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1.
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2.
  • Klionsky, Daniel J., et al. (author)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Research review (peer-reviewed)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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3.
  • Beal, Jacob, et al. (author)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Journal article (peer-reviewed)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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4.
  • 2019
  • Journal article (peer-reviewed)
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5.
  • Akiyama, Kazunori, et al. (author)
  • The persistent shadow of the supermassive black hole of M 87: I. Observations, calibration, imaging, and analysis*
  • 2024
  • In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 681
  • Journal article (peer-reviewed)abstract
    • In April 2019, the Event Horizon Telescope (EHT) Collaboration reported the first-ever event-horizon-scale images of a black hole, resolving the central compact radio source in the giant elliptical galaxy M 87. These images reveal a ring with a southerly brightness distribution and a diameter of ∼42 μas, consistent with the predicted size and shape of a shadow produced by the gravitationally lensed emission around a supermassive black hole. These results were obtained as part of the April 2017 EHT observation campaign, using a global very long baseline interferometric radio array operating at a wavelength of 1.3 mm. Here, we present results based on the second EHT observing campaign, taking place in April 2018 with an improved array, wider frequency coverage, and increased bandwidth. In particular, the additional baselines provided by the Greenland telescope improved the coverage of the array. Multiyear EHT observations provide independent snapshots of the horizon-scale emission, allowing us to confirm the persistence, size, and shape of the black hole shadow, and constrain the intrinsic structural variability of the accretion flow. We have confirmed the presence of an asymmetric ring structure, brighter in the southwest, with a median diameter of 43.3-3.1+1.5 μas. The diameter of the 2018 ring is remarkably consistent with the diameter obtained from the previous 2017 observations. On the other hand, the position angle of the brightness asymmetry in 2018 is shifted by about 30 relative to 2017. The perennial persistence of the ring and its diameter robustly support the interpretation that the ring is formed by lensed emission surrounding a Kerr black hole with a mass ∼6.5× 109M. The significant change in the ring brightness asymmetry implies a spin axis that is more consistent with the position angle of the large-scale jet.
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6.
  • Chen, Zhi, et al. (author)
  • Large-Area Crystalline Zeolitic Imidazolate Framework Thin Films
  • 2021
  • In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:25, s. 14124-14130
  • Journal article (peer-reviewed)abstract
    • We report that continuous MOF films with highly controlled thickness (from 44 to 5100 nm) can be deposited over length scales greater than 80 centimeters by a facile, fast, and cost-effective spray-coating method. Such success relies on our discovery of unprecedented perfectly dispersed colloidal solutions consisting of amorphous MOF nanoparticles, which we adopted as precursors that readily converted to the crystalline films upon low-temperature in situ heating. The colloidal solutions allow for the fabrication of compact and uniform MOF films on a great deal of substrates such as fluorine-doped tin oxide, glass, SiO2, Al2O3, Si, Cu, and even flexible polycarbonate, widening their technological applications where substrates are essential. Despite the present work focuses on the fabrication of uniform cobalt-(2-methylimidazole)2 and zinc-(2-methylimidazole)2 films, our findings mark a great possibility in producing other high-quality MOF thin films on a large scale.
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7.
  • Gao, Zhi xin, et al. (author)
  • Progress of passive enhanced heat transfer tubes
  • 2017
  • In: Xiandai Huagong/Modern Chemical Industry. - 0253-4320. ; 37:3, s. 24-30
  • Research review (peer-reviewed)abstract
    • A review of several typical enhanced heat transfer tubes such as corrugated tube, transversally corrugated tube, twisted tube and spiral fluted tube, is carried out. Compared with smooth wall tube, these enhanced tubes have higher heat exchange capacity and better anti - fouling ability. Besides, the heat transfer efficiency can be promoted to a higher level if the objects that can disturb flow are put in the tubes. However, higher heat transfer efficiency of such enhanced heat transfer tubes can only be achieved under certain conditions. Therefore, new heat transfer tubes that could avoid the formation of mobile dead-zone should be designed to meet the broad applications or facilitate better heat transfer effect.
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8.
  • Hou, Cong wei, et al. (author)
  • Parametric analysis on throttling components of multi-stage high pressure reducing valve
  • 2018
  • In: Applied Thermal Engineering. - : Elsevier BV. - 1359-4311. ; 128, s. 1238-1248
  • Journal article (peer-reviewed)abstract
    • High pressure reducing valve (HPRV) is widely used for pressure and temperature control of heated steams in power plant and other related process engineering. The structures of throttling components inside HPRVs have important effects on the control performances. In this paper, a parametric study of throttling components in a multi-stage high pressure reducing valve (MSHPRV) is carried out, including the relative angle of inner and outer porous shrouded holes, the orifice plate thickness, the number of orifice plates and the diameter of plate holes. A numerical model is established to investigate internal flow and throttling characteristics with RNG k-ε model, and it is validated by the theoretical flux calculation. The results show that, the relative angle set as 180° can obtain the largest decompression pressure when steam flows through porous shrouded valve core, while the turbulence degree is the lowest. Setting one orifice plate can decrease the turbulent dissipation rate. The plate thickness has less influence on throttling effects. For ensuring the outlet flux, plate holes with smaller diameters should be chosen with a better flowing property on thermodynamic parameters. The work can be referred by the design work of throttling components in MSHPRV and it can also benefit the further research on similar HPRVs.
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9.
  • Jiang, Bin, et al. (author)
  • Experimental observation of non-Abelian topological acoustic semimetals and their phase transitions
  • 2021
  • In: Nature Physics. - : Springer Science and Business Media LLC. - 1745-2473 .- 1745-2481. ; 17, s. 1239-1246
  • Journal article (peer-reviewed)abstract
    • Topological phases of matter connect mathematical principles to real materials, and may shape future electronic and quantum technologies. So far, this discipline has mostly focused on single-gap topology described by topological invariants such as Chern numbers. Here, based on a tunable kagome model, we observe non-Abelian band topology and its transitions in acoustic semimetals, in which the multi-gap Hilbert space plays a key role. In non-Abelian semimetals, the topological charges of band nodes are converted through the braiding of nodes in adjacent gaps, and their behaviour cannot be captured by conventional topological band theory. Using kagome acoustic metamaterials and pump–probe measurements, we demonstrate the emergence of non-Abelian topological nodes, identify their dispersions and observe the induced multi-gap topological edge states. By controlling the geometry of the metamaterials, topological transitions are induced by the creation, annihilation, merging and splitting of band nodes. This reveals the underlying rules for the conversion and transfer of non-Abelian topological charges in multiple bandgaps. The resulting laws that govern the evolution of band nodes in non-Abelian multi-gap systems should inspire studies on multi-band topological semimetals and multi-gap topological out-of-equilibrium systems.
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10.
  • Jiang, Bin, et al. (author)
  • Observation of an acoustic topological Euler insulator with meronic waves
  • 2024
  • In: Science Bulletin. - : Elsevier BV. - 2095-9273. ; 69:11, s. 1653-1659
  • Journal article (peer-reviewed)abstract
    • Topological band theory has conventionally been concerned with the topology of bands around a single gap. Only recently non-Abelian topologies that thrive on involving multiple gaps were studied, unveiling a new horizon in topological physics beyond the conventional paradigm. Here, we report on the first experimental realization of a topological Euler insulator phase with unique meronic characterization in an acoustic metamaterial. We demonstrate that this topological phase has several nontrivial features: First, the system cannot be described by conventional topological band theory, but has a nontrivial Euler class that captures the unconventional geometry of the Bloch bands in the Brillouin zone. Second, we uncover in theory and probe in experiments a meronic configuration of the bulk Bloch states for the first time. Third, using a detailed symmetry analysis, we show that the topological Euler insulator evolves from a non-Abelian topological semimetal phase via. the annihilation of Dirac points in pairs in one of the band gaps. With these nontrivial properties, we establish concretely an unconventional bulk-edge correspondence which is confirmed by directly measuring the edge states via. pump-probe techniques. Our work thus unveils a nontrivial topological Euler insulator phase with a unique meronic pattern and paves the way as a platform for non-Abelian topological phenomena.
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11.
  • Jin, Zhi-jiang, et al. (author)
  • A parametric study of hydrodynamic cavitation inside globe valves
  • 2018
  • In: Journal of Fluids Engineering. - : ASME International. - 0098-2202 .- 1528-901X. ; 140:3
  • Journal article (peer-reviewed)abstract
    • Hydrodynamic cavitation that occurs inside valves not only increases the energy consumption burden of the whole piping system but also leads to severe damages to the valve body and the piping system with a large economic loss. In this paper, in order to reduce the hydrodynamic cavitation inside globe valves, effects of valve body geometrical parameters including bending radius, deviation distance, and arc curvature linked to in/ export parts on hydrodynamic cavitation are investigated by using a cavitation model. To begin with, the numerical model is compared with similar works to check its accuracy. Then, the cavitation index and the total vapor volume are predicted. The results show that vapor primarily appears around the valve seat and connecting downstream pipes. The hydrodynamic cavitation does not occur under a small inlet velocity, a large bending radius, and a large deviation distance. Cavitation intensity decreases with the increase of the bending radius, the deviation distance, and the arc curvature linked to in/export parts. This indicates that valve geometrical parameters should be chosen as large as possible, while the maximal fluid velocity should be limited. This work is of significance for hydrodynamic cavitation or globe valve design.
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12.
  • Jin, Zhi Jiang, et al. (author)
  • Cavitating flow through a micro-orifice
  • 2019
  • In: Micromachines. - : MDPI AG. - 2072-666X. ; 10:3
  • Journal article (peer-reviewed)abstract
    • Microfluidic systems have witnessed rapid development in recent years. As one of the most common structures, the micro-orifice is always included inside microfluidic systems. Hydrodynamic cavitation in the micro-orifice has been experimentally discovered and is harmful to microfluidic systems. This paper investigates cavitating flow through a micro-orifice. A rectangular micro-orifice with a l/d ratio varying from 0.25 to 4 was selected and the pressure difference between the inlet and outlet varied from 50 to 300 kPa. Results show that cavitation intensity increased with an increase in pressure difference. Decreasing exit pressure led to a decrease in cavitation number and cavitation could be prevented by increasing the exit pressure. In addition, the vapor cavity also increased with an increase in pressure difference and l/d ratio. Results also show the pressure ratio at cavitation inception was 1.8 when l/d was above 0.5 and the cavitation number almost remained constant when l/d was larger than 2. Moreover, there was an apparent difference in cavitation number depending on whether l/d was larger than 1.
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13.
  • Jin, Zhi Jiang, et al. (author)
  • Computational fluid dynamics analysis on orifice structure inside valve core of pilot-control angle globe valve
  • 2018
  • In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science. - : SAGE Publications. - 0954-4062 .- 2041-2983. ; 232:13, s. 2419-2429
  • Journal article (peer-reviewed)abstract
    • A novel pilot-control angle globe valve is proposed, and it has an obvious advantage of energy conservation during its opening and closing process. In pilot-control angle globe valve, the opening and closing forces are related to the orifice located inside the valve core. In this paper, the effects of orifice diameter are thoroughly studied under different working conditions such as valve core displacements and inlet velocities. To begin with, the numerical model is validated by comparing similar angle valves, and then the flow and loss coefficients under different orifice diameters are discussed. It is found that the effects of orifice diameter on force acting on valve core depend on valve core displacement and inlet velocity. Thus different valve core displacements and inlet velocities combined with different orifice diameters are further studied. It is also found that when the orifice diameter is larger than 12 mm, pilot-control angle globe valve cannot be used under small inlet velocity or large valve core displacement. In addition, formulas to calculate forces on valve core are proposed for further orifice design. This work can be referred in process industries especially in a piping system with orifice plates or globe valves.
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14.
  • Jin, Zhi jiang, et al. (author)
  • Effects of pitch and corrugation depth on heat transfer characteristics in six-start spirally corrugated tube
  • 2017
  • In: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310. ; 108, s. 1011-1025
  • Journal article (peer-reviewed)abstract
    • Spirally corrugated tube is one of the most important parts of coaxial heat exchangers. It can greatly improve the heat transfer efficiency of heat exchangers. Here, a novel spirally corrugated tube with six-start is proposed. However, up to now, there is little literature about the heat transfer performance and flow field of this novel six-start spirally corrugated tube. In this paper, the effects of geometric parameters (pitch p, corrugation depth e), Reynolds number Re and fluid properties on the heat transfer performances are investigated based on the validated numerical model. The results show that with the increasing of pitch p, both the heat transfer coefficient h and Nusselt number Nu decrease gradually. Meanwhile, with the increasing of corrugation depth e, both the secondary flow velocity vxy and the vorticity of longitudinal vortex increase gradually. Moreover, under the same working condition, the heat transfer performances of the six-start spirally corrugated tube are affected by both the working medium and Reynolds number. Finally, a criterion correlation for heat transfer calculation in the six-start spirally corrugated tube is proposed and validated to be reliable and suitable. This work can reveal the enhanced heat transfer mechanism of the six-start spirally corrugated tube and benefit the further research on heat transfer characteristics of multi-start spirally corrugated tube or other related devices.
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15.
  • Jin, Zhi-jiang, et al. (author)
  • Pressure Drop Analysis of Pilot-Control Globe Valve With Different Structural Parameters
  • 2017
  • In: Journal of Fluids Engineering. - : ASME International. - 0098-2202 .- 1528-901X. ; 139:9
  • Journal article (peer-reviewed)abstract
    • Pilot-control globe valve (PCGV) can use the pressure drop caused by fluid flowing through the orifice located at valve core bottom to open or close the main valve using a small pilot valve. In this paper, computational fluid dynamics (CFD) method is adopted to analyze the pressure drop before and after valve core of PCGV and minor loss of orifice under different structural parameters and inlet velocities, and the simulation results show a good agreement with the experimental results. It turns out that the valve diameters, orifice diameters, and pilot pipe diameters have great influences on the pressure drop and the loss coefficient. Moreover, an expression is proposed which can be used to calculate minor loss coefficient, then to estimate the pressure drop and driving force of a PCGV within limited conditions. This paper can be referenced as guidance for deciding the dimension of structural parameters and spring stiffness during design process of a PCGV.
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16.
  • Kim, Jae-Young, et al. (author)
  • Event Horizon Telescope imaging of the archetypal blazar 3C 279 at an extreme 20 microarcsecond resolution
  • 2020
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 640
  • Journal article (peer-reviewed)abstract
    • 3C 279 is an archetypal blazar with a prominent radio jet that show broadband flux density variability across the entire electromagnetic spectrum. We use an ultra-high angular resolution technique - global Very Long Baseline Interferometry (VLBI) at 1.3mm (230 GHz) - to resolve the innermost jet of 3C 279 in order to study its fine-scale morphology close to the jet base where highly variable-ray emission is thought to originate, according to various models. The source was observed during four days in April 2017 with the Event Horizon Telescope at 230 GHz, including the phased Atacama Large Millimeter/submillimeter Array, at an angular resolution of ∼20 μas (at a redshift of z = 0:536 this corresponds to ∼0:13 pc ∼ 1700 Schwarzschild radii with a black hole mass MBH = 8 × 108 M⊙). Imaging and model-fitting techniques were applied to the data to parameterize the fine-scale source structure and its variation.We find a multicomponent inner jet morphology with the northernmost component elongated perpendicular to the direction of the jet, as imaged at longer wavelengths. The elongated nuclear structure is consistent on all four observing days and across diffierent imaging methods and model-fitting techniques, and therefore appears robust. Owing to its compactness and brightness, we associate the northern nuclear structure as the VLBI "core". This morphology can be interpreted as either a broad resolved jet base or a spatially bent jet.We also find significant day-to-day variations in the closure phases, which appear most pronounced on the triangles with the longest baselines. Our analysis shows that this variation is related to a systematic change of the source structure. Two inner jet components move non-radially at apparent speeds of ∼15 c and ∼20 c (∼1:3 and ∼1:7 μas day-1, respectively), which more strongly supports the scenario of traveling shocks or instabilities in a bent, possibly rotating jet. The observed apparent speeds are also coincident with the 3C 279 large-scale jet kinematics observed at longer (cm) wavelengths, suggesting no significant jet acceleration between the 1.3mm core and the outer jet. The intrinsic brightness temperature of the jet components are ≤1010 K, a magnitude or more lower than typical values seen at ≥7mm wavelengths. The low brightness temperature and morphological complexity suggest that the core region of 3C 279 becomes optically thin at short (mm) wavelengths.
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17.
  • Lu, R.S., et al. (author)
  • A ring-like accretion structure in M87 connecting its black hole and jet
  • 2023
  • In: Nature. - 0028-0836 .- 1476-4687. ; 616:7958, s. 686-690
  • Journal article (peer-reviewed)abstract
    • The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole3. Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of [Formula: see text] Schwarzschild radii in diameter, approximately 50% larger than that seen at 1.3 mm. The outer edge at 3.5 mm is also larger than that at 1.3 mm. This larger and thicker ring indicates a substantial contribution from the accretion flow with absorption effects, in addition to the gravitationally lensed ring-like emission. The images show that the edge-brightened jet connects to the accretion flow of the black hole. Close to the black hole, the emission profile of the jet-launching region is wider than the expected profile of a black-hole-driven jet, suggesting the possible presence of a wind associated with the accretion flow.
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18.
  • Pecunia, Vincenzo, et al. (author)
  • Roadmap on energy harvesting materials
  • 2023
  • In: Journal of Physics. - : IOP Publishing. - 2515-7639. ; 6:4
  • Journal article (peer-reviewed)abstract
    • Ambient energy harvesting has great potential to contribute to sustainable development and address growing environmental challenges. Converting waste energy from energy-intensive processes and systems (e.g. combustion engines and furnaces) is crucial to reducing their environmental impact and achieving net-zero emissions. Compact energy harvesters will also be key to powering the exponentially growing smart devices ecosystem that is part of the Internet of Things, thus enabling futuristic applications that can improve our quality of life (e.g. smart homes, smart cities, smart manufacturing, and smart healthcare). To achieve these goals, innovative materials are needed to efficiently convert ambient energy into electricity through various physical mechanisms, such as the photovoltaic effect, thermoelectricity, piezoelectricity, triboelectricity, and radiofrequency wireless power transfer. By bringing together the perspectives of experts in various types of energy harvesting materials, this Roadmap provides extensive insights into recent advances and present challenges in the field. Additionally, the Roadmap analyses the key performance metrics of these technologies in relation to their ultimate energy conversion limits. Building on these insights, the Roadmap outlines promising directions for future research to fully harness the potential of energy harvesting materials for green energy anytime, anywhere.
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19.
  • Qian, Jin Yuan, et al. (author)
  • Effects of dimple cone angles on heat transfer and pressure drop in a dimple jacketed heat exchanger
  • 2017
  • In: Proceedings of CHT-17 ICHMT International Symposium on Advances in Computational Heat Transfer, 2017. - 9781567004618 ; , s. 2013-2020
  • Conference paper (peer-reviewed)abstract
    • A Dimple Jacket Heat Exchanger (DJHE) is designed for the Chemical Post-Processing Integrated Equipment (CPPIE) to enhance the heat transfer performance during chemical reaction, crystallization and drying processes. In this paper, a 3D model of a DJHE is established. Dynamic variation of temperature inside the DJHE is compared with experimental data to validate the accuracy of the numerical method. Then, by choosing one dimple from the whole DJHE as the research object, the effects of different dimple cone angles on heat transfer and pressure drop characteristics are analyzed with the validated method. The results show that the dimple cone angle has an obvious effect on the heat transfer and pressure drop performance. This work can reduce the uncertain design of DJHE, and it can also be referred by similar research works on dimple surfaces.
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20.
  • Qian, Jin Yuan, et al. (author)
  • Experimental and numerical analysis of spring stiffness on flow and valve core movement in pilot control globe valve
  • 2017
  • In: International Journal of Hydrogen Energy. - : Elsevier BV. - 0360-3199. ; 42:27, s. 17192-17201
  • Journal article (peer-reviewed)abstract
    • Valves are widely used for fluid flow control, not only for conventional fluid like water, gas and oil, but also for hydrogen under high pressure and so forth. Under these new conditions, the response time and energy consumption of valves are closely related to the whole performance of the piping system. Pilot-control globe valve (PCGV) is a novel quick response valve, which can utilize the pressure difference before and after the valve core to control the open/close states of the main valve. In this paper, the effects of spring stiffness inside PCGV on the flow and the valve core movement are carried out, respectively. To begin with, the experimental setup is introduces and the 3D numerical model is established. The simulation is carried out in software FLUENT with RNG k-ε turbulence model, User Defined Function method and dynamic mesh regeneration methods under transmit state. Then, a comparison of steady valve core displacements between experiment and simulation is carried out. After that, the effects of spring stiffness on flow characteristics, valve core movement and response times during opening and closing periods are presented. Finally, a spring chosen correction equation is proposed. This work can benefit the further design work of PCGVs or similar valves with springs, and it can be also referred by someone dealing with novel control valves design or flow control issues.
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21.
  • Qian, Jin yuan, et al. (author)
  • Flow rate analysis of compressible superheated steam through pressure reducing valves
  • 2017
  • In: Energy. - : Elsevier BV. - 0360-5442. ; 135, s. 650-658
  • Journal article (peer-reviewed)abstract
    • Steam flow is the main form for energy transfer in power plants, process industries, etc. The flow rate of the steam relates to the energy transfer amount directly. Pressure reducing valves are used for flow rate control of the compressible superheated steam in these piping systems. In this paper, a pressure reducing valve with a novel valve core is proposed. In order to analyze the internal flow characteristics of the compressible superheated steam and the flow rate adjustment performance of the proposed pressure reducing valve, a numerical model of DN80 pressure reducing valve is established. Then, the flow characteristics inside are studied numerically. Meanwhile, the flow rate adjustment performance is also carried out experimentally. Compared with the numerical and experimental results, it shows an agreement and both of them are similar to linear flow rate. Furthermore, a fitting equation for the flow rate prediction is carried out for the engineering applications under different working conditions.
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22.
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23.
  • Zhang, Zhi-Yong, et al. (author)
  • Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum
  • 2007
  • In: Tumor Biology. - : Springer Science and Business Media LLC. - 1010-4283 .- 1423-0380. ; 28:2, s. 93-99
  • Journal article (peer-reviewed)abstract
    • Objectives: It was the aim of this study to investigate Nup88 expression in normal colorectal mucosa, adenoma, adenocarcinoma and lymph node metastasis, as well as the relationship between Nup88 expression and clinicopathological features. Methods: Nup88 expression was examined by immunohistochemistry in 84 normal mucosa samples, 32 adenomas, 181 primary adenocarcinomas, and 18 lymph node metastases from colorectal tumour patients. Results: Nup88 expression was observed in normal epithelial and tumour cells. The frequency of strong Nup88 expression was increased from normal mucosa or adenoma to primary tumour and lymph node metastasis (p < 0.0001). There was no significant difference in the expression between normal mucosa and adenoma (p = 0.41). The frequency of strong Nup88 expression was higher in ulcerated tumours (40%) than in polypoid/large fungating tumours (23%, p = 0.048). The frequency of strong Nup88 expression was significantly different among tumours with good (21%), moderate (42%) and poor differentiation (48%, p = 0.01). Nup88 expression was not related to the patients' gender, age, tumour location, size, histological type, invasive depth, lymph node status and Dukes stage (p > 0.05). Conclusion: Our results suggest that Nup88 may play a role during the development, aggressiveness and differentiation of colorectal tumours. Copyright © 2007 S. Karger AG.
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24.
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25.
  • Akiyama, Kazunori, et al. (author)
  • First M87 Event Horizon Telescope Results. IX. Detection of Near-horizon Circular Polarization
  • 2023
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 957:2
  • Journal article (peer-reviewed)abstract
    • Event Horizon Telescope (EHT) observations have revealed a bright ring of emission around the supermassive black hole at the center of the M87 galaxy. EHT images in linear polarization have further identified a coherent spiral pattern around the black hole, produced from ordered magnetic fields threading the emitting plasma. Here we present the first analysis of circular polarization using EHT data, acquired in 2017, which can potentially provide additional insights into the magnetic fields and plasma composition near the black hole. Interferometric closure quantities provide convincing evidence for the presence of circularly polarized emission on event-horizon scales. We produce images of the circular polarization using both traditional and newly developed methods. All methods find a moderate level of resolved circular polarization across the image (〈|v|〉 < 3.7%), consistent with the low image-integrated circular polarization fraction measured by the Atacama Large Millimeter/submillimeter Array (|vint| < 1%). Despite this broad agreement, the methods show substantial variation in the morphology of the circularly polarized emission, indicating that our conclusions are strongly dependent on the imaging assumptions because of the limited baseline coverage, uncertain telescope gain calibration, and weakly polarized signal. We include this upper limit in an updated comparison to general relativistic magnetohydrodynamic simulation models. This analysis reinforces the previously reported preference for magnetically arrested accretion flow models. We find that most simulations naturally produce a low level of circular polarization consistent with our upper limit and that Faraday conversion is likely the dominant production mechanism for circular polarization at 230 GHz in M87*
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26.
  • Akiyama, Kazunori, et al. (author)
  • First Sagittarius A∗ Event Horizon Telescope Results. VII. Polarization of the Ring
  • 2024
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 964:2
  • Journal article (peer-reviewed)abstract
    • The Event Horizon Telescope observed the horizon-scale synchrotron emission region around the Galactic center supermassive black hole, Sagittarius A∗ (Sgr A∗), in 2017. These observations revealed a bright, thick ring morphology with a diameter of 51.8 ± 2.3 μas and modest azimuthal brightness asymmetry, consistent with the expected appearance of a black hole with mass M≈ 4 × 106 M⊙. From these observations, we present the first resolved linear and circular polarimetric images of Sgr A∗. The linear polarization images demonstrate that the emission ring is highly polarized, exhibiting a prominent spiral electric vector polarization angle pattern with a peak fractional polarization of ∼40% in the western portion of the ring. The circular polarization images feature a modestly (∼5%°-10%) polarized dipole structure along the emission ring, with negative circular polarization in the western region and positive circular polarization in the eastern region, although our methods exhibit stronger disagreement than for linear polarization. We analyze the data using multiple independent imaging and modeling methods, each of which is validated using a standardized suite of synthetic data sets. While the detailed spatial distribution of the linear polarization along the ring remains uncertain owing to the intrinsic variability of the source, the spiraling polarization structure is robust to methodological choices. The degree and orientation of the linear polarization provide stringent constraints for the black hole and its surrounding magnetic fields, which we discuss in an accompanying publication.
  •  
27.
  • Akiyama, Kazunori, et al. (author)
  • First Sagittarius A∗ Event Horizon Telescope Results. VIII. Physical Interpretation of the Polarized Ring
  • 2024
  • In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 964:2
  • Journal article (peer-reviewed)abstract
    • In a companion paper, we present the first spatially resolved polarized image of Sagittarius A∗ on event horizon scales, captured using the Event Horizon Telescope, a global very long baseline interferometric array operating at a wavelength of 1.3 mm. Here we interpret this image using both simple analytic models and numerical general relativistic magnetohydrodynamic (GRMHD) simulations. The large spatially resolved linear polarization fraction (24%-28%, peaking at ∼40%) is the most stringent constraint on parameter space, disfavoring models that are too Faraday depolarized. Similar to our studies of M87∗, polarimetric constraints reinforce a preference for GRMHD models with dynamically important magnetic fields. Although the spiral morphology of the polarization pattern is known to constrain the spin and inclination angle, the time-variable rotation measure (RM) of Sgr A∗ (equivalent to ≈ 46° ± 12° rotation at 228 GHz) limits its present utility as a constraint. If we attribute the RM to internal Faraday rotation, then the motion of accreting material is inferred to be counterclockwise, contrary to inferences based on historical polarized flares, and no model satisfies all polarimetric and total intensity constraints. On the other hand, if we attribute the mean RM to an external Faraday screen, then the motion of accreting material is inferred to be clockwise, and one model passes all applied total intensity and polarimetric constraints: a model with strong magnetic fields, a spin parameter of 0.94, and an inclination of 150°. We discuss how future 345 GHz and dynamical imaging will mitigate our present uncertainties and provide additional constraints on the black hole and its accretion flow.
  •  
28.
  • Algaba, Juan-Carlos, et al. (author)
  • Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
  • 2021
  • In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
  • Research review (peer-reviewed)abstract
    • In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
  •  
29.
  • Broderick, Avery E., et al. (author)
  • THEMIS: A Parameter Estimation Framework for the Event Horizon Telescope
  • 2020
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 897:2
  • Journal article (peer-reviewed)abstract
    • The Event Horizon Telescope (EHT) provides the unprecedented ability to directly resolve the structure and dynamics of black hole emission regions on scales smaller than their horizons. This has the potential to critically probe the mechanisms by which black holes accrete and launch outflows, and the structure of supermassive black hole spacetimes. However, accessing this information is a formidable analysis challenge for two reasons. First, the EHT natively produces a variety of data types that encode information about the image structure in nontrivial ways; these are subject to a variety of systematic effects associated with very long baseline interferometry and are supplemented by a wide variety of auxiliary data on the primary EHT targets from decades of other observations. Second, models of the emission regions and their interaction with the black hole are complex, highly uncertain, and computationally expensive to construct. As a result, the scientific utilization of EHT observations requires a flexible, extensible, and powerful analysis framework. We present such a framework, Themis, which defines a set of interfaces between models, data, and sampling algorithms that facilitates future development. We describe the design and currently existing components of Themis, how Themis has been validated thus far, and present additional analyses made possible by Themis that illustrate its capabilities. Importantly, we demonstrate that Themis is able to reproduce prior EHT analyses, extend these, and do so in a computationally efficient manner that can efficiently exploit modern high-performance computing facilities. Themis has already been used extensively in the scientific analysis and interpretation of the first EHT observations of M87.
  •  
30.
  • Chen, Fu Qiang, et al. (author)
  • CFD analysis on flow characteristics of perforated plate in multi-stage high pressure reducing valve
  • 2018
  • In: Proceedings of the 3rd Thermal and Fluid Engineering Summer Conference, TFESC 2018. - 2379-1748. - 9781567004724 ; 2018-March, s. 339-351
  • Conference paper (peer-reviewed)abstract
    • Perforated plate is taken as an important throttling component to regulate pressure in a pressure reducing valve or a high pressure vessel etc., based on its special structural characteristics. To regulate pressure to a target value, a self-designed multi-stage high pressure reducing valve (MSHPRV) is proposed. It has such advantages as avoiding noise and vibration. In this paper, flow fields analysis on perforated plate in MSHPRV is conducted from three aspects based on a validated numerical model. Firstly, different stages of perforated plate are investigated to figure out the impact of stage on flow fields. Secondly, different apertures of perforated plate are studied to find its impact on flow fields. Finally, different pressure ratios are discussed, in that pressure ratio plays an important role in flow field distribution. This work can benefit the further research work on perforated plate flow investigation and multi-stage design of pressure reducing devices and so forth.
  •  
31.
  • Chen, Fu qiang, et al. (author)
  • Pressure analysis on two-step high pressure reducing system for hydrogen fuel cell electric vehicle
  • 2017
  • In: International Journal of Hydrogen Energy. - : Elsevier BV. - 0360-3199. ; 42:16, s. 11541-11552
  • Journal article (peer-reviewed)abstract
    • Hydrogen fuel cell electric vehicle (FCEV) can achieve zero exhaust emission and zero pollution. In order to make FCEV reach a farther travel distance, greater demands are put on its pressure reducing system. In this paper, a two-step high pressure reducing system for FCEV is proposed. The system is made up of two parts, a new high multi-stage pressure reducing valve (HMSPRV) and a multi-stage muffler. As a new system, its feasibility has to be verified. Since the valve opening condition has a great effect on hydrogen flow, pressure reduction and energy consumption, different valve opening conditions are taken as the research point. The flow field analysis of the new HMSPRV is conducted on three aspects: pressure field, velocity field and energy consumption. It can be found that both the pressure reducing and velocity increasing gradients mainly reflect at those throttling components for all valve openings. For energy consumption, in the comprehensive study of flow vortexes and turbulent dissipation rate, it can be found that the larger of the valve opening, the larger of energy consumption. Then, a thermo-fluid-solid coupling analysis is conducted on the new HMSPRV, and it is concluded that the new system meets strength requirement. Furthermore, as the second step of the high pressure reducing system, the flow and pressure fields of multi-stage muffler are investigated. The five-stage muffler is exactly designed to complete the whole pressure reducing process. This study can provide technological support for achieving pressure regulation in the hydrogen transport system of FCEV when facing complex conditions, and it can also benefit the further research work on energy saving and multi-stage flow of pressure reducing devices.
  •  
32.
  • Chen, Fu qiang, et al. (author)
  • Thermo-mechanical stress and fatigue damage analysis on multi-stage high pressure reducing valve
  • 2017
  • In: Annals of Nuclear Energy. - : Elsevier BV. - 0306-4549. ; 110, s. 753-767
  • Journal article (peer-reviewed)abstract
    • A multi-stage high pressure reducing valve (MSHPRV) is proposed. It can achieve a multi-stage pressure reducing way. Valve failure mainly occurs under high pressure and high temperature conditions, thus it is necessary to investigate the strength of MSHPRV under those complex conditions. In this paper, the mathematical model of MSHPRV is established and Computational Fluid Dynamics (CFD) method is employed to simulate its flow fields and thermo-mechanical stress. Next, the stress of MSHPRV under different opening time and the fatigue damage of MSHPRV under different valve openings are studied. Finally, two changes are provided on geometry of MSHPRV and the geometrical factors are optimized. The results show that, the radial direction from inner wall to outer wall is the main heat transfer direction for valve body. At opening time 50 s, the working condition of MSHPRV is dangerous condition. Meanwhile, the maximum value of thermal stress is 487 MPa, which is located at the upper end face of valve chamber region B3. There is a lag effect of stress distribution with respect to temperature distribution. The combined stress of valve body is composed of thermal stress and mechanical stress, in which thermal stress holds the dominant position. Moreover, with the increasing of valve opening, the fatigue damage of valve body increases correspondingly. It can be concluded that MSHPRV can cope with complex conditions like high pressure and high temperature. In the optimization design of MSHPRV, it can be found that the best strength of MSHPRV is achieved with such geometrical factors as angle 15, diameter 4 mm and 2 stage plates. Besides, radian design as the improved structure is recommended. This work can benefit the further research work on the regulation performance and safe operation of high pressure reducing valve.
  •  
33.
  • Chen, Fu qiang, et al. (author)
  • Turbulent compressible flow analysis on multi-stage high pressure reducing valve
  • 2018
  • In: Flow Measurement and Instrumentation. - : Elsevier BV. - 0955-5986. ; 61, s. 26-37
  • Journal article (peer-reviewed)abstract
    • Pressure reducing valve plays an important role in thermodynamic systems. Under extreme operating conditions, greater demands are requested on pressure reducing systems. In this paper, a novel multi-stage high pressure reducing valve (MSHPRV) is proposed, which can achieve multi-stage pressure reducing processes, improve the flow characteristics and deal with complex conditions. Here, the effects of different structural parameters on turbulent compressible flow inside MSHPRV are numerically investigated to achieve low valve noise and energy consumption. Mach number is taken as the parameter to reflect the fluid compressibility. Higher Mach number can cause serious aerodynamic noise and large amount of energy consumption. Based on this, transmission loss of MSHPRV is also studied to achieve better noise control performances. Meanwhile, larger turbulent dissipation rate means larger degree of energy consumption, so it is with the exergy loss. Thus, numerical models with different valve openings, perforated plate diameters, chamfer radii of perforated plates, pressure ratios and stages of perforated plates are established, and the effects of these structural parameters on the compressible turbulent flow and energy consumption of MSHPRV are investigated. Results show that different structural parameters have significant impacts on compressible turbulent flow and energy consumption performance in MSHPRV. The best noise control and least energy consumption of MSHPRV is achieved with such parameters as pressure ratio 7, perforated plate diameter 4 mm and 4 stage plates. This work can benefit the further research work on energy saving and multi-stage design of pressure reducing devices.
  •  
34.
  • Chen, Min Rui, et al. (author)
  • Effects of nanoparticles on hydraulic cavitation
  • 2018
  • In: XI International Conference on Computational Heat, Mass and Momentum Transfer (ICCHMT 2018). - : EDP Sciences. ; 240
  • Conference paper (peer-reviewed)abstract
    • When liquids flowing through a throttling element, such as a perforated plate, the velocity increases and the pressure decreases. If the pressure is below the saturated vapor pressure, the liquid will vaporize into small bubbles, which is called hydraulic cavitation. In fact, vaporization nucleus is another crucial condition for vaporizing. The nanoparticles contained in the nanofluids play a significant role in vaporization of liquids. In this paper, the effects of the nanoparticles on hydraulic cavitation are investigated. Firstly, a geometric model of a pipe channel equipped with a perforated plate is established. Then with different nanoparticle volume fractions and diameters, the nanofluids flowing through the channel is numerically simulated based on a validated numerical method. The operation conditions, such as the temperature and the pressure ratio of inlet to outlet, are the considered variables. As a significant parameter, cavitation numbers under different operation conditions are achieved to investigate the effects of nanoparticles on hydraulic cavitation. Meanwhile, the contours are extracted to research the distribution of bubbles for further investigation. This study is of interests for researchers working on hydraulic cavitation or nanofluids.
  •  
35.
  • Chen, Min Rui, et al. (author)
  • Numerical Simulation of Droplet Generation in Cross-Junction Microchannel under Changing Dispersion Phase Velocities
  • 2018
  • In: Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities. - 1003-9015. ; 32:3, s. 522-528
  • Journal article (peer-reviewed)abstract
    • Micro-droplets with excellent physical properties and size effects are widely used in different fields. Peristaltic pumps are often used for droplet generation. The thrust force of pumps is periodic as a periodic disturbance when the time scale is short enough. Numerical simulation based on a validated model was applied to study the periodic disturbance effects on droplet generation in a cross-junction microchannel. A volume of fluid (VOF) method was adopted with the continuous phase of silicon oil and the disperse phase of water. When the velocity of the continuous and dispersed phases is both 0.01 m∙s-1, the droplet generation time is 0.08 s. Sine functions with cycles of 0.04, 0.08, 0.12 and 0.16 s and amplitudes of 0.0025, 0.005, 0.0075 and 0.01 were imported as the inlet velocity of the disperse phase. Droplet sizes and generation times were obtained by simulating different flow processes. The results show that when the cycle is less than 0.08 s, changes of cycle time and amplitude have few effects on droplet size and generation time. However, when the cycle time is larger than 0.08 s, droplet size and generation time change periodically. Furthermore, amplitude has few effects on droplet generation.
  •  
36.
  • Chen, Min Rui, et al. (author)
  • The hydraulic cavitation affected by nanoparticles in nanofluids
  • 2018
  • In: Computation. - : MDPI AG. - 2079-3197. ; 6:3
  • Journal article (peer-reviewed)abstract
    • When liquids flow through a throttling element, the velocity increases and the pressure decreases. At this point, if the pressure is below the saturated vapor pressure of this liquid, the liquid will vaporize into small bubbles, causing hydraulic cavitation. In fact, a vaporization nucleus is another crucial condition for vaporizing, and particles contained in the liquid can also work as the vaporization nuclear. As a novel heat transfer medium, nanofluids have attracted the attention of many scholars. The nanoparticles contained in the nanofluids play a significant role in the vaporization of liquids. In this paper, the effects of the nanoparticles on hydraulic cavitation are investigated. Firstly, a geometric model of a perforated plate, the throttling element in this paper, is established. Then with different nanoparticle volume fractions and diameters, the nanofluids flowing through the perforated plate are numerically simulated based on a validated numerical method. The operation conditions, such as the ratio of inlet to outlet pressures and the temperature are the considered variables. Additionally, cavitation numbers under different operating conditions are achieved to investigate the effects of nanoparticles on hydraulic cavitation. Meanwhile, the contours are extracted to research the distribution of bubbles for further investigation. This study is of interest for researchers working on hydraulic cavitation or nanofluids.
  •  
37.
  • Eatough, Ralph P., et al. (author)
  • Verification of Radiative Transfer Schemes for the EHT
  • 2020
  • In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 897:2
  • Journal article (peer-reviewed)abstract
    • The Event Horizon Telescope (EHT) Collaboration has recently produced the first resolved images of the central supermassive black hole in the giant elliptical galaxy M87. Here we report on tests of the consistency and accuracy of the general relativistic radiative transfer codes used within the collaboration to model M87∗ and Sgr A∗. We compare and evaluate (1) deflection angles for equatorial null geodesics in a Kerr spacetime; (2) images calculated from a series of simple, parameterized matter distributions in the Kerr metric using simplified emissivities and absorptivities; (3) for a subset of codes, images calculated from general relativistic magnetohydrodynamics simulations using different realistic synchrotron emissivities and absorptivities; (4) observables for the 2017 configuration of EHT, including visibility amplitudes and closure phases. The error in total flux is of order 1% when the codes are run with production numerical parameters. The dominant source of discrepancies for small camera distances is the location and detailed setup of the software "camera"that each code uses to produce synthetic images. We find that when numerical parameters are suitably chosen and the camera is sufficiently far away the images converge and that for given transfer coefficients, numerical uncertainties are unlikely to limit parameter estimation for the current generation of EHT observations. The purpose of this paper is to describe a verification and comparison of EHT radiative transfer codes. It is not to verify EHT models more generally.
  •  
38.
  • Elsik, Christine G., et al. (author)
  • The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
  • 2009
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
  • Journal article (peer-reviewed)abstract
    • To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
  •  
39.
  • Feigin, Valery L., et al. (author)
  • Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
  • 2021
  • In: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
  • Journal article (peer-reviewed)abstract
    • Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
  •  
40.
  • Gao, Zhi-Wen, et al. (author)
  • Multifunctional Ion-Lock Interface Layer Achieved by Solid-Solid Contact Approach for Stabilizing Perovskite Solar Cells
  • 2022
  • In: Advanced Functional Materials. - : WILEY-V C H VERLAG GMBH. - 1616-301X .- 1616-3028. ; 32:26
  • Journal article (peer-reviewed)abstract
    • It has been a hindering issue in perovskite solar cells that the interfaces between the perovskite and charge transport layers show significantly high concentrations of defects with an amount about 100 times more than inside the bulk perovskite layer. The issue causes substantial reduction in both the efficiency and stability of the devices. Herein, a solid-solid contact approach is demonstrated to realize a multifunctional ion-lock layer with strong chemical interaction to the perovskite layer. The multifunctional ion-lock layer remarkably suppresses the interface defects and tunes the work function, contributing to promoting the carrier extraction, increasing the open-circuit voltage, and enlarging the photocurrent. In addition, the multifunctional ion-lock layer successfully locks ions from movement and thus improves the stability of the devices. Finally, with a multifunctional ion-lock layer, the perovskite solar cells deliver an efficiency of up to 23.13% along with desirable long-term operational, storage, and humidity stability. Consequently, the work offers guidelines for establishing defect-suppressed interfaces between perovskites and hole transport layers.
  •  
41.
  • Georgiev, Boris, et al. (author)
  • A Universal Power-law Prescription for Variability from Synthetic Images of Black Hole Accretion Flows
  • 2022
  • In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 930:2
  • Journal article (peer-reviewed)abstract
    • We present a framework for characterizing the spatiotemporal power spectrum of the variability expected from the horizon-scale emission structure around supermassive black holes, and we apply this framework to a library of general relativistic magnetohydrodynamic (GRMHD) simulations and associated general relativistic ray-traced images relevant for Event Horizon Telescope (EHT) observations of Sgr A*. We find that the variability power spectrum is generically a red-noise process in both the temporal and spatial dimensions, with the peak in power occurring on the longest timescales and largest spatial scales. When both the time-averaged source structure and the spatially integrated light-curve variability are removed, the residual power spectrum exhibits a universal broken power-law behavior. On small spatial frequencies, the residual power spectrum rises as the square of the spatial frequency and is proportional to the variance in the centroid of emission. Beyond some peak in variability power, the residual power spectrum falls as that of the time-averaged source structure, which is similar across simulations; this behavior can be naturally explained if the variability arises from a multiplicative random field that has a steeper high-frequency power-law index than that of the time-averaged source structure. We briefly explore the ability of power spectral variability studies to constrain physical parameters relevant for the GRMHD simulations, which can be scaled to provide predictions for black holes in a range of systems in the optically thin regime. We present specific expectations for the behavior of the M87* and Sgr A* accretion flows as observed by the EHT.
  •  
42.
  • Gu, Shi-Ran, et al. (author)
  • Phylogeny and re-circumscription of Cheniella (Leguminosae: Cercidoideae) based on plastome data and morphology, with description of three new species
  • 2024
  • In: TAXON. - 0040-0262 .- 1996-8175. ; 73:2, s. 475-502
  • Journal article (peer-reviewed)abstract
    • Subfamily Cercidoideae is an early-diverging lineage of Leguminosae, within which the number and classification of genera have been controversial. Cheniella is a recently described genus in the Cercidoideae which requires revision and testing of its monophyly and circumscription. Here we infer the phylogenetic position and infrageneric relationships of Cheniella as well as the intergeneric relationships of Cercidoideae using 48 newly sequenced plastid genomes, including 34 individuals representing all species of Cheniella. Our phylogenetic analyses yield a well-resolved tree of Cercidoideae with robust support at most nodes. We also present morphological studies through field work and herbarium studies to re-assess the classification and circumscription of the genus. Based on the results of molecular analyses and morphological studies combined with distribution data, we broaden the circumscription of Cheniella to comprise a total of 15 species and 3 subspecies, including three new species (C. hechiensis, C. longistaminea, C. pubicarpa), one new combination (C. tianlinensis) and one new status and combination (C. longipes).
  •  
43.
  • Guo, Junji, et al. (author)
  • Mechanistic Insights into the Coloration, Evolution, and Degradation of NiOx Electrochromic Anodes
  • 2018
  • In: Inorganic Chemistry. - : AMER CHEMICAL SOC. - 0020-1669 .- 1520-510X. ; 57:15, s. 8874-8880
  • Journal article (peer-reviewed)abstract
    • NiOx is recognized as the leading candidate for smart window anodes that can dynamically modulate optical absorption, thereby achieving energy efficiency in construction buildings. However, the electrochromic mechanism in NiOx is not yet clear, and the ionic species involved are sometimes ambiguous, particularly in aprotic electrolytes. We demonstrate herein that the "net coloration effect" originates from newly generated high-valence Ni3+/Ni4+ ions during anion-dependent anodization, and the Li+ intercalation/deintercalation only plays a role in modulating the oxidation state of Ni. Unambiguous evidences proving the occurrence of anodization reaction were obtained by both chronoamperometry and cyclic voltammetry. Benefiting from the irreversible polarization of Ni2+ to Ni3+/Ni4+, the quantity of voltammetric charge increases by similar to 38% under the same test conditions, enhancing the corresponding electrochromic modulation by similar to 8%. Strong linkages between the coloration, evolution, and degradation observed in this work provide in-depth insights into the electrocatalytic and electrochromic mechanisms.
  •  
44.
  • Guo, Junji, et al. (author)
  • Prominent Electrochromism Achieved Using Aluminum Ion Insertion/Extraction in Amorphous WO3 Films
  • 2018
  • In: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 122:33, s. 19037-19043
  • Journal article (peer-reviewed)abstract
    • Although monovalent lithium has been successfully used as a coloring ion in electrochromic applications, it still faces the challenges of low safety, high cost, and limited reserves. Herein, we demonstrate that the amorphous WO3 films intercalated with Al3+ ions could exhibit desired wide optical modulation (similar to 63.0%) and high coloration efficiency (similar to 72.0 cm(2) A(-1), which is >100% higher than that with Li+ or Na+), benefiting from the three-electron redox properties of aluminum. Due to the strong electrostatic force and large atomic weight, the charge exchange processes for Al3+ ions are limited only to the near-surface region and consequently bring about enhanced electrochromic stability. Our findings provide in-depth insights into the nature of electrochromism and also open up a new route toward scalable electrochromic devices using sputtering techniques and earth-abundant materials.
  •  
45.
  • Guo, Junji, et al. (author)
  • Vacancy dependent electrochromic behaviors of NiOx anodes : As a single layer and in devices
  • 2018
  • In: Solar Energy Materials and Solar Cells. - : ELSEVIER SCIENCE BV. - 0927-0248 .- 1879-3398. ; 178, s. 193-199
  • Journal article (peer-reviewed)abstract
    • Electrochromic(EC), nonstoichiometric NiOx thin films were made by reactive magnetron sputtering at low oxygen flow ratio(i.e., P = O-2/Ar + O-2 < 10%). The results of optical spectral, x-ray diffraction spectrum, and x-ray photoelectron spectroscopy analyses indicate that the samples are oxygen(nickel)-deficient as P <= %4(>=%6), resulting in sub(over)-stoichiometry films. Spectroelectrochemical measurements show that the EC effect of NiOx in nonaqueous PC - LiClO4 electrolyte is direct correlation with the nickel vacancy concentration in films, while that in the aqueous KOH solution is nearly uninfluenced upon the change in stoichiometry as P >= %4. The films deposited at P = 6% exhibit higher coloration efficiency of - 25.3 cm(2)C(-1), larger ionic diffusion coefficient of - 2.84 x 10(-14) m(2)s(-1), and broader EC modulation span of 24% in PC - LiClO4 than the other ones. Based upon these values, EC devices featuring a WO3/PMMA - PC - LiClO4/NiOx structure and excellent performances were fabricated. We demonstrated that the nickel anodization should be responsible for the initial "activation" phenomena, which decreases(increases) the number of oxygen(nickel) vacancies. Moreover, the cause of degradation resulting from Li+-ion trapping in the IS layer was also clarified. This work provides a general framework for studying and designing superior EC devices, experimentally as well as theoretically.
  •  
46.
  • He, Leye, et al. (author)
  • Clinical Significance of IL-2, IL-10, and TNF-alpha in Prostatic Secretion of Patients With Chronic Prostatitis
  • 2010
  • In: Urology. - : Elsevier BV. - 0090-4295 .- 1527-9995. ; 75:3, s. 654-657
  • Journal article (peer-reviewed)abstract
    • Objectives To explore the clinical significance of interleukin-2 (IL-2), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-α) in expressed prostatic secretions (EPS) of patients with different types of chronic prostatitis (CP). Methods Fifty-seven CP patients and 12 healthy males (controls) were investigated. The CP patients were evaluated through routine examination of urine, EPS, 2 glasses urine culture, and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score and classified by the NIH prostatitis diagnostic criteria. The levels of cytokines TNF-α, IL-10, and IL-2 in the EPS were measured by two-antibody enzyme-linked immunosorbent assay. Results CP patients fell into 3 groups: type II (n = 10), type IIIa (n = 26), and type IIIb (n = 21). EPS TNF-α and IL-10 levels were significantly higher in type II and type IIIa than in type IIIb and control groups. The levels of IL-2 were lower than control in all CP groups, but only type II was statistically different from the controls. In the CP patients, the level of TNF-α was positively related to the white blood cell counts (r = .77; P <.01), and the level of IL-10 was positively related to the NIH-CPSI scores (r = .55; P <.01). Conclusions Determination of variety expression of TNF-α, IL-10, and IL-2 in the EPS of CP patients may provide a potential indicator for clinical diagnosis classification and an indicator to evaluate the effect of treatment of CP.
  •  
47.
  • He, Wei, et al. (author)
  • China's Terrestrial Carbon Sink Over 2010–2015 Constrained by Satellite Observations of Atmospheric CO2 and Land Surface Variables
  • 2022
  • In: Journal of Geophysical Research: Biogeosciences. - 2169-8953. ; 127:2
  • Journal article (peer-reviewed)abstract
    • The magnitude and distribution of China's terrestrial carbon sink remain uncertain due to insufficient constraints at large scales, whereby satellite data offer great potential for reducing the uncertainty. Here, we present two carbon sink estimates for China constrained either by satellite CO2 column concentrations (XCO2) within the Global Carbon Assimilation System or by remotely sensed soil moisture and Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) in addition to in situ CO2 observations within the Carbon Cycle Data Assimilation System. They point to a moderate size of carbon sinks of 0.34 ± 0.14 (mean ± unc.) and 0.43 ± 0.09 PgC/yr during 2010–2015, which are supported by an inventory-based estimate for forest and soil carbon sink (0.26 PgC/yr) and fall in the range of contemporary ensemble atmospheric inversions (0.25–0.48 PgC/yr). They also agree reasonably well on interannual variations, which reflect the carbon sink anomalies induced by regional droughts in southwest China. Furthermore, their spatial distributions are broadly consistent that of the forest inventory-based estimate, indicating that the largest carbon sinks locate in central and eastern China. Their estimates for forest carbon sink coincide fairly well with the inventory-based estimate across different regions, especially when aggregated to the north and south of China. Although enhanced recently by afforestation, China's carbon sink was also significantly weakened by regional droughts, which were often not fully represented in previous in situ CO2-based inversions due to insufficient observations. Our results suggest that satellite-based atmospheric CO2 and land surface observations are vital in characterizing terrestrial net carbon fluxes at regional scales.
  •  
48.
  • Hu, Li-Peng, et al. (author)
  • Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression
  • 2022
  • In: Molecular Therapy. - : Elsevier BV. - 1525-0024 .- 1525-0016. ; 30:10, s. 3284-3299
  • Journal article (peer-reviewed)abstract
    • Existing evidence indicates that gut fungal dysbiosis might play a key role in the pathogenesis of colorectal cancer (CRC). We sought to explore whether reversing the fungal dysbiosis by terbinafine, an approved antifungal drug, might inhibit the development of CRC. A population-based study from Sweden identified a total of 185 patients who received terbinafine after their CRC diagnosis and found that they had a decreased risk of death (hazard ratio=0.50) and metastasis (hazard ratio=0.44) compared with patients without terbinafine administration. In multiple mouse models of CRC, administration of terbinafine decreased the fungal load, the fungus-induced myeloid-derived suppressor cell (MDSC) expansion, and the tumor burden. Fecal microbiota transplantation from mice without terbinafine treatment reversed MDSC infiltration and partially restored tumor proliferation. Mechanistically, terbinafine directly impaired tumor cell proliferation by reducing the ratio of nicotinamide adenine dinucleotide phosphate (NADP+) to reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), suppressing the activity of glucose-6-phosphate dehydrogenase (G6PD), resulting in nucleotide synthesis disruption, deoxyribonucleotide (dNTP) starvation and cell cycle arrest. Collectively, terbinafine can inhibit CRC by reversing fungal dysbiosis, suppressing tumor cell proliferation, inhibiting fungus-induced MDSC infiltration, and restoring antitumor immune response.
  •  
49.
  • Huang, Shan, et al. (author)
  • Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
  • 2023
  • In: Cellular Oncology. - : Springer Science and Business Media LLC. - 2211-3428 .- 2211-3436. ; 46:4, s. 953-967
  • Journal article (peer-reviewed)abstract
    • PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect of aspirin against CRC could be improved by combined administration with dipyridamole.METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. This therapeutic effect was further verified in different CRC mouse models, i.e. an orthotopic xenograft mouse model, an AOM/DSS mouse model, an Apc min/+ mouse model and a patient derived xenograft (PDX) mouse model. The in vitro effects of the drugs on CRC cells were tested using CCK8 and flow cytometry assays. RNA-Seq, Western blotting, qRT-PCR and flow cytometry were used to identify the underlying molecular mechanisms. RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect.CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. In case further clinical studies confirm our findings, these may be repurposed as adjuvant agents.
  •  
50.
  • Janssen, Michael, et al. (author)
  • Event Horizon Telescope observations of the jet launching and collimation in Centaurus A
  • 2021
  • In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 5:10, s. 1017-1028
  • Journal article (peer-reviewed)abstract
    • Very-long-baseline interferometry (VLBI) observations of active galactic nuclei at millimetre wavelengths have the power to reveal the launching and initial collimation region of extragalactic radio jets, down to 10–100 gravitational radii (rg ≡ GM/c2) scales in nearby sources1. Centaurus A is the closest radio-loud source to Earth2. It bridges the gap in mass and accretion rate between the supermassive black holes (SMBHs) in Messier 87 and our Galactic Centre. A large southern declination of −43° has, however, prevented VLBI imaging of Centaurus A below a wavelength of 1 cm thus far. Here we show the millimetre VLBI image of the source, which we obtained with the Event Horizon Telescope at 228 GHz. Compared with previous observations3, we image the jet of Centaurus A at a tenfold higher frequency and sixteen times sharper resolution and thereby probe sub-lightday structures. We reveal a highly collimated, asymmetrically edge-brightened jet as well as the fainter counterjet. We find that the source structure of Centaurus A resembles the jet in Messier 87 on ~500 rg scales remarkably well. Furthermore, we identify the location of Centaurus A’s SMBH with respect to its resolved jet core at a wavelength of 1.3 mm and conclude that the source’s event horizon shadow4 should be visible at terahertz frequencies. This location further supports the universal scale invariance of black holes over a wide range of masses5,6.
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