| 1. |
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| 2. |
- Andersson, Magnus, et al.
(author)
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Fiskbestånd och miljö i hav och sötvatten : Resurs- och miljööversikt 2012
- 2012
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Reports (other academic/artistic)abstract
- Detta är den nionde utgåvan av den samlade översikten över fisk- och kräftdjursbeståndens status i våra vatten. Kunskap om fiskbestånden och miljön är en förutsättning för att utnyttjandet av fiskresurserna skall bli bärkraftigt. För svenska vattenområden beskrivs miljöutvecklingen i ett ekosystemsperspektiv, dels för att tydliggöra fiskens ekologiska roll och beskriva yttre miljöfaktorer som påverkar fiskbestånden, dels för att belysa fiskets effekter på miljön.Fiskbestånd och miljö i hav och sötvatten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten. Rapporten sammanfattar utveckling och beståndsstatus för de kommersiellt viktigaste fisk- och kräftdjursarterna i våra vatten. Bedömningar och förvaltningsråd är baserade på Internationella Havsforskningsrådets (ICES) rådgivning, SLU Aquas nationella och regionala provfiskedata, samt yrkesfiskets rapportering.
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| 3. |
- Granstam, Elisabet, et al.
(author)
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Reduced occurrence of severe visual impairment after introduction of anti-Vascular Endothelial Growth Factor in wet age-related macular degeneration : a population- and register-based study from northern Sweden
- 2016
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In: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 94:7, s. 646-651
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Journal article (peer-reviewed)abstract
- PurposeTo study the occurrence of severe visual impairment (SVI) and treatment outcome at 12months in patients treated for wet age-related macular degeneration (AMD) by use of data from the Swedish Macula Register (SMR) and referrals to the regional low vision clinics in five northern counties. MethodsReferrals to low vision clinics during 2005, 2009 and 2013 and treatment outcome at 12months from the SMR database from 2008 until 2013 in patients >65years of age in five northern counties were included in the survey. ResultsThe rate of referral due to AMD was significantly reduced during the time period (-48%; p<0.001). At 12months, a significant slight mean improvement in logMAR visual acuity (VA) was observed (-0.01, SD 0.37; p<0.001) after a mean of 5.02.3 anti-vascular endothelial growth factor (VEGF)-injections were administered. Age and low baseline VA was associated with less favourable visual outcome (p<0.001). ConclusionReferral rate to low vision clinic is a valuable tool for estimating occurrence of SVI and fell between the years 2005 until 2013. Data from the SMR showed improvement in visual acuity on the whole, but also identified patients at high risk for developing SVI during anti-VEGF-treatment.
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| 4. |
- Gustafsson, Anna W, et al.
(author)
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Att vårda sin vetenskap
- 2012
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In: Med språket som arbetsredskap: Sju studier av kommunikation i vården. - 9789186069537 ; , s. 119-136
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Book chapter (peer-reviewed)
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| 5. |
- Gustafsson, Anna W, et al.
(author)
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Finns det någon gräns för språkvetenskapen?
- 2017
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In: Varför språkvetenskap? : kunskapsintressen, studieobjekt och drivkrafter - kunskapsintressen, studieobjekt och drivkrafter. - 9789144108902 ; , s. 219-236
-
Book chapter (peer-reviewed)
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| 6. |
- Karlsson, Anna-Carin, et al.
(author)
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Ethical challenges in residential care facilities during COVID-19 : Leaders' perspective
- 2024
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In: Nursing Ethics. - : SAGE Publications Ltd. - 0969-7330 .- 1477-0989.
-
Journal article (peer-reviewed)abstract
- BACKGROUND : Person-centred care is based on ethical principles, and it is regarded as high-quality care. Care of older persons should embrace person-centredness. During the pandemic, older persons were highlighted as a vulnerable group at risk of developing serious illness and/or suffering death from COVID-19. Several pandemic-related measures were introduced in residential care facilities (RCFs) to reduce this risk, which influenced the possibilities to lead and provide a person-centred care. AIM : This study's aim was to explore ethical challenges in relation to person-centredness during the COVID-19 pandemic, from the perspective of leaders in RCFs. RESEARCH DESIGN : The study had a qualitative descriptive design. PARTICIPANTS AND RESEARCH CONTEXT : Semi-structured interviews were conducted with 26 leaders working in RCFs in Sweden. Data were analysed using conventional content analysis. ETHICAL CONSIDERATIONS: The study was approved by the Swedish Ethical Review Authority. The participants received oral and written information about the study and gave written consent. The study was conducted in accordance with the Declaration of Helsinki. FINDINGS : The overarching ethical challenge was Having to disregard the individual needs of the person in order to protect the group and society. This included (a) Protecting the group versus promoting the older person's autonomy; (b) Being forced to lead care based on uncertainty instead of evidence; (c) Striving to provide dignified care but lacking opportunities; and (d) Going far beyond ordinary duty and endangering one's own and the staff's health. DISCUSSION : The ethical challenges meant being torn between the person's individual needs and protecting the group and society, with clashing ethical principles as a consequence. CONCLUSIONS : The leaders faced ethical situations resulting in undignified and compromised person-centred care, which has implications for stakeholders and management who need to address the work conditions in RCFs.
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| 7. |
- Karlsson, Anna-Carin, et al.
(author)
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Ethical challenges in residential care facilities during COVID-19 : leaders’ perspective
- 2024
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In: Nursing Ethics. - : Sage Publications. - 0969-7330 .- 1477-0989.
-
Journal article (peer-reviewed)abstract
- Background: Person-centred care is based on ethical principles, and it is regarded as high-quality care. Care of older persons should embrace person-centredness. During the pandemic, older persons were highlighted as a vulnerable group at risk of developing serious illness and/or suffering death from COVID-19. Several pandemic-related measures were introduced in residential care facilities (RCFs) to reduce this risk, which influenced the possibilities to lead and provide a person-centred care.Aim: This study’s aim was to explore ethical challenges in relation to person-centredness during the COVID-19 pandemic, from the perspective of leaders in RCFs.Research design: The study had a qualitative descriptive design.Participants and research context: Semi-structured interviews were conducted with 26 leaders working in RCFs in Sweden. Data were analysed using conventional content analysis.Ethical considerations: The study was approved by the Swedish Ethical Review Authority. The participants received oral and written information about the study and gave written consent. The study was conducted in accordance with the Declaration of Helsinki.Findings: The overarching ethical challenge was Having to disregard the individual needs of the person in order to protect the group and society. This included (a) Protecting the group versus promoting the older person’s autonomy; (b) Being forced to lead care based on uncertainty instead of evidence; (c) Striving to provide dignified care but lacking opportunities; and (d) Going far beyond ordinary duty and endangering one’s own and the staff’s health.Discussion: The ethical challenges meant being torn between the person’s individual needs and protecting the group and society, with clashing ethical principles as a consequence.Conclusions: The leaders faced ethical situations resulting in undignified and compromised person-centred care, which has implications for stakeholders and management who need to address the work conditions in RCFs.
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| 8. |
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| 9. |
- Karlsson, Oskar, et al.
(author)
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Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression and neurodegeneration in adult hippocampus.
- 2012
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In: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-0929 .- 1096-6080. ; 130:2, s. 391-404
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Journal article (peer-reviewed)abstract
- The cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) has been proposed to contribute to neurodegenerative disease. We have previously reported a selective uptake of BMAA in the mouse neonatal hippocampus and that exposure during the neonatal period causes learning and memory impairments in adult rats. The aim of this study was to characterize effects in the brain of 6-month-old rats treated neonatally (postnatal days 9-10) with the glutamatergic BMAA. Protein changes were examined using the novel technique Matrix-Assisted Laser Desorption Ionization (MALDI) imaging mass spectrometry (IMS) for direct imaging of proteins in brain cryosections, and histological changes were examined using immunohistochemistry and histopathology. The results showed long-term changes including a decreased expression of proteins involved in energy metabolism and intracellular signaling in the adult hippocampus at a dose (150 mg/kg) that gave no histopathological lesions in this brain region. Developmental exposure to a higher dose (460 mg/kg) also induced changes in the expression of S100β, histones, calcium- and calmodulin-binding proteins, and guanine nucleotide-binding proteins. At this dose, severe lesions in the adult hippocampus including neuronal degeneration, cell loss, calcium deposits, and astrogliosis were evident. The data demonstrate subtle, sometimes dose-dependent, but permanent effects of a lower neonatal dose of BMAA in the adult hippocampus suggesting that BMAA could potentially disturb many processes during the development. The detection of BMAA in seafood stresses the importance of evaluating the magnitude of human exposure to this neurotoxin.
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| 10. |
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| 11. |
- Robba, Chiara, et al.
(author)
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
- 2022
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In: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 26, s. 1-13
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Journal article (peer-reviewed)abstract
- Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016.
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| 12. |
- Robba, Chiara, et al.
(author)
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Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients : a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
- 2022
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In: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 48:8, s. 1024-1038
-
Journal article (peer-reviewed)abstract
- Purpose: The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Methods: Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. Results: A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (VT) was 7 (Interquartile range, IQR = 6.2–8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5–9) cmH20, plateau pressure was 20 cmH20 (IQR = 17–23), driving pressure was 12 cmH20 (IQR = 10–15), mechanical power 16.2 J/min (IQR = 12.1–21.8), ventilatory ratio was 1.27 (IQR = 1.04–1.6), and respiratory rate was 17 breaths/minute (IQR = 14–20). Median partial pressure of oxygen was 87 mmHg (IQR = 75–105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36–45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003–1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001–1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Conclusions: Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
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| 13. |
- Ståhle, Alexander, et al.
(author)
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Designguide för Smarta gator
- 2022
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Book (other academic/artistic)abstract
- Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
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| 14. |
- Thorgeirsdottir, Lilja, et al.
(author)
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Study protocol: establishment of a multicentre pre-eclampsia database and biobank in Sweden: GO PROVE and UP MOST, a prospective cohort study
- 2021
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In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 11:11
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Journal article (other academic/artistic)abstract
- Introduction Pre-eclampsia, a multisystem disorder in pregnancy, is one of the most common causes of maternal morbidity and mortality worldwide. However, we lack methods for objective assessment of organ function in pre-eclampsia and predictors of organ impairment during and after pre-eclampsia. The women’s and their partners’ experiences of pre-eclampsia have not been studied in detail. To phenotype different subtypes of the disorder is of importance for prediction, prevention, surveillance, treatment and follow-up of pre-eclampsia.The aim of this study is to set up a multicentre database and biobank for pre-eclampsia in order to contribute to a safer and more individualised treatment and care.Methods and analysis This is a multicentre cohort study. Prospectively recruited pregnant women ≥18 years, diagnosed with pre-eclampsia presenting at Sahlgrenska University Hospital, Uppsala University Hospital and at Södra Älvsborgs Hospital, Sweden, as well as normotensive controls are eligible for participation. At inclusion and at 1-year follow-up, the participants donate biosamples that are stored in a biobank and they are also asked to participate in various organ-specific evaluations. In addition, questionnaires and interviews regarding the women’s and partner’s experiences are distributed at follow-up.Ethics and dissemination By creating a database and biobank, we will provide the means to explore the disorder in a broader sense and allow clinical and laboratory discoveries that can be translated to clinical trials aiming at improved care of women with pre-eclampsia. Further, to evaluate experiences and the psychological impact of being affected by pre-eclampsia can improve the care of pregnant women and their partners. In case of incidental pathological findings during examinations performed, they will be handled in accordance with clinical routine. Data are stored in a secure online database. Biobank samples are identified through the women’s personal identification number and pseudonymised after identification in the biobank before analysis.This study was approved by the regional ethical review board in Gothenburg on 28 December 2018 (approval number 955-18) and by the Swedish Ethical Review Authority on 27 February 2019 (approval number 2019-00309).
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| 15. |
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| 16. |
- Åberg-Bengtsson, Lisbeth, et al.
(author)
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När Agnes fick va solen så fattade man ju precis : Om illustrationer i undervisning av yngre elever
- 2014
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In: Resultatdialog. - Stockholm : Vetenskapsrådet. - 9789173072472 ; , s. 246-254
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Book chapter (other academic/artistic)abstract
- Att göra adekvata tolkningar av bilder och modeller kan vara verkliga stötestenar för många barn. Särskilt besvärligt förefaller det vara att tolka bilder av processer och förlopp i tryckta läromedel. Även enk-lare bilder och vanliga symboler kan dock leda till icke avsedda tolkningar. Barnen i studien föreföll i många fall betrakta illustrationerna som enbart dekoration och förbigick dem ofta om de inte direkt uppmärksammades på dem. Å andra sidan kunde illustrationer också, särskilt sådana som visade på extremer av något slag, väcka förundran och intresse.
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| 17. |
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Analysing text AND talk : Att analysera texter OCH samtal
- 2014
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Editorial collection (other academic/artistic)abstract
- This report originates in two workshops on text and talk, one held in Sweden and one in Finland. It aims at exploring the intersections of text analysis and conversation analysis, and at highlighting the current themes of this field of research.List of contributions:Anna-Malin Karlsson & Henna Makkonen-Craig: Texts and conversations: traditions and perspectives from Sweden and FinlandLinnea Hanell & Mona Blåsjö: Diskurs i handling: Att studera människors handlingar med medierad diskursanalysSuvi Honkanen & Riikka Nissi: Managing organizational change through joint vision building: an analysis of practices of recontextualizationKarin Hagren Idevall & Theres Bellander: Membership Categorization Analysis – för analyser av kategoriseringar i tal och skriftAnna-Malin Karlsson: Evaluering för alla? Eller: Den farliga skriftenMats Landqvist: Positionering och validitet i enkäter och fokusgruppssamtalHenna Makkonen-Craig: Aspects of dialogicity: Exploring dynamic interrelations in written discourseHenna Makkonen-Craig: The emergence of a research tradition: Dialogically-oriented linguistic discourse analysis
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| 18. |
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| 19. |
- Bellander, Theres, et al.
(author)
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Patient participation and learning in medical consultations about congenital heart defects
- 2019
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:7
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Journal article (peer-reviewed)abstract
- In this article, patient activity in 8 audio recorded specialist consultations on fetal cardiology is investigated in order to explore how, why and when patients tend to participate in encounters in which the doctor dominates the interaction. The overall question is: How can the participation of patients in the consultations be connected to the development of higher levels of health literacy, i.e. to interactive literacy and to critical literacy? Patient participation is here understood as interactive action and is analyzed in terms of different interactive moves, which are related to different recurring topics. Despite the highly standardized format of the consultations, there is a large variation between the patients’ participation: between 0.7 and 2.8 moves per minute. The patients participate most during the topics ‘Prevalence’ and ‘Consultations’ and least during the topic ‘The normal heart’. Although most of the patients' moves are responses to what the doctor says, they remarkably often pose questions and use so called rejoinders. By posing questions, they take control of the information flow and sometimes even change the topics. By using rejoinders, they analyze the problems involved in the discussion e.g. by asking for clarifications or confirmation. Patients with a low over-all participation rate also use fewer moves that indicate higher literacy levels. The qualitative analysis problematizes the idea of a simple scale from basic literacy to critical literacy. Moves that indicate basic literacy skills are interactively important for the learning activity, led by the doctor. However, patients who mainly support the doctor’s initiatives don’t take the opportunity to influence the flow of information in ways that might favor their health literacy development.
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| 20. |
- Bellander, Theres, 1977-
(author)
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Ungdomars dagliga interaktion : En språkvetenskaplig studie av sex gymnasieungdomars bruk av tal, skrift och interaktionsmedier
- 2010
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Doctoral thesis (other academic/artistic)abstract
- This thesis explores young people's interaction with different individuals through a variety of media. Three girls and three boys aged 16–18, from an urban school, a rural school and a suburban school, were each observed for a week, at school, at home and during leisure activities. The data analysed consist of field notes, video and audio recordings, and texts written by the participants. The aim of the study is to investigate how young people’s use of language varies in relation to different contexts. Questions are asked about what activities they participate in, what media they use and how they use them, and how they express themselves orally and in writing in different contexts and through different media. The study is based in sociolinguistic theory and activity type theory. Data were collected using ethnographical methods, and analytical tools were drawn from a broadly defined field of discourse analysis. The investigation sheds light on the relationship between what young people are doing socially in any given situation and how they interact. Variation in linguistic styles is made visible by a study of the same individuals involved in different communicative activities. Young people are shown to be a heterogeneous group who engage in different sets of activities. The study questions prevailing definitions and categorisations of adolescents’ linguistic styles and use of electronic media. The outcome is a complex description of everyday interaction, which is found to be shaped by the frames for communicative activities, the technical characteristics of the media employed, and individual factors. In conversational turns, Internet chat messages and text messages, young people select resources from their individual linguistic repertoires in order to achieve specific goals or construct particular roles through their interaction.
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| 21. |
- Bianchi, Marco, 1974-
(author)
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Runor som resurs : Vikingatida skriftkultur i Uppland och Södermanland
- 2010
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Doctoral thesis (other academic/artistic)abstract
- The Viking Age rune-carvers and their readers used runes as a semiotic resource to convey and structure the messages on rune-stones. An analysis of the ways in which this resource is used together with other resources gives us a deeper insight into the relationship between writers and readers and into the written culture in which the rune-stones were produced.The present study treats runic carvings as multimodal texts in which different semiotic modes produce meaning by visual and verbal means. The roles played by runes in such texts are studied from three different perspectives. The empirical study in chapter 3 investigates how the verbal messages of the inscriptions interrelate with ornamental compositions. The most important convention found is that runic inscriptions usually start in the lower left part of the ornamental band in which they are inscribed. A second result is that there is a certain correlation between the visual and syntactic structure of runic texts. In chapter 4, Södermanlandic inscriptions employing more than one writing system are investigated. These carvings can be tied to a context of high social ambition in which at least two different, socially stratified discourses are expressed by means of the runes as a visual semiotic mode. Chapter 5 is devoted to non-lexical inscriptions, showing that such carvings are indeed runic texts despite their lack of verbal message.Different types of readers can use runic resources in different ways. Firstly, runes carry meaning independent of any verbal message, giving them significance even to illiterate readers. Secondly, literate readers can appreciate certain conventions of runic composition and, thirdly, one and the same runic text can be part of different discourses and hence be aimed at different kinds of readers.
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| 22. |
- Björkvall, Anders, 1972-, et al.
(author)
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The materiality of discourses and the semiotics of materials : A social perspective on the meaning potentials of written texts and furniture
- 2011
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In: Semiotica. - : Walter de Gruyter. - 0037-1998 .- 1613-3692. ; 187:1-4, s. 141-165
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Journal article (peer-reviewed)abstract
- Based on two studies of different meaning-making phenomena, post-it notes and furniture, this paper highlights the role of materiality in everyday semiosis. A perspective on the semiotics of material artifacts is adopted, in which the “social” in combination with the specific affordances of materials are crucial for meaning-making. Partially in opposition to a Saussurean view of the semiotic sign, it is argued that materiality in itself contributes to meaning-making, through discourses and activity types. This paper contributes to the theoretical and the methodological dialogue between social semiotics and other approaches in the wider field of semiotic research.
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| 23. |
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| 24. |
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| 25. |
- Carlsson, Tommy, et al.
(author)
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Content and quality of information websites about congenital heart defects following a prenatal diagnosis
- 2015
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In: Interactive Journal of Medical Research. - : JMIR Publications Inc.. - 1929-073X. ; 4:1, s. 66-76
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Journal article (peer-reviewed)abstract
- BACKGROUND: Pregnant women and their partners use the Internet to search for information following a prenatal diagnosis of congenital heart defect.OBJECTIVE: Our aim was to explore central subjects of content and to assess the accessibility, reliability, usability, and quality of written information on publicly available information websites about congenital heart defects following a prenatal diagnosis.METHODS: Following searches on Bing and Google, we included websites containing patient information in English. Hits ranged from 340,000-67,500,000 and the first 50 hits from each search were screened for inclusion (N=600). Of these hits, 39.3% (236/600) were irrelevant. A total of 67 websites were included, of which 37% (25/67) were affiliated with independent information websites, 25% (17/67) with charity/private organizations, 25% (17/67) with hospitals/clinics, and 13% (8/67) had other affiliations. The majority of the websites (76%, 51/67) could not be attributed to an author. A manifest content analysis was performed to explore central subjects of content. The DISCERN instrument was used to assess the quality of information, and the LIDA tool was used to assess accessibility, usability, and reliability of the included websites.RESULTS: The content on the majority of the websites included care and treatment of children with congenital heart defects (88%, 59/67), causes of congenital heart defects (88%, 59/67), symptoms of congenital heart defects (85%, 57/67), prevalence of congenital heart defects (81%, 54/67), potential complications of congenital heart defects (75%, 50/67), prenatal diagnostics/screening methods (72%, 48/67), and specific congenital heart defects (72%, 48/67), whereas less than 10% included information about termination of pregnancy (6%, 4/67), care during pregnancy (5%, 3/67), and information specifically directed to partners (1%, 1/67). The mean of the total DISCERN score was 27.9 (SD 9.7, range 16-53). According to the instrument, a majority of the websites were categorized as very poor regarding information about effects of no treatment (88%, 59/67), support for shared decision making (85%, 57/67), achievement of its aims (84%, 56/67), explicit aims (82%, 55/67), risks of each treatment (82%, 55/67), how treatment choices affect overall quality of life (76%, 51/67), and areas of uncertainty (76%, 51/67). The mean of the total LIDA score was 92.3 (SD 13.1, range 61-127). According to the tool, a majority of the websites were categorized as good with regard to registration (97%, 65/67) and browser test (75%, 50/67), whereas a majority were categorized as poor with regard to currency (87%, 58/67), content production (84%, 56/67), and engagability (75%, 50/67).CONCLUSIONS: Difficulties in finding relevant information sources using Web search engines and quality deficits on websites are an incentive for health professionals to take an active part in providing adequate and reliable information online about congenital heart defects.
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| 26. |
- Carlsson, Tommy, et al.
(author)
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Experiences of termination of pregnancy for a fetal anomaly : A qualitative study of virtual community messages.
- 2016
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In: Midwifery. - : Elsevier BV. - 0266-6138 .- 1532-3099. ; 41, s. 54-60
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Journal article (peer-reviewed)abstract
- OBJECTIVE: to explore experiences described by posters in Swedish virtual communities before, during and after termination of pregnancy due to a fetal anomaly.DESIGN: cross-sectional qualitative study of messages in virtual communities. The messages were purposefully selected in 2014 and analyzed with inductive qualitative manifest content analysis.SETTING: two large and active Swedish virtual communities.SAMPLE: 1623 messages from 122 posters (112 females, 1 male, and 9 did not disclose their sex), written between 2008 and 2014. The majority of the posters were females (91%) with recent experience of termination of pregnancy following different prenatal diagnoses (63% less than one year since the termination).MEASUREMENTS AND FINDINGS: before the termination, posters experienced an emotional shock and a difficult decision. During the termination, they needed compassionate care from present caregivers, experienced intense emotional and physical pain, lacked an understanding about the abortion, and expressed varied feelings about the option to view the fetus. After the termination, posters used different strategies to come to terms with and accept the decision, experienced a perinatal loss, expressed fears of recurrence, and longed for a new child.KEY CONCLUSIONS: spanning across the time before, during and after the abortion, women who terminate a pregnancy due to a fetal anomaly express considerable physical and emotional pain, with psychosocial and reproductive consequences.IMPLICATIONS FOR PRACTICE: information and preparation, including the decision whether or not to view the fetus, are important aspects to consider when caring for individuals who have decided to terminate a pregnancy for a fetal anomaly. The findings indicate a need for structures that offer support to women who suffer from fears of recurrence in future pregnancies.
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| 27. |
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| 28. |
- Falk, Malin Värmå, et al.
(author)
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A qualitative study of facilitators and barriers to participate in a needle exchange program for women who inject drugs
- 2020
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In: Harm Reduction Journal. - : BMC. - 1477-7517. ; 17:1
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Journal article (peer-reviewed)abstract
- Background Women who inject drugs (WWID) show higher levels of injecting risk behaviour compared to men, putting them at risk of contracting HIV and hepatitis C (HCV). Compared to men, WWID are also less present in harm reduction programs such as needle exchange programs (NEP). The aim of this study is to investigate reasons for, and barriers to, participation in NEP among WWID in Sweden, and to identify measures that could be taken to strengthen the program and increase participation among WWID. Method In-depth interviews (IDIs) were conducted with 20 WWID who had participated in the Stockholm NEP for at least six months and was over 18 years old. IDIs were audio recorded and transcribedet verbatim. Qualitative content analysis was used to identify themes. Results The need for sterile injection equipment was identified as the main driver to join and remain in the NEP program. Continuous participation in the NEP was further driven by easy access to a multitude of health-related services. The most valued service was the sexual and reproductive health services (SRHR), allowing participants to access contraceptives, cervical cancer screening and sexually transmitted infections testing (STI-testing). NEP staffs' respectful treatment of participants further contributed to program participation. However, participants also expressed a number of concerns around NEP participation, which created barriers to joining. These included losing custody or visitation rights to children, male partner jealousy and violence, unwillingness to spend time in the waiting area and fear of receiving positive HIV/HCV test results. Practical barriers included limited opening hours and travel distance to the NEP. To strengthen the program, most participants requested additional SRHR services. Most participants also proposed some form of "women only" access to the NEP, to strengthen the feeling of the NEP as a safe space. Conclusion This study identified factors that may increase uptake of NEP among WWID. Additional SRHR services and "women only" access are recommended to be implemented and evaluated as part of NEP. These findings may inform and improve the current scale-up of NEPs in Sweden to ensure equal access to services.
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| 29. |
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Funktionell textanalys
- 2019. - 2
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Editorial collection (other academic/artistic)abstract
- Den systemisk-funktionella grammatiken (SFG) har på senare år blivit alltmer populär i Sverige. Skrivdidaktiker och textforskare tilltalas av modellen och använder de grammatiska kategorierna i analyser och undervisning. Kanske kan detta förklaras av den starka förankringen i kontexten - SFG fungerar helt enkelt bra för att beskriva språk i sammanhang, liksom för att analysera hur språket är med och skapar sammanhang. Analysen är dock inte alltid enkel, utan kräver att man vänder och vrider på perspektiven. En bra hjälp är förstås att titta på andras analyser. Den möjligheten erbjuder denna bok.Bokens tre redaktörer har samlat sina erfarenheter av grammatisk analys av texter, och inleder bokens olika avdelningar med kapitel som tar upp dels grunderna i analysen, dels tänkbara problem och överväganden.I kapitlen analyseras många olika slags texter, till exempel reklam, platsannonser, elevinsändare, vigselordningar och styrdokument för skolan. Författarnas ambition är att ge en god inblick i hur den systemisk-funktionella grammatiken kan användas för att analysera texter. Funktionell textanalys ges numera ut av Studentlitteratur AB. Denna andra upplaga innehåller dock inga förändringar av innehållet jämfört med den första upplagan.
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| 30. |
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| 31. |
- Fäldt, Jenny, 1971, et al.
(author)
-
Activation of human neutrophils by mycobacterial phenolic glycolipids.
- 1999
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In: Clinical and experimental immunology. - 0009-9104. ; 118:2, s. 253-60
-
Journal article (peer-reviewed)abstract
- The interaction between mycobacterial phenolic glycolipids (PGLs) and phagocytes was studied. Human neutrophils were allowed to interact with each of four purified mycobacterial PGLs and the neutrophil production of reactive oxygen metabolites was followed kinetically by luminol-/isoluminol-amplified chemiluminescence. The PGLs from Mycobacterium tuberculosis and Mycobacterium kansasii, respectively, were shown to stimulate the production of oxygen metabolites, while PGLs from Mycobacterium marinum and Mycobacterium bovis BCG, respectively, were unable to induce an oxidative response. Periodate treatment of the M. tuberculosis PGL decreased the production of oxygen radicals, showing the importance of the PGL carbohydrate moiety for the interaction. The activation, however, could not be inhibited by rhamnose or fucose, indicating a complex interaction which probably involves more than one saccharide unit. This is in line with the fact that the activating PGLs from M. tuberculosis and M. kansasii contain tri- and tetrasaccharides, respectively, while the nonactivating PGLs from M. marinum and M. bovis BCG each contain a monosaccharide. The complement receptor 3 (CR3) has earlier been shown to be of importance for the phagocyte binding of mycobacteria, but did not appear to be involved in the activation of neutrophils by PGLs. The subcellular localization of the reactive oxygen metabolites formed was related to the way in which the glycolipids were presented to the cells.
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| 32. |
- Fäldt, Jenny, 1971, et al.
(author)
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Priming of human neutrophils by mycobacterial lipoarabinomannans: role of granule mobilisation.
- 2001
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In: Microbes and infection. - 1286-4579. ; 3:13, s. 1101-9
-
Journal article (peer-reviewed)abstract
- Lipoarabinomannans (LAMs) from mycobacteria were investigated concerning their effect on human neutrophils. Two types of LAM, the mannose-capped ManLAM from the virulent Mycobacterium tuberculosis H37Rv and the mannose-lacking AraLAM from a rapidly growing mycobacterial strain were used. Neither AraLAM nor ManLAM induced any significant direct activation of the NADPH-oxidase. Both LAMs, however, primed the neutrophils so that subsequent stimulation with the peptide chemoattractants fMet-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-DMet (WKYMVm) and the mammalian lactose-binding lectin galectin-3 resulted in a markedly enhanced oxidative response. The LAM-induced priming was accompanied by an increased exposure of complement receptors 1 and 3 as well as the formyl peptide receptor on the neutrophil surface, suggesting that the enhanced oxidative response could be due to upregulation of receptors on the cell surface as a result of granule mobilisation. Since LAM-primed neutrophils released 65% of the cell content of gelatinase but showed no increased release of vitamin B(12)-binding protein, mobilisation of the gelatinase granules rather than the specific granules is concluded to be responsible for the priming effects. This is in agreement with the subcellular localisation of receptors for fMLF, WKYMVm, as well as galectin-3, which are stored in the secretory vesicles and gelatinase granules. The priming effect appeared very similar to that of Escherichia coli lipopolysaccharide, and since no differences in activity could be detected between AraLAM and ManLAM, we hypothesize that the lipid anchor of the LAM is responsible for the priming effects.
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| 33. |
- Fäldt, Jenny, 1971, et al.
(author)
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The phagocyte chemiluminescence paradox: luminol can act as an inhibitor of neutrophil NADPH-oxidase activity.
- 1999
-
In: Luminescence : the journal of biological and chemical luminescence. - 1522-7235. ; 14:3, s. 153-60
-
Journal article (peer-reviewed)abstract
- The chemiluminescence system amplified by luminol or isoluminol is a sensitive and widely used method for determination of respiratory burst products generated by the NADPH-oxidase in phagocytes. The present study shows that luminol, but not isoluminol, can inhibit the release of oxygen metabolites generated by human neutrophil NADPH-oxidase. The difference in structure between luminol and isoluminol (rendering luminol more lipophilic than isoluminol, and thereby membrane-permeable), is suggested to determine indirectly whether or not the molecule is inhibitory. Luminol was shown to have an increased inhibitory effect after preincubation of neutrophils on a surface of aggregated IgG, suggesting that the cells can be transferred from a 'luminol-insensitive' to a 'luminol-sensitive' state. Since luminol had no inhibitory effect in a cell-free NADPH-oxidase system, it is likely that it interferes with the signal transduction pathway, leading to assembly and/or activation of the oxidase. As a consequence of the present results, showing that luminol but not isoluminol can inhibit NADPH-oxidase activity, we suggest that isoluminol is used in future studies of superoxide anion release from phagocytes.
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| 34. |
- Georgoudaki, Anna-Maria, et al.
(author)
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Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
- 2016
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 15:9, s. 2000-2011
-
Journal article (peer-reviewed)abstract
- Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells present in the tumor microenvironment (TME). Here, they contribute to immunosuppression, enabling the establishment and persistence of solid tumors as well as metastatic dissemination. We have found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome. An anti-MARCO monoclonal antibody was developed, which induces anti-tumor activity in breast and colon carcinoma, as well as in melanoma models through reprogramming-TAM-populations to a pro-inflammatory phenotype and increasing tumor immunogenicity. This anti-tumor activity is dependent on the inhibitory Fc-receptor, Fc gamma RIIB, and also enhances the efficacy of checkpoint therapy. These results demonstrate that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
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| 35. |
- Hagren Idevall, Karin, 1984-
(author)
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Språk och rasism : Privilegiering och diskriminering i offentlig, medierad interaktion
- 2016
-
Doctoral thesis (other academic/artistic)abstract
- This PhD thesis concerns language and racism. The aim is to explore how racism is reproduced in interaction in public debates on immigration, integration and refugee policy. From a constructivist pragmatic perspective, language is considered as a practice that composes and makes sense of our social world and all the phenomena and individuals that we perceive in it. Racist discourses discriminate against and privilege people by categorising them according to notions of cultural, ethnical, racial, religious and national differences.The thesis has two main themes: 1) the linguistic reproduction of, and response to, racist discrimination and privileging in interaction, and 2) the role of language in various public arenas, and the norms and conditions for participation in these arenas. The thesis comprises five studies. Study I examines racist discourses and conditions for participation in an online newspaper comments section. Study II examines how the phrase “politically correct” is used and negotiated in the same comments section, and how its usage leads to the reproduction and normalisation of racism. Another comments section is the focus of Study III, in which discriminating and privileging categorisations of Muslims, Islam, Swedes and Sweden are analysed. Study IV examines an anti-racist forum on the social networking site Instagram. In the study, the reproduction of norms of whiteness is analysed, as well as power relations that are evoked, sustained and transformed in interaction. Finally, Study V is an analysis of linguistic, visual and material reproductions of political positions and racist discourses in a debate among party leaders on Swedish television.The thesis demonstrates how normalisation of racism is accomplished in interaction, and how reproduction of hierarchically structured difference and bigoted stereotypes are performed, and challenged, through language. The medium, combined with the user’s speech acts, set up the norms and conditions for participation, and for the discursive processes that reproduce the relations and structures of power.
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| 36. |
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| 37. |
- Holmberg, Per, 1964, et al.
(author)
-
Funktionell grammatik och textanalys
- 2011
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In: Funktionell textanalys. - Stockholm : Norstedt. - 9789113032764 ; , s. 7-18
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Book chapter (other academic/artistic)
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| 38. |
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| 39. |
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| 40. |
- Holmberg, Per, 1964, et al.
(author)
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Grammatik med betydelse. En introduktion till funktionell grammatik
- 2006
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Book (other academic/artistic)abstract
- Funktionell grammatik är en grammatik som sätter språkets betydelse i fokus. Här ställs frågor som: Hur skapar och upprätthåller vi relationer med hjälp av språket? Hur använder vi språket för att förstå och beskriva våra erfarenheter? Hur utnyttjar vi grammatiken för att skapa flöden av information? Den funktionella grammatiken har rötter i den brittisk-australiske språkvetaren Michael Hallidays arbeten. Här presenteras modellen som helhet för första gången på svenska. Grammatiken illustreras genom ett stort urval exempel hämtade från olika sammanhang, bland annat sjukvårdsinformation på Internet, en ridlektion och ett panelsamtal i tv. Boken är främst avsedd för grundutbildningar i ämnet svenska, för såväl grammatisk analys som textanalys, men vänder sig också till forskare och språkarbetare av olika slag.
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| 41. |
- Håkansson, David, 1978-, et al.
(author)
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Språkvetenskapen i ett sammanhang
- 2017. - 1
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In: Varför språkvetenskap?. - Lund. - 9789144108902 ; , s. 13-17
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Book chapter (other academic/artistic)
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| 42. |
- Jansson, Gunilla, 1950-, et al.
(author)
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Skrift- och samtalspraktiker i äldreomsorgen : Rapport från projektet Omsorg som språkarbete. Hinder och möjligheter med svenska som andraspråk i den nya arbetsordningen
- 2014
-
Reports (other academic/artistic)abstract
- Hur påverkas arbetet på arbetsplatser i äldreomsorgen av ett ökat fokus på läsande och skrivande? Det är den övergripande frågeställningen i ett forskningsprojekt som bedrivits på tre äldreboenden under åren 2010-2011: Omsorg som språkarbete. Hinder och möjligheter med svenska som andraspråk i den nya arbetsordningen. I den här rapporten diskuteras de viktigaste slutsatserna från projektet, som består av två delstudier, en med fokus på skrift och en med fokus på samtalspraktiker. Språkforskarna Gunilla Jansson, Anna-Malin Karlsson och Zoe Nikolaidou har undersökt hur texter och samtal fungerar som arbetsredskap i det dagliga omsorgsarbetet, som till stor del handlar om att anpassa omsorg och bemötande efter de specifika individernas behov. Författarna visar hur institutionens ramar och regelverk lätt kommer i konflikt med andra mer personliga aspekter av omsorgsarbetarens yrkeskunskap. I både samtalsstudien och skriftbruksstudien handlar det om hur standardisering och likformighet krockar med en önskan om att se till unika individer och personliga detaljer. I rapporten diskuteras de strategier som de anställda har utvecklat för att hantera de motstridiga krav som den muntliga och skriftliga kommunikationen med och om de boende för med sig. Rapporten uppmuntrar till fortsatt reflektion kring arbetsplatsens muntliga och skriftliga genrer och hur de kan stödja olika aspekter av yrkeskunskap. Varje kapitel avslutas med förslag på frågor som personalen kan arbeta vidare med utifrån de iakttagelser som gjorts i projektet.
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| 43. |
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| 44. |
- Johannsson, Gudmundur, 1960, et al.
(author)
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Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
- 2002
-
In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 87:5, s. 2046-52
-
Journal article (peer-reviewed)abstract
- Thirty-eight women, aged 25-65 yr, with androgen deficiency due to hypopituitarism were treated with oral dehydroepiandrosterone (DHEA; 30 mg/d if <45 yr of age and 20 mg if > or =45 yr of age) for 6 months in a randomized, placebo-controlled, double blind study, followed by a 6-month open treatment period. The administration of DHEA raised the serum levels of DHEAS to normal age-related reference ranges and increased androstenedione and T to subnormal levels. Androgen effects on skin and/or pubic and/or axillary hair were observed in 84% (32 of 38) of the women after all received 6 months of DHEA treatment. No such effects were observed after the placebo treatment. These effects after 6 months were correlated with the serum levels of DHEAS (r = 0.37; P = 0.03), androstenedione (r = 0.42; P = 0.01), and T (r = 0.37; P = 0.03). The percentages of partners who reported improved alertness, stamina, and initiative by their spouses were 70%, 64%, and 55%, respectively, in the DHEA group and 11%, 6%, and 11%, respectively, in the placebo group (P < 0.05). According to the partners, sexual relations tended to improve compared with placebo (P = 0.06). After 6 months of treatment, increased sexual interest or activity was reported by 50% of the women taking 30 mg DHEA, by none taking 20 mg DHEA, and by two women taking placebo (P = NS). Compared with levels after placebo administration, high density lipoprotein cholesterol and apolipoprotein A-1 levels decreased after DHEA. Serum concentrations of IGF-I, serum markers of bone metabolism, and bone density did not change. In conclusion, oral administration of a low dose of DHEA to adult hypopituitary women induced androgen effects on skin and axillary and pubic hair as well as changes in behavior, with only minor effects on metabolism.
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| 45. |
- Johansson, Sara, et al.
(author)
-
Digital production innovation projects – The applicability of managerial controls under high levels of complexity and uncertainty
- 2020
-
In: Journal of Manufacturing Technology Management. - : Emerald Group Publishing Ltd.. - 1741-038X .- 1758-7786.
-
Journal article (peer-reviewed)abstract
- Purpose: The purpose of the present study is to assist academics and practitioners in supporting and managing digital production innovation projects using managerial controls. The focus is on projects that deliver innovations containing new combinations of physical, digital and/or cyber-physical components, developed to be used within a production system. More specifically, this paper aims to explore the applicability of different managerial controls for managing and supporting digital production innovation projects, i.e. projects that are characterized by high levels of complexity and uncertainty. Design/methodology/approach: This is a multiple-case study in which interview data was collected from five digital production innovation projects in two manufacturing firms. The empirical data was used to analyze success factors, challenges and obstacles in different phases of the studied projects, and to connect these to the application of different types of managerial controls. Findings: The findings provide an increased understanding of who to control, what to control and how to control in digital production innovation projects. Research limitations/implications: This paper is focused specifically on the perception of managerial controls in digital production innovation projects and has not explicitly focused on manufacturing companies' intended usage of managerial controls. This paper's focus on manufacturing companies with producing customers and on projects developing solutions for their respective customers' production systems also encourages further studies at other companies undergoing a comparable transition. Given the necessary system perspective on managerial controls that is being highlighted, this paper emphasizes further research needs on how firms can also apply managerial controls to support external collaborations. Practical implications: The results have a number of managerial implications regarding digital production innovation projects. The most prominent findings revealed the importance of giving attention to the managerial controls related to the decision-making process and the involvement from stakeholders outside the organization itself. In particular, it was shown that managerial controls securing a more holistic involvement in the decision-making process should be applied, and that managerial controls suitable for customers and partners need to be developed. Originality/value: The study is among the first studies to focus on the application and perceived effectiveness of managerial controls in digital production innovation projects. The ways in which managerial controls are applied to collaborations with customers and partners and the ways in which action, cultural and personnel controls are combined and aligned to support the corporate decision-making process particularly stand out as essential for manufacturing companies' Industry 4.0 transition.
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| 46. |
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| 47. |
- Karalexi, Maria, et al.
(author)
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Perinatal mental health : how nordic data sources have contributed to existing evidence and future avenues to explore
- 2022
-
In: Nordic Journal of Psychiatry. - : Taylor & Francis Group. - 0803-9488 .- 1502-4725. ; 76:6, s. 423-432
-
Research review (peer-reviewed)abstract
- Purpose Perinatal mental health disorders affect a significant number of women with debilitating and potentially life-threatening consequences. Researchers in Nordic countries have access to high quality, population-based data sources and the possibility to link data, and are thus uniquely positioned to fill current evidence gaps. We aimed to review how Nordic studies have contributed to existing evidence on perinatal mental health.Methods We summarized examples of published evidence on perinatal mental health derived from large population-based longitudinal and register-based data from Denmark, Finland, Iceland, Norway and Sweden.Results Nordic datasets, such as the Danish National Birth Cohort, the FinnBrain Birth Cohort Study, the Icelandic SAGA cohort, the Norwegian MoBa and ABC studies, as well as the Swedish BASIC and Mom2B studies facilitate the study of prevalence of perinatal mental disorders, and further provide opportunity to prospectively test etiological hypotheses, yielding comprehensive suggestions about the underlying causal mechanisms. The large sample size, extensive follow-up, multiple measurement points, large geographic coverage, biological sampling and the possibility to link data to national registries renders them unique. The use of novel approaches, such as the digital phenotyping data in the novel application-based Mom2B cohort recording even voice qualities and digital phenotyping, or the Danish study design paralleling a natural experiment are considered strengths of such research.Conclusions Nordic data sources have contributed substantially to the existing evidence, and can guide future work focused on the study of background, genetic and environmental factors to ultimately define vulnerable groups at risk for psychiatric disorders following childbirth.
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| 48. |
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| 49. |
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| 50. |
- Karlsson, Anna-Malin, 1969-
(author)
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Alla kan inte ta en bensträckare
- 2014
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In: Svenska Dabladet. - Stockholm. - 2001-3868. ; :25/5
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Journal article (pop. science, debate, etc.)
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