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- Galt, Sheila, 1956, et al.
(author)
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EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS
- 1993
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In: Bioelectromagnetics. - : Wiley. - 1521-186X .- 0197-8462. ; 14:4, s. 315-327
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Journal article (peer-reviewed)abstract
- The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied. (C) 1993 Wiley-Liss, Inc.
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