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- Waligórski, M P R, et al.
(author)
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A simple track structure model of ion beam radiotherapy.
- 2006
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In: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 122:1-4, s. 471-4
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Journal article (peer-reviewed)abstract
- A simple radiotherapy ion beam calculation based on the cellular track structure model, using in vitro cell survival parameters fitted from recent experimental data, is presented. The calculation represents a single-fraction ion exposure (roughly corresponding to a 2 Gy fraction of megavolt X rays) and exploits concepts used in clinical radiotherapy, such as entrance, or 'skin' ion dose. The depth distribution of cells surviving their irradiation by a beam of 385 MeV amu(-1) carbon ions is calculated over the range of the stopping ions, as a sequence of track-segments, in the continuous slowing-down approximation. An interpretation of the 'clinical relative biological effectiveness' concept is suggested.
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| 4. |
- Hollmark, M, 1975-, et al.
(author)
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Influence of multiple scattering and energy loss straggling on the absorbed dose distributions of therapeutic light ion beams : I. Analytical pencil beam model.
- 2004
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In: Phys Med Biol. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 49:14, s. 3247-3265
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Journal article (other academic/artistic)abstract
- The lateral and longitudinal distributions of absorbed dose of broad and narrowlight ion beams in water are investigated. An analytical algorithm based on thegeneralized Fermi–Eyges theory is developed and used to calculate the effectsof multiple scattering and range straggling on the dose distribution of light ionbeams in water. A first-order Gaussian multiple scattering and energy lossstraggling approach is generally sufficiently accurate for describing the lateraland longitudinal spread of the Bragg peak and the associated energy depositiondistribution of therapeutic light ion beams at ranges of clinical interest. Nuclearreactions are not taken into account in this study. The analytical algorithmgiven in the present study allows an accurate description of the radial spreadand the range straggling of light ions traversing matter. A verification of thisapproach by comparing with experimental data, Monte Carlo methods andother analytical techniques will be presented in a forthcoming paper.
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