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1.	Azar, Christian, 1969, et al. (author) Inrätta ett miljöpolitiskt råd direkt under statsministern 2014 In: Dagens nyheter. - : AB Dagens nyheter. - 1101-2447. Journal article (pop. science, debate, etc.)
2.	Andrén, Mats, et al. (author) Att lära sig språk 2013 In: Språket, människan och världen : människans språk 1-2 - människans språk 1-2. - Lund : Studentlitteratur AB. - 9789144083391 ; , s. 73-89 Book chapter (pop. science, debate, etc.)
3.	Arnesson, Annika, et al. (author) Forskningsverksamhet och försöksstallar inom nöt- och lammköttsproduktion i Wales, Irland, Skottland och Danmark : erfarenhetsutbyte - 2009 2010 Reports (other academic/artistic)abstract SLU:s forskningsstation för nöt- och lammköttsproduktion är belägen på Götala gård utanför Skara. Här bedrivs utfodringsförsök till nöt och lamm baserat på vall och bete kompletterat med huvudsakligen inhemska kraftfodermedel, där syftet är att ta fram nöt- och lammkött av hög kvalitet. Djurens välfärd och lantbrukarens ekonomi står i centrum för vår forskning. Under 2010 kommer projektering utföras för nya försöksstallar för nöt och får. För att utbyta erfarenheter med forskare inom nöt- och lammproduktion och få idéer till smarta byggnadslösningar och utfodringsanläggningar i försöksstallar besökte vi under 2009 IBERS, Aberystwyth i Wales, Teagasc Grange Beef Research Centre på Irland och SAC Animal Breeding & Development Team i Skottland. I Danmark besökte vi Tjele gods, Forskningscenter Foulum och Kvaegbrugets Forsogscentrum (KFC). Forskningen i Wales, Irland och Skottland hade blivit mer inriktad mot mera tvärvetenskaplig forskning med klimat och miljö som viktiga faktorer. De nybyggda stallarna på IBERS och SAC var stora ljusa, luftiga fribärande hallar, där större delen av väggarna bestod av vindvävsgardiner. Man hade satsat på breda foderbord, flexibla boxstorlekar och fantastiska hanteringsanläggningar för sortering, vägning och behandling av djur. Det var imponerande att se deras foderhantering med många silor i olika storlekar och allt under tak. Fullfoder var vanligt och medförde en rationell utfodring. De datastyrda utfodringskrubborna, av både den holländska och brittiska modellen, krävde både tillsyn och skötsel för att fungera. Det blir också en stor mängd data att hantera vid användning av dem. På Tjele gods i Danmark hade man satsat på en enkel byggnad, med djurhantering i fokus. Mycket av arbetet gjordes maskinellt för att spara arbetskraft. Foderanläggningen på Foulum gav möjlighet till stor flexibilitet när det gäller att hantera många fodermedel och olika foderblandningar. Fodret utfodrades i de olika stallarna med hjälp av förarlösa robottruckar. Försöksstallet för mjölkkor var isolerat och inrett med liggbås och skrapade fodergångar. Här gavs möjlighet att genomföra försök med många behandlingar under exakt samma stallbetingelser. Stallet var utrustat med individuell utfodring av grovfoder. Kraftfoder fanns i automater där de kunde ha fyra olika foder samtidigt. Den dammsugare som användes för att tömma foderkrubborna ansågs helt nödvändig för en rationell foderhantering. All data från försöksstallarna registrerades automatiskt och samlades in till en gemensam databank, varifrån forskarna kunde hämta information. All datafiltrering sysselsatte fem datatekniker. Det som forskarna på Foulum skickade med oss som råd inför vår projektering, var att tänka på att ta till ordenligt när det gäller utrymmen, så att foder- och djurhantering blir rationell. KFC var en mycket välskött försöksgård som ägdes av näringen. Eftersom de höll på att slutföra en om- och tillbyggnation av ladugården var det extra intressant för oss att se och höra hur de tänkt vid projekteringen. De hade t.ex. gått ifrån gummimattor i mjölkkostallets fodergångar och satsat på betongspalt och gödselrobot, för att få torrare miljö och därmed bättre klövhälsa. Efter att ha prövat många olika sorter liggunderlag i liggbåsen hade man satsat på en 18 cm tjock madrass med små luftfyllda gummibollar, vilken höll formen bra. En självgående strövagn på räls för spån över liggbåsen, samt även en för halm i ungdjurs-avdelningen sparade mycket arbete. Även på KFC tillämpades individuell utfodring till alla mjölkkor och de hade 2-2,5 kor/ fodertråg. Utfodring gjordes fyra gånger per dag. I ungdjursstallet var det två fodertråg per tio djur och utfodringen gjordes två gånger per dag. Fodergrindar vid varje fodertråg var nödvändigt hos ungdjuren för att inte djuren skulle bli undanknuffade när de åt. Personalen påpekade att den individuella utfodringen kräver mycket datatekniskt arbete för att installation och funktion ska bli användarvänlig. Diskussionen med forskare och försökspersonal har varit oerhört värdefull och gett oss mycket att tänka på inför vår egen planering av nya försöksstallar. Det viktigaste att tänka på vid projektering, enligt våra kollegor både på Brittiska öarna och i Danmark, är flexibilitet, väl tilltagna ytor och en genomtänkt logistik. Det ger förutsättningar för stallar med god forsknings- och arbetsmiljö samt en god djurvälfärd
4.	Azar, Christian, et al. (author) Miljöpolitikens spelplan : Rapport från Miljöforskningsberedningen 2014 Reports (pop. science, debate, etc.)
5.	Azar, Christian, 1969, et al. (author) Miljöpolitikens Spelplan 2014 Reports (other academic/artistic)
6.	Bardel, Annika, 1952-, et al. (author) Age and sex related self-reported symptoms in a general population across 30 years: Patterns of reporting and secular trend 2019 In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 14:2 Journal article (peer-reviewed)abstract Objective :To study age and sex specific prevalence of 30 symptoms in random samples from the general population and to analyze possible secular trends across time. Study population: The study was based on data from eight on-going Swedish cohort studies, with baseline investigations performed between 1973 and 2003. Samples were drawn from the general population of the cities of Gothenburg and Eskilstuna, and of Uppsala County. Overall, 20,160 subjects were sampled, 14,470 (71.8%) responded, of whom 12.000 were unique subjects, and 2548 were part of more than one sample. Methods: The Complaint score sub-scale of the Gothenburg Quality of Life instrument, listing 30 general symptoms was used. Responders were asked to indicate which symptoms they had experienced during the last three months. Results: Women reported on average 7.8 symptoms, and men 5.3 (p<0.0001). Women reported higher prevalence than men for 24 of the 30 symptoms. In multivariate analyses four patterns of prevalence across age were identified in both men and women; increasing prevalence, decreasing, stable and biphasic prevalence. The symptoms in the various pattern groups differed somewhat between men and women. However, symptoms related to strain were prominent among symptoms decreasing with age. Moreover, there were secular trends. Across all symptoms reporting prevalence increased over time in men (p<0.001) as well as in women (p<0.0001). Conclusions: Women reported higher total symptom prevalence than men. Symptoms related to health generally increased with age, while symptoms related to stress decreased markedly. Significant secular trends across time regarding symptom prevalence were found. © 2019 Bardel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
7.	Bärnarp, Tora, et al. (author) Skönhet hållbarhet funktion 2023 Reports (other academic/artistic)abstract Denna publikation redovisar studenternas enskilda arbeten. Materialet har tillkommit inom ramen för läsårets tema ”Skönhet, hållbarhet och funktion”, men varje studie utgår ifrån studenternas egna val av ämne.
8.	Dewi, Nikmah Utami, et al. (author) Anthropometry and the risk of lung cancer in EPIC 2016 In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 184:2, s. 129-139 Journal article (peer-reviewed)abstract The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)2) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.
9.	Dotevall, Annika, 1957, et al. (author) Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18-year follow-up of the BEDA study 2004 In: Diabet Med. - 0742-3071. ; 21:6, s. 615-22 Journal article (peer-reviewed)abstract AIM: To investigate risk factors for the development of diabetes in middle-aged women. METHODS: A random population sample of 1351 women without prior diabetes or cardiovascular disease, aged 39-65 years, took part in a screening study in 1979-1981 with questionnaires, physical examination and blood sampling. Development of diabetes up to 1998 was identified at a second examination in 1997-1998. RESULTS: Seventy-three women (5.4%) were diagnosed with diabetes during follow-up. As expected, obesity resulted in a rising age-adjusted risk with hazards ratio 3.2 [95% confidence interval (CI) 1.3, 8.1] at body mass index (BMI) 24-27 kg/m(2), and 8.3 (3.5, 19.7), at BMI > or = 27, compared with BMI < 22 kg/m(2). S-triglycerides (TG) carried a steeply increasing age-adjusted risk with hazards ratio 4.0 (95% CI 2.1, 7.6) already at s-TG 1.0-1.4 mmol/l, 7.1 (3.6, 14.0) at s-TG 1.5-1.9 mmol/l and 9.3 (4.3, 20.2) at s-TG > or = 2.0 mmol/l compared with s-TG < 1.0 mmol/l. Increasing systolic blood pressure (SBP) to 130-144, 145-159 and > or = 160 mmHg escalated the hazards ratio of diabetes to 1.6 (0.8, 3.3), 3.6 (1.7, 7.4) and 5.6 (2.7, 11.4), respectively, compared with SBP < 130 mmHg. Also, low physical activity predicted diabetes, with hazards ratio 2.1 (1.3, 3.3) for sedentary compared with non-sedentary activity. Smoking was not associated with increased risk of diabetes. After adjustment for BMI, SBP and physical activity, increasing TG level remained a strong and significant risk factor for diabetes [hazards ratio 3.0 (1.6, 5.7), 3.7 (1.8, 7.7) and 4.5 (2.0, 10.0), P < 0.001]. CONCLUSIONS: Among middle-aged Swedish women even very slightly elevated s-TG resulted in a considerably enhanced risk of developing diabetes, which was independent of age, BMI, blood pressure and physical activity.
10.	Fanidi, Anouar, et al. (author) Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort 2016 In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6 Journal article (peer-reviewed)abstract Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, Ptrend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk of HNC, as well as improved survival following diagnosis.
11.	Fredén, Annika, et al. (author) Skäl att rösta strategiskt i riksdagsval 2015 In: Fragment: SOM-undersökningen 2014. - Göteborg : University of Gothenburg. - 0284-4788. - 9789189673328 ; 63, s. 377-386 Book chapter (peer-reviewed)
12.	Fricke, Katrin, et al. (author) Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome: 20 Years of National Data From Sweden 2022 In: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 11:7 Journal article (peer-reviewed)abstract BACKGROUND: Hypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation. METHODS AND RESULTS: This was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation between 1999 and 2018 in Sweden. Patients (n=167) were grouped based on the anatomic subtypes aortic-mitral atresia, aortic atresia-mitral stenosis (AA-MS), and aortic-mitral stenosis. The left ventricular phenotypes including globular left ventricle (Glob-LV), miniaturized and slit-like left ventricle (LV), and the incidence of major adverse events (MAEs) including mortality were assessed. The overall mortality and MAEs were 31% and 41%, respectively. AA-MS (35%) was associated with both mortality (all other subtypes versus AA-MS: interstage-I: hazard ratio [HR], 2.7; P=0.006; overall: HR, 2.2; P=0.005) and MAEs (HR, 2.4; P=0.0009). Glob-LV (57%), noticed in all patients with AA-MS, 61% of patients with aortic stenosis-mitral stenosis, and 19% of patients with aortic atresia-mitral atresia, was associated with both mortality (all other left ventricular phenotypes versus Glob-LV: interstage-I: HR, 4.5; P=0.004; overall: HR, 3.4; P=0.0007) and MAEs (HR, 2.7; P=0.0007). There was no difference in mortality and MAEs between patients with AA-MS and without AA-MS with Glob-LV (P>0.15). Patients with AA-MS (35%) or Glob-LV (38%) palliated with a Blalock-Taussig shunt had higher overall mortality compared with those palliated with Sano shunts, irrespective of the stage 1 palliation year (AA-MS: HR, 2.6; P=0.04; Glob-LV: HR, 2.1; P=0.03). CONCLUSIONS: Glob-LV and AA-MS are independent morphological risk factors for adverse short-and long-term outcome, especially if a Blalock-Taussig shunt is used as part of stage 1 palliation. These findings are important for the clinical management of patients with hypoplastic left heart syndrome.
13.	Fridell, Erik, 1963, et al. (author) Model studies of NOx storage and reduction of nitrogen oxides 1999 In: 4th European Congress on Catalysis (EUROPACAT-IV) in Rimini, Italy, September 5-10, 1999.. Conference paper (peer-reviewed)
14.	Gad, Helge, et al. (author) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool 2014 In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221 Journal article (peer-reviewed)abstract Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
15.	Guida, Florence, et al. (author) Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins 2018 In: JAMA Oncology. - : American Medical Association (AMA). - 2374-2437 .- 2374-2445. ; 4:10 Journal article (peer-reviewed)abstract Importance There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.Objective To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.Design, Setting, and Participants Prediagnostic samples from 108 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and samples from 216 smoking-matched controls from the Carotene and Retinol Efficacy Trial (CARET) cohort were used to develop a biomarker risk score based on 4 proteins (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cytokeratin-19 fragment [CYFRA 21-1], and the precursor form of surfactant protein B [Pro-SFTPB]). The biomarker score was subsequently validated blindly using absolute risk estimates among 63 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and 90 matched controls from 2 large European population-based cohorts, the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS).Main Outcomes and Measures Model validity in discriminating between future lung cancer cases and controls. Discrimination estimates were weighted to reflect the background populations of EPIC and NSHDS validation studies (area under the receiver-operating characteristics curve [AUC], sensitivity, and specificity).Results In the validation study of 63 ever-smoking patients with lung cancer and 90 matched controls (mean [SD] age, 57.7 [8.7] years; 68.6% men) from EPIC and NSHDS, an integrated risk prediction model that combined smoking exposure with the biomarker score yielded an AUC of 0.83 (95% CI, 0.76-0.90) compared with 0.73 (95% CI, 0.64-0.82) for a model based on smoking exposure alone (P = .003 for difference in AUC). At an overall specificity of 0.83, based on the US Preventive Services Task Force screening criteria, the sensitivity of the integrated risk prediction (biomarker) model was 0.63 compared with 0.43 for the smoking model. Conversely, at an overall sensitivity of 0.42, based on the US Preventive Services Task Force screening criteria, the integrated risk prediction model yielded a specificity of 0.95 compared with 0.86 for the smoking model.Conclusions and Relevance This study provided a proof of principle in showing that a panel of circulating protein biomarkers may improve lung cancer risk assessment and may be used to define eligibility for computed tomography screening.
16.	Halford, Christina, et al. (author) A population-based study of nearly 15 000 observations among Swedish women and men during 1973-2003 2012 In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 2:6 Journal article (peer-reviewed)abstract Objectives Global self-rated health (SRH) has become extensively used as an outcome measure in population health surveillance. The aim of this study was to analyse the effects of age and secular trend (year of investigation) on SRH.Design Prospective cohort study, using population-based data from eight ongoing cohort studies, with sampling performed between 1973 and 2003.Setting Sweden.Participants 11 880 women and men, aged 25–99 years, providing 14 470 observations.Primary outcome measure Global SRH.Results In multiple ordinal logistic regression analyses, adjusted for the effects of covariates, there were independent effects of age (p<0.0001) and of year of investigation (p<0.0001) on SRH. In women the association was linear, showing lower levels of SRH with increased age, and more recent year of investigation. In men the association was curvilinear, and thus more complex. The final model explained 76.2% of the SRH variance in women and 74.5% of the variance in men.Conclusions SRH was strongly and inversely associated with age in both sexes, after adjustment for other outcome-affecting variables. There was a strongly significant effect of year of investigation indicating a change in SRH, in women towards lower levels over calendar time, in men with fluctuations across time.
17.	Halford, Christina, et al. (author) Effects of self-rated health on sick-leave, disability-pension, hospital admissions and mortality : a population-based study of nearly 15,000 observations among Swedish women and men followed 1973-2003 Other publication (other academic/artistic)
18.	Halford, Christina, et al. (author) Effects of self-rated health on sick leave, disability pension, hospital admissions and mortality. A population-based longitudinal study of nearly 15,000 observations among Swedish women and men. 2012 In: BMC public health. - : Springer Science and Business Media LLC. - 1471-2458. ; 12 Journal article (peer-reviewed)abstract Simple global self-ratings of health (SRH) have become increasingly used in national and international public health monitoring, and in recent decades recommended as a standard part of health surveys. Monitoring developments in population health requires identification and use of health measures, valid in relation to targets for population health. The aim of the present study was to investigate associations between SRH and sick leave, disability pension, hospital admissions, and mortality, adjusted for effects of significant covariates, in a large population-based cohort. The analyses were based on screening data from eight population-based cohorts in southern and central Sweden, and on official register data regarding sick-leave, disability pension, hospital admissions, and death, with little or no data loss. Sampling was performed 1973-2003. The study population consisted of 11,880 women and men, age 25-99 years, providing 14,470 observations. Information on SRH, socio-demographic data, lifestyle variables and somatic and psychological symptoms were obtained from questionnaires. There was a significant negative association between SRH and sick leave (Beta -13.2, p<0.0001, and -9.5, p<0.01, in women and men, respectively), disability pension (Hazard ratio 0.77, p<0.0001 and 0.76, p<0.0001, in women and men, respectively), and mortality, adjusted for covariates. SRH was also significantly associated with hospital admissions in men (Hazard ratio 0.87, p<0.0001), but not in women (Hazard ratio 0.96, p0.20). Associations between SRH on the one hand, and sick leave, disability pension, hospital admission, and mortality, on the other, were robust during the follow-up period. SRH had strong predictive validity in relation to use of social insurance facilities and health care services, and to mortality. Associations were strong and robust during follow-up.
19.	Härensatm, Annika, et al. (author) Beskrivning och utvärdering av variabler om arbets- och livsvillkor : resultat av analyser med variabelansats samt kvalitativ och kvantitativ enkätfrågeprövning 1999 Reports (other academic/artistic)
20.	Härenstam, Annika, et al. (author) Urvalsstrategier, studiegruppen och forskningsprocessen 1999 Reports (other academic/artistic)
21.	Härenstam, Annika, et al. (author) Vad kännetecknar och innebär moderna arbets- och livsvillkor? : resultat av analyser med personansats samt utveckling av analysmodeller för befolkningsstudier 1999 Reports (other academic/artistic)
22.	Ivarsson, Anneli, et al. (author) Healing the health system after civil unrest 2015 In: Global Health Action. - : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 8:1, s. 1-4 Journal article (peer-reviewed)
23.	Johansson, Henrik J., et al. (author) Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin 2018 In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8 Journal article (peer-reviewed)abstract Malassezia sympodialis is a dominant commensal fungi in the human skin mycobiome but is also associated with common skin disorders including atopic eczema (AE). M. sympodialis releases extracellular vesicles, designated MalaEx, which are carriers of small RNAs and allergens, and they can induce inflammatory cytokine responses. Here we explored how MalaEx are involved in hostmicrobe interactions by comparing protein content of MalaEx with that of the parental yeast cells, and by investigating interactions of MalaEx with cells in the skin. Cryo-electron tomography revealed a heterogeneous population of MalaEx. iTRAQ based quantitative proteomics identified in total 2439 proteins in all replicates of which 110 were enriched in MalaEx compared to the yeast cells. Among the MalaEx enriched proteins were two of the M. sympodialis allergens, Mala s 1 and s 7. Functional experiments indicated an active binding and internalization of MalaEx into human keratinocytes and monocytes, and MalaEx were found in close proximity of the nuclei using super-resolution fluorescence 3D-SIM imaging. Our results provides new insights into host-microbe interactions, supporting that MalaEx may have a role in the sensitization and maintenance of inflammation in AE by containing enriched amounts of allergens and with their ability to interact with skin cells.
24.	Johansson, Victoria, et al. (author) Språk och hjärna 2013 In: Språket, människan och världen : människans språk 1-2. - 9789144083391 ; , s. 225-241 Book chapter (pop. science, debate, etc.)
25.	Johansson, Victoria, et al. (author) Språk och hjärna 2013 In: Språket, människan och världen. - Lund : Studentlitteratur AB. Book chapter (other academic/artistic)
26.	Klingberg-Allvin, Marie, et al. (author) One foot wet and one foot dry : transition into motherhood among married adolescent women in rural Vietnam 2008 In: Journal of Transcultural Nursing. - : Sage Publications. - 1043-6596 .- 1552-7832. ; 19:4, s. 338-346 Journal article (peer-reviewed)abstract This study explores married Vietnamese adolescents' perceptions and experiences related to transition into motherhood and their encounter with health care service. In-depth interviews were conducted with 22 women younger than 20 who were either pregnant or had newly delivered. It emerged from the narratives that young women experienced ambivalence in the transition to motherhood in that they felt too young but also happy to be able to please their husband and the extended family. Patterns were shown indicating that the participants experienced lacking power with regard to decisions in relation to pregnancy, delivery, and contraceptive usage. Feelings of being patronized and ignored in the encounter with health care providers were seen in the narratives. Findings might be used for reproductive health care providers, social workers, and educators in their contact with young mothers to empower them to make their own decisions with regard to marriage, childbearing, and contraception.
27.	Krupanek, Janusz, et al. (author) Sectoral Guidance for Chemicals Management in the Surface treatment of metals and plastics Industry : HAZBREF-project Activity 4.1 report 2021 Reports (other academic/artistic)abstract BackgroundThe main instrument on EU level to control industrial releases is the Industrial Emissions Directive (IED), particularly through the publication of BAT reference documents (BREFs) and related BAT Conclusions, which is the reference for setting the permit conditions throughout EU for IED installations. However, the BREFs published so far do not contain adequate information on specific hazardous chemicals used and released from industry which makes the control difficult for the industry and the permitting and supervising authorities.One of the case sectors in the HAZBREF project is the surface treatment of metals and plastics (STM). This sector was chosen due to the use of chemicals, potential emissions, the wide range of products as well as technological processes and the upcoming STM BREF review. The other HAZBREF case sectors are textile industry and chemical industry which are addressed in separate reports.The lack of knowledge on the use and flow of specific hazardous chemicals in the industrial processes makes chemical control and reduction measures difficult. The problem is that often neither plant operators nor authorities know which substances are relevant to be treated and which handling measures are needed. Surface treatment of metals and plastics is covered by the STM BREF document, published in 2006. According to the last work programme of the EIPPCB the review of the EU STM BREF is planned to start in 2021.Purpose of the documentThis sectoral guidance contains information on uses of hazardous chemicals, the best practices in chemical management and recommendations on enhancing the permitting process in the STM sector. This document sums up the findings from HAZBREF project and is based on industrial case studies, interviews with authorities and expert judgment. The aim is to describe good practices in chemical management to be utilized by STM installations as well as environmental and chemical authorities. These include technical, organisational and management aspects and concrete tools supporting chemical management.The report addresses the STM sector as a whole in Europe, although the main part of the findings is generated from HAZBREF case installation and other experiences in the Baltic Sea Region. The document provides also general descriptions of BAT proposals related to management of hazardous chemicals and substances. These findings of the guidance will feed into in the forthcoming revision of the STM BREF. They are also to be used for HELCOM recommendations on how to reduce the discharge of hazardous substances into the Baltic Sea.Moreover, the document provides an overview of applicable legal requirements, procedures and other obligations of installation operators regarding use of chemicals and releases of hazardous substances. This includes guidance for tools to identify and assess relevant hazardous substances used and released from the STM installations.Main findings and proposalsImprovement of chemical management systemA Chemical Management System provides a systematic way of managing chemicals through the whole process on the site. Most of the companies have implemented quality management standards such as ISO 9000, ISO 14000, EMAS and integrated EHS programs which also address certain aspects of chemical management. The quality of chemical management systems in the companies differs depending on the scale of operation, ownership and awareness. Integration of good practices of chemical management within already implemented management systems strengthens the ability to reduce environmental risks. HAZBREF project strongly recommends the establishment and regular use of a chemical management system at IED installations.Development of a chemical inventoryThe establishment and maintenance of a chemical inventory is an importantprerequisite for effective and responsible chemicals management in the STMsector. All chemicals and raw materials along with information on their propertiesused in all processes and activities at the site should be listed in a database. Such adatabase is a key part of chemical management allowing for systematic riskassessment, management of chemicals flows and their storage. The information in the chemical list/database must be searchable and should be updated regularly. Most of the information needed is available in the safety datasheets (SDS). If some information is missing from the SDS, the supplier should be asked to provide this. Good routines to handle new and updated SDSs are crucial to have an up to date and reliable chemical database. These routines should involve on-site handling and updates as well as communication with suppliers on how SDSs are delivered. Well-managed chemical inventories can significantly simplify the environmental permit application process both for the operators and the permitting authorities.Better use of Chemical Management Tools and training of stafNumerous references and tools are available to support STM companies and competent authorities in implementing the good chemical management required in the IED. HAZBREF recommends that operators use proper tools for risk assessment and evaluation of the efficiency of chemical management.Use and improvement of risk assessment tools such as extended SDS and material flow analysis should be promoted among installation operators in this respect. The HAZBREF project has developed a comprehensive tool that helps the operators to identify the site-specific hazardous substances that should be considered in strategic and operational decisions.Awareness raising and training of staff in the use of chemical management tools and systems is crucial for implementation of good chemical management practices at the installations.SubstitutionA regular check aiming at identifying potentially new available and safer alternatives to the hazardous chemicals used is an important measure to minimise chemical risks at the installation. A successful substitution work can be performed in four stages: - Identification of hazardous substances - Screening for possible alternatives - Evaluation and choice of alternatives and Development of new alternatives.Substitution can be aimed for any hazardous chemical used at installation level where it is needed in order to protect environment or human health. However, regrettable substitution (i.e. move to use new chemical that is equally or more hazardous than the substituted chemical or results in cross-media effects) must be avoided.Assessment and improvement of SDSEfficient chemicals management requires high quality of the Safety Data Sheets (SDS). The SDS should sufficiently describe the chemical properties and include information about exposure (including use and emissions), eco-toxicology and proper storage and handling. A SDS must also contain information on whether the chemical product contains substances on the SVHC list, priority substances under the Water Framework Directive WFD and the POPs convention. In case a chemical supplier fails to provide a SDS of sufficient quality, it is the duty of both the operator and the competent authority to demand the missing information. This is already required by law in some countries, e.g. Germany. It is also important that the operators know how to extract and consolidate the relevant information from the SDS to their permit applications and verify the quality of different information sources.The development of an extended SDS including exposure scenarios and improved data on environmental effects would facilitate better risk assessment of individual chemicals used in specific processes. This would lead to more efficient monitoring and help focusing on substances of concern. Improved SDSs for raw materials with information on impurities or additives would facilitate more complete chemical inventories.Continuous improvement of BAT implementation The implementation of BAT needs to be continuously monitored and improved at the installation considering site specific technological, economical and environmental aspects. The findings from Polish HAZBREF case studies is that fulfilment of BAT requirements can be challenging if all improvements need to be done in a short time period. For example, closed-loop systems are considered necessary additional process-integrated techniques that it is important to implementstep by step in the installations.Circular economyThe STM sector is a significant user of non-renewable resources (metals), and recycling of recovered metal containing materials such as metal substrates orelectrolytes back to the process is good practice. Such recovery processes are widely used for basic metals, such as zinc, copper and nickel, which are used as valuable secondary raw materials SRM. High costs of recovery processes and high energy consumption as well as the variety of chemicals and metals used in STM processes often hinders recycling. In cases where recycling is not feasible, pretreatment of contaminated waste water on site and subsequent off-site treatment of generated metal containing sludges is standard practice.Permitting processBeside best practices in chemical management, the project also elaborated recommendations on enhancing the permitting process in the STM sector. It can be concluded that the existing general structure and content of the permit application procedures are as such sufficient to deal with hazardous substances and chemicals. Nevertheless, in practice the permit process could be improved with more communication between the applicant and the permitting authority during the application phase. More co-operation between chemical, environmental and occupational health authorities is suggested to achieve a smooth information flow and reduce double work regarding requirements under different legislations concerning chemicals and hazardous substances. In some countries, for example in Finland, the supervising practices in different parts of a given country need harmonising s
28.	Lagerkvist, Anna-Lena, 1956, et al. (author) Obstetric brachial plexus palsy: a prospective, population-based study of incidence, recovery, and residual impairment at 18 months of age. 2010 In: Dev Med Child Neurol. - : Wiley. - 1469-8749 .- 0012-1622. ; 52:6, s. 529-34 Journal article (peer-reviewed)abstract Aim The aim of this investigation was to study the incidence of obstetric brachial plexus palsy (OBPP), to prospectively follow the recovery process, to assess the functional outcome at 18 months of age, and to find early prognostic indicators. Method Of the 38 749 children born between 1999 and 2001 in western Sweden, 114 (70 males, 44 females) had an OBPP. Ninety-eight children were examined on six occasions at up to 18 months of age. Muscle strength, range of motion, hand preference, and functional abilities were noted, and the severity of the OBPP was classified. Results The incidence of OBPP was 2.9 per 1000 live births, and the incidence of persisting OBPP was 0.46 per 1000. At 3 months of age, the predictive value of regained elbow flexion for complete recovery was 100%, 99% of shoulder external rotation, and 96% of forearm supination. Most of the 18 children with persisting OBPP could perform functional activities but asymmetries were noted. Five children had a mild, 11 had a moderate, and two had a severe impairment. Three had undergone nerve surgery, one with a mild and two with a severe persisting impairment. Interpretation Most children with an OBPP recover completely. Muscle strength at 3 months of age can be used to predict outcome.
29.	Landin-Wilhelmsen, Kerstin, 1952, et al. (author) Calcaneal ultrasound measurements are determined by age and physical activity. Studies in two Swedish random population samples. 2000 In: Journal of internal medicine. - 0954-6820. ; 247:2, s. 269-78 Journal article (peer-reviewed)abstract AIM: To present reference values and correlations with body composition, blood variables and lifestyle factors. SUBJECTS: Two random population samples from Göteborg, Sweden, one comprising 184 men and 455 women aged 25-64 years (MONICA) and the other 860 women aged 55-82 years (BEDA) were studied. METHODS: Calcaneal ultrasound measurement (LUNAR Achilles) and bioimpedance were measured. Smoking habits, coffee consumption, physical activity, psychological stress, education and marital status, as well as blood lipids, blood pressure, and fractures were studied. RESULTS: Broadband ultrasound attenuation and stiffness were higher in men than in women (P < 0. 001), but speed of sound did not differ between sexes. Speed of sound, broadband ultrasound attenuation and stiffness decreased with age (P < 0.001). In both sexes speed of sound, broadband ultrasound attenuation and stiffness correlated positively to body size variables, and negatively with smoking in women after adjustment for age. Speed of sound, broadband ultrasound attenuation and stiffness were positively related to physical activity in both sexes, and these relationships were the only ones that remained in multivariate analyses in addition to age (negative). Osteoporotic fractures increased with age. Speed of sound, broadband ultrasound attenuation and stiffness were lower amongst women with osteoporotic fractures. CONCLUSION: Speed of sound, broadband ultrasound attenuation and stiffness decreased with age and increased with physical activity, but body weight and height were not correlated in multivariate analyses. Osteoporotic fractures increased with age and were associated with lower calcaneal ultrasound values.
30.	Moberg, Christina, et al. (author) De unga gör helt rätt när de stämmer staten 2022 In: Aftonbladet. - 1103-9000. Journal article (pop. science, debate, etc.)abstract 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
31.	Mollberg, Margareta, 1953, et al. (author) Comparison in obstetric management on infants with transient and persistent obstetric brachial plexus palsy. 2008 In: Journal of child neurology. - : SAGE Publications. - 1708-8283 .- 0883-0738. ; 23:12, s. 1424-32 Journal article (peer-reviewed)abstract The outcome of obstetric brachial plexus palsy depends on the severity of the lesion of the nerve fibers. The aim of the prospective study is to evaluate if differences in force used in downward traction on the fetal head correlate to the number of nerve roots affected. At final neurological examination at 18 months of age, complete neurological recovery occurred in 80 of 98 children (82%). Downward traction of the fetal head was applied more often and with greater force in the group with persistent damage. There was a significant correlation between the force used to the number of nerve roots affected. The risk of persistent obstetric brachial plexus palsy at age 18 months depended on obstetric management and increased significantly with increasing force used in downward traction of the fetal head.
32.	Mårald, Erland, 1970-, et al. (author) Forest governance and management across time : developing a new forest social contract 2017 Book (peer-reviewed)abstract The influence of the past, and of the future on current-time tradeoffs in the forest arena are particularly relevant given the long-term successions in forest landscapes and the hundred years' rotations in forestry. Historically established path dependencies and conflicts determine our present situation and delimit what is possible to achieve. Similarly, future trends and desires have a large influence on decision making. Nevertheless, decisions about forest governance and management are always made in the present – in the present-time appraisal of the developed situation, future alternatives and in negotiation between different perspectives, interests, and actors.This book explores historic and future outlooks as well as current tradeoffs and methods in forest governance and management. It emphasizes the generality and complexity with empirical data from Sweden and internationally. It first investigates, from a historical perspective, how previous forest policies and discourses have influenced current forest governance and management. Second, it considers methods to explore alternative forest futures and how the results from such investigations may influence the present. Third, it examines current methods of balancing tradeoffs in decision-making among ecosystem services. Based on the findings the authors develop an integrated approach – Reflexive Forestry – to support exchange of knowledge and understandings to enable capacity building and the establishment of common ground. Such societal agreements, or what the authors elaborate as forest social contracts, are sets of relational commitment between involved actors that may generate mutual action and a common directionality to meet contemporary challenges.
33.	Pascual, Didac, et al. (author) The missing pieces for better future predictions in subarctic ecosystems: A Torneträsk case study 2021 In: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 50:2, s. 375-392 Research review (peer-reviewed)abstract Arctic and subarctic ecosystems are experiencing substantial changes in hydrology, vegetation, permafrost conditions, and carbon cycling, in response to climatic change and other anthropogenic drivers, and these changes are likely to continue over this century. The total magnitude of these changes results from multiple interactions among these drivers. Field measurements can address the overall responses to different changing drivers, but are less capable of quantifying the interactions among them. Currently, a comprehensive assessment of the drivers of ecosystem changes, and the magnitude of their direct and indirect impacts on subarctic ecosystems, is missing. The Torneträsk area, in the Swedish subarctic, has an unrivalled history of environmental observation over 100 years, and is one of the most studied sites in the Arctic. In this study, we summarize and rank the drivers of ecosystem change in the Torneträsk area, and propose research priorities identified, by expert assessment, to improve predictions of ecosystem changes. The research priorities identified include understanding impacts on ecosystems brought on by altered frequency and intensity of winter warming events, evapotranspiration rates, rainfall, duration of snow cover and lake-ice, changed soil moisture, and droughts. This case study can help us understand the ongoing ecosystem changes occurring in the Torneträsk area, and contribute to improve predictions of future ecosystem changes at a larger scale. This understanding will provide the basis for the future mitigation and adaptation plans needed in a changing climate.
34.	Paulrud, Susanne, et al. (author) Användningsmönster och emissioner från vedeldade lokaleldstäder i Sverige 2006 Reports (other academic/artistic)abstract Syftet med projektet var att förbättra underlaget för framtida beräkningar av årliga emissioner från småskalig vedeldning i villor genom att dels mäta emissioner hemma hos dem som eldar med ved i braskaminer och spisinsatser, dels genom en enkätstudie undersöka hur ofta och på vilket sätt lokaleldstäder (kaminer, spisinsatser, öppen spis etc) eldas i Sverige. Procentuellt för alla regioner var fördelningen mellan olika slags lokaleldstäder: 44 % braskaminer, 23 % öppen spis, 23 % öppen spis med insats ,14 % värmeackumulerade ugnar och 12 % köksspisar (Summan av procenten blir inte 100 % eftersom en del fastigheter har flera olika typer av eldstäder) Mer än hälften av alla lokaleldstäderna var installerade före 1991. Uppmätta emissioner visade liten skillnad mellan kaminer och spisinsatser. Spisinsatserna hade något högre medelvärde för OGC, metan, NMVOC och stoft. Lägst emissioner hade de nya kaminerna och spisinsatserna med undantag av två fall. Emissionsdata varierade mellan 750-4700 mg/MJ för CO, 50-440 mg/MJ för OGC, 11-230 mg/MJ för metan, 20-260 mg/MJ för NMVOC, 0,5-17 mg/MJ för PAH och 20-180 mg/MJ för stoft.
35.	Rosengren, Annika, 1951, et al. (author) Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study 2004 In: J Intern Med. - 0954-6820. ; 255:1, s. 89-95 Journal article (peer-reviewed)abstract OBJECTIVES: To examine the long-term incidence of diabetes in relation to coffee consumption in Swedish women. DESIGN: Prospective longitudinal cohort study. SETTING: City of Goteborg, Sweden. SUBJECTS: A random population sample of 1361 women, aged 39-65 years, without prior diabetes or cardiovascular disease took part in a screening study in 1979-1981 with questionnaires, physical examination and blood sampling. MAIN OUTCOME MEASURES: The development of diabetes until 1999 was identified by questionnaires in a second screening and the Swedish hospital discharge register. RESULTS: Altogether, there were 74 new cases of diabetes. The risk of developing diabetes was 475 per 100 000 person-years in women who consumed two cups of coffee or less per day, 271 in women who consumed three to four cups per day, 202 with a consumption of five to six cups per day, and 267 in drinkers of seven cups or more per day. Associated hazard ratios, after adjustment for age, smoking, low physical activity, education and body mass index were 0.55 (0.32-0.95), 0.39 (0.20-0.77) and 0.48 (0.22-1.06) for daily consumption of three to four, five to six and seven cups or more, respectively, with a consumption of less than two per day as reference. Additional adjustment for serum cholesterol and triglycerides attenuated the relation between coffee and diabetes slightly, indicating a possible mediating effect on the effect of coffee by serum lipids. CONCLUSIONS: The findings of the present study support the hypothesis that coffee consumption protects from the development of diabetes in women.
36.	Ward, Heather A., et al. (author) Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition 2017 In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - : AMER ASSOC CANCER RESEARCH. - 1538-7755 .- 1055-9965. ; 26:6, s. 895-904 Journal article (peer-reviewed)abstract BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.RESULTS: Among men, a BMI < 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65).CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated.IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.
37.	Welin, Lennart, et al. (author) Prevalence of cardiovascular risk factors and the metabolic syndrome in middle-aged men and women in Gothenburg, Sweden 2008 In: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 8, s. 403- Journal article (peer-reviewed)abstract BACKGROUND Random samples of 50-year-old men living in Gothenburg have been examined every 10th year since 1963 with a focus on cardiovascular risk factors. The aims of the study were to acquire up-to-date information about risk factors in the fifth cohort of 50-year-old men and women, to re-examine those who were 50 years of age in 1993, and to analyse the prevalence of the metabolic syndrome (MetSyn) using different definitions. METHODS A random sample of men and women born in 1953 were examined in 2003-2004 for cardiovascular risk factors. Men born in 1943 and that participated in the examination in 1993 were also invited. Descriptive statistics were calculated. RESULTS The participation rate among men and women born in 1953 was 60 and 67% respectively. Among men born in 1943, the participation rate was 87%. The prevalence of obesity was from 15 to 17% (body mass index, BMI >or= 30) in the three samples. The prevalence of known diabetes was 4% among the 50-year-old men and 6% among the 60-year-old men, and 2% among the women. Increased fasting plasma glucose varied substantially from 4 to 33% depending on cut-off level and gender. Mean cholesterol was 5.4 to 5.5 mmol/l. Smoking was more common among women aged 50 (26%) than among men aged 50 (22%) and 60 years (15%). The prevalence of the MetSyn varied with the definition used: from 10 to 15.8% among the women, from 16.1 to 26% among 50-year-old men, and from 19.9 to 35% among the 60-year-old men. Only 5% of the men and women had no risk factors. CONCLUSION This study provides up-to-date information about the prevalence of cardiovascular risk factors and the MetSyn in middle-aged Swedish men and women. Different definitions of the MetSyn create confusion regarding which definition to use.
38.	Abrahamsson, L., et al. (author) Behöver arbetslinjen inte forskning? 2007 In: Svenska Dagbladet Brännpunkt (debattinlägg). ; :2007-11-28 Journal article (other academic/artistic)
39.	Abreu, Ilka, et al. (author) A metabolite roadmap of the wood-forming tissue in Populus tremula 2020 In: New Phytologist. - : John Wiley & Sons. - 0028-646X .- 1469-8137. ; 228:5, s. 1559-1572 Journal article (peer-reviewed)abstract Wood, or secondary xylem, is the product of xylogenesis, a developmental process that begins with the proliferation of cambial derivatives and ends with mature xylem fibers and vessels with lignified secondary cell walls. Fully mature xylem has undergone a series of cellular processes, including cell division, cell expansion, secondary wall formation, lignification and programmed cell death. A complex network of interactions between transcriptional regulators and signal transduction pathways controls wood formation. However, the role of metabolites during this developmental process has not been comprehensively characterized. To evaluate the role of metabolites during wood formation, we performed a high spatial resolution metabolomics study of the wood-forming zone of Populus tremula, including laser dissected aspen ray and fiber cells. We show that metabolites show specific patterns within the wood-forming zone, following the differentiation process from cell division to cell death. The data from profiled laser dissected aspen ray and fiber cells suggests that these two cell types host distinctly different metabolic processes. Furthermore, by integrating previously published transcriptomic and proteomic profiles generated from the same trees, we provide an integrative picture of molecular processes, for example, deamination of phenylalanine during lignification is of critical importance for nitrogen metabolism during wood formation.
40.	Abugabbara, Marwan, et al. (author) How to develop fifth-generation district heating and cooling in Sweden? : Application review and best practices proposed by middle agents 2023 In: Energy Reports. - : Elsevier Ltd. - 2352-4847. ; 9, s. 4971-4983 Journal article (peer-reviewed)abstract Sweden has an ambitious plan to fully decarbonise district heating by 2030 and to contribute with negative emissions of greenhouse gases in 2050. The vagaries of the energy market associated with climate, political, and social changes entail cross-sectoral integration that can fulfill these national targets. Fifth-generation district heating and cooling (5GDHC) is a relatively new concept of district energy systems that features a simultaneous supply of heating and cooling using power-to-heat technologies. This paper presents best practices for developing 5GDHC systems in Sweden to reach a consensus view on these systems among all stakeholders. A mixed-method combining best practice and roadmapping workshops has been used to disseminate mixed knowledge and experience from middle agents representing industry professionals and practitioners. Four successful implementations of 5GDHC systems are demonstrated and the important learned lessons are shared. The best practices are outlined for system planning, system modeling and simulation, prevailing business models for energy communities, and system monitoring. A roadmap from the middle agents’ point of view is composed and can be utilised to establish industry standards and common regulatory frameworks. © 2023 The Author(s)
41.	Achterberg, A., et al. (author) Detection of atmospheric muon neutrinos with the IceCube 9-string detector 2007 In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 76:2, s. 027101- Journal article (peer-reviewed)abstract The IceCube neutrino detector is a cubic kilometer TeV to PeV neutrino detector under construction at the geographic South Pole. The dominant population of neutrinos detected in IceCube is due to meson decay in cosmic-ray air showers. These atmospheric neutrinos are relatively well understood and serve as a calibration and verification tool for the new detector. In 2006, the detector was approximately 10% completed, and we report on data acquired from the detector in this configuration. We observe an atmospheric neutrino signal consistent with expectations, demonstrating that the IceCube detector is capable of identifying neutrino events. In the first 137.4 days of live time, 234 neutrino candidates were selected with an expectation of 211 +/- 76.1(syst)+/- 14.5(stat) events from atmospheric neutrinos.
42.	Achterberg, A., et al. (author) Five years of searches for point sources of astrophysical neutrinos with the AMANDA-II neutrino telescope 2007 In: Physical Review D. Particles, fields, gravitation, and cosmology. - 1550-7998. ; 75:10, s. 102001- Journal article (peer-reviewed)abstract We report the results of a five-year survey of the northern sky to search for point sources of high energy neutrinos. The search was performed on the data collected with the AMANDA-II neutrino telescope in the years 2000 to 2004, with a live time of 1001 days. The sample of selected events consists of 4282 upward going muon tracks with high reconstruction quality and an energy larger than about 100 GeV. We found no indication of point sources of neutrinos and set 90% confidence level flux upper limits for an all-sky search and also for a catalog of 32 selected sources. For the all-sky search, our average (over declination and right ascension) experimentally observed upper limit Phi0=((E/(1 TeV)))gamma·((d Phi)/dE) to a point source flux of muon and tau neutrino (detected as muons arising from taus) is Phinu[sub mu] + [overline nu ][sub mu]0+Phinu[sub tau] + [overline nu ][sub tau]0=11.1× 10-11 TeV-1 cm-2 s-1, in the energy range between 1.6 TeV and 2.5 PeV for a flavor ratio Phinu[sub mu] + [overline nu ][sub mu]0/Phinu[sub tau] + [overline nu ][sub tau]0=1 and assuming a spectral index gamma=2. It should be noticed that this is the first time we set upper limits to the flux of muon and tau neutrinos. In previous papers we provided muon neutrino upper limits only neglecting the sensitivity to a signal from tau neutrinos, which improves the limits by 10% to 16%. The value of the average upper limit presented in this work corresponds to twice the limit on the muon neutrino flux Phinu[sub mu] + [overline nu ][sub mu]0=5.5×10-11 TeV-1 cm-2 s-1. A stacking analysis for preselected active galactic nuclei and a search based on the angular separation of the events were also performed. We report the most stringent flux upper limits to date, including the results of a detailed assessment of systematic uncertainties.
43.	Achterberg, A., et al. (author) Multiyear search for a diffuse flux of muon neutrinos with AMANDA-II 2007 In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 76:4, s. 042008- Journal article (peer-reviewed)abstract A search for TeV-PeV muon neutrinos from unresolved sources was performed on AMANDA-II data collected between 2000 and 2003 with an equivalent live time of 807 days. This diffuse analysis sought to find an extraterrestrial neutrino flux from sources with nonthermal components. The signal is expected to have a harder spectrum than the atmospheric muon and neutrino backgrounds. Since no excess of events was seen in the data over the expected background, an upper limit of E-2 Phi(90%C.L.)< 7.4x10(-8) GeV cm(-2) s(-1) sr(-1) is placed on the diffuse flux of muon neutrinos with a Phi proportional to E-2 spectrum in the energy range 16 TeV to 2.5 PeV. This is currently the most sensitive Phi proportional to E-2 diffuse astrophysical neutrino limit. We also set upper limits for astrophysical and prompt neutrino models, all of which have spectra different from Phi proportional to E-2.
44.	Adman, Per, et al. (author) 171 forskare: ”Vi vuxna bör också klimatprotestera” 2019 In: Dagens nyheter (DN debatt). - Stockholm. - 1101-2447. Journal article (pop. science, debate, etc.)abstract DN DEBATT 26/9. Vuxna bör följa uppmaningen från ungdomarna i Fridays for future-rörelsen och protestera eftersom det politiska ledarskapet är otillräckligt. Omfattande och långvariga påtryckningar från hela samhället behövs för att få de politiskt ansvariga att utöva det ledarskap som klimatkrisen kräver, skriver 171 forskare i samhällsvetenskap och humaniora.
45.	Ahlborg, Gunnar, 1948, et al. (author) [New health insurance rules no obstacles for good prognosis in fatigue syndrome]. : Nya regler i sjukförsakringen inget hinder för god prognos vid utmattningssyndrom. 2010 In: Läkartidningen. - 0023-7205. ; 107:29-31, s. 1789-90 Journal article (other academic/artistic)
46.	Ahonen, Pasi, et al. (author) Writing resistance together 2020 In: Gender, Work and Organization. - : John Wiley & Sons. - 0968-6673 .- 1468-0432. ; 27:4, s. 447-470 Journal article (peer-reviewed)abstract This piece of writing is a joint initiative by the participants in the Gender, Work and Organization writing workshop organized in Helsinki, Finland, in June 2019. This is a particular form of writing differently. We engage in collective writing and embody what it means to write resistance to established academic practices and conventions together. This is a form of emancipatory initiative where we care for each other as writers and as human beings. There are many author voices and we aim to keep the text open and dialogical. As such, this piece of writing is about suppressed thoughts and feelings that our collective picket line allows us to express. In order to maintain the open-ended nature of the text, and perhaps also to retain some 'dirtiness' that is essential to writing, the article has not been language checked throughout by a native speaker of English.
47.	Al-Amin, Rasel A., Researcher, 1983-, et al. (author) Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ 2022 In: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 50:22, s. e129-e129 Journal article (peer-reviewed)abstract Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is therefore critical for guiding compound optimization in drug discovery, and for probing resistance mechanisms to targeted therapies in clinical samples. We describe a target engagement-mediated amplification (TEMA) technology, where oligonucleotide-conjugated drugs are used to visualize and measure target engagement in situ, amplified via rolling-circle replication of circularized oligonucleotide probes. We illustrate the TEMA technique using dasatinib and gefitinib, two kinase inhibitors with distinct selectivity profiles. In vitro binding by the dasatinib probe to arrays of displayed proteins accurately reproduced known selectivity profiles, while their differential binding to fixed adherent cells agreed with expectations from expression profiles of the cells. We also introduce a proximity ligation variant of TEMA to selectively investigate binding to specific target proteins of interest. This form of the assay serves to improve resolution of binding to on- and off-target proteins. In conclusion, TEMA has the potential to aid in drug development and clinical routine by conferring valuable insights in drug–target interactions at spatial resolution in protein arrays, cells and in tissues.
48.	Alenius Dahlqvist, Jenny, et al. (author) Heart rate variability in children with fontan circulation : lateral tunnel and extracardiac conduit 2012 In: Pediatric Cardiology. - New York : Springer-Verlag New York. - 0172-0643 .- 1432-1971. ; 33:2, s. 307-315 Journal article (peer-reviewed)abstract The technique in Fontan surgery has developed from the lateral tunnel (LT) toward the extracardiac conduit (EC) used to reduce long-term complications such as atrial arrhythmia and sinus node dysfunction. Heart rate variability (HRV) examines cardiac nervous activity controlling the sinus node. This study aimed to investigate HRV in a cohort of children with univentricular hearts, focusing on the relation between HRV and surgical procedure. For 112 children with Fontan circulation, HRV was analyzed using power spectral analysis. Spectral power was determined in three regions: very-low-frequency (VLF), low-frequency (LF), and high-frequency (HF) regions. Patients were compared with 66 healthy controls subject. Patients with LT were compared with patients who had EC. The children with Fontan circulation showed a significantly reduced HRV including total power (P < 0.0001), VLF (P < 0.0001), LF (P < 0.0001), and HF (P = 0.001) compared with the control subjects. The LT and EC patients did not differ significantly. Reduced HRV was found in both the LT and EC patients. In terms of HRV reduction, EC was not superior to LT.
49.	Alenius Dahlqvist, Jenny, 1972-, et al. (author) Pacemaker treatment after Fontan surgery-A Swedish national study 2019 In: Congenital Heart Disease. - : Computers, Materials and Continua (Tech Science Press). - 1747-079X .- 1747-0803. ; 14:4, s. 582-589 Journal article (peer-reviewed)abstract ObjectiveFontan surgery is performed in children with univentricular heart defects. Previous data regarding permanent pacemaker implantation frequency and indications in Fontan patients are limited and conflicting. We examined the prevalence of and risk factors for pacemaker treatment in a consecutive national cohort of patients after Fontan surgery in Sweden. MethodsWe retrospectively reviewed all Swedish patients who underwent Fontan surgery from 1982 to 2017 (n=599). ResultsAfter a mean follow-up of 12.2years, 13% (78/599) of the patients with Fontan circulation had received pacemakers. Patients operated with the extracardiac conduit (EC) type of total cavopulmonary connection had a significantly lower prevalence of pacemaker implantation (6%) than patients with lateral tunnel (LT; 17%). Mortality did not differ between patients with (8%) and without pacemaker (5%). The most common pacemaker indication was sinus node dysfunction (SND) (64%). Pacemaker implantation due to SND was less common among patients with EC. Pacemaker implantation was significantly more common in patients with mitral atresia (MA; 44%), double outlet right ventricle (DORV; 24%) and double inlet left ventricle (DILV; 20%). In contrast, patients with pulmonary atresia with intact ventricular septum and hypoplastic left heart syndrome were significantly less likely to receive a pacemaker (3% and 6%, respectively). ConclusionsThirteen percent of Fontan patients received a permanent pacemaker, most frequently due to SND. EC was associated with a significantly lower prevalence of pacemaker than LT. Permanent pacemaker was more common in patients with MA, DORV, and DILV.
50.	Alm, Fredrik, 1983-, et al. (creator_code:cre_t) Örebro University’s Nobel Day Festivities : Book of abstracts, 2023 2023. - 1 Editorial collection (other academic/artistic)

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