| 1. |
- Barrett, Scott, et al.
(author)
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Social dimensions of fertility behavior and consumption patterns in the Anthropocene
- 2020
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:12, s. 6300-6307
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Journal article (peer-reviewed)abstract
- We consider two aspects of the human enterprise that profoundly affect the global environment: population and consumption. We show that fertility and consumption behavior harbor a class of externalities that have not been much noted in the literature. Both are driven in part by attitudes and preferences that are not egoistic but socially embedded; that is, each household's decisions are influenced by the decisions made by others. In a famous paper, Garrett Hardin [G. Hardin, Science 162, 1243-1248 (1968)] drew attention to overpopulation and concluded that the solution lay in people abandoning the freedom to breed. That human attitudes and practices are socially embedded suggests that it is possible for people to reduce their fertility rates and consumption demands without experiencing a loss in wellbeing. We focus on fertility in sub-Saharan Africa and consumption in the rich world and argue that bottom-up social mechanisms rather than top-down government interventions are better placed to bring about those ecologically desirable changes.
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| 2. |
- Bergquist, Annika, et al.
(author)
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Impact on follow-up strategies in patients with primary sclerosing cholangitis
- 2023
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In: Liver international (Print). - Chichester, United Kingdom : Wiley-Blackwell Publishing Inc.. - 1478-3223 .- 1478-3231. ; 43:1, s. 127-138
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Journal article (peer-reviewed)abstract
- BACKGROUND & AIMS: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in PSC with the hypothesis that regular imaging improves survival.METHODS: We collected retrospective data from 2,975 PSC patients from 27 centers. Patients were followed from the start of scheduled imaging or in case of clinical follow-up from January 1, 2000, until death or last clinical follow-up alive. The primary endpoint was all-cause mortality.RESULTS: A broad variety of different follow-up strategies were reported. All except one center used regular imaging, ultrasound (US) and/or magnetic resonance imaging (MRI). Two centers used scheduled ERCP in addition to imaging for surveillance purposes. The overall HR (CI95%) for death, adjusted for sex, age and start year of follow-up, were 0.61 (0.47-0.80) for scheduled imaging with and without ERCP; 0.64 (0.48-0.86) for US/MRI and 0.53 (0.37-0.75) for follow-up strategies including scheduled ERCP. The lower risk of death remained for scheduled imaging with and without ERCP after adjustment for cholangiocarcinoma (CCA) or high-grade dysplasia as a time-dependent covariate, HR 0.57 (0.44-0.75). Hepatobiliary malignancy was diagnosed in 175 (5.9%) of the patients at 7.9 years follow-up. Asymptomatic patients (25%) with CCA had better survival if scheduled imaging had been performed.CONCLUSIONS: Follow-up strategies vary considerably across centers. Scheduled imaging was associated with improved survival. Multiple factors may contribute to this result including early tumor detection and increased endoscopic treatment of asymptomatic benign biliary strictures.
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| 3. |
- Borup, Anders Bæk, et al.
(author)
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Unveiling the formation mechanism of PbxPdy intermetallic phases in solvothermal synthesis using in situ X-ray total scattering
- 2023
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In: Nanoscale. - 2040-3364. ; 15:45, s. 18481-18488
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Journal article (peer-reviewed)abstract
- Pd possesses attractive catalytic properties and nano-structuring is an obvious way to enhance catalytic activity. Alloying Pd with Pb has been shown to enhance the catalytic effect of alcohol oxidation. Further optimization of the catalytic effect can be accomplished by controlling the particle size and key to this is understanding the formation mechanism. By monitoring solvothermal syntheses using in situ X-ray total scattering, this study unveils the formation mechanism of PbxPdy intermetallic nanoparticles. The formation occurs through a multi-step mechanism. Initially, Pd nanoparticles are formed, followed by incorporation of Pb into the Pd-structure, thus forming PbxPdy intermetallic nanoparticles. By varying the reaction time and temperature, the incorporation of Pb can be controlled, thereby tailoring the phase outcome. Based on the in situ solvothermal syntheses, ex situ autoclave syntheses were performed, resulting in the synthesis of Pb3Pd5 and Pb9Pd13 with a purity above 93%. The catalytic effect of these intermetallic phases towards the hydrogen evolution reaction (HER) is assessed. It is found that Pd, Pb3Pd5, and Pb9Pd13 have comparable stabilities, however, the overpotential increases with increasing amounts of Pb.
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| 4. |
- Broge, Nils Lau Nyborg, et al.
(author)
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Exploration of anion effects in solvothermal synthesis using in situ X-ray diffraction
- 2024
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In: Physical Chemistry Chemical Physics. - 1463-9076. ; 26:15, s. 12121-12132
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Journal article (peer-reviewed)abstract
- Solvothermal synthesis presents a facile and highly flexible approach to chemical processing and it is widely used for preparation of micro- and nanosized inorganic materials. The large number of synthesis parameters in combination with the richness of inorganic chemistry means that it is difficult to predict or design synthesis outcomes, and it is demanding to uncover the effect of different parameters due to the sealed and complex nature of solvothermal reactors along with the time demands related to reactor cleaning, sample purification, and characterization. This study explores the effect on formation of crystalline products of six common anions in solvothermal treatment of aqueous and ethanolic precursors. Three different cations are included in the study (Mn2+, Co2+, Cu2+) representing chemical affinities towards different regions of the periodic table with respect to the hard soft acid base (HSAB) classification and the Goldschmidt classification. They additionally belong to the commonly used 3d transition metals and display a suitable variety in solvothermal chemistry to highlight anion effects. The results of the solvothermal in situ experiments demonstrate a clear effect of the precursor anions, with respect to whether crystallization occurs or not and the characteristics of the formed phases. Additionally, some of the anions are shown to be redox active and to influence the formation temperature of certain phases which in turn relates to the observed average crystallite sizes.
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| 5. |
- Buch-Rasmussen, Thomas
(creator_code:cre_t)
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Coating system providing low friction
- 1999
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Patent (other academic/artistic)abstract
- The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper. The coatings according to the present invention are especially suited to use for permanently coating internal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations. The coatings providing low friction between the two components, such as a container wall and a rubber stopper, result in high-precision dosing. The described coatings are particularly useful for coating containers for storage and administration of liquid protein solutions, such as insulin formulations.
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| 6. |
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| 7. |
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| 8. |
- Eriksson, Daniel, et al.
(author)
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GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
- 2021
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 12:1
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Journal article (peer-reviewed)abstract
- Autoimmune Addison's disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10-8). In addition to loci implicated in lymphocyte function and development shared with other autoimmune diseases such as HLA, BACH2, PTPN22 and CTLA4, we associate two protein-coding alterations in Autoimmune Regulator (AIRE) with AAD. The strongest, p.R471C (rs74203920, OR = 3.4 (2.7-4.3), P = 9.0 × 10-25) introduces an additional cysteine residue in the zinc-finger motif of the second PHD domain of the AIRE protein. This unbiased elucidation of the genetic contribution to development of AAD points to the importance of central immunological tolerance, and explains 35-41% of heritability (h2).
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| 9. |
- Gaspar Sánchez, José Manuel, et al.
(author)
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Edge computing for cyber-physical systems : A Systematic Mapping Study Emphasizing Trustworthiness
- 2022
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In: ACM Transactions on Cyber-Physical Systems. - : Association for Computing Machinery (ACM). - 2378-962X .- 2378-9638. ; 6:3, s. 1-28
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Journal article (peer-reviewed)abstract
- Edge computing is projected to have profound implications in the coming decades, proposed to provide solutions for applications such as augmented reality, predictive functionalities, and collaborative Cyber-Physical Systems (CPS). For such applications, edge computing addresses the new computational needs, as well as privacy, availability, and real-time constraints, by providing local high-performance computing capabilities to deal with the limitations and constraints of cloud and embedded systems. Edge computing is today driven by strong market forces stemming from IT/cloud, telecom, and networking - with corresponding multiple interpretations of ”edge computing” (e.g. device edge, network edge, distributed cloud, etc.). Considering the strong drivers for edge-computing and the relative novelty of the field, it becomes important to understand the specific requirements and characteristics of edge-based CPS, and to ensure that research is guided adequately, e.g. avoiding specific gaps.Our interests lie in the applications of edge computing as part of CPS, where several properties (or attributes) of trustworthiness, including safety, security, and predictability/availability are of particular concern, each facing challenges for the introduction of edge-based CPS. We present the results of a systematic mapping study, a kind of systematic literature survey, investigating the use of edge computing for CPS with a special emphasis on trustworthiness. The main contributions of this study are a detailed description of the current research efforts in edge-based CPS and the identification and discussion of trends and research gaps. The results show that the main body of research in edge-based CPS only to a very limited extent consider key attributes of system trustworthiness, despite many efforts referring to critical CPS and applications like intelligent transportation. More research and industrial efforts will be needed on aspects of trustworthiness of future edge-based CPS including their experimental evaluation. Such research needs to consider the multiple interrelated attributes of trustworthiness including safety, security, and predictability, and new methodologies and architectures to address them. It is further important to provide bridges and collaboration between edge computing and CPS disciplines.
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| 10. |
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| 11. |
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| 12. |
- Jörgensen, Connie, et al.
(author)
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Ultrasound measurement of the fetal cerebral ventricles: a prospective, consecutive study
- 1986
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In: Journal of Clinical Ultrasound. - : Wiley. - 0091-2751 .- 1097-0096. ; 14:3, s. 185-190
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Journal article (peer-reviewed)abstract
- Real-time ultrasound was used in 654 consecutive pregnancies to obtain standard growth parameters for the fetal brain. Measurement of the width of the lateral ventricle (LVW) and hemisphere and their relationships to menstrual age, biparietal diameter, and birth weight were determined. The growth of the LVW was to a great extent independent of birth weight but dependent on menstrual age. Thirteen fetuses with a single ventricular width measurements exceeding +2 SD from the mean were separately evaluated, and all but one case were found to be normal.
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| 13. |
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| 14. |
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| 15. |
- Jörgensen, Nils, et al.
(author)
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RoboPlan5G : Coordinating Cloud-Controlled Mobile Robots with 5G Network Configuration
- 2023
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In: 2023 IEEE 28th International Conference on Emerging Technologies and Factory Automation, ETFA 2023. - : Institute of Electrical and Electronics Engineers (IEEE).
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Conference paper (peer-reviewed)abstract
- With the emergence of Industry 4.0, comes an increasing need for multi-robot coordination and communication to efficiently complete joint tasks. A critical technology is the fifth generation (5G) mobile network, which enables cloud-controlled robots to execute tasks with differentiated quality-of-service (QoS) features. While there has been significant research on multi-robot planning, the integration with the capabilities of realistic network systems has been limited. In this paper, we introduce RoboPlan5G, a framework for 5G-aware robot planning. We propose a joint state-search model that includes task planning coordination in conjunction with 5G physical resource block (PRB) allocation. This process ensures efficient usage of the limited indoor 5G spectrum and effective service performance, while still aiming for the completion of tasks in the shortest possible time frame. Scenarios are generated in an Industry 4.0 environment, where the planner is shown to decrease the required 5G spectrum allocation by 50%, and on average improve the plan quality by 45% while maintaining a small computation time.
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| 16. |
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| 17. |
- Jörgensen, Nils, et al.
(author)
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Towards 5G-Aware Robot Planning for Industrial Applications
- 2022
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In: 2022 IEEE 27th international conference on emerging technologies and factory automation (ETFA). - : Institute of Electrical and Electronics Engineers (IEEE).
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Conference paper (peer-reviewed)abstract
- With the emergence of Industry 4.0, comes an increasing need for multi-robot coordination and communication to efficiently complete joint tasks. A critical technology is the fifth generation (5G) mobile network, which enables multiple robots to execute control tasks with differentiated quality-of-service (QoS) features. However, there has been limited analysis of the impact of real 5G capabilities on multi-agent robot planning problems. In this paper, we provide a review of robot planning algorithms suitable for industrial use-cases, which consider communication aspects in the planning formulation. The paper is further positioned to identify gaps in existing state of the art within communication-aware planning. This is followed by an analysis of key challenges to be targeted at the intersection of 5G, Industry 4.0 and multi-agent robot planning. This analysis is strategically important and would prove useful to academic researchers and industry experts focusing on deployment of robots in industrial settings.
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| 18. |
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| 19. |
- Kaldo, Viktor, et al.
(author)
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Guided internet cognitive behavioral therapy for insomnia compared to a control treatment - A randomized trial
- 2015
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In: Behaviour Research and Therapy. - : Elsevier. - 0005-7967 .- 1873-622X. ; 71, s. 90-100
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Journal article (peer-reviewed)abstract
- Aim: To evaluate if internet-delivered Cognitive Behavioral Therapy for insomnia (ICBT-i) with brief therapist support outperforms an active control treatment. Method: Adults diagnosed with insomnia were recruited via media (n = 148) and randomized to either eight weeks of ICBT-i or an active internet-based control treatment. Primary outcome was the insomnia severity index (ISI) assessed before and after treatment, with follow-ups after 6 and 12 months. Secondary outcomes were use of sleep medication, sleep parameters (sleep diary), perceived stress, and a screening of negative treatment effects. Hierarchical Linear Mixed Models were used for intent-to-treat analyses and handling of missing data. Results: ICBT-i was significantly more effective than the control treatment in reducing ISI (Cohen's d = 0.85), sleep medication, sleep efficiency, sleep latency, and sleep quality at post-treatment. The positive effects were sustained. However, after 12 months the difference was no longer significant due to a continuous decrease in ISI among controls, possibly due to their significantly higher utilization of insomnia relevant care after treatment Forty-six negative effects were reported but did not differ between interventions. Conclusions: Supported ICBT-i is more effective than an active control treatment in reducing insomnia severity and treatment gains remain stable one year after treatment (C) 2015 The Authors. Published by Elsevier Ltd.
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| 20. |
- López, Aida Rodríguez, et al.
(author)
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Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
- 2023
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In: Cell Reports. - 2211-1247. ; 42:11, s. 1-23
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Journal article (peer-reviewed)abstract
- Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling, which involves alterations in protein and organelle homeostasis through autophagy. Here, we show that ribosomes are selectively targeted for degradation by autophagy during OIS. By characterizing senescence-dependent alterations in the ribosomal interactome, we find that the deubiquitinase USP10 dissociates from the ribosome during the transition to OIS. This release of USP10 leads to an enhanced ribosome ubiquitination, particularly of small subunit proteins, including lysine 275 on RPS2. Both reinforcement of the USP10-ribosome interaction and mutation of RPS2 K275 abrogate ribosomal delivery to lysosomes without affecting bulk autophagy. We show that the selective recruitment of ubiquitinated ribosomes to autophagosomes is mediated by the p62 receptor. While ribophagy is not required for the establishment of senescence per se, it contributes to senescence-related metabolome alterations and facilitates the senescence-associated secretory phenotype.
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| 21. |
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| 22. |
- Palm, Anders, et al.
(author)
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Svensk Skolordbok
- 1992
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Book (pop. science, debate, etc.)
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| 23. |
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| 24. |
- Sarris, Theodore E., et al.
(author)
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Daedalus MASE (mission assessment through simulation exercise): A toolset for analysis of in situ missions and for processing global circulation model outputs in the lower thermosphere-ionosphere
- 2023
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In: Frontiers in Astronomy and Space Sciences. - : Frontiers Media SA. - 2296-987X. ; 9
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Journal article (peer-reviewed)abstract
- Daedalus MASE (Mission Assessment through Simulation Exercise) is an open-source package of scientific analysis tools aimed at research in the Lower Thermosphere-Ionosphere (LTI). It was created with the purpose to assess the performance and demonstrate closure of the mission objectives of Daedalus, a mission concept targeting to perform in-situ measurements in the LTI. However, through its successful usage as a mission-simulator toolset, Daedalus MASE has evolved to encompass numerous capabilities related to LTI science and modeling. Inputs are geophysical observables in the LTI, which can be obtained either through in-situ measurements from spacecraft and rockets, or through Global Circulation Models (GCM). These include ion, neutral and electron densities, ion and neutral composition, ion, electron and neutral temperatures, ion drifts, neutral winds, electric field, and magnetic field. In the examples presented, these geophysical observables are obtained through NCAR’s Thermosphere-Ionosphere-Electrodynamics General Circulation Model. Capabilities of Daedalus MASE include: 1) Calculations of products that are derived from the above geophysical observables, such as Joule heating, energy transfer rates between species, electrical currents, electrical conductivity, ion-neutral collision frequencies between all combinations of species, as well as height-integrations of derived products. 2) Calculation and cross-comparison of collision frequencies and estimates of the effect of using different models of collision frequencies into derived products. 3) Calculation of the uncertainties of derived products based on the uncertainties of the geophysical observables, due to instrument errors or to uncertainties in measurement techniques. 4) Routines for the along-orbit interpolation within gridded datasets of GCMs. 5) Routines for the calculation of the global coverage of an in situ mission in regions of interest and for various conditions of solar and geomagnetic activity. 6) Calculations of the statistical significance of obtaining the primary and derived products throughout an in situ mission’s lifetime. 7) Routines for the visualization of 3D datasets of GCMs and of measurements along orbit. Daedalus MASE code is accompanied by a set of Jupyter Notebooks, incorporating all required theory, references, codes and plotting in a user-friendly environment. Daedalus MASE is developed and maintained at the Department for Electrical and Computer Engineering of the Democritus University of Thrace, with key contributions from several partner institutions.
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| 25. |
- Ström, Kristoffer, et al.
(author)
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N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
- 2018
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Journal article (peer-reviewed)abstract
- Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism. Nicotinamide N-methyltransferase (NNMT) was the most consistently upregulated gene following the energy-deficit exercise. Circulating levels of N1-methylnicotinamide (MNA), the product of NNMT activity, were doubled after the intervention. The fasting-fed state was an important determinant of plasma MNA levels, peaking at ~18 h of fasting and being lowest ~3 h after a meal. In culture, MNA was secreted by isolated human myotubes and stimulated lipolysis directly, with no effect on glucagon or insulin secretion. We propose that MNA is a novel myokine that enhances the utilization of energy stores in response to low muscle energy availability. Future research should focus on applying MNA as a biomarker to identify individuals with metabolic disturbances at an early stage.
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| 26. |
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