| 1. |
- Locke, Adam E, et al.
(author)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Journal article (peer-reviewed)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 2. |
- Berndt, Sonja I., et al.
(author)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Journal article (peer-reviewed)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 3. |
- Joshi, Peter K, et al.
(author)
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Directional dominance on stature and cognition in diverse human populations
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 523:7561, s. 459-462
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Journal article (peer-reviewed)abstract
- Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
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| 4. |
- Abolfathi, Bela, et al.
(author)
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The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
- 2018
-
In: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
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Journal article (peer-reviewed)abstract
- The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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| 5. |
- Beecham, Ashley H, et al.
(author)
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- 2013
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:11, s. 1353-60
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Journal article (peer-reviewed)abstract
- Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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| 6. |
- Sawcer, Stephen, et al.
(author)
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- 2011
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 476:7359, s. 214-219
-
Journal article (peer-reviewed)abstract
- Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
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| 7. |
- Craddock, Nick, et al.
(author)
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
- 2010
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
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Journal article (peer-reviewed)abstract
- Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
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| 8. |
- Fletcher, Tim D., et al.
(author)
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SUDS, LID, BMPs, WSUD and more : The evolution and application of terminology surrounding urban drainage
- 2015
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In: Urban Water Journal. - 1573-062X. ; 12:7, s. 525-542
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Journal article (peer-reviewed)abstract
- The management of urban stormwater has become increasingly complex over recent decades. Consequently, terminology describing the principles and practices of urban drainage has become increasingly diverse, increasing the potential for confusion and miscommunication. This paper documents the history, scope, application and underlying principles of terms used in urban drainage and provides recommendations for clear communication of these principles. Terminology evolves locally and thus has an important role in establishing awareness and credibility of new approaches and contains nuanced understandings of the principles that are applied locally to address specific problems. Despite the understandable desire to have a 'uniform set of terminology', such a concept is flawed, ignoring the fact that terms reflect locally shared understanding. The local development of terminology thus has an important role in advancing the profession, but authors should facilitate communication between disciplines and between regions of the world, by being explicit and accurate in their application. © 2014 © The work of Tim D. Fletcher is Crown copyright in the Commonwealth of Australia 2014, University of Melbourne. The work of Danielle Dagenais is Copyright of the Crown in Canada 2014, University of Montreal. The work of William Shuster was authored as part of his official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 USC. 105, no copyright protection is available for such works under US Law. William F. Hunt, Richard Ashley, David Butler, Scott Arthur, Sam Trowsdale, Sylvie Barraud, Annette Semadeni-Davies, Jean-Luc Bertrand-Krajewski, Peter Steen Mikkelsen, Gilles Rivard, Mathias Uhl and Maria Viklander hereby waive their right to assert copyright, but not their right to be named as co-authors in the article.
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| 9. |
- Sung, Yun Ju, et al.
(author)
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A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
- 2019
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 28:15, s. 2615-2633
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Journal article (peer-reviewed)abstract
- Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
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| 10. |
- Tinetti, G., et al.
(author)
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A chemical survey of exoplanets with ARIEL
- 2018
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In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 46:1, s. 135-209
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Journal article (peer-reviewed)abstract
- Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.
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| 11. |
- Aguado, D. S., et al.
(author)
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The Fifteenth Data Release of the Sloan Digital Sky Surveys : First Release of MaNGA-derived Quantities, Data Visualization Tools, and Stellar Library
- 2019
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In: Astrophysical Journal Supplement Series. - : Institute of Physics Publishing (IOPP). - 0067-0049 .- 1538-4365. ; 240:2
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Journal article (peer-reviewed)abstract
- Twenty years have passed since first light for the Sloan Digital Sky Survey (SDSS). Here, we release data taken by the fourth phase of SDSS (SDSS-IV) across its first three years of operation (2014 July-2017 July). This is the third data release for SDSS-IV, and the 15th from SDSS (Data Release Fifteen; DR15). New data come from MaNGA-we release 4824 data cubes, as well as the first stellar spectra in the MaNGA Stellar Library (MaStar), the first set of survey-supported analysis products (e.g., stellar and gas kinematics, emission-line and other maps) from the MaNGA Data Analysis Pipeline, and a new data visualization and access tool we call "Marvin." The next data release, DR16, will include new data from both APOGEE-2 and eBOSS; those surveys release no new data here, but we document updates and corrections to their data processing pipelines. The release is cumulative; it also includes the most recent reductions and calibrations of all data taken by SDSS since first light. In this paper, we describe the location and format of the data and tools and cite technical references describing how it was obtained and processed. The SDSS website (www.sdss.org) has also been updated, providing links to data downloads, tutorials, and examples of data use. Although SDSS-IV will continue to collect astronomical data until 2020, and will be followed by SDSS-V (2020-2025), we end this paper by describing plans to ensure the sustainability of the SDSS data archive for many years beyond the collection of data.
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| 12. |
- Blecken, Godecke-Tobias, et al.
(author)
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Stormwater control measure (SCM) maintenance considerations to ensure designed functionality
- 2017
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In: Urban Water Journal. - : Taylor & Francis. - 1573-062X. ; 14:3, s. 278-290
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Journal article (peer-reviewed)abstract
- Great investment is made in the design and installation of stormwater control measures (SCMs). Substantial research investment, too, is made to optimise the performance of SCMs. However, once installed, SCMs often suffer from lack of maintenance or even outright neglect. Key maintenance needs for wet ponds, constructed stormwater wetlands, bioretention, infiltration practices, permeable pavement, swales, and rainwater harvesting systems are reviewed with many tasks, such as the cleaning of pre-treatment areas and the preservation of infiltration surfaces, being common maintenance themes among SCMs. Consequences of lacking maintenance are illustrated (mainly insufficient function or failure). Probable reasons for neglect include insufficient communication, unclear responsibilities, lack of knowledge, financial barriers, and decentralised measures. In future designs and research, maintenance (and lack thereof) should be considered. Assessing the performance of SCMs conservatively and including safety factors may prevent consequences of under-maintenance; and requiring regular inspection may help to enforce sufficient maintenance.
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| 13. |
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| 14. |
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| 15. |
- Al-Rubaei, Ahmed, et al.
(author)
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Survey of the operational status of 25 Swedish municipal stormwater management ponds
- 2017
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In: Journal of environmental engineering. - : American Society of Civil Engineers (ASCE). - 0733-9372 .- 1943-7870. ; 143:6
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Journal article (peer-reviewed)abstract
- During the past 50 years, wet stormwater ponds have been constructed to reduce negative environmental impacts of urban stormwater discharges on receiving aquatic environments. However, in many jurisdictions there is little information on the current operational status of such ponds and their functioning. This paucity of information prompted a field survey of 25 Swedish municipal stormwater ponds, aged between 3 and 26 years. The pond survey focused on estimating the pond hydraulic loading and efficiency, the state of littoral vegetation, characteristics of bottom sediment in the inlet and outlet zones (sizes and the chemistry), and the overall operational pond status, including the access for maintenance. The hydraulic efficiencies of ponds were estimated for pond footprint shapes and relative locations of the inlets and outlets using literature data. The estimated hydraulic efficiencies correlated well with the pond length-to-width ratios and the ratio of the pond surface area to the impervious area of the runoff contributing catchment (i.e., the hydraulic loading). Littoral vegetation was inspected visually and found to be overgrown at some facilities, which impeded the maintenance access. Benthic sediments in ponds contained silt and clay (<63 μm" role="presentation" style="box-sizing: border-box; display: inline; line-height: normal; word-spacing: normal; word-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;"><63 μm<63 μm), sand and gravel fractions, and when compared with the literature data, such sediments appeared relatively coarse. Chemical characteristics of sediments reflected anthropogenic (traffic) activities, but without excessive contamination warranting special disposal requirements. Of the 25 ponds surveyed, four were fenced off and inaccessible to machinery. In fact, the design of these four ponds was such that it made inspection and maintenance very difficult, which may pose potential risks to ponds operation. Fifty-four percent of the investigated ponds were in need of minor maintenance, primarily because of sediment and litter accumulation in their inflow and outflow sections. The fact that the inspection survey revealed relatively few minor issues that could be corrected easily demonstrates the importance of relatively simple regular inspections serving to detect minor problems at an early stage before they would seriously impact pond functioning. The above survey methodology should be helpful for developing similar low-cost surveys in other jurisdictions.
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| 16. |
- Beryani, Ali, et al.
(author)
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Survey of the Operational Status of Twenty-six Urban Stormwater Biofilter Facilities in Sweden
- 2021
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In: Journal of Environmental Management. - : Elsevier. - 0301-4797 .- 1095-8630. ; 297
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Journal article (peer-reviewed)abstract
- This study evaluates the operational status of twenty-six biofilter facilities across nine cities in Sweden, with respect to their functional design criteria, engineered design features (filter media composition, hydraulic conductivity, and drawdown time), and includes a visual inspection of the biofilter components (pre-treatment, in/outlet structures, filter media, and vegetation). These indicators were used to examine the performance level of each biofilter in achieving their design objectives set by the operators. Furthermore, it was investigated whether the biofilter facilities had been properly maintained to meet the objectives. Results indicate that the soil media used was consistent with respect to percentage sand, fines, and organic matter and comparable to design recommendations used by municipalities in other countries. The field-tested hydraulic conductivity for the biofilters ranged from 30 to 962 mm/h. This range of values, along with noticeable sediment accumulation within the biofilter indicate that not all the sites were operating optimally. Pre-treatment stages in poor condition with high volumes of sediment and litter accumulation were the primary causes for, and indicators of, low hydraulic conductivity rates. The ponding volume calculations revealed that at least 40 % of facilities did not have enough capacity to retain every-day and/or design rainfall due to design and/or construction flaws. These analyses raise concerns that, for a considerable number of the biofilters surveyed, water retention and flood protection identified by operators as prioritised objectives are not being met. This raises significant concerns about the functionality of biofilter in practice. Finally, some suggestions are given for tackling the design and maintenance problems discovered.
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| 17. |
- Blecken, Godecke, et al.
(author)
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Översiktlig utvärderingav funktionaliteten av 26 dagvattenbiofilter
- 2021
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Other publication (other academic/artistic)abstract
- Implementering av dagvattenbiofilter i Sverige har ökat de senaste åren. Dock har det länge saknats dimensioneringsriktlinjer och filtrens utformning, dimensionering och konstruktion visar stora skillnader. Denna studie har på en översiktlig nivå undersökt funktionen och tillstånd av 26 svenska dagvattenbiofilter som har byggts mellan 2012 och 2019. Utifrån observationerna har vi sammanställt "typiska fel" och rekommenderar åtgärder för att förbättra funktionen. Syften med anläggningarna har jämförts med observationerna. Resultaten visar att många anläggningar har potential att uppfylla de uppsatta målen.
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| 18. |
- Ekka, Sujit A., et al.
(author)
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Next generation swale design for stormwater runoff treatment : A comprehensive approach
- 2021
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In: Journal of Environmental Management. - : Elsevier. - 0301-4797 .- 1095-8630. ; 279
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Research review (peer-reviewed)abstract
- Swales are the oldest and most common stormwater control measure for conveying and treating roadway runoff worldwide. Swales are also gaining popularity as part of stormwater treatment trains and as crucial elements in green infrastructure to build more resilient cities. To achieve higher pollutant reductions, swale alternatives with engineered media (bioswales) and wetland conditions (wet swales) are being tested. However, the available swale design guidance is primarily focused on hydraulic conveyance, overlooking their function as an important water quality treatment tool. The objective of this article is to provide science-based swale design guidance for treating targeted pollutants in stormwater runoff. This guidance is underpinned by a literature review.The results of this review suggest that well-maintained grass swales with check dams or infiltration swales are the best options for runoff volume reduction and removal of sediment and heavy metals. For nitrogen removal, wet swales are the most effective swale alternative. Bioswales are best for phosphorus and bacteria removal; both wet swales and bioswales can also treat heavy metals. Selection of a swale type depends on the site constraints, local climate, and available funding for design, construction, and operation. Appropriate siting, pre-design site investigations, and consideration of future maintenance during design are critical to successful long-term swale performance. Swale design recommendations based on a synthesis of the available research are provided, but actual design standards should be developed using local empirical data. Future research is necessary to identify optimal design parameters for all swale types, especially for wet swales.
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| 19. |
- Jendle, Johan, 1963-, et al.
(author)
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Achieving Good Glycemic Control Early After Onset of Diabetes : A Cost-Effectiveness Analysis in Patients with Type 1 Diabetes in Sweden
- 2018
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In: Diabetes Therapy. - : Springer. - 1869-6953 .- 1869-6961. ; 9:1, s. 87-99
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Journal article (peer-reviewed)abstract
- INTRODUCTION: Sweden has amongst the highest incidence rates of type 1 diabetes (T1D) in Europe. The high incidence and chronic nature of T1D result in high prevalence and economic burden. Improving glycemic control reduces the incidence of microvascular complications, which in turn reduces medical costs. The present study aimed to quantify the reductions in cost and improvements in quality-adjusted life expectancy with varying reductions in HbA1c in the T1D population.METHODS: The IQVIA CORE Diabetes Model was used to simulate a typical Swedish population of patients with T1D experiencing HbA1c reductions from 0.1% to 0.8% (in 0.1% increments) from 7.9% at baseline. Analyses were conducted in simulated cohorts based on data from the Swedish National Diabetes Register (NDR) and in subgroups by sex, smoking status, and body mass index (BMI), with different sets of quality-of-life utilities included. Generalized least squares (GLS) models were used to test for significant differences between subgroups. Analyses were also performed to investigate the effect of the duration of HbA1c control. Analyses were run over 50 years and outcomes discounted at 3% per annum.RESULTS: In the reference case analysis, reducing HbA1c lowered the incidence of microvascular and macrovascular complications and improved quality-adjusted life expectancy. GLS models identified a significantly larger benefit of reducing HbA1c in women over men, but found no significant differences in the magnitude of quality of life improvements with decreasing HbA1c when segregating by smoking status or BMI.CONCLUSIONS: Reducing HbA1c in a population with T1D would reduce the incidence of microvascular complications, improve life expectancy and quality of life. Larger quality-of-life benefits were observed in younger and female adult patients, but no notable differences were observed in the benefits of glycemic control in smokers versus non-smokers or in patients with low or high BMI.
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| 20. |
- Merriman, Laura S., et al.
(author)
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Evaluation of factors affecting soil carbon sequestration services of stormwater wet retention ponds in varying climate zones.
- 2017
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In: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 583, s. 133-141
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Journal article (peer-reviewed)abstract
- The carbon sequestration services of stormwater wet retention ponds were investigated in four different climates: U.S., Northern Sweden, Southern Sweden, and Singapore, representing a range of annual mean temperatures, growing season lengths and rainfall depths: geographic factors that were not statistically compared, but have great effect on carbon (C) accumulation. A chronosequence was used to estimate C accumulations rates; C accumulation and decomposition rates were not directly measured. C accumulated significantly over time in vegetated shallow water areas (0–30 cm) in the USA (78.4 g C m− 2 yr− 1), in vegetated temporary inundation zones in Sweden (75.8 g C m− 2 yr− 1), and in all ponds in Singapore (135 g C m− 2 yr− 1). Vegetative production appeared to exert a stronger influence on relative C accumulation rates than decomposition. Comparing among the four climatic zones, the effects of increasing rainfall and growing season lengths (vegetative production) outweighed the effects of higher temperature on decomposition rates. Littoral vegetation was a significant source to the soil C pool relative to C sources draining from watersheds. Establishment of vegetation in the shallow water zones of retention ponds is vital to providing a C source to the soil. Thus, the width of littoral shelves containing this vegetation along the perimeter may be increased if C sequestration is a design goal. This assessment establishes that stormwater wet retention ponds can sequester C across different climate zones with generally annual rainfall and lengths of growing season being important general factors for C accumulation.
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| 21. |
- Rauch, Wolfgang, et al.
(author)
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Stormwater in urban areas
- 2012
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In: Water Research. - : Elsevier BV. - 0043-1354 .- 1879-2448. ; 46:20, s. 6588-6588
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Journal article (other academic/artistic)abstract
- Collection, storage and treatment of stormwater in urban areas has been one of the classical disciplines of sanitary and environmental engineering in the past. Waste and pollution transported by stormwater poses quantity and quality problems, is affecting public health and threatens the quality of the environment – most important surface water ecosystems. While traditional solutions have been mostly concerned with discharge and storage, quality issues gained increasing attention over the last years. Reason being both the pollution of the receiving water due to urban stormwater management and the potential use of stormwater as an alternative source of freshwater. This special issue of Water Research covers the most important issues related to management of stormwater in 26 articles. The objective is to give the reader an overview of the state of the art by presenting the most recent findings of high quality research within the new hot topics related to stormwater.The first part of this issue presents findings with relation to stormwater quality. The manuscripts deal with highway runoff, toxic substances, pathogens and priority pollutants. Results are given from monitoring campaigns (mostly from US, Europe and Australia) but also in the context of comprehensive literature reviews.The second half of the issue deals more broadly with a wider spectrum of topics. Papers are covering hydraulic aspects, filtration and clogging of stormwater facilities like swales, permeable pavement and biofilters. Another range of papers accounts for design principles of stormwater management, specifically focusing on sustainable solutions but also on the effect to pluvial flooding. Modeling, data treatment and uncertainty analysis with relation to stormwater concludes the special issue.The editors hope that by reading these papers major challenges will be visualized to the readers but also that there are promising solutions available to these challenges. We appreciate the valuable support of our colleagues who have devoted their time to review the manuscripts and thus ensure the quality of this issue. We also express sincere thanks to the staff of Water Research for their valuable editorial support.
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| 22. |
- Winston, Ryan, et al.
(author)
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A Simple Infiltration Test for Determination of Permeable Pavement Maintenance Needs
- 2016
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In: Journal of environmental engineering. - 0733-9372 .- 1943-7870. ; 142:10
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Journal article (peer-reviewed)abstract
- Permeable pavements allow stormwater to pass through the pavement surface, filtering out sediment and debris; over time, regular preventative maintenance will be needed to maintain the pavement surface infiltration rate (IR). IR testing is commonly used to determine maintenance needs and frequencies. ASTM standard methods may be used to measure permeable pavement IR; however, these tests can take hours to complete and require infiltrometers not readily available to maintenance contractors. A simple infiltration test (SIT) has been devised which (1) is conducted using easily acquired materials, (2) has a larger surface area (i.e., more representative of average pavement conditions), and (3) requires, on average, 72% less time to conduct than the ASTM test. ASTM and SIT methods were compared by conducting a total of 873 IR tests at the same locations on 12 permeable pavements in North Carolina, Ohio, and Sweden. Results showed that (1) a segmented linear relationship related SIT and ASTM-measured IRs; (2) the SIT and ASTM tests predicted approximately the same IR up to 250 mm/min 250 mm/min; (3) the larger surface area of the SIT reduced the variability in measurements (average 40% less) compared to the ASTM method. The SIT took one-quarter the time to run, on average, making this newly-devised tool more efficient when assessing IR than ASTM methods, potentially saving maintenance personnel time and money.
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