| 1. |
- Golman, Klaes, et al.
(author)
-
13C-angiography.
- 2002
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In: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Journal article (peer-reviewed)
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| 2. |
- Bjalkebring, Par, et al.
(author)
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Helping Out or Helping Yourself? : Volunteering and Life Satisfaction Across the Retirement Transition
- 2021
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In: Psychology and Aging. - : AMER PSYCHOLOGICAL ASSOC. - 0882-7974 .- 1939-1498. ; 36:1, s. 119-130
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Journal article (peer-reviewed)abstract
- It has been suggested that volunteering leads to increases in well-being, particularly in older and retiring adults, and that volunteering could be used as a public health intervention to increase well-being. However, the causal relationship has been questioned. We investigated the association between voluntary work and life satisfaction in a bivariate dual-change score model, using 4 years of longitudinal data from 1,123 participants from the Health, Aging and Retirement Transitions in Sweden (HEARTS) study. Both the frequency of volunteering and the level of life satisfaction increased across the retirement transition. However, baseline life satisfaction and volunteering were only marginally associated. Further, the coupling parameters suggest that higher levels of volunteering were followed by decreases in life satisfaction and that higher levels of life satisfaction were followed by increases in volunteering. These findings suggest that increasing levels of volunteering might not be a fruitful strategy for improving life satisfaction for all older adults-if people engage too much in voluntary work, it might even be detrimental for their life satisfaction. More research is needed to better understand when and for whom increased levels of volunteering might have positive effects on life satisfaction.
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| 3. |
- Bjälkebring, Pär, 1984, et al.
(author)
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Helping Out or Helping Yourself? Volunteering and Life Satisfaction Across the Retirement Transition : Supplemental Material
- 2021
-
In: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 36:1, s. 119-130
-
Journal article (peer-reviewed)abstract
- © 2020 American Psychological Association. It has been suggested that volunteering leads to increases in well-being, particularly in older and retiring adults, and that volunteering could be used as a public health intervention to increase well-being. However, the causal relationship has been questioned. We investigated the association between voluntary work and life satisfaction in a bivariate dual-change score model, using 4 years of longitudinal data from 1,123 participants from the Health, Aging and Retirement Transitions in Sweden (HEARTS) study. Both the frequency of volunteering and the level of life satisfaction increased across the retirement transition. However, baseline life satisfaction and volunteering were only marginally associated. Further, the coupling parameters suggest that higher levels of volunteering were followed by decreases in life satisfaction and that higher levels of life satisfaction were followed by increases in volunteering. These findings suggest that increasing levels of volunteering might not be a fruitful strategy for improving life satisfaction for all older adults-if people engage too much in voluntary work, it might even be detrimental for their life satisfaction. More research is needed to better understand when and for whom increased levels of volunteering might have positive effects on life satisfaction.
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| 4. |
-
Böter och fredsköp : Jämtlands och Härjedalens saköreslängder 1601–1645
- 2016
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In: Historisk tidsskrift. - Östersund : Landsarkivet i Östersund. - 0018-263X .- 1504-2944.
-
Editorial collection (other academic/artistic)abstract
- This is an edition, with commentary, of a series of judicial accounts for the provinces of Jämtland and Härjedalen, dating from 1601 to 1645. Jämtland and Härjedalen are today parts of Sweden, but belonged to Norway until 1645. During the period in question, Norway was part of the dualistic unitary state of Denmark-Norway. The present accounts were made by the bailiffs serving in Jämtland and Härjedalen. They report fines collected by the bailiffs and the misdeeds people were fined for. The bailiffs were subordinate to the feudal lord residing in Trondheim, who had the right to one sixth of the fines collected. The rest of the fines went, together with the accounts and other revenues and records as well, to the treasury of King Kristian IV in Copenhagen. Today all these records are kept in the national archives of Norway and Sweden. In the introduction, Per Sörlin describes and discusses the contents of the judicial accounts, the criminality they reflect, the social setting, the administration in Jämtland and Härjedalen, along with other subjects. In the main part of the edition all text of the judicial accounts is transcribed. Two lists of so-called ‘fredsköp’ (purchases of peace), i.e. fines for eluding outlawry after the 1611–1613 war against Sweden, are included as appendices. These fines were paid by farmers of Jämtland who were punished by the Danish King for disloyalty during the war. Also included in the edition are an investigation of the feudal lords and bailiffs in charge in Jämtland and Härjedalen 1601–45, indices of place-names and officials, and a word list.
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| 5. |
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| 6. |
- Frankel, Rebecca, et al.
(author)
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Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
- 2019
-
In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 2:1
-
Journal article (peer-reviewed)abstract
- Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo using cerebrospinal fluid (CSF). We investigated the aggregation mechanism of Aβ42 in human CSF through kinetic experiments at several Aβ42 monomer concentrations (0.8–10 µM). The data were subjected to global kinetic analysis and found consistent with an aggregation mechanism involving secondary nucleation of monomers on the fibril surface. A mechanism only including primary nucleation was ruled out. We find that the aggregation process is composed of the same microscopic steps in CSF as in pure buffer, but the rate constant of secondary nucleation is decreased. Most importantly, the autocatalytic amplification of aggregate number through catalysis on the fibril surface is prevalent also in CSF.
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| 7. |
- Giang, Kok Wai, 1984, et al.
(author)
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Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease
- 2018
-
In: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 49:5, s. 1155-1162
-
Journal article (peer-reviewed)abstract
- Background and Purpose-The risk of ischemic stroke is increased in patients with congenital heart disease (CHD); however, data on the risk of hemorrhagic stroke, including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), are lacking. Methods-The Swedish Patient Register was used to identify all patients who were born with a diagnosis of CHD between 1970 and 1993. Each patient was compared with 10 randomly selected controls from the general population, matched for age, sex, and county. Follow-up data were collected until December 2011 for both cases and controls. Results-Of 21 982 patients with CHD, 70 developed ICH and 57 developed SAH up to the age of 42 years. CHD patients had more than an 8x higher risk (incidence rate ratio, 8.23; 95% confidence interval, 6-11.2) of developing ICH and almost an 8x higher risk of developing SAH (incidence rate ratio, 7.64; 95% confidence interval, 5.41-10.7) compared with controls. The absolute risk of ICH and SAH was low, with incidence rates of 1.18 and 0.96 cases per 10 000 person-years, respectively. Patients with severe nonconotruncal defects (incidence rate ratio, 16.5; 95% confidence interval, 5.63-51.2) or coarctation of the aorta (incidence rate ratio, 17.3; 95% confidence interval, 6.63-51.8) had the highest relative risk of developing hemorrhagic stroke, with incidence rates of 3.22 and 2.79 cases per 10 000 person-years, respectively. Conclusions-The relative risk of hemorrhagic stroke among children and young adults with CHD was almost 8x higher than that of matched controls from the general population, although the absolute risk was low. The highest risk of ICH and SAH occurred in patients with severe nonconotruncal defects and coarctation of the aorta.
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| 8. |
- Golman, Klaes, et al.
(author)
-
Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.
- 2008
-
In: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 59:5, s. 1005-1013
-
Journal article (peer-reviewed)abstract
- Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-(13)C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008. (c) 2008 Wiley-Liss, Inc.
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| 9. |
-
Gårdar och arrenden : Jämtlands och Härjedalens bygsellängder 1601-1645
- 2023
-
Editorial collection (peer-reviewed)abstract
- Accounts of Lease Entrance Fees for Jämtland and Härjedalen 1601–1645. Edited by Georg Hansson and Olof Holm. With an index of place-names by Karl Göran Eriksson.This is an edition, with commentary, of a series of accounts of lease entrance fees for the provinces of Jämtland and Härjedalen, dating from 1601 to 1645. Jämtland and Härjedalen are today parts of Sweden, but belonged to Norway until 1645. During the period in question, Norway was part of the Danish-Norwegian state.The present accounts were made by the bailiffs serving in Jämtland and Härjedalen. They report an entrance fee called bygsel collected by the bailiffs when they let out crown land and so-called avradsland, i.e. divided parts of the common land, on lease to individuals. The quantity of crown land in Jämtland dramatically increased from about 4% to 69% of all land after the Kalmar War of 1611–13, when most of the farmers in this province lost their land to the Danish-Norwegian King Kristian IV. The bailiffs were subordinate to the feudal lord residing in Trondheim, who had the right to a share of the entrance fees collected. The rest of the entrance fees went, together with the accounts and other revenues and records as well, to the King’s treasury in Copenhagen. Today all these records are kept in the national archives of Sweden and Norway.In the introduction, Olof Holm describes and discusses the contents of the accounts, the lease agreements they deal with, the conditions for the leaseholders, the vast growth of crown land in Jämtland during the period, along with other subjects. In the main part of the edition all text of the bygsel accounts is transcribed. Two appendices are included: 1) excerpts from preserved letters describing leasehold agreements from the period, and 2) testimonies concerning the bailiffs’ collecting of bygsel fees. The book ends with indices of place-names and officials, and a word list.
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| 10. |
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| 11. |
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| 12. |
- Hansson, Isabelle, 1988, et al.
(author)
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The Role of Personality in Retirement Adjustment: Longitudinal Evidence for the Effects on Life Satisfaction
- 2020
-
In: Journal of personality. - : Wiley. - 0022-3506 .- 1467-6494. ; 88:4, s. 642-658
-
Journal article (peer-reviewed)abstract
- Objective: Research on retirement suggests that personality can influence the adjustment process, but the mechanisms involved remain still largely unknown. In the present study, we investigate direct and indirect associations between the Big Five personality traits and life satisfaction over the retirement transition. Indirect effects were evaluated through the role of personality for levels and changes in self‐esteem, autonomy, social support, self‐rated physical health, self‐rated cognitive ability, and financial satisfaction. Method: Our sample consisted of 796 older adults (age 60–66) and four annual measurement waves from the longitudinal population‐based HEalth, Ageing, and Retirement Transitions in Sweden (HEARTS) study, including individuals retiring during the study period. Results: Results from multivariate latent growth curve analysis revealed multiple indirect associations between personality and life satisfaction. Extraversion, Agreeableness, and Conscientiousness were positively related to life satisfaction through higher levels of self‐esteem, autonomy, and social support. Neuroticism was negatively associated with life satisfaction through lower levels of self‐esteem and lower levels and negative changes in autonomy and social support. Conclusions: Our findings suggest that retirees with higher levels of Neuroticism are more vulnerable in the transition process and they are also more likely to experience adjustment problems resulting from negative changes in key resources.
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| 13. |
- Hansson, Isabelle, 1988, et al.
(author)
-
The Role of Personality in Retirement Adjustment: Mediating Effects of Self-Esteem, Autonomy, and Social Support
- 2018
-
In: GSA Annual Scientific Meeting, Boston, Massachusetts, USA, November 14-18, 2018.
-
Conference paper (other academic/artistic)
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| 14. |
- Hedén Ståhl, Christina, 1972, et al.
(author)
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High-normal blood pressure and long-term risk of type 2 diabetes: 35-year prospective population based cohort study of men
- 2012
-
In: BMC cardiovascular disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 12:1
-
Journal article (peer-reviewed)abstract
- ABSTRACT: BACKGROUND: The link between type 2 diabetes and hypertension is well established and the conditions often coexist. High normal blood pressure, defined by WHO-ISH as systolic blood pressure (SBP) 130--139 mm Hg or diastolic blood pressure (DBP) 85--89 mm Hg, has been found to be an independent predictor for type 2 diabetes in studies, although with relatively limited follow-up periods of approximately 10 years. The aim of this study was to investigate whether hypertension, including mildly elevated blood pressure within the normal range, predicted subsequent development of type 2 diabetes in men over an extended follow-up of 35 years. METHODS: Data were derived from the Gothenburg Primary Prevention Study where a random sample of 7 494 men aged 47--55 years underwent a baseline screening investigation in the period 1970--1973. A total of 7 333 men were free from previous history of diabetes at baseline. During a 35-year follow-up diabetes was identified through the Swedish hospital discharge and death registries. The cumulative risk of diabetes adjusted for age and competing risk of death was calculated. Using Cox proportional hazard models we calculated the multiple adjusted hazard ratios (HR) (95% confidence interval (CI)) for diabetes at different blood pressure levels. RESULTS: During a 35-year follow-up, 956 men (13%) were identified with diabetes. The 35-year cumulative risk of diabetes after adjusting for age and competing risk of death in men with SBP levels <130 mm Hg, 130--139 mm Hg, 140--159 mm Hg and >=160 mm Hg were 19%, 30%, 31% and 49%, respectively. The HR for diabetes adjusted for age, body mass index (BMI), cholesterol, antihypertensive treatment, smoking, physical activity and occupation were 1.43 (95% CI 1.12-1.84), 1.43 (95% CI 1.14-1.79) and 1.95 (95% CI 1.55-2.46) for men with SBP 130--139 mm Hg, 140--159 mm Hg, and >= 160 mm Hg, respectively (reference; SBP<130 mm Hg). CONCLUSION: In this population, at mid-life, even high-normal SBP levels were shown to be a significant predictor of type 2 diabetes, independently of BMI and other conventional type 2 diabetes risk factors over an extended follow-up.
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| 15. |
- Hedén Ståhl, Christina, 1972, et al.
(author)
-
Incidence of Type 2 diabetes among occupational classes in Sweden: a 35-year follow-up cohort study in middle-aged men
- 2014
-
In: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 31:6, s. 674-680
-
Journal article (peer-reviewed)abstract
- AimsTo assess if low occupational class was an independent predictor of Type 2 diabetes in men in Sweden over a 35-year follow-up, after adjustment for both conventional risk factors and psychological stress. MethodsA random population-based sample of 6874 men aged 47-56 years without a history of diabetes was divided into five occupational classes and the men were followed from 1970 to 2008. Diabetes cases were identified through the Swedish inpatient and death registers. Subdistribution hazard ratios (SHRs) and 95% CIs from competing risk regressions, cumulative incidence and conditional probabilities were calculated, after accounting for the risk of death attributed to other causes. ResultsA total of 907 (13%) men with diabetes were identified over 35 years with a median follow-up of 27.9 years. The cumulative incidence of diabetes, when taking into account death as a competing event, was 11% in high officials, 12% in intermediate non-manual employees, 14% in assistant non-manual employees, 14% in skilled workers, and 16% in unskilled and semi-skilled workers. Men with unskilled and semi-skilled manual occupations had a significantly higher risk of diabetes than high officials (reference) after adjustment for age, BMI, hypertension, smoking and physical activity (SHR 1.39, 95% CI 1.08-1.78). Additional adjustment for self-reported psychological stress did not attenuate the results. ConclusionsA low occupational class suggests a greater risk of Type 2 diabetes, independently of conventional risk factors and psychological stress. Studies with a follow-up of 15 years have shown that Type 2 diabetes disproportionately affects people with a lower socio-economic status. With the world's aging population, it is important to determine if risk factors persist into older age groups. In contrast to many other studies, we adjusted the analysis, not only for conventional risk factors, but also for psychological stress and competing risk of death. The present study shows that low occupational class at mid-life remains an independent predictor for Type 2 diabetes after a 35-year follow-up.
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| 16. |
- Henning, Georg, et al.
(author)
-
Do neuroticism and conscientiousness interact with health conditions in predicting 4-year changes in self-rated health among Swedish older adults?
- 2021
-
In: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 36:6, s. 730-743
-
Journal article (peer-reviewed)abstract
- Health conditions such as higher disease burden, pain, or lower functional health are associated with poorer self-rated health (SRH) in older age. Poorer SRH, in turn, is a predictor of morbidity and mortality. Personality traits are associated with SRH as well, but little is known about the interaction of personality and health conditions. In the present preregistered analyses, we used five annual waves of the Health, Aging and Retirement Transitions in Sweden (HEARTS) study (N = 5,823, M age = 63.09, SD = 2.01) to investigate the associations of personality (neuroticism and conscientiousness) and physical health indices (disease burden, pain, and functional limitations) with levels and change in SRH. In addition, we tested Personality × Health interaction effects. We found that higher neuroticism and lower conscientiousness were related to lower levels of SRH, but not to change in SRH after controlling for the health indices. Personality did not moderate the effect of health indices on levels and change in SRH. Exploratory analyses showed that high scores of neuroticism may augment the association of increased pain and functional limitations with declines in SRH. Additional studies with other samples are needed to test if this result can be replicated. Taken together, our findings provide only weak evidence for interaction effects of personality and physical health factors on SRH. More research is needed to understand the interplay of physical and psychological factors in shaping individual SRH. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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| 17. |
- Henning, Georg, 1989, et al.
(author)
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Preretirement Work Motivation and Subsequent Retirement Adjustment: A Self-Determination Theory Perspective
- 2019
-
In: Work, Aging and Retirement. - : Oxford University Press (OUP). - 2054-4642 .- 2054-4650.
-
Journal article (peer-reviewed)abstract
- Research grounded in self-determination theory confirms the importance of different types of work motivation for well-being and job performance. Less is known about the role of work motivation at the end of one’s working life and its association with adjustment to retirement. We investigated the association between preretirement work motivation and retirement adjustment in a subsample of the Health, Aging and Retirement Transitions in Sweden (HEARTS) study. We included participants (n = 572) who retired between two annual waves in this longitudinal study. Retirement adjustment was operationalized as change between waves in satisfaction of the three basic psychological needs (autonomy, competence, and relatedness). The association between preretirement work motivation and retirement adjustment varied depending on the subdimension of motivation (intrinsic, identified, introjected, external, or amotivation), type of transition (full vs. partial), and the particular need (autonomy, competence, and relatedness). In line with our expectations, low intrinsic work motivation was associated with gains in autonomy satisfaction for full-time retirees, which may be interpreted as a relief from dissatisfying jobs. Among those who continued to work, high intrinsic motivation was related to increases in relatedness satisfaction, that is, retirees who were intrinsically motivated for their work seem to benefit from continuing to work in retirement. In contrast to our expectations, amotivation before retirement was associated with gains in relatedness satisfaction for those continuing to work. Our results highlight the complexity of retirement and the need to study postretirement adjustment as a multifaceted and multidirectional process.
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| 18. |
- Henning, Georg, 1989, et al.
(author)
-
The role of personality for subjective well-being in the retirement transition - Comparing variable- and person-oriented models
- 2017
-
In: Personality and Individual Differences. - : Elsevier BV. - 0191-8869. ; 116, s. 385-392
-
Journal article (peer-reviewed)abstract
- In this study we investigated the role of personality for wellbeing in the retirement transition. In a sample of Swedish older adults (N = 2.797) around retirement age (60-66), included in the Health, Aging and Retirement Transitions in Sweden(HEARTS) study, we tested if personality types and/or traits moderated the effect of retirement on change in subjective well-being across one year. We identified four personality types in a latent profile analysis. Using latent change score models, we found that those who retired between assessments showed stronger increases in subjective well-being compared to those not retiring. For one group with low openness, agreeableness, extraversion and conscientiousness, but high neuroticism, retirement was associated with a decrease in well-being. When only personality traits were included, we found a moderating effect of agreeableness so that high scores on agreeableness enhanced the increases in well-being after retirement. The results are compared and discussed in the light of research on personality and retirement. (C) 2017 Elsevier Ltd. All rights reserved.
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| 19. |
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| 20. |
- Kamal, Nadia, et al.
(author)
-
The mosaic oat genome gives insights into a uniquely healthy cereal crop
- 2022
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 606:7912, s. 113-119
-
Journal article (peer-reviewed)abstract
- Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid (Avena insularis, CCDD, 2n = 4x = 28) progenitors. We reveal the mosaic structure of the oat genome, trace large-scale genomic reorganizations in the polyploidization history of oat and illustrate a breeding barrier associated with the genome architecture of oat. We showcase detailed analyses of gene families implicated in human health and nutrition, which adds to the evidence supporting oat safety in gluten-free diets, and we perform mapping-by-sequencing of an agronomic trait related to water-use efficiency. This resource for the Avena genus will help to leverage knowledge from other cereal genomes, improve understanding of basic oat biology and accelerate genomics-assisted breeding and reanalysis of quantitative trait studies.
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| 21. |
- Lindwall, Magnus, 1975, et al.
(author)
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Psychological health in the retirement transition: Rationale and first findings in the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study
- 2017
-
In: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 8
-
Journal article (peer-reviewed)abstract
- © 2017 Lindwall, Berg, Bjälkebring, Buratti, Hansson, Hassing, Henning, Kivi, König, Thorvaldsson and Johansson. From an aging research and life-course perspective, the transition to retirement marks a significant life-event and provides a unique opportunity to study psychological health and coping during a period of substantial change in everyday life. The aim of the present paper is to: (a) outline the rationale of the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study, (b) describe the study sample, and (c) to present some initial results from the two first waves regarding the association between retirement status and psychological health. The HEARTS study is designed to annually study psychological health in the years before and following retirement, and to examine change and stability patterns related to the retirement event. Among a representative Swedish population-based sample of 14,990 individuals aged 60-66 years, 5,913 completed the baseline questionnaire in 2015. The majority of the participants (69%) completed a web-based survey, and the rest (31%) completed a paper version. The baseline HEARTS sample represents the general population well in terms of gender and age, but is more highly educated. Cross-sectional findings from the first wave showed that retired individuals demonstrated better psychological health compared to those who were still working. Longitudinal results from the first and second waves showed that individuals who retired between waves showed more positive changes in psychological health compared with those still working or previously retired.
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| 22. |
- Linse, Sara, et al.
(author)
-
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
- 2020
-
In: Nature Structural and Molecular Biology. - : Springer Science and Business Media LLC. - 1545-9993 .- 1545-9985. ; 27:12, s. 1125-1133
-
Journal article (peer-reviewed)abstract
- The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for the past 20 years. Failures of clinical trials investigating Aβ-targeted therapies have been interpreted as evidence against this hypothesis, irrespective of the characteristics and mechanisms of action of the therapeutic agents, which are highly challenging to assess. Here, we combine kinetic analyses with quantitative binding measurements to address the mechanism of action of four clinical stage anti-Aβ antibodies, aducanumab, gantenerumab, bapineuzumab and solanezumab. We quantify the influence of these antibodies on the aggregation kinetics and on the production of oligomeric aggregates and link these effects to the affinity and stoichiometry of each antibody for monomeric and fibrillar forms of Aβ. Our results reveal that, uniquely among these four antibodies, aducanumab dramatically reduces the flux of Aβ oligomers.
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| 23. |
- Magnusson, Peter, et al.
(author)
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Passive catheter tracking during interventional MRI using hyperpolarized 13C.
- 2007
-
In: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 57:6, s. 1140-1147
-
Journal article (peer-reviewed)abstract
- nterventional procedures in MRI can be performed preclinically using active or passive catheter-tracking methods. A novel passive nonproton technique is suggested that uses a catheter filled with a hyperpolarized C-13 contrast agent. A prototype three-lumen catheter was built with two closed lumens containing a flowing hyperpolarized C-13 contrast agent. Entire-length C-13 catheter projection visualization could be performed in vivo with a catheter SNR of similar to 80, one dual projection frame per similar to 700 ms, and an in-plane resolution of 2 x 2 mm(2) while traveling through the aorta of a pig. The traveling path of the C-13 catheter was visualized after back-projection catheter reconstruction and after image fusion with an anatomical offline proton road map. Catheter length visualization was aided by an oblique planar visualization mode. The high catheter signal demonstrated, together with the entire catheter length visualization and high surrounding soft-tissue contrast, warrants further development into a real-time technique.
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| 24. |
- Mandalenakis, Zacharias, 1979, et al.
(author)
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Atrial Fibrillation Burden in Young Patients with Congenital Heart Disease.
- 2018
-
In: Circulation. - 1524-4539. ; 137:9, s. 928-937
-
Journal article (peer-reviewed)abstract
- Background -Patients with congenital heart disease (CHD) are assumed to be vulnerable to atrial fibrillation (AF) due to residual shunts, anomalous vessel anatomy, progressive valvulopathy, hypertension, and atrial scars from previous heart surgery. However, the risk of developing AF as well as the complications associated with AF in children and young adults with CHD have not been compared with those in controls. Methods -Data from the Swedish Patient and Cause of Death Registers were used to identify all patients with a diagnosis of CHD who were born from 1970 to 1993. Each patient with CHD was matched by birth year, sex, and county with 10 controls from the Total Population Register in Sweden. Follow-up data were collected until 2011. Results -Among 21,982 patients (51.6% men) with CHD and 219,816 matched controls, 654 and 328 developed AF, respectively. The mean follow-up was 27 years. The risk of developing AF was 21.99 times higher (95% confidence interval, 19.26-25.12) in patients with CHD than controls. According to a hierarchic CHD classification, patients with conotruncal defects had the highest risk (hazard ratio, 84.27; 95% confidence interval, 56.86-124.89). At the age of 42 years, 8.3% of all patients with CHD had a recorded diagnosis of AF. Heart failure was the quantitatively most important complication in patients with CHD and AF, with a 10.7% (70/654) recorded diagnosis of heart failure. Conclusions -The risk of AF in children and young adults with CHD was 22 times higher than that in matched controls. Up to the age of 42 years, 1 of 12 patients with CHD had developed AF and 1 of 10 patients with CHD with AF had developed heart failure. The patient groups with the most complex congenital defects carried the greatest risk of AF and could be considered for targeted monitoring.
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| 25. |
- Mandalenakis, Zacharias, 1979, et al.
(author)
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Atrial natriuretic peptide as a predictor of atrial fibrillation in a male population study. The Study of Men Born in 1913 and 1923
- 2014
-
In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 171:1, s. 44-48
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Journal article (peer-reviewed)abstract
- Background: Atrial fibrillation is one of the most common arrhythmias in clinical practice and it is often diagnosed after a complication occurs. The study aimed to evaluate the predictive value of atrial natriuretic peptide (ANP) for atrial fibrillation in a male population-based study. Methods and results: This study is a part of the "Study of Men Born in 1913 and 1923", a longitudinal prospective cohort study of men, living in the city of Gothenburg in Sweden. A population-based sample of 528 men was investigated in 1988 when they were aged 65 years (n = 134) and 75 years (n = 394), and they were followed up for 16 years. Blood samples were collected from all 528 men at baseline and plasma ANP levels were analyzed by radioimmunoassay. Hazard ratios were estimated by competing-risk regression analysis. One hundred five participants were excluded because of a prior diagnosis of atrial fibrillation, congestive heart failure, severe hypertension, or severe chronic renal insufficiency. Of the remaining 423 participants, 90 men were diagnosed with atrial fibrillation over the 16-year follow-up. In multivariable analysis, men in the two highest quartiles of ANP levels had a significantly higher risk for atrial fibrillation compared with men in the lowest ANP quartile. The adjusted ratio was 3.14 (95% CI 1.59-6.20) for the third ANP quartile and 3.36 (95% CI 1.72-6.54) for the highest quartile of ANP level. Conclusions: In this population-based longitudinal study, we found that elevated ANP levels at baseline predicted atrial fibrillation during a follow-up time of 16 years.
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| 26. |
- Mandalenakis, Zacharias, 1979, et al.
(author)
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Ischemic Stroke in Children and Young Adults With Congenital Heart Disease
- 2016
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In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 5:2
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Journal article (peer-reviewed)abstract
- Background-Patients with congenital heart disease (CHD) may be at increased risk of ischemic stroke due to residual shunts, arrhythmias, and other cardiovascular abnormalities. We studied the relative risk and potential factors for developing ischemic stroke in children and young adults with CHD in Sweden. Methods and Results-All patients in the Swedish Patient Register with a diagnosis of CHD, born between 1970 and 1993, were identified and compared with 10 controls for each patient, matched for age, sex, and county and randomly selected from the general population. Follow-up data through 2011 were collected for both groups. Of 25 985 children and young adults with CHD (51.5% male, 48.5% female), 140 (0.5%) developed ischemic stroke. The hazard ratio for CHD patients developing ischemic stroke was 10.8 (95% CI, 8.5-13.6) versus controls. All major Marelli groups had significantly increased risk, but because of small CHD-group sizes, only atrial septal defect/patent foramen ovale, double-inlet ventricle, and aortic coarctation displayed significantly increased risk. In multivariate analysis of CHD patients, congestive heart failure carried the highest risk for developing ischemic stroke (hazard ratio 6.9 [95% CI, 4.7-10.3]), followed by hypertension and atrial fibrillation, which were also significantly associated with increased risk of ischemic stroke. Conclusions-The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
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| 27. |
- Mascher, Martin, et al.
(author)
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A chromosome conformation capture ordered sequence of the barley genome
- 2017
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 544:7651, s. 427-433
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Journal article (peer-reviewed)abstract
- Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
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| 28. |
- Månsson, Sven, et al.
(author)
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13C imaging-a new diagnostic platform.
- 2006
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In: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 16:1, s. 57-67
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Journal article (peer-reviewed)abstract
- he evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarization techniques, the signal from a given number of nuclei can be increased as much as 100,000 times, sufficient to enable imaging of nonproton nuclei. Technically, imaging of hyperpolarized nuclei offers several unique properties, such as complete lack of background signal and possibility for local and permanent destruction of the signal by means of radio frequency (RF) pulses. These properties allow for improved as well as new techniques within several application areas. Diagnostically, the injected compounds can visualize information about flow, perfusion, excretory function, and metabolic status. In this review article, we explain the concept of hyperpolarization and the techniques to hyperpolarize 13C. An overview of results obtained within angiography, perfusion, and catheter tracking is given, together with a discussion of the particular advantages and limitations. Finally, possible future directions of hyperpolarized 13C MRI are pointed out.
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| 29. |
- Månsson, Sven, et al.
(author)
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3He MRI-based assessment of posture-dependent regional ventilation gradients in rats
- 2005
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In: Journal of Applied Physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 98:6, s. 67-2259
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Journal article (peer-reviewed)abstract
- A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He breaths, which allowed for computation of a regional ventilation parameter. A group of six anesthetized rats was studied in both supine and prone postures. Three-dimensional maps of the ventilation parameter were obtained with high spatial resolution (voxel volume approximately 2 mm(3)). Vertical (dorsal-ventral) gradients of the ventilation index, defined as the regional ventilation normalized by the average ventilation within the whole lung, were investigated. Variations in the regional distribution of the ventilation parameter, as well as of the ventilation index, could be detected, depending on the posture of the rats. In supine posture, ventilation was elevated in the dependent parts of the lungs, with a linear gradient of the ventilation index of -0.11 +/- 0.03 cm(-1). In prone posture, the distribution of ventilation was more uniform, with a significantly (P < 0.001) smaller gradient of the ventilation index of -0.01 +/- 0.02 cm(-1). It is concluded that the (3)He MRI-based method can detect and quantify regional ventilation gradients in animals as small as the rat and that these gradients depend on prone or supine posture of the animal.
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| 30. |
- Persson, Carina Ulla, 1970, et al.
(author)
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Physical Activity Levels and Their Associations With Postural Control in the First Year After Stroke
- 2016
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In: Physical Therapy. - : Oxford University Press (OUP). - 0031-9023 .- 1538-6724. ; 96:9, s. 1389-1396
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Journal article (peer-reviewed)abstract
- Background. There is limited research concerning the physical activity levels over time of people who have survived stroke. Objective. The study objectives were: (1) to describe self-reported physical activity levels at 3, 6, and 12 months after stroke onset and (2) to analyze whether there was an association between self-reported physical activity level and postural control. Methods. Ninety-six participants with a first-ever stroke were assessed for self-reported physical activity levels with the Physical Activity Scale for the Elderly (PASE) in the first year after stroke. Postural control also was assessed with the modified version of the Postural Assessment Scale for Stroke Patients (SwePASS). Results. The raw median PASE scores at 3, 6, and 12 months after stroke were 59.5, 77.5, and 63.5, respectively. The model-estimated relative changes in mean PASE scores (as percentages) followed the same pattern, independent of age, sex, and SwePASS scores. Between 3 and 6 months after stroke, PASE scores increased by 32%, with no significant change between 3 and 12 months and between 6 and 12 months after stroke. For each unit increase in the SwePASS score at baseline,, there was a 13% increase in the PASE score during follow-up. Limitations. The sample size was limited. Although the PASE is based on the metabolic equivalent of the task, the actual physiological intensity of a person's performance of the activities is unknown. Conclusions. Self-reported physical activity levels were low in the first year after stroke. Good postural control in the first week after stroke onset was positively correlated with higher levels of self-reported physical activity in the first year after stroke.
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| 31. |
- Platt, Stephen M., et al.
(author)
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Atmospheric composition in the European Arctic and 30 years of the Zeppelin Observatory, Ny-Ålesund
- 2022
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In: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 22:5, s. 3321-3369
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Journal article (peer-reviewed)abstract
- The Zeppelin Observatory (78.90∘ N, 11.88∘ E) is located on Zeppelin Mountain at 472 m a.s.l. on Spitsbergen, the largest island of the Svalbard archipelago. Established in 1989, the observatory is part of Ny-Ålesund Research Station and an important atmospheric measurement site, one of only a few in the high Arctic, and a part of several European and global monitoring programmes and research infrastructures, notably the European Monitoring and Evaluation Programme (EMEP); the Arctic Monitoring and Assessment Programme (AMAP); the Global Atmosphere Watch (GAW); the Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS); the Advanced Global Atmospheric Gases Experiment (AGAGE) network; and the Integrated Carbon Observation System (ICOS). The observatory is jointly operated by the Norwegian Polar Institute (NPI), Stockholm University, and the Norwegian Institute for Air Research (NILU). Here we detail the establishment of the Zeppelin Observatory including historical measurements of atmospheric composition in the European Arctic leading to its construction. We present a history of the measurements at the observatory and review the current state of the European Arctic atmosphere, including results from trends in greenhouse gases, chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs), other traces gases, persistent organic pollutants (POPs) and heavy metals, aerosols and Arctic haze, and atmospheric transport phenomena, and provide an outline of future research directions.
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| 32. |
- Salomé, Nicolas, et al.
(author)
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Gastrectomy alters emotional reactivity in rats: neurobiological mechanisms.
- 2011
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In: The European journal of neuroscience. - : Wiley. - 1460-9568 .- 0953-816X. ; 33:9, s. 1685-95
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Journal article (peer-reviewed)abstract
- Gastrectomy (Gsx) is associated with altered emotional function and a predisposition to depression/anxiety disorders. Here we investigated the effects of Gsx on emotional reactivity in rats and explored the underlying neurobiological mechanisms. Gsx- and sham-operated rats were exposed to behavioural tests that explore anxiety- and depression-like behaviour (open field, black and white box, elevated plus maze, social interaction, forced swim) as well as memory (object recognition). The potential neurobiological mechanisms underlying these differences were explored by measuring (i) turnover of candidate neurotransmitter systems in the nucleus accumbens, (ii) hippocampal neurogenesis by BrdU labelling or by analysis of candidate genes involved in neuronal growth and (iii) changes in mRNA expression of candidate genes in dissected hippocampal and amygdala tissue. Data from individual behavioural tests as well as from multivariate analysis revealed differing emotional reactivity between Gsx- and sham-operated rats. Gsx rats showed reduced emotional reactivity in a new environment and decreased depression-like behaviour. Accumbal serotonin and dopamine turnover were both reduced in Gsx rats. Gsx also led to a memory deficit, although hippocampal neurogenesis was unaffected. Of the many candidate genes studied by real-time RT-PCR, we highlight a Gsx-associated decrease in expression of Egr-1, a transcription factor linked to neural plasticity and cognition, in the hippocampus and amygdala. Thus, Gsx induces an alteration of emotional reactivity and a memory/cognitive deficit that is associated with reduced turnover of serotonin and dopamine in the nucleus accumbens and decreased expression of Egr-1 in the hippocampus and amygdala.
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| 33. |
- Sjölinder, Mikael, et al.
(author)
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The Meningococcal Adhesin NhhA Provokes Proinflammatory Responses in Macrophages via Toll-Like Receptor 4-Dependent and -Independent Pathways
- 2012
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In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 80:11, s. 4027-4033
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Journal article (peer-reviewed)abstract
- Activation of macrophages by Toll-like receptors (TLRs) and functionally related proteins is essential for host defense and innate immunity. TLRs recognize a wide variety of pathogen-associated molecules. Here, we demonstrate that the meningococcal outer membrane protein NhhA has immunostimulatory functions and triggers release of proinflammatory cytokines from macrophages. NhhA-induced cytokine release was found to proceed via two distinct pathways in RAW 264.7 macrophages. Interleukin-6 (IL-6) secretion was dependent on activation of TLR4 and required the TLR signaling adaptor protein MyD88. In contrast, release of tumor necrosis factor (TNF) was TLR4 and MyD88 independent. Both pathways involved NF-kappa B-dependent gene regulation. Using a PCR-based screen, we could identify additional targets of NhhA-dependent gene activation such as the cytokines and growth factors IL-1 alpha, IL-1 beta, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF). In human monocyte-derived macrophages, G-CSF, GM-CSF, and IL-6 were found to be major targets of NhhA-dependent gene regulation. NhhA induced transcription of IL-6 and G-CSF mRNA via TLR4-dependent pathways, whereas GM-CSF transcription was induced via TLR4-independent pathways. These data provide new insights into the role of NhhA in host-pathogen interaction.
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| 34. |
- Skoglund, Martin
(author)
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Towards an assessment of safety and security interplay in automated driving systems.
- 2022
-
Licentiate thesis (other academic/artistic)abstract
- We are currently in the midst of significant changes in the road transport system, including the transformation to fossil-free propulsion and the shift to higher levels of automation. The next level in automation is soon upon us and is encompassed by the broader term Connected, Cooperative and Automated Mobility (CCAM) which is relevant for the entire transportation system. The introduction of CCAM has the potential to contribute significantly to crucial UN Sustainable Development Goals. For the automotive domain, the term Automated Driving Systems (ADS) is often used for highly automated vehicles. Notwithstanding the expected positive effects and the extraordinary efforts, highly automated driving systems are still not publicly available except in pilot programs.The increased complexity in the higher automation levels can be ascribed to the shift from fail-safe operator support to fail-operational systems that assume the operator's role, utilising new sensors and algorithms for perception and the reliance on connectivity to solve the problem task. Here the solution is also the problem, i.e. complex systems. The complexity of the systems and difficulties in capturing a complete practical description of the environment where the systems are intended to operate pose difficulties in defining validation procedures for ADS technologies' safety, security, and trustworthiness.Parallel to traditional safety issues, there is now a need to consider the quality of cybersecurity, e.g. due to external communication and environmental sensors being susceptible to remote attacks. A security problem may enable a hacker to incapacitate or fool an ADS resulting in unsafe behaviour. In addition to malicious misuse, the development of environment sensing has to consider functional insufficiencies of the employed sensor technologies. Therefore, both safety and security and their interplay must be addressed in developing the solutions.The first step in gaining public confidence in the technologies involved is to raise user awareness. Therefore there is a need to be transparent and explicit on the evaluation targets and the associated supporting evidence of safe and secure ADS. An assessment of safety and security properties performed by an independent organisation can be an essential step towards establishing trust in ADS solutions, bridging the gap between the marketing portrayal and the actual performance of such systems in operating conditions.This licentiate thesis contributes towards the overall goal of improving the assessment target and the associated supporting evidence of a safe and secure ADS in the automotive domain by (1) assessing requirements for safety, security and their interplay on key enabling technologies, (2) introducing an argument pattern enabling safety, security and interaction overlap to be jointly addressed, (3) proposing a method that enables assessment of security informed safety an independent agency.
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| 35. |
- Stack, Rebecca J., et al.
(author)
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Perceptions of risk and predictive testing held by the first-degree relatives of patients with rheumatoid arthritis in England, Austria and Germany : a qualitative study
- 2016
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In: BMJ Open. - : BMJ. - 2044-6055. ; 6:6
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Journal article (peer-reviewed)abstract
- Objectives The family members of patients with rheumatoid arthritis (RA) are at increased risk of developing RA and are potential candidates for predictive testing. This study explored the perceptions of first-degree relatives of people with RA about being at risk of RA and engaging in predictive testing. Methods 34 first-degree relatives (siblings and offspring) of patients with RA from the UK, Germany and Austria participated in semistructured interviews about their perceptions of RA risk and the prospect of predictive testing. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. Results First-degree relatives were aware of their susceptibility to RA, but were unsure of the extent of their risk. When considering their future risk, some relatives were concerned about the potential impact that RA would have on their lives. Relatives were concerned that knowing their actual risk would increase their anxiety and would affect decisions about their future. Also, relatives were concerned about the levels of uncertainty associated with predictive testing. Those in favour of knowing their future risk felt that they would need additional support to understand the risk information and cope with the emotional impact of this information. Conclusions Identifying individuals at risk of RA may allow targeted interventions to reduce the risk and consequence of future disease; however, relatives have concerns about predictive testing and risk information. The development of strategies to quantify and communicate risk needs to take these views into account and incorporate approaches to mitigate concerns and minimise the psychological impact of risk information.
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| 36. |
- Stewart, Rebecca I A, et al.
(author)
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Ecosystem services across the aquatic-terrestrial boundary : Linking ponds to pollination
- 2017
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In: Basic and Applied Ecology. - : Elsevier BV. - 1439-1791. ; 18, s. 13-20
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Journal article (peer-reviewed)abstract
- Many small farmland ponds are built for nutrient retention, the conservation of biodiversity or both, yet they are relatively neglected habitats. For example, little is known about the potential for ponds to influence populations of beneficial terrestrial insects, deliver ecosystem services across the aquatic-terrestrial boundary and affect crop yield in insect-pollinated cash crops.We assessed whether the presence of a pond affects the abundance of pollinators and the quality and quantity of strawberry yield. We compared the abundance of pollinators and the quality and quantity of strawberries between habitats adjacent to the pond, semi-natural terrestrial habitat and field border without semi-natural vegetation (control habitat).We found significantly higher abundances of syrphids and bees next to ponds compared to control habitats. Also, syrphids were significantly more abundant at pond habitats compared to vegetation habitats and a similar tendency, although not significant, was found for the abundance of bees. The quantity and quality of strawberries was significantly higher near the vegetation and pond habitats compared to the control habitats.Our result supports the theory that the presence of semi-natural habitats, in the agricultural landscape benefits both public interest in biodiversity conservation and farmers' interest in crop pollination. These benefits may also come from ponds as semi natural habitats. However, further studies are required to disentangle the effect of the pond per se and the effect of the associated terrestrial vegetation. Teiche werden in der Agrarlandschaft häufig zur Rückhaltung von Nährstoffen oder auch zur Erhaltung der Biodiversität eingerichtet, und dennoch wurden diese als Habitate bisher wenig beachtet. Daher ist kaum bekannt, ob Teiche über die aquatisch-terrestrische Grenze hinaus Ökosystem-Dienstleistungen unterstützen und Populationen nützlicher Insekten und somit landwirtschaftliche Erträge beeinflussen können. Wir untersuchten, ob das Vorhandensein eines Teiches sich auf die Abundanz der Bestäuber und die Qualität und Quantität der Erdbeerernte auswirkt. Wir verglichen die Abundanz der Bestäuber und die Qualität und Quantität von Erdbeeren im semi-natürlichen Habitaten neben Teichen (Teich), in semi-natürlichen terrestrischen Habitaten ohne Teich (Vegetation) und am Feldrand ohne semi-natürliche Habitate (Kontrolle). Wir fanden signifikant höhere Abundanzen von Schwebfliegen und Bienen neben Teichen im Vergleich zu Kontrollen. Schwebfliegen waren signifikant häufiger an Teichen als in semi-natürlichen Habitaten, und eine ähnliche Tendenz, wenn auch nicht signifikant, wurde für die Abundanz der Bienen gefunden. Die Quantität und Qualität der Erdbeeren war in semi-natürlicher Vegetation und an Teichen signifikant höher als in Kontrollen. Unsere Ergebnisse unterstützen die Annahme, dass das Vorhandensein von semi-natürlichen Habitaten in der Agrarlandschaft sowohl den öffentlichen Wunsch nach Erhaltung der Artenvielfalt als auch den Wunsch der Landwirte nach Bestäubung von Nutzpflanzen erfüllt. Allerdings sind weitere Untersuchungen erforderlich, um die Wirkung von Teichen per se und die Wirkung der zugehörigen terrestrischen Vegetation zu entschlüsseln.
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| 37. |
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