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  • Sun, HM, et al. (author)
  • Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
  • 2004
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5688, s. 1283-1286
  • Journal article (peer-reviewed)abstract
    • Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Ginsburg, D. (1)
Wang, XX (1)
Sjöbring, Ulf (1)
Ringdahl, Ulrika (1)
Engleberg, NC (1)
Fay, WP (1)
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Sun, HM (1)
Homeister, JW (1)
Yang, AY (1)
Rozek, LS (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2004 (1)

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