| 1. |
- Aad, G., et al.
(author)
-
- 2012
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Journal article (peer-reviewed)
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| 2. |
- Munk, P., et al.
(author)
-
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
- 2022
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
-
Journal article (peer-reviewed)abstract
- Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
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| 3. |
- Faatz, B., et al.
(author)
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Simultaneous operation of two soft x-ray free-electron lasers driven by one linear accelerator
- 2016
-
In: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 18
-
Journal article (peer-reviewed)abstract
- Extreme-ultraviolet to x-ray free-electron lasers (FELs) in operation for scientific applications are up to now single-user facilities. While most FELs generate around 100 photon pulses per second, FLASH at DESY can deliver almost two orders of magnitude more pulses in this time span due to its superconducting accelerator technology. This makes the facility a prime candidate to realize the next step in FELs-dividing the electron pulse trains into several FEL lines and delivering photon pulses to several users at the same time. Hence, FLASH has been extended with a second undulator line and self-amplified spontaneous emission (SASE) is demonstrated in both FELs simultaneously. FLASH can now deliver MHz pulse trains to two user experiments in parallel with individually selected photon beam characteristics. First results of the capabilities of this extension are shown with emphasis on independent variation of wavelength, repetition rate, and photon pulse length.
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| 4. |
- Fukui, A., et al.
(author)
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TOI-1749: an M dwarf with a Trio of Planets including a Near-resonant Pair
- 2021
-
In: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 162:4
-
Journal article (peer-reviewed)abstract
- We report the discovery of one super-Earth- (TOI-1749b) and two sub-Neptune-sized planets (TOI-1749c and TOI-1749d) transiting an early M dwarf at a distance of 100 pc, which were first identified as planetary candidates using data from the TESS photometric survey. We have followed up this system from the ground by means of multiband transit photometry, adaptive optics imaging, and low-resolution spectroscopy, from which we have validated the planetary nature of the candidates. We find that TOI-1749b, c, and d have orbital periods of 2.39, 4.49, and 9.05 days, and radii of 1.4, 2.1, and 2.5 R (circle plus), respectively. We also place 95% confidence upper limits on the masses of 57, 14, and 15 M (circle plus) for TOI-1749b, c, and d, respectively, from transit timing variations. The periods, sizes, and tentative masses of these planets are in line with a scenario in which all three planets initially had a hydrogen envelope on top of a rocky core, and only the envelope of the innermost planet has been stripped away by photoevaporation and/or core-powered mass-loss mechanisms. These planets are similar to other planetary trios found around M dwarfs, such as TOI-175b,c,d and TOI-270b,c,d, in the sense that the outer pair has a period ratio within 1% of 2. Such a characteristic orbital configuration, in which an additional planet is located interior to a near 2:1 period-ratio pair, is relatively rare around FGK dwarfs.
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| 5. |
- Rauer, H., et al.
(author)
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The PLATO 2.0 mission
- 2014
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In: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 38:1-2, s. 249-330
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Journal article (peer-reviewed)abstract
- PLATO 2.0 has recently been selected for ESA's M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental questions such as: How do planetary systems form and evolve? Are there other systems with planets like ours, including potentially habitable planets? The PLATO 2.0 instrument consists of 34 small aperture telescopes (32 with 25 s readout cadence and 2 with 2.5 s cadence) providing a wide field-of-view (2232 deg(2)) and a large photometric magnitude range (4-16 mag). It focuses on bright (4-11 mag) stars in wide fields to detect and characterize planets down to Earth-size by photometric transits, whose masses can then be determined by ground-based radial-velocity follow-up measurements. Asteroseismology will be performed for these bright stars to obtain highly accurate stellar parameters, including masses and ages. The combination of bright targets and asteroseismology results in high accuracy for the bulk planet parameters: 2 %, 4-10 % and 10 % for planet radii, masses and ages, respectively. The planned baseline observing strategy includes two long pointings (2-3 years) to detect and bulk characterize planets reaching into the habitable zone (HZ) of solar-like stars and an additional step-and-stare phase to cover in total about 50 % of the sky. PLATO 2.0 will observe up to 1,000,000 stars and detect and characterize hundreds of small planets, and thousands of planets in the Neptune to gas giant regime out to the HZ. It will therefore provide the first large-scale catalogue of bulk characterized planets with accurate radii, masses, mean densities and ages. This catalogue will include terrestrial planets at intermediate orbital distances, where surface temperatures are moderate. Coverage of this parameter range with statistical numbers of bulk characterized planets is unique to PLATO 2.0. The PLATO 2.0 catalogue allows us to e. g.: - complete our knowledge of planet diversity for low-mass objects, - correlate the planet mean density-orbital distance distribution with predictions from planet formation theories,- constrain the influence of planet migration and scattering on the architecture of multiple systems, and - specify how planet and system parameters change with host star characteristics, such as type, metallicity and age. The catalogue will allow us to study planets and planetary systems at different evolutionary phases. It will further provide a census for small, low-mass planets. This will serve to identify objects which retained their primordial hydrogen atmosphere and in general the typical characteristics of planets in such a low-mass, low-density range. Planets detected by PLATO 2.0 will orbit bright stars and many of them will be targets for future atmosphere spectroscopy exploring their atmospheres. Furthermore, the mission has the potential to detect exomoons, planetary rings, binary and Trojan planets. The planetary science possible with PLATO 2.0 is complemented by its impact on stellar and galactic science via asteroseismology as well as light curves of all kinds of variable stars, together with observations of stellar clusters of different ages. This will allow us to improve stellar models and study stellar activity. A large number of well-known ages from red giant stars will probe the structure and evolution of our Galaxy. Asteroseismic ages of bright stars for different phases of stellar evolution allow calibrating stellar age-rotation relationships. Together with the results of ESA's Gaia mission, the results of PLATO 2.0 will provide a huge legacy to planetary, stellar and galactic science.
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| 6. |
- Luque, R., et al.
(author)
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A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067
- 2023
-
In: Nature. - 0028-0836 .- 1476-4687. ; 623:7989, s. 932-937
-
Journal article (peer-reviewed)abstract
- Planets with radii between that of the Earth and Neptune (hereafter referred to as ‘sub-Neptunes’) are found in close-in orbits around more than half of all Sun-like stars 1,2. However, their composition, formation and evolution remain poorly understood 3. The study of multiplanetary systems offers an opportunity to investigate the outcomes of planet formation and evolution while controlling for initial conditions and environment. Those in resonance (with their orbital periods related by a ratio of small integers) are particularly valuable because they imply a system architecture practically unchanged since its birth. Here we present the observations of six transiting planets around the bright nearby star HD 110067. We find that the planets follow a chain of resonant orbits. A dynamical study of the innermost planet triplet allowed the prediction and later confirmation of the orbits of the rest of the planets in the system. The six planets are found to be sub-Neptunes with radii ranging from 1.94R ⊕ to 2.85R ⊕. Three of the planets have measured masses, yielding low bulk densities that suggest the presence of large hydrogen-dominated atmospheres.
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| 7. |
- Burch, J. L., et al.
(author)
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Electron-scale measurements of magnetic reconnection in space
- 2016
-
In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 352:6290, s. 1189-
-
Research review (peer-reviewed)abstract
- Magnetic reconnection is a fundamental physical process in plasmas whereby stored magnetic energy is converted into heat and kinetic energy of charged particles. Reconnection occurs in many astrophysical plasma environments and in laboratory plasmas. Using measurements with very high time resolution, NASA's Magnetospheric Multiscale (MMS) mission has found direct evidence for electron demagnetization and acceleration at sites along the sunward boundary of Earth's magnetosphere where the interplanetary magnetic field reconnects with the terrestrial magnetic field. We have (i) observed the conversion of magnetic energy to particle energy; (ii) measured the electric field and current, which together cause the dissipation of magnetic energy; and (iii) identified the electron population that carries the current as a result of demagnetization and acceleration within the reconnection diffusion/dissipation region.
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| 8. |
- Codilean, A. T., et al.
(author)
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OCTOPUS database (v.2)
- 2022
-
In: Earth System Science Data. - : Copernicus GmbH. - 1866-3508 .- 1866-3516. ; 14:8, s. 3695-3713
-
Journal article (peer-reviewed)abstract
- OCTOPUS v.2 is an Open Geospatial Consortium (OGC) compliant web-enabled database that allows users to visualise, query, and download cosmogenic radionuclide, luminescence, and radiocarbon ages and denudation rates associated with erosional landscapes, Quaternary depositional landforms, and archaeological records, along with ancillary geospatial (vector and raster) data layers. The database follows the FAIR (Findability, Accessibility, Interoperability, and Reuse) data principles and is based on open-source software deployed on the Google Cloud Platform. Data stored in the database can be accessed via a custom-built web interface and via desktop geographic information system (GIS) applications that support OGC data access protocols. OCTOPUS v.2 hosts five major data collections. CRN Denudation and ExpAge consist of published cosmogenic Be-10 and Al-26 measurements in modern fluvial sediment and glacial samples respectively. Both collections have a global extent; however, in addition to geospatial vector layers, CRN Denudation also incorporates raster layers, including a digital elevation model, gradient raster, flow direction and flow accumulation rasters, atmospheric pressure raster, and CRN production scaling and topographic shielding factor rasters. SahulSed consists of published optically stimulated luminescence (OSL) and thermoluminescence (TL) ages for fluvial, aeolian, and lacustrine sedimentary records across the Australian mainland and Tasmania. SahulArch consists of published OSL, TL, and radiocarbon ages for archaeological records, and FosSahul consists of published late-Quaternary records of direct and indirect non-human vertebrate (mega)fauna fossil ages that have been systematically quality rated. Supporting data are comprehensive and include bibliographic, contextual, and sample-preparation- and measurement-related information. In the case of cosmogenic radionuclide data, OCTOPUS also includes all necessary information and input files for the recalculation of denudation rates using the open-source program CAIRN. OCTOPUS v.2 and its associated data curation framework allow for valuable legacy data to be harnessed that would otherwise be lost to the research community. The database can be accessed at https://octopusdata.org (last access: 1 July 2022). The individual data collections can also be accessed via their respective digital object identifiers (DOIs) (see Table 1).
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| 9. |
- Fuselier, S. A., et al.
(author)
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Mass Loading the Earth's Dayside Magnetopause Boundary Layer and Its Effect on Magnetic Reconnection
- 2019
-
In: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007. ; 46:12, s. 6204-6213
-
Journal article (peer-reviewed)abstract
- When the interplanetary magnetic field is northward for a period of time, O+ from the high-latitude ionosphere escapes along reconnected magnetic field lines into the dayside magnetopause boundary layer. Dual-lobe reconnection closes these field lines, which traps O+ and mass loads the boundary layer. This O+ is an additional source of magnetospheric plasma that interacts with magnetosheath plasma through magnetic reconnection. This mass loading and interaction is illustrated through analysis of a magnetopause crossing by the Magnetospheric Multiscale spacecraft. While in the O+-rich boundary layer, the interplanetary magnetic field turns southward. As the Magnetospheric Multiscale spacecraft cross the high-shear magnetopause, reconnection signatures are observed. While the reconnection rate is likely reduced by the mass loading, reconnection is not suppressed at the magnetopause. The high-latitude dayside ionosphere is therefore a source of magnetospheric ions that contributes often to transient reduction in the reconnection rate at the dayside magnetopause.
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| 10. |
- Genestreti, K. J., et al.
(author)
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MMS Observation of Asymmetric Reconnection Supported by 3-D Electron Pressure Divergence
- 2018
-
In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 123:3, s. 1806-1821
-
Journal article (peer-reviewed)abstract
- We identify the electron diffusion region (EDR) of a guide field dayside reconnection site encountered by the Magnetospheric Multiscale (MMS) mission and estimate the terms in generalized Ohm's law that controlled energy conversion near the X-point. MMS crossed the moderate-shear (similar to 130 degrees) magnetopause southward of the exact X-point. MMS likely entered the magnetopause far from the X-point, outside the EDR, as the size of the reconnection layer was less than but comparable to the magnetosheath proton gyroradius, and also as anisotropic gyrotropic "outflow" crescent electron distributions were observed. MMS then approached the X-point, where all four spacecraft simultaneously observed signatures of the EDR, for example, an intense out-of-plane electron current, moderate electron agyrotropy, intense electron anisotropy, nonideal electric fields, and nonideal energy conversion. We find that the electric field associated with the nonideal energy conversion is (a) well described by the sum of the electron inertial and pressure divergence terms in generalized Ohms law though (b) the pressure divergence term dominates the inertial term by roughly a factor of 5:1, (c) both the gyrotropic and agyrotropic pressure forces contribute to energy conversion at the X-point, and (d) both out-of-the-reconnection-plane gradients (partial derivative/partial derivative M) and in-plane (partial derivative/partial derivative L, N) in the pressure tensor contribute to energy conversion near the X-point. This indicates that this EDR had some electron-scale structure in the out-of-plane direction during the time when (and at the location where) the reconnection site was observed.
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| 11. |
- Hasegawa, H., et al.
(author)
-
Magnetic Field Annihilation in a Magnetotail Electron Diffusion Region With Electron-Scale Magnetic Island
- 2022
-
In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 127:7
-
Journal article (peer-reviewed)abstract
- We present observations in Earth's magnetotail by the Magnetospheric Multiscale spacecraft that are consistent with magnetic field annihilation, rather than magnetic topology change, causing fast magnetic-to-electron energy conversion in an electron-scale current sheet. Multi-spacecraft analysis for the magnetic field reconstruction shows that an electron-scale magnetic island was embedded in the observed electron diffusion region (EDR), suggesting an elongated shape of the EDR. Evidence for the annihilation was revealed in the form of the island growing at a rate much lower than expected for the standard X-type geometry of the EDR, which indicates that magnetic flux injected into the EDR was not ejected from the X-point or accumulated in the island, but was dissipated in the EDR. This energy conversion process is in contrast to that in the standard EDR of a reconnecting current sheet where the energy of antiparallel magnetic fields is mostly converted to electron bulk-flow energy. Fully kinetic simulation also demonstrates that an elongated EDR is subject to the formation of electron-scale magnetic islands in which fast but transient annihilation can occur. Consistent with the observations and simulation, theoretical analysis shows that fast magnetic diffusion can occur in an elongated EDR in the presence of nongyrotropic electron effects. We suggest that the annihilation in elongated EDRs may contribute to the dissipation of magnetic energy in a turbulent collisionless plasma.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Burch, J. L., et al.
(author)
-
Localized Oscillatory Energy Conversion in Magnetopause Reconnection
- 2018
-
In: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007. ; 45:3, s. 1237-1245
-
Journal article (peer-reviewed)abstract
- Data from the NASA Magnetospheric Multiscale mission are used to investigate asymmetric magnetic reconnection at the dayside boundary between the Earth's magnetosphere and the solar wind. High-resolution measurements of plasmas and fields are used to identify highly localized (similar to 15 electron Debye lengths) standing wave structures with large electric field amplitudes (up to 100 mV/m). These wave structures are associated with spatially oscillatory energy conversion, which appears as alternatingly positive and negative values of J . E. For small guide magnetic fields the wave structures occur in the electron stagnation region at the magnetosphere edge of the electron diffusion region. For larger guide fields the structures also occur near the reconnection X-line. This difference is explained in terms of channels for the out-of-plane current (agyrotropic electrons at the stagnation point and guide field-aligned electrons at the X-line).
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| 16. |
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| 17. |
- Ergun, R. E., et al.
(author)
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Drift waves, intense parallel electric fields, and turbulence associated with asymmetric magnetic reconnection at the magnetopause
- 2017
-
In: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 44:7, s. 2978-2986
-
Journal article (peer-reviewed)abstract
- Observations of magnetic reconnection at Earth's magnetopause often display asymmetric structures that are accompanied by strong magnetic field (B) fluctuations and large-amplitude parallel electric fields (E-||). The B turbulence is most intense at frequencies above the ion cyclotron frequency and below the lower hybrid frequency. The B fluctuations are consistent with a thin, oscillating current sheet that is corrugated along the electron flow direction (along the X line), which is a type of electromagnetic drift wave. Near the X line, electron flow is primarily due to a Hall electric field, which diverts ion flow in asymmetric reconnection and accompanies the instability. Importantly, the drift waves appear to drive strong parallel currents which, in turn, generate large-amplitude (similar to 100mV/m) E-|| in the form of nonlinear waves and structures. These observations suggest that turbulence may be common in asymmetric reconnection, penetrate into the electron diffusion region, and possibly influence the magnetic reconnection process.
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| 18. |
- Ergun, R. E., et al.
(author)
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Magnetic Reconnection, Turbulence, and Particle Acceleration : Observations in the Earth's Magnetotail
- 2018
-
In: Geophysical Research Letters. - : Blackwell Publishing Ltd. - 0094-8276 .- 1944-8007. ; 45:8, s. 3338-3347
-
Journal article (peer-reviewed)abstract
- We report observations of turbulent dissipation and particle acceleration from large-amplitude electric fields (E) associated with strong magnetic field (B) fluctuations in the Earth's plasma sheet. The turbulence occurs in a region of depleted density with anti-earthward flows followed by earthward flows suggesting ongoing magnetic reconnection. In the turbulent region, ions and electrons have a significant increase in energy, occasionally >100 keV, and strong variation. There are numerous occurrences of |E| >100 mV/m including occurrences of large potentials (>1 kV) parallel to B and occurrences with extraordinarily large J · E (J is current density). In this event, we find that the perpendicular contribution of J · E with frequencies near or below the ion cyclotron frequency (fci) provide the majority net positive J · E. Large-amplitude parallel E events with frequencies above fci to several times the lower hybrid frequency provide significant dissipation and can result in energetic electron acceleration.
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| 19. |
- Eriksson, S., et al.
(author)
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Magnetospheric Multiscale Observations of the Electron Diffusion Region of Large Guide Field Magnetic Reconnection
- 2016
-
In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 117:1
-
Journal article (peer-reviewed)abstract
- We report observations from the Magnetospheric Multiscale (MMS) satellites of a large guide field magnetic reconnection event. The observations suggest that two of the four MMS spacecraft sampled the electron diffusion region, whereas the other two spacecraft detected the exhaust jet from the event. The guide magnetic field amplitude is approximately 4 times that of the reconnecting field. The event is accompanied by a significant parallel electric field (E-parallel to)that is larger than predicted by simulations. The high-speed (similar to 300 km/s) crossing of the electron diffusion region limited the data set to one complete electron distribution inside of the electron diffusion region, which shows significant parallel heating. The data suggest that E-parallel to is balanced by a combination of electron inertia and a parallel gradient of the gyrotropic electron pressure.
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| 20. |
- Fuselier, S. A., et al.
(author)
-
High-density O+ in Earth's outer magnetosphere and its effect on dayside magnetopause magnetic reconnection
- 2019
-
In: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 124:12, s. 10257-10269
-
Journal article (peer-reviewed)abstract
- The warm plasma cloak is a source of magnetospheric plasma that contain significant O+. When the O+ density in the magnetosphere near the magnetopause is >0.2 cm(-3) and the H+ density is <1.5 cm(-3), then O+ dominates the magnetospheric ion mass density by more than a factor of 2. A survey is conducted of such O+-rich warm plasma cloak intervals and their effect on reconnection at the Earth's magnetopause. The survey uses data from the Magnetospheric Multiscale mission (MMS) and the results are compared and combined with a previous survey of the warm plasma cloak. Overall, the warm plasma cloak and the O+-rich warm plasma cloak reduce the magnetopause reconnection rate by >20% due to mass-loading only about 2% to 4% of the time. However, during geomagnetic storms, O+ dominates the mass density of the warm plasma cloak and these mass densities are very high. Therefore, a separate study is conducted to determine the effect of the warm plasma cloak on magnetopause reconnection during geomagnetically disturbed times. This study shows that the warm plasma cloak reduces the reconnection rate significantly about 25% of the time during disturbed conditions.
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| 21. |
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| 22. |
- Torbert, R. B., et al.
(author)
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Electron-scale dynamics of the diffusion region during symmetric magnetic reconnection in space
- 2018
-
In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 362:6421, s. 1391-1395
-
Journal article (peer-reviewed)abstract
- Magnetic reconnection is an energy conversion process that occurs in many astrophysical contexts including Earth's magnetosphere, where the process can be investigated in situ by spacecraft. On 11 July 2017, the four Magnetospheric Multiscale spacecraft encountered a reconnection site in Earth's magnetotail, where reconnection involves symmetric inflow conditions. The electron-scale plasma measurements revealed (i) super-Alfvenic electron jets reaching 15,000 kilometers per second; (ii) electron meandering motion and acceleration by the electric field, producing multiple crescent-shaped structures in the velocity distributions; and (iii) the spatial dimensions of the electron diffusion region with an aspect ratio of 0.1 to 0.2, consistent with fast reconnection. The well-structured multiple layers of electron populations indicate that the dominant electron dynamics are mostly laminar, despite the presence of turbulence near the reconnection site.
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| 23. |
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| 24. |
- Albani, S, et al.
(author)
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Twelve thousand years of dust : the Holocene global dust cycle constrained by natural archives
- 2015
-
In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 11:6, s. 869-903
-
Journal article (peer-reviewed)abstract
- Mineral dust plays an important role in the climate system by interacting with radiation, clouds, and biogeochemical cycles. In addition, natural archives show that the dust cycle experienced variability in the past in response to global and local climate change. The compilation of the DIRTMAP paleodust datasets in the last two decades provided a target for paleoclimate models that include the dust cycle, following a time slice approach. We propose an innovative framework to organize a paleodust dataset that moves on from the positive experience of DIRTMAP and takes into account new scientific challenges, by providing a concise and accessible dataset of temporally resolved records of dust mass accumulation rates and particle grain-size distributions. We consider data from ice cores, marine sediments, loess/paleosol sequences, lake sediments, and peat bogs for this compilation, with a temporal focus on the Holocene period. This global compilation allows investigation of the potential, uncertainties and confidence level of dust mass accumulation rates reconstructions, and highlights the importance of dust particle size information for accurate and quantitative reconstructions of the dust cycle. After applying criteria that help to establish that the data considered represent changes in dust deposition, 43 paleodust records have been identified, with the highest density of dust deposition data occurring in the North Atlantic region. Although the temporal evolution of dust in the North Atlantic appears consistent across several cores and suggest that minimum dust fluxes are likely observed during the Early to mid-Holocene period (6000–8000 years ago), the magnitude of dust fluxes in these observations is not fully consistent, suggesting that more work needs to be done to synthesize datasets for the Holocene. Based on the data compilation, we used the Community Earth System Model to estimate the mass balance and variability of the global dust cycle during the Holocene, with dust load ranging from 17.1 to 20.5 Tg between 2000 and 10 000 years ago, and a minimum in the Early to Mid-Holocene (6000–8000 years ago).
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| 25. |
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| 26. |
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| 27. |
- Chen, L. -J, et al.
(author)
-
Electron Bulk Acceleration and Thermalization at Earth's Quasiperpendicular Bow Shock
- 2018
-
In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 120:22
-
Journal article (peer-reviewed)abstract
- Electron heating at Earth's quasiperpendicular bow shock has been surmised to be due to the combined effects of a quasistatic electric potential and scattering through wave-particle interaction. Here we report the observation of electron distribution functions indicating a new electron heating process occurring at the leading edge of the shock front. Incident solar wind electrons are accelerated parallel to the magnetic field toward downstream, reaching an electron-ion relative drift speed exceeding the electron thermal speed. The bulk acceleration is associated with an electric field pulse embedded in a whistler-mode wave. The high electron-ion relative drift is relaxed primarily through a nonlinear current-driven instability. The relaxed distributions contain a beam traveling toward the shock as a remnant of the accelerated electrons. Similar distribution functions prevail throughout the shock transition layer, suggesting that the observed acceleration and thermalization is essential to the cross-shock electron heating.
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| 28. |
- Chen, L. -J, et al.
(author)
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Electron Diffusion Regions in Magnetotail Reconnection Under Varying Guide Fields
- 2019
-
In: Geophysical Research Letters. - : Blackwell Publishing. - 0094-8276 .- 1944-8007. ; 46:12, s. 6230-6238
-
Journal article (peer-reviewed)abstract
- Kinetic structures of electron diffusion regions (EDRs) under finite guide fields in magnetotail reconnection are reported. The EDRs with guide fields 0.14–0.5 (in unit of the reconnecting component) are detected by the Magnetospheric Multiscale spacecraft. The key new features include the following: (1) cold inflowing electrons accelerated along the guide field and demagnetized at the magnetic field minimum while remaining a coherent population with a low perpendicular temperature, (2) wave fluctuations generating strong perpendicular electron flows followed by alternating parallel flows inside the reconnecting current sheet under an intermediate guide field, and (3) gyrophase bunched electrons with high parallel speeds leaving the X-line region. The normalized reconnection rates for the three EDRs range from 0.05 to 0.3. The measurements reveal that finite guide fields introduce new mechanisms to break the electron frozen-in condition.
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| 29. |
- Chen, L-J, et al.
(author)
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Lower-Hybrid Drift Waves Driving Electron Nongyrotropic Heating and Vortical Flows in a Magnetic Reconnection Layer
- 2020
-
In: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 125:2
-
Journal article (peer-reviewed)abstract
- We report measurements of lower-hybrid drift waves driving electron heating and vortical flows in an electron-scale reconnection layer under a guide field. Electrons accelerated by the electrostatic potential of the waves exhibit perpendicular and nongyrotropic heating. The vortical flows generate magnetic field perturbations comparable to the guide field magnitude. The measurements reveal a new regime of electron-wave interaction and how this interaction modifies the electron dynamics in the reconnection layer.
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| 30. |
- Davidsson, P, et al.
(author)
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Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease
- 2001
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In: Neuroscience Letters. - 0304-3940. ; 300:3, s. 157-160
-
Journal article (peer-reviewed)abstract
- The clinical significance and the effects of pharmacological treatment of patients with Alzheimer's disease (AD) were evaluated by measurement of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF). CSF-AChE of AD patients was lower, not significantly, compared with controls. However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). The increase was higher in patients treated with donezepil than in those treated with galantamine, which might be related to different mechanisms for the substances. The increase was also dose-dependent, and was especially marked in patients showing a clinical response. These data suggest that CSF biomarkers are capable not only of identifying a biochemical effect of drugs, but also of differentiating between different compounds in a dose-dependent manner.
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| 31. |
- Ergun, R. E., et al.
(author)
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Magnetic Reconnection in Three Dimensions : Modeling and Analysis of Electromagnetic Drift Waves in the Adjacent Current Sheet
- 2019
-
In: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 124:12, s. 10085-10103
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Journal article (peer-reviewed)abstract
- We present a model of electromagnetic drift waves in the current sheet adjacent to magnetic reconnection at the subsolar magnetopause. These drift waves are potentially important in governing 3-D structure of subsolar magnetic reconnection and in generating turbulence. The drift waves propagate nearly parallel to the X line and are confined to a thin current sheet. The scale size normal to the current sheet is significantly less than the ion gyroradius and can be less than or on the order of the wavelength. The waves also have a limited extent along the magnetic field (B), making them a three-dimensional eigenmode structure. In the current sheet, the background magnitudes of B and plasma density change significantly, calling for a treatment that incorporates an inhomogeneous plasma environment. Using detailed examination of Magnetospheric Multiscale observations, we find that the waves are best represented by series of electron vortices, superimposed on a primary electron drift, that propagate along the current sheet (parallel to the X line). The waves displace or corrugate the current sheet, which also potentially displaces the electron diffusion region. The model is based on fluid behavior of electrons, but ion motion must be treated kinetically. The strong electron drift along the X line is likely responsible for wave growth, similar to a lower hybrid drift instability. Contrary to a classical lower hybrid drift instability, however, the strong changes in the background B and n(o), the normal confinement to the current sheet, and the confinement along B are critical to the wave description.
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| 32. |
- Ergun, R. E., et al.
(author)
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Magnetospheric Multiscale observations of large-amplitude, parallel, electrostatic waves associated with magnetic reconnection at the magnetopause
- 2016
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In: Geophysical Research Letters. - : Blackwell Publishing. - 0094-8276 .- 1944-8007. ; 43:11, s. 5626-5634
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Journal article (peer-reviewed)abstract
- We report observations from the Magnetospheric Multiscale satellites of large-amplitude, parallel, electrostatic waves associated with magnetic reconnection at the Earth's magnetopause. The observed waves have parallel electric fields (E-||) with amplitudes on the order of 100mV/m and display nonlinear characteristics that suggest a possible net E-||. These waves are observed within the ion diffusion region and adjacent to (within several electron skin depths) the electron diffusion region. They are in or near the magnetosphere side current layer. Simulation results support that the strong electrostatic linear and nonlinear wave activities appear to be driven by a two stream instability, which is a consequence of mixing cold (<10eV) plasma in the magnetosphere with warm (similar to 100eV) plasma from the magnetosheath on a freshly reconnected magnetic field line. The frequent observation of these waves suggests that cold plasma is often present near the magnetopause.
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| 33. |
- Ergun, R. E., et al.
(author)
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Magnetospheric Multiscale Satellites Observations of Parallel Electric Fields Associated with Magnetic Reconnection
- 2016
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In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 116:23
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Journal article (peer-reviewed)abstract
- We report observations from the Magnetospheric Multiscale satellites of parallel electric fields (E-vertical bar vertical bar) associated with magnetic reconnection in the subsolar region of the Earth's magnetopause. E-vertical bar vertical bar events near the electron diffusion region have amplitudes on the order of 100 mV/m, which are significantly larger than those predicted for an antiparallel reconnection electric field. This Letter addresses specific types of E-vertical bar vertical bar events, which appear as large-amplitude, near unipolar spikes that are associated with tangled, reconnected magnetic fields. These E-vertical bar vertical bar events are primarily in or near a current layer near the separatrix and are interpreted to be double layers that may be responsible for secondary reconnection in tangled magnetic fields or flux ropes. These results are telling of the three-dimensional nature of magnetopause reconnection and indicate that magnetopause reconnection may be often patchy and/or drive turbulence along the separatrix that results in flux ropes and/or tangled magnetic fields.
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| 34. |
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| 35. |
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| 36. |
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| 37. |
- Hesse, C, et al.
(author)
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A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease
- 1999
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In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 10:6, s. 452-459
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Journal article (peer-reviewed)abstract
- Apoliprotein E (ApoE) has been implicated in the pathogenesis of Alzheimer’s disease (AD). Antibodies to ApoE label senile plaques (SP), and an interaction between ApoE and β-amyloid has been found in in vitro studies. Further, an increased frequency of the ApoE ε4 allele in AD has been reported in numerous papers. However, the pathogenetic mechanism of ApoE in AD is not known. We studied ApoE in brain tissue (hippocampus, cerebellum, frontal and temporal cortex) from patients with AD and age-matched control subjects, using both quantitative Western blotting and immunohistochemistry. In AD, a reduction of ApoE was found in the hippocampus (50% of the control value) and in the frontal cortex (52% of the control value), while no significant changes in ApoE levels were found in the temporal cortex or in the cerebellum. Also by immunohistochemistry, ApoE staining was generally decreased in AD brains, both in the neuropil and in the neuronal cellular compartments. Within the AD group, there was no significant correlation between the ApoE level and SP or neurofibrillary tangle (NFT) counts, either in the hippocampus (r = –0.14 and r = 0.55, respectively), or in the frontal cortex (r = –0.03 and r = 0.01, respectively). There were no significant differences in duration, severity of dementia, SP or NFT counts, or ApoE levels between AD patients with different numbers of ApoE ε4 alleles. After experimental brain damage in animals, marked increases in ApoE are found, probably as part of lipid recycling in neuronal and synaptic remodelling and regeneration. One may speculate whether the decrease in ApoE may suggest a disturbance in the ApoE system in AD that is unrelated to ApoE isoforms, β-amyloid deposition and NFT formation.
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| 38. |
- Hesse, C, et al.
(author)
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Measurement of apolipoprotein E (apoE) in cerebrospinal fluid
- 2000
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In: Neurochemical Research. - 1573-6903. ; 25:4, s. 511-517
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Journal article (peer-reviewed)abstract
- Apolipoprotein E (apoE) is a protein involved in transport of lipids and has been implicated to play an important role in regeneration after nerve injury. Determination of apoE in cerebrospinal fluid (CSF) thus have a potential interest when studying different forms of brain damage and as a marker of ongoing regenerative processes in the brain. However, previous studies on CSF-ApoE in Alzheimer's disease (AD) have given inconclusive results. Such inconsistent results might be related to confounding factors interfering with sample handling and/or analyses, which have not been fully elucidated. We therefore examined different potential confounding factors for analyses of apoE in CSF and also developed a new enzyme linked immunosorbent assay (ELISA). The hydrophobic character of ApoE resulted in adsorption to different types of test tubes commonly used for collection of CSF at lumbar puncture, resulting in falsely low levels. This makes CSF handling critical, especially if samples are taken in different types of tubes, or is transferred to new tubes. Taking this confounding factors in consideration and analysing patient and control CSF handled in the same way and using the new ELISA, we could confirm our previous finding of reduced levels of ApoE in AD, (3.4 +/- 1.3 mg/l) compared with controls (4.5 +/- 2.7 mg/l) (p = 0.045). Both in the AD and in the control group, higher levels of CSF-ApoE was found in individuals possessing the ApoE4 alleles. Our results support that CSF-ApoE is reduced in AD, and that handling of CSF is a critical factor, which may explain the discrepant results from previous studies. Differences in the amount of patients and controls possessing the ApoE4 allele included might also increase the variance between different studies.
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| 39. |
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| 40. |
- Hesse, M., et al.
(author)
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The predictive value of brief measures of externalizing behavior and internalizing problems in young people receiving substance use treatment : A secondary analysis
- 2023
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In: Addictive Behaviours. - : Elsevier Ltd. - 0306-4603 .- 1873-6327. ; 139
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Journal article (peer-reviewed)abstract
- Background: Identifying people at risk of poor outcomes following treatment for substance use disorders is important for developing tailored services. The aim of this study was to test whether a brief measure of internalizing and externalizing behavior could identify young adults at high risk of psychiatric care episodes and criminal offending up to four years after enrolment in treatment for substance use disorder. Methods: Clients aged 15–25 years from a randomized multicenter study were included (N = 457). At baseline, all completed the YouthMap12 screener, a measure of internalizing symptoms (IP6) and externalizing problems (EP6). We used accelerated failure time regression to assess time to psychiatric care and criminal offending, adjusting for baseline occurrence, gender, age, treatment group, and uptake area. Youden's J was used to assess optimal cut-points for risk of events. Results: The IP6 was associated with shorter time to psychiatric care following treatment enrolment (beta = −0.71, 95% confidence interval [CI] = −0.94 to −0.48; adjusted beta = −0.45, 95% CI = −0.66 to −0.25). The EP6 was associated with shorter time to criminal offending, coefficient = −0.32, 95% CI = −0.44 to −0.19; adjusted coefficient = −0.18, 95% CI = −0.30 to −0.06). Optimal cut-points were two or more for the IP6 and three or more for the EP6. Conclusions: The IP6 and the EP6, two simple and easily administered instruments, can identify young adults who are at an increased risk of future criminal offending or in need of psychiatric care. The findings lend support to using the 12-item YouthMap, as it identifies relevant risks, is compatible with local service delivery needs, and is theoretically and empirically supported. © 2022 The Author(s)
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| 41. |
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| 42. |
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| 43. |
- Koenig, Julian, et al.
(author)
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Music listening has no positive or negative effects on sleep quality of normal sleepers : Results of a randomized controlled trial
- 2013
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In: Nordic journal of music therapy. - : Informa UK Limited. - 0809-8131 .- 1944-8260. ; 22:3, s. 233-242
-
Journal article (peer-reviewed)abstract
- This paper investigates the effects of a music listening intervention on sleep quality in young participants with normal sleep. Recent studies show that relaxing classical music is an effective intervention to reduce sleep problems. The question arises, if such an intervention might have side effects on people who are not faced with sleep difficulties at first instance. We hypothesized that listening to relaxing classical music has an effect (either positive or negative) on the sleep quality of normal sleepers. To test this hypothesis we conducted a randomized control trial (RCT). Ten students (age 20 to 29 years) without sleep complaints listened to relaxing classical music at bedtime for three weeks for 45 minutes. Participants in the control group (n = 10) received no intervention. Sleep quality was measured at four times using the Pittsburg Sleep Quality Index (PSQI) before the study and weekly during the intervention period. To analyse the data, a two-way repeated measures ANOVA was calculated. Results did not reveal a statistically significant interaction between TIME and GROUP. Post-hoc comparisons showed that music listening has no influence on sleep quality at any given measuring time. However, the lack of significant effects may also be due to a type II error. Together with previous findings, we conclude that no adverse or side effects accompany the previously reported benefits of this music listening intervention. Further studies are needed to investigate the impact of music characteristics, musical preferences of participants and possible side effects of the intervention in different populations.
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| 44. |
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| 45. |
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| 46. |
- Moon, J. C., et al.
(author)
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Different initiatives across Europe to enhance losartan utilization post generics: impact and implications
- 2014
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In: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 5
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Journal article (peer-reviewed)abstract
- Introduction: There is an urgent need for health authorities across Europe to fully realize potential savings from increased use of generics to sustain their healthcare systems. A variety of strategies were used across Europe following the availability of generic losartan, the first angiotensin receptor blocker (ARB) to be approved and marketed, to enhance its prescribing vs. single-sourced drugs in the class. Demand-side strategies ranged from 100% co-payment for single-sourced ARBs in Denmark to no specific measures. We hypothesized this heterogeneity of approaches would provide opportunities to explore prescribing in a class following patent expiry. Objective: Contrast the impact of the different approaches among European countries and regions to the availability of generic losartan to provide future guidance. Methodology: Retrospective segmented regression analyses applying linear random coefficient models with country specific intercepts and slopes were used to assess the impact of the various initiatives across Europe following the availability of generic losartan. Utilization measured in defined daily doses (DDDs). Price reductions for generic losartan were also measured. Results: Utilization of losartan was over 90% of all ARBs in Denmark by the study end. Multiple measures in Sweden and one English primary care group also appreciably enhanced losartan utilization. Losartan utilization actually fell in some countries with no specific demand-side measures. Considerable differences were seen in the prices of generic losartan. Conclusion: De listing single-sourced ARBs produced the greatest increase in losartan utilization. Overall, multiple demand-side measures are needed to change physician prescribing habits to fully realize savings from generics. There is no apparent "spill over" effect from one class to another to influence future prescribing patterns even if these are closely related.
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| 47. |
- Nilsson, Anders K., 1982, et al.
(author)
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The proteome signature of cord blood plasma with high hematopoietic stem and progenitor cell count
- 2022
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In: Stem Cell Research. - : Elsevier BV. - 1873-5061. ; 61
-
Journal article (peer-reviewed)abstract
- Hematopoietic stem and progenitor cells (HSPC) from umbilical cord blood (UCB) are used for transplantation to treat blood disorders. Methods to estimate the HSPC count in umbilical cord blood, and thereby identify high-value blood units, are time-consuming and costly. Recent studies indicate that the UCB plasma protein composition relates to the HSPC count. We compared the plasma proteome of UCB with high vs low HSPC cell count (> 115 x 10(6) vs < 51 x 10(6) CD34(+) cells l(-1)) by using a combination of global untargeted MS quantitative proteomics and targeted proximity extension assay (PEA) proteomics. For the MS platform, 96 proteins differed significantly between the CD34(+) groups, and out of these, 44 proteins showed more than a two-fold difference. Seven pathways were enriched in high CD34(+) samples, including pathways relating to platelets, coagulation, and lipid transport. For the PEA platform, 61 proteins were differentially abundant, and among these 7 proteins showed more than a two-fold difference between groups. In the PEA data, a high CD34(+) cell count was associated with a protein hub with functions in platelet degranulation. We conclude that the HSPC count is related to the UCB plasma proteome, but that further studies are needed to discern if these findings reflect causal relationships.
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| 48. |
- Raulf, Alexandra, et al.
(author)
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Transgenic systems for unequivocal identification of cardiac myocyte nuclei and analysis of cardiomyocyte cell cycle status
- 2015
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In: Basic Research in Cardiology. - : Springer Science and Business Media LLC. - 0300-8428 .- 1435-1803. ; 110:3, s. 33-33
-
Journal article (peer-reviewed)abstract
- Even though the mammalian heart has been investigated for many years, there are still uncertainties in the fields of cardiac cell biology and regeneration with regard to exact fractions of cardiomyocytes (CMs) at different developmental stages, their plasticity after cardiac lesion and also their basal turnover rate. A main shortcoming is the accurate identification of CM and the demonstration of CM division. Therefore, an in vivo model taking advantage of a live reporter-based identification of CM nuclei and their cell cycle status is needed. In this technical report, we describe the generation and characterization of embryonic stem cells and transgenic mice expressing a fusion protein of human histone 2B and the red fluorescence protein mCherry under control of the CM specific alpha MHC promoter. This fluorescence label allows unequivocal identification and quantitation of CM nuclei and nuclearity in isolated cells and native tissue slices. In ventricles of adults, we determined a fraction of <20 % CMs and binucleation of 77-90 %, while in atria a CM fraction of 30 % and a binucleation index of 14 % were found. We combined this transgenic system with the CAG-eGFP-anillin transgene, which identifies cell division and established a novel screening assay for cell cycle-modifying substances in isolated, postnatal CMs. Our transgenic live reporter-based system enables reliable identification of CM nuclei and determination of CM fractions and nuclearity in heart tissue. In combination with CAG-eGFP-anillin-mice, the cell cycle status of CMs can be monitored in detail enabling screening for proliferation-inducing substances in vitro and in vivo.
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| 49. |
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| 50. |
- Toledo-Redondo, S., et al.
(author)
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Impacts of Ionospheric Ions on Magnetic Reconnection and Earth's Magnetosphere Dynamics
- 2021
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In: Reviews of geophysics. - : John Wiley & Sons. - 8755-1209 .- 1944-9208. ; 59:3
-
Research review (peer-reviewed)abstract
- Ionospheric ions (mainly H+, He+, and O+) escape from the ionosphere and populate the Earth's magnetosphere. Their thermal energies are usually low when they first escape the ionosphere, typically a few electron volt to tens of electron volt, but they are energized in their journey through the magnetosphere. The ionospheric population is variable, and it makes significant contributions to the magnetospheric mass density in key regions where magnetic reconnection is at work. Solar wind—magnetosphere coupling occurs primarily via magnetic reconnection, a key plasma process that enables transfer of mass and energy into the near-Earth space environment. Reconnection leads to the triggering of magnetospheric storms, auroras, energetic particle precipitation and a host of other magnetospheric phenomena. Several works in the last decades have attempted to statistically quantify the amount of ionospheric plasma supplied to the magnetosphere, including the two key regions where magnetic reconnection occurs: the dayside magnetopause and the magnetotail. Recent in situ observations by the Magnetospheric Multiscale spacecraft and associated modeling have advanced our current understanding of how ionospheric ions alter the magnetic reconnection process, including its onset and efficiency. This article compiles the current understanding of the ionospheric plasma supply to the magnetosphere. It reviews both the quantification of these sources and their effects on the process of magnetic reconnection. It also provides a global description of how the ionospheric ion contribution modifies the way the solar wind couples to the Earth's magnetosphere and how these ions modify the global dynamics of the near-Earth space environment.Plain Language SummaryAbove the neutral atmosphere, space is filled with charged particles, which are tied to the Earth's magnetic field. The particles come from two sources, the solar wind and the Earth's upper atmosphere. Most of the solar wind particles are deflected by the Earth´s magnetic field, but some can penetrate into near-Earth space. The ionized layer of the upper atmosphere is continuously ejecting particles into space, which have low energies and are difficult to measure. We investigate the relative importance of the two charged particle sources for the dynamics of plasma processes in near-Earth space. In particular, we consider the effects of these sources in magnetic reconnection. Magnetic reconnection allows initially separated plasma regions to become magnetically connected and mix, and converts magnetic energy to kinetic energy of charged particles. Magnetic reconnection is the main driver of geomagnetic activity in the near-Earth space, and is responsible for the release of energy that drives a variety of space weather effects. We highlight the fact that plasma from the ionized upper atmosphere contributes a significant part of the density in the key regions where magnetic reconnection is at work, and that this contribution is larger when the geomagnetic activity is high.
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