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1.	Suska, Felicia, 1974, et al. (author) In vivo evaluation of noble metal coatings 2010 In: Journal of Biomedical Materials Research Part B: Applied Biomaterials. - 1552-4981. ; 92B:1, s. 86-94 Journal article (peer-reviewed)abstract A nanotopographic noble metal (Ag, Au, Pd) coating has been applied on commercial urinary catheters and used in more than 80,000 patients, with good clinical results. We have previously evaluated the biocompatibility of different variations of this coating, showing high cellular viability and function in vitro. However, the reasons for good clinical and preclinical behavior are not known. This in vivo study aimed to investigate the soft tissue peri-implant reaction to five coatings with systematically altered noble metal ratios after 1, 3, and 21 days of implantation in rats. The results show that coatings of silver only, or silver with medium amounts of gold and low-medium palladium content were superior to other tested coatings. Such surfaces were during the first days after implantation associated with a decreased recruitment of inflammatory cells to implant close exudates, a lower percentage of neutrophils, higher cell viability, and lower production of monocyte chemoattractant protein-1 (MCP-1), compared to the other coatings and uncoated silicone (PDMS) control. In contrast, the addition of higher concentrations of gold and palladium to silver induced a thicker soft tissue capsule. Coatings with high concentration of palladium induced the thickest fibrouscapsule after 21 days of implantation. The study demonstrates that by varying the noble metal ratio at implant surfaces it is possible to modulate inflammation and fibrosis in soft tissue.
2.	Svensson, Sara, 1981, et al. (author) Bone response to antimicrobial noble metal nano-coating on titanium implants 2010 In: European Association for Osseointegration (EAO), 19th annual scientific meeting, 6-9 October, Glasgow, UK. Conference paper (peer-reviewed)
3.	Svensson, Sara, 1981, et al. (author) In Vivo Evaluation of Antimicrobial Noble Metal-Coatings 2008 In: Abstract, 8th World Biomaterials Congress, Amstrdam, The Netherlands. Conference paper (peer-reviewed)
4.	Svensson, Sara, 1981, et al. (author) Monocyte behavior on gold and palladium surfaces 2009 In: Abstract, 22nd European Conference on Biomaterials, Lausanne, Switzerland. ; 7-11 September Conference paper (peer-reviewed)
5.	Svensson, Sara, 1981, et al. (author) Nanostructured noble metals on implants in vitro and in vivo 2011 In: Abstract, 4th Annual Meeting, Scandinavian Society for Biomaterials, Fiskebäckskil, Sweden. ; 21:S1, s. 50- Conference paper (peer-reviewed)

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Type of publication: conference paper (4); journal article (1)

Type of content: peer-reviewed (5)

Author/Editor: Thomsen, Peter, 1953 (5); Suska, Felicia, 1974 (5); Svensson, Sara, 1981 (5); Ohrlander, Mattias (5); Karlholm, Helen (5); Johansson, Anna, 196 ... (4); show more...; Emanuelsson, Lena, 1 ... (4); Lausmaa, Jukka (3); Rydja, Gunilla (3); Palmquist, Anders, 1 ... (2); Norlindh, Birgitta, ... (2); Agheli, Hossein, 196 ... (1); Petronis, Sarunas, 1 ... (1); Trobos, Margarita, 1 ... (1); Lennerås, Maria, 198 ... (1); show less...

University: University of Gothenburg (5); Chalmers University of Technology (1); RISE (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (5)

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