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Search: WFRF:(He LQ)

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  • Betsholtz, C, et al. (author)
  • The glomerular transcriptome and proteome
  • 2007
  • In: Nephron. Experimental nephrology. - : S. Karger AG. - 1660-2129. ; 106:2, s. E32-E36
  • Journal article (peer-reviewed)abstract
    • Histopathology provides the current basis for classification and diagnosis of glomerular disorders. Molecular profiling methods, such as microarray analysis of mRNA expression, have rapidly emerged over the past years and are now applicable to minute amounts of tissue material, such as glomeruli from embryos or adult experimental animals, or from human renal needle biopsies. This review summarizes current efforts aiming at the determination of the glomerular transcriptome and proteome during development, in the healthy adult, and in disease. These studies are encouraging and show that comprehensive molecular profiling of the kidney glomerulus will most likely provide significant new insights into the normal structure and function of the glomerular filter, the molecular mechanisms of glomerular development, the diagnosis and classification of glomerular disease, and the pathogenic mechanisms underlying the stepwise breakdown of glomerular filter function that accompanies several common systemic disorders.
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  • Xiao, ZJ, et al. (author)
  • Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria
  • 2011
  • In: Nephron. Experimental nephrology. - : S. Karger AG. - 1660-2129. ; 118:3, s. E39-E48
  • Journal article (peer-reviewed)abstract
    • <i>Background/Aims:</i> The organization of actin cytoskeleton in podocyte foot processes plays a critical role in the maintenance of the glomerular filtration barrier. The cAMP pathway is an important regulator of the actin network assembly in cells. However, the role of the cAMP pathway in podocytes is not well understood. Type 1 adenylate cyclase (Adcy1), previously thought to be specific for neuronal tissue, is a member of the family of enzymes that catalyses the formation of cAMP. In this study, we characterized the expression and role of A<i>dcy1</i> in the kidney. <i>Methods:</i> Expression of Adcy1 was studied by RT-PCR, Northern blotting and in situ hybridization. The role of <i>Adcy1</i> in podocytes was investigated by analyzing <i>Adcy1</i> knockout mice (Adcy1–/–). <i>Results and Conclusion:</i> Adcy1 is expressed in the kidney specifically by podocytes. In the kidney, Adcy1 does not have a critical role in normal physiological functioning as kidney histology and function are normal in Adcy1–/– mice. However, albumin overload resulted in severe albuminuria in Adcy1–/– mice, whereas wild-type control mice showed only mild albumin leakage to urine. In conclusion, we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus.
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  • Result 1-23 of 23

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