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| 4. |
- Anttila, V., et al.
(author)
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Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
- 2023
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In: Molecular Therapy. - : Elsevier BV. - 1525-0016. ; 31:3, s. 866-874
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Journal article (peer-reviewed)abstract
- Vascular endothelial growth factor A (VEGF-A) has therapeutic cardiovascular effects, but delivery challenges have impeded clinical development. We report the first clinical study of naked mRNA encoding VEGF-A (AZD8601) injected into the human heart. EPICCURE (ClinicalTrials.gov: NCT03370887) was a randomized, double-blind study of AZD8601 in patients with left ventricular ejection fraction (LVEF) 30%–50% who were undergoing elective coronary artery bypass surgery. Thirty epicardial injections of AZD8601 (total 3 mg) or placebo in citrate-buffered saline were targeted to ischemic but viable myocardial regions mapped using quantitative [15O]-water positron emission tomography. Seven patients received AZD8601 and four received placebo and were followed for 6 months. There were no deaths or treatment-related serious adverse events and no AZD8601-associated infections, immune reactions, or arrhythmias. Exploratory outcomes indicated potential improvement in LVEF, Kansas City Cardiomyopathy Questionnaire scores, and N-terminal pro-B-type natriuretic peptide levels, but the study is limited in size, and significant efficacy conclusions are not possible from the dataset. Naked mRNA without lipid encapsulation may provide a safe delivery platform for introducing genetic material to cardiac muscle, but further studies are needed to confirm efficacy and safety in a larger patient pool. © 2022
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| 5. |
- Barbu, Mikael, et al.
(author)
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Serum biomarkers of brain injury after uncomplicated cardiac surgery: Secondary analysis from a randomized trial
- 2022
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In: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 66:4, s. 447-453
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Journal article (peer-reviewed)abstract
- Background: Postoperative cognitive dysfunction is common after cardiac surgery. Postoperative measurements of brain injury biomarkers may identify brain damage and predict cognitive dysfunction. We describe the release patterns of five brain injury markers in serum and plasma after uncomplicated cardiac surgery. Methods: Sixty-one elective cardiac surgery patients were randomized to undergo surgery with either a dextran-based prime or a crystalloid prime. Blood samples were taken immediately before surgery, and 2 and 24h after surgery. Concentrations of the brain injury biomarkers S100B, glial fibrillary acidic protein (GFAP), tau, neurofilament light (NfL) and neuron-specific enolase (NSE)) and the blood–brain barrier injury marker β-trace protein were analyzed. Concentrations of brain injury biomarkers were correlated to patients’ age, operation time, and degree of hemolysis. Results: No significant difference in brain injury biomarkers was observed between the prime groups. All brain injury biomarkers increased significantly after surgery (tau +456% (25th–75th percentile 327%−702%), NfL +57% (28%−87%), S100B +1145% (783%−2158%), GFAP +17% (−3%−43%), NSE +168% (106%−228%), while β-trace protein was reduced (−11% (−17−3%). Tau, S100B, and NSE peaked at 2h, NfL and GFAP at 24h. Postoperative concentrations of brain injury markers correlated to age, operation time, and/or hemolysis. Conclusion: Uncomplicated cardiac surgery with cardiopulmonary bypass is associated with an increase in serum/plasma levels of all the studied injury markers, without signs of blood–brain barrier injury. The biomarkers differ markedly in their levels of release and time course. Further investigations are required to study associations between perioperative release of biomarkers, postoperative cognitive function and clinical outcome. © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
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| 6. |
- Bengmark, S., et al.
(author)
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NEUESTER STAND DER LEBERCHIRURGIE
- 1982
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In: Zentralblatt fur Chirurgie. - 0044-409X. ; 107:12, s. 689-696
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Journal article (peer-reviewed)
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| 9. |
- Deb, S., et al.
(author)
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SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449)
- 2019
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In: Journal of Cardiothoracic Surgery. - : Springer Science and Business Media LLC. - 1749-8090. ; 14
-
Journal article (peer-reviewed)abstract
- BackgroundSingle centre studies support No Touch (NT) saphenous vein graft (SVG) harvesting technique. The primary objective of the SUPERIOR SVG study was to determine whether NT versus conventional (CON) SVG harvesting was associated with improved SVG patency 1year after coronary artery bypass grafting surgery (CABG).MethodsAdults undergoing isolated CABG with at least 1 SVG were eligible. CT angiography was performed 1-year post CABG. Leg adverse events were assessed with a questionnaire. A systematic review was performed for published NT graft patency studies and results aggregated including the SUPERIOR study results.ResultsTwo hundred and-fifty patients were randomized across 12-centres (NT 127 versus CON 123 patients). The primary outcome (study SVG occlusion or cardiovascular (CV) death) was not significantly different in NT versus CON (NT: 7/127 (5.5%), CON 13/123 (10.6%), p=0.15). Similarly, the proportion of study SVGs with significant stenosis or total occlusion was not significantly different between groups (NT: 8/102 (7.8%), CON: 16/107 (15.0%), p=0.11). Vein harvest site infection was more common in the NT patients 1month postoperatively (23.3% vs 9.5%, p<0.01). Including this study's results, in a meta-analysis, NT was associated with a significant reduction in SVG occlusion, Odds Ratio 0.49, 95% Confidence Interval 0.29-0.82, p=0.007 in 3 randomized and 1 observational study at 1year postoperatively.ConclusionsThe NT technique was not associated with improved patency of SVGs at 1-year following CABG while early vein harvest infection was increased. The aggregated data is supportive of an important reduction of SVG occlusion at 1year with NT harvesting.Trial registrationNCT01047449.
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| 11. |
- Feldman, H., et al.
(author)
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Assessing the effects of intra-granule precipitation in a full-scale industrial anaerobic digester
- 2019
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In: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 79:7, s. 1327-1337
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Journal article (peer-reviewed)abstract
- In this paper, a multi-scale model is used to assess the multiple mineral precipitation potential in a full-scale anaerobic granular sludge system. Reactor behaviour is analysed under different operational conditions (addition/no addition of reject water from dewatering of lime-stabilized biomass) and periods of time (short/long term). Model predictions suggest that a higher contribution of reject water promotes the risk of intra-granule CaCO3 formation as a result of the increased quantity of calcium arriving with that stream combined with strong pH gradients within the biofilm. The distribution of these precipitates depends on: (i) reactor height; and (ii) granule size. The study also exposes the potential undesirable effects of the long-term addition of reject water (a decrease in energy recovery of 20% over a 100-day period), caused by loss in biomass activity (due to microbial displacement), and the reduced buffer capacity. This demonstrates how both short-term and long-term operational conditions may affect the formation of precipitates within anaerobic granules, and how it may influence methane production and consequently energy recovery.
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| 12. |
- Feldman, H, et al.
(author)
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Modelling an industrial anaerobic granular reactor using a multi-scale approach
- 2017
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In: Water Research. - : Elsevier BV. - 0043-1354. ; 126, s. 488-500
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Journal article (peer-reviewed)abstract
- The objective of this paper is to show the results of an industrial project dealing with modelling of anaerobic digesters. A multi-scale mathematical approach is developed to describe reactor hydrodynamics, granule growth/distribution and microbial competition/inhibition for substrate/space within the biofilm. The main biochemical and physico-chemical processes in the model are based on the Anaerobic Digestion Model No 1 (ADM1) extended with the fate of phosphorus (P), sulfur (S) and ethanol (Et−OH). Wastewater dynamic conditions are reproduced and data frequency increased using the Benchmark Simulation Model No 2 (BSM2) influent generator. All models are tested using two plant data sets corresponding to different operational periods (#D1, #D2). Simulation results reveal that the proposed approach can satisfactorily describe the transformation of organics, nutrients and minerals, the production of methane, carbon dioxide and sulfide and the potential formation of precipitates within the bulk (average deviation between computer simulations and measurements for both #D1, #D2 is around 10%). Model predictions suggest a stratified structure within the granule which is the result of: 1) applied loading rates, 2) mass transfer limitations and 3) specific (bacterial) affinity for substrate. Hence, inerts (XI) and methanogens (Xac) are situated in the inner zone, and this fraction lowers as the radius increases favouring the presence of acidogens (Xsu,Xaa, Xfa) and acetogens (Xc4,Xpro). Additional simulations show the effects on the overall process performance when operational (pH) and loading (S:COD) conditions are modified. Lastly, the effect of intra-granular precipitation on the overall organic/inorganic distribution is assessed at: 1) different times; and, 2) reactor heights. Finally, the possibilities and opportunities offered by the proposed approach for conducting engineering optimization projects are discussed.
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| 13. |
- Flores-Alsina, X., et al.
(author)
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Evaluation of anaerobic digestion post-treatment options using an integrated model-based approach
- 2019
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In: Water Research. - : Elsevier BV. - 0043-1354. ; 156, s. 264-276
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Journal article (peer-reviewed)abstract
- The objective of this paper is to present the main results of an engineering-research project dealing with model-based evaluation of waste streams treatment from a biotech company. This has been extensively done in domestic treatment systems, but is equally important, and with different challenges in industrial wastewater treatment. A new set of biological (activated sludge, anaerobic digestion), physicochemical (aqueous phase, precipitation, mass transfer) process models and model interfaces are required to describe removal of organics in an upflow anaerobic sludge blanket (UASB) reactor plus either traditional nitrification/denitrification (A 1 ) or partial nitritation (PN)/anammox (ANX) (A 2 ) processes. Model-based analysis shows that option A 1 requires a decrease in digestion energy recovery (E recovery ) in order to have enough organic substrate for subsequent post NO 3 reduction treatment (95 kWh.kg N −1 ). In contrast, A 2 in an aerobic granular sludge reactor allows for higher UASB conversion since N removal is carried out autotrophically. The study also reveals that the addition of an aerated pre-treatment unit prior to the PN/ANX (A 2 ) reactor promotes COD and H 2 S oxidation, CO 2 and CH 4 stripping, a pH increase (up to 8.5) and a reduction of the risk of intra-granular precipitation as well as sulfide inhibition. Simulations indicate clear differences regarding the microbial distribution/abundance within the biofilm in A 2 when comparing the two operational modes. Final results show the effects of different loading and operational conditions; dissolved oxygen (DO), Total Suspended Solids (TSS op ), energy recovery (E recovery ); on the overall process performance; N removal, aeration energy (E aeration ), net energy production (E recovery ); using response surfaces, highlighting the need of integrated approaches to avoid sub-optimal outcomes. The study shows the benefits of virtual plant simulation and demonstrates the potential of model-based evaluation when process engineers in industry have to decide between competing options.
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| 14. |
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| 15. |
- Forsberg, Ulrika, et al.
(author)
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First Experiment at TASCA Towards X-Ray Fingerprinting of Element 115 Decay Chains
- 2012
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In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 43:2, s. 305-311
-
Journal article (peer-reviewed)abstract
- To identify the atomic number of superheavy nuclei produced in Ca-48-induced fusion-evaporation reactions, an experiment aiming at measuring characteristic X-rays is being prepared at GSI, Darmstadt, Germany. The gas-filled separator TASCA will be employed, sending the residues towards the multi-coincidence detector setup TASISpec. Two ion-optical modes relying on differing magnetic polarities of the quadrupole magnets can be used at TASCA. New simulations and experimental tests of transmission and background suppression for these two focusing modes into TASISpec are presented.
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| 16. |
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| 17. |
- Jeppsson, K, et al.
(author)
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Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
- 2022
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In: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:23, s. eabn7063-
-
Journal article (peer-reviewed)abstract
- Genome function depends on regulated chromosome folding, and loop extrusion by the protein complex cohesin is essential for this multilayered organization. The chromosomal positioning of cohesin is controlled by transcription, and the complex also localizes to stalled replication forks. However, the role of transcription and replication in chromosome looping remains unclear. Here, we show that reduction of chromosome-bound RNA polymerase weakens normal cohesin loop extrusion boundaries, allowing cohesin to form new long-range chromosome cis interactions. Stress response genes induced by transcription inhibition are also shown to act as new loop extrusion boundaries. Furthermore, cohesin loop extrusion during early S phase is jointly controlled by transcription and replication units. Together, the results reveal that replication and transcription machineries are chromosome-folding regulators that block the progression of loop-extruding cohesin, opening for new perspectives on cohesin’s roles in genome function and stability.
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| 23. |
- Nilsson, K, et al.
(author)
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A General Method for the Immobilization of Cells with Preserved Viability
- 1983
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In: Applied Microbiology and Biotechnology. ; 17, s. 319-326
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Journal article (peer-reviewed)abstract
- Microbial, algal, plant and animal cells have been immobilized, with preserved viability, by entrapment in various matrices according to a new bead polymerization technique. The cell polymer/monomer mixture is kept suspended in a hydrophobic phase such as soy, paraffin, or silicon oil, tri-n-butylphosphate, or dibutyphtalate, which is compatible with the cells. The various monomers or polymers tested include agarose, agar, carrageenan, alginate, fibrin, and polyacrylamide. Furthermore, by adjustment of the stirring speed of the suspension, beads of desired diameter can easily be obtained. The entrapped cells are fully viable and biosynthetically active.
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| 24. |
- Nygård, K., et al.
(author)
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ForMAX – a beamline for multiscale and multimodal structural characterization of hierarchical materials
- 2024
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In: Journal of Synchrotron Radiation. - : International Union of Crystallography (IUCr). - 0909-0495 .- 1600-5775. ; 31:Pt 2, s. 363-377
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Journal article (peer-reviewed)abstract
- The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nanometre to millimetre range by combining small- and wide-angle X-ray scattering with full-field microtomography. The modular design of the beamline is optimized for easy switching between different experimental modalities. The beamline has a special focus on the development of novel fibrous materials from forest resources, but it is also well suited for studies within, for example, food science and biomedical research.
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| 25. |
- Solon, K., et al.
(author)
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Plant-wide modelling of phosphorus transformations in wastewater treatment systems : Impacts of control and operational strategies
- 2017
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In: Water Research. - : Elsevier BV. - 0043-1354. ; 113, s. 97-110
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Journal article (peer-reviewed)abstract
- The objective of this paper is to report the effects that control/operational strategies may have on plant-wide phosphorus (P) transformations in wastewater treatment plants (WWTP). The development of a new set of biological (activated sludge, anaerobic digestion), physico-chemical (aqueous phase, precipitation, mass transfer) process models and model interfaces (between water and sludge line) were required to describe the required tri-phasic (gas, liquid, solid) compound transformations and the close interlinks between the P and the sulfur (S) and iron (Fe) cycles. A modified version of the Benchmark Simulation Model No. 2 (BSM2) (open loop) is used as test platform upon which three different operational alternatives (A1, A2, A3) are evaluated. Rigorous sensor and actuator models are also included in order to reproduce realistic control actions. Model-based analysis shows that the combination of an ammonium (SNHX ) and total suspended solids (XTSS) control strategy (A1) better adapts the system to influent dynamics, improves phosphate (SPO4 ) accumulation by phosphorus accumulating organisms (XPAO) (41%), increases nitrification/denitrification efficiency (18%) and reduces aeration energy (Eaeration) (21%). The addition of iron XFeCl3 ) for chemical P removal (A2) promotes the formation of ferric oxides (XHFO−H, XHFO−L), phosphate adsorption (XHFO−H,P, XHFO−L,P), co-precipitation (XHFO−H,P,old, XHFO−L,P,old) and consequently reduces the P levels in the effluent (from 2.8 to 0.9 g P.m−3). This also has an impact on the sludge line, with hydrogen sulfide production (GH2S) reduced (36%) due to iron sulfide (XFeS) precipitation. As a consequence, there is also a slightly higher energy production (Eproduction) from biogas. Lastly, the inclusion of a stripping and crystallization unit (A3) for P recovery reduces the quantity of P in the anaerobic digester supernatant returning to the water line and allows potential struvite (XMgNH4PO4 ) recovery ranging from 69 to 227 kg.day−1 depending on: (1) airflow (Qstripping); and, (2) magnesium (QMg(OH)2 ) addition. All the proposed alternatives are evaluated from an environmental and economical point of view using appropriate performance indices. Finally, some deficiencies and opportunities of the proposed approach when performing (plant-wide) wastewater treatment modelling/engineering projects are discussed.
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| 26. |
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| 27. |
- Barbu, Mikael, et al.
(author)
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Hemostatic effects of a dextran-based priming solution for cardiopulmonary bypass: A secondary analysis of a randomized clinical trial
- 2023
-
In: Thrombosis Research. - : Elsevier BV. - 0049-3848. ; 223, s. 139-145
-
Journal article (peer-reviewed)abstract
- Introduction: Intravascular fluids administered to patients may influence hemostasis. In patients undergoing cardiac surgery with cardiopulmonary bypass, the heart-lung machine is primed with 1300 ml of fluid. We assessed postoperative coagulation and platelet function in patients randomized to two different priming solu-tions, one colloid-based (dextran 40) and one crystalloid-based.Materials and methods: Eighty-four elective cardiac surgery patients were randomized to either a dextran-based prime or Ringer's acetate with added mannitol. Blood samples were collected before, and 2 and 24 h after cardiopulmonary bypass. Coagulation was assessed by standard coagulation tests and rotational thromboelas-tometry. Platelet function was assessed with impedance aggregometry. Bleeding volumes and transfusion re-quirements were recorded.Results: Comparing the groups 2 h after bypass, the dextran group showed lower hemoglobin concentration, hematocrit, platelet count, and fibrinogen concentration, and higher INR and aPTT, as well as longer clot for-mation time (+41 +/- 21 % vs. +8 +/- 18 %, p < 0.001) and a larger reduction in fibrinogen-dependent clot strength (-37 +/- 12 % vs.-7 +/- 20 %, p < 0.001). Adenosine diphosphate-dependent platelet activation was reduced in the dextran group but not in the crystalloid group 2 h after bypass (-14 +/- 29 % vs.-1 +/- 41 %, p = 0.041). No significant between-group differences in hemostatic variables remained after 24 h, and no significant differences in perioperative bleeding volumes, re-explorations for bleeding, or transfusion rates were observed.Conclusions: Compared to a crystalloid solution, a dextran-based prime had measurable negative impact on he-mostatic variables but no detectable increase in bleeding volume or transfusion requirements in cardiac surgery patients.
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| 28. |
- Benazzi, F, et al.
(author)
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On-line estimation and detection of abnormal substrate concentrations in WWTPs using a software sensor: A benchmark study
- 2007
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In: Environmental Technology. - 1479-487X. ; 28:8, s. 871-882
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Journal article (peer-reviewed)abstract
- In this paper, a new approach for on-line monitoring and detection of abnormal readily biodegradable substrate (SS) and slowly biodegradable substrate (XS) concentrations, for example due to input of toxic loads from the sewer, or due to influent substrate shock load, is proposed. Considering that measurements of SS and XS concentrations are not available in real wastewater treatment plants, the SS | XS software sensor can activate an alarm with a response time of about 60 and 90 minutes, respectively, based on the dissolved oxygen measurement. The software sensor implementation is based on an extended Kalman filter observer and disturbances are modelled using fast Fourier transform and spectrum analyses. Three case studies are described. The first one illustrates the fast and accurate convergence of the extended Kalman filter algorithm, which is achieved in less than 2 hours. Furthermore, the difficulties of estimating XS when off-line analysis is not available are depicted, and the SS | XS software sensor performances when no measurements of SS and XS are available are illustrated. Estimation problems related to the death-regeneration concept of the activated sludge model no.1 and possible application of the software sensor in wastewater monitoring are discussed.
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| 29. |
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| 30. |
- Calner, Mikael, et al.
(author)
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An atypical intra-platform environment and biota from the Silurian of Gotland, Sweden
- 2008
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In: GFF. - 2000-0863. ; 130:Part 2, s. 79-86
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Journal article (peer-reviewed)abstract
- A condensed shale from the middle Silurian of Gotland (Sweden) is herein described with regard to its biotic and environmental significance. The fauna is characterised by an overall low diversity and anomalous abundance patterns, notably a mass-occurrence of scolecodonts. Other elements include abundant chitinozoans, dendroid and graptoloid graptolites, conodonts, eurypterids, and the brachiopod Lingula. An unusually good collection of the rare, minute conodont Aldridgeodus minimus gen. et sp. nov., was recovered and is therefore formally described herein. The conspicuous faunal composition and palaeogeographical position of the shale in the interior area of a carbonate platform is unique for any stratum of Gotland and may represent a rarely preserved environment for the lower Palaeozoic.
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| 31. |
- Challis, K, et al.
(author)
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Gestational diabetes mellitus and fetal death in Mozambique: an incident case-referent study
- 2002
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In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 81:6, s. 560-563
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Journal article (peer-reviewed)abstract
- Background. Third trimester fetal death is a common problem in Mozambique, occurring in approximately 5% of parturient women. Objective. To elucidate the magnitude of the gestational diabetes mellitus problem, and to estimate its prevalence in a group of women with unexplained late fetal deaths and in women with live fetuses (referents). Methods. An incident case-referent study of 109 pregnant Mozambican women with fetal deaths and 110 women delivering liveborns, regarding fasting B-glucose, oral glucose tolerance test and glycosylated hemoglobin. Result. The difference in gestational diabetes mellitus prevalence in the two groups is not significant. The prevalence of gestational diabetes mellitus was high in both groups: 11% and 7%, respectively.
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| 32. |
- Chung, Sheng-Chia, et al.
(author)
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Acute myocardial infarction : a comparison of short-term survival in national outcome registries in Sweden and the UK
- 2014
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 383:9925, s. 1305-1312
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Journal article (peer-reviewed)abstract
- Background International research for acute myocardial infarction lacks comparisons of whole health systems. We assessed time trends for care and outcomes in Sweden and the UK. Methods We used data from national registries on consecutive patients registered between 2004 and 2010 in all hospitals providing care for acute coronary syndrome in Sweden and the UK. The primary outcome was all-cause mortality 30 days after admission. We compared effectiveness of treatment by indirect casemix standardisation. This study is registered with ClinicalTrials.gov, number NCT01359033. Findings We assessed data for 119 786 patients in Sweden and 391 077 in the UK. 30-day mortality was 7.6% (95% CI 7.4-7.7) in Sweden and 10.5% (10.4-10.6) in the UK. Mortality was higher in the UK in clinically relevant subgroups defined by troponin concentration, ST-segment elevation, age, sex, heart rate, systolic blood pressure, diabetes mellitus status, and smoking status. In Sweden, compared with the UK, there was earlier and more extensive uptake of primary percutaneous coronary intervention (59% vs 22%) and more frequent use of beta blockers at discharge (89% vs 78%). After casemix standardisation the 30-day mortality ratio for UK versus Sweden was 1.37 (95% CI 1.30-1.45), which corresponds to 11 263 (95% CI 9620-12 827) excess deaths, but did decline over time (from 1.47, 95% CI 1.38-1.58 in 2004 to 1.20, 1.12-1.29 in 2010; p=0.01). Interpretation We found clinically important differences between countries in acute myocardial infarction care and outcomes. International comparisons research might help to improve health systems and prevent deaths.
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| 33. |
- Comas, J, et al.
(author)
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Demonstration of a tool for automatic learning and reuse of knowledge in the activated sludge process
- 2006
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In: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 53:4-5, s. 303-311
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Journal article (peer-reviewed)abstract
- Wastewater treatment plant operators encounter complex operational problems related to the activated sludge process and usually respond to these by applying their own intuition and by taking advantage of what they have learnt from past experiences of similar problems. However, previous process experiences are not easy to integrate in numerical control, and new tools must be developed to enable re-use of plant operating experience. The aim of this paper is to investigate the usefulness of a case-based reasoning (CBR) approach to apply learning and re-use of knowledge gained during past incidents to confront actual complex problems through the IWA/COST Benchmark protocol. A case study shows that the proposed CBR system achieves a significant improvement of the benchmark plant performance when facing a high-flow event disturbance.
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| 34. |
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| 35. |
- Comas, J., et al.
(author)
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Risk assessment modelling of microbiology-related solids separation problems in activated sludge systems
- 2008
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In: Environmental Modelling & Software. - : Elsevier BV. - 1364-8152. ; 23:10-11, s. 1250-1261
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Journal article (peer-reviewed)abstract
- This paper proposes a risk assessment model for settling problems of microbiological origin in activated sludge systems (filamentous bulking, foaming and rising sludge). The aim of the model is not to diagnose microbiology-related solids separation problems with absolute certainty but to quantify in dynamic scenarios whether simulated operational procedures and control strategies lead to favourable conditions for them to arise or not. The rationale behind the model (which integrates the mechanisms of standard activated sludge models with empirical knowledge), its implementation in a fuzzy rule-based system and the details of its operation are illustrated in the different sections of the paper. The performance of the risk assessment model is illustrated by evaluating a number of control strategies facing different short-term influent conditions as well as long-term variability using the IWA/COST simulation benchmark. The results demonstrate that some control strategies, although performing better regarding operating costs and effluent quality, induce a higher risk for solids separation problems. In view of these results, it is suggested to integrate empirical knowledge into mechanistic models to increase reliability and to allow assessment of potential side-effects when simulating complex processes. (c) 2008 Elsevier Ltd. All rights reserved.
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| 36. |
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| 37. |
- Cramer, Bradley D., et al.
(author)
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Revised correlation of Silurian Provincial Series of North America with global and regional chronostratigraphic units and delta 13C(carb) chemostratigraphy
- 2011
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In: Lethaia. - : Scandinavian University Press / Universitetsforlaget AS. - 0024-1164. ; 44:2, s. 185-202
-
Research review (peer-reviewed)abstract
- Recent revisions to the biostratigraphic and chronostratigraphic assignment of strata from the type area of the Niagaran Provincial Series (a regional chronostratigraphic unit) have demonstrated the need to revise the chronostratigraphic correlation of the Silurian System of North America. Recently, the working group to restudy the base of the Wenlock Series has developed an extremely high-resolution global chronostratigraphy for the Telychian and Sheinwoodian stages by integrating graptolite and conodont biostratigraphy with carbonate carbon isotope (delta 13C(carb)) chemostratigraphy. This improved global chronostratigraphy has required such significant chronostratigraphic revisions to the North American succession that much of the Silurian System in North America is currently in a state of flux and needs further refinement. This report serves as an update of the progress on recalibrating the global chronostratigraphic correlation of North American Provincial Series and Stage boundaries in their type area. The revised North American classification is correlated with global series and stages as well as regional classifications used in the United Kingdom, the East Baltic, Australia, China, the Barrandian, and Altaj. Twenty-four potential stage slices, based primarily on graptolite and conodont zones and correlated to the global series and stages, are illustrated alongside a new composite delta 13C(carb) curve for the Silurian. Conodont, graptolite, isotope, New York, Ontario, series, Silurian, stage.
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| 38. |
- Cramer, Bradley D., et al.
(author)
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Testing the limits of Paleozoic chronostratigraphic correlation via high-resolution (<500 k.y.) integrated conodont, graptolite, and carbon isotope (delta C-13(carb)) biochemostratigraphy across the Llandovery-Wenlock (Silurian) boundary: Is a unified Phanerozoic time scale achievable?
- 2010
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In: Geological Society of America Bulletin. - 0016-7606. ; 122:9-10, s. 1700-1716
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Journal article (peer-reviewed)abstract
- The resolution and fidelity of global chronostratigraphic correlation are direct functions of the time period under consideration. By virtue of deep-ocean cores and astrochronology, the Cenozoic and Mesozoic time scales carry error bars of a few thousand years (k.y.) to a few hundred k. y. In contrast, most of the Paleozoic time scale carries error bars of plus or minus a few million years (m. y.), and chronostratigraphic control better than +/- 1 m. y. is considered "high resolution." The general lack of Paleozoic abyssal sediments and paucity of orbitally tuned Paleozoic data series combined with the relative incompleteness of the Paleozoic stratigraphic record have proven historically to be such an obstacle to intercontinental chronostratigraphic correlation that resolving the Paleozoic time scale to the level achieved during the Mesozoic and Cenozoic was viewed as impractical, impossible, or both. Here, we utilize integrated graptolite, conodont, and carbonate carbon isotope (delta C-13 carb) data from three paleocontinents (Baltica, Avalonia, and Laurentia) to demonstrate chronostratigraphic control for upper Llandovery through middle Wenlock (TelychianSheinwoodian, similar to 436-426 Ma) strata with a resolution of a few hundred k.y. The interval surrounding the base of the Wenlock Series can now be correlated globally with precision approaching 100 k.y., but some intervals (e. g., uppermost Telychian and upper Shein-woodian) are either yet to be studied in sufficient detail or do not show sufficient biologic speciation and/or extinction or carbon isotopic features to delineate such small time slices. Although producing such resolution during the Paleozoic presents an array of challenges unique to the era, we have begun to demonstrate that erecting a Paleozoic time scale comparable to that of younger eras is achievable.
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| 39. |
- Damman, Peter, et al.
(author)
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Invasive strategies and outcomes for non-ST-segment elevation acute coronary syndromes : a twelve-year experience from SWEDEHEART.
- 2016
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In: EuroIntervention. - 1774-024X .- 1969-6213. ; 12:9, s. 1108-1116
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Journal article (peer-reviewed)abstract
- AIMS: Despite recommendations in recent guidelines for a routine invasive strategy for non-ST-segment elevation acute coronary syndrome (NSTE-ACS), long-term data on the implementation of treatment strategies in clinical practice are not available. Our aim was to provide long-term data on the implementation of a routine invasive strategy in NSTE-ACS in clinical practice.METHODS AND RESULTS: In the SWEDEHEART registry, data from 204,092 consecutive NSTE-ACS patients admitted between 1996 and 2007 were recorded. The use of the routine invasive strategy, retrospectively defined as coronary angiography (and subsequent revascularisation) within three days after admission, increased from 3.8% in the period 1996-1998 to 37.4% in the period 2005-2007. The largest absolute increase in the use of this strategy was observed in low-risk patients, while a similar relative increase was observed in all risk categories. The use of the selective invasive strategy, defined as coronary angiography later than three days after admission or none at all, decreased from 96.2% in the period 1996-1998 to 62.5% in the period 2005-2007. In the total population, there was a gradual decrease in three-year all-cause mortality, from 29.1% in the period 1996-1998 to 23.9% in the period 2005-2007.CONCLUSIONS: There has been an increase in the use of a routine invasive strategy in NSTE-ACS patients over the course of 12 years in Sweden. There was a decrease in three-year mortality over the same time course.
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| 40. |
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| 41. |
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| 42. |
- Eketjäll, Susanna, et al.
(author)
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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics
- 2016
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 50:4, s. 1109-1123
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Journal article (peer-reviewed)abstract
- A growing body of pathological, biomarker, genetic, and mechanistic data suggests that amyloid accumulation, as a result of changes in production, processing, and/or clearance of brain amyloid-beta peptide (A beta) concentrations, plays a key role in the pathogenesis of Alzheimer's disease (AD). Beta-secretase 1 (BACE1) mediates the first step in the processing of amyloid-beta protein precursor (A beta PP) to A beta peptides, with the soluble N terminal fragment of A beta PP (sA beta PP beta) as a direct product, and BACE1 inhibition is an attractive target for therapeutic intervention to reduce the production of A beta. Here, we report the in vitro and in vivo pharmacological profile of AZD3293, a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. The in vitro potency of AZD3293 was demonstrated in several cellular models, including primary cortical neurons. In vivo in mice, guinea pigs, and dogs, AZD3293 displayed significant dose-and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of A beta(40), A beta(42), and sA beta PP beta. The in vitro potency of AZD3293 in mouse and guinea pig primary cortical neuronal cells was correlated to the in vivo potency expressed as free AZD3293 concentrations in mouse and guinea pig brains. In mice and dogs, the slow off-rate from BACE1 may have translated into a prolongation of the observed effect beyond the turnover rate of A beta. The preclinical data strongly support the clinical development of AZD3293, and patients with AD are currently being recruited into a combined Phase 2/3 study to test the disease-modifying properties of AZD3293.
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| 43. |
- Eriksson, Mats, et al.
(author)
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Vertebrate extinctions and reorganizations during the Late Silurian Lau Event
- 2009
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In: Geology. - 0091-7613. ; 37:8, s. 739-742
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Journal article (peer-reviewed)abstract
- During the Silurian Period, as shown here by data from Gotland, Sweden, and other regions of the Baltoscandian paleocontinent, fish faunas were struck hard by extinctions caused by the late Ludlow Lau Event, also known for being associated with the largest positive stable carbon isotope excursion of the Phanerozoic. This event had a profound impact on the early evolutionary history of vertebrates, wiping out two-thirds of the fish taxa and causing significant ecological reorganizations over an estimated time span of similar to 200 ka. Our data show that immediately prior to the event, jawed acanthodians dominated the fish faunas, whereas the event led to a diverse fauna and a brief but marked dominance of the jawless thelodonts. The stepwise changes observed mimic those of conodonts, suggesting a similar mode of life and response to atmospheric oceanic perturbations for these clades.
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| 49. |
- Flores, Xavier, et al.
(author)
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Towards a plant-wide Benchmark Simulation Model with simultaneous nitrogen and phosphorus removal wastewater treatment processes
- 2012
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Conference paper (peer-reviewed)abstract
- It is more than 10 years since the publication of the Benchmark Simulation Model No 1 (BSM1) manual (Copp, 2002). The main objective of BSM1 was creating a platform for benchmarking carbon and nitrogen removal strategies in activated sludge systems. The initial platform evolved into BSM1_LT and BSM2, which allowed the evaluation of monitoring and plant-wide control strategies, respectively. The fact that the BSM platforms have resulted in 300+ publications demonstrates the interest for the tool within the scientific community. In this paper, an extension of the BSM2 is proposed. This extension aims at facilitating simultaneous carbon, nitrogen and phosphorus (P) removal process development and performance evaluation at a plant-wide level. The main motivation of the work is that numerous wastewater treatment plants (WWTPs) pursue biological phosphorus removal as an alternative to chemical P removal based on precipitation using metal salts, such as Fe or Al. This paper identifies and discusses important issues that need to be addressed to upgrade the BSM2 to BSM2-P, for example: 1) new influent wastewater characteristics; 2) new (bio) chemical processes to account for; 3) modifications of the original BSM2 physical plant layout; 4) new/upgraded generic mathematical models; 5) model integration; 6) new control handles/sensors; and 7) new extended evaluation criteria. The paper covers and analyzes all these aspects in detail, identifying the main bottlenecks that need to be addressed and finally discusses the aspects where scientific consensus is required.
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