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1.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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2.
  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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3.
  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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4.
  • Bousquet, Jean, et al. (author)
  • Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
  • 2019
  • In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
  • Journal article (peer-reviewed)abstract
    • Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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7.
  • Forouzanfar, Mohammad H, et al. (author)
  • Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
  • 2015
  • In: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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8.
  • Naghavi, Mohsen, et al. (author)
  • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • In: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
  • Journal article (peer-reviewed)abstract
    • Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
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9.
  • Vos, Theo, et al. (author)
  • Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • In: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
  • Journal article (peer-reviewed)abstract
    • Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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10.
  • Santangelo, James S., et al. (author)
  • Global urban environmental change drives adaptation in white clover
  • 2022
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375
  • Journal article (peer-reviewed)abstract
    • Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural dines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale.
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11.
  • Blanton, Michael R., et al. (author)
  • Sloan Digital Sky Survey IV : Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
  • 2017
  • In: Astronomical Journal. - : IOP Publishing Ltd. - 0004-6256 .- 1538-3881. ; 154:1
  • Journal article (peer-reviewed)abstract
    • We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.
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12.
  • Abolfathi, Bela, et al. (author)
  • The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
  • 2018
  • In: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
  • Journal article (peer-reviewed)abstract
    • The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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13.
  • Axfors, Cathrine, et al. (author)
  • Association between convalescent plasma treatment and mortality in COVID-19 : a collaborative systematic review and meta-analysis of randomized clinical trials
  • 2021
  • In: BMC Infectious Diseases. - : BioMed Central (BMC). - 1471-2334. ; 21:1
  • Research review (peer-reviewed)abstract
    • Background: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, ). Methods: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I-2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.
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14.
  • Bousquet, Jean, et al. (author)
  • ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
  • 2021
  • In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
  • Research review (peer-reviewed)abstract
    • Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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17.
  • Spinoglio, L., et al. (author)
  • 2017
  • In: Publications Astronomical Society of Australia. - : Cambridge University Press (CUP). - 1323-3580 .- 1448-6083. ; 34
  • Journal article (peer-reviewed)abstract
    • IR spectroscopy in the range 12-230 mu m with the SPace IR telescope for Cosmology and Astrophysics (SPICA) will reveal the physical processes governing the formation and evolution of galaxies and black holes through cosmic time, bridging the gap between the James Webb Space Telescope and the upcoming Extremely Large Telescopes at shorter wavelengths and the Atacama Large Millimeter Array at longer wavelengths. The SPICA, with its 2.5-m telescope actively cooled to below 8 K, will obtain the first spectroscopic determination, in the mid-IR rest-frame, of both the star-formation rate and black hole accretion rate histories of galaxies, reaching lookback times of 12 Gyr, for large statistically significant samples. Densities, temperatures, radiation fields, and gas-phase metallicities will be measured in dust-obscured galaxies and active galactic nuclei, sampling a large range in mass and luminosity, from faint local dwarf galaxies to luminous quasars in the distant Universe. Active galactic nuclei and starburst feedback and feeding mechanisms in distant galaxies will be uncovered through detailed measurements of molecular and atomic line profiles. The SPICA's large-area deep spectrophotometric surveys will provide mid-IR spectra and continuum fluxes for unbiased samples of tens of thousands of galaxies, out to redshifts of z similar to 6.
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18.
  • Cicone, C., et al. (author)
  • Massive molecular outflows and evidence for AGN feedback from CO observations
  • 2014
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 562, s. 25-
  • Journal article (peer-reviewed)abstract
    • We study the properties of massive, galactic-scale outflows of molecular gas and investigate their impact on galaxy evolution. We present new IRAMPdBI CO(1-0) observations of local ultra-luminous infrared galaxies (ULIRGs) and quasar-hosts: a clear signature of massive and energetic molecular outflows, extending on kpc scales, is found in the CO(1-0) kinematics of four out of seven sources, with measured outflow rates of several 100M(circle dot)yr(-1). We combine these new observations with data from the literature, and explore the nature and origin of massive molecular outflows within an extended sample of 19 local galaxies. We find that starburst-dominated galaxies have an outflow rate comparable to their star formation rate (SFR), or even higher by a factor of similar to 2-4, implying that starbursts can indeed be effective in removing cold gas from galaxies. Nevertheless, our results suggest that the presence of an active galactic nucleus (AGN) can boost the outflow rate by a large factor, which is found to increase with the L-AGN/L-bol ratio. The gas depletion time scales due to molecular outflows are anti-correlated with the presence and luminosity of an AGN in these galaxies, and range from a few hundred million years in starburst galaxies down to just a few million years in galaxies hosting powerful AGNs. In quasar hosts, the depletion time scales due to the outflow are much shorter than the depletion time scales due to star formation. We estimate the outflow kinetic power and find that, for galaxies hosting powerful AGNs, it corresponds to about 5% of the AGN luminosity, as expected by models of AGN feedback. Moreover, we find that momentum rates of about 20 L-AGN/c are common among the AGN-dominated sources in our sample. For "pure" starburst galaxies, our data tentatively support models in which outflows are mostly momentum-driven by the radiation pressure from young stars onto dusty clouds. Overall, our results indicate that, although starbursts are effective in powering massive molecular outflows, the presence of an AGN may strongly enhance such outflows, and therefore have a profound feedback effect on the evolution of galaxies by efficiently removing fuel for star formation, hence quenching star formation.
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19.
  • Franco, Maximilian, et al. (author)
  • The ramp-up of interstellar medium enrichment at z > 4
  • 2021
  • In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 5, s. 1240-1246
  • Journal article (peer-reviewed)abstract
    • Fluorine is one of the most interesting elements for nuclear and stellar astrophysics1,2. Fluorine abundance was first measured for stars other than the Sun in 19921, then for a handful of metal-poor stars3, which are likely to have formed in the early Universe. The main production sites of fluorine are under debate and include asymptotic giant branch stars, the ν-process in core-collapse supernovae, and Wolf–Rayet stars4,5,6,7,8,9,10. Due to the difference in the mass and lifetime of progenitor stars, high-redshift observations of fluorine can help constrain the mechanism of fluorine production in massive galaxies. Here, we report the detection of HF (signal-to-noise ratio of 8) in absorption in a gravitationally lensed dusty star-forming galaxy at redshift z = 4.4 with NHF/NH2NH2 as high as ~2 × 10−9, indicating a very quick ramp-up of the chemical enrichment in this high-z galaxy. At z = 4.4, asymptotic giant branch stars of a few solar masses are very unlikely to dominate the enrichment. Instead, we show that Wolf–Rayet stars are required to produce the observed fluorine abundance at this time, with other production mechanisms becoming important at later times. These observations therefore provide an insight into the underlying processes driving the ramp-up phase of chemical enrichment alongside rapid stellar mass assembly in a young massive galaxy.
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20.
  • Gonzalez-Alfonso, E., et al. (author)
  • The Mrk 231 molecular outflow as seen in OH
  • 2014
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 561, s. Article no. A27-
  • Journal article (peer-reviewed)abstract
    • We report on the Herschel/PACS observations of OH in Mrk 231, with detections in nine doublets observed within the PACS range, and present radiative-transfer models for the outflowing OH. Clear signatures of outflowing gas are found in up to six OH doublets with different excitation requirements. At least two outflowing components are identified, one with OH radiatively excited, and the other with low excitation, presumably spatially extended and roughly spherical. Particularly prominent, the blue wing of the absorption detected in the in-ladder (2)Pi(3/2) J = 9/2-7/2 OH doublet at 65 mu m, with E-lower = 290 K, indicates that the excited outflowing gas is generated in a compact and warm (circum) nuclear region. Because the excited, outflowing OH gas in Mrk 231 is associated with the warm, far-infrared continuum source, it is most likely more compact (diameter of similar to 200-300 pc) than that probed by CO and HCN. Nevertheless, its mass-outflow rate per unit of solid angle as inferred from OH is similar to that previously derived from CO, greater than or similar to 70 x (2.5 x 10(-6)/X-OH) M-circle dot yr(-1) sr(-1), where X-OH is the OH abundance relative to H nuclei. In spherical symmetry, this would correspond to greater than or similar to 850 x (2.5 x 10(-6)/X-OH) M-circle dot yr(-1), though significant collimation is inferred from the line profiles. The momentum flux of the excited component attains similar to 15 L-AGN/c, with an OH column density of (1.5-3) x 10(17) cm(-2) and a mechanical luminosity of similar to 10(11) L-circle dot. In addition, the detection of very excited, radiatively pumped OH peaking at central velocities indicates the presence of a nuclear reservoir of gas rich in OH, plausibly the 130 pc scale circumnuclear torus previously detected in OH megamaser emission, that may be feeding the outflow. An exceptional (OH)-O-18 enhancement, with OH/(OH)-O-18 less than or similar to 30 at both central and blueshifted velocities, is most likely the result of interstellar-medium processing by recent starburst and supernova activity within the circumnuclear torus or thick disk.
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21.
  • Manzoni, Claudia, et al. (author)
  • Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
  • 2024
  • In: American Journal of Human Genetics. - 0002-9297. ; 111:7, s. 1316-1329
  • Journal article (peer-reviewed)abstract
    • Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10−12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10−12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10−8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
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22.
  • Privon, G., et al. (author)
  • A hard x-ray test of hcn enhancements as a tracer of embedded black hole growth
  • 2020
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 893:2
  • Journal article (peer-reviewed)abstract
    • Enhanced emission from the dense gas tracer HCN (relative to HCO+) has been proposed as a signature of active galactic nuclei (AGN). In a previous single-dish millimeter line survey we identified galaxies with HCN/HCO+ (1-0) intensity ratios consistent with those of many AGN but whose mid-infrared spectral diagnostics are consistent with little to no (≲15%) contribution of an AGN to the bolometric luminosity. To search for putative heavily obscured AGN, we present and analyze NuSTAR hard X-ray (3-79 keV) observations of four such galaxies from the Great Observatories All-sky LIRG Survey. We find no X-ray evidence for AGN in three of the systems and place strong upper limits on the energetic contribution of any heavily obscured (NH > 1024 cm-2) AGN to their bolometric luminosity. The upper limits on the X-ray flux are presently an order of magnitude below what XDR-driven chemistry models predict are necessary to drive HCN enhancements. In a fourth system we find a hard X-ray excess consistent with the presence of an AGN, but contributing only ∼3% of the bolometric luminosity. It is also unclear if the AGN is spatially associated with the HCN enhancement. We further explore the relationship between HCN/HCO+ (for several J upper levels) and LAGN/LIR f for a larger sample of systems in the literature. We find no evidence for correlations between the line ratios and the AGN fraction derived from X-rays, indicating that HCN/HCO+ intensity ratios are not driven by the energetic dominance of AGN, nor are they reliable indicators of ongoing supermassive black hole accretion. © 2020. The American Astronomical Society. All rights reserved
  •  
23.
  • The Seventeenth Data Release of the Sloan Digital Sky Surveys : Complete Release of MaNGA, MaStar, and APOGEE-2 Data
  • 2022
  • In: Astrophysical Journal Supplement Series. - : Institute of Physics (IOP). - 0067-0049 .- 1538-4365. ; 259:2
  • Journal article (peer-reviewed)abstract
    • This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys.
  •  
24.
  • Aalto, Susanne, 1964, et al. (author)
  • Probing highly obscured, self-absorbed galaxy nuclei with vibrationally excited HCN
  • 2015
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 584
  • Journal article (peer-reviewed)abstract
    • We present high resolution (0.'' 4) IRAM PdBI and ALMA mm and submm observations of the (ultra) luminous infrared galaxies ((U)LIRGs) IRAS 17208-0014, Arp220, IC 860 and Zw049.057 that reveal intense line emission from vibrationally excited (nu(2) = 1) J = 3-2 and 4-3 HCN. The emission is emerging from buried, compact (r 5 x 10(13) L-circle dot kpc(-2). These nuclei are likely powered by accreting supermassive black holes (SMBHs) and/or hot (>200 K) extreme starbursts. Vibrational, nu(2) = 1, lines of HCN are excited by intense 14 mu m mid-infrared emission and are excellent probes of the dynamics, masses, and physical conditions of (U)LIRG nuclei when H-2 column densities exceed 10(24) cm(-2). It is clear that these lines open up a new interesting avenue to gain access to the most obscured AGNs and starbursts. Vibrationally excited HCN acts as a proxy for the absorbed mid-infrared emission from the embedded nuclei, which allows for reconstruction of the intrinsic, hotter dust SED. In contrast, we show strong evidence that the ground vibrational state (. = 0), J = 3-2 and 4-3 rotational lines of HCN and HCO+ fail to probe the highly enshrouded, compact nuclear regions owing to strong self-and continuum absorption. The HCN and HCO+ line profiles are double-peaked because of the absorption and show evidence of non-circular motions-possibly in the form of in-or outflows. Detections of vibrationally excited HCN in external galaxies are so far limited to ULIRGs and early-type spiral LIRGs, and we discuss possible causes for this. We tentatively suggest that the peak of vibrationally excited HCN emission is connected to a rapid stage of nuclear growth, before the phase of strong feedback.
  •  
25.
  • Aladro, Rebeca, 1979, et al. (author)
  • Molecular gas in the northern nucleus of Mrk 273: Physical and chemical properties of the disc and its outflow
  • 2018
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 617
  • Journal article (peer-reviewed)abstract
    • Aiming to characterise the properties of the molecular gas in the ultra-luminous infrared galaxy Mrk 273 and its outflow, we used the NOEMA interferometer to image the dense-gas molecular tracers HCN, HCO+, HNC, HOC+ and HC3N at similar to 86 GHz and similar to 256 GHz with angular resolutions of 4.'' 9 x 4.'' 5 (similar to 3.7 x 3.4 kpc) and 0.'' 61 x 0.'' 55 (similar to 460 x 420 pc). We also modelled the flux of several H2O lines observed with Herschel using a radiative transfer code that includes excitation by collisions and far-infrared photons. The disc of the Mrk 273 north nucleus has two components with decoupled kinematics. The gas in the outer parts (R similar to 1.5 kpc) rotates with a south-east to north-west direction, while in the inner disc (R similar to 300 pc) follows a north-east to south-west rotation. The central 300 pc, which hosts a compact starburst region, is filled with dense and warm gas, and contains a dynamical mass of (4-5) x 10(9) M-circle dot, a luminosity of L'HCN = (3-4) x 10(8) K km s(-1) pc(2), and a dust temperature of 55 K. At the very centre, a compact core with R similar to 50 pc has a luminosity of LIR = 4 x 10(11) L-circle dot (30% of the total infrared luminosity), and a dust temperature of 95 K. The core is expanding at low velocities similar to 50-100 km s(-1), probably affected by the outflowing gas. We detect the blue-shifted component of the outflow, while the red-shifted counterpart remains undetected in our data. Its cold and dense phase reaches fast velocities up to similar to 1000 km s(-1), while the warm outflowing gas has more moderate maximum velocities of similar to 600 km s(-1). The outflow is compact, being detected as far as 460 pc from the centre in the northern direction, and has a mass of dense gas <= 8 x 10(8) M-circle dot. The difference between the position angles of the inner disc (similar to 70 degrees) and the outflow (similar to 10 degrees) indicates that the outflow is likely powered by the AGN, and not by the starburst. Regarding the chemistry in Mrk 273, we measure an extremely low HCO+/HOC+ ratio of 10 +/- 5 in the inner disc of Mrk 273.
  •  
26.
  • Alfonso, Fernando, et al. (author)
  • Authorship : From credit to accountability - Reflections from the Editors' network.
  • 2019
  • In: Archivos de cardiologia de Mexico. - 1665-1731. ; 89:1, s. 93-99
  • Journal article (peer-reviewed)abstract
    • The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new -(fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.
  •  
27.
  • Alfonso, Fernando, et al. (author)
  • Authorship : From credit to accountability - Reflections from the Editors' network.
  • 2019
  • In: Archivos de cardiologia de Mexico. - 1665-1731. ; 89:2, s. 105-111
  • Journal article (peer-reviewed)abstract
    • The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new -(fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.
  •  
28.
  • Basso, C., et al. (author)
  • Improved dengue fever prevention through innovative intervention methods in the city of Salto, Uruguay
  • 2015
  • In: Transactions of the Royal Society of Tropical Medicine and Hygiene. - : Oxford University Press (OUP). - 0035-9203 .- 1878-3503. ; 109:2, s. 134-142
  • Journal article (peer-reviewed)abstract
    • Background: Uruguay is located at the southern border of Aedes aegypti distribution on the South American sub-continent. The reported dengue cases in the country are all imported from surrounding countries. One of the cities at higher risk of local dengue transmission is Salto, a border city with heavy traffic from dengue endemic areas. Methods: We completed an intervention study using a cluster randomized trial design in 20 randomly selected 'clusters' in Salto. The clusters were located in neighborhoods of differing geography and economic, cultural and social aspects. Results: Entomological surveys were carried out to measure the impact of the intervention on vector densities. Through participatory processes of all stakeholders, an appropriate ecosystem management intervention was defined. Residents collected the abundant small water holding containers and the Ministry of Public Health and the Municipality of Salto were responsible for collecting and eliminating them. Additional vector breeding places were large water tanks; they were either altered so that they could not hold water any more or covered so that oviposition by mosquitoes could not take place. Conclusions: The response from the community and national programme managers was encouraging. The intervention evidenced opportunities for cost savings and reducing dengue vector densities (although not to statistically significant levels). The observed low vector density limits the potential reduction due to the intervention. A larger sample size is needed to obtain a statistically significant difference.
  •  
29.
  • Basso, C., et al. (author)
  • Scaling up of an innovative intervention to reduce risk of dengue, chikungunya, and Zika transmission in Uruguay in the framework of an intersectoral approach with and without community participation
  • 2017
  • In: American Journal of Tropical Medicine and Hygiene. - : American Society of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 97:5, s. 1428-1436
  • Journal article (peer-reviewed)abstract
    • To contribute to the prevention of dengue, chikungunya, and Zika, a process of scaling up an innovative intervention to reduce Aedes aegypti habitats, was carried out in the city of Salto (Uruguay) based on a transdisciplinary analysis of the eco-bio-social determinants. The intervention in one-third of the city included the distributions of plastic bags for all households to collect all discarded water containers that were recollected by the Ministry of Health and the Municipality vector control services. The results were evaluated in 20 randomly assigned clusters of 100 households each, in the intervention and control arm. The intervention resulted in a significantly larger decrease in the number of pupae per person index (as a proxy for adult vector abundance) than the corresponding decrease in the control areas (both areas decreased by winter effects). The reduction of intervention costs (“incremental costs”) in relation to routine vector control activities was 46%. Community participation increased the collaboration with the intervention program considerably (from 48% of bags handed back out of the total of bags delivered to 59% of bags handed back). Although the costs increased by 26% compared with intervention without community participation, the acceptability of actions by residents increased from 66% to 78%.
  •  
30.
  • Beal, Jacob, et al. (author)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Journal article (peer-reviewed)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
  •  
31.
  • Bousquet, J. Jean, et al. (author)
  • Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
  • 2019
  • In: Clinical and Translational Allergy. - : BMC. - 2045-7022. ; 9
  • Research review (peer-reviewed)abstract
    • Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
  •  
32.
  • Crowson, Cynthia S., et al. (author)
  • Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
  • 2018
  • In: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 77:1, s. 48-54
  • Journal article (peer-reviewed)abstract
    • Objectives: Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD). We aimed to assess the impact of CVD risk factors, including potential sex differences, and RA-specific variables on CVD outcome in a large, international cohort of patients with RA. Methods: In 13 rheumatology centres, data on CVD risk factors and RA characteristics were collected at baseline. CVD outcomes (myocardial infarction, angina, revascularisation, stroke, peripheral vascular disease and CVD death) were collected using standardised definitions. Results: 5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p<0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics). Conclusions: In a large, international cohort of patients with RA, 30% of CVD events were attributable to RA characteristics. This finding indicates that RA characteristics play an important role in efforts to reduce CVD risk among patients with RA.
  •  
33.
  • Davies, Stuart J., et al. (author)
  • ForestGEO: Understanding forest diversity and dynamics through a global observatory network
  • 2021
  • In: Biological Conservation. - : Elsevier BV. - 0006-3207. ; 253
  • Journal article (peer-reviewed)abstract
    • ForestGEO is a network of scientists and long-term forest dynamics plots (FDPs) spanning the Earth's major forest types. ForestGEO's mission is to advance understanding of the diversity and dynamics of forests and to strengthen global capacity for forest science research. ForestGEO is unique among forest plot networks in its large-scale plot dimensions, censusing of all stems ≥1 cm in diameter, inclusion of tropical, temperate and boreal forests, and investigation of additional biotic (e.g., arthropods) and abiotic (e.g., soils) drivers, which together provide a holistic view of forest functioning. The 71 FDPs in 27 countries include approximately 7.33 million living trees and about 12,000 species, representing 20% of the world's known tree diversity. With >1300 published papers, ForestGEO researchers have made significant contributions in two fundamental areas: species coexistence and diversity, and ecosystem functioning. Specifically, defining the major biotic and abiotic controls on the distribution and coexistence of species and functional types and on variation in species' demography has led to improved understanding of how the multiple dimensions of forest diversity are structured across space and time and how this diversity relates to the processes controlling the role of forests in the Earth system. Nevertheless, knowledge gaps remain that impede our ability to predict how forest diversity and function will respond to climate change and other stressors. Meeting these global research challenges requires major advances in standardizing taxonomy of tropical species, resolving the main drivers of forest dynamics, and integrating plot-based ground and remote sensing observations to scale up estimates of forest diversity and function, coupled with improved predictive models. However, they cannot be met without greater financial commitment to sustain the long-term research of ForestGEO and other forest plot networks, greatly expanded scientific capacity across the world's forested nations, and increased collaboration and integration among research networks and disciplines addressing forest science.
  •  
34.
  • Gonzalez-Alfonso, E., et al. (author)
  • Herschel observations of water vapour in Markarian 231
  • 2010
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L43
  • Journal article (peer-reviewed)abstract
    • The Ultra luminous infrared galaxy (ULIRG) Mrk 231 reveals up to seven rotational lines of water (H2O) in emission, including a very high-lying (Eupper = 640 K) line detected at a 4 sigma level, within the Herschel/SPIRE wavelength range (190
  •  
35.
  • Gonzalez-Alfonso, E., et al. (author)
  • HIGH-LYING OH ABSORPTION, [C II] DEFICITS, AND EXTREME LFIR/MH2 RATIOS IN GALAXIES
  • 2015
  • In: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 800:1, s. 1-10
  • Journal article (peer-reviewed)abstract
    • Herschel/PACS observations of 29 local (ultra) luminous infrared galaxies, including both starburst and active galactic nucleus (AGN) dominated sources as diagnosed in the mid-infrared/optical, show that the equivalent width of the absorbing OH 65 mu m.3/2 J = 9/2-7/2 line (Weq(OH65)) with lower level energy Elow 300 K, is anticorrelated with the [Cii] 158 mu m line to far-infrared luminosity ratio, and correlated with the far-infrared luminosity per unit gas mass and with the 60-to-100 mu m far-infrared color. While all sources are in the active LIR/MH2 > 50L /M mode as derived from previous CO line studies, the OH65 absorption shows a bimodal distribution with a discontinuity at LFIR/MH2 100L /M . In the most buried sources, OH65 probes material partially responsible for the silicate 9.7 mu m absorption. Combined with observations of the OH 71 mu m.1/2 J = 7/2-5/2 doublet (Elow 415 K), radiative transfer models characterized by the equivalent dust temperature, Tdust, and the continuum optical depth at 100 mu m, t100, indicate that strong [C ii] 158 mu m deficits are associated with far-IR thick (t100 0.7, NH 1024 cm-2), warm (Tdust 60 K) structures where the OH 65 mu m absorption is produced, most likely in circumnuclear disks/tori/cocoons. With their high LFIR/MH2 ratios and columns, the presence of these structures is expected to give rise to strong [C ii] deficits. Weq(OH65) probes the fraction of infrared luminosity arising from these compact/warm environments, which is 30%-50% in sources with high Weq(OH65). Sources with high Weq(OH65) have surface densities of both LIR and MH2 higher than inferred from the half-light (CO or UV/optical) radius, tracing coherent structures that represent the most buried/active stage of (circum) nuclear starburst-AGN co-evolution.
  •  
36.
  • Gonzalez-Alfonso, E., et al. (author)
  • Molecular Outflows in Local ULIRGs: Energetics from Multitransition OH Analysis
  • 2017
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 836:1
  • Journal article (peer-reviewed)abstract
    • We report on the energetics of molecular outflows in 14 local ultraluminous infrared galaxies (ULIRGs) that show unambiguous outflow signatures (P Cygni profiles or high-velocity absorption wings) in the far-infrared lines of OH measured with the Herschel/PACS spectrometer. All sample galaxies are gas-rich mergers at various stages of the merging process. Detection of both ground-state (at 119 and 79 mu m) and one or more radiatively excited (at 65 and 84 mu m) lines allows us to model the nuclear gas (. 300 pc) and the more extended components using spherically symmetric radiative transfer models. Reliable models and the corresponding energetics are found in 12 of the 14 sources. The highest molecular outflow velocities are found in buried sources, in which slower but massive expansion of the nuclear gas is also observed. With the exception of a few outliers, the outflows have momentum fluxes of (2-5) x L-IR/c and mechanical luminosities of (0.1-0.3)% of L-IR. The moderate momentum boosts in these sources (. 3) suggest that the outflows are mostly momentum driven by the combined effects of active galactic nuclei (AGNs) and nuclear starbursts, as a result of radiation pressure, winds, and supernova remnants. In some sources ( similar to 20%), however, powerful (10(10.5- 11) L circle dot) AGN feedback and (partially) energy-conserving phases are required, with momentum boosts in the range of 3-20. These outflows appear to be stochastic, strong AGN feedback events that occur throughout the merging process. In a few sources, the outflow activity in the innermost regions has subsided in the past similar to 1 Myr. While OH traces the molecular outflows at subkiloparsec scales, comparison of the masses traced by OH with those previously inferred from tracers of more extended outflowing gas suggests that most mass is loaded (with loading factors of M/SFR = 1-10) from the central galactic cores (a few. x. 100 pc), qualitatively consistent with an ongoing inside-out quenching of star formation. Outflow depletion timescales are
  •  
37.
  • Greve, T. R., et al. (author)
  • Star Formation Relations and CO-Spectral Line Energy Distributions Across the J-Ladder and Redshift
  • 2014
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 794:2, s. Art. no. 142-
  • Journal article (peer-reviewed)abstract
    • We present FIR [50-300 mu m]-CO luminosity relations (i.e., log L-FIR = alpha log L'(CO) + beta) for the full CO rotational ladder from J = 1-0 up to J = 13-12 for a sample of 62 local (z 10(11) L-circle dot) using data from Herschel SPIRE-FTS and ground-based telescopes. We extend our sample to high redshifts (z > 1) by including 35 submillimeter selected dusty star forming galaxies from the literature with robust CO observations, and sufficiently well-sampled FIR/submillimeter spectral energy distributions (SEDs), so that accurate FIR luminosities can be determined. The addition of luminous starbursts at high redshifts enlarge the range of the FIR-CO luminosity relations toward the high-IR-luminosity end, while also significantly increasing the small amount of mid-J/high-J CO line data (J = 5-4 and higher) that was available prior to Herschel. This new data set (both in terms of IR luminosity and J-ladder) reveals linear FIR-CO luminosity relations (i.e., a similar or equal to 1) for J = 1-0 up to J = 5-4, with a nearly constant normalization (beta similar to 2). In the simplest physical scenario, this is expected from the (also) linear FIR-(molecular line) relations recently found for the dense gas tracer lines (HCN and CS), as long as the dense gas mass fraction does not vary strongly within our (merger/starburst)-dominated sample. However, from J = 6-5 and up to the J = 13-12 transition, we find an increasingly sublinear slope and higher normalization constant with increasing J. We argue that these are caused by a warm (similar to 100 K) and dense (>10(4) cm(-3)) gas component whose thermal state is unlikely to be maintained by star-formation-powered far-UV radiation fields (and thus is no longer directly tied to the star formation rate). We suggest that mechanical heating (e.g., supernova-driven turbulence and shocks), and not cosmic rays, is the more likely source of energy for this component. The global CO spectral line energy distributions, which remain highly excited from J = 6-5 up to J = 13-12, are found to be a generic feature of the (U)LIRGs in our sample, and further support the presence of this gas component.
  •  
38.
  • Lutz, D., et al. (author)
  • Molecular outflows in local galaxies: Method comparison and a role of intermittent AGN driving
  • 2020
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 633
  • Journal article (peer-reviewed)abstract
    • We report new detections and limits from a NOEMA and ALMA CO(1-0) search for molecular outflows in 13 local galaxies with high far-infrared surface brightness, and combine these with local universe CO outflow results from the literature. The CO line ratios and spatial outflow structure of our targets provide some constraints on the conversion steps from observables to physical quantities such as molecular mass outflow rates. Where available, ratios between outflow emission in higher J CO transitions and in CO(1-0) are typically consistent with excitation R-i1 less than or similar to 1. However, for IRAS 13120 5453, R-31 = 2.10 +/- 0.29 indicates optically thin CO in the outflow. Like much of the outflow literature, we use ff CO(1 0) = 0.8, and we present arguments for using C = 1 in deriving molecular mass outflow rates. (M)over dot(out) = CM(out)v(out)/R-out. We compare the two main methods for molecular outflow detection: CO millimeter interferometry and Herschel OH-based spectroscopic outflow searches. For 26 sources studied with both methods, we find an 80% agreement in detecting vout & 150 km s 1 outflows, and non-matches can be plausibly ascribed to outflow geometry and signal-to-noise ratio. For a published sample of 12 bright ultraluminous infrared galaxies with detailed OH-based outflow modeling, CO outflows are detected in all but one. Outflow masses, velocities, and sizes for these 11 sources agree well between the two methods, and modest remaining di fferences may relate to the di fferent but overlapping regions sampled by CO emission and OH absorption. Outflow properties correlate better with active galactic nucleus (AGN) luminosity and with bolometric luminosity than with far-infrared surface brightness. The most massive outflows are found for systems with current AGN activity, but significant outflows in nonAGN systems must relate to star formation or to AGN activity in the recent past. We report scaling relations for the increase of outflow mass, rate, momentum rate, and kinetic power with bolometric luminosity. Short flow times of similar to 10(6) yr and some sources with resolved multiple outflow episodes support a role of intermittent driving, likely by AGNs.
  •  
39.
  • Privon, G., et al. (author)
  • The Dense Molecular Gas and Nuclear Activity in the ULIRG IRAS 13120-5453
  • 2017
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 835:2, s. Article Number: 213-
  • Journal article (peer-reviewed)abstract
    • We present new Atacama Large Millimeter/submillimeter Array Band 7 (?340 GHz) observations of the dense gas tracers HCN, HCO+, and CS in the local, single-nucleus, ultraluminous infrared galaxy IRAS 13120-5453. We find centrally enhanced HCN (4-3) emission, relative to HCO+ (4-3), but do not find evidence for radiative pumping of HCN. Considering the size of the starburst (0.5 kpc) and the estimated supernovae rate of ?1.2 yr-1, the high HCN/HCO+ ratio can be explained by an enhanced HCN abundance as a result of mechanical heating by the supernovae, though the active galactic nucleus and winds may also contribute additional mechanical heating. The starburst size implies a high ?IR of 4.7 × 1012 L? kpc-2, slightly below predictions of radiation-pressure limited starbursts. The HCN line profile has low-level wings, which we tentatively interpret as evidence for outflowing dense molecular gas. However, the dense molecular outflow seen in the HCN line wings is unlikely to escape the Galaxy and is destined to return to the nucleus and fuel future star formation. We also present modeling of Herschel observations of the H2O lines and find a nuclear dust temperature of ?40 K. IRAS 13120-5453 has a lower dust temperature and ?IR than is inferred for the systems termed "compact obscured nuclei (CONs)" (such as Arp 220 and Mrk 231). If IRAS 13120-5453 has undergone a CON phase, we are likely witnessing it at a time when the feedback has already inflated the nuclear ISM and diluted star formation in the starburst/active galactic nucleus core.
  •  
40.
  • Quinatoa, Daysi, et al. (author)
  • The first ground-based detection of the 752 GHz water line in local ultraluminous infrared galaxies using APEX-SEPIA
  • 2024
  • In: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 527:3, s. 6321-6331
  • Journal article (peer-reviewed)abstract
    • We report the first ground-based detection of the water line p-H2O (211-202) at 752.033 GHz in three z < 0.08 ultraluminous infrared galaxies (ULIRGs): IRAS 06035-7102, IRAS 17207-0014, and IRAS 09022-3615. Using the Atacama Pathfinder EXperiment (APEX), with its Swedish-ESO PI Instrument for APEX (SEPIA) band-9 receiver, we detect this H2O line with overall signal-to-noise ratios of 8-10 in all three galaxies. Notably, this is the first detection of this line in IRAS 06035-7102. Our new APEX-measured fluxes, between 145 and 705 Jy km s-1, are compared with previous values taken from Herschel SPIRE FTS. We highlight the great capabilities of APEX for resolving the H2O line profiles with high spectral resolutions while also improving by a factor of two the significance of the detection within moderate integration times. While exploring the correlation between the p-H2O(211-202) and the total infrared luminosity, our galaxies are found to follow the trend at the bright end of the local ULIRG's distribution. The p-H2O(211-202) line spectra are compared to the mid-J CO and HCN spectra, and dust continuum previously observed with ALMA. In the complex interacting system IRAS 09022-3615, the profile of the water emission line is offset in velocity with respect to the ALMA CO(J = 4-3) emission. For IRAS 17207-0014 and IRAS 06035-7102, the profiles between the water line and the CO lines are spectroscopically aligned. This pilot study demonstrates the feasibility of directly conducting ground-based high-frequency observations of this key water line, opening the possibility of detailed follow-up campaigns to tackle its nature.
  •  
41.
  • Rosenberg, M. J. F., et al. (author)
  • The Herschel Comprehensive (U)lirg Emission Survey (Hercules): Co Ladders, Fine Structure Lines, and Neutral Gas Cooling
  • 2015
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 801:2
  • Journal article (peer-reviewed)abstract
    • (Ultra) luminous infrared galaxies ((U)LIRGs) are objects characterized by their extreme infrared (8-1000 mu m) luminosities (L-LIRG > 10(11) L-circle dot and L-ULIRG > 10(12) L-circle dot). The Herschel Comprehensive ULIRG Emission Survey (PI: van derWerf) presents a representative flux-limited sample of 29 (U)LIRGs that spans the full luminosity range of these objects (10(11)L(circle dot)
  •  
42.
  • van der Werf, P.P., et al. (author)
  • Black hole accretion and star formation as drivers of gas excitation and chemistry in Markarian 231
  • 2010
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L42
  • Journal article (peer-reviewed)abstract
    • We present a full high resolution SPIRE FTS spectrum of the nearby ultraluminous infrared galaxy Mrk 231. In total 25 lines are detected, including CO J = 5-4 through J = 13-12, 7 rotational lines of H2O, 3 of OH+ and one line each of H2O+, CH+, and HF. We find that the excitation of the CO rotational levels up to J = 8 can be accounted for by UV radiation from star formation. However, the approximately flat luminosity distribution of the CO lines over the rotational ladder above J = 8 requires the presence of a separate source of excitation for the highest CO lines. We explore X-ray heating by the accreting supermassive black hole in Mrk 231 as a source of excitation for these lines, and find that it can reproduce the observed luminosities. We also consider a model with dense gas in a strong UV radiation field to produce the highest CO lines, but find that this model strongly overpredicts the hot dust mass in Mrk 231. Our favoured model consists of a star forming disk of radius 560 pc, containing clumps of dense gas exposed to strong UV radiation, dominating the emission of CO lines up to J = 8. X-rays from the accreting supermassive black hole in Mrk 231 dominate the excitation and chemistry of the inner disk out to a radius of 160 pc, consistent with the X-ray power of the AGN in Mrk 231. The extraordinary luminosity of the OH+ and H2O+ lines reveals the signature of X-ray driven excitation and chemistry in this region.
  •  
43.
  • Yang, C., et al. (author)
  • Submillimeter H 2 O and H 2 O + emission in lensed ultra- and hyper-luminous infrared galaxies at z ~ 2-4
  • 2016
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 595, s. Art no A80-
  • Journal article (peer-reviewed)abstract
    • We report rest-frame submillimeter H2O emission line observations of 11 ultra- or hyper-luminous infrared galaxies (ULIRGs or HyLIRGs) at z ∼ 2-4 selected among the brightest lensed galaxies discovered in the Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS). Using the IRAM NOrthern Extended Millimeter Array (NOEMA), we have detected 14 new H2O emission lines. These include five 321-312 ortho-H2O lines (Eup/k = 305 K) and nine J = 2 para-H2O lines, either 202-111 (Eup/k = 101 K) or 211-202 (Eup/k = 137 K). The apparent luminosities of the H2O emission lines are μLH2O ∼ 6-21 × 108 L⊙ (3 > μ > 15, where μ is the lens magnification factor), with velocity-integrated line fluxes ranging from 4-15 Jy km s-1. We have also observed CO emission lines using EMIR on the IRAM 30 m telescope in seven sources (most of those have not yet had their CO emission lines observed). The velocity widths for CO and H2O lines are found to be similar, generally within 1σ errors in the same source. With almost comparable integrated flux densities to those of the high-J CO line (ratios range from 0.4 to 1.1), H2O is found to be among the strongest molecular emitters in high-redshift Hy/ULIRGs. We also confirm our previously found correlation between luminosity of H2O(LH2O) and infrared (LIR) that LH2O ∼ LIR1:1-1:2, with our new detections. This correlation could be explained by a dominant role of far-infrared pumping in the H2O excitation. Modelling reveals that the far-infrared radiation fields have warm dust temperature Twarm ∼ 45-75 K, H2O column density per unit velocity interval NH2O/ΔV ≳ 0:3 × 1015 cm-2 km-1 s and 100 μm continuum opacity τ100 1 (optically thick), indicating that H2O is likely to trace highly obscured warm dense gas. However, further observations of J ≥ 4 H2O lines are needed to better constrain the continuum optical depth and other physical conditions of the molecular gas and dust. We have also detected H2O+ emission in three sources. A tight correlation between LH2O and LH2O+ has been found in galaxies from low to high redshift. The velocity-integrated flux density ratio between H2O+ and H2O suggests that cosmic rays generated by strong star formation are possibly driving the H2O+ formation. © 2016 ESO.
  •  
44.
  • Aalto, Susanne, 1964, et al. (author)
  • High resolution observations of HCN and HCO+J = 3–2 in the disk and outflow of Mrk 231 -- Detection of vibrationally excited HCN in the warped nucleus
  • 2015
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 574, s. 85-
  • Journal article (peer-reviewed)abstract
    • Aims. Our goal is to study molecular gas properties in nuclei and large scale outflows/winds from active galactic nuclei (AGNs) and starburst galaxies.Methods. We obtained high resolution (0.̋25 to 0.̋90) observations of HCN and HCO+J = 3 → 2 of the ultraluminous QSO galaxy Mrk 231 with the IRAM Plateau de Bure Interferometer (PdBI).Results. We find luminous HCN and HCO+J = 3 → 2 emission in the main disk and we detect compact (r ≲ 0''̣1 (90 pc)) vibrationally excited HCN J = 3 → 2ν2 = 1f emission centred on the nucleus. The velocity field of the vibrationally excited HCN is strongly inclined (position angle PA = 155°) compared to the east-west rotation of the main disk. The nuclear (r ≲ 0.̋1) molecular mass is estimated to 8 × 108 M⊙ with an average N(H2) of 1.2 × 1024 cm-2. Prominent, spatially extended (≳350 pc) line wings are found for HCN J = 3 → 2 with velocities up to ± 750 km s-1. Line ratios indicate that the emission is emerging in dense gas n = 104−5 × 105 cm-3 of elevated HCN abundance X(HCN) = 10-8−10-6. The highest X(HCN) also allows for the emission to originate in gas of more moderate density. We tentatively detect nuclear emission from the reactive ion HOC+ with HCO+/HOC+ = 10−20.Conclusions. The HCN ν2 = 1f line emission is consistent with the notion of a hot, dusty, warped inner disk of Mrk 231 where the ν2 = 1f line is excited by bright mid-IR 14 μm continuum. We estimate the vibrational temperature Tvib to 200−400 K. Based on relative source sizes we propose that 50% of the main HCN emission may have its excitation affected by the radiation field through IR pumping of the vibrational ground state. The HCN emission in the line wings, however, is more extended and thus likely not strongly affected by IR pumping. Our results reveal that dense clouds survive (and/or are formed) in the AGN outflow on scales of at least several hundred pc before evaporating or collapsing. The elevated HCN abundance in the outflow is consistent with warm chemistry possibly related to shocks and/or X-ray irradiated gas. An upper limit to the mass and momentum flux is 4 × 108 M⊙ and 12LAGN/c, respectively, and we discuss possible driving mechanisms for the dense outflow.
  •  
45.
  • Falstad, Niklas, 1987, et al. (author)
  • CON-quest: Searching for the most obscured galaxy nuclei
  • 2021
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 649
  • Journal article (peer-reviewed)abstract
    • Context. Some luminous and ultraluminous infrared galaxies (LIRGs and ULIRGs) host extremely compact (r < 100 pc) and dusty nuclei. The high extinction associated with large column densities of gas and dust toward these objects render them hard to detect at many wavelengths. The intense infrared radiation arising from warm dust in these sources can provide a significant fraction of the bolometric luminosity of the galaxy and is prone to excite vibrational levels of molecules such as HCN. This results in emission from the rotational transitions of vibrationally excited HCN (HCN-vib); the brightest emission is found in compact obscured nuclei (CONs; ςHCN-vib > 1 L⊙ pc-2 in the J = 3-2 transition). However, there have been no systematic searches for CONs, and it is unknown how common they are. Aims. We aim to establish how common CONs are in the local Universe (z < 0.08), and whether their prevalence depends on the luminosity or other properties of the host galaxy. Methods. We conducted an Atacama Large Millimeter/submillimeter Array survey of the rotational J = 3-2 transition of HCN-vib in a volume-limited sample of 46 far-infrared luminous galaxies. Results. Compact obscured nuclei are identified in 38-13+18% of the ULIRGs, 21-6+12% of the LIRGs, and 0-0+9% of the lower luminosity galaxies. We find no dependence on the inclination of the host galaxy, but strong evidence of lower IRAS 25 μm to 60 μm flux density ratios (f25/f60) in CONs (with the exception of one galaxy, NGC 4418) compared to the rest of the sample. Furthermore, we find that CONs have stronger silicate features (s9.7 μm), but similar polycyclic aromatic hydrocarbon equivalent widths (EQW6.2 μm) compared to other galaxies. Along with signatures of molecular inflows seen in the far-infrared in most CONs, submillimeter observations also reveal compact, often collimated, outflows. Conclusions. In the local Universe, CONs are primarily found in (U)LIRGs, in which they are remarkably common. As such systems are often highly disturbed, inclinations are difficult to estimate, and high-resolution continuum observations of the individual nuclei are required to determine if the CON phenomenon is related to the inclinations of the nuclear disks. Further studies of the in- A nd outflow properties of CONs should also be conducted to investigate how these are connected to each other and to the CON phenomenon. The lower f25/f60 ratios in CONs as well as the results for the mid-infrared diagnostics investigated (EQW6.2 μm and s9.7 μm) are consistent with the notion that large dust columns gradually shift the radiation from the hot nucleus to longer wavelengths, making the mid- A nd far-infrared "photospheres"significantly cooler than the interior regions. Finally, to assess the importance of CONs in the context of galaxy evolution, it is necessary to extend this study to higher redshifts where (U)LIRGs are more common.
  •  
46.
  • Falstad, Niklas, 1987, et al. (author)
  • Herschel spectroscopic observations of the compact obscured nucleus in Zw 049.057
  • 2015
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 580, s. A52-
  • Journal article (peer-reviewed)abstract
    • Context. The luminous infrared galaxy Zw 049.057 contains a compact obscured nucleus where a considerable amount of the galaxy's luminosity is generated. This nucleus contains a dusty environment that is rich in molecular gas. One approach to probing this kind of environment and to revealing what is hidden behind the dust is to study the rotational lines of molecules that couple well with the infrared radiation emitted by the dust. Aims. We probe the physical conditions in the core of Zw 049.057 and establish the nature of its nuclear power source (starburst or active galactic nucleus). Methods. We observed Zw 049.057 with the Photodetector Array Camera and Spectrometer (PACS) and the Spectral and Photometric Imaging Receiver (SPIRE) onboard the Herschel Space Observatory in rotational lines of H2O, H218O, OH, 18OH, and [O I]. We modeled the unresolved core of the galaxy using a spherically symmetric radiative transfer code. To account for the different excitation requirements of the various molecular transitions, we use multiple components and different physical conditions. Results. We present the full high-resolution SPIRE FTS spectrum of Zw 049.057, along with relevant spectral scans in the PACS range. We find that a minimum of two different components (nuclear and extended) are required in order to account for the rich molecular line spectrum of Zw 049.057. The nuclear component has a radius of 10-30 pc, a very high infrared surface brightness (∼1014L⊙kpc-2), warm dust (Td > 100 K), and a very large H2 column density (NH2 = 1024-1025 cm-2). The modeling also indicates high nuclear H2O (∼5 × 10-6) and OH (∼4 × 10-6) abundances relative to H2 as well as a low 16O/18O-ratio of 50-100. We also find a prominent infall signature in the [O I] line. We tentatively detect a 500 km s-1 outflow in the H2O 313 → 202 line. Conclusions. The high surface brightness of the core indicates the presence of either a buried active galactic nucleus or a very dense nuclear starburst. The estimated column density towards the core of Zw 049.057 indicates that it is Compton-thick, making a buried X-ray source difficult to detect even in hard X-rays. We discuss the elevated H2O abundance in the nucleus in the context of warm grain and gas-phase chemistry. The H2O abundance is comparable to that of other compact (ultra-)luminous infrared galaxies such as NGC 4418 and Arp 220 - and also to hot cores in the Milky Way. The enhancement of 18O is a possible indicator that the nucleus of Zw 049.057 is in a similar evolutionary stage as the nuclei of Arp 220 - and more advanced than NGC 4418. We discuss the origin of the extreme nuclear gas concentration and note that the infalling gas detected in [O I] implies that the gas reservoir in the central region of Zw 049.057 is being replenished. If confirmed, the H2O outflow suggests that the nucleus is in a stage of rapid evolution.
  •  
47.
  • Falstad, Niklas, 1987, et al. (author)
  • Herschel spectroscopic observations of Zw 049.057 and Arp 299a
  • 2016
  • In: Proceedings of the International Astronomical Union. - : Cambridge University Press (CUP). - 1743-9213 .- 1743-9221. - 9781107135208 ; 315
  • Conference paper (peer-reviewed)abstract
    • The presence of compact obscured nuclei in luminous infrared galaxies (LIRGs) is very well probed by the detection of highly excited absorption lines of OH and H2O in the far-infrared (far-IR), which require warm and optically thick dust to pump the high-lying rotational levels. We are using a spherically symmetric radiative transfer code to model the H2O lines, OH lines and continuum from these objects. We discuss the results and analysis of Herschel observations of the compact obscured nucleus in the extremely H2O luminous LIRG Zw 049.057. In this galaxy we have found very high H2O abundances in a Compton thick compact core. Abundant O-18 bearing species also suggest the presence of a relatively young starburst. We compare this to our observations and modeling of the luminous merger component Arp 299a, which is another source with prominent H2O and OH lines. Our preliminary results, however, suggest that its nuclear activity is in a different evolutionary state compared to Zw 049.057.
  •  
48.
  • Falstad, Niklas, 1987, et al. (author)
  • Hidden molecular outflow in the LIRG Zw 049.057
  • 2018
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 609
  • Journal article (peer-reviewed)abstract
    • Context. Feedback in the form of mass outflows driven by star formation or active galactic nuclei is a key component of galaxy evolution. The luminous infrared galaxy Zw 049.057 harbours a compact obscured nucleus with a possible far-infrared signature of outflowing molecular gas. Due to the high optical depths at far-infrared wavelengths, however, the interpretation of the outflow signature is uncertain. At millimeter and radio wavelengths, the radiation is better able to penetrate the large columns of gas and dust responsible for the obscuration. Aims. We aim to investigate the molecular gas distribution and kinematics in the nucleus of Zw 049.057 in order to confirm and locate the molecular outflow, with the ultimate goal to understand how the nuclear activity affects the host galaxy. Methods. We used high angular resolution observations from the Submillimeter Array (SMA), the Atacama Large Millimeter/submillimeter Array (ALMA), and the Karl G. Jansky Very Large Array (VLA) to image the CO J = 2-1 and J = 6-5 emission, the 690 GHz continuum, the radio centimeter continuum, and absorptions by rotationally excited OH. Results. The CO line profiles exhibit wings extending ~ 300 km s -1 beyond the systemic velocity. At centimeter wavelengths, we find a compact (~ 40 pc) continuum component in the nucleus, with weaker emission extending several 100 pc approximately along the major and minor axes of the galaxy. In the OH absorption lines toward the compact continuum, wings extending to a similar velocity as for the CO are only seen on the blue side of the profile. The weak centimeter continuum emission along the minor axis is aligned with a highly collimated, jet-like dust feature previously seen in near-infrared images of the galaxy. Comparison of the apparent optical depths in the OH lines indicate that the excitation conditions in Zw 049.057 differ from those within other OH megamaser galaxies. Conclusions. We interpret the wings in the spectral lines as signatures of a nuclear molecular outflow. A relation between this outflow and the minor axis radio feature is possible, although further studies are required to investigate this possible association and understand the connection between the outflow and the nuclear activity. Finally, we suggest that the differing OH excitation conditions are further evidence that Zw 049.057 is in a transition phase between megamaser and kilomaser activity.
  •  
49.
  • Falstad, Niklas, 1987, et al. (author)
  • Hidden or missing outflows in highly obscured galaxy nuclei?
  • 2019
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 623
  • Journal article (peer-reviewed)abstract
    • Understanding the nuclear growth and feedback processes in galaxies requires investigating their often obscured central regions. One way to do this is to use (sub)millimeter line emission from vibrationally excited HCN (HCN-vib), which is thought to trace warm and highly enshrouded galaxy nuclei. It has been suggested that the most intense HCN-vib emission from a galaxy is connected to a phase of nuclear growth that occurs before the nuclear feedback processes have been fully developed. Aims. We aim to investigate if there is a connection between the presence of strong HCN-vib emission and the development of feedback in (ultra)luminous infrared galaxies ((U)LIRGs). Methods. We collected literature and archival data to compare the luminosities of rotational lines of HCN-vib, normalized to the total infrared luminosity, to the median velocities of 119 μm OH absorption lines, potentially indicating outflows, in a total of 17 (U)LIRGs. Results. The most HCN-vib luminous systems all lack signatures of significant molecular outflows in the far-infrared OH absorption lines. However, at least some of the systems with bright HCN-vib emission have fast and collimated outflows that can be seen in spectral lines at longer wavelengths, including in millimeter emission lines of CO and HCN (in its vibrational ground state) and in radio absorption lines of OH. Conclusions. We conclude that the galaxy nuclei with the highest L HCN-vib /L IR do not drive wide-angle outflows that are detectable using the median velocities of far-infrared OH absorption lines. This is possibly because of an orientation effect in which sources oriented in such a way that their outflows are not along our line of sight also radiate a smaller proportion of their infrared luminosity in our direction. It could also be that massive wide-angle outflows destroy the deeply embedded regions responsible for bright HCN-vib emission, so that the two phenomena cannot coexist. This would strengthen the idea that vibrationally excited HCN traces a heavily obscured stage of evolution before nuclear feedback mechanisms are fully developed.
  •  
50.
  • Falstad, Niklas, 1987, et al. (author)
  • Inflowing gas onto a compact obscured nucleus in Arp 299A: Herschel spectroscopic studies of H 2 O and OH
  • 2017
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 597:1 January, s. Article number A105-
  • Journal article (peer-reviewed)abstract
    • Aims. We probe the physical conditions in the core of Arp 299A and try to put constraints on the nature of its nuclear power source. Methods. We used Herschel Space Observatory far-infrared and submillimeter observations of H2O and OH rotational lines in Arp 299A to create a multi-component model of the galaxy. In doing this, we employed a spherically symmetric radiative transfer code. Results. Nine H2O lines in absorption and eight in emission, as well as four OH doublets in absorption and one in emission, are detected in Arp 299A. No lines of the 18O isotopologues, which have been seen in compact obscured nuclei of other galaxies, are detected. The absorption in the ground state OH 2?3/2-2?3/2(5/2)+-(3/2)-?3/22-2?3/2 52+-32-doublet at 119 ?m is found redshifted by ? 175 km s-1 compared with other OH and H2O lines, suggesting a low excitation inflow. We find that at least two components are required in order to account for the excited molecular line spectrum. The inner component has a radius of 20-25 pc, a very high infrared surface brightness (3 × 1013L·kpc-2), warm dust (Td > 90 K), and a large H2 column density (NH2 > 1024 cm-2). The modeling also indicates high nuclear H2O (1-5 × 10-6) and OH (0.5-5 × 10-5) abundances relative to H nuclei. The outer component is larger (50-100 pc) with slightly cooler dust (70-90 K) and molecular abundances that are approximately one order of magnitude lower. In addition to the two components that account for the excited OH and H2O lines, we require a much more extended inflowing component to account for the OH 2?3/2-2?3/2(5/2)+-(3/2)- ?3/22-2?3/2 52+-32-doublet at 119 ?m. Conclusions. The Compton-thick nature of the core makes it difficult to determine the nature of the buried power source, but the high surface brightness indicates that it is an active galactic nucleus and/or a dense nuclear starburst. Our results are consistent with a composite source. The high OH/H2O ratio in the nucleus indicates that ion-neutral chemistry induced by X-rays or cosmic-rays is important. Finally we find a lower limit to the 16O/18O ratio of 400 in the nuclear region, possibly indicating that the nuclear starburst is in an early evolutionary stage, or that it is fed through a molecular inflow of, at most, solar metallicity.
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