| 1. |
- Gyllenberg, A, et al.
(author)
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Variability in the CIITA gene interacts with HLA in multiple sclerosis.
- 2014
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In: Genes and immunity. - Stockholm : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 15, s. 162-167
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Journal article (peer-reviewed)abstract
- The human leukocyte antigen (HLA) is the main genetic determinant of multiple sclerosis (MS) risk. Within the HLA, the class II HLA-DRB1*15:01 allele exerts a disease-promoting effect, whereas the class I HLA-A*02 allele is protective. The CIITA gene is crucial for expression of class II HLA molecules and has previously been found to associate with several autoimmune diseases, including MS and type 1 diabetes. We here performed association analyses with CIITA in 2000 MS cases and up to 6900 controls as well as interaction analysis with HLA. We find that the previously investigated single-nucleotide polymorphism rs4774 is associated with MS risk in cases carrying the HLA-DRB1*15 allele (P=0.01, odds ratio (OR): 1.21, 95% confidence interval (CI): 1.04-1.40) or the HLA-A*02 allele (P=0.01, OR: 1.33, 95% CI: 1.07-1.64) and that these associations are independent of the adjacent confirmed MS susceptibility gene CLEC16A. We also confirm interaction between rs4774 and HLA-DRB1*15:01 such that individuals carrying the risk allele for rs4774 and HLA-DRB1*15:01 have a higher than expected risk for MS. In conclusion, our findings support previous data that variability in the CIITA gene affects MS risk, but also that the effect is modulated by MS-associated HLA haplotypes. These findings further underscore the biological importance of HLA for MS risk.Genes and Immunity advance online publication, 16 January 2014; doi:10.1038/gene.2013.71.
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| 2. |
- Sedimbi, S. K., et al.
(author)
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SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients
- 2007
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In: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 518-21
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Journal article (peer-reviewed)abstract
- SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.
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| 3. |
- Shin, J. H., et al.
(author)
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IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
- 2007
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In: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 503-12
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Journal article (peer-reviewed)abstract
- In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.
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| 4. |
- Landin-Olsson, Mona, et al.
(author)
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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls
- 1990
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In: Pancreas. - : Ovid Technologies (Wolters Kluwer Health). - 0885-3177. ; 5:3, s. 241-247
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Journal article (peer-reviewed)abstract
- To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.
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| 5. |
- Sanjeevi, Carani B., et al.
(author)
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The risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group are different in different regions of Sweden
- 2008
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In: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. - 9781573317337 ; 1150, s. 106-11
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Journal article (peer-reviewed)abstract
- HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP. The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six geographical regions, subjects from Stockholm had the highest OR, followed by those from Lund, Linköping, Gothenburg, Umeå, and Uppsala. Absolute protection was conferred by the presence of DQ6 in subjects from the Linköping region, but varied in the other regions. The frequency of DR3 and DQ2, DR4 and DQ8, DR15, and DQ6 in patients showed high linkage for each region, but were different between regions. In conclusion: The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden. The results highlight the important role played by the various environmental factors in the precipitation of T1D.
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| 6. |
- Sun, Chengjun, et al.
(author)
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CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
- 2012
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In: Human Immunology. - : Elsevier. - 0198-8859 .- 1879-1166. ; 73:7, s. 759-766
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.
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| 7. |
- Watanabe, A, et al.
(author)
-
Gunnar Fant 60 years
- 1979
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In: TMH-QPSR. ; 20:2, s. 1-45
-
Journal article (peer-reviewed)
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| 8. |
- Bertenstam, J, et al.
(author)
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THE WAXHOLM APPLICATION DATABASE
- 1995
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Conference paper (peer-reviewed)abstract
- This paper describes an application database collected in Wizard-of-Oz experiments in a spoken dialogue system, WAXHOLM. The system provides information on boat traffic in the Stockholm archipelago. The database consists of utterance-length speech files, their corressonding transcriptions, and log files of the dialogue sessions. In addition to the spontaneous dialogue speech, the material also comprise recordings of phonetically balanced reference sentences uttered by all 66 subjects. In the paper the recording procedure is described as well as some characteristics of the speech data and the dialogue.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
- Styrud, J, et al.
(author)
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Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial
- 2006
-
In: World Journal of Surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 30:6, s. 1033-1037
-
Journal article (peer-reviewed)abstract
- Background Appendectomy has been the treatment for acute appendicitis for over 120 years. Antibiotic treatment has occasionally been used in small uncontrolled studies, instead of operation, but this alternative has never before been tried in a multicenter randomized trial. Patients and Methods Male patients, 18–50 years of age, admitted to six different hospitals in Sweden between 1996 and 1999 were enrolled in the study. No women were enrolled by decision of the local ethics committee. If appendectomy was planned, patients were asked to participate, and those who agreed were randomized either to surgery or to antibiotic therapy. Patients randomized to surgery were operated on with open surgery or laparoscopically. Those randomized to antibiotic therapy were treated intravenously for 2 days, followed by oral treatment for 10 days. If symptoms did not resolve within 24 hours, an appendectomy was performed. Participants were monitored at the end of 1 week, 6 weeks, and 1 year. Results During the study period 252 men participated, 124 in the surgery group and 128 in the antibiotic group. The frequency of appendicitis was 97% in the surgery group and 5% had a perforated appendix. The complication rate was 14% in the surgery group. In the antibiotic group 86% improved without surgery; 18 patients were operated on within 24 hours, and the diagnosis of acute appendicitis was confirmed in all but one patient, and he was suffering from terminal ileitis. There were seven patients (5%) with a perforated appendix in this group. The rate of recurrence of symptoms of appendicitis among the 111 patients treated with antibiotics was 14% during the 1-year follow-up. Conclusions Acute nonperforated appendicitis can be treated successfully with antibiotics. However, there is a risk of recurrence in cases of acute appendicitis, and this risk should be compared with the risk of complications after appendectomy.
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| 13. |
- Bjørnland, Kristin, et al.
(author)
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A Nordic multicenter survey of long-term bowel function after transanal endorectal pull-through in 200 patients with rectosigmoid Hirschsprung disease
- 2017
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In: Journal of Pediatric Surgery. - : Elsevier BV. - 1531-5037 .- 0022-3468. ; 52:9, s. 1458-1464
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: Transanal endorectal pull-through (ERPT) is the most popular technique to treat Hirschsprung disease (HD). Still, there is limited knowledge on long-term bowel function. This cross-sectional, multicenter study assessed long-term bowel function in a large HD population and examined predictors of poor outcome.METHODS: Patients older than four years or their parents filled out a validated questionnaire on bowel function. Clinical details were recorded retrospectively from medical records.RESULTS: 73/200 (37%) patients reported absolutely no impaired bowel function, meaning no constipation, fecal accidents, stoma, appendicostomy or need for enemas. Seven (4%) had a stoma, and 33 (17%) used antegrade or rectal colonic enemas. Most disarrangements of fecal control and constipation were significantly less common in older age group, but abnormal defecation frequency and social problems remained unchanged. Syndromic patients (n=31) experienced frequent fecal accidents (46%) more often than nonsyndromic (14%, P<0.001). Having a syndrome (adjusted OR 5.6, 95% CI 2.1-15, P=0.001) or a complete transanal ERPT (adjusted OR 2.4, 95% CI 1.1-5.7, P=0.038) was significantly associated with poor outcome defined as having a stoma, an appendicostomy, daily fecal accidents or need of regular rectal wash outs.CONCLUSION: A significant number of HD patients experience bowel problems many years after definite surgery. Fecal control was significantly better in older than younger HD patients, but some continued to have considerable bowel problems also as adults. A total transanal ERPT was associated with poorer outcome. Long-term follow-up of HD patients is warranted. Prognosis Study: Level II.
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| 14. |
- Blomberg, Mats, et al.
(author)
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An experimental dialog system: WAXHOLM
- 1993
-
Conference paper (peer-reviewed)abstract
- Recently we have begun to build the basic tools for a generic speech-dialogue system, WAXHOLM. The main modules, their function and internal communication have been specified. The different components are connected through a computer network. A preliminary version of the system has been tested, using simplified versions of the modules. We will give a general overview of the system and describe some of the components in more detail. Application specific data are collected with the help of Wizard-of-Oz techniques. The dialogue system is used during the data collection and the wizard only replaces the speechrecognition module.
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| 15. |
- Blomberg, Mats, et al.
(author)
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Speech recognition based on a text-to-speech synthesis system
- 1987
-
Conference paper (peer-reviewed)abstract
- A major problem in large-vocabulary speech recognition is the collection of reference data and speaker normalization. In this paper we propose the use of synthetic speech as a means of handling this problem. An experimental scheme for such a system will be described.
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| 16. |
- Blomberg, Mats, et al.
(author)
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Speech synthesis and recognition in technical aids
- 1986
-
In: STL-QPSR. ; 27:4, s. 45-65
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Journal article (peer-reviewed)abstract
- A number of speech-producing technical aids arenowavailable for use by disabled individuals. One system which produces synthetic speech is described and its application in technical aids discussed. These applications inclde a communication aid, a symbol-to-speech system, talking terminals and a daily newspaper. A pattern-matching speech recognition system is also described and its future in the area of technical aids discussed.
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| 17. |
- Brandis, Gerrit, 1985-, et al.
(author)
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Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
- 2021
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 76:3, s. 606-615
-
Journal article (peer-reviewed)abstract
- BackgroundMutations in RNA polymerase (RNAP) can reduce susceptibility to ciprofloxacin in Escherichia coli, but the mechanism of transcriptional reprogramming responsible is unknown. Strains carrying ciprofloxacin-resistant (CipR) rpoB mutations have reduced growth fitness and their impact on clinical resistance development is unclear.ObjectivesTo assess the potential for CipRrpoB mutations to contribute to resistance development by estimating the number of distinct alleles. To identify fitness-compensatory mutations that ameliorate the fitness costs of CipRrpoB mutations. To understand how CipRrpoB mutations reprogramme RNAP.MethodsE. coli strains carrying five different CipRrpoB alleles were evolved with selection for improved fitness and characterized for acquired mutations, relative fitness and MICCip. The effects of dksA mutations and a ppGpp0 background on growth and susceptibility phenotypes associated with CipRrpoB alleles were determined.ResultsThe number of distinct CipRrpoB mutations was estimated to be >100. Mutations in RNAP genes and in dksA can compensate for the fitness cost of CipRrpoB mutations. Deletion of dksA reduced the MICCip for strains carrying CipRrpoB alleles. A ppGpp0 phenotype had no effect on drug susceptibility.ConclusionsCipRrpoB mutations induce an ppGpp-independent stringent-like response. Approximately half of the reduction in ciprofloxacin susceptibility is caused by an increased affinity of RNAP to DksA while the other half is independent of DksA. Stringent-like response activating mutations might be the most diverse class of mutations reducing susceptibility to antibiotics.
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| 18. |
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| 19. |
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| 20. |
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| 21. |
- Garcaa-Fernandez, Angel F., et al.
(author)
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Gaussian implementation of the multi-Bernoulli mixture filter
- 2019
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In: FUSION 2019 - 22nd International Conference on Information Fusion.
-
Conference paper (peer-reviewed)abstract
- This paper presents the Gaussian implementation of the multi-Bernoulli mixture (MBM) filter. The MBM filter provides the filtering (multi-target) density for the standard dynamic and radar measurement models when the birth model is multi-Bernoulli or multi-Bernoulli mixture. Under linear/Gaussian models, the single target densities of the MBM mixture admit Gaussian closed-form expressions. Murty's algorithm is used to select the global hypotheses with highest weights. The MBM filter is compared with other algorithms in the literature via numerical simulations.
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| 22. |
- Garcia, Angel, 1984, et al.
(author)
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Poisson Multi-Bernoulli Mixture Filter: Direct Derivation and Implementation
- 2018
-
In: IEEE Transactions on Aerospace and Electronic Systems. - 1557-9603 .- 0018-9251. ; 54:4, s. 1883-1901
-
Journal article (peer-reviewed)abstract
- We provide a derivation of the Poisson multi-Bernoulli mixture (PMBM) filter for multitarget tracking with the standard point target measurements without using probability generating functionals or functional derivatives. We also establish the connection with the δ-generalized labeled multi-Bernoulli (δ -GLMB) filter, showing that a δ-GLMB density represents a multi-Bernoulli mixture with labeled targets so it can be seen as a special case of PMBM. In addition, we propose an implementation for linear/Gaussian dynamic and measurement models and how to efficiently obtain typical estimators in the literature from the PMBM. The PMBM filter is shown to outperform other filters in the literature in a challenging scenario.
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| 23. |
- Garcia, Angel, 1984, et al.
(author)
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Trajectory multi-Bernoulli filters for multi-target tracking based on sets of trajectories
- 2020
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In: Proceedings of 2020 23rd International Conference on Information Fusion, FUSION 2020. ; , s. 313-320
-
Conference paper (peer-reviewed)abstract
- This paper presents two multi-Bernoulli filters on sets of trajectories for multiple target tracking. The first filter provides a multi-Bernoulli approximation of the posterior density over the set of alive trajectories at the current time step. The second filter provides a multi-Bernoulli approximation of the posterior density over the set of all trajectories (alive and dead) up to the current time. We also explain the Gaussian implementation of the filters and compare them with other multiple target tracking algorithms in a simulated scenario.
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| 24. |
- Garcia, Angel, 1984, et al.
(author)
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Trajectory Poisson Multi-Bernoulli Filters
- 2020
-
In: IEEE Transactions on Signal Processing. - 1941-0476 .- 1053-587X. ; 68, s. 4933-4945
-
Journal article (peer-reviewed)abstract
- This paper presents two trajectory Poisson multi-Bernoulli (TPMB) filters for multi-target tracking: one to estimate the set of alive trajectories at each time step and another to estimate the set of all trajectories, which includes alive and dead trajectories, at each time step. The filters are based on propagating a Poisson multi-Bernoulli (PMB) density on the corresponding set of trajectories through the filtering recursion. After the update step, the posterior is a PMB mixture (PMBM) so, in order to obtain a PMB density, a Kullback-Leibler divergence minimisation on an augmented space is performed. The developed filters are computationally lighter alternatives to the trajectory PMBM filters, which provide the closed-form recursion for sets of trajectories with Poisson birth model, and are shown to outperform previous multi-target tracking algorithms.
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| 25. |
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| 26. |
- Gillberg, A., et al.
(author)
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A population-based audit of the clinical use of faecal occult blood testing in primary care for colorectal cancer
- 2012
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In: Colorectal Disease. - : Wiley. - 1462-8910 .- 1463-1318. ; 14:9, s. e539-e546
-
Journal article (peer-reviewed)abstract
- Aim Symptoms related to colorectal cancer (CRC) are common. We investigated the value of the faecal occult blood test (FOBT), when administered in primary care, in the diagnosis of CRC. Method All patients who underwent a FOBT (Hemoccult II) at 20 public primary care centres in Sormland County, Sweden, during 2000-2005, were included (n = 9048). Linkage to the Swedish Cancer Registry identified all cases of CRC. Symptoms recorded at the time of the FOBT were retrieved from the patient records. The outcome from the FOBT to diagnosis and subsequent survival was compared between patients who were FOBT negative and patients who were FOBT positive. Results One-hundred and sixty-one patients were diagnosed with CRC within 2 years after undergoing a FOBT in primary care. These comprised 18% of all 917 patients diagnosed with CRC in the county during the study period. In 41 (25.4%) of the 161 patients the test was negative. Symptoms related to CRC were documented for 158 (98%) patients at the time the FOBT was administered. The median investigation time from the FOBT test to the diagnosis of CRC was 91 days: 80 days for FOBT-positive patients and 188 days for FOBT-negative patients (P < 0.001). This difference was signficant independent of age, sex and site of tumour. The hazard ratio for FOBT negativity, 3 years after the FOBT, when adjusted for age and sex, was 1.47 (95% CI, 0.812.68). Conclusion Despite having suggestive symptoms, 41 (4.5%) of 917 CRC patients had a negative FOBT result in primary care. This was associated with diagnostic delay and, potentially, a worse outcome.
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| 27. |
- Granström, Karl, 1981, et al.
(author)
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Spatiotemporal Constraints for Sets of Trajectories with Applications to PMBM Densities
- 2020
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In: Proceedings of 2020 23rd International Conference on Information Fusion, FUSION 2020. ; , s. 343-350
-
Conference paper (peer-reviewed)abstract
- In this paper we introduce spatiotemporal constraints for trajectories, i.e., restrictions that the trajectory must be in some part of the state space (spatial constraint) at some point in time (temporal constraint). Spatiotemporal contraints on trajectories can be used to answer a range of important questions, including, e.g., “where did the person that were in area A at time t, go afterwards?”. We discuss how multiple constraints can be combined into sets of constraints, and we then apply sets of constraints to set of trajectories densities, specifically Poisson Multi-Bernoulli Mixture (PMBM) densities. For Poisson target birth, the exact posterior density is PMBM for both point targets and extended targets. In the paper we show that if the unconstrained set of trajectories density is PMBM, then the constrained density is also PMBM. Examples of constrained trajectory densities motivate and illustrate the key results.
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| 28. |
- Gunnarsson, H, et al.
(author)
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Heterogeneity of colon cancer patients reported as emergencies
- 2014
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In: World Journal of Surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 38:7, s. 1819-1826
-
Journal article (peer-reviewed)abstract
- BACKGROUND:Up to one-fourth of all colon cancer patients are reported as emergencies, and the aim of the present study was to scrutinize mode of presentation in this group.MATERIALS AND METHODS:All reported cases of emergency (n = 263) and randomly selected elective controls (1:2) of colon cancer in four Swedish counties 2006-2008 were eligible (n = 854). Symptoms and aspects of management were retrieved from surgery and primary care records. Outcomes were compared using Kaplan-Meier estimates and Cox regression.RESULTS:Among patients reported as emergencies, 158/263 (60 %) underwent operation within three days (acute), and 105 (40 %) after more than 3 days (subacute). In the latter group, 20/94 (21 %) had reported two symptoms, and 31/94 (33 %) had reported three or more symptoms associated with colon cancer to primary care during the last 12 months prior to surgery. In total, 46/105 (44 %) had already had an examination of the large bowel, and 52/105 (50 %) were stage IV, as opposed to 36/158 (23 %) in the acute group and 83/577 (15 %) in the elective group (p < 0.001). Mortality at 30 and 90 days was 15.2 and 35.6 % in the subacute group, 8.2 and 14.9 % in the acute group (p = 0.001), and 1.9 and 4.3 % in the elective group (p < 0.001); 5-year survival was 28.3, 40.1, and 57.8 %, respectively, in the three groups (p < 0.001). The hazard ratio, adjusted for age, sex, and stage, was 1.88 95 % confidence interval (CI) 1.5-2.4) for the acute group and 2.29 (95 % CI 1.7-3.1) for the subacute group.CONCLUSIONS:Colon cancer patients reported as emergencies but operated upon more than three days after admission had the worst outcome. Efforts to decrease the interval between admission and surgery is one important aspect of care, but wider attention must also be paid to this group of patients.
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| 29. |
- Hemminki, Kari, et al.
(author)
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Familial risks in nervous system tumours: joint Nordic study.
- 2010
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 102, s. 1786-1790
-
Journal article (peer-reviewed)abstract
- Background:Familial nervous system cancers are rare and limited data on familial aspects are available particularly on site-specific tumours.Methods:Data from five Nordic countries were used to analyse familial risks of nervous system tumours. Standardised incidence ratios (SIRs) were calculated for offspring of affected relatives compared with offspring of non-affected relatives.Results:The total number of patients with nervous system tumour was 63 307, of whom 32 347 belonged to the offspring generation. Of 851 familial patients (2.6%) in the offspring generation, 42 (4.7%) belonged to the families of a parent and at least two siblings affected. The SIR of brain tumours was 1.7 in offspring of affected parents; it was 2.0 in siblings and 9.4 in families with a parent and sibling affected. For spinal tumours, the SIRs were much higher for offspring of early onset tumours, 14.0 for offspring of affected parents and 22.7 for siblings. The SIRs for peripheral nerve tumours were 16.3 in offspring of affected parents, 27.7 in siblings and 943.9 in multiplex families.Conclusion:The results of this population-based study on medically diagnosed tumours show site-, proband- and age-specific risks for familial tumours, with implications for clinical genetic counselling and identification of the underlying genes.British Journal of Cancer advance online publication, 25 May 2010; doi:10.1038/sj.bjc.6605708 www.bjcancer.com.
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| 35. |
- Olsson, L. I., et al.
(author)
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Socioeconomic inequalities in the use of radiotherapy for rectal cancer : A nationwide study
- 2011
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 47:3, s. 347-353
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Journal article (peer-reviewed)abstract
- Preoperative radiotherapy (PRT) in rectal cancer reduces the risk of local recurrence by at least half but the influence of the socioeconomic status of patients on the use of PRT is little investigated in Europe. METHODS: Individually attained data on civil status, education and income were linked to the Swedish Rectal Cancer Registry 1995-2005 (n=16,713) and analysed by logistic regression. RESULTS: Forty-six percentage of the patients received PRT and the crude rate varied with age, gender, civil status, education and income as well as with sublocalisation, stage, type of hospital and health care region. In a multivariate analysis, all civil status groups had PRT to a lesser extent compared with married patients; odds ratio (OR) for unmarried patients was 0.67 (95% confidence interval (CI) 0.59-0.76). Patients with secondary and university education had PRT to the same extent as those with compulsory school (OR 1.04 (0.94-1.15) and 0.92 (0.81-1.06)). The use of PRT was associated with income; OR for patients with income Q1 versus Q4 was 0.76 (0.67-0.86). The inequalities by civil status and income remained unchanged also in groups with a relatively stronger indication for adjuvant radiotherapy, i.e. younger patients and in low rectal cancer. CONCLUSION: Unmarried and low-income patients are at increased risk for not receiving PRT in rectal cancer. Comorbidity may explain some differences but increased awareness of the role of non-medical variables for the use of PRT is warranted.
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| 36. |
- Olsson, L. I., et al.
(author)
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Sphincter preservation in rectal cancer is associated with patients' socioeconomic status
- 2010
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In: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 97:10, s. 1572-1581
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Journal article (peer-reviewed)abstract
- BACKGROUND: Decision making regarding the choice of surgical procedure in rectal cancer is complex. It was hypothesized that, in addition to clinical factors, several aspects of patients' socioeconomic background influence this process. METHODS: Individually attained data on civil status, education and income were linked to the Swedish Rectal Cancer Registry 1995-2005 (16 713 patients) and analysed by logistic regression. RESULTS: Anterior resection (AR) was performed in 7433 patients (44.5 per cent), abdominoperineal resection (APR) in 3808 (22.8 per cent) and Hartmann's procedure in 1704 (10.2 per cent). Unmarried patients were least likely (odds ratio (OR) 0.76, 95 per cent confidence interval (c.i.) 0.64 to 0.88) and university-educated men were most likely (OR 1.30, 1.04 to 1.62) to have an AR. Patients with the highest income were more likely to undergo AR (OR 0.80, 0.85 and 0.86 respectively for first, second and third income quartiles). Socioeconomic differences in the use of AR were smallest among the youngest patients. Unmarried patients were more likely (OR 1.21, 95 per cent c.i. 1.00 to 1.48) and university-educated patients less likely (OR 0.78, 95 per cent c.i. 0.63 to 0.98) to have an APR. CONCLUSION: The choice of surgical strategy in rectal cancer is not socioeconomically neutral. Confounding factors, such as co-morbidity or smoking, may explain some of the differences but inequality in treatment is also plausible.
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| 37. |
- Stenström, P, et al.
(author)
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Total colonic aganglionosis: multicentre study of surgical treatment and patient-reported outcomes up to adulthood.
- 2020
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In: BJS open. - 2474-9842. ; 4:5, s. 943-953
-
Journal article (peer-reviewed)abstract
- Surgery for total colonic aganglionosis (TCA) is designed to preserve continence and achieve satisfactory quality of life. This study evaluated a comprehensive group of clinical and social outcomes.An international multicentre study from eight Nordic hospitals involving examination of case records and a patient-reported questionnaire survey of all patients born with TCA between 1987 and 2006 was undertaken.Of a total of 116 patients, five (4·3 per cent) had died and 102 were traced. Over a median follow-up of 12 (range 0·3-33) years, bowel continuity was established in 75 (73·5 per cent) at a median age of 11 (0·5-156) months. Mucosectomy with a short muscular cuff and straight ileoanal anastomosis (SIAA) (29 patients) or with a J pouch (JIAA) (26) were the most common reconstructions (55 of 72, 76 per cent). Major early postoperative complications requiring surgical intervention were observed in four (6 per cent) of the 72 patients. In 57 children aged over 4 years, long-term functional bowel symptoms after reconstruction included difficulties in holding back defaecation in 22 (39 per cent), more than one faecal accident per week in nine (16 per cent), increased frequency of defaecation in 51 (89 per cent), and social restrictions due to bowel symptoms in 35 (61 per cent). Enterocolitis occurred in 35 (47 per cent) of 72 patients. Supplementary enteral and/or parenteral nutrition was required by 51 (55 per cent) of 93 patients at any time during follow-up. Of 56 responders aged 2-20 years, true low BMI for age was found in 20 (36 per cent) and 13 (23 per cent) were short for age.Reconstruction for TCA was associated with persistent bowel symptoms, and enterocolitis remained common. Multidisciplinary follow-up, including continuity of care in adulthood, might improve care standards in patients with TCA.
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| 38. |
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| 39. |
- Valadkhani, Arman, et al.
(author)
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Postoperative complications and myocardial injury in patients receiving air or oxygen. Prospective, randomised and pilot study
- 2022
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In: Acta Anaesthesiologica Scandinavica. - : WILEY. - 0001-5172 .- 1399-6576. ; 66:10, s. 1185-1192
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Journal article (peer-reviewed)abstract
- Background Supplementary oxygen is administered during anaesthesia to increase oxygen delivery and prevent hypoxia. Recent studies have questioned this routine. In this pilot study, our main aim was to investigate if 21% oxygen compared to >= 50% reduces the risk of postoperative complications and myocardial injury. Methods In this pragmatic, multicentre, single-blind study, patients undergoing vascular surgery were randomised to receive a fraction of inspired oxygen (FiO2) >= 0.50 and oxygen saturation determined by pulse oximetry (SpO(2)) >= 98% (group H) or FiO2 of 0.21 and SpO(2) > 90% (group N) oxygen perioperatively. The primary outcome was a composite outcome of major pre-defined postoperative complications assessed at 30 days. Myocardial injury was determined by serial troponin measurements. Data were analysed using generalised estimating equation, Mann-Whitney U test or chi-squared test, as appropriate. Results The 191 patients were randomised, and per-protocol principle was used for analyses. At 30-day follow-up, 43 out of 94 patients (46%) had a postoperative complication in group H and 36 out of 90 patients (40%) in group N, p = .46. New myocardial injury was seen in 27% versus 22% in Groups H and N respectively (p = .41). No differences in other outcomes were observed between the groups. Twelve patients (13%) in Group N had SpO(2) < 90%, six recovered spontaneously and six required supplemental oxygen. At 1-year follow-up, one patient in group H had died. Conclusion In this pilot study, postoperative complications were similar between the groups in patients randomised to FiO2 of 0.21 or >= 0.50 and no difference was found in the incidence of new myocardial injury. Larger, prospective adequately powered studies are needed.
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| 40. |
- von Stedingk, LV, et al.
(author)
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The human granulocytic ehrlichiosis (HGE) agent in Swedish ticks
- 1997
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In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1469-0691. ; 3:5, s. 573-574
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Journal article (peer-reviewed)
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| 41. |
- Xia, Yuxuan, 1993, et al.
(author)
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Backward simulation for sets of trajectories
- 2020
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In: Proceedings of 2020 23rd International Conference on Information Fusion, FUSION 2020.
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Conference paper (peer-reviewed)abstract
- This paper presents a solution for recovering full trajectory information, via the calculation of the posterior of the set of trajectories, from a sequence of multitarget (unlabelled) filtering densities and the multitarget dynamic model. Importantly, the proposed solution opens an avenue of trajectory estimation possibilities for multitarget filters that do not explicitly estimate trajectories. In this paper, we first derive a general multitrajectory forward-backward smoothing equation based on sets of trajectories and the random finite set framework. Then we show how to sample sets of trajectories using backward simulation when the multitarget filtering densities are multi-Bernoulli processes. The proposed approach is demonstrated in a simulation study.
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| 42. |
- Xia, Yuxuan, 1993, et al.
(author)
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Extended target Poisson multi-Bernoulli mixture trackers based on sets of trajectories
- 2019
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In: FUSION 2019 - 22nd International Conference on Information Fusion.
-
Conference paper (peer-reviewed)abstract
- The Poisson multi-Bernoulli mixture (PMBM) is a multi-target distribution for which the prediction and update are closed. By applying the random finite set (RFS) framework to multi-target tracking with sets of trajectories as the variable of interest, the PMBM trackers can efficiently estimate the set of target trajectories. This paper derives two trajectory RFS filters for extended target tracking, called extended target PMBM trackers. Compared to the extended target PMBM filter based on sets on targets, explicit track continuity between time steps is provided in the extended target PMBM trackers.
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| 43. |
- Xia, Yuxuan, 1993, et al.
(author)
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Multiple Object Trajectory Estimation Using Backward Simulation
- 2022
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In: IEEE Transactions on Signal Processing. - 1941-0476 .- 1053-587X. ; 70, s. 3249-3263
-
Journal article (peer-reviewed)abstract
- This paper presents a general solution for computing the multi-object posterior for sets of trajectories from a sequence of multi-object (unlabelled) filtering densities and a multi-object dynamic model. Importantly, the proposed solution opens an avenue of trajectory estimation possibilities for multi-object filters that do not explicitly estimate trajectories. In this paper, we first derive a general multi-trajectory backward smoothing equation based on random finite sets of trajectories. Then we show how to sample sets of trajectories using backward simulation for Poisson multi-Bernoulli filtering densities, and develop a tractable implementation based on ranked assignment. The performance of the resulting multi-trajectory particle smoothers is evaluated in a simulation study, and the results demonstrate that they have superior performance in comparison to several state-of-the-art multi-object filters and smoothers.
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| 44. |
- Xia, Yuxuan, 1993, et al.
(author)
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Multiscan implementation of the trajectory poisson multi-Bernoulli mixture filter
- 2019
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In: Journal of Advances in Information Fusion. - 1557-6418. ; 14:2, s. 213-235
-
Journal article (peer-reviewed)abstract
- The Poisson multi-Bernoulli mixture (PMBM) and the multi-Bernoulli mixture (MBM) are two multitarget distributions for which closed-form filtering recursions exist. The PMBM has a Poisson birth process, whereas the MBM has a multi-Bernoulli birth process. This paper considers a recently developed formulation of the multitarget tracking problem using a random finite set of trajectories, through which the track continuity is explicitly established. A multiscan trajectory PMBM filter and a multiscan trajectory MBM filter, with the ability to correct past data association decisions to improve current decisions, are presented. In addition, a multiscan trajectory MBM01 filter, in which the existence probabilities of all Bernoulli components are either 0 or 1, is presented. This paper proposes an efficient implementation that performs track-oriented N-scan pruning to limit computational complexity, and uses dual decomposition to solve the involved multiframe assignment problem. The performance of the presented multitarget trackers, applied with an efficient fixed-lag smoothing method, is evaluated in a simulation study.
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| 45. |
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| 46. |
- Xia, Yuxuan, 1993, et al.
(author)
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Trajectory PMB Filters for Extended Object Tracking Using Belief Propagation
- 2023
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In: IEEE Transactions on Aerospace and Electronic Systems. - 1557-9603 .- 0018-9251. ; 59:6, s. 9312-9331
-
Journal article (peer-reviewed)abstract
- In this paper, we propose a Poisson multi-Bernoulli (PMB) filter for extended object tracking (EOT), which directly estimates the set of object trajectories, using belief propagation (BP). The proposed filter propagates a PMB density on the posterior of sets of trajectories through the filtering recursions over time, where the PMB mixture (PMBM) posterior after the update step is approximated as a PMB. The efficient PMB approximation relies on several important theoretical contributions. First, we present a PMBM conjugate prior on the posterior of sets of trajectories for a generalized measurement model, in which each object generates an independent set of measurements. The PMBM density is a conjugate prior in the sense that both the prediction and the update steps preserve the PMBM form of the density. Second, we present a factor graph representation of the joint posterior of the PMBM set of trajectories and association variables for the Poisson spatial measurement model. Importantly, leveraging the PMBM conjugacy and the factor graph formulation enables an elegant treatment on undetected objects via a Poisson point process and efficient inference on sets of trajectories using BP, where the approximate marginal densities in the PMB approximation can be obtained without enumeration of different data association hypotheses. To achieve this, we present a particle-based implementation of the proposed filter, where smoothed trajectory estimates, if desired, can be obtained via single-object particle smoothing methods, and its performance for EOT with ellipsoidal shapes is evaluated in a simulation study.
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