| 1. |
- Adiels, L., et al.
(author)
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Pi0 and eta spectra from proton-antiproton annihilations at rest
- 1984
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In: Zeitschrift für Physik. C, Particles and fields. - 0170-9739. ; 21:4, s. 315-319
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Journal article (peer-reviewed)abstract
- The low-energy part of the Ï€0 spectrum associated with Mathematical expression annihilation at rest was measured in order to search for bound baryonium-like states. The upper limit for reaching such states via the emission of monochromatic Ï€0’s was found to be 8% per annihilation in the mass region of 1650 MeV. The low-energy part of the η spectrum from Mathematical expression annihilations at rest was also observed.
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| 2. |
- Adiels, L., et al.
(author)
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Search for narrow exotic states in annihilations on 4He
- 1984
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 138:1-3, s. 235-240
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Journal article (peer-reviewed)abstract
- After having found evidence for narrow exotic states in p annihilation, the production of such states on a nuclear target was studied with similar techniques. The γ spectrum associated with annihilation on 4He at rest was measured. The spectrum shows two peaks, at energies of 161.9 and 203.0 MeV, corresponding to intermediate narrow states of masses which seem to be related to states found in p annihilations. The confidence is better than 4 σ.
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| 3. |
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| 4. |
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| 5. |
- Blüm, P., et al.
(author)
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A modular NaI(Tl) detector for 20-1000 MeV photons
- 1983
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In: Nuclear Instruments and Methods in Physics Research. - : Elsevier BV. - 0167-5087. ; 213:2-3, s. 251-259
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Journal article (peer-reviewed)abstract
- A detector consisting of 54 NaI (Tl) modules is described. The detector has been optimized for the detection of 20-1000 MeV photons. An energy resolution (fwhm) of 5.5% at 130 MeV could be attained, and the stability has been better than 1% over several months.
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| 6. |
- Guigas, R., et al.
(author)
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Strong interaction effects in antiprotonic 6Li/7Li atoms
- 1984
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 137:56, s. 323-328
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Journal article (peer-reviewed)abstract
- The effects of strong interaction on the 3 –> 2 X-ray transition in antiprotonic 6Li/7Li atoms have been measured at the low energy -beam at CERN. For the shifts and widths of the levels the values [epsilon]2p = (-230 ï¿œ 72) eV, [Gamma]2p = (443 ï¿œ 210) eV, and [Gamma]3d = (0.130 ï¿œ 0.045) eV for 6Li, and [epsilon]2p = (-336 ï¿œ 60) eV, [Gamma]2p = (456 ï¿œ 190) eV, and [Gamma]3d = (0.210 ï¿œ 0.062) eV for 7Li were found. The data are compared with optical model predictions.
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| 7. |
- Richter, B., et al.
(author)
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New results in the search for narrow states in the p system below threshold
- 1983
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 126:3-4, s. 284-288
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Journal article (peer-reviewed)abstract
- The γ-ray spectrum after p annihilation at rest was measured in two independent high-statistics runs. Both spectra show narrow peaks, corresponding to masses of 1210, 1638, 1694 and 1771 MeV.
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| 8. |
- 't Hart, Leen M., et al.
(author)
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The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway
- 2013
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 62:9, s. 3275-3281
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Journal article (peer-reviewed)abstract
- The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances -cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P 8.8 x 10(-7)). rs7202877 near CTRB1/2, a known diabetes risk locus, also associated with an absolute 0.51 +/- 0.16% (5.6 +/- 1.7 mmol/mol) lower A1C response to DPP-4 inhibitor treatment in G-allele carriers, but there was no effect on GLP-1 RA treatment in type 2 diabetic patients (n = 527). Furthermore, in pancreatic tissue, we show that rs7202877 acts as expression quantitative trait locus for CTRB1 and CTRB2, encoding chymotrypsinogen, and increases fecal chymotrypsin activity in healthy carriers. Chymotrypsin is one of the most abundant digestive enzymes in the gut where it cleaves food proteins into smaller peptide fragments. Our data identify chymotrypsin in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment.
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| 9. |
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