| 1. |
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| 2. |
- Thomas, HS, et al.
(author)
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- 2019
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swepub:Mat__t
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| 8. |
- Drake, TM, et al.
(author)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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In: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Journal article (peer-reviewed)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 12. |
- Poley, L., et al.
(author)
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The ABC130 barrel module prototyping programme for the ATLAS strip tracker
- 2020
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In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 15:9
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Journal article (peer-reviewed)abstract
- For the Phase-II Upgrade of the ATLAS Detector [1], its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100% silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-250) [2, 3] and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.
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| 13. |
- Wadsworth, R., et al.
(author)
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THE NORTHWEST FRONTIER : SPECTROSCOPY OF N similar to Z NUCLEI BELOW MASS 100
- 2009
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In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 40:3, s. 611-620
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Journal article (peer-reviewed)abstract
- The spectroscopy and structure of excited states of N similar to Z nuclei in the mass 70-100 region has been investigated using two techniques. In the A similar to 70-80 region fusion evaporation reactions coupled with the recoil-beta-tagging method have been employed at Jyvaskyla to study low-lying states in odd-odd N = Z nuclei. Results from these and other data for known odd-odd nuclei above mass 60 will be discussed. In the heavier mass 90 region a fragmentation experiment has been performed using the RIS-ING/FRS setup at GSI. This experiment was primarily aimed at searching for spin gap isomers in nuclei around A similar to 96. The objectives of the latter experiment will be discussed.
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| 16. |
- Butterworth, J., et al.
(author)
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Les Houches 2013: Physics at TeV Colliders: Standard Model Working Group Report
- 2014
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Conference paper (peer-reviewed)abstract
- This Report summarizes the proceedings of the 2013 Les Houches workshop on Physics at TeV Colliders. Session 1 dealt primarily with (1) the techniques for calculating standard model multi-leg NLO and NNLO QCD and NLO EW cross sections and (2) the comparison of those cross sections with LHC data from Run 1, and projections for future measurements in Run 2.
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| 22. |
- Wang, Y., et al.
(author)
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Cloud formation in the atomic and molecular phase: H I self absorption (HISA) towards a giant molecular filament
- 2020
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 634
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Journal article (peer-reviewed)abstract
- Molecular clouds form from the atomic phase of the interstellar medium. However, characterizing the transition between the atomic and the molecular interstellar medium (ISM) is a complex observational task. Here we address cloud formation processes by combining HI self absorption (HISA) with molecular line data. Column density probability density functions (N-PDFs) are a common tool for examining molecular clouds. One scenario proposed by numerical simulations is that the N-PDF evolves from a log-normal shape at early times to a power-law-like shape at later times. To date, investigations of N-PDFs have been mostly limited to the molecular component of the cloud. In this paper, we study the cold atomic component of the giant molecular filament GMF38.1-32.4a (GMF38a, distance = 3.4 kpc, length similar to 230 pc), calculate its N-PDFs, and study its kinematics. We identify an extended HISA feature, which is partly correlated with the (CO)-C-13 emission. The peak velocities of the HISA and (CO)-C-13 observations agree well on the eastern side of the filament, whereas a velocity offset of approximately 4 km s(-1) is found on the western side. The sonic Mach number we derive from the linewidth measurements shows that a large fraction of the HISA, which is ascribed to the cold neutral medium (CNM), is at subsonic and transonic velocities. The column density of the CNM part is on the order of 10(20) to 10(21) cm(-2). The column density of molecular hydrogen, traced by (CO)-C-13, is an order of magnitude higher. The N-PDFs from HISA (CNM), HI emission (the warm and cold neutral medium), and (CO)-C-13 (molecular component) are well described by log-normal functions, which is in agreement with turbulent motions being the main driver of cloud dynamics. The N-PDF of the molecular component also shows a power law in the high column-density region, indicating self-gravity. We suggest that we are witnessing two different evolutionary stages within the filament. The eastern subregion seems to be forming a molecular cloud out of the atomic gas, whereas the western subregion already shows high column density peaks, active star formation, and evidence of related feedback processes.
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| 23. |
- Ademuyiwa, Adesoji O., et al.
(author)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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In: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Journal article (peer-reviewed)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 24. |
- Georgieva, M. N., et al.
(author)
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A tale of two tubeworms: taxonomy of vestimentiferans (Annelida: Siboglinidae) from the Mid-Cayman Spreading Centre
- 2023
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In: Invertebrate Systematics. - : CSIRO Publishing. - 1445-5226 .- 1447-2600. ; 37:3, s. 167-91
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Journal article (peer-reviewed)abstract
- The vestimentiferan tubeworm genera Lamellibrachia and Escarpia inhabit deep-sea chemosynthesis-based ecosystems, such as seeps, hydrothermal vents and organic falls, and have wide distributions across the Pacific, Atlantic and Indian Oceans. In 2010-2012 during initial explorations of hydro-thermal vents of the Mid-Cayman Spreading Centre (MCSC), both genera were found to co-occur at the Von Damm Vent Field (VDVF), a site characterised by diffuse flow, therefore resembling a hydrothermal seep'. Here, we erect two new vestimentiferan tubeworm species from the VDVF, Lamellibrachia judigobini sp. nov. and Escarpia tritentaculata sp. nov. Lamellibrachia judigobini sp. nov. differs genetically and morphologically from other Lamellibrachia species, and has a range that extends across the Gulf of Mexico, MCSC, off Trinidad and Tobago, and Barbados, and also across both vents and seeps and 964-3304-m water depth. Escarpia tritentaculata sp. nov. is distinguished from other Escarpia species primarily based on morphology and is known only from vents of the MCSC at 2300-m depth. This study highlights the incredible habitat flexibility of a single Lamellibrachia species and the genus Escarpia, and historic biogeographic connections to the eastern Pacific for L. judigobini sp. nov. and the eastern Atlantic for E. tritentaculata sp. nov.
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| 25. |
- Soler, J. D., et al.
(author)
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Histogram of oriented gradients: a technique for the study of molecular cloud formation
- 2019
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622
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Journal article (peer-reviewed)abstract
- We introduce the histogram of oriented gradients (HOG), a tool developed for machine vision that we propose as a new metric for the systematic characterization of spectral line observations of atomic and molecular gas and the study of molecular cloud formation models. In essence, the HOG technique takes as input extended spectral-line observations from two tracers and provides an estimate of their spatial correlation across velocity channels. We characterized HOG using synthetic observations of HI and (CO)-C-13(J = 1 -> 0) emission from numerical simulations of magnetohydrodynamic (MHD) turbulence leading to the formation of molecular gas after the collision of two atomic clouds. We found a significant spatial correlation between the two tracers in velocity channels where v(HI) approximate to v(13CO), almost independent of the orientation of the collision with respect to the line of sight. Subsequently, we used HOG to investigate the spatial correlation of the HI, from The HI/OH/recombination line survey of the inner Milky Way (THOR), and the (CO)-C-13(J = 1 -> 0) emission from the Galactic Ring Survey (GRS), toward the portion of the Galactic plane 33.degrees 75 <= l <= 35.degrees 25 and vertical bar b vertical bar <= 1.degrees 25. We found a significant spatial correlation between the two tracers in extended portions of the studied region. Although some of the regions with high spatial correlation are associated with HI self-absorption (HISA) features, suggesting that it is produced by the cold atomic gas, the correlation is not exclusive to this kind of region. The HOG results derived for the observational data indicate significant differences between individual regions: some show spatial correlation in channels around v(HI) approximate to v(13CO) while others present spatial correlations in velocity channels separated by a few kilometers per second. We associate these velocity offsets to the effect of feedback and to the presence of physical conditions that are not included in the atomic-cloud-collision simulations, such as more general magnetic field configurations, shear, and global gas infall.
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| 26. |
- Syed, J., et al.
(author)
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The "Maggie" filament: Physical properties of a giant atomic cloud
- 2022
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 657
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Journal article (peer-reviewed)abstract
- Context. The atomic phase of the interstellar medium plays a key role in the formation process of molecular clouds. Due to the line-of-sight confusion in the Galactic plane that is associated with its ubiquity, atomic hydrogen emission has been challenging to study. Aims. We investigate the physical properties of the "Maggie" filament, a large-scale filament identified in H I emission at line-of-sight velocities, upsilon(LSR) similar to -54 km s(-1). Methods. Employing the high-angular resolution data from The H I/OH Recombination line survey of the inner Milky Way (THOR), we have been able to study H I emission features at negative upsilon(LSR) velocities without any line-of-sight confusion due to the kinematic distance ambiguity in the first Galactic quadrant. In order to investigate the kinematic structure, we decomposed the emission spectra using the automated Gaussian fitting algorithm GAUSSPY+. Results. We identify one of the largest, coherent, mostly atomic H I filaments in the Milky Way. The giant atomic filament Maggie, with a total length of 1.2 +/- 0.1 kpc, is not detected in most other tracers, and it does not show signs of active star formation. At a kinematic distance of 17 kpc, Maggie is situated below (by approximate to 500 pc), but parallel to, the Galactic H I disk and is trailing the predicted location of the Outer Arm by 5-10 km s(-1) in longitude-velocity space. The centroid velocity exhibits a smooth gradient of less than +/- 3 km s(-1) (10 pc)(-1) and a coherent structure to within +/- 6 km s(-1). The line widths of similar to 10 km s(-1) along the spine of the filament are dominated by nonthermal effects. After correcting for optical depth effects, the mass of Maggie's dense spine is estimated to be 7.2(-1.9)(+2.5) x 10(5) M-circle dot. The mean number density of the filament is similar to 4 cm(-3), which is best explained by the filament being a mix of cold and warm neutral gas. In contrast to molecular filaments, the turbulent Mach number and velocity structure function suggest that Maggie is driven by transonic to moderately supersonic velocities that are likely associated with the Galactic potential rather than being subject to the effects of self-gravity or stellar feedback. The probability density function of the column density displays a log-normal shape around a mean of < N-HI > = 4.8 x 10(20) cm(-2), thus reflecting the absence of dominating effects of gravitational contraction. Conclusions. While Maggie's origin remains unclear, we hypothesize that Maggie could be the first in a class of atomic clouds that are the precursors of giant molecular filaments.
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| 27. |
- Abdesselam, A., et al.
(author)
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Boosted objects : a probe of beyond the standard model physics
- 2011
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:6, s. 1661-
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Journal article (peer-reviewed)abstract
- We present the report of the hadronic working group of the BOOST2010 workshop held at the University of Oxford in June 2010. The first part contains a review of the potential of hadronic decays of highly boosted particles as an aid for discovery at the LHC and a discussion of the status of tools developed to meet the challenge of reconstructing and isolating these topologies. In the second part, we present new results comparing the performance of jet grooming techniques and top tagging algorithms on a common set of benchmark channels. We also study the sensitivity of jet substructure observables to the uncertainties in Monte Carlo predictions.
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| 28. |
- Barnes, A. T., et al.
(author)
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LEGO - II. A 3mm molecular line study covering 100 pc of one of the most actively star-forming portions within the Milky Way disc
- 2020
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In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 497:2, s. 1972-2001
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Journal article (peer-reviewed)abstract
- The current generation of (sub)mm-telescopes has allowed molecular line emission to become a major tool for studying the physical, kinematic, and chemical properties of extragalactic systems, yet exploiting these observations requires a detailed understanding of where emission lines originate within the Milky Way. In this paper, we present 60'' (similar to 3pc) resolution observations of many 3mm-band molecular lines across a large map of the W49 massive star-forming region (similar to 100x100pc at 11kpc), which were taken as part of the 'LEGO' IRAM-30m large project. We find that the spatial extent or brightness of the molecular line transitions are not well correlated with their critical densities, highlighting abundance and optical depth must be considered when estimating line emission characteristics. We explore how the total emission and emission efficiency (i.e. line brightness per H-2 column density) of the line emission vary as a function of molecular hydrogen column density and dust temperature. We find that there is not a single region of this parameter space responsible for the brightest and most efficiently emitting gas for all species. For example, we find that the HCN transition shows high emission efficiency at high column density (10(22)cm(-2)) and moderate temperatures (35K), whilst e.g. N2H+ emits most efficiently towards lower temperatures (10(22)cm(-2); <20K). We determine XCO(1-0)similar to 0.3 x 10(20)cm(-2)(Kkms(-1))(-1), and alpha(HCN(1-0))similar to 30M(circle dot)(Kkms(-1)pc(2))(-1), which both differ significantly from the commonly adopted values. In all, these results suggest caution should be taken when interpreting molecular line emission.
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| 29. |
- Beuther, H., et al.
(author)
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OH maser emission in the THOR survey of the northern Milky Way
- 2019
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
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Journal article (peer-reviewed)abstract
- Context. OH masers trace diverse physical processes, from the expanding envelopes around evolved stars to star-forming regions or supernovae remnants. Providing a survey of the ground-state OH maser transitions in the northern hemisphere inner Milky Way facilitates the study of a broad range of scientific topics. Aims. We want to identify the ground-state OH masers at similar to 18 cm wavelength in the area covered by The HI/OH/Recombination line survey of the Milky Way (THOR). We will present a catalogue of all OH maser features and their possible associated environments. Methods. The THOR survey covers longitude and latitude ranges of 14 degrees.3 < l < 66 degrees.8 and b < +/- 1 degrees.25. All OH ground state lines (2)Pi(3/2) (J = 3/2) at 1612 (F = 1-2), 1665 (F = 1-1), 1667 (F = 2-2) and 1720 MHz (F = 2-1) have been observed, employing the Very Large Array (VLA) in its C configuration. The spatial resolution of the data varies between 12.5 '' and 19 '', the spectral resolution is 1.5 km s(-1), and the rms sensitivity of the data is similar to 10 mJy beam(-1) per channel. Results. We identify 1585 individual maser spots (corresponding to single spectral features) distributed over 807 maser sites (regions of size similar to 10(3)-10(4) AU). Based on different criteria from spectral profiles to literature comparison, we try to associate the maser sites with astrophysical source types. Approximately 51% of the sites exhibit the double-horned 1612 MHz spectra typically emitted from the expanding shells of evolved stars. The separations of the two main velocity features of the expanding shells typically vary between 22 and 38 km s(-1). In addition to this, at least 20% of the maser sites are associated with star-forming regions. While the largest fraction of 1720 MHz maser spots (21 out of 53) is associated with supernova remnants, a significant fraction of the 1720 MHz maser spots (17) are also associated with star-forming regions. We present comparisons to the thermal (CO)-C-13(1-0) emission as well as to other surveys of class II CH3OH and H2O maser emission. The catalogue attempts to present associations to astrophysical sources where available, and the full catalogue is available in electronic form. Conclusions. This OH maser catalogue presents a unique resource of stellar and interstellar masers in the northern hemisphere. It provides the basis for a diverse range of follow-up studies from envelopes around evolved stars to star-forming regions and Supernova remnants.
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| 30. |
- Giele, Walter, et al.
(author)
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The QCD / SM working group: Summary report
- 2002
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In: Physics at TeV colliders. Proceedings, Euro Summer School, Les Houches, France, May 21-June 1, 2001. ; , s. 275-426, s. 275-426
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Conference paper (other academic/artistic)
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| 35. |
- Singh, B. S. Nara, et al.
(author)
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Coulomb shifts and shape changes in the mass 70 region
- 2007
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 75:6
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Journal article (peer-reviewed)abstract
- The technique of recoil beta tagging has been developed which allows prompt gamma decays in nuclei from excited states to be correlated with electrons from their subsequent short-lived beta decay. This technique is ideal for studying nuclei very far from stability and improves in sensitivity for very short-lived decays and for high decay Q-values. The method has allowed excited states in Y-78 to be observed for the first time, as well as an extension in the knowledge of T=1 states in Rb-74. From this new information it has been possible to compare Coulomb energy differences (CED) between T=1 states in Br-70/Se-70, Rb-74/Kr-74, and Y-78/Sr-78. The A=70 CED exhibit an anomalous behavior which is inconsistent with all other known CED. This behavior may be accounted for qualitatively in terms of small variations in the Coulomb energy arising from shape changes.
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| 38. |
- Anderung, C., et al.
(author)
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A Swedish subfossil find of a bowhead whale from the late Pleistocene: shore displacement, paleoecology in south-west Sweden and the identity of the Swedenborg whale (Balaena swedenborgii Liljeborg, 1867)
- 2014
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In: Historical Biology. - : Informa UK Limited. - 0891-2963 .- 1029-2381. ; 26:1, s. 58-68
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Journal article (peer-reviewed)abstract
- The Swedenborg whale Balaena swedenborgii Liljeborg, 1867, is a baleen whale species believed to have existed in the North Sea from the period when the inland ice melted around 13,000 before present (BP) until about 8000 years ago. The first bones attributed to this species were found in Sweden in 1705. When whale remains were discovered on the Swedish west coast during the extension work of a motorway extension, it was speculated that this could be a specimen of the extinct Swedenborg whale. The bones were found 72m above the present-day sea level embedded in glacial mud. Shelly remains of marine organisms were present in the deposit surrounding the whale-fall, and sediments with the associated specimens were therefore collected for further analyses. We applied radiocarbon dating, thin sectioning, morphological analyses, ancient DNA typing and analyses of the associated shelly assemblage in an interdisciplinary effort to understand the circumstances of this fossil whale-fall. Our results show that the whale is not the putative species B. swedenborgii, but a bowhead whale Balaena mysticetus. The results also indicate that the whale must have been rapidly covered by glacial sediments, highlighting the speed of the deglacial process in the area.
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| 39. |
- Drennan, Regan, et al.
(author)
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Neanthes goodayi sp. nov. (Annelida, Nereididae), a remarkable new annelid species living inside deep-sea polymetallic nodules
- 2021
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In: European Journal of Taxonomy. - : Museum National D'Histoire Naturelle. - 2118-9773. ; 760, s. 160-185
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Journal article (peer-reviewed)abstract
- A new species of abyssal Neanthes Kinberg, 1865, N. goodayi sp. nov., is described from the Clarion-Clipperton Zone in the central Pacific Ocean, a region targeted for seabed mineral exploration for polymetallic nodules. It is a relatively large animal found living inside polymetallic nodules and in xenophyophores (giant Foraminifera) growing on nodules, highlighting the importance of the mineral resource itself as a distinct microhabitat. Neanthes goodayi sp. nov. can be distinguished from its congeners primarily by its distinctive, enlarged anterior pair of eyes in addition to characters of the head, pharynx and parapodia. Widespread, abundant, and easily recognisable, N. goodayi sp. nov. is also considered to be a suitable candidate as a potential indicator taxon for future monitoring of the impacts of seabed mining.
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| 40. |
- Glover, A. G., et al.
(author)
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A live video observatory reveals temporal processes at a shelf-depth whale-fall
- 2010
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In: Cahiers De Biologie Marine. - 0007-9723. ; 51:4, s. 375-381
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Journal article (peer-reviewed)abstract
- There have been very few studies of temporal processes at chemosynthetic ecosystems, even at relatively more accessible shallow water sites. Here we report the development and deployment of a simple cabled video observatory at 30 m water depth in Gullmarsfjorden, Sweden. The camera provides a live video feed to the internet of faunal activity in the experiments, which to date have included 5 separate whale-fall deployments. Our data suggest that the time to decomposition of small cetacean carcasses at shelf-depth settings is considerably slower than at deep-sea sites. We have also provided a new methodology for the deployment of low-cost live video observatories at up to 30 m water depth, which can be used both for research and outreach activities.
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| 41. |
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| 42. |
- Glover, Benedict M, et al.
(author)
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Impact of body mass index on the outcome of catheter ablation of atrial fibrillation
- 2019
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In: Heart. - : BMJ Publishing Group Ltd. - 1355-6037 .- 1468-201X. ; 105:3, s. 244-250
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Journal article (peer-reviewed)abstract
- OBJECTIVES: The association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges.METHODS: Baseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category.RESULTS: Among 3333 patients, 728 (21.8%) were classified as normal (BMI <25.0 kg/m2), 1537 (46.1%) as overweight (BMI 25.5-29.0 kg/m2) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m2). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p<0.001, respectively). An index BMI ≥30 kg/m2 led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112).CONCLUSIONS: Patients with a baseline BMI ≥30 kg/m2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
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| 43. |
- Gruhl, T., et al.
(author)
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Ultrafast structural changes direct the first molecular events of vision
- 2023
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 615, s. 939-944
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Journal article (peer-reviewed)abstract
- Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)(1). A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which isomerizes within 200 femtoseconds to the all-trans conformation(2), thereby initiating the cellular signal transduction processes that ultimately lead to vision. However, the intramolecular mechanism by which the photoactivated retinal induces the activation events inside rhodopsin remains experimentally unclear. Here we use ultrafast time-resolved crystallography at room temperature(3) to determine how an isomerized twisted all-trans retinal stores the photon energy that is required to initiate the protein conformational changes associated with the formation of the G protein-binding signalling state. The distorted retinal at a 1-ps time delay after photoactivation has pulled away from half of its numerous interactions with its binding pocket, and the excess of the photon energy is released through an anisotropic protein breathing motion in the direction of the extracellular space. Notably, the very early structural motions in the protein side chains of rhodopsin appear in regions that are involved in later stages of the conserved class A GPCR activation mechanism. Our study sheds light on the earliest stages of vision in vertebrates and points to fundamental aspects of the molecular mechanisms of agonist-mediated GPCR activation.
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| 44. |
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| 45. |
- Henshaw, Jonathan D., et al.
(author)
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Ubiquitous velocity fluctuations throughout the molecular interstellar medium
- 2020
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In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 4:11, s. 1064-1071
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Journal article (peer-reviewed)abstract
- The density structure of the interstellar medium determines where stars form and release energy, momentum and heavy elements, driving galaxy evolution1–4. Density variations are seeded and amplified by gas motion, but the exact nature of this motion is unknown across spatial scales and galactic environments5. Although dense star-forming gas probably emerges from a combination of instabilities6,7, convergent flows8 and turbulence9, establishing the precise origin is challenging because it requires gas motion to be quantified over many orders of magnitude in spatial scale. Here we measure10–12 the motion of molecular gas in the Milky Way and in nearby galaxy NGC 4321, assembling observations that span a spatial dynamic range 10−1–103 pc. We detect ubiquitous velocity fluctuations across all spatial scales and galactic environments. Statistical analysis of these fluctuations indicates how star-forming gas is assembled. We discover oscillatory gas flows with wavelengths ranging from 0.3–400 pc. These flows are coupled to regularly spaced density enhancements that probably form via gravitational instabilities13,14. We also identify stochastic and scale-free velocity and density fluctuations, consistent with the structure generated in turbulent flows9. Our results demonstrate that the structure of the interstellar medium cannot be considered in isolation. Instead, its formation and evolution are controlled by nested, interdependent flows of matter covering many orders of magnitude in spatial scale.
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| 46. |
- Jones, Daniel O.B., et al.
(author)
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Environment, ecology, and potential effectiveness of an area protected from deep-sea mining (Clarion Clipperton Zone, abyssal Pacific)
- 2021
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In: Progress in Oceanography. - : Elsevier BV. - 0079-6611. ; 197:September-October 2021
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Journal article (peer-reviewed)abstract
- To protect the range of habitats, species, and ecosystem functions in the Clarion Clipperton Zone (CCZ), a region of interest for deep-sea polymetallic nodule mining in the Pacific, nine Areas of Particular Environmental Interest (APEIs) have been designated by the International Seabed Authority (ISA). The APEIs are remote, rarely visited and poorly understood. Here we present and synthesise all available observations made at APEI-6, the most north eastern APEI in the network, and assess its representativity of mining contract areas in the eastern CCZ. The two studied regions of APEI-6 have a variable morphology, typical of the CCZ, with hills, plains and occasional seamounts. The seafloor is predominantly covered by fine-grained sediments, and includes small but abundant polymetallic nodules, as well as exposed bedrock. The oceanographic parameters investigated appear broadly similar across the region although some differences in deep-water mass separation were evident between APEI-6 and some contract areas. Sediment biogeochemistry is broadly similar across the area in the parameters investigated, except for oxygen penetration depth, which reached >2 m at the study sites within APEI-6, deeper than that found at UK1 and GSR contract areas. The ecology of study sites in APEI-6 differs from that reported from UK1 and TOML-D contract areas, with differences in community composition of microbes, macrofauna, xenophyophores and metazoan megafauna. Some species were shared between areas although connectivity appears limited. We show that, from the available information, APEI-6 is partially representative of the exploration areas to the south yet is distinctly different in several key characteristics. As a result, additional APEIs may be warranted and caution may need to be taken in relying on the APEI network alone for conservation, with other management activities required to help mitigate the impacts of mining in the CCZ.
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| 48. |
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| 49. |
- Kjeldgaard, Lisbeth, et al.
(author)
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Intramolecular vibronic dynamics in molecular solids: C60
- 2005
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In: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 72:20
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Journal article (peer-reviewed)abstract
- Vibronic coupling in solid C60 has been investigated with a combination of resonant photoemission spectroscopy (RPES) and resonant inelastic x-ray scattering (RIXS). Excitation as a function of energy within the lowest unoccupied molecular orbital resonance yielded strong oscillations in intensity and dispersion in RPES, and a strong inelastic component in RIXS. Reconciling these two observations establishes that vibronic coupling in this core hole excitation leads to predominantly inelastic scattering and localization of the excited vibrations on the molecule on a femtosecond time scale. The coupling extends throughout the widths of the frontier valence bands.
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