| 1. |
|
|
| 2. |
- Greer, M., et al.
(author)
-
Lung transplantation after allogeneic stem cell transplantation: a pan-European experience
- 2018
-
In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 51:2
-
Journal article (peer-reviewed)abstract
- Late-onset noninfectious pulmonary complications (LONIPCs) affect 6% of allogeneic stem cell transplantation (SCT) recipients within 5 years, conferring subsequent 5-year survival of 50%. Lung transplantation is rarely performed in this setting due to concomitant extrapulmonary morbidity, excessive immunosuppression and concerns about recurring malignancy being considered contraindications. This study assesses survival in highly selected patients undergoing lung transplantation for LONIPCs after SCT. SCT patients undergoing lung transplantation at 20 European centres between 1996 and 2014 were included. Clinical data pre- and post-lung transplantation were reviewed. Propensity score-matched controls were generated from the Eurotransplant and Scandiatransplant registries. Kaplan-Meier survival analysis and Cox proportional hazard regression models evaluating predictors of graft loss were performed. Graft survival at 1, 3 and 5 years of 84%, 72% and 67%, respectively, among the 105 SCT patients proved comparable to controls (p=0.75). Sepsis accounted for 15 out of 37 deaths (41%), with prior mechanical ventilation (HR 6.9, 95% CI 1.0-46.7; p<0.001) the leading risk factor. No SCT-specific risk factors were identified. Recurring malignancy occurred in four patients (4%). Lung transplantation <2 years post-SCT increased all-cause 1-year mortality (HR 7.5, 95% CI 2.3-23.8; p=0.001). Lung transplantation outcomes following SCT were comparable to other end-stage diseases. Lung transplantation should be considered feasible in selected candidates. No SCT-specific factors influencing outcome were identified within this carefully selected patient cohort.
|
|
| 3. |
- Knobler, R., et al.
(author)
-
Guidelines on the use of extracorporeal photopheresis
- 2014
-
In: Journal of the European Academy of Dermatology and Venereology. - : Wiley-Blackwell. - 0926-9959 .- 1468-3083. ; 28:s1, s. 1-37
-
Journal article (peer-reviewed)abstract
- BackgroundAfter the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma was published in 1983 with its subsequent recognition by the FDA for its refractory forms, the technology has shown significant promise in the treatment of other severe and refractory conditions in a multi-disciplinary setting. Among the major studied conditions are graft versus host disease after allogeneic bone marrow transplantation, systemic sclerosis, solid organ transplant rejection and inflammatory bowel disease. Materials and methodsIn order to provide recognized expert practical guidelines for the use of this technology for all indications the European Dermatology Forum (EDF) proceeded to address these questions in the hands of the recognized experts within and outside the field of dermatology. This was done using the recognized and approved guidelines of EDF for this task. Results and conclusionThese guidelines provide at present the most comprehensive available expert recommendations for the use of extracorporeal photopheresis based on the available published literature and expert consensus opinion.
|
|
| 4. |
- Rofors, E., et al.
(author)
-
Response of a Li-glass/multi-anode photomultiplier detector to focused proton and deuteron beams
- 2020
-
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 984
-
Journal article (peer-reviewed)abstract
- The response of a position-sensitive Li-glass based scintillation detector being developed for thermal-neutron detection with 6 mm position resolution has been investigated using focused beams of 2.5MeV protons and deuterons. The beams were scanned across the detector in 0.5 mm horizontal and vertical steps perpendicular to the beams. Scintillation light was registered using an 8 × 8 pixel multi-anode photomultiplier tube. The signal amplitudes were recorded for each pixel on an event-by-event basis. Several pixels generally registered considerable signals at each beam location. To optimize planned detector operation at the European Spallation Source, the number of pixels above set thresholds was investigated, with the maximization of the single-hit efficiency over the largest possible area as the primary goal. For both beams, at a threshold of ∼50% of the mean of the full-deposition peak, ∼80% of the events were registered in a single pixel, resulting in an effective position resolution of ∼5 mm in X and Y. Lower thresholds resulted in higher pixel multiplicities. These events could also be localized with the same effective position resolution.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Rivière, A., et al.
(author)
-
Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis: A cohort study
- 2022
-
In: American Journal of Transplantation. - : Elsevier BV. - 1600-6135. ; 22:12, s. 2990-3001
-
Journal article (peer-reviewed)abstract
- In patients with interstitial lung disease (ILD) complicating classical or amyopathic idiopathic inflammatory myopathy (IIM), lung transplantation outcomes might be affected by the disease and treatments. Here, our objective was to assess survival and prognostic factors in lung transplant recipients with IIM-ILD. We retrospectively reviewed data for 64 patients who underwent lung transplantation between 2009 and 2021 at 19 European centers. Patient survival was the primary outcome. At transplantation, the median age was 53 [46–59] years, 35 (55%) patients were male, 31 (48%) had classical IIM, 25 (39%) had rapidly progressive ILD, and 21 (33%) were in a high-priority transplant allocation program. Survival rates after 1, 3, and 5 years were 78%, 73%, and 70%, respectively. During follow-up (median, 33 [7–63] months), 23% of patients developed chronic lung allograft dysfunction. Compared to amyopathic IIM, classical IIM was characterized by longer disease duration, higher-intensity immunosuppression before transplantation, and significantly worse posttransplantation survival. Five (8%) patients had a clinical IIM relapse, with mild manifestations. No patient experienced ILD recurrence in the allograft. Posttransplantation survival in IIM-ILD was similar to that in international all-cause-transplantation registries. The main factor associated with worse survival was a history of muscle involvement (classical IIM). In lung transplant recipients with idiopathic inflammatory myopathy, survival was similar to that in all-cause transplantation and was worse in patients with muscle involvement compared to those with the amyopathic disease. © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
|
|
| 10. |
- Rofors, E., et al.
(author)
-
Response of a Li-glass/multi-anode photomultiplier detector to collimated thermal-neutron beams
- 2021
-
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 999
-
Journal article (peer-reviewed)abstract
- The response of a position-sensitive Li-glass scintillator detector being developed for thermal-neutron detection with 6 mm position resolution has been investigated using collimated beams of thermal neutrons. The detector was moved perpendicularly through the neutron beams in 0.5 to 1.0 mm horizontal and vertical steps. Scintillation was detected in an 8 × 8 pixel multi-anode photomultiplier tube on an event-by-event basis. In general, several pixels registered large signals at each neutron-beam location. The number of pixels registering signal above a set threshold was investigated, with the maximization of the single-hit efficiency over the largest possible area of the detector as the primary goal. At a threshold of ∼50% of the mean of the full-deposition peak, ∼80% of the events were registered in a single pixel, resulting in an effective position resolution of ∼5 mm in X and Y. Lower thresholds generally resulted in events demonstrating higher pixel multiplicities, but these events could also be localized with ∼5 mm position resolution.
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Graham, A.C., et al.
(author)
-
0.7 Analogue structures and exchange interactions in quantum wires
- 2004
-
In: Solid State Communications. - : Elsevier BV. - 0038-1098 .- 1879-2766. ; 131:9-10 SPEC. ISS., s. 591-597
-
Journal article (peer-reviewed)abstract
- We present experimental studies of crossings of spin-split one-dimensional subbands in ballistic quantum wires in an in-plane magnetic field B ?. At low electron densities, a spontaneous spin-splitting occurs as subbands cross, which gives rise to additional non-quantised conductance structures called 0.7 analogues. We analyse the data within a spin-density-functional model, which includes exchange interactions in a magnetic field. Focussing on the region of the crossings of spin-split subbands, it is found that the energy levels rearrange as they cross due to exchange interactions. © 2004 Elsevier Ltd. All rights reserved.
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Knobler, R., et al.
(author)
-
European dermatology forum : Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2
- 2021
-
In: Journal of the European Academy of Dermatology and Venereology. - : Wiley-Blackwell Publishing Inc.. - 0926-9959 .- 1468-3083. ; 35:1, s. 27-49
-
Journal article (peer-reviewed)abstract
- BackgroundFollowing the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T‐cell lymphoma published in 1983, this technology has received continued use and further recognition for additional earlier as well as refractory forms. After the publication of the first guidelines for this technology in the JEADV in 2014, this technology has maintained additional promise in the treatment of other severe and refractory conditions in a multidisciplinary setting. It has confirmed recognition in well‐known documented conditions such as graft‐vs.‐host disease after allogeneic bone marrow transplantation, systemic sclerosis, solid organ transplant rejection including lung, heart and liver and to a lesser extent inflammatory bowel disease.Materials and methodsIn order to further provide recognized expert practical guidelines for the use of this technology for all indications, the European Dermatology Forum (EDF) again proceeded to address these questions in the hands of the recognized experts within and outside the field of dermatology. This was done using the recognized and approved guidelines of EDF for this task. All authors had the opportunity to review each contribution as it was added.Results and conclusionThese updated 2020 guidelines provide at present the most comprehensive available expert recommendations for the use of extracorporeal photopheresis based on the available published literature and expert consensus opinion. The guidelines were divided into two parts: PART I covers Cutaneous T‐cell lymphoma, chronic graft‐vs.‐host disease and acute graft‐vs.‐host disease, while PART II will cover scleroderma, solid organ transplantation, Crohn’s disease, use of ECP in paediatric patients, atopic dermatitis, type 1 diabetes, pemphigus, epidermolysis bullosa acquisita and erosive oral lichen planus.
|
|
| 19. |
- Knobler, R., et al.
(author)
-
European dermatology forum - updated guidelines on the use of extracorporeal photopheresis 2020-part 1
- 2020
-
In: Journal of the European Academy of Dermatology and Venereology. - : WILEY. - 0926-9959 .- 1468-3083. ; 34:12, s. 2693-2716
-
Journal article (peer-reviewed)abstract
- Background Following the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma published in 1983, this technology has received continued use and further recognition for additional earlier as well as refractory forms. After the publication of the first guidelines for this technology in the JEADV in 2014, this technology has maintained additional promise in the treatment of other severe and refractory conditions in a multi-disciplinary setting. It has confirmed recognition in well-known documented conditions such as graft-versus-host disease after allogeneic bone marrow transplantation, systemic sclerosis, solid organ transplant rejection including lung, heart and liver and to a lesser extent inflammatory bowel disease. Materials and methods In order to further provide recognized expert practical guidelines for the use of this technology for all indications, the European Dermatology Forum (EDF) again proceeded to address these questions in the hands of the recognized experts within and outside the field of dermatology. This was done using the recognized and approved guidelines of EDF for this task. All authors had the opportunity to review each contribution as it was added. Results and conclusion These updated 2020 guidelines provide at present the most comprehensive available expert recommendations for the use of extracorporeal photopheresis based on the available published literature and expert consensus opinion. The guidelines are divided in two parts: PART I covers cutaneous T-cell lymphoma, chronic graft-versus-host disease and acute graft-versus-host disease while PART II will cover scleroderma, solid organ transplantation, Crohns disease, use of ECP in paediatrics practice, atopic dermatitis, type 1 diabetes, pemphigus, epidermolysis bullosa acquisita and erosive oral lichen planus.
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
- Sumitran-Holgersson, S, et al.
(author)
-
Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas
- 2009
-
In: Cell transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 18:2, s. 183-193
-
Journal article (peer-reviewed)abstract
- Although the appearance of hepatic foci in the pancreas has been described in animal experiments and in human pathology, evidence for the conversion of human pancreatic cells to liver cells is still lacking. We therefore investigated the developmental plasticity between human embryonic pancreatic cells and liver cells. Cells were isolated and expanded from 7–8-week-old human fetal pancreata (HFP) and were characterized for the absence and presence of pancreatic and hepatic markers. In vitro expanded HFP were treated with fibroblast growth factor 2 (FGF2) and dexamethasone (DX) to induce a liver phenotye in the cells. These treated cells in various passages were further studied for their capacity to be functional in hepatic parenchyma following retrorsine-induced injury in nude C57 black mice. Amylase- and EPCAM-positive-enriched cells isolated from HFP and treated with FGF2 and DX lost expression of pancreatic markers and gained a liver phenotype. Hepatic differentiation was based on the expression (both at the mRNA and protein level) of liver markers albumin and cytokeratin 19. When transplanted in vivo into nude mice treated with retrorsine, both cell types successfully engrafted and functionally differentiated into hepatic cells expressing human albumin, glycogen, dipeptidyl peptidase, and γ-glutamyltranspeptidase. These data indicate that human fetal pancreatic cells have a capacity to alter their gene expression profile in response to exogenous treatment with FGF2 and DX. It may be possible to generate an unlimited supply of hepatocytes in vitro for cell therapy.
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
- Jaksch, Peter, 1978-
(author)
-
Interactions, initial states, and low-dimensional semiconductors
- 2006
-
Doctoral thesis (other academic/artistic)abstract
- This thesis is concerned with different aspects of quantum mechanical interactions. The first part of the thesis focuses on their effects in low-dimensional semiconductors; the second part on one of their applications: quantum algorithms, which utilize superpositions created from quantum mechanical interactions. Bridging the gap between these two slightly different areas is a method for implementing quantum gates using interactions in low-dimensional semiconductors. We address the issue of dimensionality by studying the local density of states in a quantum point contact (QPC). This is important since many results regarding electron transport through the QPC rely on as assumption of one-dimensionality. We show that in order for this assumption to be valid, certain conditions regarding the shape of the potential have to be fulfilled (Paper I). We also study electron transport in quantum wires and QPCs, with emphasis on electron-electron interaction effects, using Density Functional Theory (DFT). In Paper II we provide an explanation of the experimentally observed 0.7 analogues in quantum wires in strong magnetic fields. We show that their origin is intimately linked with the exchange-correlation energy, and is thus as spin polarization phenomenon. In Paper III we analyze the conductance properties of QPCs and claim that spontaneous spin polarization is the driving mechanism behind the 0.7 anomaly in long QPCs. We also investigate the validity of the "Reilly model", and extend the study to nonzero temperature. Furthermore, we investigate the trapping of spin-polarized electrons in edge states around a pair of antidots (Paper IV). This study supports a proposal for using the trapped electrons to realize quantum gates – the building blocks of a quantum computer. The main advantage of our proposal is that the edge states have a very long lifetime, which will reduce problems with decoherence. Papers V and VI, finally, are concerned with quantum algorithms for initial state preparation. In Paper V a method is devised for preparing initial states for quantum eigenvalue calculation; it is based on a scheme for extending the size of a quantum register through duplication of its quantum bits (qubits). The central result in Paper VI is an algorithm for preparing initial states for quantum simulation. The state to be prepared is chosen as an eigenstate, with eigenvalu 0, of some quantum system, on which eigenvalue calculation is performed using the method in Paper V.
|
|
| 26. |
- Kanaki, K., et al.
(author)
-
Detector rates for the Small Angle Neutron Scattering instruments at the European Spallation Source
- 2018
-
In: Journal of Instrumentation. - 1748-0221. ; 13:7
-
Journal article (peer-reviewed)abstract
- Building the European Spallation Source (ESS), the most powerful neutron source in the world, requires significant technological advances at most fronts of instrument component design. Detectors are not an exception. The existing implementations at current neutron scattering facilities are at their performance limits and sometimes barely cover the scientific needs. At full operation the ESS will yield unprecedented neutron brilliance. This means that one of the most challenging aspects for the new detector designs is the increased rate capability and in particular the peak instantaneous rate capability, i.e. the number of neutrons hitting the detector per channel, pixel or cm2 at the peak of the neutron pulse. This paper focuses on estimating the incident and detection rates that are anticipated for the Small Angle Neutron Scattering (SANS) instruments planned for ESS. Various approaches are applied and the results thereof are presented.
|
|
| 27. |
- Rofors, E., et al.
(author)
-
Response of a Li-glass/multi-anode photomultiplier detector to alpha-particles from Am-241
- 2019
-
In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 929, s. 90-96
-
Journal article (peer-reviewed)abstract
- The response of a position-sensitive Li-glass scintillator detector to alpha-particles from a collimated Am-241 source scanned across the face of the detector has been measured. Scintillation light was read out by an 8 x 8 pixel multi-anode photomultiplier and the signal amplitude for each pixel has been recorded for every position on a scan. The pixel signal is strongly dependent on position and in general several pixels will register a signal (a hit) above a given threshold. The effect of this threshold on hit multiplicity is studied, with a view to optimize the single-hit efficiency of the detector.
|
|
| 28. |
- Rofors, E., et al.
(author)
-
Response of a Li-glass/multi-anode photomultiplier detector to α-particles from 241 Am
- 2019
-
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 929, s. 90-96
-
Journal article (peer-reviewed)abstract
- The response of a position-sensitive Li-glass scintillator detector to α-particles from a collimated 241 Am source scanned across the face of the detector has been measured. Scintillation light was read out by an 8 × 8 pixel multi-anode photomultiplier and the signal amplitude for each pixel has been recorded for every position on a scan. The pixel signal is strongly dependent on position and in general several pixels will register a signal (a hit) above a given threshold. The effect of this threshold on hit multiplicity is studied, with a view to optimize the single-hit efficiency of the detector.
|
|
| 29. |
|
|
| 30. |
|
|
