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- Hammarqvist, F
(author)
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Can it all be done by enteral nutrition?
- 2004
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In: Current opinion in clinical nutrition and metabolic care. - : Ovid Technologies (Wolters Kluwer Health). - 1363-1950. ; 7:2, s. 183-187
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Journal article (peer-reviewed)
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- Hammarqvist, F, et al.
(author)
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Effects of growth hormone and insulin-like growth factor-1 on postoperative muscle and substrate metabolism
- 2010
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In: Journal of nutrition and metabolism. - : Hindawi Limited. - 2090-0732 .- 2090-0724. ; 2010
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Journal article (peer-reviewed)abstract
- This study explored if a combined supplementation of GH and IGF-1 had an additive effect on whole body nitrogen economy, energy, substrate and skeletal muscle metabolism following surgical trauma. Patients were randomized to controls (C;n=10), to GH (0.15 IU/kg/injection) (GH;n=7) or GH combined with IGF-1 (40 μg/kg/injection) subcutaneously twice a day (GH-IGF-1;n=9) together with standardized parenteral nutrition. Muscle amino acids, glutathione and the ribosomal pattern reflecting protein synthesis, and nitrogen balance were measured. GH- and GH-IGF-1 groups showed lower urea and higher plasma glucose concentrations. Energy expenditure increased in the GH-group. GH-IGF-1 prevented a decrease in muscle polyribosomes indicating a preserved muscle protein synthesis. In the GH group unaltered BCAA and AAA levels were seen in muscle indicating an unchanged protein breakdown, while the other groups showed increased muscle concentrations postoperatively. Without statistically difference GH marginally improved the nitrogen balance, in terms of higher values, and growth factors improved the nitrogen balance when the shift in urea was taken into account. To conclude, growth factors influences urea metabolism, protein degradation and protein synthesis. There was no clearcut additional effect when combining GH and IGF-1 but the study was probably underpowered to outrule this and effects on nitrogen balance.
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- Hammarqvist, F, et al.
(author)
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In memory of Erik Vinnars
- 2006
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In: CLINICAL NUTRITION. - : Elsevier BV. - 0261-5614. ; 25:6, s. 869-870
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Journal article (other academic/artistic)
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- Soop, M., et al.
(author)
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Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3 days after surgery
- 2004
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In: Clin Nutr. - Edinburgh, United Kingdom : Elsevier BV. - 0261-5614 .- 1532-1983. ; 23:4, s. 733-41
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Journal article (peer-reviewed)abstract
- BACKGROUND & AIMS: Postoperative metabolism is characterised by insulin resistance and a negative whole-body nitrogen balance. Preoperative carbohydrate treatment reduces insulin resistance in the first day after surgery. We hypothesised that preoperative oral carbohydrate treatment attenuates insulin resistance and improves whole-body nitrogen balance 3 days after surgery. METHODS: Fourteen patients undergoing total hip replacement were double-blindly randomised to preoperative oral carbohydrate treatment (12.5%, 800 + 400 ml, n = 8) or placebo (n = 6). Glucose kinetics (6,6-D2-glucose), substrate utilisation (indirect calorimetry) and insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) were measured preoperatively and on the third day after surgery. Nitrogen losses were monitored for 3 days after surgery. Values are mean (SEM). Analysis of variance (ANOVA) statistics were used. RESULTS: Endogenous glucose release during insulin infusion increased after surgery in the placebo group. Preoperative carbohydrate treatment, as compared to placebo, significantly attenuated postoperative endogenous glucose release (0.69 (0.07) vs. 1.21 (0.13)mg kg(-1) x min(-1), P < 0.01), while whole-body glucose disposal and nitrogen balance were similar between groups. CONCLUSIONS: While insulin resistance in the first day after surgery has previously been characterised by reduced glucose disposal, enhanced endogenous glucose release was the main component of postoperative insulin resistance on the third postoperative day. Preoperative carbohydrate treatment attenuated endogenous glucose release on the third postoperative day.
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- Stromberg, J, et al.
(author)
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Cholecystectomy in Patients with Liver Cirrhosis
- 2015
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In: Gastroenterology research and practice. - : Hindawi Limited. - 1687-6121 .- 1687-630X. ; 2015, s. 783823-
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Journal article (peer-reviewed)abstract
- Background. The aim of this population-based study was to describe characteristics of patients with liver cirrhosis undergoing cholecystectomy and evaluate the risk for perioperative and postoperative complications during the 30-day postoperative period.Method. All laparoscopic and open cholecystectomy procedures registered between 2006 and 2011 in the Swedish Registry for Gallstone Surgery and ERCP (GallRiks) were included. Patients with liver cirrhosis were identified by linking data to the Swedish National Patient Registry (NPR).Results. Of 62,488 patients undergoing cholecystectomy, 77 (0.12%) had cirrhosis, of which 29 patients (37.7%) had decompensated cirrhosis. Patients with cirrhosis were older and had more often gallstone complications at the time for surgery. Postoperative complications were registered in 13 (16.9%) patients with liver cirrhosis and in 5,738 (9.2%) patients in the noncirrhotic group(P<0.05). Univariable analysis showed that patients with liver cirrhosis are more likely to receive postoperative blood transfusion (OR = 4.4, CI 1.08–18.0,P<0.05) and antibiotic treatment >1 day (OR = 2.3, CI 1.11–4.84,P<0.05) than noncirrhotic patients.Conclusion. Patients with cirrhosis undergoing cholecystectomy have a higher incidence of postoperative complications than patients without cirrhosis. However, cholecystectomy is safe and if presented with adequate indication, surgery should not be delayed due to fears of surgical complications.
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- Wernerman, J, et al.
(author)
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Glutathione status in critically-ill patients: possibility of modulation by antioxidants
- 1999
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In: The Proceedings of the Nutrition Society. - : Cambridge University Press (CUP). - 0029-6651. ; 58:3, s. 677-680
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Journal article (peer-reviewed)abstract
- Muscle tissue serves as a protein reservoir which is mobilized to meet the specific metabolic needs associated with various catabolic conditions in human subjects, such as trauma and critical illness. Glutathione is one of the most abundant short-chain peptides and a major source of non-protein thiol in the body, and tissue glutathione concentration is related to its oxidative capacity. Skeletal muscle is relatively unique with respect to a variety of metabolic properties, such as oxidative potential, patterns of amino acid utilization, and antioxidant enzyme activity. The glutathione concentration is not influenced by food intake, or by food deprivation. Moreover, there is no diurnal variation on muscle glutathione levels. Following elective surgery the muscle concentration of GSH (the reduced form) decreases by 40 % 24 h post-operatively, while the concentration of GSSG (the oxidized form) remains unaltered. During critical illness a similar decrease in the GSH concentration is seen, but in addition a change in the redox status indicative of an elevated GSSG level occurs. Furthermore, correlations between the concentrations of glutamine as well as glutamate and GSH exist in these patients. From available evidence accumulated it is clear that glutathione plays a pivotal role in the maintenance of the intracellular redox status, the antioxidant vitamin levels, and the antioxidant enzyme functions under various metabolic conditions. The effectiveness of glutathione protection in the individual tissue depends on the tissue concentration of glutathione as well as the capacity of the tissue to import GSH and to export GSSG. The mechanisms by which catabolism regulates tissue glutathione levels and the enzyme activities associated with the γ-glutamyl cycle are not completely understood and further studies need to be conducted.
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- Wernerman, J, et al.
(author)
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Modulation of endogenous glutathione availability
- 1999
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In: Current opinion in clinical nutrition and metabolic care. - : Ovid Technologies (Wolters Kluwer Health). - 1363-1950. ; 2:6, s. 487-92
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Journal article (peer-reviewed)
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- Wernerman, J, et al.
(author)
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Protein metabolism in critical illness
- 1996
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In: Bailliere's clinical endocrinology and metabolism. - 0950-351X. ; 10:4, s. 603-615
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Journal article (peer-reviewed)
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- Wernerman, J, et al.
(author)
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Tissue-specific effects of growth hormone on protein metabolism
- 1998
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In: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. - : Elsevier BV. - 1096-6374. ; 88 Suppl B, s. 111-113
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Journal article (peer-reviewed)
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