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- Bousquet, J, et al.
(author)
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CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis : A SUNFRAIL report
- 2017
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In: Clinical and Translational Allergy. - : Wiley. - 2045-7022. ; 7:1
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Research review (peer-reviewed)abstract
- A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Reference Sites Network for Prevention and Care of Frailty and Chronic Conditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the 28 items of JA-CHRODIS. A short summary was proposed for each item and 18 experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28 items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CHRODIS recommendations for the evaluation of Good Practices.
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- Rolandsson, Margot, et al.
(author)
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Effects of snuff on oral health status of adolescent males : A case-control study
- 2005
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In: Oral Health and Preventive Dentistry. ; 3:2, s. 77-85
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Journal article (peer-reviewed)abstract
- The purpose of this study was to investigate effects of snuff on the oral health status of adolescent males. MATERIALS AND METHODS: The participants consisted of 80 adolescent males between 16-25 years, 40 snuff users and 40 non-users. The snuff users and non-users were matched with reference to their age. Data were collected using a questionnaire containing questions on general and oral health, daily oral hygiene and tobacco habits. The clinical examination was carried out in a dental office by two experienced dental hygienists. Snuff lesions were clinically classified on a four-point scale and documented on colour slides. The examination also assessed the number of teeth, restored tooth surfaces, plaque index and gingival index, probing pocket depth and gingival recessions. RESULTS: Out of 40 snuff users, 35 showed snuff incluced lesions. The clinical diagnosis of snuff users' mucosa showed snuff lesions of different severity clinically classified as degree 1, 2 and 3. When explaining snuff lesions of degree 2 and 3, hours of daily snuff use and package form (portion-bag snuff versus loose snuff) was statistically significant. There were no statistical differences between snuff users and non-users regarding restored tooth surfaces, presence of plaque, gingival inflammation and probing pocket depth. Seventeen percent of the cases showed loss of periodontal attachment as gingival recessions. CONCLUSION: In spite of mucosal lesions caused by snuff there were no statistical differences in prevalence in plaque and gingivitis between snuff users and non-users. However, some cases showed loss of periodontal attachment as gingival recessions.
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| 11. |
- Kjellander Hellqvist, Eva, 1965-, et al.
(author)
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Ämnesspråk i klassrummet
- 2018
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In: Musikforskning idag 2018, Uppsala 13–15 juni. - Uppsala : Uppsala University. ; , s. 8-8
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Conference paper (other academic/artistic)abstract
- Som en del i ett större projekt om ämnesspråk vid Centrum för ämnesdidaktisk forskning vid Linnéuniversitetet (CÄHL), studerar vi ämnesspråket i högstadiets klassrumsundervisning i musik. Studien är deskriptiv till sin karaktär, och syftet är primärt att beskriva hur ämnesspråket i musikundervisningen på högstadiet gestaltar sig. Studien baseras på filminspelningar av sex lektioner i musik runt om i södra Sverige.Två centrala utgångspunkter för studien är att det finns ett ämnesspråk i musikundervisningen och att det är multimodalt till sin karaktär. Det vill säga att ämnesspråket inte enkelt kan beskrivas som något som sägs (verbalt) eller gestaltas genom olika skriftliga strategier (exv. på tavlan, i textmaterial och liknande).Vid Musikforskning i dag vill vi ge en överblick över vilka olika former av ”språk” (vardagligt,skolspråk, ämnesspråk, ”musikerspråk”, vetenskapligt språk) som förekommer i de lektioner vihar dokumenterat. Därefter vill vi beskriva de delar av materialet som vi har kategoriserat som ämnesspråk och ge exempel på hur vi arbetat med dem utifrån ett multimodalt perspektiv i vår analys. Mer specifikt analyserar vi det insamlade materialet utifrån ett social-semiotiskt perspektiv med fokus på vilka semiotiska resurser som lärarna använder sig av i sin undervisning.Studiens preliminära resultat visar att olika semiotiska resurser såsom tal, skrift, sång, instrumentspelande, gestik och liknande, ofta samverkar för att framföra ett innehåll i undervisningen. Dessutom samsas musikundervisningens ämnesspråk, med språk från andra domäner, såsom skolspråk, vardagsspråk, ”musikerspråk”, vetenskapligt språk.
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- Mörck, Catarina, 1972, et al.
(author)
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Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans
- 2009
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:43, s. 18285-90
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Journal article (peer-reviewed)abstract
- Statins are compounds prescribed to lower blood cholesterol in millions of patients worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway that leads to the synthesis of farnesyl pyrophosphate, a precursor for cholesterol synthesis and the source of lipid moieties for protein prenylation. The nematode Caenorhabditis elegans possesses a mevalonate pathway that lacks the branch leading to cholesterol synthesis, and thus represents an ideal organism to specifically study the noncholesterol roles of the pathway. Inhibiting HMG-CoA reductase in C. elegans using statins or RNAi leads to developmental arrest and loss of membrane association of a GFP-based prenylation reporter. The unfolded protein response (UPR) is also strongly activated, suggesting that impaired prenylation of small GTPases leads to the accumulation of unfolded proteins and ER stress. UPR induction was also observed upon pharmacological inhibition of farnesyl transferases or RNAi inhibition of a specific isoprenoid transferase (M57.2) and found to be dependent on both ire-1 and xbp-1 but not on pek-1 or atf-6, which are all known regulators of the UPR. The lipid stores and fatty acid composition were unaffected in statin-treated worms, even though they showed reduced staining with Nile red. We conclude that inhibitors of HMG-CoA reductase or of farnesyl transferases induce the UPR by inhibiting the prenylation of M57.2 substrates, resulting in developmental arrest in C. elegans. These results provide a mechanism for the pleiotropic effects of statins and suggest that statins could be used clinically where UPR activation may be of therapeutic benefit.
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| 13. |
- Rietz, H, et al.
(author)
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LONG SLEEP DURATION AND AMBULATORY BLOOD PRESSURE
- 2022
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In: JOURNAL OF HYPERTENSION. - : Ovid Technologies (Wolters Kluwer Health). - 0263-6352 .- 1473-5598. ; 40:SUPPL 1, s. E128-E128
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Conference paper (other academic/artistic)
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