| 1. |
- Andersson, Roger, et al.
(author)
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Geografiskt focus och proto-industriell locus
- 1988
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In: Bebyggelsehistorisk tidskrift. - : Föreningen Bebyggelsehistorisk tidskrift. - 0349-2834 .- 2002-3812. ; :16, s. 93-109
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Journal article (peer-reviewed)
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| 3. |
- Dunér, Fredrik, et al.
(author)
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Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.
- 2010
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In: Nephron. Experimental nephrology. - : S. Karger AG. - 1660-2129. ; 116:2
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Journal article (peer-reviewed)abstract
- BACKGROUND/AIMS: It is still unclear what happens in the glomerulus when proteinuria starts. Using puromycin aminonucleoside nephrosis (PAN) rats, we studied early ultrastructural and permeability changes in relation to the expression of the podocyte-associated molecules nephrin, α-actinin, dendrin, and plekhh2, the last two of which were only recently discovered in podocytes. METHODS: Using immune stainings, semiquantitative measurement was performed under the electron microscope. Permeability was assessed using isolated kidney perfusion with tracers. Possible effects of ACE inhibition were tested. RESULTS: By day 2, some patchy foot process effacement, but no proteinuria, appeared. The amount of nephrin was reduced in both diseased and normal areas. The other proteins showed few changes, which were limited to diseased areas. By day 4, foot process effacement was complete and proteinuria appeared in parallel with signs of size barrier damage. Nephrin decreased further, while dendrin and plekhh2 also decreased but α-actinin remained unchanged. ACE inhibition had no significant protective effect. CONCLUSIONS: PAN glomeruli already showed significant pathology by day 4, despite relatively mild proteinuria. This was preceded by altered nephrin expression, supporting its pivotal role in podocyte morphology. The novel proteins dendrin and plekhh2 were both reduced, suggesting roles in PAN, whereas α-actinin was unchanged.
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| 4. |
- Einarsdottir, Elisabet, et al.
(author)
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The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease
- 2003
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In: European Journal of Human Genetics. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 11:1, s. 81-84
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Journal article (peer-reviewed)abstract
- We have identified a large family in the northern part of Sweden with multiple cases of autoimmune diseases, namely type 1 diabetes (T1D), Graves' disease (GD) and Hashimoto's thyroiditis (HT). The family members affected by any of these diseases share a region of 2.4 Mb that comprises among others the CTLA4 gene. We determined that all affected members of the family shared the HLA susceptibility haplotype (DR4-DQA1*0301-DQB1*0302). Analysis of genetic interaction conditioning for HLA haplotype provided strong evidence that the critical region which includes the CTLA4 gene acts together with the HLA locus on the etiology of disease (lodscore 4.20 (theta=0.0). The study of this family allowed us to: (1) reinforce a number of reports on linkage and association of the CTLA4 region to T1D and AITD; (2) demonstrate that a single haplotypic variant in this region constitutes an etiological factor to disease susceptibility in T1D, GD and HT; (3) reveal a strong genetic interaction of the CTLA4 and HLA loci in the genetic architecture of autoimmune disease; (4) emphasise the value of large pedigrees drawn from isolated populations as tools to single out the effect of individual loci in the etiology of complex diseases.
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| 5. |
- Grahn, Andreas, 1973-
(author)
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Fakta, normativitet eller pluralism? : Didaktiska typologier inom gymnasieskolans geografiundervining om klimatförändringar
- 2011
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Licentiate thesis (other academic/artistic)abstract
- In education about climate issues teachers make choices. What is of most importance? To know how the green house effect works in a natural scientific way or to know about the political processes that can help us find a solution? Habits, or selective traditions, answers the questions why, what and how does teachers do when teaching about climate issues. In this study selective traditions are investigated.The purpose of this study is to investigate and identify selective traditions among the Swedish geography teachers when it comes to teaching about global warming. A discussion about the implications of the selective traditions for the education from a pragmatic perspective, inspired by John Dewey in his work: “Democracy and Education is also included.The empiricism of the study consists of interviews where teachers tell about their ways of teaching about climate issues. The result is presented in the form of selective traditions. The study identifies three separate didactic typologies in teaching about climate issues. The natural science typology tradition which focuses on facts, the normative which focuses on changing the student’s attitudes and the pluralistic which focuses on the student’s democratic development. All three have different implications in a pragmatic perspective. These three didactic typologies have different implications for the democratic dimension in education. Typology 1 does not encourage the student to take part in debates about climate change. Instead the student only receives natural science facts. In Typology 2 it is the teacher or some other ruler who decides what attitudes to adapt. But in Typology 3 the student is encouraged to, and gets the opportunity to develop his- or hers own attitudes.
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| 6. |
- Haraldsson, Erik, et al.
(author)
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Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla
- 2015
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In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 50:11, s. 1419-1427
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Journal article (peer-reviewed)abstract
- Objective. The use of endoscopic papillectomy for resecting adenomas in the major duodenal papilla is increasing. This study focuses on the following three issues: Can endoscopic papillectomy be performed as a safe diagnostic and/or therapeutic procedure in biopsy-verified or suspected ampullary adenoma? Does expression of mutated KRAS in resected adenomatous tissue predict long-term outcome? What other factors may affect long-term outcome and should, therefore, be considered in decision making prior to endoscopic papillectomy? Material and methods. Thirty-six prospectively collected patients who underwent endoscopic papillectomy at Karolinska University Hospital between 2005 and 2014 were analyzed. Results. The rate of exact agreement between the histomorphological grading of the endoscopic biopsies and the papillectomy specimens was low (48%). Obstructive jaundice at presentation increased the risk of undetected adenocarcinoma (RR = 3.98; 95% CI = 1.46-10.85, p = 0.007). Lesions with malignancies were significantly larger (mean 30.6 mm) than those where only adenomas were found (mean 14.4 mm, p = 0.001). Mutated KRAS was detected in 9 of the 36 post-papillectomy specimens, including 4 of the 5 cases of ampullary adenocarcinoma. Eighteen cases were endoscopically cured after a mean follow-up period of 47 months (range 16-92 months). Conclusions. Endoscopic papillectomy is a valuable staging tool because of the limitations of endoscopic biopsy. Endoscopic papillectomy concomitantly offers a curative treatment for most patients with adenoma in the major duodenal papilla. Jaundice at presentation and large adenomas may indicate the presence of more advanced disease. Determination of mutated KRAS seems to be of limited value in predicting long-term outcome.
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| 7. |
- Haraldsson, Kjell
(author)
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Fritiden
- 1996
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In: Arbetarstaden Uppsala. - : Hedemora: Gidlunds förlag.
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Book chapter (other academic/artistic)
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| 11. |
- Haraldsson, Kjell, et al.
(author)
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Koll på Europa
- 2008
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Book (pop. science, debate, etc.)
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| 14. |
- Haraldsson, Kjell, et al.
(author)
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Koll på Sverige
- 2007
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Book (pop. science, debate, etc.)
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| 25. |
- Haraldsson, Kjell, 1950-, et al.
(author)
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Världen.
- 2009
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Book (pop. science, debate, etc.)
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| 28. |
- Kramming, Kajsa, 1974-
(author)
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Miljökollaps eller hållbar framtid? : Hur gymnasieungdomar uttrycker sig om miljöfrågor
- 2017
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Doctoral thesis (other academic/artistic)abstract
- This study investigates how young people in upper secondary school express them-selves about environmental issues. The aim of the study is to analyse how expres-sions about the environment can relate to policies of the concept of Education for Sustainable Development, ESD. The study put forward a view of environmental issues also being societal issues. Using a qualitative method of participatory model-ling, partakers creatively visualize their discussions in two workshop-assignments about either consumption or the future in the year 2050 in groups. Young peoples´ expressions about environmental issues can be described in accordance with two-parted ways of thinking about the environment and humanity, either as loosely or firmly connected. Not only do the two-parted ways of thinking apply to relation-ships between the environment and humanity, they are also used in describing a two-parted future trajectory towards either environmental collapse or sustainable futures. Moreover, ways of handling environmental issues are described as two-parted be-tween societal large-scale arrangements and individual efforts. Young people in the study express that they search for “right” things to do in order to reach a sustainable future. While not finding those prescribed solutions fulfilling or feasible either in education, or in society, feelings of powerlessness and hopelessness arise. Participants suggest there is one way to handle environmental issues and evade environmental collapse, which is to urgently turn negative trends into positive ones. Training young people in systemic and complicated ways of thinking open up for feelings of hope and may serve as empowerment in their comprehension of how they can live in the world today. The design, performance and discussions rendered by the study is first and foremost to be seen as a contribution to how young people in upper secondary school can be given time and space to participate in both cognitive and emotional meaning-making processes about environmental issues as societal issues.
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| 29. |
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| 30. |
- Nerdal, Kajsa, 1974-
(author)
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Gymnasieelevers presentationer av relationer mellan miljö och människor – en studie om utbildning för hållbar utveckling
- 2014
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Licentiate thesis (other academic/artistic)abstract
- This study investigates how upper secondary school students constitute relations between the environment and humanity. The aim of the study is to analyse relations that emerge between and within the Earth´s major systems (humanity included) and how these relations are composed when students are faced with a fictional decision of consuming a pair of jeans. Using workshop as a data collection method, students creatively visualize their discussions through participatory modelling in groups. The results of the study are based on the analyses of the concluding presentations of the completed models.The results show difficulties in submitting relations between the three dimensions of the concept of sustainable development together with a dualistic worldview, indicating a lack of complexity in the presentations. Therefore, a gap can be identified between the empirical results and the aims of education for sustainable development (ESD) that, according to the Ministry of Education and Research, should be a part of Swedish upper secondary education. In addition, a gap between the steering documents for the Swedish upper secondary schools and the UNESCO guidelines on ESD is revealed, consisting of the latter more distinctly promoting systems thinking and embracing pluralism. Three national programmes are represented in the study; social science, science and economics. Differences between the three are established. Groups with a focus on social science present complexity to higher extent than groups on science orientation. Groups with a focus on economics present least complexity in their presentations.
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| 31. |
- Röllgårdh, Martin, 1970-
(author)
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Bilder av lokal näringslivsutveckling : exemplet Värnamo
- 2011
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Licentiate thesis (other academic/artistic)abstract
- The main aim of this licentiate thesis is to examine how local actors in a medium-sized Swedish municipality, Värnamo, in their role as decision-makers at the local arena, describe and explain the preconditions and strategies for local economic and social development. The analysis uses semi-structured interviews to reveal the connections between the local actors representations of social and economic structures and their representations of central and future strategic choices. The local actors are represented by a) firm owners or central firm managers, b) local politicians in the municipal executive board, c) civil servants in central positions and d) key actors connected to local and regional organizations. The methodological approach is based on discourse analysis. The overall aim of the study is to understand how local discourses are constructed and communicated. The analysis is deepened by relating the local discourses to relevant theoretical models in contemporary economic geography. The economic-geographical theoretical models used in the analysis focus on industrial districts, clusters and innovation systems. Path-dependency, social embeddedness and creative class are other concepts of importance to understand the formation of the local discourse. The analysis shows how local discourses are affected by the perceived globalization process while being at the same time linked to a) specific historical and environmental factors leading to predominant behavioral norms and values stating that you should be hard working, economical, cooperative and trustworthy and b) the relative location, which is conceived to be central regarding communications and regional service functions. This is combined with an image of a creative and innovative local/regional production system, based on traditions in manufacturing and trade. The foundations in manufacturing and trade are however challenged by new sectors like logistics, design, and higher education in cooperation with universities in the region.
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| 32. |
- Skålén, Mikael
(author)
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Plats och entreprenörskap : fallet Åre
- 2011
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Licentiate thesis (other academic/artistic)abstract
- This licentiate thesis examines why Åre, the premium skiresort of Sweden, is so successful inproducing new small and medium sized firms. Since the 1980s, Åre has been among the highestranked Swedish municipalities when it comes to new firm formation, and their survial rateis better than in the rest of the country. Åre is situated in the interior north of Sweden, and isthe only comparable municipality in that part of the country that has increased its popultion inrecent years. Other similar municipalities are facing a heavy decline in population. Åre has along history in the tourist industry and most newly started firms are connected to this industry.Some 450 000 visitors come annually, mainly in the wintertime, to experience Åre, which hasthereby developed into a local market with demand on a broad range of products and services.The aim with the licentiate thesis is to analyse what is causing the entrepreneurial processthat is taking place in Åre. The theoretical point of departure is found in theories of contemporaryeconomic geography with concepts like social capital, cluster and ”creative class” formingthe framework for the analysis. Path-dependence theory is also in focus when it comes tounderstanding the importance of local history and its footprint of today.The main data used in the thesis come from 34 semi-structured interviews with companyowners/managers representing private firms in Åre. Only individuals that have started theirbusiness or taken over the firm from a family member have been of interest in the study. Thepurpose is to get close to the persons behind the business and reveal why they became entrepreneursin the local context. The mainly qualitative analysis of the interview material is supplementedby a statistical analysis where a) Åre is compared with other similar municipalitiesin Sweden concerning for example the development of new business or unemployment rates.And b) where all individuals who have lived in Åre during the period of 1990-2008 are analyzedusing different variables concerning socio-economic background and occupation.The thesis shows the importance of the attraction to the local environment where newfirms are formed as a result of a strong local market and an positive entrepreneurial atmospherethat exists in Åre. Entrepreneurs in Åre have a diverse background, but with the passionfor skiing or outdoor activities as common denominators. Another important factor is thegathering of local actors in the destination around a future oriented vision that unites them.
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