SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Holm Mathias) "

Search: WFRF:(Holm Mathias)

  • Result 1-50 of 162
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Kirkeleit, Jorunn, et al. (author)
  • Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population
  • 2023
  • In: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 66
  • Journal article (peer-reviewed)abstract
    • Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. Funding: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.
  •  
2.
  • Sköldberg, Håkan, et al. (author)
  • BIO-CCS I FJÄRRVÄRMESEKTORN – SYNTES
  • 2022
  • Reports (other academic/artistic)abstract
    • Den svenska fjärrvärmesektorn har stor potential att bidra med negativa koldioxidutsläpp genom bio-CCS, minst 10 Mton per år. Den största osäkerheten beträffande möjligheterna för bio-CCS gäller marknads förutsättningarna. Uppvärmningsbranschen har en vision om att år 2045 utgöra en kolsänka. Ett sätt att åstadkomma detta är genom att avskilja och lagra koldioxidutsläpp med biogent ursprung. Ett antal fjärrvärmeföretag har redan olika långt gångna planer på att satsa på bio-CCS. De har sett ett värde i att samarbeta kring hur detta kan åstadkommas. Ett led i detta är projektet Bio-CCS i fjärrvärmesektorn som består av ett gediget underlag baserat på forskning kring olika aspekter av frågan samt en strategi baserad på det underlaget. I denna rapport redovisas en syntes av detta forskningsarbete. Projektet visar att fjärrvärmesektorn har stor teoretisk potential att bidra med negativa koldioxidutsläpp, minst 10 Mton per år. I huvudsak är avskiljning, transport och lagring av koldioxid beprövad teknik även om tillämpningen i detta fall är ny. Även om bio-CCS är förknippad med energianvändning så bidrar tekniken sett ur ett systemperspektiv med stor nytta för att minska koldioxid[1]utsläppen. Bio-CCS är en relativt dyr teknik och det är angeläget att utnyttja samverkan och kluster för att exempelvis skapa ökad kostnadseffektivitet i transport och mellanlagring. Tillgång till lagringsplatser är en förutsättning för framgång och flera alternativ bedöms bli tillgängliga. Det kan dock uppstå konkurrens om tillgången till lagringsplatserna. De regelmässiga förutsättningarna för bio-CCS i Sverige har förbättrats avsevärt de senaste dryga decenniet. Flera regelmässiga hinder kvarstår dock. En del utgör mindre barriärer, andra är av mer betydande karaktär. Den största osäkerheten beträffande möjligheterna för bio-CCS gäller ekonomin. Flera potentiella finansieringsmetoder har studerats, både stöd, regleringar och frivilligmarknader. Det finns fortfarande oklarheter kring syftet med planerade stöd och det framtida ägandet av de negativa utsläppen. Det genomförda projektet har skapat ett forum för kunskapsuppbyggnad, erfarenhetsutbyte och nätverkande, vilket de deltagande företagen bedömt vara mycket värdefullt.
  •  
3.
  • Wan, Y., et al. (author)
  • First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo
  • 2004
  • In: J Med Chem. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 47:6, s. 1536-1546
  • Journal article (peer-reviewed)abstract
    • In this investigation, it is demonstrated that the first nonpeptide AT(1) receptor agonist L-162,313 (1), disclosed in 1994, also acts as an agonist at the AT(2) receptor. In anesthetized rats, administration of compound 1 intravenously or locally in the duodenum increased duodenal mucosal alkaline secretion, effects that were sensitive to the selective AT(2) receptor antagonist PD-123,319. The data strongly suggest that 1 is an AT(2) receptor agonist in vivo. To the best of our knowledge, this substance is the first nonpeptidic low-molecular weight compound with an agonistic effect mediated through the AT(2) receptor.
  •  
4.
  • Abelev, Betty, et al. (author)
  • Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
  • 2013
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
  • Journal article (peer-reviewed)abstract
    • Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
  •  
5.
  • Abelev, Betty, et al. (author)
  • Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
  • 2012
  • In: Journal of High Energy Physics. - 1029-8479. ; :11
  • Journal article (peer-reviewed)abstract
    • The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
  •  
6.
  • Abelev, Betty, et al. (author)
  • Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
  • 2012
  • In: Journal of High Energy Physics. - 1029-8479. ; :7
  • Journal article (peer-reviewed)abstract
    • We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
  •  
7.
  • Accordini, S., et al. (author)
  • A three-generation study on the association of tobacco smoking with asthma
  • 2018
  • In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 47:4, s. 1106-1117
  • Journal article (peer-reviewed)abstract
    • Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged <= 51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
  •  
8.
  • Accordini, S., et al. (author)
  • Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach
  • 2021
  • In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 58:4
  • Journal article (peer-reviewed)abstract
    • Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very limited. We investigated multigeneration causal associations to estimate the causal effects of tobacco smoking on lung function within the paternal line. We analysed data from 383 adult offspring (age 18-47 years; 52.0% female) and their 274 fathers, who had participated in the European Community Respiratory Health Survey (ECRHS)/Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study and had provided valid measures of pre-bronchodilator lung function. Two counterfactual-based, multilevel mediation models were developed with: paternal grandmothers' smoking in pregnancy and fathers' smoking initiation in prepuberty as exposures; fathers' forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), or FEV1/FVC z-scores as potential mediators (proxies of unobserved biological mechanisms that are true mediators); and offspring's FEV1 and FVC, or FEV1/FVC z-scores as outcomes. All effects were summarised as differences (Delta) in expected z-scores related to fathers' and grandmothers' smoking history. Fathers' smoking initiation in prepuberty had a negative direct effect on both offspring's FEV1 (Delta z-score -0.36, 95% CI -0.63--0.10) and FVC (-0.50, 95% CI -0.80--0.20) compared with fathers' never smoking. Paternal grandmothers' smoking in pregnancy had a negative direct effect on fathers' FEV1/FVC -0.57, 95% CI -1.09--0.05) and a negative indirect effect on offspring's FEV1/FVC (-0.12, 95% CI -0.21--0.03) compared with grandmothers' not smoking before fathers' birth nor during fathers' childhood. Fathers' smoking in prepuberty and paternal grandmothers' smoking in pregnancy may cause lower lung function in offspring. Our results support the concept that lifestyle-related exposures during these susceptibility periods influence the health of future generations.
  •  
9.
  • Almquist, Martin, et al. (author)
  • Kloka kliniska val – att avstå det som inte gör nytta för patienten : [Choosing Wisely in Sweden]
  • 2023
  • In: Läkartidningen. - : Sveriges Läkarförbund. - 0023-7205 .- 1652-7518. ; 120
  • Research review (peer-reviewed)abstract
    • Overdiagnosis and overtreatment receive increasing attention. More than 20 percent of health expenditure is without patient benefit, so-called low-value care. Several national and international initiatives have been launched to minimize low-value care. Arguably, the most widely spread initiative is Choosing Wisely. First launched by the American Board of Internal Medicine in 2012, this campaign has spread to more than 20 countries. The Swedish Society of Medicine has identified low-value care as a significant problem in Swedish health care and  has established a working group to investigate if and how a campaign based on Choosing Wisely would be feasible in Sweden. Here, the working group reports on the history of Choosing Wisely, identifies potential challenges for deimplementation generally and in the Swedish context specifically.
  •  
10.
  • Amid Hägg, Shadi, et al. (author)
  • Smokers with insomnia symptoms are less likely to stop smoking
  • 2020
  • In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 170
  • Journal article (peer-reviewed)abstract
    • Objectives: Smoking is associated with sleep disturbances. The aim of this study was to analyze whether sleep disturbances are predictors of smoking cessation and whether continued smoking is associated with the development of sleep disturbances. Methods: A questionnaire was sent to randomly selected men and women in Northern Europe in 1999-2001 (RHINE II) and was followed up by a questionnaire in 2010-2012 (RHINE III). The study population consisted of 2568 participants who were smokers at baseline and provided data on smoking at follow-up. Insomnia symptoms were defined as having difficulty initiating and/or maintaining sleep and/or early morning awakening >= 3 nights/week. Multiple logistic regression analyses were performed to calculate odds ratios (OR). Results: Subjects with difficulty initiating sleep (adjusted odds ratio; 95% confidence interval: 0.6; 0.4-0.8), difficulty maintaining sleep (0.7; 0.5-0.9), early morning awakening (0.6; 0.4-0.8), any insomnia symptom (0.6; 0.5-0.8) or excessive daytime sleepiness (0.7; 0.5-0.8) were less likely to achieve long-term smoking cessation after adjustment for age, BMI, pack-years, hypertension, diabetes, chronic bronchitis, rhinitis, asthma, gender and BMI difference. There was no significant association between snoring and smoking cessation. In subjects without sleep disturbance at baseline, continued smoking increased the risk of developing difficulty initiating sleep during the follow-up period compared with those that had quit smoking (adj. OR 1.7, 95% CI 1.2-2.3). Conclusions: Insomnia symptoms and excessive daytime sleepiness negatively predict smoking cessation. Smoking is a risk factor for the development of difficulty initiating sleep. Treatment for sleep disturbances should be included in smoking-cessation programs.
  •  
11.
  • Amin, H., et al. (author)
  • Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants
  • 2023
  • In: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 57:32, s. 11750-11766
  • Journal article (peer-reviewed)abstract
    • Minimal research exists onthe factors influencing the indoorbacterial community. Despite their proposed importance for health,here we report environmental factors influencing the composition ofthe indoor bacterial communities. Airborne bacteria and endotoxin may affect asthma andallergies.However, there is limited understanding of the environmental determinantsthat influence them. This study investigated the airborne microbiomesin the homes of 1038 participants from five cities in Northern Europe:Aarhus, Bergen, Reykjavik, Tartu, and Uppsala. Airborne dust particleswere sampled with electrostatic dust fall collectors (EDCs) from theparticipants' bedrooms. The dust washed from the EDCs'clothes was used to extract DNA and endotoxin. The DNA extracts wereused for quantitative polymerase chain (qPCR) measurement and 16SrRNA gene sequencing, while endotoxin was measured using the kineticchromogenic limulus amoebocyte lysate (LAL) assay. The results showedthat households in Tartu and Aarhus had a higher bacterial load anddiversity than those in Bergen and Reykjavik, possibly due to elevatedconcentrations of outdoor bacterial taxa associated with low precipitationand high wind speeds. Bergen-Tartu had the highest difference (ANOSIM R = 0.203) in & beta; diversity. Multivariate regressionmodels showed that & alpha; diversity indices and bacterial and endotoxinloads were positively associated with the occupants' age, numberof occupants, cleaning frequency, presence of dogs, and age of thehouse. Further studies are needed to understand how meteorologicalfactors influence the indoor bacterial community in light of climatechange.
  •  
12.
  • Assimes, Themistocles L., et al. (author)
  • Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
  • 2010
  • In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
  • Journal article (peer-reviewed)abstract
    • Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
  •  
13.
  • Bake, Björn, 1939, et al. (author)
  • Exhaled Particles After a Standardized Breathing Maneuver
  • 2017
  • In: Journal of Aerosol Medicine and Pulmonary Drug Delivery. - : Mary Ann Liebert Inc. - 1941-2711 .- 1941-2703. ; 30:4, s. 267-273
  • Journal article (peer-reviewed)abstract
    • Background: Particles in exhaled air (PEx) provide samples of respiratory tract lining fluid from small airways and offer a new opportunity to monitor pathological changes. The exhaled particles are produced by reopening of closed small airways and contain surfactant. The amount of PEx varies by orders of magnitude among subjects. A standardized breathing pattern reduces the variation, but it remains large and the reasons are unknown. The aim of the present study was to assess to what extent sex, age, body size, and spirometry results explain the interindividual variation of PEx among healthy middle-aged subjects. Methods: The PExA((R)) instrument was used to measure PEx in 126 healthy middle-aged nonsmoking subjects participating in the European Respiratory Community Health Survey (ERCS-III). The subjects performed a standardized breathing maneuver involving expiration to residual volume, a breath-hold of 3 seconds, a full inspiration, and then a full expiration into the PExA instrument. PEx number concentrations were expressed per exhalation and per exhaled liter. Age and anthropometric and spirometric variables were analyzed as potential predictors. Results: PEx/L was consistently and negatively associated to lung size-related variables and accordingly lower in men than in women. PEx/Exhalation was similar in women and men. Increasing age was associated with increasing PEx. Reference equations are presented based on age, weight, and spirometry variables and independent of sex. These predictors explained 28%-29% of the interindividual variation. Conclusions: The interindividual variation of PEx after a standardized breathing maneuver is large and the considered predictors explain a minor part only.
  •  
14.
  • Bengtsson, Caroline, et al. (author)
  • Incident chronic rhinosinusitis is associated with impaired sleep quality: Results of the RhiNE study
  • 2019
  • In: Journal of Clinical Sleep Medicine. - : American Academy of Sleep Medicine (AASM). - 1550-9389 .- 1550-9397. ; 15:6, s. 899-905
  • Journal article (peer-reviewed)abstract
    • Study Objectives: Chronic rhinosinusitis (CRS) is a common inflammatory disease of the nasal cavity and paranasal sinuses. Associations between CRS and poor sleep quality have been reported. This 10-year follow-up study investigates possible associations between incident CRS and sleep quality. Methods: A questionnaire was sent to 16,500 individuals in Sweden, Norway, Denmark, Iceland and Estonia in 2000. It included questions on airway diseases, age, sex, body mass index, smoking habits, comorbidities, education and sleep quality. In 2010, a second questionnaire was sent to the same individuals, with a response rate of 53%. A subgroup of 5,145 individuals without nasal symptoms in 2000 was studied. Multiple logistic regression was performed to examine associations between CRS (defined according to the European position paper on rhinosinusitis and nasal polyps epidemiological criteria) at follow-up and sleep quality, with adjustment for potential confounders. Individuals with the respective sleep problem at baseline were excluded. Results: Over 10 years, 141 (2.7%) of the individuals without nasal symptoms in 2000 had developed CRS. CRS was associated with difficulties inducing sleep (adjusted odds ratio 2.81 [95% CI 1.67–4.70]), difficulties maintaining sleep (2.07 [1.35–3.18]), early morning awakening (3.03 [1.91–4.81]), insomnia (2.21 [1.46–3.35]), excessive daytime sleepiness (2.85 [1.79–4.55]), and snoring (3.31 [2.07–5.31]). Three insomnia symptoms at baseline increased the risk of CRS at follow-up by 5.00 (1.93–12.99). Conclusions: Incident CRS is associated with impaired sleep quality and excessive daytime sleepiness. Insomnia symptoms may be a risk factor for the development of CRS. © 2019 American Academy of Sleep Medicine. All rights reserved.
  •  
15.
  • Blom, Hans, et al. (author)
  • Parallel Flow Measurements in Microstructures by Use of a Multifocal 4 x 1 Diffractive Optical Fan-Out Element
  • 2002
  • In: Applied Optics. - 1559-128X .- 2155-3165. ; 41:31, s. 6614-6620
  • Journal article (peer-reviewed)abstract
    • We have developed a multifocal optical fluorescence correlation spectroscopy system for parallel flow analyses. Multifocal excitation was made possible through a 4 x 1 diffractive optical fan-out element, which produces uniform intensity in all four foci. Autocorrelation flow analyses inside a 20 μm x 20 μm square microchannel, with the 4 x 1 fan-out foci perpendicular to the flow direction, made it possible to monitor different flows in all four foci simultaneously. We were able to perform cross-correlation flow analyses by turning the microstructure, thereby having all four foci parallel to the direction of flow. Transport effects of the diffusion as a function of flow and distance could then also be studied.
  •  
16.
  • Buschle, Markus, et al. (author)
  • A tool for automatic enterprise architecture modeling
  • 2011
  • In: Proceedings of the CAiSE Forum 2011. ; , s. 25-32
  • Conference paper (peer-reviewed)abstract
    • Enterprise architecture is an approach which aim to provide decision support based on organization-wide models. The creation of these models is however cumbersome as multiple aspects of an organization need to be considered. The Enterprise Architecture approach would be significantly less demanding if data used to create the models could be collected automatically. This paper illustrates how a vulnerability scanner can be utilized for data collection in order to automatically create enterprise architecture models. We show how this approach can be realized by extending an earlier presented Enterprise Architecture tool. An example is provided through a case study applying the tool on a real network.
  •  
17.
  • Buschle, Markus, et al. (author)
  • A Tool for automatic Enterprise Architecture modeling
  • 2012
  • In: IS Olympics. - Cham : Springer. - 9783642297489 ; , s. 1-15
  • Conference paper (peer-reviewed)abstract
    • Enterprise Architecture is an approach which aims to provide decision support based on organization-wide models. The creation of these models is however cumbersome as multiple aspects of an organization need to be considered. The Enterprise Architecture approach would be significantly less demanding if data used to create the models could be collected automatically. This paper illustrates how a vulnerability scanner can be utilized for data collection in order to automatically create Enterprise Architecture models, especially covering infrastructure aspects. We show how this approach can be realized by extending an earlier presented Enterprise Architecture tool. An example is provided through a case study applying the tool on a real network.
  •  
18.
  • Carlsen, Hanne Krage, et al. (author)
  • Indicators of residential traffic exposure: Modelled NOX, traffic proximity, and self-reported exposure in RHINE III
  • 2017
  • In: Atmospheric Environment. - : Elsevier BV. - 1352-2310 .- 1873-2844. ; 167, s. 416-425
  • Journal article (peer-reviewed)abstract
    • Few studies have investigated associations between self-reported and modelled exposure to traffic pollution. The objective of this study was to examine correlations between self-reported traffic exposure and modelled (a) NOX and (b) traffic proximity in seven different northern European cities; Aarhus (Denmark), Bergen (Norway), Gothenburg, Umeå, and Uppsala (Sweden), Reykjavik (Iceland), and Tartu (Estonia). We analysed data from the RHINE III (Respiratory Health in Northern Europe, www.rhine.nu) cohorts of the seven study cities. Traffic proximity (distance to the nearest road with >10,000 vehicles per day) was calculated and vehicle exhaust (NOX) was modelled using dispersion models and land-use regression (LUR) data from 2011. Participants were asked a question about self-reported traffic intensity near bedroom window and another about traffic noise exposure at the residence. The data were analysed using rank correlation (Kendall's tau) and inter-rater agreement (Cohen's Kappa) between tertiles of modelled NOX and traffic proximity tertile and traffic proximity categories (0–150 metres (m), 150–200 m, >300 m) in each centre. Data on variables of interest were available for 50–99% of study participants per each cohort. Mean modelled NOX levels were between 6.5 and 16.0 μg/m3; median traffic intensity was between 303 and 10,750 m in each centre. In each centre, 7.7–18.7% of respondents reported exposure to high traffic intensity and 3.6–16.3% of respondents reported high exposure to traffic noise. Self-reported residential traffic exposure had low or no correlation with modelled exposure and traffic proximity in all centres, although results were statistically significant (tau = 0.057–0.305). Self-reported residential traffic noise correlated weakly (tau = 0.090–0.255), with modelled exposure in all centres except Reykjavik. Modelled NOX had the highest correlations between self-reported and modelled traffic exposure in five of seven centres, traffic noise exposure had the highest correlation with traffic proximity in tertiles in three centres. Self-reported exposure to high traffic intensity and traffic noise at each participant's residence had low or weak although statistically significant correlations with modelled vehicle exhaust pollution levels and traffic proximity. © 2017
  •  
19.
  • Carlsson, Linnea, et al. (author)
  • Ever Smoking is Not Associated with Performed Spirometry while Occupational Exposure and Respiratory Symptoms are
  • 2023
  • In: International Journal of COPD. - 1176-9106. ; 18, s. 341-348
  • Journal article (peer-reviewed)abstract
    • Objective: Despite recommendations, assessment using spirometry or peak expiratory flow is insufficient in the clinical evaluation of suspected obstructive pulmonary disease. The aim was to investigate factors associated with performing spirometry or peak flow expiratory flow assessment. Methods: Randomly selected subjects from the general population aged 50–65 completed a respiratory questionnaire with items about the history of previously performed spirometry or peak expiratory flow. The association between ever having had spirometry or peak expiratory flow performed was analyzed for smoking, age, sex, occupational exposures, dyspnea, wheeze, self-reported physician diagnosed asthma and COPD using multivariable logistic regression models. The results are presented as odds ratios (OR) with 95% confidence intervals (95% CIs). Results: Of the 1105 participants, 43.4% (n=479) had a history of previously performed spirometry or peak expiratory flow. Occupational exposure (OR 1.72, [95% CI] 1.30–2.27), wheeze (OR 2.29, 1.41–3.70), and dyspnea (OR 1.70, 1.11–2.60) were associated with previously performed spirometry. Compared to men, women had spirometry or peak expiratory flow performed less often (OR 0.67, 0.51–0.86). Neither current smoking (OR 0.83, 0.57–1.20) or former smoking (OR 1.27, 0.96–1.67) were associated with performed spirometry or peak expiratory flow. Conclusion: We found no relation between smoking status and a history of previously performed spirometry or peak expiratory flow in a population-based sample of middle-aged people. This is surprising regarding the strong guidelines which highlight the importance for spirometry surveillance on current smokers due to their increased risk of lung disease. Male sex, respiratory symptoms and occupational exposures to air pollution were associated with previously performed spirometry or peak expiratory flow. The association with occupational exposure may be an effect of pre-employment screening and workplace surveillance, and the findings indicate that females do not receive the same attention regarding spirometry or peak expiratory flow.
  •  
20.
  • Christensen, Stine Holmegaard, et al. (author)
  • A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe
  • 2016
  • In: European clinical respiratory journal. - : Informa UK Limited. - 2001-8525. ; 3
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood.METHODS: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945-1973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models.RESULTS: Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54-0.85] and nasal symptoms (OR 0.82, 0.68-0.99) than city upbringing, and an urban-rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88-0.94). Pets in the home at birth (OR 0.78, 0.68-0.88) and during childhood (OR 0.83, 0.74-0.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing.CONCLUSION: Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban-rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings.
  •  
21.
  • del Río, Miren, et al. (author)
  • Emerging stability of forest productivity by mixing two species buffers temperature destabilizing effect
  • 2022
  • In: Journal of Applied Ecology. - : John Wiley & Sons. - 0021-8901 .- 1365-2664. ; 59:11, s. 2730-2741
  • Journal article (peer-reviewed)abstract
    • The increasing disturbances in monocultures around the world are testimony to their instability under global change. Many studies have claimed that temporal stability of productivity increases with species richness, although the ecological fundamentals have mainly been investigated through diversity experiments. To adequately manage forest ecosystems, it is necessary to have a comprehensive understanding of the effect of mixing species on the temporal stability of productivity and the way in which it is influenced by climate conditions across large geographical areas. Here, we used a unique dataset of 261 stands combining pure and two-species mixtures of four relevant tree species over a wide range of climate conditions in Europe to examine the effect of species mixing on the level and temporal stability of productivity. Structural equation modelling was employed to further explore the direct and indirect influence of climate, overyielding, species asynchrony and additive effect (i.e. temporal stability expected from the species growth in monospecific stands) on temporal stability in mixed forests. We showed that by adding only one tree species to monocultures, the level (overyielding: +6%) and stability (temporal stability: +12%) of stand growth increased significantly. We identified the key effect of temperature on destabilizing stand growth, which may be mitigated by mixing species. We further confirmed asynchrony as the main driver of temporal stability in mixed stands, through both the additive effect and species interactions, which modify between-species asynchrony in mixtures in comparison to monocultures. Synthesis and applications. This study highlights the emergent properties associated with mixing two species, which result in resource efficient and temporally stable production systems. We reveal the negative impact of mean temperature on temporal stability of forest productivity and how the stabilizing effect of mixing two species can counterbalance this impact. The overyielding and temporal stability of growth addressed in this paper are essential for ecosystem services closely linked with the level and rhythm of forest growth. Our results underline that mixing two species can be a realistic and effective nature-based climate solution, which could contribute towards meeting EU climate target policies.
  •  
22.
  • Ekbom, Emil, et al. (author)
  • Asthma and treatment with inhaled corticosteroids: associations with hospitalisations with pneumonia
  • 2019
  • In: Bmc Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 19:1
  • Journal article (peer-reviewed)abstract
    • Background: Pneumonia is an important cause of morbidity and mortality. COPD patients using inhaled corticosteroids (ICS) have an increased risk of pneumonia, but less is known about whether ICS treatment in asthma also increases the risk of pneumonia. The aim of this analysis was to examine risk factors for hospitalisations with pneumonia in a general population sample with special emphasis on asthma and the use of ICS in asthmatics. Methods: In 1999 to 2000, 7340 subjects aged 28 to 54 years from three Swedish centres completed a brief health questionnaire. This was linked to information on hospitalisations with pneumonia from 2000 to 2010 and treatment with ICS from 2005 to 2010 held within the Swedish National Patient Register and the Swedish Prescribed Drug Register. Results: Participants with asthma (n = 587) were more likely to be hospitalised with pneumonia than participants without asthma (Hazard Ratio (HR 3.35 (1.97-5.02)). Other risk factors for pneumonia were smoking (HR 1.93 (1.22-3.06)), BMI < 20 kg/m(2) (HR 2.74 (1.41-5.36)) or BMI > 30 kg/m(2) (HR 2.54 (1.39-4.67)). Asthmatics (n = 586) taking continuous treatment with fluticasone propionate were at an increased risk of being hospitalized with pneumonia (incidence risk ratio (IRR) 7.92 (2.32-27.0) compared to asthmatics that had not used fluticasone propionate, whereas no significant association was found with the use of budesonide (IRR 1.23 (0.36-4.20)). Conclusion: Having asthma is associated with a three times higher risk of being hospitalised for pneumonia. This analysis also indicates that there are intraclass differences between ICS compounds with respect to pneumonia risk, with an increased risk of pneumonia related to fluticasone propionate.
  •  
23.
  • Ekström, Magnus, et al. (author)
  • Breathlessness across generations : results from the RHINESSA generation study
  • 2022
  • In: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 77:2, s. 172-177
  • Journal article (peer-reviewed)abstract
    • Background: Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations.Methods: We analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings.Results: A total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring.Conclusion: Parents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.
  •  
24.
  • Ewert, Sara, 1974, et al. (author)
  • Dynamic expression of the angiotensin II type 2 receptor and duodenal mucosal alkaline secretion in the Sprague-Dawley rat
  • 2006
  • In: Experimental Physiology. - : Wiley. - 0958-0670. ; 91:1, s. 191-199
  • Journal article (peer-reviewed)abstract
    • Activation of angiotensin II type 2 receptors (AT2R) has been shown to stimulate duodenal mucosal alkaline secretion (DMAS) in Sprague-Dawley rats (S-D). This finding could not be confirmed in another line of S-D, and the present study investigates whether the level of AT2R expression determines the response to the AT2R agonist CGP42112A. DMAS was measured in anaesthetized rats using in situ pH-stat titration. Real-time PCR and Western blot were used to assess AT1R and AT2R RNA and protein expression, respectively. CGP42112A (0.1 microg kg(-1)min(-1) I.V.) elicited a 45% net increase in DMAS in the previous S-D line studied, whereas no change occurred in the new S-D line. Luminal administration of prostaglandin E2 (10(-5) M) increased DMAS similarly in both S-D lines. AT2R protein expression was significantly higher in tissue from the previous line compared to the new line. Individual AT1R to AT2R ratios (RNA and protein) were significantly higher in the new line compared to the previous S-D line. In the new S-D line intravenous infusion of angiotensin II (Ang II; 10 microg kg(-1) h(-1)) over 120 min significantly lowered the duodenal AT1aR to AT2R RNA ratio. Prolonged Ang II infusion over 240 min increased AT2R protein expression and evoked a 42% stimulatory response in DMAS to CGP42112A. The level of local AT2R expression determines the effect of the AT2R agonist CGP42112A on rat duodenal mucosal alkaline secretion. AT2R expression should be confirmed before interpreting the experimental effects of pharmacological interferences with this receptor.
  •  
25.
  • Ewert, Sara, 1974, et al. (author)
  • The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion.
  • 2003
  • In: BMC physiology. - 1472-6793. ; 3
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: This study investigates bradykinin and nitric oxide as potential mediators of AT2-receptor-stimulated duodenal mucosal alkaline secretion. Duodenal mucosal alkaline secretion was measured in methohexital- and alpha-chloralose-anaesthetised rats by means of in situ pH-stat titration. Immunohistochemistry and Western blot were used to identify the BK2 receptors. RESULTS: The AT2 receptor agonist CGP42112A (0.1 microg kg(-1) min(-1)) administered intravenously increased the duodenal mucosal alkaline secretion by approximately 50 %. This increase was sensitive to the selective BK2 receptor blocker HOE140 (100 ng/kg i.v.), but not to luminal administration of the NOS blocker L-NAME (0.3 mM). Mean arterial pressure did not differ between groups during the procedures. Immunohistochemistry showed a distinct staining of the crypt epithelium and a moderate staining of basal cytoplasm in villus enterocytes. CONCLUSION: The results suggest that the AT2-receptor-stimulated alkaline secretion is mediated via BK2 receptors located in the duodenal cryptal mucosal epithelium.
  •  
26.
  • Flexeder, Claudia, et al. (author)
  • Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey
  • 2019
  • In: Respiratory Research. - : BioMed Central. - 1465-9921 .- 1465-993X. ; 20
  • Journal article (peer-reviewed)abstract
    • Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years. We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Associations of SHS exposure with respiratory health (asthma symptom score, asthma, chronic bronchitis, COPD) were analysed using generalised linear mixed-effects models adjusted for confounding factors (including sex, age, smoking status, socioeconomic status and allergic sensitisation). Linear mixed-effects models with additional adjustment for height were used to assess the relationships between SHS exposure and lung function levels and decline. Reported exposure to SHS decreased in all 26 study centres over time. The prevalence of SHS exposure was 38.7% at baseline (1990-1994) and 7.1% after the 20-year follow-up (2008-2011). On average 2.4% of the study participants were not exposed at the first, but were exposed at the third examination. An increase in SHS exposure over time was associated with doctor-diagnosed asthma (odds ratio (OR): 2.7; 95% confidence interval (95%-CI): 1.2-5.9), chronic bronchitis (OR: 4.8; 95%-CI: 1.6-15.0), asthma symptom score (count ratio (CR): 1.9; 95%-CI: 1.2-2.9) and dyspnoea (OR: 2.7; 95%-CI: 1.1-6.7) compared to never exposed to SHS. Associations between increase in SHS exposure and incidence of COPD (OR: 2.0; 95%-CI: 0.6-6.0) or lung function (beta: - 49 ml; 95%-CI: -132, 35 for FEV1 and beta: - 62 ml; 95%-CI: -165, 40 for FVC) were not apparent. Exposure to second-hand smoke may lead to respiratory symptoms, but this is not accompanied by lung function changes.
  •  
27.
  • Fuertes, Elaine, et al. (author)
  • Leisure-time vigorous physical activity is associated with better lung function : the prospective ECRHS study
  • 2018
  • In: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 73:4, s. 376-384
  • Journal article (peer-reviewed)abstract
    • Objective: We assessed associations between physical activity and lung function, and its decline, in the prospective population-based European Community Respiratory Health Survey cohort. Methods: FEV1 and FVC were measured in 3912 participants at 27-57 years and 39-67 years (mean time between examinations= 11.1 years). Physical activity frequency and duration were assessed using questionnaires and used to identify active individuals (physical activity >= 2 times and >= 1 hour per week) at each examination. Adjusted mixed linear regression models assessed associations of regular physical activity with FEV1 and FVC. Results: Physical activity frequency and duration increased over the study period. In adjusted models, active individuals at the first examination had higher FEV1 (43.6 mL (95% CI 12.0 to 75.1)) and FVC (53.9 mL (95% CI 17.8 to 89.9)) at both examinations than their non-active counterparts. These associations appeared restricted to current smokers. In the whole population, FEV1 and FVC were higher among those who changed from inactive to active during the follow-up (38.0 mL (95% CI 15.8 to 60.3) and 54.2 mL (95% CI 25.1 to 83.3), respectively) and who were consistently active, compared with those consistently non-active. No associations were found for lung function decline. Conclusion: Leisure-time vigorous physical activity was associated with higher FEV1 and FVC over a 10-year period among current smokers, but not with FEV1 and FVC decline.
  •  
28.
  • Fuertes, Elaine, et al. (author)
  • Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study
  • 2018
  • In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 120, s. 364-372
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas.OBJECTIVE: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 μm (PM2.5) and <10 μm (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey.METHODS: Associations between repeated assessments (at 27-57 and 39-67 years) of being physically active (physical activity: ≥2 times and ≥1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never- and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (≤75th percentile (low/medium) versus >75th percentile (high)).RESULTS: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03).CONCLUSIONS: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.
  •  
29.
  • Gorski, Mathias, et al. (author)
  • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
  • 2022
  • In: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 102:3, s. 624-639
  • Journal article (peer-reviewed)abstract
    • Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genomewide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR- baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant- by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with agedependency of genetic cross- section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in- silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03- 1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.
  •  
30.
  • Gyawali, S., et al. (author)
  • Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe
  • 2023
  • In: Frontiers in Allergy. - : Frontiers Media S.A.. - 2673-6101. ; 4
  • Journal article (peer-reviewed)abstract
    • BackgroundGiven the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.ObjectiveThis study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.MethodsWe included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.ResultsOf 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05-1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29-2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76-1.32) in offspring was observed.ConclusionResults from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.
  •  
31.
  • Gyawali, S., et al. (author)
  • Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study
  • 2023
  • In: ERJ Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 9:3
  • Journal article (peer-reviewed)abstract
    • Background Tuberculosis (TB) infection induces profound local and systemic, immunological and inflammatory changes that could influence the development of other respiratory diseases; however, the association between TB and asthma is only partly understood. Our objective was to study the association of TB with asthma and respiratory symptoms in a Nordic-Baltic population-based study. Methods We included data from the Respiratory Health in Northern Europe (RHINE) study, in which information on general characteristics, TB infection, asthma and asthma-like symptoms were collected using standardised postal questionnaires. Asthma was defined based on asthma medication usage and/or asthma attacks 12 months prior to the study, and/or by a report of.three out of five respiratory symptoms in the last 12 months. Allergic/nonallergic asthma were defined as asthma with/without nasal allergy. The associations of TB with asthma outcomes were analysed using logistic regressions with adjustments for age, sex, smoking, body mass index and parental education. Results We included 8379 study participants aged 50-75 years, 61 of whom reported having had TB. In adjusted analyses, participants with a history of TB had higher odds of asthma (OR 1.99, 95% CI 1.133.47). The associations were consistent for nonallergic asthma (OR 2.17, 95% CI 1.16-4.07), but not for allergic asthma (OR 1.20, 95% CI 0.53-2.71). Conclusion We found that in a large Northern European population-based cohort, persons with a history of TB infection more frequently had asthma and asthma symptoms. We speculate that this may reflect longterm effects of TB, including direct damage to the airways and lungs, as well as inflammatory responses.
  •  
32.
  • Heldin, Johanna, et al. (author)
  • Clinical remission of asthma and allergic rhinitis : in a longitudinal population study
  • 2022
  • In: Journal of Asthma and Allergy. - : Dove press. - 1178-6965. ; 15, s. 1569-1578
  • Journal article (peer-reviewed)abstract
    • Background: Although asthma and allergic rhinitis are chronic diseases, some patients experience periods of remission. Information on prognostic factors associated with the remission of asthma and allergic rhinitis is valuable in resource prioritization. This study investigated factors associated with the clinical remission of asthma and allergic rhinitis.Methods: In the Respiratory Health In Northern Europe (RHINE) study, data was collected with questionnaires in stage one (RHINE I, 1989–1992) and two follow-ups (RHINE II, 1999–2001 and RHINE III, 2010–2012) from Sweden, Norway, Denmark, Iceland and Estonia. Clinical remission was defined as having reported asthma or allergic rhinitis in RHINE I or RHINE II but not in RHINE III.Results: Of 13,052 participants, 975 (7.5%) reported asthma in RHINE I or RHINE II, and 3379 (25.9%) allergic rhinitis. Clinical remission of asthma and allergic rhinitis was found in 46.4% and 31.8%, respectively. Living in Estonia (OR (95% CI) 2.44 (1.22– 4.85)) and living in an apartment (1.45 (1.06–1.98)) were related to remission of asthma, while subjects reporting allergic rhinitis (0.68 (0.51–0.90)), asthma onset ≤ 12 years of age (0.49 (0.35–0.68)), receiving treatment with antibiotics for respiratory illness (0.64 (0.47– 0.87)) were less likely to have asthma remission. Factors related to a higher likelihood of remission of allergic rhinitis were no asthma at baseline, age ≥ 58 years in RHINE III, allergic rhinitis onset after 12 years of age, living in rural areas as a child, having only a primary school education and not being pregnant.Conclusion: Clinical remission was found in almost one-half of those with asthma and one-third of persons with allergic rhinitis. Coexisting allergic symptoms were associated with less clinical asthma remission. Age, asthma symptoms and environmental factors in childhood, such as living in a rural area, were found to influence the clinical remission of allergic rhinitis.
  •  
33.
  • Heldin, J., et al. (author)
  • Clinical Remission of Asthma and Allergic Rhinitis- in a Longitudinal Population Study
  • 2022
  • In: Journal of Asthma and Allergy. - 1178-6965. ; 15, s. 1569-1578
  • Journal article (peer-reviewed)abstract
    • Background: Although asthma and allergic rhinitis are chronic diseases, some patients experience periods of remission. Information on prognostic factors associated with the remission of asthma and allergic rhinitis is valuable in resource prioritization. This study investigated factors associated with the clinical remission of asthma and allergic rhinitis.Methods: In the Respiratory Health In Northern Europe (RHINE) study, data was collected with questionnaires in stage one (RHINE I, 1989-1992) and two follow-ups (RHINE II, 1999-2001 and RHINE III, 2010-2012) from Sweden, Norway, Denmark, Iceland and Estonia. Clinical remission was defined as having reported asthma or allergic rhinitis in RHINE I or RHINE II but not in RHINE III.Results: Of 13,052 participants, 975 (7.5%) reported asthma in RHINE I or RHINE II, and 3379 (25.9%) allergic rhinitis. Clinical remission of asthma and allergic rhinitis was found in 46.4% and 31.8%, respectively. Living in Estonia (OR (95% CI) 2.44 (1.22- 4.85)) and living in an apartment (1.45 (1.06-1.98)) were related to remission of asthma, while subjects reporting allergic rhinitis (0.68 (0.51-0.90)), asthma onset <= 12 years of age (0.49 (0.35-0.68)), receiving treatment with antibiotics for respiratory illness (0.64 (0.47- 0.87)) were less likely to have asthma remission. Factors related to a higher likelihood of remission of allergic rhinitis were no asthma at baseline, age >= 58 years in RHINE III, allergic rhinitis onset after 12 years of age, living in rural areas as a child, having only a primary school education and not being pregnant.Conclusion: Clinical remission was found in almost one-half of those with asthma and one-third of persons with allergic rhinitis. Coexisting allergic symptoms were associated with less clinical asthma remission. Age, asthma symptoms and environmental factors in childhood, such as living in a rural area, were found to influence the clinical remission of allergic rhinitis.
  •  
34.
  •  
35.
  • Holm, Hannes, et al. (author)
  • A Bayesian network model for likelihood estimations of acquirement of critical software vulnerabilities and exploits
  • 2015
  • In: Information and Software Technology. - : Elsevier BV. - 0950-5849 .- 1873-6025. ; 58, s. 304-318
  • Journal article (peer-reviewed)abstract
    • Context: Software vulnerabilities in general, and software vulnerabilities with publicly available exploits in particular, are important to manage for both developers and users. This is however a difficult matter to address as time is limited and vulnerabilities are frequent. Objective: This paper presents a Bayesian network based model that can be used by enterprise decision makers to estimate the likelihood that a professional penetration tester is able to obtain knowledge of critical vulnerabilities and exploits for these vulnerabilities for software under different circumstances. Method: Data on the activities in the model are gathered from previous empirical studies, vulnerability databases and a survey with 58 individuals who all have been credited for the discovery of critical software vulnerabilities. Results: The proposed model describes 13 states related by 17 activities, and a total of 33 different datasets. Conclusion: Estimates by the model can be used to support decisions regarding what software to acquire, or what measures to invest in during software development projects.
  •  
36.
  • Holm, Hannes (author)
  • A Framework and Calculation Engine for Modeling and Predicting the Cyber Security of Enterprise Architectures
  • 2014
  • Doctoral thesis (other academic/artistic)abstract
    • Information Technology (IT) is a cornerstone of our modern society and essential for governments' management of public services, economic growth and national security. Consequently, it is of importance that IT systems are kept in a dependable and secure state. Unfortunately, as modern IT systems typically are composed of numerous interconnected components, including personnel and processes that use or support it (often referred to as an enterprise architecture), this is not a simple endeavor. To make matters worse, there are malicious actors who seek to exploit vulnerabilities in the enterprise architecture to conduct unauthorized activity within it. Various models have been proposed by academia and industry to identify and mitigate vulnerabilities in enterprise architectures, however, so far none has provided a sufficiently comprehensive scope.The contribution of this thesis is a modeling framework and calculation engine that can be used as support by enterprise decision makers in regard to cyber security matters, e.g., chief information security officers. In summary, the contribution can be used to model and analyze the vulnerability of enterprise architectures, and provide mitigation suggestions based on the resulting estimates. The contribution has been tested in real-world cases and has been validated on both a component level and system level; the results of these studies show that it is adequate in terms of supporting enterprise decision making.This thesis is a composite thesis of eight papers. Paper 1 describes a method and dataset that can be used to validate the contribution described in this thesis and models similar to it. Paper 2 presents what statistical distributions that are best fit for modeling the time required to compromise computer systems. Paper 3 describes estimates on the effort required to discover novel web application vulnerabilities. Paper 4 describes estimates on the possibility of circumventing web application firewalls. Paper 5 describes a study of the time required by an attacker to obtain critical vulnerabilities and exploits for compiled software. Paper 6 presents the effectiveness of seven commonly used automated network vulnerability scanners. Paper 7 describes the ability of the signature-based intrusion detection system Snort at detecting attacks that are more novel, or older than its rule set. Finally, paper 8 describes a tool that can be used to estimate the vulnerability of enterprise architectures; this tool is founded upon the results presented in papers 1-7.
  •  
37.
  • Holm, Hannes, et al. (author)
  • A Manual for the Cyber Security Modeling Language
  • 2013
  • Reports (other academic/artistic)abstract
    • The Cyber Security Modeling Language (CySeMoL) is an attack graph toolthat can be used to estimate the cyber security of enterprise architectures. Cy-SeMoL includes theory on how attacks and defenses relate quantitatively; thus,users must only model their assets and how these are connected in order to enablecalculations. This report functions as a manual to facilitate practical usage andunderstanding of CySeMoL.
  •  
38.
  • Holm, Hannes, et al. (author)
  • A metamodel for web application injection attacks and countermeasures
  • 2012
  • In: Trends in Enterprise Architecture Research and Practice-Driven Research on Enterprise Transformation. - Berlin, Heidelberg : Springer. - 9783642341625 ; , s. 198-217
  • Conference paper (peer-reviewed)abstract
    • Web application injection attacks such as cross site scripting and SQL injection are common and problematic for enterprises. In order to defend against them, practitioners with large heterogeneous system architectures and limited resources struggle to understand the effectiveness of different countermeasures under various conditions. This paper presents an enterprise architecture metamodel that can be used by enterprise decision makers when deciding between different countermeasures for web application injection attacks. The scope of the model is to provide low-effort guidance on an abstraction level of use for an enterprise decision maker. This metamodel is based on a literature review and revised according to the judgment by six domain experts identified through peer-review.
  •  
39.
  • Holm, Hannes, et al. (author)
  • Automatic data collection for enterprise architecture models
  • 2014
  • In: Software and Systems Modeling. - : Springer Science and Business Media LLC. - 1619-1366 .- 1619-1374. ; 13:2, s. 825-841
  • Journal article (peer-reviewed)abstract
    • Enterprise Architecture (EA) is an approach used to provide decision support based on organization-wide models. The creation of such models is, however, cumbersome as multiple aspects of an organization need to be considered, making manual efforts time-consuming, and error prone. Thus, the EA approach would be significantly more promising if the data used when creating the models could be collected automatically-a topic not yet properly addressed by either academia or industry. This paper proposes network scanning for automatic data collection and uses an existing software tool for generating EA models (ArchiMate is employed as an example) based on the IT infrastructure of enterprises. While some manual effort is required to make the models fully useful to many practical scenarios (e.g., to detail the actual services provided by IT components), empirical results show that the methodology is accurate and (in its default state) require little effort to carry out.
  •  
40.
  • Holm, Hannes, et al. (author)
  • CySeMoL : A tool for cyber security analysis of enterprises
  • 2013
  • In: CIRED. - : Institution of Engineering and Technology.
  • Conference paper (peer-reviewed)abstract
    • The Cyber Security ModellingLanguage (CySeMoL) is a tool for quantitative cyber security analyses of enterprise architectures. This paper describes the CySeMoL and illustrates its use through an example scenario involving cyber attacks against protection and control assets located inan electrical substation.
  •  
41.
  • Holm, Hannes, et al. (author)
  • Effort estimates on web application vulnerability discovery
  • 2013
  • Conference paper (peer-reviewed)abstract
    • Web application vulnerabilities are widely considered a serious concern. However, there are as of yet scarce data comparing the effectiveness of different security countermeasures or detailing the magnitude of the security issues associated with web applications. This paper studies the effort that is required by a professional penetration tester to find an input validation vulnerability in an enterprise web application that has been developed in the presence or absence of four security measures: (i) developer web application security training, (ii) type-safe API’s, (iii) black box testing tools, or (iv) static code analyzers. The judgments of 21 experts are collected and combined using Cooke’s classical method. The results show that 53 hours is enough to find a vulnerability with a certainty of 95% even though all measures have been employed during development. If no measure is employed 7 hours is enough to find a vulnerability with 95% certainty.
  •  
42.
  • Holm, Hannes, et al. (author)
  • Empirical Analysis of System-Level Vulnerability Metrics through Actual Attacks
  • 2012
  • In: IEEE Transactions on Dependable and Secure Computing. - 1545-5971 .- 1941-0018. ; 9:6, s. 825-837
  • Journal article (peer-reviewed)abstract
    • The Common Vulnerability Scoring System (CVSS) is a widely used and well-established standard for classifying the severity of security vulnerabilities. For instance, all vulnerabilities in the US National Vulnerability Database (NVD) are scored according to this method. As computer systems typically have multiple vulnerabilities, it is often desirable to aggregate the score of individual vulnerabilities to a system level. Several such metrics have been proposed, but their quality has not been studied. This paper presents a statistical analysis of how 18 security estimation metrics based on CVSS data correlate with the time-to-compromise of 34 successful attacks. The empirical data originates from an international cyber defense exercise involving over 100 participants and were collected by studying network traffic logs, attacker logs, observer logs, and network vulnerabilities. The results suggest that security modeling with CVSS data alone does not accurately portray the time-to-compromise of a system. However, results also show that metrics employing more CVSS data are more correlated with time-to-compromise. As a consequence, models that only use the weakest link (most severe vulnerability) to compose a metric are less promising than those that consider all vulnerabilities.
  •  
43.
  • Holm, Hannes, et al. (author)
  • Estimates on the effectiveness of web application firewalls against targeted attacks
  • 2013
  • In: Information Management & Computer Security. - 0968-5227 .- 1758-5805. ; 21:4, s. 250-265
  • Journal article (peer-reviewed)abstract
    • Purpose – The purpose of this paper is to estimate the effectiveness of web application firewalls (WAFs) at preventing injection attacks by professional penetration testers given presence or absence of four conditions: whether there is an experienced operator monitoring the WAF; whether an automated black box tool has been used when tuning the WAF; whether the individual tuning the WAF is an experienced professional; and whether significant effort has been spent tuning the WAF.Design/methodology/approach – Estimates on the effectiveness of WAFs are made for 16 operational scenarios utilizing judgments by 49 domain experts participating in a web survey. The judgments of these experts are pooled using Cooke's classical method.Findings – The results show that the median prevention rate of a WAF is 80 percent if all measures have been employed. If no measure is employed then its median prevention rate is 25 percent. Also, there are no strong dependencies between any of the studied measures.Research limitations/implications – The results are only valid for the attacker profile of a professional penetration tester who prepares one week for attacking a WA protected by a WAF.Practical implications – The competence of the individual(s) tuning a WAF, employment of an automated black box tool for tuning and the manual effort spent on tuning are of great importance for the effectiveness of a WAF. The presence of an operator monitoring it has minor positive influence on its effectiveness.Originality/value – WA vulnerabilities are widely considered a serious concern. To manage them in deployed software, many enterprises employ WAFs. However, the effectiveness of this type of countermeasure under different operational scenarios is largely unknown.
  •  
44.
  • Holm, Hannes, et al. (author)
  • Expert assessment on the probability of successful remote code execution attacks
  • 2011
  • In: Proceedings of 8th International Workshop on Security in Information Systems - WOSIS 2011. - 9789898425614 ; , s. 49-58
  • Conference paper (peer-reviewed)abstract
    • This paper describes a study on how cyber security experts assess the importance of three variables related to the probability of successful remote code execution attacks – presence of: (i) non-executable memory, (ii) access and (iii) exploits for High or Medium vulnerabilities as defined by the Common Vulnerability Scoring System. The rest of the relevant variables were fixed by the environment of a cyber defense exercise where the respondents participated. The questionnaire was fully completed by fifteen experts. These experts perceived access as the most important variable and availability of exploits for High vulnerabilities as more important than Medium vulnerabilities. Non-executable memory was not seen as significant, however, presumably due to lack of address space layout randomization and canaries in the network architecture of the cyber defense exercise scenario.
  •  
45.
  • Holm, Hannes, et al. (author)
  • Indicators of expert judgement and their significance : An empirical investigation in the area of cyber security
  • 2014
  • In: Expert systems (Print). - : Wiley. - 0266-4720 .- 1468-0394. ; 3:4, s. 299-318
  • Journal article (peer-reviewed)abstract
    • In situations when data collection through observations is difficult to perform, the use of expert judgement can be justified. A challenge with this approach is, however, to value the credibility of different experts. A natural and state-of-the art approach is to weight the experts' judgements according to their calibration, that is, on the basis of how well their estimates of a studied event agree with actual observations of that event. However, when data collection through observations is difficult to perform, it is often also difficult to estimate the calibration of experts. As a consequence, variables thought to indicate calibration are generally used as a substitute of it in practice. This study evaluates the value of three such indicative variables: consensus, experience and self-proclamation. The significances of these variables are analysed in four surveys covering different domains in cyber security, involving a total of 271 subjects. Results show that consensus is a reasonable indicator of calibration. The mean Pearson correlation between these two variables across the four studies was 0.407. No significant correlations were found between calibration and experience or calibration and self-proclamation. However, as a side result, it was discovered that a subject that perceives itself as more knowledgeable than others likely also is more experienced.
  •  
46.
  • Holm, Hannes, et al. (author)
  • P2CySeMoL : Predictive, Probabilistic Cyber Security Modeling Language
  • 2015
  • In: IEEE Transactions on Dependable and Secure Computing. - : IEEE Press. - 1545-5971 .- 1941-0018. ; 12:6, s. 626-639
  • Journal article (peer-reviewed)abstract
    • This paper presents the Predictive, Probabilistic Cyber Security Modeling Language ((PCySeMoL)-Cy-2), an attack graph tool that can be used to estimate the cyber security of enterprise architectures. (PCySeMoL)-Cy-2 includes theory on how attacks and defenses relate quantitatively; thus, users must only model their assets and how these are connected in order to enable calculations. The performance of (PCySeMoL)-Cy-2 enables quick calculations of large object models. It has been validated on both a component level and a system level using literature, domain experts, surveys, observations, experiments and case studies.
  •  
47.
  • Holm, Hannes, et al. (author)
  • Success Rate of Remote Code Execution Attacks : Expert Assessments and Observations
  • 2012
  • In: Journal of universal computer science (Online). - : J.UCS consortium. - 0948-695X .- 0948-6968. ; 18:6, s. 732-749
  • Journal article (peer-reviewed)abstract
    • This paper describes a study on how cyber security experts assess the importance of three variables related to the probability of successful remote code execution attacks: (i) non-executable memory, (ii) access and (iii) exploits for High or Medium vulnerabilities as defined by the Common Vulnerability Scoring System. The rest of the relevant variables were fixed by the environment of a cyber defense exercise where the respondents participated. The questionnaire was fully completed by fifteen experts. These experts perceived access as the most important variable and availability of exploits for High vulnerabilities as more important than Medium vulnerabilities. Non-executable memory was not seen as significant. Estimates by the experts are compared to observations of actual attacks carried out during the cyber defense exercise. These comparisons show that experts' in general provide fairly inaccurate advice on an abstraction level such as in the present study. However, results also show a prediction model constructed through expert judgment likely is of better quality if the experts' estimates are weighted according to their expertise.
  •  
48.
  •  
49.
  • Holm, Mathias, 1969, et al. (author)
  • Acute effects after occupational endotoxin exposure at a spa.
  • 2009
  • In: Scandinavian journal of work, environment & health. - 0355-3140. ; 35:2, s. 153-5
  • Journal article (other academic/artistic)abstract
    • OBJECTIVES: Two spa workers reported such symptoms as fever, shivering, palpitation, arthralgia, and diarrhea after performing seaweed massages on clients at a spa center. This study was carried out to determine whether the symptoms were related to exposure to endotoxin. METHODS: Personal and stationary air sampling for the measurement of airborne endotoxin was carried out at the spa during the preparation of a bath and the following seaweed massage. In addition, the impact of storage time on the concentration of endotoxin in the seaweed was investigated. RESULTS: The measurements confirmed exposure to aerosolized endotoxin at the spa (11 ng/m (2)and 22 ng/m (3)). The endotoxin concentration in the stored seaweed increased as the storage time increased, from 360 ng/g seaweed for fresh seaweed to 33100 ng/g seaweed for seaweed stored for >20 weeks. CONCLUSIONS: Organic dust toxic syndrome was diagnosed for two workers who performed seaweed massages at a spa center at which aerosolized endotoxin was measured. In order to minimize entotoxin exposure during massages, it is important to use fresh seaweed or seaweed kept well cooled for no more than 2-3 weeks.
  •  
50.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-50 of 162
Type of publication
journal article (144)
conference paper (11)
reports (4)
other publication (1)
doctoral thesis (1)
research review (1)
show more...
show less...
Type of content
peer-reviewed (141)
other academic/artistic (21)
Author/Editor
Janson, Christer (76)
Holm, Mathias, 1969 (74)
Holm, Mathias (37)
Johannessen, A. (35)
Malinovschi, Andrei, ... (35)
Schlunssen, V. (33)
show more...
Forsberg, Bertil (32)
Schlunssen, Vivi (32)
Holm, Hannes (31)
Franklin, Karl A. (31)
Svanes, C. (30)
Johannessen, Ane (30)
Ekstedt, Mathias (30)
Gislason, Thorarinn (29)
Svanes, Cecilie (28)
Lindberg, Eva (27)
Gislason, T. (26)
Jogi, Rain (25)
Benediktsdottir, Bry ... (24)
Heinrich, Joachim (21)
Sigsgaard, Torben (20)
Sommestad, Teodor (18)
Benediktsdottir, B. (17)
Real, F. G. (17)
Jögi, Rain (17)
Bråbäck, Lennart (16)
Torén, Kjell, 1952 (15)
Bertelsen, R. J. (15)
Norbäck, Dan (14)
Modig, Lars (14)
Sigsgaard, T. (14)
Heinrich, J. (13)
Leynaert, Benedicte (13)
Jogi, R. (12)
Marcon, Alessandro (11)
Jogi, N. O. (11)
Dharmage, S. C. (10)
Jarvis, D. (10)
Accordini, Simone (10)
Probst-Hensch, Nicol ... (10)
Leynaert, B. (9)
Sanchez-Ramos, J. L. (9)
Orru, Hans (9)
Markevych, Iana (9)
Nowak, Dennis (9)
Accordini, S. (8)
Garcia-Aymerich, Jud ... (8)
Pin, Isabelle (8)
Jarvis, Debbie (8)
Wang, Juan (8)
show less...
University
Umeå University (92)
Uppsala University (88)
University of Gothenburg (80)
Royal Institute of Technology (32)
Lund University (11)
Karolinska Institutet (9)
show more...
Swedish University of Agricultural Sciences (3)
Stockholm University (2)
Linköping University (2)
University of Skövde (2)
Kristianstad University College (1)
Chalmers University of Technology (1)
Högskolan Dalarna (1)
show less...
Language
English (161)
Swedish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (118)
Natural sciences (25)
Engineering and Technology (17)
Agricultural Sciences (2)
Social Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view