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1.	Bauer, S, et al. (author) Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model 2017 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 14620- Journal article (peer-reviewed)abstract Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies. We have developed a human microfluidic two-organ-chip model to study pancreatic islet–liver cross-talk based on insulin and glucose regulation. We have established a robust co-culture of human pancreatic islet microtissues and liver spheroids maintaining functional responses up to 15 days in an insulin-free medium. Functional coupling, demonstrated by insulin released from the islet microtissues in response to a glucose load applied in glucose tolerance tests on different days, promoted glucose uptake by the liver spheroids. Co-cultures maintained postprandial glucose concentrations in the circulation whereas glucose levels remained elevated in both single cultures. Thus, insulin secreted into the circulation stimulated glucose uptake by the liver spheroids, while the latter, in the absence of insulin, did not consume glucose as efficiently. As the glucose concentration fell, insulin secretion subsided, demonstrating a functional feedback loop between the liver and the insulin-secreting islet microtissues. Finally, inter-laboratory validation verified robustness and reproducibility. Further development of this model using tools inducing impaired glucose regulation should provide a unique in vitro system emulating human type 2 diabetes mellitus.
2.	Bauer, S, et al. (author) Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model 2018 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 1672- Journal article (peer-reviewed)abstract A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
3.	Hecht, JT, et al. (author) Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate 2004 In: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. - 0736-0266. ; 22:4, s. 759-767 Journal article (peer-reviewed)
4.	Herrington, WG, et al. (author) Cardiac, renal, and metabolic effects of sodium-glucose co-transporter 2 inhibitors: a position paper from the European Society of Cardiology ad-hoc task force on sodium-glucose co-transporter 2 inhibitors 2021 In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 23:8, s. 1260-1275 Journal article (peer-reviewed)
5.	Jakobsson, J., et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Journal article (peer-reviewed)
6.	Nogueira, RG, et al. (author) Global Impact of COVID-19 on Stroke Care and IV Thrombolysis 2021 In: Neurology. - 1526-632X. ; 96:23, s. E2824-E2838 Journal article (peer-reviewed)
7.	Bravo, L, et al. (author) 2021 swepub:Mat__t
8.	Tabiri, S, et al. (author) 2021 swepub:Mat__t

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Yang, H. (3); Liu, H. (3); Zhang, Y. (3); Sharma, S. (3); Martin, S. (3); Davies, M. (2); show more...; Evans, H. (2); Jones, G. (2); King, M. (2); Lopes, L. (2); Losada, M. (2); Martin, B. (2); Negri, G. (2); Nordberg, M. (2); Qureshi, A. (2); Robson, A. (2); Romano, M. (2); Shaw, K. (2); Ventura, D. (2); Wall, R. (2); Williams, S. (2); Zhang, H. (2); Morton, A. (2); Valente, P. (2); Davies, E (2); Banerjee, S. (2); Liu, T. (2); Bertoli, G (2); Stewart, G. (2); Martin, J. (2); Alves, R. (2); Aytac, E (2); Campain, N (2); Davies, RJ (2); Hompes, R (2); Lakkis, Z (2); McGrath, JS (2); Maciel, J (2); Rausa, E (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Brown, A. (2); James, A. (2); Cardoso, J. (2); Silva, M. (2); Diaz, S (2); Jones, M. (2); Manca, G. (2); Moore, R. (2); show less...

University: Karolinska Institutet (7); Umeå University (1); Stockholm University (1); Linköping University (1); Lund University (1); Swedish University of Agricultural Sciences (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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