| 1. |
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| 2. |
- Bedoya-Reina, O. C., et al.
(author)
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Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
- 2021
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Journal article (peer-reviewed)abstract
- Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of neuroblastoma with different clinical risk groups and stages, including healthy adrenal gland. We compare tumor cell populations with embryonic mouse sympatho-adrenal derivatives, and post-natal human adrenal gland. We provide evidence that low and high-risk neuroblastoma have different cell identities, representing two disease entities. Low-risk neuroblastoma presents a transcriptome that resembles sympatho- and chromaffin cells, whereas malignant cells enriched in high-risk neuroblastoma resembles a subtype of TRKB+ cholinergic progenitor population identified in human post-natal gland. Analyses of these populations reveal different gene expression programs for worst and better survival in correlation with age at diagnosis. Our findings reveal two cellular identities and a composition of human neuroblastoma tumors reflecting clinical heterogeneity and outcome. Childhood neuroblastoma can be separated into high and low risk groups, with prognosis depending on age at diagnosis. Here, the authors show that low and high risk neuroblastoma tumours are composed of different cell types with different malignancy potential.
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| 5. |
- Christofer Juhlin, C., et al.
(author)
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Whole-exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene
- 2015
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In: Genes, Chromosomes and Cancer. - : Wiley: 12 months. - 1045-2257 .- 1098-2264. ; 54:9, s. 542-554
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Journal article (peer-reviewed)abstract
- As subsets of pheochromocytomas (PCCs) lack a defined molecular etiology, we sought to characterize the mutational landscape of PCCs to identify novel gene candidates involved in disease development. A discovery cohort of 15 PCCs wild type for mutations in PCC susceptibility genes underwent whole-exome sequencing, and an additional 83 PCCs served as a verification cohort for targeted sequencing of candidate mutations. A low rate of nonsilent single nucleotide variants (SNVs) was detected (6.1/sample). Somatic HRAS and EPAS1 mutations were observed in one case each, whereas the remaining 13 cases did not exhibit variants in established PCC genes. SNVs aggregated in apoptosis-related pathways, and mutations in COSMIC genes not previously reported in PCCs included ZAN, MITF, WDTC1, and CAMTA1. Two somatic mutations and one constitutional variant in the well-established cancer gene lysine (K)-specific methyltransferase 2D (KMT2D, MLL2) were discovered in one sample each, prompting KMT2D screening using focused exome-sequencing in the verification cohort. An additional 11 PCCs displayed KMT2D variants, of which two were recurrent. In total, missense KMT2D variants were found in 14 (11 somatic, two constitutional, one undetermined) of 99 PCCs (14%). Five cases displayed somatic mutations in the functional FYR/SET domains of KMT2D, constituting 36% of all KMT2D-mutated PCCs. KMT2D expression was upregulated in PCCs compared to normal adrenals, and KMT2D overexpression positively affected cell migration in a PCC cell line. We conclude that KMT2D represents a recurrently mutated gene with potential implication for PCC development. (c) 2015 The Authors. Genes, Chromosomes and Cancer Published by Wiley Periodicals, Inc.
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- Ask, Maria, et al.
(author)
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The Innovative Exploration Drilling and Data Acquisition Research School
- 2021
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In: NSG2021 27th European Meeting of Environmental and Engineering Geophysics. - : European Association of Geoscientists and Engineers.
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Conference paper (peer-reviewed)abstract
- The Innovative Exploration Drilling and Data Acquisition Research School (I-EDDA-RS) is aimed at educating emerging scientists and engineers in on-site drilling and geoscientific investigation technology for mining. I-EDDA-RS consists if a consortium of scientists and specialists from six universities and research institutes in Germany and Sweden. A central component of the research school is that the courses have hands-on components at drill sites, boreholes and repositories. In addition, a course on entrepreneurial skills required in the exploration industry is also included in I-EDDA-RS. The arrival of the Covid-19 pandemic resulted in altered plans. Instead of offering ten courses with strong field work, practical, and entrepreneurial components during 2020, four courses via distant learning were offered. While this was disappointing in many aspects, two of the courses attracted a larger group of students from a wider part of the world than original envisioned. Outreach via on-line and open webinars is also a route to explore, as a complement to meetings and conferences in real life. The I-EDDA-RS courses in 2021 welcomes students at MSc & PhD level, as well as experienced professionals for lifelong learning (c.f. https://www.iedda.eu/rs). The form and type of teaching is to be determined.
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| 10. |
- Carlsson, Axel C, et al.
(author)
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Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes : findings from two community based cohorts of elderly
- 2014
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In: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 237:1, s. 236-242
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Journal article (peer-reviewed)abstract
- BACKGROUND: Experimental evidence support soluble receptors for tumor necrosis factor alpha as important mediators of the underlying pathology leading to cardiovascular disease and cancer. However, prospective data concerning the relation between circulating soluble tumor necrosis factor receptor-1 (sTNFR1) and mortality in humans are lacking. We aimed to explore and validate the association between sTNFR1 and mortality, and to explore the influence of other established risk factors for mortality, including other inflammatory markers.METHODS: The association between serum sTNFR1and the risk for mortality was investigated in two community-based cohorts of elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 50%, n = 1005, mean age 70 years, median follow-up 7.9 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 775, mean age 77 years, median follow-up 8.1 years).RESULTS: In total, 101 participants in PIVUS and 274 in ULSAM died during follow-up. In multivariable Cox regression models adjusted for inflammation, lifestyle and established cardiovascular risk factors, one standard deviation (SD) higher sTNFR1 was associated with a hazard ratio (HR) for mortality of 1.37, 95% confidence interval (CI) 1.17-1.60, in PIVUS and HR 1.22, 95% CI 1.10-1.37 in ULSAM. Moreover, circulatingsTNFR1 was associated with cardiovascular mortality (HR per SD of sTNFR1, 1.24, 95% CI 1.07-1.44) and cancer mortality (HR per SD of sTNFR1, 1.32, 95% CI 1.11-1.57) in the ULSAM cohort. High levels of sTNFR1 identified individuals with increased risk of mortality among those with high as well as low levels of systemic inflammation.CONCLUSIONS: An association between circulating sTNFR1 and an increased risk for mortality was found and validated in two independent community-based cohorts. The future clinical role of sTNFR1 to identify high risk patients for adverse outcomes and mortality has yet to be determined.
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| 14. |
- Giese, R., et al.
(author)
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Monitoring at the CO2SINK Site : A Concept Integrating Geophysics, Geochemistry and Microbiology
- 2009
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In: Proceedings of the 9th International Conference on Greenhouse Gas Control Technologies (GHGT-9), 16–20 November 2008, Washington DC, USAGREENHOUSE GAS CONTROL TECHNOLOGIES 9. - : Elsevier BV. ; , s. 2251-2259
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Conference paper (other academic/artistic)abstract
- At the CO2SINK site (Ketzin, near Berlin, Germany), the pilot study for onshore CO2 storage in saline aquifers includes monitoring of the storage reservoir and the structures above using physical, chemical, and microbial observations. Seismic and geoelectric measurements have delivered the structural framework and monitor CO2 propagation between two observation wells. Borehole temperature data serves to derive information about in-situ formation temperatures and to detect processes related to the injection and movement of CO2 in the subsurface. Pressure measurements aim at ensuring safe operations and characterization of the reservoir. For a complete characterization of the CO2 storage process, the physical observations have to be complemented by chemical and biological probing, as fluid/fluid and fluid/rock interactions and microbial processes play an important role possibly affecting the stability of the reservoir and caprock. A newly developed Gas Membrane Sensor detected the CO2 breakthrough on the first monitoring well. Microbial investigations contributed in optimizing the injection borehole after recognizing organisms reducing its injectivity.
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| 19. |
- Juhlin, C., et al.
(author)
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Crustal reflectivity near the Archean-Proterozoic boundary in northern Sweden and implications for the tectonic evolution of the area
- 2002
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In: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 150:1, s. 180-197
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Journal article (peer-reviewed)abstract
- Sm–Nd isotope ratios of 1.9–1.8 Ga granitoids delineate the Archaean–Proterozoic boundary in northern Sweden, an important feature in the Fennoscandian Shield. The boundary strikes approximately WNW–ESE and is defined as a c. 20 km wide zone with juvenile Palaeoproterozoic rocks to the SSW and Archaean and Proterozoic rocks, derived to a large extent from Archaean sources, to the NNE. It therefore constitutes the strongly reworked margin of the old Archaean craton. Extrapolation of the boundary offshore into the Bothnian Bay and correlation with the marine reflection seismic BABEL Lines 2 and 3/4 indicates that the boundary dips to the south-southwest, consistent with interpretation of the Sm–Nd data. In order to tie the BABEL results with onshore surface geology and obtain detailed images of the uppermost crust a short (30 km of subsurface coverage) pilot profile was acquired in the Luleå area of northern Sweden during August 1999. The profile consisted of a high-resolution shallow component (1 kg shots) and a lower-resolution deep component (12 kg shots). Both components image most of the reflective crust, with the deep component providing a better image below 10 s. Comparison of signal penetration curves with data acquired over the Trans-Scandinavian Igneous Belt (a large batholith) indicate the transparent nature of the crust there to be caused by geological factors, not acquisition parameters. Lower crustal reflectivity patterns on the Luleå test profile are similar to those observed on the BABEL lines, suggesting the same lower crust onshore as offshore. Interpreted Archaean reflective upper crust in the NE extends below more transparent Proterozoic crust in the SW. This transparent crust contains a number of high-amplitude reflectors that may represent shear zones and/or mafic rock within granite intrusions. A marked boundary in the magnetic field in the SW has been interpreted as being the result of a gently west-dipping contact zone between meta-sediments and felsic volcanic rocks, however, the seismic data indicate a near-vertical structure in this area. By correlating the onshore and offshore seismic data we have better defined the location of the Archaean–Proterozoic boundary on the BABEL profiles. Our new interpretation of the crustal structure along the northern part of the BABEL Line 2 shows a more bi-vergent geometry than previous interpretations. Comparison of the re-interpreted crustal structure in northern Sweden with that found in the Middle Urals shows several similarities, in particular the accretion of a series of arcs to a stable craton. Based on this similarity and geological data, we deduce that a continental arc accreted to the southwestern margin of the Archaean craton at c. 1.87 Ga. Shortly thereafter, the Skellefte island arc underthrust the continental arc owing to a collision further to the southwest resulting in the bi-vergent crustal structure observed today.
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| 20. |
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| 21. |
- Juhlin, C, et al.
(author)
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Loss of parafibromin expression in a subset of parathyroid adenomas
- 2006
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In: Endocrine-related cancer. - : Bioscientifica. - 1351-0088 .- 1479-6821. ; 13:2, s. 509-523
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Journal article (peer-reviewed)abstract
- Inactivation of the hyperparathyroidism–jaw tumour syndrome (HPT– JT) gene, HRPT2, was recently established as a genetic mechanism in the development of parathyroid tumours. Its encoded protein parafibromin has tumour-suppressor properties that play an important role in tumour development in the parathyroids, jaws and kidneys. Inactivating HRPT2 mutations are common in HPT– JT and parathyroid carcinomas, and have been described in a few cases of parathyroid adenomas with cystic features. In this study, 46 cases of cystic parathyroid adenomas previously investigated for HRPT2 mutations were characterized with regard to MEN1 gene mutations, cyclin D1 expression and parafibromin expression. In normal tissues and cell lines, parafibromin was ubiquitously expressed. Furthermore, parafibromin was detected as a dominating nuclear and a weaker cytoplasmic signal in transfected cell lines. In the three parathyroid tumours with inactivating HRPT2 mutations parafibromin expression was not detectable, and in one of two cases with aberrantly sized parafibromin the protein was delocalized. Both high and low cyclin D1 levels were found among HRPT2-mutated and -unmutated tumours, suggesting that these events are not mutually exclusive in parathyroid tumour development. The presented data suggest that in the majority of benign parathyroid tumours the expression of parafibromin remains unaltered, while the loss of parafibromin expression is strongly indicative of gene inactivation through mutation of the HRPT2 gene.
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| 27. |
- Li, Shuijie, et al.
(author)
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Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
- 2022
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In: Nature Metabolism. - : Nature Publishing Group. - 2522-5812. ; 4:6, s. 739-758
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Journal article (peer-reviewed)abstract
- Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, whose alteration is linked to tumours arising in the von Hippel–Lindau syndrome. TFAM is hydroxylated by EGLN3 and subsequently bound by the von Hippel–Lindau tumour-suppressor protein, which stabilizes TFAM by preventing mitochondrial proteolysis. Cells lacking wild-type VHL or in which EGLN3 is inactivated have reduced mitochondrial mass. Tumorigenic VHL variants leading to different clinical manifestations fail to bind hydroxylated TFAM. In contrast, cells harbouring the Chuvash polycythaemia VHLR200W mutation, involved in hypoxia-sensing disorders without tumour development, are capable of binding hydroxylated TFAM. Accordingly, VHL-related tumours, such as pheochromocytoma and renal cell carcinoma cells, display low mitochondrial content, suggesting that impaired mitochondrial biogenesis is linked to VHL tumorigenesis. Finally, inhibiting proteolysis by targeting LONP1 increases mitochondrial content in VHL-deficient cells and sensitizes therapy-resistant tumours to sorafenib treatment. Our results offer pharmacological avenues to sensitize therapy-resistant VHL tumours by focusing on the mitochondria.
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| 28. |
- Lindfors, H, et al.
(author)
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Thyroglobulin expression, Ki-67 index, and lymph node ratio in the prognostic assessment of papillary thyroid cancer
- 2023
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 13:1, s. 1070-
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Journal article (peer-reviewed)abstract
- The clinical significance of thyroglobulin (Tg) expression in papillary thyroid cancer (PTC) has not been systematically explored in relation to the Ki-67 index, lymph node ratio (LNR), or other conventional prognostic predictors. In this retrospective study of 327 patients with PTC, we investigated the immunohistochemical expression of Tg in both primary tumors and their matching lymph node metastases in relation to the Ki-67 index, LNR, and clinical data. Tumoral Tg immunoreactivity was inversely correlated to the Ki-67 index and tumor recurrence. The Ki-67 index was higher in lymph node metastases (mean 4%) than in the primary tumors (mean 3%). Reduced Tg expression, estimated as 0–25% Tg positive tumor cells, was more common in lymph node metastases compared to primary tumors. In addition to advanced metastatic burden (defined as N1b stage and LNR ≥ 21%), low Tg expression (0–25% positive tumor cells) in lymph node metastases had a significant prognostic impact with shorter recurrence-free survival. These findings support the potential value of histopathological assessment of Tg expression and Ki-67 index in lymph node metastases as complementary predictors to anticipate the prognosis of PTC patients better.
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| 29. |
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| 31. |
- Nilsson, I. A. K., et al.
(author)
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Plasma neurofilament light chain concentration is increased in anorexia nervosa
- 2019
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In: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9
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Journal article (peer-reviewed)abstract
- Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality and, to a large extent, unknown pathophysiology. Structural brain differences, such as global or focal reductions in grey or white matter volumes, as well as enlargement of the sulci and the ventricles, have repeatedly been observed in individuals with AN. However, many of the documented aberrances normalize with weight recovery, even though some studies show enduring changes. To further explore whether AN is associated with neuronal damage, we analysed the levels of neurofilament light chain (NfL), a marker reflecting ongoing neuronal injury, in plasma samples from females with AN, females recovered from AN (AN-REC) and normal-weight age-matched female controls (CTRLS). We detected significantly increased plasma levels of NfL in AN vs CTRLS (median(AN) = 15.6 pg/ml, IQR(AN) = 12.1-21.3, median(CTRL) = 9.3 pg/ml, IQR(CTRL) = 6.4-12.9, and p < 0.0001), AN vs AN-REC (median(AN-REC) = 11.1 pg/ml, IQR(AN-REC) = 8.6-15.5, and p < 0.0001), and AN-REC vs CTRLS (p = 0.004). The plasma levels of NfL are negatively associated with BMI overall samples (beta (+/- se) = -0.62 +/- 0.087 and p = 6.9. 10(-12)). This indicates that AN is associated with neuronal damage that partially normalizes with weight recovery. Further studies are needed to determine which brain areas are affected, and potential long-term sequelae.
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| 32. |
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| 33. |
- Paulsson, Johan O., et al.
(author)
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Editorial Material: Absence of the BRAF V600E mutation in pheochromocytoma in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol 39, issue 6, pp 715-716
- 2016
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In: Journal of Endocrinological Investigation. - : SPRINGER. - 0391-4097 .- 1720-8386. ; 39:6, s. 715-716
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Journal article (other academic/artistic)abstract
- Purpose Pheochromocytomas (PCCs) are rare endocrine tumors originating from the adrenal medulla. These tumors display a highly heterogeneous mutation profile, and a substantial part of the causative genetic events remains to be explained. Recent studies have reported presence of the activating BRAF V600E mutation in PCC, suggesting a role for BRAF activation in tumor development. This study sought to further investigate the occurrence of the BRAF V600E mutation in these tumors. Methods A cohort of 110 PCCs was screened for the BRAF V600E mutation using direct Sanger sequencing. Results All cases investigated displayed wild-type sequences at nucleotide 1799 in the BRAF gene. Conclusions Taken together with all previously screened tumors up to date, only 1 BRAF V600E mutation has been found among 361 PCCs. These findings imply that the BRAF V600E mutation is a rare event in pheochromocytoma.
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| 40. |
- Ayarza, P, et al.
(author)
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Integrated geological and geophysical studies in the SG4 borehole area, Tagil Volcanic Arc, Middle Urals: Location of seismic reflectors and source of the reflectivity
- 2000
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In: Journal of Geophysical Research. - : AMER GEOPHYSICAL UNION. - 0148-0227 .- 2156-2202. ; 105:B9, s. 21333-21352
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Journal article (peer-reviewed)abstract
- Near-vertical incidence reflection seismic data acquired in the Tagil Volcanic Arc (Middle Urals) show the upper crust to be highly reflective. Two intersecting seismic lines located near the ongoing ∼5400 m deep SG4 borehole show that the main reflectivity strikes approximately N-S and dips ∼35°–55° to the east. Prominent reflections intercept the borehole at ∼1000, ∼1500, 2800–2900, ∼3400, and between ∼4000 and 5400 m, which correspond to intervals of low velocity/low density/low resistivity. The surface projections of these reflections lie parallel to the strike of magnetic anomaly trends. Multioffset vertical seismic profile (VSP) data acquired in the SG4 borehole show a seismic response dominated by P to S reflected converted waves from the moderately east dipping reflectivity and from a set of very steep east dipping reflectors not imaged by the surface data. Modeling of the VSP data constrains the depth at which reflectors intercept the borehole and suggests that the P to S conversions are best explained by low-velocity porous intervals rather than higher-velocity mafic material. The most prominent east dipping reflection on the surface seismic data is only imaged on VSP shots that sample the crust closer to the E-W seismic line. This discrepancy between the VSP and the surface seismic data is attributed to rapid lateral changes in the physical properties of the reflector. Surface and borehole data suggest that the low-velocity/low-density/low-resistivity intervals are the most important source of reflectivity in the SG4 borehole area, although lithological contrasts may also play a role. Drill cores from the these zones contain hydrothermal alteration minerals indicating interaction with fluids. Tectonic criteria suggest that they might represent imbricated fracture zones often bounding different lithologies and/or intrusions. Some of them might also represent high-porosity lava flows or pyroclastic units, common in island arc environments.
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| 41. |
- Backman, Samuel, et al.
(author)
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The Evolutionary History of Metastatic Pancreatic Neuroendocrine Tumours Reveals a Therapy Driven Route to High-Grade Transformation.
- 2024
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In: medRxiv : the preprint server for health sciences.
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Journal article (peer-reviewed)abstract
- Tumour evolution with acquisition of more aggressive disease characteristics is a hallmark of disseminated cancer. Metastatic pancreatic neuroendocrine tumours (PanNETs) in particular, show frequent progression from a low/intermediate to a high-grade disease. To understand the molecular mechanisms underlying this phenomenon, we performed multi-omics analysis of 32 longitudinal samples from six metastatic PanNET patients. Following MEN1 inactivation, PanNETs exhibit genetic heterogeneity on both spatial and temporal dimensions with parallel and convergent tumuor evolution involving the ATRX/DAXX and mTOR pathways. Following alkylating chemotherapy treatment, some PanNETs develop mismatch repair deficiency and acquire a hypermutator phenotype. This DNA hypermutation phenotype was only found in cases that also showed transformation into a high-grade PanNET. Overall, our findings contribute to broaden the understanding of metastatic PanNET, and suggests that therapy driven disease evolution is an important hallmark of this disease.
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| 42. |
- Batra, Gorav, et al.
(author)
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Data standards for atrial fibrillation/flutter and catheter ablation : The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
- 2023
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In: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 9:6, s. 609-620
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Journal article (peer-reviewed)abstract
- AIMS: Standardized data definitions are essential for monitoring and assessment of care and outcomes in observational studies and randomized controlled trials (RCTs). The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart) project of the European Society of Cardiology aimed to develop contemporary data standards for atrial fibrillation/flutter (AF/AFL) and catheter ablation.METHODS AND RESULTS: We used the EuroHeart methodology for development of data standards and formed a Working Group comprising 23 experts in AF/AFL and catheter ablation registries, as well as representatives from the European Heart Rhythm Association and EuroHeart. We conducted a systematic literature review of AF/AFL and catheter ablation registries and data standard documents to generate candidate variables. We used a modified Delphi method to reach consensus on a final variable set. For each variable, the Working Group developed permissible values and definitions, and agreed as to whether the variable was mandatory (Level 1) or additional (Level 2). In total, 70 Level 1 and 92 Level 2 variables were selected and reviewed by a wider Reference Group of 42 experts from 24 countries. The Level 1 variables were implemented into the EuroHeart IT platform as the basis for continuous registration of individual patient data.CONCLUSION: By means of a structured process and working with international stakeholders, harmonized data standards for AF/AFL and catheter ablation for AF/AFL were developed. In context of the EuroHeart project, this will facilitate country-level quality of care improvement, international observational research, registry-based RCTs and post-marketing surveillance of devices and pharmacotherapies.
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| 49. |
- Brown, D, et al.
(author)
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Crustal-scale structure and evolution of an arc-continent collision zone in the southern Urals, Russia
- 1998
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In: Tectonics. - : American Geophysical Union (AGU). - 0278-7407 .- 1944-9194. ; 17:2, s. 158-171
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Journal article (other academic/artistic)abstract
- The outcropping geology of the southern Urals contains a well-preserved accretionary complex related to the Paleozoic collision that took place between the Magnitogorsk arc and the former East European Craton. The crustal-scale structure of the accretionary complex has been determined from outcropping field geology that is integrated with three reflection seismic profiles. The reflection profiles show the accretionary complex to be highly reflective, allowing direct comparison of many reflections with surface geological features. We interpret the accretionary complex to be a thrust stack that is composed of shallowly subducted continental shelf and rise material, syncollisional sediments derived from the arc, deeply subducted high-pressure gneisses that are intercalated with eclogites and blueschist, and, at the highest structural level, ophiolite complexes. It is bound at the base by a thrust and at the rear by a highly deformed zone (the Main Uralian fault) adjacent to the backstop (the Magnitogorsk arc). Deposition of the Late Devonian volcaniclastic sediments of the Zilair Formation appears to be related to collision, uplift, and erosion of the arc, possibly following the arrival of the full thickness of the East European Craton continental crust at the subduction zone. With the arrival of the continental crust at the subduction zone, offscraping and underplating of Paleozoic slope and platform material took place at the base of the accretionary complex. Uplift of the arc was followed by its collapse and the unconformable deposition of Lower Carboniferous shallow water carbonates on top of it. A time lag of 10 - 15 Myr occurred between the high-pressure metamorphism and the subsequent arrival of the East European Craton at the subduction zone.
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| 50. |
- Brown D., Juhlin C., Tryggvason A., Steer D., Ayarza P., Beckholmen M., Rybalka A. and Bliznetsov M.
(author)
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The Crustal Architecture of the Southern and Middle Urals from the URSEIS, ESRU, and Alapaev Reflection Seismic Profiles, in Orogenic Processes in the Paleozoic Uralides
- 2002
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In: Geophysical Monograph Series, AGU. ; , s. 33-48
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Journal article (peer-reviewed)
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