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1.	Furtado, R. H. M., et al. (author) Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial 2020 In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 9:10 Journal article (peer-reviewed)abstract BACKGROUND: A proposed cause of dyspnea induced by ticagrelor is an increase in adenosine blood levels. Because caffeine is an adenosine antagonist, it can potentially improve drug tolerability with regard to dyspnea. Furthermore, association between caffeine and cardiovascular events is of clinical interest. METHODS AND RESULTS: This prespecified analysis used data from the PEGASUS TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, which randomized 21 162 patients with prior myocardial infarction to ticagrelor 60 mg or 90 mg or matching placebo (twice daily). Baseline caffeine intake in cups per week was prospectively collected for 9694 patients. Outcomes of interest included dyspnea, major adverse cardiovascular events (ie, the composite of cardiovascular death, myocardial infarction, or stroke), and arrhythmias. Dyspnea analyses considered the pooled ticagrelor group, whereas cardiovascular outcome analyses included patients from the 3 randomized arms. After adjustment, caffeine intake, compared with no intake, was not associated with lower rates of dyspnea in patients taking ticagrelor (adjusted hazard ratio (HR), 0.91; 95% CI, 0.76-1.10; P= 0.34). There was no excess risk with caffeine for major adverse cardiovascular events (adjusted HR, 0.78; 95% CI, 0.63-0.98; P=0.031), sudden cardiac death (adjusted HR, 0.98; 95% CI, 0.57-1.70; P=0.95), or atrial fibrillation (adjusted odds ratio, 1.07; 95% CI, 0.56-2.04; P=0.84). CONCLUSIONS: In patients taking ticagrelor for secondary prevention after myocardial infarction, caffeine intake at baseline was not associated with lower rates of dyspnea compared with no intake. Otherwise, caffeine appeared to be safe in this population, with no apparent increase in atherothrombotic events or clinically significant arrhythmias.
2.	Bonaca, M. P., et al. (author) Reduction in subtypes and sizes of myocardial infarction with ticagrelor in PEGASUS-TIMI 54 2018 In: Journal of the American Heart Association. - 2047-9980. ; 7:22 Journal article (peer-reviewed)abstract Background-—Ticagrelor reduced cardiovascular death, myocardial infarction (MI), or stroke in patients with prior MI in PEGASUSTIMI 54 (Prevention of Cardiovascular Events [eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke] in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin). MI can occur in diverse settings and with varying severity; therefore, understanding the types and sizes of MI events prevented is of clinical importance. Methods and Results-—MIs were adjudicated by a blinded clinical events committee and categorized by subtype and fold elevation of peak cardiac troponin over the upper limit of normal. A total of 1042 MIs occurred in 898 of the 21 162 randomized patients over a median follow-up of 33 months. The majority of the MIs (76%) were spontaneous (Type 1), with demand MI (Type 2) and stent thrombosis (Type 4b) accounting for 13% and 9%, respectively; sudden death (Type 3), percutaneous coronary intervention–related (Type 4a) and coronary artery bypass graft–related (Type 5) each accounted for <1%. Half of MIs (520, 50%) had a peak troponin ≥10x upper limit of normal and 21% of MIs (220) had a peak troponin ≥1009 upper limit of normal. A total of 21% (224) were ST-segment–elevation MI STEMI. Overall ticagrelor reduced MI (4.47% versus 5.25%, hazard ratio 0.83, 95% confidence interval 0.72–0.95, P=0.0055). The benefit was consistent among the subtypes, including a 31% reduction in MIs with a peak troponin ≥1009 upper limit of normal (hazard ratio 0.69, 95% confidence interval 0.53–0.92, P=0.0096) and a 40% reduction in ST-segment elevation MI (hazard ratio 0.60, 95% confidence interval 0.46–0.78, P=0.0002). Conclusions-—In stable outpatients with prior MI, the majority of recurrent MIs are spontaneous and associated with a high biomarker elevation. Ticagrelor reduces the MI consistently among subtypes and sizes including large MIs and ST-segment elevation MI. Clinical Trial Registration-URL: https://www.clinicaltrials.gov. Unique identifier: NCT01225562. © 2018 The Authors.
3.	Johanson, Per, 1963, et al. (author) An academic ECG core lab perspective of the FDA initiative for digital ECG capture and data management in large-scale clinical trials 2005 In: Drug Information Journal. - 0092-8615. ; 39:4, s. 345-351 Journal article (peer-reviewed)abstract Maximal utility of accessible data is attractive to all partners in clinical research, whether it directly improves patient care or more accurately allows identification of the safety and efficacy of a new drug or procedure. The Food and Drug Administration (FDA) has presented a guideline draft addressing digitization of electrocardiogram (ECG) data in clinical trials to improve the standards for collection, analysis, and storage of safety information on new medical therapies. This FDA initiative has led to discussions and collaboration among the FDA, the pharmaceutical industry, the electrocardiographj, manufacturers, and the academic as well as the nonacademic EGG core labs. In this article, we present a broad-based viewpoint from two groups of academic EGG core labs, the Alliance of Academic EGG Core Labs and the Virtual Electronic EGG Corelab International Consortium. We have chosen to widen the perspective from using digitized EGG data in safety trials only, as addressed by the FDA guideline draft, to a discussion on the possibilities and the potential problems when using digitized EGG data also in large clinical trials focusing on efficacy measurements. We conclude that the benefit of digital data mining is probably well worth an initial incremental effort and expense.
4.	Thunes, Karl H., et al. (author) The arthropod community of Scots pine (Pinus sylvestris L.) canopies in Norway 2004 In: Entomologica Fennica. - 0785-8760. ; 15, s. 65-90 Journal article (peer-reviewed)
5.	Davies, Thomas G., et al. (author) Open data and digital morphology. 2017 In: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 284:1852, s. 1-10 Journal article (peer-reviewed)abstract Over the past two decades, the development of methods for visualizing and analysing specimens digitally, in three and even four dimensions, has transformed the study of living and fossil organisms. However, the initial promise that the widespread application of such methods would facilitate access to the underlying digital data has not been fully achieved. The underlying datasets for many published studies are not readily or freely available, introducing a barrier to verification and reproducibility, and the reuse of data. There is no current agreement or policy on the amount and type of data that should be made available alongside studies that use, and in some cases are wholly reliant on, digital morphology. Here, we propose a set of recommendations for minimum standards and additional best practice for three-dimensional digital data publication, and review the issues around data storage, management and accessibility.
6.	Dellborg, Mikael, 1954, et al. (author) Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. 2019 In: European heart journal. Cardiovascular pharmacotherapy. - : Oxford University Press (OUP). - 2055-6845 .- 2055-6837. ; 5:4, s. 200-206 Journal article (peer-reviewed)abstract In PEGASUS-TIMI 54, ticagrelor significantly reduced the risk of the composite of major adverse cardiovascular (CV) events by 15-16% in stable patients with a prior myocardial infarction (MI) 1-3years earlier. We report the efficacy and safety in the subpopulation recommended for treatment in the European (EU) label, i.e. treatment with 60mg b.i.d. initiated up to 2years from the MI, or within 1 year after stopping previous adenosine diphosphate receptor inhibitor treatment.Of the 21162 patients enrolled in PEGASUS-TIMI 54, 10779 patients were included in the primary analysis for this study, randomized to ticagrelor 60mg (n=5388) or matching placebo (n=5391). The cumulative proportions of patients with events at 36months were calculated by the Kaplan-Meier (KM) method. The composite of CV death, MI, or stroke occurred less frequently in the ticagrelor group (7.9% KM rate vs. 9.6%), hazard ratio (HR) 0.80 [95% confidence interval (CI) 0.70-0.91; P=0.001]. Ticagrelor also reduced the risk of all-cause mortality, HR 0.80 (0.67-0.96; P=0.018). Thrombolysis in myocardial infarction major bleeding was more frequent in the ticagrelor group 2.5% vs. 1.1%; HR 2.36 (1.65-3.39; P<0.001). The corresponding HR for fatal or intracranial bleeding was 1.17 (0.68-2.01; P=0.58).In PEGASUS-TIMI 54, treatment with ticagrelor 60mg as recommended in the EU label, was associated with a relative risk reduction of 20% in CV death, MI, or stroke. Thrombolysis in myocardial infarction major bleeding was increased, but fatal or intracranial bleeding was similar to placebo. There appears to be a favourable benefit-risk ratio for long-term ticagrelor 60mg in this population.http://www.clinicaltrials.gov NCT01225562.
7.	Koutouzis, M, et al. (author) Acute coronary syndromes in nonagenarians in Sweden. A report from the register of Information and Knowledge about Swedish Seart Intensive care Admissions (RIKS-HIA) in EUROPEAN HEART JOURNAL, vol 31, issue , pp 308-308 2010 In: EUROPEAN HEART JOURNAL. - : Oxford University Press. ; , s. 308-308 Conference paper (peer-reviewed)abstract n/a
8.	Malmi, Teemu, et al. (author) Culture and management control interdependence : An analysis of control choices that complement the delegation of authority in Western cultural regions 2020 In: Accounting, Organizations and Society. - : Elsevier Ltd. - 0361-3682 .- 1873-6289. Journal article (peer-reviewed)abstract This study examines the influence of cultural regions on the interdependence between delegation of authority and other management control (MC) practices. In particular, we assess whether one of the central contentions of agency theory, that incentive contracting and delegation are jointly determined, holds in different cultural regions. Drawing on prior literature, we hypothesise that the MC practices that operate as a complement to delegation vary depending on societal values and preferences, and that MC practices other than incentive contracting will complement delegation in firms in non-Anglo cultural regions. Using data collected from 584 strategic business units across three Western cultural regions (Anglo, Germanic, Nordic), our results show that the interdependence between delegation and incentive contracting is confined to Anglo firms. In the Nordic and Germanic regions, we find that strategic and action planning participation operate as a complement to delegation, while delegation is also complemented by manager selection in Nordic firms. Overall, our study demonstrates that cultural values and preferences significantly influence MC interdependence, and suggests that caution needs to be taken in making cross-cultural generalisations about the complementarity of MC practices.
9.	Andersson, P, et al. (author) Internalization of indium-111 into human neuroendocrine tumor cells after incubation with indium-111-DTPA-D-Phe1-octreotide. 1996 In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 0161-5505. ; 37:12, s. 2002-6 Journal article (peer-reviewed)abstract Neuroendocrine tumor cells frequently overexpress somatostatin receptors at their cell surfaces. To evaluate the possibility of using the somatostatin analog 111In-DTPA-D-Phe1-octreotide for radiation therapy, we studied the binding and subsequent internalization of 111In into three types of cultured human neuroendocrine tumor cells.
10.	Betsch, A, et al. (author) Observation of strong final-state effects in pi(+) production in pp collisions at 400 MeV 1999 In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 446:2, s. 179-184 Journal article (peer-reviewed)abstract Differential cross sections of the reactions pp --> d pi(+) and pp --> pn pi(+) have been measured at T-p = 400 MeV by detecting the charged ejectiles in the angular range 4 degrees less than or equal to Theta(Lab) less than or equal to 21 degrees. The de
11.	Bilger, R, et al. (author) 2 pi production in pp collisions close to threshold 2000 In: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. ; , s. 469C-472C Conference paper (peer-reviewed)abstract The reaction pp --> NN pi pi has been measured close to threshold in the energy range from 650 to 775 MeV using the PROMICE/WASA setup at CELSIUS. These data constitute the first exclusive high-statistics measurements of this reaction on a pure hydrogen t
12.	Bilger, R, et al. (author) Cross sections of the pp -> pp pi(0) reaction between 310 and 425 MeV 2001 In: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 693:3-4, s. 633-662 Journal article (peer-reviewed)abstract Extensive kinematically complete measurements of the pp --> pp pi (0) reaction have been made at six beam energies: 310, 320, 340, 360, 400, and 425 MeV. Angles and energies of both final-state protons are extracted from the forward detector system of the
13.	Bilger, R, et al. (author) Spectator tagging in quasi-free pn-reactions on deuterium at PROMICE/WASA, CELSIUS 2000 In: Nuclear Physics A. - : Elsevier Science B.V. Holland. ; , s. 1053c-1056c Conference paper (peer-reviewed)abstract A set of silicon detectors has been added to the PROMICE/WASA (P/W) experiment at CELSIUS. These detectors have been used for spectator-proton tagging in proton deuteron collisions to investigate proton-neutron reactions at intermediate energies. The perf
14.	Bilger, R, et al. (author) Spectator tagging in quasi-free proton-neutron interactions in deuterium using an internal cluster-jet target at a storage ring 2001 In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 457:1-2, s. 64-74 Journal article (peer-reviewed)abstract Low-energy spectator protons (p(s)) from quasi-free proton-neutron interactions on deuterium have been measured for the pd --> d pi (0)p(s) and pd --> pn pi (0)p(s) reactions at the CELSIUS storage ring of the The Svedberg Laboratory. The experiment used
15.	Bilger, R, et al. (author) Spectator Tagging in Quasi-Free Reactions 2000 In: Nuclear Physics A. ; , s. 1053c- Conference paper (peer-reviewed)
16.	Bilger, R, et al. (author) Threshold eta production in pN reactions at Celsius 1998 In: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. ; , s. 2981-2985 Conference paper (peer-reviewed)abstract The quasi-free p+n-->d+eta reaction cross section has been measured at threshold using 1295 MeV protons in the CELSIUS storage ring and an internal cluster-jet deuterium target [1]. Excess energies from threshold to 10 MeV in the center of mass of the fin
17.	Bilger, R, et al. (author) Two-pion production in proton-proton collisions near threshold at Celsius 1998 In: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. ; , s. 2987-2991 Conference paper (peer-reviewed)abstract Two-pion production reactions in proton-proton collisions near threshold are measured using an internal cluster-jet hydrogen target and the WASA/PROMICE detector at the CELSIUS storage ring. Four out of the five possible two-pion production reactions are
18.	Brodowski, W, et al. (author) Exclusive measurement of pp -> pp pi(+)pi(-) at CELSIUS 2000 In: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 31:10-11, s. 2295-2298 Journal article (peer-reviewed)abstract With the PROMICE/WASA detector setup at CELSIUS the reaction pp --> NN pi pi has been measured in the energy range from 650 to 775 MeV. These data constitute the first exclusive high-statistics measurements on a pure hydrogen target, supplying both differ
19.	Brodowski, W, et al. (author) Exclusive Measurements of pp -> pp pi+ pi- at CELSIUS 2000 In: ACTA PHYSICA POLONICA B. ; , s. 2295- Conference paper (peer-reviewed)
20.	Brodowski, W, et al. (author) Exclusive Measurements of the pp -> pp pi+pi- Reaction Close to Threshold 2001 In: AIP Conference Proceedings. ; , s. 503- Conference paper (peer-reviewed)
21.	Calen, H, et al. (author) Threshold structure of the quasifree p+n -> d+eta reaction 1998 In: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 80:10, s. 2069-2072 Journal article (peer-reviewed)abstract The quasifree p + n --> d + eta reaction cross section has been measured at the threshold using 1295 MeV protons in the CELSIUS storage ring and an internal cluster-jet deuterium target. The kinematics is chosen such that the target proton can be assumed
22.	Carlsbecker, A, et al. (author) The DAL10 gene from Norway spruce (Picea abies) belongs to a potentially gymnosperm-specific subclass of MADS-box genes and is specifically active in seed cones and pollen cones. 2003 In: Evolution & Development. - 1525-142X. ; 5:6, s. 551-561 Journal article (peer-reviewed)abstract Transcription factors encoded by different members of the MADS-box gene family have evolved central roles in the regulation of reproductive organ development in the flowering plants, the angiosperms. Development of the stamens and carpels, the pollen- and seed-bearing organs, involves the B- and C-organ-identity MADS-box genes. B- and C-type gene orthologs with activities specifically in developing pollen- and seed-bearing organs are also present in the distantly related gymnosperms: the conifers and the gneto-phytes. We now report on the characterization of DAL10, a novel MADS-box gene from the conifer Norway spruce, which unlike the B- and C-type conifer genes shows no distinct orthology relationship to any angiosperm gene or clade in phylogenetic analyses. Like the B- and C-type genes, it is active specifically in developing pollen cones and seed cones. In situ RNA localization experiments show DAL10 to be expressed in the cone axis, which carry the microsporophylls of the young pollen cone. In contrast, in the seed cone it is expressed both in the cone axis and in the bracts, which subtend the ovuliferous scales. Expression data and the phenotype of transgenic Arabidopsis plants expressing DAL10 suggest that the gene may act upstream to or in concert with the B- and C-type genes in the establishment of reproductive identity of developing cones.
23.	Dowdy, L., et al. (author) Aborted infarction: the ultimate myocardial salvage 2004 In: Am Heart J. - 1097-6744. ; 147:3, s. 390-4 Journal article (peer-reviewed)
24.	Edwards, DA, et al. (author) Hydration for Clean Air Todaya 2021 In: Molecular Frontiers journal. - 2529-7333. ; 5:1-2, s. 1-4 Journal article (peer-reviewed)
25.	Fjalldal, S., et al. (author) Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma 2018 In: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 178:6, s. 577-587 Journal article (peer-reviewed)abstract Context: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown. Objective: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP. Design: A cross-sectional study with a median follow-up time of 22 (6-49) years after operation. Setting: The South Medical Region of Sweden (2.5 million inhabitants). Participants: Included were 41 patients (24 women, amp;gt;= 17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HI was found in 23 patients. Main outcome measures: Subjects performed cognitive tests and magnetic resonance imaging, and images were analyzed using DTI of uncinate fasciculus, fornix, cingulum, hippocampus and hypothalamus as well as hippocampal volumetry. Results: Right uncinate fasciculus was significantly altered (P amp;lt;= 0.01) Microstructural WM alterations in left ventral cingulum were significantly associated with worse performance in visual episodic memory, explaining approximately 50% of the variation. Alterations in dorsal cingulum were associated with worse performance in immediate, delayed recall and recognition, explaining 26-38% of the variation, and with visuospatial ability and executive function, explaining 19-29%. Patients who had smaller hippocampal volume had worse general knowledge (P = 0.028), and microstructural WM alterations in hippocampus were associated with a decline in general knowledge and episodic visual memory. Conclusions: A structure to function relationship is suggested between microstructural WM alterations in cingulum and in hippocampus with cognitive deficits in CP.
26.	Greiff, J, et al. (author) Pion production in dp -> dN pi reactions with deuteron projectiles - art. no. 064002 2000 In: PHYSICAL REVIEW C. - : AMERICAN PHYSICAL SOC. - 0556-2813. ; 6206:6, s. 4002- Journal article (peer-reviewed)abstract Kinematically complete events have been studied for the reactions dp-->dp pi (0) and dp-->dn pi (+) at projectile energies between 437 and 559 MeV. The measurement covers a range of pion momenta eta =p(pi ,c.m.)(max)/m(pi)c from near the production thresh
27.	Hall, P, et al. (author) [Increased number of cancer cases following computer tomography in children. Radiation dosage--and cancer risk--can be reduced] 2005 In: Lakartidningen. - 0023-7205. ; 102:4, s. 214-5 Journal article (peer-reviewed)
28.	Haq, M., et al. (author) Human capital resources creation and utilization in ethnic minority microbusinesses : The construction of a culture-induced entrepreneurship model 2024 In: Journal of the International Council for Small Business. - : Routledge. - 2643-7015 .- 2643-7023. ; 5:2, s. 106-116 Journal article (peer-reviewed)abstract We explored and found that a set of key resources, that we call human capital resources, play an important role in ethnic minority microbusinesses in an ethnic majority social and economic space. We have also found that these key resources are developed and maintained within the coethnic niche economic space shaped by coethnic cultural value systems. Building on qualitative interview data and drawing on Bourdieu’s forms of capital and the resource-based view of the firm, our study presents a novel microentrepreneurship model that we call the culture-induced entrepreneurship model. Overall, our model provides insights into how ethnic minority culture informs the creation of a set of human capital resources and how these key resources contribute to business performance in regional ethnic minority microbusinesses. Our model also shows relationships between these key human capital resources. © 2023 International Council for Small Business.
29.	Jernberg, T, et al. (author) [Riks-HIA will develop a new index for areas with room for improvement] 2012 In: Lakartidningen. - 0023-7205. ; 109:13, s. 672-3 Journal article (peer-reviewed)
30.	Johanson, Aki, et al. (author) Long-term follow-up in depressed patients treated with ECT 2005 In: Journal of ECT. - 1533-4112. ; 21:4, s. 214-220 Journal article (peer-reviewed)abstract Design: The aim was to study the long-term effects of electroconvulsive therapy (ECT) in depression. 55 patients were followed-up 20-24 years after an ECT series. 13 patients were still alive and 10 agreed to participate in the study. All 55 patients had been investigated with clinical and neuropsychological assessment and with neurophysiological measurements; regional Cerebral Blood Flow (rCBF) and EEG before the first ECT, six months later and after about one year. These investigations were now repeated in the 10 patients. Results: Before the original ECT series all patients had suffered from severe mood disorder. At the follow-up the 10 patients showed no clear signs of mood disorder or cognitive impairment. There was a slightly subnormal performance in working memory and in verbal as well as visual episodic memory on all three occasions after the ECT series. The rCBF measurement showed a significant average CBF decrease from the first to the last measurement. There was, moreover, a significant rCBF decrease in frontal areas at the last measurement compared to the three previous assessments. Conclusion: All ten patients followed-up 20 – 24 years after an ECT series were mentally healthy and thus besides a moderate visual memory dysfunction no severe side effects were observed with clinical and neuroimaging techniques.
31.	Johanson, G., et al. (author) A scoping review of evaluations of and recommendations for default uncertainty factors in human health risk assessment 2023 In: Journal of Applied Toxicology. - : Wiley. - 0260-437X .- 1099-1263. ; 43:1, s. 186-194 Journal article (peer-reviewed)abstract Uncertainty factors (UFs) are used to account for uncertainties and variability when setting exposure limits or guidance values. Starting from a proposal of a single UF of 100 to extrapolate from an animal NOAEL to a human acceptable exposure, the aspects of uncertainty and number of UFs have diversified and today there are several risk assessment guidelines that contain schemes of default UFs of varying complexity. In the present work, we scoped the scientific literature on default UFs to map developments regarding recommendations and evaluations of these. We identified 91 publications making recommendations for one or several UFs and 55 publications evaluating UFs without making explicit recommendations about numerical values; these were published between 1954 and 2021. The 2000s was the decade with the largest number of publications, interspecies differences and intraspecies variability being the most frequent topics. The academic sector has been the most active (76 out of 146 publications). Authors from the private sector more often presented UF recommendations, but differences between sectors regarding size of recommendations were not statistically significant. The empirical underpinning of the reviewed recommendations ranges from four to 462 chemicals, that is, relatively low numbers compared with the range of chemicals these default UFs are expected to cover. The recommended UFs have remained remarkably constant, with merely a slight decrease over time. Although chemical specific UFs are preferable, the widespread use of default UFs warrants further attention regarding their empirical and normative basis.
32.	Johanson, G., et al. (author) Quantitative relationships of perfluoroalkyl acids in drinking water associated with serum concentrations above background in adults living near contamination hotspots in Sweden 2023 In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 219 Journal article (peer-reviewed)abstract Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quantitative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PFPeA, PFHxA, PFHpA, and PFBS) and long-chained PFAAs (PFOA, PFNA, PFDA, PFHxS and PFOS) were measured in DW and serum. We matched DW and serum concentrations for a total of 398 subjects living or working in areas receiving contaminated DW and in one non-contaminated area. Thereafter, linear regression analysis with and without adjustments for co-variates was conducted. This enabled to derive (i) serum concentrations at background exposure (CB) from sources other than local DW exposure (i.e. food, dust and textiles) at 0 ng/L DW concentration, (ii) population-mean PFAA serum:water ratios (SWR) and (iii) PFAA concentrations in DW causing observable elevated serum PFAA concentrations above background variability. Median concentrations of the sum of nine PFAAs ranged between 2.8 and 1790 ng/L in DW and between 7.6 and 96.9 ng/mL in serum. DW concentration was the strongest predictor, resulting in similar unadjusted and adjusted regression coefficients. Mean CB ranged from <0.1 (PFPeA, PFHpA, PFBS) to 5.1 ng/mL (PFOS). Serum concentrations increased significantly with increasing DW concentrations for all PFAAs except for PFPeA with SWRs ranging from <10 (PFHxA, PFHpA and PFBS) to 111 (PFHxS). Observed elevated serum concentrations above background variability were reached at DW concentrations between 24 (PFOA) and 357 ng/L (PFHxA). The unadjusted linear regression predictions agreed well with serum concentrations previously reported in various populations exposed to low and high DW levels of PFOA, PFHxS and PFOS. The quantitative relationships derived herein should be helpful to translate PFAA concentrations in DW to concentrations in serum at the population level.
33.	Johanson, Per, 1963, et al. (author) A dynamic model forecasting myocardial infarct size before, during, and after reperfusion therapy: an ASSENT-2 ECG/VCG substudy 2005 In: Eur Heart J. - : Oxford University Press (OUP). - 0195-668X. ; 26:17, s. 1726-33 Journal article (peer-reviewed)abstract AIMS: Serial forecasts of final myocardial infarct (MI) size during fibrinolytic treatment (Rx) of ST-elevation MI would allow the identification of high-risk patients with a predicted major loss of viable myocardium, at a point when treatment may still be modified. We investigated a model for such forecasting, using time and the ECG. METHODS AND RESULTS: We collected 234 patients with ST-elevation MI, without signs of previous MI, bundle branch block, or hypertrophy. MI size was determined by the Selvester score and was "forecasted" at: admission with patients stratified by delay time and an ECG acuteness score into three groups (EARLY, DISCORDANT, and LATE); 90 min after Rx by > or =70% ST-recovery or not and occurrence of "reperfusion peaks"; 4 h after Rx by ST re-elevations. EARLY patients had smaller final infarct sizes than LATE (9.4 vs. 20%, P=0.01). EARLY patients with > or =70% ST-recovery without a reperfusion peak had smaller infarct sizes than those with (3.1 vs. 12.5%, P=0.001). EARLY patients without ST re-elevations had smaller infarct sizes (1.5%) than those with some (9%) or many re-elevations (12%), P<0.001. CONCLUSION: Final infarct size can be forecasted using delay time and serial ECGs. Serially updated forecasts seem especially important when both clock-time and initial ECG- signs indicate earliness.
34.	Johanson, P, et al. (author) Myocardial reperfusion by ST-segment recovery in patients randomized to either prehospital fibrinolysis or facilitated PCI - A SWEDES substudy 2004 In: CIRCULATION. - 0009-7322. ; 110:17, s. 339-339 Conference paper (other academic/artistic)
35.	Kjellman, MM, et al. (author) Plasma protein fingerprinting and machine learning for the diagnosis of small intestinal neuroendocrine tumors: The nordic NET biomarker group EXPLAIN study 2017 In: ANNALS OF ONCOLOGY. - 0923-7534. ; 28 Conference paper (other academic/artistic)
36.	Kjellman, M., et al. (author) Plasma Protein Fingerprinting for the Diagnosis of Small Intestinal Neuroendocrine Tumors (siNETs) 2017 In: Neuroendocrinology. - : KARGER. - 0028-3835 .- 1423-0194. ; 105, s. 148-148 Journal article (other academic/artistic)
37.	Laux, P, et al. (author) Biokinetics of Nanomaterials: the Role of Biopersistence 2017 In: NanoImpact. - : Elsevier BV. - 2452-0748. ; 6, s. 69-80 Journal article (peer-reviewed)
38.	Laux, P, et al. (author) Challenges in characterizing the environmental fate and effects of carbon nanotubes and inorganic nanomaterials in aquatic systems 2018 In: ENVIRONMENTAL SCIENCE-NANO. - : Royal Society of Chemistry (RSC). - 2051-8153 .- 2051-8161. ; 5:1, s. 48-63 Research review (other academic/artistic)abstract Characterization of carbon nanotube dispersions requires measurement of both, concentration and surface area.
39.	Manno, M, et al. (author) Silica, silicosis and lung cancer: what level of exposure is acceptable? 2018 In: La Medicina del lavoro. - 0025-7818. ; 109:6, s. 478-480 Journal article (peer-reviewed)
40.	Melki, D, et al. (author) CLINICAL EFFECTS OF INTRODUCING HIGH SENSITIVE CARDIAC TROPONIN T INTO CLINICAL PRACTICE: DATA FROM 48,594 PATIENTS IN THE SWEDEHEART REGISTRY 2014 In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - 0735-1097. ; 63:12, s. A17-A17 Conference paper (other academic/artistic)
41.	Molnár, F., et al. (author) Boron, sulphur and copper isotope systematics in the orogenic gold deposits of the Archaean Hattu schist belt, eastern Finland 2016 In: Ore Geology Reviews. - : Elsevier BV. - 0169-1368 .- 1872-7360. ; 77, s. 133-162 Journal article (peer-reviewed)abstract The Hattu schist belt is located in the western part of the Archaean Karelian domain of the Fennoscandian Shield. The orogenic gold deposits with Au–Bi–Te geochemical signatures are hosted by NE–SW, N–S and NW–SE oriented shear zones that deform 2.76–2.73 Ga volcanic and sedimentary sequences, as well as 2.75–2.72 Ga tonalite–granodiorite intrusions and diverse felsic porphyry dykes. Mo–W mineralization is also present in some tonalite intrusions, both separate from, and associated with Au mineralization. Somewhat younger, unmineralized leucogranite intrusions (2.70 Ga) also intrude the belt. Lower amphibolite facies peak metamorphism at 3–5 kbar pressures and at 500–600 °C temperatures affected the belt at around 2.70 Ga and post-date hydrothermal alteration and ore formation. In this study, we investigated the potential influence of magmatic-hydrothermal processes on the formation of orogenic gold deposits on the basis of multiple stable isotope (B, S, Cu) studies of tourmaline and sulphide minerals by application of in situ SIMS and LA ICP MS analytical techniques.Crystal chemistry of tourmaline from a Mo–W mineralization hosted by a tonalite intrusion in the Hattu schist belt is characterized by Fe3 +–Al3 +-substitution indicating relatively oxidizing conditions of hydrothermal processes. The range of δ11B data for this kind of tourmaline is from − 17.2‰ to − 12.2‰. The hydrothermal tourmaline from felsic porphyry dyke swith gold mineralization has similar crystal chemistry (e.g. dravite–povondraite compositional trend with Fe3 +–Al3 + substitution) and δ11B values between − 19.0‰ and − 9.6‰. The uvite–foitite compositional trend and δ11B ‰ values between − 24.1% and − 13.6% characterize metasomatic–hydrothermal tourmaline from the metasediment-hosted gold deposits. Composition of hydrothermal vein-filling and disseminated tourmaline from the gold-bearing shear zones in metavolcanic rocks is transitional between the felsic intrusion and metasedimentary rock hosted hydrothermal tourmaline but the range of average boron isotope data is essentially identical with that of the metasediment-hosted tourmaline. Rock-forming (magmatic) tourmaline from leucogranite has δ11B values between − 14.5‰ and − 10.8‰ and the major element composition is similar to that of the metasediment-hosted tourmaline.The range of δ34SVCDT values measured in pyrite, chalcopyrite and pyrrhotite is from − 9.1 to + 8.5‰, which falls within the typical range of sulphur isotope data for Archaean orogenic gold deposits. In the Hattu schist belt, positive δ34SVCDT values characterize metasediment-hosted gold ores with sulphide parageneses dominated by pyrrhotite and arsenopyrite. The δ34SVCDT values are both positive and negative in ore mineral parageneses within felsic intrusive rocks in which variable amounts of pyrrhotite are associated with pyrite. Purely negative values were only recorded from the pyrite-dominated gold mineralization within metavolcanic units. Therefore the shift of δ34SVCDT values to the negative values reflects precipitation of sulphide minerals from relatively oxidizing fluids. The range of measured δ65CuNBS978 values from chalcopyrite is from − 1.11 to 1.19‰. Positive values are common for mineralization in felsic intrusive rocks and negative values are more typical for deposits confined to metasedimentary rocks. Positive and negative δ65CuNBS978 values occur in the ores hosted by metavolcanic rocks. There is no correlation between sulphur and copper isotope data obtained in the same chalcopyrite grains.Evaluation of sulphur and boron isotope data together and comparisons with other Archaean orogenic gold provinces supports the hypothesis that the metasedimentary rocks were the major sources of sulphur and boron in the orogenic gold deposits in the Hattu schist belt. Variations in major element and boron isotope compositions in tourmaline, as well as in the δ34SVCDT values in sulphide minerals are attributed to localized involvement of magmatic fluids in the hydrothermal processes. The results of copper isotope studies indicate that local sources of copper in orogenic gold deposits may potentially be recognized if the original, distinct signatures of the sources have not been homogenized by widespread interaction of fluids with a large variety of rocks and provided that local chemical variations have been too small to trigger changes in the oxidation state of copper during hydrothermal processes.
42.	Mårtensson, Jonas, et al. (author) Field transmission using Fiber Bragg grating-based dispersion compensating modules with continuous response over the full C-band 2006 In: 2006 European Conference on Optical Communications Proceedings, ECOC 2006. - 9782912328397 Conference paper (peer-reviewed)abstract Fiber Bragg grating-based dispersion compensating modules with continuous response over the full C-band are demonstrated. Group delay characteristics are analysed and modules are used in 10-Gbit/s and 40-Gbit/s field experiments over 820 km installed fiber.
43.	Nelwan, S. P., et al. (author) Assessment of derived 12-lead electrocardiograms using general and patient-specific reconstruction strategies at rest and during transient myocardial ischemia 2004 In: Am J Cardiol. - 0002-9149. ; 94:12, s. 1529-33 Journal article (peer-reviewed)abstract Twelve-lead ST-segment monitoring is a widely used tool for capturing focal ischemia and transient intermittent episodes. However, continuous registration of all 10 electrodes is impractical in clinical settings. This study investigated the accuracy of 2 derived 12-lead strategies that required 6 electrodes, including all limb leads, and 2 precordial leads by using population-based (generalized) and individualized (patient-specific) reconstruction coefficients to derive the additional 4 chest leads. A total of 26,880 simultaneous digital conventional 12-lead generalized and patient-specific electrocardiograms were monitored over 112 hours in 39 patients during percutaneous coronary intervention, including 159 balloon occlusions in 63 arteries, to test accuracy at rest and during ischemia. Occlusion duration was 78 seconds (range 42 to 96) in the left main coronary in 2 patients, the left anterior descending artery in 15, the right coronary artery in 10, the circumflex artery in 2, and graft segments in 5 patients. Average summated 12-lead ST deviation over the study population at baseline was 377 microV (range 104 to 1,718), which increased at peak ischemia to an average of 1,086 microV (range 282 to 4,099). Median absolute differences at peak ischemic ST deviation were 25 microV in lead V(1), 0 microV in lead V(2), 35 microV in lead V(3), 34 microV in lead V(4), 0 microV in lead V(5), 11 microV in lead V(6), and 114 microV for summated 12-lead ST deviation with the generalized method and 7 microV in lead V(1), 4 microV in lead V(2), 1 muV in lead V(3), 5 microV in lead V(4), 4 microV in lead V(5), 9 microV in lead V(6), and 83 microV for the summated 12-lead ST deviation with the patient-specific method. Limb leads (I, II, III, aVR, aVL, and aVF) were identical in all patients. Thus, generalized and patient-specific methods derived from 12-lead electrocardiography using actual limb and 2 precordial electrodes accurately derived the additional chest leads at rest and during ischemia. These approaches appear to be more practical than conventional 10-electrode monitoring but preserve high accuracy.
44.	Nyström-Kandola, Jennifer, et al. (author) Low concentrations of perfluoroalkyl acids (PFAAs) in municipal drinking water associated with serum PFAA concentrations in Swedish adolescents 2023 In: Environment International. - 0160-4120 .- 1873-6750. ; 180 Journal article (peer-reviewed)abstract While highly contaminated drinking water (DW) is a major source of exposure to perfluoroalkyl acids (PFAAs), the contribution of low-level contaminated DW (i.e. < 10 ng/L of individual PFAAs) to PFAA body burdens has rarely been studied. To address this knowledge gap, we evaluated the association between concentrations of perflurooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS), and their sum (∑4PFAAs) in DW and serum in Swedish adolescents using weighted least squares regression. We paired serum PFAA concentrations in adolescents (age 10–21 years, n = 790) from the dietary survey Riksmaten Adolescents 2016–17 (RMA) with mean PFAA concentrations in water samples collected in 2018 from waterworks (n = 45) supplying DW to the participant residential and school addresses. The median concentrations of individual PFAAs in DW were < 1 ng/L. Median concentrations of PFNA and PFHxS in serum were < 1 ng/g, while those of PFOA and PFOS were 1–2 ng/g. Significant positive associations between PFAA concentrations in DW and serum were found for all four PFAAs and ∑4PFAAs, with estimated serum/DW concentration ratios ranging from 210 (PFOA) to 670 (PFHxS), taking exposure from sources other than DW (background) into consideration. The mean concentrations of PFHxS and ∑4PFAA in DW that would likely cause substantially elevated serum concentrations above background variation were estimated to 0.9 ng/L and 2.4 ng/L, respectively. The European Food Safety Authority has determined a health concern concentration of 6.9 ng ∑4PFAAs/mL serum. This level was to a large degree exceeded by RMA participants with DW ∑4PFAA concentrations above the maximum limits implemented in Denmark (2 ng ∑4PFAAs/L) and Sweden (4 ng ∑4PFAAs/L) than by RMA participants with DW concentrations below the maximum limits. In conclusion, PFAA exposure from low-level contaminated DW must be considered in risk assessment for adolescents.
45.	Pätzold, J, et al. (author) Exclusive Measurements of the pp -> pppi+pi- Reaction 2001 In: Proc. MENU 2001, Washington D.C., USA. Conference paper (other academic/artistic)
46.	Rebeiz, A. G., et al. (author) Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials) 2005 In: Am J Cardiol. - 0002-9149. ; 95:5, s. 611-4 Journal article (peer-reviewed)abstract We compared combination fibrinolytic plus glycoprotein IIb/IIIa inhibitor therapy with stand-alone fibrinolysis with respect to speed and stability of reperfusion in patients who had acute ST-segment elevation myocardial infarction; data were obtained from 654 patients in 4 trials (Integrilin to Manage Platelet Aggregation to Combat Thrombosis in Acute Myocardial Infarction, Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction, Integrilin and Tenecteplase in Acute Myocardial Infarction, and the Fifth Global Use of Strategies to Open Occluded Coronary Arteries) that compared thrombolytics plus lamifiban, eptifibatide, or abciximab with standard thrombolysis. We found significantly faster and more stable ST-segment recovery with combination therapy starting at 60 minutes (56.7% vs 48.0% with >/=50% ST-segment resolution, p = 0.03) and sustained over 180 minutes after drug administration; this transient benefit may suggest a time frame when more optimal percutaneous coronary intervention can be performed.
47.	Sartorelli, P, et al. (author) How to improve skin notation. Position paper from a workshop 2007 In: Regulatory toxicology and pharmacology : RTP. - : Elsevier BV. - 0273-2300. ; 49:3, s. 301-307 Journal article (other academic/artistic)
48.	Sartorelli, P, et al. (author) The 2008 ICOH Workshop on Skin Notation 2010 In: La Medicina del lavoro. - 0025-7818. ; 101:1, s. 3-8 Journal article (other academic/artistic)
49.	Sjogren, B, et al. (author) An occupational exposure limit for welding fumes is urgently needed 2022 In: Scandinavian journal of work, environment & health. - : Scandinavian Journal of Work, Environment and Health. - 1795-990X .- 0355-3140. ; 48:1, s. 1-3 Journal article (other academic/artistic)
50.	Sjögren, B, et al. (author) An occupational exposure limit for welding fumes is urgently needed 2022 In: Scandinavian journal of work, environment & health. - 1795-990X .- 0355-3140. ; 48:1, s. 1-3 Journal article (other academic/artistic)

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