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1.	De Backer, G, et al. (author) Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries 2019 In: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 285, s. 135-146 Journal article (peer-reviewed)
2.	Kadison, Stephanie R, et al. (author) EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. 2006 In: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 26:35 Journal article (peer-reviewed)abstract EphB receptors and their ephrin-B ligands are required for midline guidance decisions at several rostrocaudal levels of the developing CNS. In the embryonic vertebrate spinal cord, ephrin-B3 is localized to the floor plate (FP) at the ventral midline (VM), ephrin-B1 and ephrin-B2 are expressed in the dorsal spinal cord, and decussated EphB receptor-bearing commissural axons navigate between these ventral and dorsal ephrin-B domains. Despite these compelling expression patterns, the in vivo role(s) for EphB and ephrin-B proteins in regulating the guidance of spinal commissural axons has not been established. Here, we use DiI (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate) labeling to assess the pathfinding of commissural axons in the spinal cords of ephrin-B and EphB mutant mouse embryos. In mice lacking ephrin-B3 or multiple EphB receptors, a significant number of axons followed aberrant trajectories in the immediate vicinity of the VM. Furthermore, forked transverse commissural (FTC) axons, a unique class of commissural axons that continues to project in the transverse plane on the contralateral side of the FP, were present at a markedly higher frequency in ephrin-B3 and EphB mutants, compared with wild-type embryos. Neither the midline guidance errors nor excessive numbers of FTC axons were observed in the spinal cords of ephrin-B3(lacz) mice that express a truncated form of ephrin-B3, which is capable of forward but not reverse signaling. In contrast to the midline guidance defects observed in EphB and ephrin-B3 mutant embryos, wild-type-like contralateral projections were observed in mice lacking ephrin-B1 and/or ephrin-B2.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Mills, C. (1); Taylor, C. (1); Rydén, L. (1); Castro, A. (1); Baker, M. (1); Hernandez, S. (1); show more...; Barker, D. (1); Davletov, K (1); Vukovic, A (1); Delgado, J. (1); Martinez, G. (1); Guy, J. (1); Milicic, D (1); Lindsay, S. (1); Crowley, J (1); Sousa, J (1); Wright, J (1); Porter, J. (1); González, P. (1); Wagner, M. (1); Abreu, A (1); Vulic, D (1); Gaita, D (1); Haupt, A. (1); Mäkinen, Taija (1); Bozkurt, E (1); Youssef, M (1); Shahim, B (1); Maggioni, AP (1); Morganti, M. (1); Perez, A. (1); Kostic, S. (1); Aguiar, C (1); Kayikcioglu, M (1); Reiner, Z (1); Tokgozoglu, L (1); Marques-Vidal, P. (1); Bennett, C (1); Kelly, C (1); Craig, J (1); Tuomilehto, J. (1); Stork, S (1); De Backer, G (1); Deckers, JW (1); Stagmo, M (1); Ferreira, T (1); Kjellstrom, B. (1); Kordic, K (1); Vidal, A (1); De Smedt, D (1); show less...

University: Uppsala University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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