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1.	Perez, LG, et al. (author) Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5740- Journal article (other academic/artistic)abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
2.	Perez, LG, et al. (author) TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 2608- Journal article (peer-reviewed)abstract IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Huber, S. (2); Perez, D (2); Xu, H (2); Agalioti, T (2); Gagliani, N (2); Flavell, RA (2); show more...; Izbicki, JR (2); Bedke, T (2); Soukou, S (2); Vesely, MCA (2); McGee, HM (2); Brockmann, L (2); Steglich, B (2); Manthey, C (2); Seiz, O (2); Kempski, J (2); Diercks, BP (2); Guse, AH (2); Perez, LG (2); Pelzcar, P (2); Giannou, A (2); Konczalla, L (2); Wahib, R (2); Gnafakis, S (2); show less...

University: Karolinska Institutet (2)

Language: English (2)

Year: 2020 (2)

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