2021
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 911:1
  • Journal article (peer-reviewed)abstract
    • High-energy neutrinos are unique messengers of the high-energy universe, tracing the processes of cosmic ray acceleration. This paper presents analyses focusing on time-dependent neutrino point-source searches. A scan of the whole sky, making no prior assumption about source candidates, is performed, looking for a space and time clustering of high-energy neutrinos in data collected by the IceCube Neutrino Observatory between 2012 and 2017. No statistically significant evidence for a time-dependent neutrino signal is found with this search during this period, as all results are consistent with the background expectation. Within this study period, the blazar 3C 279, showed strong variability, inducing a very prominent gamma-ray flare observed in 2015 June. This event motivated a dedicated study of the blazar, which consists of searching for a time-dependent neutrino signal correlated with the gamma-ray emission. No evidence for a time-dependent signal is found. Hence, an upper limit on the neutrino fluence is derived, allowing us to constrain a hadronic emission model.
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8.
  • Abbasi, R., et al. (author)
  • All-flavor constraints on nonstandard neutrino interactions and generalized matter potential with three years of IceCube DeepCore data
  • 2021
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 104:7
  • Journal article (peer-reviewed)abstract
    • We report constraints on nonstandard neutrino interactions (NSI) from the observation of atmospheric neutrinos with IceCube, limiting all individual coupling strengths from a single dataset. Furthermore, IceCube is the first experiment to constrain flavor-violating and nonuniversal couplings simultaneously. Hypothetical NSI are generically expected to arise due to the exchange of a new heavy mediator particle. Neutrinos propagating in matter scatter off fermions in the forward direction with negligible momentum transfer. Hence the study of the matter effect on neutrinos propagating in the Earth is sensitive to NSI independently of the energy scale of new physics. We present constraints on NSI obtained with an all-flavor event sample of atmospheric neutrinos based on three years of IceCube DeepCore data. The analysis uses neutrinos arriving from all directions, with reconstructed energies between 5.6 GeV and 100 GeV. We report constraints on the individual NSI coupling strengths considered singly, allowing for complex phases in the case of flavor-violating couplings. This demonstrates that IceCube is sensitive to the full NSI flavor structure at a level competitive with limits from the global analysis of all other experiments. In addition, we investigate a generalized matter potential, whose overall scale and flavor structure are also constrained.
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9.
  • Abbasi, R., et al. (author)
  • Constraints on Populations of Neutrino Sources from Searches in the Directions of IceCube Neutrino Alerts
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 951:1
  • Journal article (peer-reviewed)abstract
    • Beginning in 2016, the IceCube Neutrino Observatory has sent out alerts in real time containing the information of high-energy (E & GSIM; 100 TeV) neutrino candidate events with moderate to high (& GSIM;30%) probability of astrophysical origin. In this work, we use a recent catalog of such alert events, which, in addition to events announced in real time, includes events that were identified retroactively and covers the time period of 2011-2020. We also search for additional, lower-energy neutrinos from the arrival directions of these IceCube alerts. We show how performing such an analysis can constrain the contribution of rare populations of cosmic neutrino sources to the diffuse astrophysical neutrino flux. After searching for neutrino emission coincident with these alert events on various timescales, we find no significant evidence of either minute-scale or day-scale transient neutrino emission or of steady neutrino emission in the direction of these alert events. This study also shows how numerous a population of neutrino sources has to be to account for the complete astrophysical neutrino flux. Assuming that sources have the same luminosity, an E (-2.5) neutrino spectrum, and number densities that follow star formation rates, the population of sources has to be more numerous than 7 x 10(-9) Mpc(-3). This number changes to 3 x 10(-7) Mpc(-3) if number densities instead have no cosmic evolution.
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10.
  • Abbasi, R., et al. (author)
  • D-Egg : a dual PMT optical module for IceCube
  • 2023
  • In: Journal of Instrumentation. - : Institute of Physics Publishing (IOPP). - 1748-0221. ; 18:4
  • Journal article (peer-reviewed)abstract
    • The D-Egg, an acronym for "Dual optical sensors in an Ellipsoid Glass for Gen2," is one of the optical modules designed for future extensions of the IceCube experiment at the South Pole. The D-Egg has an elongated-sphere shape to maximize the photon-sensitive effective area while maintaining a narrow diameter to reduce the cost and the time needed for drilling of the deployment holes in the glacial ice for the optical modules at depths up to 2700 m. The D-Egg design is utilized for the IceCube Upgrade, the next stage of the IceCube project also known as IceCube-Gen2 Phase 1, where nearly half of the optical sensors to be deployed are D-Eggs. With two 8-inch high-quantum efficiency photomultiplier tubes (PMTs) per module, D-Eggs offer an increased effective area while retaining the successful design of the IceCube digital optical module (DOM). The convolution of the wavelength-dependent effective area and the Cherenkov emission spectrum provides an effective photodetection sensitivity that is 2.8 times larger than that of IceCube DOMs. The signal of each of the two PMTs is digitized using ultra-low-power 14-bit analog-to-digital converters with a sampling frequency of 240 MSPS, enabling a flexible event triggering, as well as seamless and lossless event recording of single-photon signals to multi-photons exceeding 200 photoelectrons within 10 ns. Mass production of D-Eggs has been completed, with 277 out of the 310 D-Eggs produced to be used in the IceCube Upgrade. In this paper, we report the design of the D-Eggs, as well as the sensitivity and the single to multi-photon detection performance of mass-produced D-Eggs measured in a laboratory using the built-in data acquisition system in each D-Egg optical sensor module.
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11.
  • Abbasi, R., et al. (author)
  • Density of GeV muons in air showers measured with IceTop
  • 2022
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 106:3
  • Journal article (peer-reviewed)abstract
    • We present a measurement of the density of GeV muons in near-vertical air showers using three years of data recorded by the IceTop array at the South Pole. Depending on the shower size, the muon densities have been measured at lateral distances between 200 and 1000 m. From these lateral distributions, we derive the muon densities as functions of energy at reference distances of 600 and 800 m for primary energies between 2.5 and 40 PeV and between 9 and 120 PeV, respectively. The muon densities are determined using, as a baseline, the hadronic interaction model Sibyll 2.1 together with various composition models. The measurements are consistent with the predicted muon densities within these baseline interaction and composition models. The measured muon densities have also been compared to simulations using the postLHC models EPOS-LHC and QGSJet-II.04. The result of this comparison is that the post-LHC models together with any given composition model yield higher muon densities than observed. This is in contrast to the observations above 1 EeV where all model simulations yield for any mass composition lower muon densities than the measured ones. The post-LHC models in general feature higher muon densities so that the agreement with experimental data at the highest energies is improved but the muon densities are not correct in the energy range between 2.5 and about 100 PeV.
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12.
  • Abbasi, R., et al. (author)
  • Evidence for neutrino emission from the nearby active galaxy NGC 1068
  • 2022
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 378:6619, s. 538-
  • Journal article (peer-reviewed)abstract
    • A supermassive black hole, obscured by cosmic dust, powers the nearby active galaxy NGC 1068. Neutrinos, which rarely interact with matter, could provide information on the galaxy's active core. We searched for neutrino emission from astrophysical objects using data recorded with the IceCube neutrino detector between 2011 and 2020. The positions of 110 known gamma-ray sources were individually searched for neutrino detections above atmospheric and cosmic backgrounds. We found that NGC 1068 has an excess of 79(-20)(+22) neutrinos at tera-electron volt energies, with a global significance of 4.2 sigma, which we interpret as associated with the active galaxy. The flux of high-energy neutrinos that we measured from NGC 1068 is more than an order of magnitude higher than the upper limit on emissions of tera-electron volt gamma rays from this source.
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13.
  • Abbasi, R., et al. (author)
  • Framework and tools for the simulation and analysis of the radio emission from air showers at IceCube
  • 2022
  • In: Journal of Instrumentation. - : IOP Publishing Ltd. - 1748-0221. ; 17:6
  • Journal article (peer-reviewed)abstract
    • The Surface Enhancement of the IceTop air-shower array will include the addition of radio antennas and scintillator panels, co-located with the existing ice-Cherenkov tanks and covering an area of about 1 km(2). Together, these will increase the sensitivity of the IceCube Neutrino Observatory to the electromagnetic and muonic components of cosmic-ray-induced air showers at the South Pole. The inclusion of the radio technique necessitates an expanded set of simulation and analysis tools to explore the radio-frequency emission from air showers in the 70 MHz to 350 MHz band. In this paper we describe the software modules that have been developed to work with time-and frequency-domain information within IceCube's existing software framework, IceTray, which is used by the entire IceCube collaboration. The software includes a method by which air-shower simulation, generated using CoREAS, can be reused via waveform interpolation, thus overcoming a significant computational hurdle in the field.
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14.
  • Abbasi, R., et al. (author)
  • Graph Neural Networks for low-energy event classification & reconstruction in IceCube
  • 2022
  • In: Journal of Instrumentation. - : IOP Publishing Ltd. - 1748-0221. ; 17:11
  • Journal article (peer-reviewed)abstract
    • IceCube, a cubic-kilometer array of optical sensors built to detect atmospheric and astrophysical neutrinos between 1 GeV and 1 PeV, is deployed 1.45 km to 2.45 km below the surface of the ice sheet at the South Pole. The classification and reconstruction of events from the in-ice detectors play a central role in the analysis of data from IceCube. Reconstructing and classifying events is a challenge due to the irregular detector geometry, inhomogeneous scattering and absorption of light in the ice and, below 100 GeV, the relatively low number of signal photons produced per event. To address this challenge, it is possible to represent IceCube events as point cloud graphs and use a Graph Neural Network (GNN) as the classification and reconstruction method. The GNN is capable of distinguishing neutrino events from cosmic-ray backgrounds, classifying different neutrino event types, and reconstructing the deposited energy, direction and interaction vertex. Based on simulation, we provide a comparison in the 1 GeV-100 GeV energy range to the current state-of-the-art maximum likelihood techniques used in current IceCube analyses, including the effects of known systematic uncertainties. For neutrino event classification, the GNN increases the signal efficiency by 18% at a fixed background rate, compared to current IceCube methods. Alternatively, the GNN offers a reduction of the background (i.e. false positive) rate by over a factor 8 (to below half a percent) at a fixed signal efficiency. For the reconstruction of energy, direction, and interaction vertex, the resolution improves by an average of 13%-20% compared to current maximum likelihood techniques in the energy range of 1 GeV-30 GeV. The GNN, when run on a GPU, is capable of processing IceCube events at a rate nearly double of the median IceCube trigger rate of 2.7 kHz, which opens the possibility of using low energy neutrinos in online searches for transient events.
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15.
  • Abbasi, R., et al. (author)
  • IceCat-1: The IceCube Event Catalog of Alert Tracks
  • 2023
  • In: Astrophysical Journal, Supplement Series. - : IOP Publishing Ltd. - 1538-4365 .- 0067-0049. ; 269:1
  • Journal article (peer-reviewed)abstract
    • We present a catalog of likely astrophysical neutrino track-like events from the IceCube Neutrino Observatory. IceCube began reporting likely astrophysical neutrinos in 2016, and this system was updated in 2019. The catalog presented here includes events that were reported in real time since 2019, as well as events identified in archival data samples starting from 2011. We report 275 neutrino events from two selection channels as the first entries in the catalog, the IceCube Event Catalog of Alert Tracks, which will see ongoing extensions with additional alerts. The Gold and Bronze alert channels respectively provide neutrino candidates with a 50% and 30% probability of being astrophysical, on average assuming an astrophysical neutrino power-law energy spectral index of 2.19. For each neutrino alert, we provide the reconstructed energy, direction, false-alarm rate, probability of being astrophysical in origin, and likelihood contours describing the spatial uncertainty in the alert's reconstructed location. We also investigate a directional correlation of these neutrino events with gamma-ray and X-ray catalogs, including 4FGL, 3HWC, TeVCat, and Swift-BAT.
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16.
  • Abbasi, R., et al. (author)
  • Improved Characterization of the Astrophysical Muon-neutrino Flux with 9.5 Years of IceCube Data
  • 2022
  • In: Astrophysical Journal. - : IOP Publishing Ltd. - 0004-637X .- 1538-4357. ; 928:1
  • Journal article (peer-reviewed)abstract
    • We present a measurement of the high-energy astrophysical muon-neutrino flux with the IceCube Neutrino Observatory. The measurement uses a high-purity selection of 650k neutrino-induced muon tracks from the northern celestial hemisphere, corresponding to 9.5 yr of experimental data. With respect to previous publications, the measurement is improved by the increased size of the event sample and the extended model testing beyond simple power-law hypotheses. An updated treatment of systematic uncertainties and atmospheric background fluxes has been implemented based on recent models. The best-fit single power-law parameterization for the astrophysical energy spectrum results in a normalization of phi(nu mu+(nu) over bar mu)(@ 00TeV) = 1.441(-0.26)(+0.25 )x 10(-18) GeV(-1)cm(-2) s(-1 )sr(-1) and a spectral index gamma(SPL) = 2.37(-0.09)(+0.09), constrained in the energy range from 15 TeV to 5 PeV. The model tests include a single power law with a spectral cutoff at high energies, a log-parabola model, several source-class-specific flux predictions from the literature, and a model-independent spectral unfolding. The data are consistent with a single power-law hypothesis, however, spectra with softening above one PeV are statistically more favorable at a two-sigma level.
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17.
  • Abbasi, R., et al. (author)
  • LeptonInjector and LeptonWeighter : A neutrino event generator and weighter for neutrino observatories
  • 2021
  • In: Computer Physics Communications. - : Elsevier. - 0010-4655 .- 1879-2944. ; 266
  • Journal article (peer-reviewed)abstract
    • We present a high-energy neutrino event generator, called LeptonInjector, alongside an event weighter, called LeptonWeighter. Both are designed for large-volume Cherenkov neutrino telescopes such as IceCube. The neutrino event generator allows for quick and flexible simulation of neutrino events within and around the detector volume, and implements the leading Standard Model neutrino interaction processes relevant for neutrino observatories: neutrino-nucleon deep-inelastic scattering and neutrino-electron annihilation. In this paper, we discuss the event generation algorithm, the weighting algorithm, and the main functions of the publicly available code, with examples.
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18.
  • Abbasi, R., et al. (author)
  • Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory
  • 2023
  • In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 946:1
  • Journal article (peer-reviewed)abstract
    • Gamma-ray bursts (GRBs) have long been considered a possible source of high-energy neutrinos. While no correlations have yet been detected between high-energy neutrinos and GRBs, the recent observation of GRB 221009A-the brightest GRB observed by Fermi-GBM to date and the first one to be observed above an energy of 10 TeV-provides a unique opportunity to test for hadronic emission. In this paper, we leverage the wide energy range of the IceCube Neutrino Observatory to search for neutrinos from GRB 221009A. We find no significant deviation from background expectation across event samples ranging from MeV to PeV energies, placing stringent upper limits on the neutrino emission from this source.
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19.
  • Abbasi, R., et al. (author)
  • Low energy event reconstruction in IceCube DeepCore
  • 2022
  • In: European Physical Journal C. - : Springer Nature. - 1434-6044 .- 1434-6052. ; 82:9
  • Journal article (peer-reviewed)abstract
    • The reconstruction of event-level information, such as the direction or energy of a neutrino interacting in IceCube DeepCore, is a crucial ingredient to many physics analyses. Algorithms to extract this high level information from the detector's raw data have been successfully developed and used for high energy events. In this work, we address unique challenges associated with the reconstruction of lower energy events in the range of a few to hundreds of GeV and present two separate, state-of-the-art algorithms. One algorithm focuses on the fast directional reconstruction of events based on unscattered light. The second algorithm is a likelihood-based multipurpose reconstruction offering superior resolutions, at the expense of larger computational cost.
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20.
  • Abbasi, R., et al. (author)
  • Observation of seasonal variations of the flux of high-energy atmospheric neutrinos with IceCube
  • 2023
  • In: European Physical Journal C. - : Springer. - 1434-6044 .- 1434-6052. ; 83:9
  • Journal article (peer-reviewed)abstract
    • Atmospheric muon neutrinos are produced by meson decays in cosmic-ray-induced air showers. The flux depends on meteorological quantities such as the air temperature, which affects the density of air. Competition between decay and re-interaction of those mesons in the first particle production generations gives rise to a higher neutrino flux when the air density in the stratosphere is lower, corresponding to a higher temperature. A measurement of a temperature dependence of the atmospheric vμ, flux provides a novel method for constraining hadronic interaction models of air showers. It is particularly sensitive to the production of kaons. Studying this temperature dependence for the first time requires a large sample of high-energy neutrinos as well as a detailed understanding of atmospheric properties. We report the significant (> 10 σ) observation of a correlation between the rate of more than 260,000 neutrinos, detected by IceCube between 2012 and 2018, and atmospheric tem-peratures of the stratosphere, measured by the Atmospheric Infrared Sounder (AIRS) instrument aboard NASA's AQUA satellite. For the observed 10% seasonal change of effective atmospheric temperature we measure a 3.5(3)% change in the muon neutrino flux. This observed correlation deviates by about 2-3 standard deviations from the expected correla-tion of 4.3% as obtained from theoretical predictions under the assumption of various hadronic interaction models.
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21.
  • Abbasi, R., et al. (author)
  • Observation of seasonal variations of the flux of high-energy atmospheric neutrinos with IceCube
  • 2023
  • In: European Physical Journal C. - : Springer. - 1434-6044 .- 1434-6052. ; 83:9
  • Journal article (peer-reviewed)abstract
    • Atmospheric muon neutrinos are produced by meson decays in cosmic-ray-induced air showers. The flux depends on meteorological quantities such as the air temperature, which affects the density of air. Competition between decay and re-interaction of those mesons in the first particle production generations gives rise to a higher neutrino flux when the air density in the stratosphere is lower, corresponding to a higher temperature. A measurement of a temperature dependence of the atmospheric νμ flux provides a novel method for constraining hadronic interaction models of air showers. It is particularly sensitive to the production of kaons. Studying this temperature dependence for the first time requires a large sample of high-energy neutrinos as well as a detailed understanding of atmospheric properties. We report the significant (>10σ) observation of a correlation between the rate of more than 260,000 neutrinos, detected by IceCube between 2012 and 2018, and atmospheric temperatures of the stratosphere, measured by the Atmospheric Infrared Sounder (AIRS) instrument aboard NASA’s AQUA satellite. For the observed 10 % seasonal change of effective atmospheric temperature we measure a 3.5(3) % change in the muon neutrino flux. This observed correlation deviates by about 2-3 standard deviations from the expected correlation of 4.3 % as obtained from theoretical predictions under the assumption of various hadronic interaction models.
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22.
  • Abbasi, R., et al. (author)
  • Search for 10-1000 GeV Neutrinos from Gamma-Ray Bursts with IceCube
  • 2024
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 964:2
  • Journal article (peer-reviewed)abstract
    • We present the results of a search for 10-1000 GeV neutrinos from 2268 gamma-ray bursts (GRBs) over 8 yr of IceCube-DeepCore data. This work probes burst physics below the photosphere where electromagnetic radiation cannot escape. Neutrinos of tens of giga electronvolts are predicted in sub-photospheric collision of free-streaming neutrons with bulk-jet protons. In a first analysis, we searched for the most significant neutrino-GRB coincidence using six overlapping time windows centered on the prompt phase of each GRB. In a second analysis, we conducted a search for a group of GRBs, each individually too weak to be detectable, but potentially significant when combined. No evidence of neutrino emission is found for either analysis. The most significant neutrino coincidence is for Fermi-GBM GRB bn 140807500, with a p-value of 0.097 corrected for all trials. The binomial test used to search for a group of GRBs had a p-value of 0.65 after all trial corrections. The binomial test found a group consisting only of GRB bn 140807500 and no additional GRBs. The neutrino limits of this work complement those obtained by IceCube at tera electronvolt to peta electronvolt energies. We compare our findings for the large set of GRBs as well as GRB 221009A to the sub-photospheric neutron-proton collision model and find that GRB 221009A provides the most constraining limit on baryon loading. For a jet Lorentz factor of 300 (800), the baryon loading on GRB 221009A is lower than 3.85 (2.13) at a 90% confidence level.
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23.
  • Abbasi, R., et al. (author)
  • Search for 10-1000 GeV Neutrinos from Gamma-Ray Bursts with IceCube
  • 2024
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 1538-4357 .- 0004-637X. ; 964:2
  • Journal article (peer-reviewed)abstract
    • We present the results of a search for 10-1000 GeV neutrinos from 2268 gamma-ray bursts (GRBs) over 8 yr of IceCube-DeepCore data. This work probes burst physics below the photosphere where electromagnetic radiation cannot escape. Neutrinos of tens of giga electronvolts are predicted in sub-photospheric collision of free-streaming neutrons with bulk-jet protons. In a first analysis, we searched for the most significant neutrino-GRB coincidence using six overlapping time windows centered on the prompt phase of each GRB. In a second analysis, we conducted a search for a group of GRBs, each individually too weak to be detectable, but potentially significant when combined. No evidence of neutrino emission is found for either analysis. The most significant neutrino coincidence is for Fermi-GBM GRB bn 140807500, with a p-value of 0.097 corrected for all trials. The binomial test used to search for a group of GRBs had a p-value of 0.65 after all trial corrections. The binomial test found a group consisting only of GRB bn 140807500 and no additional GRBs. The neutrino limits of this work complement those obtained by IceCube at tera electronvolt to peta electronvolt energies. We compare our findings for the large set of GRBs as well as GRB 221009A to the sub-photospheric neutron-proton collision model and find that GRB 221009A provides the most constraining limit on baryon loading. For a jet Lorentz factor of 300 (800), the baryon loading on GRB 221009A is lower than 3.85 (2.13) at a 90% confidence level.
  •  
24.
  • Abbasi, R., et al. (author)
  • Search for Astrophysical Neutrinos from 1FLE Blazars with IceCube
  • 2022
  • In: Astrophysical Journal. - : IOP Publishing Ltd. - 0004-637X .- 1538-4357. ; 938:1
  • Journal article (peer-reviewed)abstract
    • The origin of astrophysical neutrinos has yet to be determined. The IceCube Neutrino Observatory has observed astrophysical neutrinos but has not yet identified their sources. Blazars are promising source candidates, but previous searches for neutrino emission from populations of blazars detected in $\gtrsim$ GeV gamma-rays have not observed any significant neutrino excess. Recent findings in multi-messenger astronomy indicate that high-energy photons, co-produced with high-energy neutrinos, are likely to be absorbed and reemitted at lower energies. Thus, lower-energy photons may be better indicators of TeV-PeV neutrino production. This paper presents the first time-integrated stacking search for astrophysical neutrino emission from MeV-detected blazars in the first Fermi-LAT low energy catalog (1FLE) using ten years of IceCube muon-neutrino data. The results of this analysis are found to be consistent with a background-only hypothesis. Assuming an E$<^>{-2}$ neutrino spectrum and proportionality between the blazars' MeV gamma-ray fluxes and TeV-PeV neutrino flux, the upper limit on the 1FLE blazar energy-scaled neutrino flux is determined to be $1.64 \times 10<^>{-12}$ TeV cm$<^>{-2}$ s$<^>{-1}$ at 90% confidence level. This upper limit is approximately 1% of IceCube's diffuse muon-neutrino flux measurement.
  •  
25.
  • Abbasi, R., et al. (author)
  • Search for Correlations of High-energy Neutrinos Detected in IceCube with Radio-bright AGN and Gamma-Ray Emission from Blazars
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 954:1
  • Journal article (peer-reviewed)abstract
    • The IceCube Neutrino Observatory sends realtime neutrino alerts with a high probability of being astrophysical in origin. We present a new method to correlate these events and possible candidate sources using 2089 blazars from the Fermi-LAT 4LAC-DR2 catalog and with 3413 active galactic nuclei (AGNs) from the Radio Fundamental Catalog. No statistically significant neutrino emission was found in any of the catalog searches. The result suggests that a small fraction, <1%, of the studied AGNs emit neutrinos that pass the alert criteria, and is compatible with prior evidence for neutrino emission presented by IceCube and other authors from sources such as TXS 0506 + 056 and PKS 1502 + 106. We also present cross-checks to other analyses that claim a significant correlation using similar data samples.
  •  
26.
  • Abbasi, R., et al. (author)
  • Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 956:1
  • Journal article (peer-reviewed)abstract
    • The Galactic plane, harboring a diffuse neutrino flux, is a particularly interesting target in which to study potential cosmic-ray acceleration sites. Recent gamma-ray observations by HAWC and LHAASO have presented evidence for multiple Galactic sources that exhibit a spatially extended morphology and have energy spectra continuing beyond 100 TeV. A fraction of such emission could be produced by interactions of accelerated hadronic cosmic rays, resulting in an excess of high-energy neutrinos clustered near these regions. Using 10 years of IceCube data comprising track-like events that originate from charged-current muon neutrino interactions, we perform a dedicated search for extended neutrino sources in the Galaxy. We find no evidence for time-integrated neutrino emission from the potential extended sources studied in the Galactic plane. The most significant location, at 2.6 sigma post-trials, is a 1.degrees 7 sized region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We provide strong constraints on hadronic emission from several regions in the galaxy.
  •  
27.
  • Abbasi, R., et al. (author)
  • Search for Galactic Core-collapse Supernovae in a Decade of Data Taken with the IceCube Neutrino Observatory
  • 2024
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 1538-4357 .- 0004-637X. ; 961:1
  • Journal article (peer-reviewed)abstract
    • The IceCube Neutrino Observatory has been continuously taking data to search for O(0.5–10) s long neutrino bursts since 2007. Even if a Galactic core-collapse supernova is optically obscured or collapses to a black hole instead of exploding, it will be detectable via the O(10) MeV neutrino burst emitted during the collapse. We discuss a search for such events covering the time between 2008 April 17 and 2019 December 31. Considering the average data taking and analysis uptime of 91.7% after all selection cuts, this is equivalent to 10.735 yr of continuous data taking. In order to test the most conservative neutrino production scenario, the selection cuts were optimized for a model based on an 8.8 solar mass progenitor collapsing to an O–Ne–Mg core. Conservative assumptions on the effects of neutrino oscillations in the exploding star were made. The final selection cut was set to ensure that the probability to detect such a supernova within the Milky Way exceeds 99%. No such neutrino burst was found in the data after performing a blind analysis. Hence, a 90% C.L. upper limit on the rate of core-collapse supernovae out to distances of ≈25 kpc was determined to be 0.23 yr−1. For the more distant Magellanic Clouds, only high neutrino luminosity supernovae will be detectable by IceCube, unless external information on the burst time is available. We determined a model-independent limit by parameterizing the dependence on the neutrino luminosity and the energy spectrum.
  •  
28.
  • Abbasi, R., et al. (author)
  • Search for GeV neutrino emission during intense gamma-ray solar flares with the IceCube Neutrino Observatory
  • 2021
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 103:10
  • Journal article (peer-reviewed)abstract
    • Solar flares convert magnetic energy into thermal and nonthermal plasma energy, the latter implying particle acceleration of charged particles such as protons. Protons are injected out of the coronal acceleration region and can interact with dense plasma in the lower solar atmosphere, producing mesons that subsequently decay into gamma rays and neutrinos at O(MeV-GeV) energies. We present the results of the first search for GeV neutrinos emitted during solar flares carried out with the IceCube Neutrino Observatory. While the experiment was originally designed to detect neutrinos with energies between 10 GeV and a few PeV, a new approach allowing for a O(GeV) energy threshold will be presented. The resulting limits allow us to constrain some of the theoretical estimates of the expected neutrino flux.
  •  
29.
  • Abbasi, R., et al. (author)
  • Search for GeV-scale dark matter annihilation in the Sun with IceCube DeepCore
  • 2022
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 105:6
  • Journal article (peer-reviewed)abstract
    • The Sun provides an excellent target for studying spin-dependent dark matter-proton scattering due to its high matter density and abundant hydrogen content. Dark matter particles from the Galactic halo can elastically interact with Solar nuclei, resulting in their capture and thermalization in the Sun. The captured dark matter can annihilate into Standard Model particles including an observable flux of neutrinos. We present the results of a search for low-energy (<500 GeV) neutrinos correlated with the direction of the Sun using 7 years of IceCube data. This work utilizes, for the first time, new optimized cuts to extend IceCube's sensitivity to dark matter mass down to 5 GeV. We find no significant detection of neutrinos from the Sun. Our observations exclude capture by spin-dependent dark matter-proton scattering with cross section down to a few times 10(-41) cm(2), assuming there is equilibrium with annihilation into neutrinos/antineutrinos for dark matter masses between 5 GeV and 100 GeV. These are the strongest constraints at GeV energies for dark matter annihilation directly to neutrinos.
  •  
30.
  • Abbasi, R., et al. (author)
  • Search for High-energy Neutrino Emission from Galactic X-Ray Binaries with IceCube
  • 2022
  • In: Astrophysical Journal Letters. - : IOP Publishing Ltd. - 2041-8205 .- 2041-8213. ; 930:2
  • Journal article (peer-reviewed)abstract
    • We present the first comprehensive search for high-energy neutrino emission from high- and low-mass X-ray binaries conducted by IceCube. Galactic X-ray binaries are long-standing candidates for the source of Galactic hadronic cosmic rays and neutrinos. The compact object in these systems can be the site of cosmic-ray acceleration, and neutrinos can be produced by interactions of cosmic rays with radiation or gas, in the jet of a microquasar, in the stellar wind, or in the atmosphere of the companion star. We study X-ray binaries using 7.5 yr of IceCube data with three separate analyses. In the first, we search for periodic neutrino emission from 55 binaries in the Northern Sky with known orbital periods. In the second, the X-ray light curves of 102 binaries across the entire sky are used as templates to search for time-dependent neutrino emission. Finally, we search for time-integrated emission of neutrinos for a list of 4 notable binaries identified as microquasars. In the absence of a significant excess, we place upper limits on the neutrino flux for each hypothesis and compare our results with theoretical predictions for several binaries. In addition, we evaluate the sensitivity of the next generation neutrino telescope at the South Pole, IceCube-Gen2, and demonstrate its power to identify potential neutrino emission from these binary sources in the Galaxy.
  •  
31.
  • Abbasi, R., et al. (author)
  • Search for High-energy Neutrinos from Ultraluminous Infrared Galaxies with IceCube
  • 2022
  • In: Astrophysical Journal. - : IOP Publishing Ltd. - 0004-637X .- 1538-4357. ; 926:1
  • Journal article (peer-reviewed)abstract
    • Ultraluminous infrared galaxies (ULIRGs) have infrared luminosities L-IR >= 10(12) L-circle dot, making them the most luminous objects in the infrared sky. These dusty objects are generally powered by starbursts with star formation rates that exceed 100M(circle dot) yr(-1), possibly combined with a contribution from an active galactic nucleus. Such environments make ULIRGs plausible sources of astrophysical high-energy neutrinos, which can be observed by the IceCube Neutrino Observatory at the South Pole. We present a stacking search for high-energy neutrinos from a representative sample of 75 ULIRGs with redshift z <= 0.13 using 7.5 yr of IceCube data. The results are consistent with a background-only observation, yielding upper limits on the neutrino flux from these 75 ULIRGs. For an unbroken E-2.5 power-law spectrum, we report an upper limit on the stacked flux Phi(90%)(nu mu+(nu) over bar mu) = 3.24 x 10(-14) TeV-1 cm(-2) S-1 (E/10 TeV)(-2.5) at 90% confidence level. In addition, we constrain the contribution of the ULIRG source population to the observed diffuse astrophysical neutrino flux as well as model predictions.
  •  
32.
  • Abbasi, R., et al. (author)
  • Search for Multi-flare Neutrino Emissions in 10 yr of IceCube Data from a Catalog of Sources
  • 2021
  • In: Astrophysical Journal Letters. - : Institute of Physics Publishing (IOPP). - 2041-8205 .- 2041-8213. ; 920:2
  • Journal article (peer-reviewed)abstract
    • A recent time-integrated analysis of a catalog of 110 candidate neutrino sources revealed a cumulative neutrino excess in the data collected by IceCube between 2008 April 6 and 2018 July 10. This excess, inconsistent with the background hypothesis in the Northern Hemisphere at the 3.3 sigma level, is associated with four sources: NGC 1068, TXS 0506+056, PKS 1424+240, and GB6 J1542+6129. This Letter presents two time-dependent neutrino emission searches on the same data sample and catalog: a point-source search that looks for the most significant time-dependent source of the catalog by combining space, energy, and time information of the events, and a population test based on binomial statistics that looks for a cumulative time-dependent neutrino excess from a subset of sources. Compared to previous time-dependent searches, these analyses enable a feature to possibly find multiple flares from a single direction with an unbinned maximum-likelihood method. M87 is found to be the most significant time-dependent source of this catalog at the level of 1.7 sigma post-trial, and TXS 0506+056 is the only source for which two flares are reconstructed. The binomial test reports a cumulative time-dependent neutrino excess in the Northern Hemisphere at the level of 3.0 sigma associated with four sources: M87, TXS 0506+056, GB6 J1542+6129, and NGC 1068.
  •  
33.
  • Abbasi, R., et al. (author)
  • Search for neutrino emission from cores of active galactic nuclei
  • 2022
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 106:2
  • Journal article (peer-reviewed)abstract
    • The sources of the majority of the high-energy astrophysical neutrinos observed with the IceCube neutrino telescope at the South Pole are unknown. So far, only a flaring gamma-ray blazar was compellingly associated with the emission of high-energy neutrinos. However, several studies suggest that the neutrino emission from the gamma-ray blazar population only accounts for a small fraction of the total astrophysical neutrino flux. In this work we probe the production of high-energy neutrinos in the cores of active galactic nuclei (AGN), induced by accelerated cosmic rays in the accretion disk region. We present a likelihood analysis based on eight years of IceCube data, searching for a cumulative neutrino signal from three AGN samples created for this work. The neutrino emission is assumed to be proportional to the accretion disk luminosity estimated from the soft x-ray flux. Next to the observed soft x-ray flux, the objects for the three samples have been selected based on their radio emission and infrared color properties. For the largest sample in this search, an excess of high-energy neutrino events with respect to an isotropic background of atmospheric and astrophysical neutrinos is found, corresponding to a post-trial significance of 2.60 sigma. If interpreted as a genuine signal with the assumptions of a proportionality of x-ray and neutrino fluxes and a model for the subthreshold flux distribution, then this observation implies that at 100 TeV, 27%-100% of the observed neutrinos arise from particle acceleration in the core of AGN at 1 sigma confidence interval.
  •  
34.
  • Abbasi, R., et al. (author)
  • Search for neutrino lines from dark matter annihilation and decay with IceCube
  • 2023
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 108:10
  • Journal article (peer-reviewed)abstract
    • Dark matter particles in the Galactic Center and halo can annihilate or decay into a pair of neutrinos producing a monochromatic flux of neutrinos. The spectral feature of this signal is unique and it is not expected from any astrophysical production mechanism. Its observation would constitute a dark matter smoking gun signal. We performed the first dedicated search with a neutrino telescope for such signal, by looking at both the angular and energy information of the neutrino events. To this end, a total of five years of IceCube's DeepCore data has been used to test dark matter masses ranging from 10 GeV to 40 TeV. No significant neutrino excess was found and upper limits on the annihilation cross section, as well as lower limits on the dark matter lifetime, were set. The limits reached are of the order of 10-24 cm3/s for an annihilation and up to 1027 s for decaying dark matter. Using the same data sample we also derive limits for dark matter annihilation or decay into a pair of Standard Model charged particles.
  •  
35.
  • Abbasi, R., et al. (author)
  • Search for Relativistic Magnetic Monopoles with Eight Years of IceCube Data
  • 2022
  • In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 128:5
  • Journal article (peer-reviewed)abstract
    • We present an all-sky 90% confidence level upper limit on the cosmic flux of relativistic magnetic monopoles using 2886 days of IceCube data. The analysis was optimized for monopole speeds between 0.750c and 0.995c, without any explicit restriction on the monopole mass. We constrain the flux of relativistic cosmic magnetic monopoles to a level below 2.0 x 10(-19) cm(-2) s(-1) sr(-1) over the majority of the targeted speed range. This result constitutes the most strict upper limit to date for magnetic monopoles with beta > 0.8 and up to beta similar to 0.995 and fills the gap between existing limits on the cosmic flux of nonrelativistic and ultrarelativistic magnetic monopoles.
  •  
36.
  • Abbasi, R., et al. (author)
  • Search for sub-TeV Neutrino Emission from Novae with IceCube-DeepCore
  • 2023
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 953:2
  • Journal article (peer-reviewed)abstract
    • The understanding of novae, the thermonuclear eruptions on the surfaces of white dwarf stars in binaries, has recently undergone a major paradigm shift. Though the bolometric luminosity of novae was long thought to arise directly from photons supplied by the thermonuclear runaway, recent gigaelectronvolt (GeV) gamma-ray observations have supported the notion that a significant portion of the luminosity could come from radiative shocks. More recently, observations of novae have lent evidence that these shocks are acceleration sites for hadrons for at least some types of novae. In this scenario, a flux of neutrinos may accompany the observed gamma rays. As the gamma rays from most novae have only been observed up to a few GeV, novae have previously not been considered as targets for neutrino telescopes, which are most sensitive at and above teraelectronvolt (TeV) energies. Here, we present the first search for neutrinos from novae with energies between a few GeV and 10 TeV using IceCube-DeepCore, a densely instrumented region of the IceCube Neutrino Observatory with a reduced energy threshold. We search both for a correlation between gamma-ray and neutrino emission as well as between optical and neutrino emission from novae. We find no evidence for neutrino emission from the novae considered in this analysis and set upper limits for all gamma-ray detected novae.
  •  
37.
  • Abbasi, R., et al. (author)
  • Search for unstable sterile neutrinos with the icecube neutrino observatory
  • 2022
  • In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 129:15
  • Journal article (peer-reviewed)abstract
    • We present a search for an unstable sterile neutrino by looking for a resonant signal in eight years of atmospheric νμ data collected from 2011 to 2019 at the IceCube Neutrino Observatory. Both the (stable) three-neutrino and the 3+1 sterile neutrino models are disfavored relative to the unstable sterile neutrino model, though with p values of 2.8% and 0.81%, respectively, we do not observe evidence for 3+1 neutrinos with neutrino decay. The best-fit parameters for the sterile neutrino with decay model from this study are Δm241=6.7+3.9−2.5  eV2, sin22θ24=0.33+0.20−0.17, and g2=2.5π±1.5π, where g is the decay-mediating coupling. The preferred regions of the 3+1+decay model from short-baseline oscillation searches are excluded at 90% C.L.
  •  
38.
  • Abbasi, R., et al. (author)
  • Searches for connections between dark matter and high-energy neutrinos with IceCube
  • 2023
  • In: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics (IOP). - 1475-7516. ; :10, s. 003-
  • Journal article (peer-reviewed)abstract
    • In this work, we present the results of searches for signatures of dark matter decay or annihilation into Standard Model particles, and secret neutrino interactions with dark matter. Neutrinos could be produced in the decay or annihilation of galactic or extragalactic dark matter. Additionally, if an interaction between dark matter and neutrinos exists then dark matter will interact with extragalactic neutrinos. In particular galactic dark matter will induce an anisotropy in the neutrino sky if this interaction is present. We use seven and a half years of the High-Energy Starting Event (HESE) sample data, which measures neutrinos in the energy range of approximately 60 TeV to 10 PeV, to study these phenomena. This all-sky event selection is dominated by extragalactic neutrinos. For dark matter of similar to 1 PeV in mass, we constrain the velocity-averaged annihilation cross section to be smaller than 10(-23) cm(3)/s for the exclusive mu(+) mu(-) channel and 10(-22) cm(3)/s for the b (b) over bar channel. For the same mass, we constrain the lifetime of dark matter to be larger than 10(28) s for all channels studied, except for decaying exclusively to b (b) over bar where it is bounded to be larger than 10(27) s. Finally, we also search for evidence of astrophysical neutrinos scattering on galactic dark matter in two scenarios. For fermionic dark matter with a vector mediator, we constrain the dimensionless coupling associated with this interaction to be less than 0.1 for dark matter mass of 0.1 GeV and a mediator mass of 10(-4) GeV. In the case of scalar dark matter with a fermionic mediator, we constrain the coupling to be less than 0.1 for dark matter and mediator masses below 1MeV.
  •  
39.
  • Abbasi, R., et al. (author)
  • Searches for Neutrinos from Gamma-Ray Bursts Using the IceCube Neutrino Observatory
  • 2022
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 939:2
  • Journal article (peer-reviewed)abstract
    • Gamma-ray bursts (GRBs) are considered as promising sources of ultra-high-energy cosmic rays (UHECRs) due to their large power output. Observing a neutrino flux from GRBs would offer evidence that GRBs are hadronic accelerators of UHECRs. Previous IceCube analyses, which primarily focused on neutrinos arriving in temporal coincidence with the prompt gamma-rays, found no significant neutrino excess. The four analyses presented in this paper extend the region of interest to 14 days before and after the prompt phase, including generic extended time windows and targeted precursor searches. GRBs were selected between 2011 May and 2018 October to align with the data set of candidate muon-neutrino events observed by IceCube. No evidence of correlation between neutrino events and GRBs was found in these analyses. Limits are set to constrain the contribution of the cosmic GRB population to the diffuse astrophysical neutrino flux observed by IceCube. Prompt neutrino emission from GRBs is limited to less than or similar to 1% of the observed diffuse neutrino flux, and emission on timescales up to 10(4) s is constrained to 24% of the total diffuse flux.
  •  
40.
  • Abbasi, R., et al. (author)
  • Searching for High-energy Neutrino Emission from Galaxy Clusters with IceCube
  • 2022
  • In: Astrophysical Journal Letters. - : IOP Publishing Ltd. - 2041-8205 .- 2041-8213. ; 938:2
  • Journal article (peer-reviewed)abstract
    • Galaxy clusters have the potential to accelerate cosmic rays (CRs) to ultrahigh energies via accretion shocks or embedded CR acceleration sites. The CRs with energies below the Hillas condition will be confined within the cluster and eventually interact with the intracluster medium gas to produce secondary neutrinos and gamma rays. Using 9.5 yr of muon neutrino track events from the IceCube Neutrino Observatory, we report the results of a stacking analysis of 1094 galaxy clusters with masses greater than or similar to 10(14) M (circle dot) and redshifts between 0.01 and similar to 1 detected by the Planck mission via the Sunyaev-Zel'dovich effect. We find no evidence for significant neutrino emission and report upper limits on the cumulative unresolved neutrino flux from massive galaxy clusters after accounting for the completeness of the catalog up to a redshift of 2, assuming three different weighting scenarios for the stacking and three different power-law spectra. Weighting the sources according to mass and distance, we set upper limits at a 90% confidence level that constrain the flux of neutrinos from massive galaxy clusters (greater than or similar to 10(14) M (circle dot)) to be no more than 4.6% of the diffuse IceCube observations at 100 TeV, assuming an unbroken E (-2.5) power-law spectrum.
  •  
41.
  • Abbasi, R., et al. (author)
  • Strong Constraints on Neutrino Nonstandard Interactions from TeV-Scale νμ Disappearance at IceCube
  • 2022
  • In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 129:1
  • Journal article (peer-reviewed)abstract
    • We report a search for nonstandard neutrino interactions (NSI) using eight years of TeV-scale atmospheric muon neutrino data from the IceCube Neutrino Observatory. By reconstructing incident energies and zenith angles for atmospheric neutrino events, this analysis presents unified confidence intervals for the NSI parameter epsilon(mu tau). The best-fit value is consistent with no NSI at a p value of 25.2%. With a 90% confidence interval of -0.0041 <= epsilon(mu tau) <= 0.0031 along the real axis and similar strength in the complex plane, this result is the strongest constraint on any NSI parameter from any oscillation channel to date.
  •  
42.
  • Albert, A., et al. (author)
  • Search for Spatial Correlations of Neutrinos with Ultra-high-energy Cosmic Rays
  • 2022
  • In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 934:2
  • Journal article (peer-reviewed)abstract
    • For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data are provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above similar to 50 EeV are provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrino clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses have found a significant excess, and previously reported overfluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs.
  •  
43.
  • Manning, Alisa, et al. (author)
  • A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
  • 2017
  • In: Diabetes. - : AMER DIABETES ASSOC. - 0012-1797 .- 1939-327X. ; 66:7, s. 2019-2032
  • Journal article (peer-reviewed)abstract
    • To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting plasma insulin (FI), a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in FI levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-h insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio 1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.
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44.
  •  
45.
  • Wang, Haidong, et al. (author)
  • Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015 : a systematic analysis for the Global Burden of Disease Study 2015
  • 2016
  • In: The Lancet. - 0140-6736 .- 1474-547X. ; 388:10053, s. 1459-1544
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14 294 geography-year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER).FINDINGS: Globally, life expectancy from birth increased from 61·7 years (95% uncertainty interval 61·4-61·9) in 1980 to 71·8 years (71·5-72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7-17·4), to 62·6 years (56·5-70·2). Total deaths increased by 4·1% (2·6-5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0% (15·8-18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1% (12·6-16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1% (11·9-14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1%, 39·1-44·6), malaria (43·1%, 34·7-51·8), neonatal preterm birth complications (29·8%, 24·8-34·9), and maternal disorders (29·1%, 19·3-37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393 000 deaths, 228 000-532 000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost [YLLs]) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death.INTERPRETATION: At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems.
  •  
46.
  • Wetter, Oliver, et al. (author)
  • The year-long unprecedented European heat and drought of 1540-a worst case
  • 2014
  • In: Climatic Change. - : Springer Science and Business Media LLC. - 0165-0009 .- 1573-1480. ; 125:3-4, s. 349-363
  • Journal article (peer-reviewed)abstract
    • The heat waves of 2003 in Western Europe and 2010 in Russia, commonly labelled as rare climatic anomalies outside of previous experience, are often taken as harbingers of more frequent extremes in the global warming-influenced future. However, a recent reconstruction of spring-summer temperatures for WE resulted in the likelihood of significantly higher temperatures in 1540. In order to check the plausibility of this result we investigated the severity of the 1540 drought by putting forward the argument of the known soil desiccation-temperature feedback. Based on more than 300 first-hand documentary weather report sources originating from an area of 2 to 3 million km(2), we show that Europe was affected by an unprecedented 11-month-long Megadrought. The estimated number of precipitation days and precipitation amount for Central and Western Europe in 1540 is significantly lower than the 100-year minima of the instrumental measurement period for spring, summer and autumn. This result is supported by independent documentary evidence about extremely low river flows and Europe-wide wild-, forest- and settlement fires. We found that an event of this severity cannot be simulated by state-of-the-art climate models.
  •  
47.
  • Abbasi, R., et al. (author)
  • A Combined Fit of the Diffuse Neutrino Spectrum using IceCube Muon Tracks and Cascades
  • 2022
  • In: 37th International Cosmic Ray Conference (ICRC 2021). - Trieste, Italy : Sissa Medialab Srl.
  • Conference paper (peer-reviewed)abstract
    • The IceCube Neutrino Observatory first observed a diffuse flux of high energy astrophysical neutrinos in 2013. Since then, this observation has been confirmed in multiple detection channels such as high energy starting events, cascades, and through-going muon tracks. Combining these event selections into a high statistics global fit of 10 years of IceCube's neutrino data could strongly improve the understanding of the diffuse astrophysical neutrino flux: challenging or confirming the simple unbroken power-law flux model as well as the astrophysical neutrino flux composition. One key component of such a combined analysis is the consistent modelling of systematic uncertainties of different event selections. This can be achieved using the novel SnowStorm Monte Carlo method which allows constraints to be placed on multiple systematic parameters from a single simulation set. We will report on the status of a new combined analysis of through-going muon tracks and cascades. It is based on a consistent all flavor neutrino signal and background simulation using, for the first time, the SnowStorm method to analyze IceCube's high-energy neutrino data. Estimated sensitivities for the energy spectrum of the diffuse astrophysical neutrino flux will be shown.
  •  
48.
  • Abbasi, R., et al. (author)
  • A model-independent analysis of neutrino flares detected in IceCube from X-ray selected blazars
  • 2022
  • In: 37th International Cosmic Ray Conference, ICRC2021. - Trieste, Italy : Proceedings of Science.
  • Conference paper (peer-reviewed)abstract
    • Blazars are among the most powerful steady sources in the Universe. Multi-messenger searches for blazars have traditionally focused on their gamma-ray emission, which can be produced simultaneously with neutrinos in photohadronic interactions. However, X-ray data can be equally vital to constrain the SED of these sources, since the hadronically co-produced gamma-rays could get absorbed by the ambient photon fields and cascade down to X-ray energies before escaping. In this work, we present the outline for an untriggered, time-dependent analysis of neutrino flares from the direction of X-ray selected blazars using 10 years of IceCube data. A binomial test will be performed on the population to reveal if a subcategory of sources has statistically significant emission. The sources are selected from RomaBZCat, and the p-values and best-fit flare parameters are obtained for each source using the method of unbinned likelihood maximisation.
  •  
49.
  • Abbasi, R., et al. (author)
  • A New Search for Neutrino Point Sources with IceCube
  • 2022
  • In: 37th International Cosmic Ray Conference (ICRC 2021). - Trieste, Italy : Sissa Medialab Srl.
  • Conference paper (peer-reviewed)abstract
    • The IceCube Neutrino Observatory, deployed inside the deep glacial ice at the South Pole, is the largest neutrino telescope in the world. While eight years have passed since IceCube discovered a diffuse flux of high-energy astrophysical neutrinos, the sources of the vast majority of these neutrinos remain unknown. Here, we present a new search for neutrino point sources that improves the accuracy of the statistical analysis, especially in the low energy regime. We replaced the usual Gaussian approximations of IceCube's point spread function with precise numerical representations, obtained from simulations, and combined them with new machine learning-based estimates of event energies and angular errors. Depending on the source properties, the new analysis provides improved source localization, flux characterization and thereby discovery potential (by up to 30%) over previous works. The analysis will be applied to IceCube data that has been recorded with the full 86-string detector configuration from 2011 to 2020 and includes improved detector calibration.
  •  
50.
  • Abbasi, R., et al. (author)
  • A next-generation optical sensor for IceCube-Gen2
  • 2022
  • In: 37th International Cosmic Ray Conference, ICRC2021. - Trieste, Italy : Proceedings of Science.
  • Conference paper (peer-reviewed)abstract
    • For the in-ice component of the next generation neutrino observatory at the South Pole, IceCube-Gen2, a new sensor module is being developed, which is an evolution of the D-Egg and mDOM sensors developed for the IceCube Upgrade. The sensor design features up to 18 4-inch PMTs distributed homogeneously in a borosilicate glass pressure vessel. Challenges arise for the mechanical design from the tight constraints on the bore hole diameter (which will be 2 inches smaller than for IceCube Upgrade) and from the close packing of the PMTs. The electronics design must meet the space constraints posed by the mechanical design as well as the power consumption and cost considerations from over 10,000 optical modules being deployed. This contribution presents forward-looking solutions to these design considerations. Prototype modules will be installed and integrated in the IceCube Upgrade.
  •  
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