SwePub - search: WFRF:(Karlsson Louise)

Enumeration	Reference	Cover	Find
1.	Andersson, Niklas, 1970, et al. (author) Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men 2009 In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 33:5, s. 525-533 Journal article (peer-reviewed)abstract Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteoporosis and obesity determinants (GOOD) study is a population-based cross-sectional study of 18-20 year-old men (n = 1068), from Gothenburg, Sweden. Major findings were confirmed in elderly men (n = 3014) from the Swedish part of the osteoporotic fractures in men (MrOS) multicenter population-based study. Main Outcome Measure: The genotype distributions and their association with body fat mass in different compartments, measured with dual-energy X-ray absorptiometry (DXA). Results: Out of 15 investigated SNPs in the IL-1 receptor antagonist (IL1RN) gene, a recently identified 30 untranslated region C4T (rs4252041, minor allele frequency 4%) SNP was associated with the primary outcome total fat mass (P = 0.003) and regional fat masses, but not with lean body mass or serum IL-1 receptor 1 (IL1RN) levels. This SNP was also associated with body fat when correcting the earlier reported IL1RN_2018 T4C (rs419598) SNP (in linkage disequilibrium with a well-studied variable number tandem repeat of 86 bp). The association between rs4252041 SNP and body fat was confirmed in the older MrOS population (P = 0.03). The rs4252041 SNP was part of three haplotypes consisting of five adjacent SNPs that were identified by a sliding window approach. These haplotypes had a highly significant global association with total body fat (P < 0.001). None of the other investigated members of the IL-1 gene family displayed any SNPs that have not been described previously to be significantly associated with body fat. Conclusions: The IL1RN gene, shown to enhance obesity by suppressing IL-1 effects in experimental animals, have no previously described gene polymorphisms and haplotypes that are associated with fat, but not lean mass in two populations of men. International Journal of Obesity (2009) 33, 525-533; doi: 10.1038/ijo.2009.47; published online 17 March 2009
2.	Andersson, Niklas, 1970, et al. (author) A variant near the interleukin-6 gene is associated with fat mass in Caucasian men 2010 In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 34:6, s. 1011-9 Journal article (peer-reviewed)abstract CONTEXT: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. OBJECTIVE: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these genes can be associated with obesity. DESIGN AND STUDY SUBJECTS: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-year-old men (n=1049), from the Gothenburg area (Sweden). Major findings were confirmed in two additional cohorts consisting of elderly men from the Osteoporotic Fractures in Men (MrOS) Sweden (n=2851) and MrOS US (n=5611) multicenter population-based studies. MAIN OUTCOME: The genotype distributions and their association with fat mass in different compartments, measured with dual-energy X-ray absorptiometry. RESULTS: Out of 18 evaluated tag SNPs near the IL6 and IL6R genes, a recently identified SNP rs10242595 G/A (minor allele frequency=29%) 3' of the IL6 gene was negatively associated with the primary outcome total body fat mass (effect size -0.11 standard deviation (s.d.) units per A allele, P=0.02). This negative association with fat mass was also confirmed in the combined MrOS Sweden and MrOS US cohorts (effect size -0.05 s.d. units per A allele, P=0.002). When all three cohorts were combined (n=8927, Caucasian subjects), rs10242595()A showed a negative association with total body fat mass (effect size -0.05 s.d. units per A allele, P<0.0002). Furthermore, the rs10242595()A was associated with low body mass index (effect size -0.03, P<0.001) and smaller regional fat masses. None of the other SNPs investigated in the GOOD study were reproducibly associated with body fat. CONCLUSIONS: The IL6 gene polymorphism rs10242595(*)A is associated with decreased fat mass in three combined cohorts of 8927 Caucasian men.
3.	Bringselius, Louise, et al. (author) Särskilda förutsättningar vid enmyndighetsreformer i staten 2012 In: Speglingar av en förvaltning i förändring : reformeringen av försäkringskassan. - 9789173590570 Book chapter (other academic/artistic)
4.	Caesar, Ulla, 1964, et al. (author) Delayed and cancelled orthopaedic surgery; are there solutions to reduce the complex set of problems? A systematic literature review. 2021 In: International journal of clinical practice. - : Hindawi Limited. - 1742-1241 .- 1368-5031. ; 75:9 Journal article (peer-reviewed)abstract Unexpected cancellations of, and delays to, orthopaedic surgery have adverse effects, with a negative impact on hospital performance and undesirable patient outcomes. As cancellations and delays are common, finding measures to prevent them is a matter of urgency.The present systematic review conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and the Cochrane Handbook. Peer-reviewed studies reporting on cancellations or delays in patients requiring emergency orthopaedic or planned orthopaedic surgery that compared care action/intervention with no action or traditional care were included. The Grading of Recommendations Assessment, Development and Evaluation used to assess the quality of evidence of the results from the included studies. The objective of the present study was systematically to search and review the literature for qualitative evidence of factors that might reduce cancellations of and delays to orthopaedic surgical procedures.The electronic search yielded 1209 studies and eight articles were included in the performed quality assessment. The heterogeneity of the studies and the lack of calculations and statistics in the studies resulted in no meta-analysis. The result of the quality assessment indicated that the evidence ranked from low to very low across the different outcomes. The main limiting factor, which was the reason for a decrease in quality in some outcomes, was the study designs, which were non-randomised control or retrospective approach. The interventions in the included studies could help to support a reduction in the risk of cancelled and delayed orthopaedic procedures.This systematic literature review has revealed important evidence to help reduce the risk of cancelled and delayed orthopaedic procedures associated with a variety of care action exposures. They include a fast-track pathway, pre-operative guidelines and telephone contact with patients prior to surgery, as well as careful consideration of additional pre-operative tests.
5.	Ljunggren, Stefan, et al. (author) Biomonitoring of Metal Exposure During Additive Manufacturing (3D Printing) 2019 In: SH@W Safety and Health at Work. - : Elsevier. - 2093-7911 .- 2093-7997. ; 10:4, s. 518-526 Journal article (peer-reviewed)abstract Background: Additive manufacturing (AM) is a rapidly expanding new technology involving challenges to occupational health. Here, metal exposure in an AM facility with large-scale metallic component production was investigated during two consecutive years with preventive actions in between.Methods: Gravimetric analyzes measured airborne particle concentrations, and filters were analyzed for metal content. In addition, concentrations of airborne particles <300 nm were investigated. Particles from recycled powder were characterized. Biomonitoring of urine and dermal contamination among AM operators, office personnel, and welders was performed.Results: Total and inhalable dust levels were almost all below occupational exposure limits, but inductively coupled plasma mass spectrometry showed that AM operators had a significant increase in cobalt exposure compared with welders. Airborne particle concentrations (<300 nm) showed transient peaks in the AM facility but were lower than those of the welding facility. Particle characterization of recycled powder showed fragmentation and condensates enriched in volatile metals. Biomonitoring showed a nonsignificant increase in the level of metals in urine in AM operators. Dermal cobalt and a trend for increasing urine metals during Workweek Year 1, but not in Year 2, indicated reduced exposure after preventive actions.Conclusion: Gravimetric analyses showed low total and inhalable dust exposure in AM operators. However, transient emission of smaller particles constitutes exposure risks. Preventive actions implemented by the company reduced the workers' metal exposure despite unchanged emissions of particles, indicating a need for careful design and regulation of the AM environments. It also emphasizes the need for relevant exposure markers and biomonitoring of health risks.
6.	Snaebjörnsson, Thorkell, 1982, et al. (author) Graft Diameter and Graft Type as Predictors of Anterior Cruciate Ligament Revision: A Cohort Study Including 18,425 Patients from the Swedish and Norwegian National Knee Ligament Registries 2019 In: The Journal of bone and joint surgery. American volume. - 1535-1386. ; 101:20, s. 1812-1820 Journal article (peer-reviewed)abstract BACKGROUND: It is important to investigate and compare graft diameters as well as graft types to identify risk factors for revision after an anterior cruciate ligament (ACL) reconstruction. We performed the current study in order to analyze the early ACL revision rate among patients treated with hamstring tendon (HT) autografts or patellar tendon (PT) autografts of different diameters. Our hypothesis was that an increase in both HT and PT autograft diameters would reduce the risk of early ACL revision. METHODS: This retrospective study was based on prospectively collected data from the national knee ligament registries of Norway and Sweden and included patients who underwent primary ACL reconstruction during the period of 2004 through 2014. The primary end point was the 2-year incidence of ACL revision. The impact of graft type and diameter on the incidence of revision surgery was reported as relative risks (RRs) with 95% confidence intervals (CIs), estimated by using generalized linear models with a binomial distribution and log-link function. RESULTS: Of 58,692 patients identified, a total of 18,425 patients were included in this study. The 2-year rate of ACL revision was 2.10% (PT autografts, 2.63%; HT autografts, 2.08%; RR = 0.93 [95% CI = 0.60 to 1.45]). There was an increased risk of ACL revision among patients treated with HT autografts with a diameter of <8 mm compared with larger HT autografts (RR = 1.25 [95% CI = 1.01 to 1.57]). Patients treated with HT autografts with a diameter of ≥9.0 mm or ≥10.0 mm had a reduced risk of early ACL revision compared with patients treated with PT autografts. CONCLUSIONS: Patients treated with larger-diameter HT autografts had a lower risk of early ACL revision compared with those treated with HT autografts of <8 mm. Patients treated with HT autografts of ≥9 or ≥10 mm had a reduced risk of early ACL revision compared with patients treated with PT autografts. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
7.	Spurdle, Amanda B., et al. (author) Common Genetic Variation at BARD1 Is Not Associated with Breast Cancer Risk in BRCA1 or BRCA2 Mutation Carriers 2011 In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755 .- 1055-9965. ; 20:5, s. 1032-1038 Journal article (peer-reviewed)abstract Background: Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies. Methods: A cohort of 5,546 BRCA1 and 2,865 BRCA2 mutation carriers was used to evaluate risk of breast cancer associated with BARD1 Cys557Ser. In a second nonindependent cohort of 1,537 of BRCA1 and 839 BRCA2 mutation carriers, BARD1 haplotypes were also evaluated. Results: The BARD1 Cys557Ser variant was not significantly associated with risk of breast cancer from single SNP analysis, with a pooled effect estimate of 0.90 (95% CI: 0.71-1.15) in BRCA1 carriers and 0.87 (95% CI: 0.59-1.29) in BRCA2 carriers. Further analysis of haplotypes at BARD1 also revealed no evidence that additional common genetic variation not captured by Cys557Ser was associated with breast cancer risk. Conclusion: Evidence to date does not support a role for BARD1 variation, including the Cy557Ser variant, as a modifier of risk in BRCA1/2 mutation carriers. Impact: Interactors of BRCA1/2 have been implicated as modifiers of BRCA1/2-associated cancer risk. Our finding that BARD1 does not contribute to this risk modification may focus research on other genes that do modify BRCA1/2-associated cancer risk. Cancer Epidemiol Biomarkers Prev; 20(5); 1032-38. (C) 2011 AACR.
8.	Ståhle, Alexander, et al. (author) Designguide för Smarta gator 2022 Book (other academic/artistic)abstract Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
9.	Sundemo, David, et al. (author) Generalised joint hypermobility increases ACL injury risk and is associated with inferior outcome after ACL reconstruction: A systematic review 2019 In: BMJ Open Sport and Exercise Medicine. - : BMJ. - 2055-7647. ; 5:1 Research review (peer-reviewed)abstract Objectives To investigate the association between generalised joint hypermobility (GJH) and ACL injury risk. Secondary aims involved evaluating associations between GJH and postoperative outcome (including graft-failure risk, knee laxity and patient-reported outcome). Furthermore, we aimed to compare the performance of different grafts in patients with GJH. Methods Databases MEDLINE/PubMed, EMBASE and the Cochrane Library were searched, including 2760 studies. Two reviewers independently screened studies for eligibility. A modified version of the MINORS score was applied for quality appraisal. Studies assessing GJH while reporting the risk of ACL injury and/or postoperative outcome were included. Results Twenty studies were included, using several different methods to determine GJH. There was consistent evidence showing that GJH is a risk factor for unilateral ACL injury in males, while in females, the results were conflicting. There was limited evidence associating GJH with increased knee laxity 5 years postoperatively. There was consistent evidence of inferior postoperative patient-reported outcome in patients with GJH. Moreover, there was limited yet consistent evidence indicating that patellar-tendon autografts are superior to hamstring-tendon autografts in patients with GJH in terms of knee laxity and patient-reported outcome. There was insufficient evidence to draw conclusions regarding the outcomes of bilateral ACL injury and graft failure. Conclusions In men, GJH was associated with an increased risk of unilateral ACL injury. Moreover, GJH was associated with greater postoperative knee laxity and inferior patient-reported outcome. Based on the available evidence, a patellar-tendon autograft appears to be superior to a hamstring-tendon autograft in patients with GJH. However, the included studies were heterogeneous and there is a need for consensus in the assessment of GJH within sports medicine. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
10.	Abrahamsen Grøndahl, Vigdis, 1964-, et al. (author) A pattern approach to analysing patients’ satisfaction and quality of care perceptions in hospital 2011 In: The International Journal of Person Centered Medicine. - 2043-7730 .- 2043-7749. ; 1:4, s. 766-775 Journal article (peer-reviewed)
11.	Abrahamsen Grøndahl, Vigdis, 1964-, et al. (author) Exploring patient satisfaction predictors in relation to a theoretical model 2013 In: International Journal of Health Care Quality Assurance. - : Emerald Group Publishing Limited. - 0952-6862 .- 1758-6542. ; 26:1, s. 37-54 Journal article (peer-reviewed)abstract The aim is to describe patients' care quality perceptions and satisfaction and to explore potential patient satisfaction predictors as person‐related conditions, external objective care conditions and patients' perception of actual care received (“PR”) in relation to a theoretical model.Design/methodology/approachA cross‐sectional design was used. Data were collected using one questionnaire combining questions from four instruments: Quality from patients' perspective; Sense of coherence; Big five personality trait; and Emotional stress reaction questionnaire (ESRQ), together with questions from previous research. In total, 528 patients (83.7 per cent response rate) from eight medical, three surgical and one medical/surgical ward in five Norwegian hospitals participated. Answers from 373 respondents with complete ESRQ questionnaires were analysed. Sequential multiple regression analysis with ESRQ as dependent variable was run in three steps: person‐related conditions, external objective care conditions, and PR (p < 0.05).FindingsStep 1 (person‐related conditions) explained 51.7 per cent of the ESRQ variance. Step 2 (external objective care conditions) explained an additional 2.4 per cent. Step 3 (PR) gave no significant additional explanation (0.05 per cent). Steps 1 and 2 contributed statistical significance to the model. Patients rated both quality‐of‐care and satisfaction highly.Originality/valueThe paper shows that the theoretical model using an emotion‐oriented approach to assess patient satisfaction can explain 54 per cent of patient satisfaction in a statistically significant manner.
12.	Abrahamsen Grøndahl, Vigdis, 1964-, et al. (author) Patients' experiences of care quality and satisfaction satisfaction during hospital stay : a qualitative study 2013 In: European Journal for Person Centered Healthcare. - : University of Buckingham Press. - 2052-5656 .- 2052-5648. ; 1:1, s. 185-192 Journal article (peer-reviewed)abstract Rationale, aim and objectives: Patients experiencing high care quality and satisfied patients are more likely to follow treatments. Patient satisfaction is an important contributor to physical and mental health-related quality of life. Research emphasises the need to further study satisfaction from the patients’ perspective. The aim was to describe patients’ experiences of care quality and the relation to their satisfaction during hospital stay. Methods: A qualitative descriptive design was used. Interviews were conducted with 22 patients discharged from hospital. Data was analysed by conventional content analysis.Results: Four categories and seven subcategories describing patients’ experiences of care quality and the relation to their satisfaction emerged. Desire to regain health comprised waiting for treatment, being cured, having hopes of being cured and described the treatment and health outcome of hospitalisation. Need to be met in a professional way as a unique person comprised receiving personalized knowledge, receiving healthcare by competent healthcare personnel and described the way patients need to be met by healthcare personnel. Need to be involved comprised taking responsibility for own health, leaving responsibility for own health and concerned the patients’ way of handling hospitalisation. Need to have balance between privacy and companionship concerned the relationship to fellow patients. Conclusions: Health condition is of great importance to patients’ experiences of quality of care and their satisfaction in relation to hospital stay. The healthcare personnel need to be aware that seriously ill patients may never be completely satisfied. Furthermore, healthcare personnel must do their utmost to provide the patients with person-centered care. Hospital managers must consider the design of wards with respect to such matters as multiple-bed versus single-bed rooms and heads of nursing must carefully plan each patient’s accommodation.
13.	Abrahamsen Grøndahl, Vigdis, 1964- (author) Patients’ perceptions of actual care conditions and patient satisfaction with care quality in hospital 2012 Doctoral thesis (other academic/artistic)abstract There are theoretical and methodological difficulties in measuring the concepts of quality of care and patient satisfaction, and the conditions associated with these concepts. A theoretical framework of patient satisfaction and a theoretical model of quality of care have been used as the theoretical basis in this thesis. Aim. The overall aim was to describe and explore relationships between person-related conditions, external objective care conditions, patients’ perceptions of quality of care, and patient satisfaction with care in hospital. Methods. Quantitative and qualitative methods were used. In the quantitative study (I-III), 528 patients (83.7%) from eight medical, three surgical and one mixed medical/surgical ward in five hospitals in Norway agreed to participate (10% of total discharges). Data collection was conducted using a questionnaire comprising four instruments: Quality from Patients’ Perspective (QPP); Sense of Coherence scale (SOC); Big Five personality traits – the Single-Item Measures of Personality (SIMP); and Emotional Stress Reaction Questionnaire (ESRQ). In addition, questions regarding socio-demographic data and health conditions were asked, and data from ward statistics were included. Multivariate statistical analysis was carried out (I-III). In the qualitative study 22 informants were interviewed (IV). The interviews were analysed by conventional content analysis. Main findings. Patients’ perceptions of quality of care and patient satisfaction ranged from lower to higher depending on whether all patients or groups of patients were studied. The combination of person-related and external objective care conditions explained 55% of patients’ perceptions of quality of care (I). 54.7% of the variance in patient satisfaction was explained, and the person-related conditions had the strongest impact, explaining 51.7% (II). Three clusters of patients were identified regarding their scores on patient satisfaction and patients’ perceptions of quality of care (III). One group consisted of patients who were most satisfied and had the best perceptions of quality of care, a second group of patients who were less satisfied and had better perceptions, and a third group of patients who were less satisfied and had the worst perceptions. The qualitative study revealed four categories of importance for patients’ satisfaction: desire to regain health, need to be met in a professional way as a unique person, perspective on life, and need to have balance between privacy and companionship (IV). Conclusions. Patients’ perceptions of quality of care and patient satisfaction are two different concepts. The person-related conditions seem to be the strongest predictors of patients’ perceptions of quality of care and patient satisfaction. Registered nurses need to be aware of this when planning and conducting nursing care. There is a need of guidelines for handling over‑occupancy, and of procedures for emergency admissions on the wards. The number of registered nurses on the wards needs to be considered. Healthcare personnel must do their utmost to provide the patients with person‑centred care.
14.	Abrahamsen Grøndahl, Vigdis, et al. (author) Predictors of patients' satisfaction - basis for quality improvement work in hospital 2010 Conference paper (peer-reviewed)
15.	Abrahamsen Grøndahl, Vigdis, 1964-, et al. (author) Quality of care from patients' perspective : impact of the combination of person-related and external objective care conditions 2011 In: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 20:17/18, s. 2540-2551 Journal article (peer-reviewed)abstract Aims and objectives. To describe patients' perceptions of quality of care and to explore combinations of person-related and external objective care conditions as potential predictors of these perceptions. Background. Several studies have examined various single factors of person-related and external objective care conditions in relation to quality of care. None of these has included the effect of over-occupancy on patients' perception of quality of care. Furthermore, little is known about how combinations of different factors are related to each other and to the perception of quality of care using multivariate analysis. Design. A cross-sectional design. Method. A total of 528 patients (83·7%) from 12 medical, surgical or medical-surgical wards in five hospitals in Norway participated. Perceptions of quality of care and person-related conditions were measured with the 'Quality from Patient's Perspective' instrument. Data on external objective care conditions was collected from ward statistics provided by head nurses. Multivariate general linear modelling was used ( p < 0·05). Results. The combination of person-related and external objective care conditions revealed five factors that predict patients' perception of quality of care. Three of these are person-related conditions: sex, age and self-reported psychological well-being and two of them are external objective care conditions: RNs (headcount) on the wards and frequency of over-occupancy. These five factors explained 55% of the model. Patients rated the quality of care high. Conclusions. Sex, age, psychological well-being, frequency of over-occupancy and the number of RNs are important factors that must be emphasised if patients are to perceive the quality of care as high. Relevance to clinical practice. Head nurses and healthcare authorities must continually prepare the wards for over-occupancy and they must consider the number of RNs working on the wards.
16.	Abrahamsen Grøndahl, Vigdis, 1964-, et al. (author) Quality of care from patient's perspective - how is it affected by the hospital's organisation and structure of nursing care? 2009 Conference paper (peer-reviewed)
17.	Amiri, Shahnaz, 1962- (author) Economic and Environmental Benefits of CHP-based District Heating Systems in Sweden 2013 Doctoral thesis (other academic/artistic)abstract Future energy systems and thus the climate are affected by many factors, such as energy resources, energy demand, energy policy and the choice of energy technologies. Energy systems of the future are facing three main challenges; the steady growth of global energy demand, the energy resource depletion, as well as the increasing emissions of carbon dioxide (CO2) and other greenhouse gases and their impact on climate change. To meet the mentioned challenges with sustainability in mind, actions that increase energy efficiency and choosing an energy-efficient energy system which is cost efficient will be essential. Combined heat and power (CHP) plants and district heating and cooling could contribute greatly to increased system efficiency by using energy otherwise wasted.The aim of this study is to increase the understanding of how CHP-based district heating and cooling systems using different primary energy sources can contribute to more cost-efficient energy systems, which reduce global CO2 emissions, and to highlight the impact of some important parameters and measures on Swedish municipal district heating systems. An important assumption in this study is the estimation of CO2 emissions from electricity production, which is based on marginal electricity perspectives. In the short term, the marginal electricity is assumed to come from coal-fired condensing power plants while in the long term it consists of electricity produced by natural gas-fired combined cycle condensing power plants. This means that the local electricity production will replace the marginal electricity production. The underlying assumption is an ideal fully deregulated European electricity market where trade barriers are removed and there are no restrictions on transfer capacity.The results show that electricity generation in CHP plants, particularly in higher efficiency combined steam and gas turbine heat and power plants using natural gas, can reduce the global environmental impact of energy usage to a great extent. The results confirm, through the scenarios presented in this study, that waste as a fuel in CHP-based district heating systems is fully utilised since it has the lowest operational costs. The results also show how implementation of a biogas-based CHP plant in a biogas system contributes to an efficient system, as well as lowering both CO2 emissions and system costs. The results show that replacing electricity-driven (e.g. compression) cooling by heat-driven cooling using district heating (e.g. absorption chillers) in a CHP system is a cost-effective and climate friendly technology as electricity consumption is reduced while at the same time the electricity generation will be increased. The results of the study also show that there is potential to expand district heating systems to areas with lower heat density, with both environmental and economic benefits for the district heating companies.The results reveal that the operation of a studied CHP-based district heating system with an imposed emission limit is very sensitive to the way CO2 emissions are accounted, i.e., local CO2 emissions or emissions from marginal electricity production. The results show how the electricity production increases in the marginal case compared with the local one in order to reduce global CO2 emissions. The results also revealed that not only electricity and fuel prices but also policy instruments are important factors in promoting CHP-based district heating and cooling systems. The use of electricity certificates has a large influence for the introduction of biogas-based cogeneration. Another conclusion from the modelling is that present Swedish policy instruments are strong incentives for cogeneration with similar impact as applying external costs.
18.	Ander, Malin, 1983-, et al. (author) U-CARE: UngaKan : Ett internet-administrerat guidat självhjälsprogram för unga som diagnosticerats med cancer under tonåren 2017 Other publication (pop. science, debate, etc.)
19.	Andersson, Annica, 1983, et al. (author) Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis 2015 In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354. ; 17:32 Journal article (peer-reviewed)abstract Introduction: The incidence and progression of many autoimmune diseases are sex-biased, which might be explained by the immunomodulating properties of endocrine hormones. Treatment with estradiol potently inhibits experimental autoimmune arthritis. Interleukin-17-producing T helper cells (Th17) are key players in several autoimmune diseases, particularly in rheumatoid arthritis. The aim of this study was to investigate the effects of estrogen on Th17 cells in experimental arthritis. Methods: Ovariectomized DBA/1 mice treated with 17 beta-estradiol (E2) or placebo were subjected to collagen-induced arthritis (CIA), and arthritis development was assessed. Th17 cells in joints and lymph nodes were studied by flow cytometry. Lymph node Th17 cells were also examined in ovariectomized estrogen receptor a-knockout mice (ERa-/-) and wild-type littermates, treated with E2 or placebo and subjected to antigen-induced arthritis. Results: E2-treated mice with established CIA showed reduced severity of arthritis and fewer Th17 cells in joints compared with controls. Interestingly, E2-treated mice displayed increased Th17 cells in lymph nodes during the early phase of the disease, dependent on ER alpha. E2 increased the expression of C-C chemokine receptor 6 (CCR6) on lymph node Th17 cells as well as the expression of the corresponding C-C chemokine ligand 20 (CCL20) within lymph nodes. Conclusions: This is the first study in which the effects of E2 on Th17 cells have been characterized in experimental autoimmune arthritis. We report that E2 treatment results in an increase of Th17 cells in lymph nodes during the early phase of arthritis development, but leads to a decrease of Th17 in joints during established arthritis. Our data suggest that this may be caused by interference with the CCR6-CCL20 pathway, which is important for Th17 cell migration. This study contributes to the understanding of the role of estrogen in the development of autoimmune arthritis and opens up new fields for research concerning the sex bias in autoimmune disease.
20.	Andersson, Annica, 1983, et al. (author) Suppression of Experimental Arthritis and Associated Bone Loss by a Tissue-Selective Estrogen Complex. 2016 In: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 157:3, s. 1013-20 Journal article (peer-reviewed)abstract In addition to the systemic inflammation present in rheumatoid arthritis (RA), decreased estradiol levels in postmenopausal RA patients further accelerate bone loss in these patients. The tissue-selective estrogen complex (TSEC), an estrogen combined with a selective estrogen receptor modulator, is a new hormone replacement therapy option. The first approved TSEC, containing conjugated estrogens and bazedoxifene (BZA), reduces menopausal symptoms and prevents osteoporosis with an improved safety profile compared with conventional hormone replacement therapy. Previous studies have shown that estrogens strongly inhibit experimental arthritis whereas BZA is mildly suppressive. In this study the antiarthritic potential of combined BZA and estradiol is explored for the first time. Female ovariectomized DBA/1 mice were subjected to collagen-induced arthritis, an experimental postmenopausal RA model, and treated with BZA, 17β-estradiol (E2), combined BZA and E2 (BZA/E2), or vehicle. BZA/E2 suppressed arthritis severity and frequency, synovitis, and joint destruction, equally efficient as E2 alone. Unwanted estrogenic proliferative effects on the endometrium were blocked by the addition of BZA, determined by collecting uterine weights. Bone mineral density was measured by peripheral quantitative computed tomography, and all treatments protected collagen-induced arthritis mice from both trabecular and cortical bone loss. Moreover, BZA/E2, but not E2 alone, inhibited preosteoclast formation and reduced serum anticollagen type II antibodies. In conclusion, a TSEC, herein combined BZA/E2, suppresses experimental arthritis and prevents associated bone loss as efficiently as E2 alone but with minimal uterine effects, highlighting the need for clinical trials that evaluate the addition of a TSEC to conventional postmenopausal RA treatment.
21.	Andersson, Fredrik, et al. (author) Organisatoriska vägval : en studie av Försäkringskassans förändringsarbete 2011 In: Nordiske organisasjonsstudier. - : Fagbokforlaget. - 1501-8237. ; 13:4, s. 53-76 Journal article (peer-reviewed)
22.	Andersson, Fredrik, et al. (author) Organisatoriska vägval -- En studie av Försäkringskassans förändringsarbete 2011 In: Nordiske Organisasjonsstudier. - 1501-8237. ; 13:4, s. 53-76 Journal article (peer-reviewed)abstract The Swedish Social Insurance Agency is an important part of the Swedish welfare state. The Agency has recently made a number of major changes, such as establishing a new internal organization and reforming processes for decision making. Many of these changes have been controversial. Critics have complained that the Agency shows a lack of efficiency, has failed to make payments on time, and has been too harsh in its application of eligibility rules. The changes have put the agency at a number of crossroads, many of them recurring from earlier reforms, in dealing with problems such as regional differences in the application of rules. In this article, some of these choices are discussed. The discussion departs from four dichotomies: uniformity-local adaptation; centralization-decentralization; specialization-generalist approaches; and closeness-distance. These dichotomies are illustrated with examples from the agency. The general conclusion is that although the change process has taken a rocky road, there has been a great deal of internal consistency in the combination of measures taken.
23.	Andersson, Fredrik, et al. (author) Speglingar av en förvaltning i förändring: Reformeringen av Försäkringskassan 2012 Book (other academic/artistic)abstract Svensk statsförvaltning genomgår, precis som privat sektor, ständigt förändringar och omstruktureringar, drivna av olika samhällstrender, ledarskapsidéer och politiska styrfilosofier. Vid dessa förändringar ställs verksamheten inför vägval som på olika sätt kan påverka dess förmåga att leva upp till omgivningens krav och förväntningar. Samtidigt finns inte utrymme för risktagande, eftersom förvaltningens agerande och beslut kan vara avgörande för individers försörjning och framtid. Det ställer stora krav på dessa myndigheter, som balanserar ekonomimål, demokratimål och rättssäkerhetsmål. Denna bok avser att spegla olika organisatoriska dilemman och utmaningar som myndigheter i svensk och internationell statsförvaltning kan möta. Detta sker med utgångspunkt i en studie av Försäkringskassans enmyndighetsreform år 2005 och dess förändringsarbete under åren därefter. Bokens författare kommer från tre olika ämnesområden: företagsekonomi, nationalekonomi och statsvetenskap. Samtliga är knutna till Lunds universitet och till forskningsprogrammet ”Från många till en?” (2008-2012). Programmet finansierades av Försäkringskassan, men genomfördes självständigt. Med boken hoppas författarna kunna öka förståelsen – och intresset - för frågor om organisation, styrning och ledning i en statsförvaltning i förändring.
24.	Andersson, Susanne, et al. (author) Attitudes Regarding Participation in a Diabetes Screening Test among an Assyrian Immigrant Population in Sweden 2016 In: Nursing Research and Practice. - : Hindawi Limited. - 2090-1429 .- 2090-1437. Journal article (peer-reviewed)abstract Immigrants from the Middle East have higher prevalence and incidence of type 2 diabetes (T2D) compared with native Swedes. The aim of the study was to describe and understand health beliefs in relation to T2D as well as attitudes regarding participation in a screening process in a local group of Assyrian immigrants living in Sweden. A qualitative and quantitative method was chosen in which 43 individuals participated in a health check-up and 13 agreed to be interviewed. Interviews were conducted, anthropometric measurements and blood tests were collected, and an oral glucose tolerance test was performed. In total, 13 of the 43 participants were diagnosed with impaired glucose metabolism, 4 of these 13 had TD2. The interviewed participants perceived that screening was an opportunity to discover more about their health and to care for themselves and their families. Nevertheless, they were not necessarily committed to taking action as a consequence of the screening. Instead, they professed that their health was not solely in their own hands and that they felt safe that God would provide for them. Assyrians' background and religion affect their health beliefs and willingness to participate in screening for TD2.
25.	Arendt, Maja Louise, et al. (author) The ABCC4 gene is associated with pyometra in golden retriever dogs 2021 In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11 Journal article (peer-reviewed)abstract Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between breeds (3-66%). The clear breed predisposition suggests that genetic risk factors are involved in disease development. To identify genetic risk factors associated with the disease, we performed a genome-wide association study (GWAS) in golden retrievers, a breed with increased risk of developing pyometra (risk ratio: 3.3). We applied a mixed model approach comparing 98 cases, and 96 healthy controls and identified an associated locus on chromosome 22 (p = 1.2 x 10(-6), passing Bonferroni corrected significance). This locus contained five significantly associated SNPs positioned within introns of the ATP-binding cassette transporter 4 (ABCC4) gene. This gene encodes a transmembrane transporter that is important for prostaglandin transport. Next generation sequencing and genotyping of cases and controls subsequently identified four missense SNPs within the ABCC4 gene. One missense SNP at chr22:45,893,198 (p.Met787Val) showed complete linkage disequilibrium with the associated GWAS SNPs suggesting a potential role in disease development. Another locus on chromosome 18 overlapping the TESMIN gene, is also potentially implicated in the development of the disease.
26.	Augustsson, Anna, et al. (author) Persistent hazardous waste and the quest towards a circular economy : the example of arsenic in Chromated Copper Arsenate-treated wood 2017 In: Journal of Industrial Ecology. - : Wiley-Blackwell. - 1088-1980 .- 1530-9290. ; 21:3, s. 689-699 Journal article (peer-reviewed)abstract The importance of a circular economy is today widely accepted and advocated, but among the challenges in achieving this, we find difficulties in the implementation of legislation and policies designed to control various waste streams from society. The example used in this article is wood that has been treated with chromated copper arsenate (CCA), which, in Sweden, has been covered by the rules for hazardous waste since 2002. One year later, in 2003, a survey showed that only 42% to 50% of the expected amount of CCA waste could be traced to the public waste management system. An updated material flow analysis for 2010 revealed that the figure had increased to 73%, whereas the fraction of correctly treated CCA wood waste had increased from 11% to 35%. However, almost one third of the expected volume was still not tracable, and half of the amount that was correctly submitted was incinerated together with nontoxic waste fractions. This results in, for example, arsenic contamination of slag and fly ashes that prevents the further use of these residue products. So, despite legislative instruments, there is still an urgent need for an improved collection of hazardous wood waste, as well as better routines for identifying hazardous flows and separating them from nonhazardous ones. For a circular economy to be achievable, a key priority should be to reduce the gap between intended directions and legislation, on one hand, and activities in practice on the other.
27.	Barmpatsalou, Vicky, et al. (author) Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs 2023 In: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 181 Journal article (peer-reviewed)abstract Colonic mucus plays a key role in colonic drug absorption. Mucus permeation assays could therefore provide useful insights and support rational formulation development in the early stages of drug development. However, the collection of native colonic mucus from animal sources is labor-intensive, does not yield amounts that allow for routine experimentation, and raises ethical concerns. In the present study, we developed an in vitro porcine artificial colonic mucus model based on the characterization of native colonic mucus. The structural properties of the artificial colonic mucus were validated against the native secretion for their ability to capture key diffusion patterns of macromolecules in native mucus. Moreover, the artificial colonic mucus could be stored under common laboratory conditions, without compromising its barrier properties. In conclusion, the porcine artificial colonic mucus model can be considered a biorelevant way to study the diffusion behavior of drug candidates in colonic mucus. It is a cost-efficient screening tool easily incorporated into the early stages of drug development and it contributes to the implementation of the 3Rs (refinement, reduction, and replacement of animals) in the drug development process.
28.	Bellander, Theres, 1977- (author) Ungdomars dagliga interaktion : En språkvetenskaplig studie av sex gymnasieungdomars bruk av tal, skrift och interaktionsmedier 2010 Doctoral thesis (other academic/artistic)abstract This thesis explores young people's interaction with different individuals through a variety of media. Three girls and three boys aged 16–18, from an urban school, a rural school and a suburban school, were each observed for a week, at school, at home and during leisure activities. The data analysed consist of field notes, video and audio recordings, and texts written by the participants. The aim of the study is to investigate how young people’s use of language varies in relation to different contexts. Questions are asked about what activities they participate in, what media they use and how they use them, and how they express themselves orally and in writing in different contexts and through different media. The study is based in sociolinguistic theory and activity type theory. Data were collected using ethnographical methods, and analytical tools were drawn from a broadly defined field of discourse analysis. The investigation sheds light on the relationship between what young people are doing socially in any given situation and how they interact. Variation in linguistic styles is made visible by a study of the same individuals involved in different communicative activities. Young people are shown to be a heterogeneous group who engage in different sets of activities. The study questions prevailing definitions and categorisations of adolescents’ linguistic styles and use of electronic media. The outcome is a complex description of everyday interaction, which is found to be shaped by the frames for communicative activities, the technical characteristics of the media employed, and individual factors. In conversational turns, Internet chat messages and text messages, young people select resources from their individual linguistic repertoires in order to achieve specific goals or construct particular roles through their interaction.
29.	Bergh, Anne-Louise, et al. (author) Nurses’ Patient Education Questionnaire : development and validation process 2015 In: Journal of Research in Nursing. - : Sage Publications Ltd.. - 1744-9871 .- 1744-988X. ; 20:3, s. 181-200 Journal article (peer-reviewed)abstract Abstract Conditions for nurses’ daily patient education work are unclear and require clarification. The aim was to develop and validate the Nurses’ Patient Education Questionnaire, a questionnaire that assesses nurses’ perceptions of appropriate conditions for patient education work: what nurses say they actually do and what they think about what they do. The questionnaire was developed from a literature review, resulting in the development of five domains. This was followed by ‘cognitive interviewing’ with 14 nurses and dialogue with 5 pedagogical experts. The five domains were identified as significant for assessing nurses’ beliefs and knowledge; education environment; health care organisation; interdisciplinary cooperation and collegial teamwork; and patient education activities. A content validity index was used for agreement of relevance and consensus of items by nurses (n¼10). The total number of items in the final questionnaire is 60, consisting of demographic items, what nurses report they do and perceptions about patient education in daily work. The questionnaire can be used by managers and nurses to identify possibilities and barriers to patient education in different care contexts.
30.	Bergh, Anne-Louise, et al. (author) Registered nurses' perceptions of conditions for patient education - focusing on aspects of competence 2014 In: Scandinavian Journal of Caring Sciences. - : Wiley. - 1471-6712 .- 0283-9318. ; 28:3, s. 523-536 Journal article (peer-reviewed)abstract Background: It is important to clarify nurses' perceptions of conditions for patient education in daily work as research findings are ambiguous. There is a gap between societal regulations on nurses' competence in accomplishment/achievement of patient education and research findings. Aim: The aim was to describe nurses' perceptions of conditions for patient education, focusing on aspects of competence. The aim was also to describe differences in conditions for nurses working in primary, municipal and hospital care. Methods: The study is a cross-sectional survey and is part of a project about nurses' patient-education. A randomized selection of nurses (842) received a questionnaire comprising 47 items concerning factual experience and attitudes to patient education and 13 background items. Questionnaires were returned by 83% of participants. Descriptive statistics, non-parametric tests and content analysis for open-ended items were used. Results: Nurses' perceptions of conditions for patient education differ between health-care settings. Primary care nurses are at an advantage in following research in patient education, perception of their own competence (prioritizing and knowing their mandate in patient teaching), pedagogical education and post graduate specializations. Conclusions: Nurses' patient education must be more visualized and appropriate conditions created at each workplace. In this change process, managers' support is considered vital.
31.	Bergh, Anne-Louise, et al. (author) Registered nurses' perceptions of conditions for patient education - focusing on organisational, environmental and professional cooperation aspects 2012 In: Journal of Nursing Management. - : Hindawi Limited. - 0966-0429 .- 1365-2834. ; 20:6, s. 758-770 Journal article (peer-reviewed)abstract Aim To describe nurses' perceptions of conditions for patient education, focusing on organisational, environmental and professional cooperation aspects, and to determine any differences between primary, municipal and hospital care. Background Although patient education is an important part of daily nursing practice, the conditions for this work are unclear and require clarification. Method A stratified random sample of 701 (83%) nurses working in primary, municipal and hospital care completed a 60-item questionnaire. The study is part of a larger project. The study items relating to organisation, environment and professional cooperation were analysed using descriptive statistics, non-parametric tests and content analysis. Results Conditions for patient education differ. Nurses in primary care had better conditions and more managerial support, for example in the allocation of undisturbed time. Conclusions Conditions related to organisation, environment and cooperation need to be developed further. In this process, managerial support is important, and nurses must ask for better conditions in order to carry through patient education. Implications for nursing management Managerial support for the development of visible patient education routines (e.g. allocation of time, place and guidelines) is required. One recommendation is to designate a person to oversee educational work.
32.	Bergren, Caroline, et al. (author) Equity in the neoliberalised Swedish university? 2017 Conference paper (peer-reviewed)
33.	Bernardi, Angelina I, et al. (author) Effects of lasofoxifene and bazedoxifene on B cell development and function. 2014 In: Immunity, inflammation and disease. - : Wiley. - 2050-4527. ; 2:4, s. 214-25 Journal article (peer-reviewed)abstract The third generation selective estrogen receptor modulators lasofoxifene (las) and bazedoxifene (bza) are indicated for treatment of postmenopausal osteoporosis. 17β-Estradiol (E2) and the second generation SERM raloxifene (ral) have major effects on the immune system, particularly on B cells. Treatment with E2 or ral inhibits B lymphopoiesis and treatment with E2, but not ral, stimulates antibody production. The effects of las and bza on the immune system have not been studied. Therefore, the aim of this study was to investigate their role in B cell development, maturation, and function. C57BL/6 mice were sham-operated or ovariectomized (ovx) and treated with vehicle, E2, ral, las, or bza. All substances increased total bone mineral density in ovx mice, as measured by peripheral quantitative computed tomography. In uterus, bza alone lacked agonistic effect in ovx mice and even acted as an antagonist in sham mice. As expected, E2 decreased B cell numbers at all developmental stages from pre-BI cells (in bone marrow) to transitional 1 (T1) B cells (in spleen) and increased marginal zone (MZ) B cells as determined by flow cytometry. However, treatment with las or bza only decreased the last stages of bone marrow B cell development and splenic T1 B cells, but had no effect MZ B cells. E2 increased antibody-producing cells quantified by ELISPOT, but las or bza did not. In conclusion, las and bza differ from E2 by retaining normal number of cells at most B cell stages during B lymphopoiesis and maturation and by not increasing antibody-producing cells.
34.	Bianchi, Matteo, et al. (author) Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort 2022 In: Arthritis & Rheumatology. - : John Wiley & Sons. - 2326-5191 .- 2326-5205. ; 74:2, s. 342-352 Journal article (peer-reviewed)abstract Objective Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to disease susceptibility and to identify novel avenues for research in IIMs.Methods Targeted DNA sequencing was used to mine coding and potentially regulatory single nucleotide variants from ~1,900 immune-related genes in a Scandinavian case–control cohort of 454 IIM patients and 1,024 healthy controls. Gene-based aggregate testing, together with rare variant– and gene-level enrichment analyses, was implemented to explore genotype–phenotype relations.Results Gene-based aggregate tests of all variants, including rare variants, identified IFI35 as a potential genetic risk locus for IIMs, suggesting a genetic signature of type I IFN pathway activation. Functional annotation of the IFI35 locus highlighted a regulatory network linked to the skeletal muscle–specific gene PTGES3L, as a potential candidate for IIM pathogenesis. Aggregate genetic associations with AGER and PSMB8 in the major histocompatibility complex locus were detected in the antisynthetase syndrome subgroup, which also showed a less marked genetic signature of the type I IFN pathway. Enrichment analyses indicated a burden of synonymous and noncoding rare variants in IIM patients, suggesting increased disease predisposition associated with these classes of rare variants.Conclusion Our study suggests the contribution of rare genetic variation to disease susceptibility in IIM and specific patient subgroups, and pinpoints genetic associations consistent with previous findings by gene expression profiling. These features highlight genetic profiles that are potentially relevant to disease pathogenesis.
35.	Blomberg, Oscar, et al. (author) Adaptation of a guided low-intensity behavioral activation intervention for people with dementia in Sweden : a qualitative study exploring the needs and preferences of key stakeholders 2024 In: BMC Geriatrics. - : Springer. - 1471-2318. ; 24:113 Journal article (peer-reviewed)abstract BackgroundDespite depression being prevalent in people with dementia, contributing to negative health outcomes and placing increased burden on individuals and family members, access to psychological interventions is limited. A potential solution is guided low-intensity behavioral activation, supported by informal caregivers and guided by healthcare professionals. However, it is necessary to adapt interventions to meet the needs and preferences of key stakeholders to enhance acceptability and relevance. Study objectives were to: (1) explore needs and preferences concerning the content and delivery model of the guided low-intensity behavioral activation intervention; and (2) adapt the intervention to ensure cultural appropriateness, relevancy, and acceptability to people with dementia and their caregivers in Sweden.MethodsSemi-structured interviews and focus group discussions were conducted with key stakeholders, including healthcare professionals (n = 18), community stakeholders (n = 7), people with dementia (n = 8), and informal caregivers (n = 19). A draft of the written low-intensity behavioral activation intervention and a description of the proposed intervention delivery model were provided to participants. Open-ended questions explored the perceived relevance of the intervention, alongside needs and preferences concerning content and delivery. A manifest content analysis approach was adopted.ResultsContent analysis resulted in three categories: Content, Delivery procedures, and Illness trajectory. Results highlighted a need to consider the intervention Content via increased cultural adaptation to the Swedish context, and increasing the inclusiveness of intervention content. Delivery procedures were identified as needing to be flexible given the unpredictable nature of caring for people with dementia, with the provision of additional guidance to informal caregivers supporting the intervention. Illness trajectory was viewed as essential to consider, with the intervention regarded as suitable for those early in the dementia trajectory, alongside a need to reduce workbook text to minimize burden given dementia symptomology.ConclusionsThe intervention and proposed delivery model were generally well received by all stakeholders. We were able to identify key adaptations to enhance cultural appropriateness, relevancy, and acceptability for a currently neglected population. Results will inform a feasibility study to explore the feasibility and acceptability of the intervention and study procedures to inform the design of a future superiority randomized controlled trial.
36.	Boiso, Samuel, et al. (author) ABCB1 gene polymorphisms are associated with suicide in forensic autopsies 2013 In: Pharmacogenetics & Genomics. - : Lippincott, Williams and Wilkins. - 1744-6872 .- 1744-6880. ; 23:9, s. 463-469 Journal article (peer-reviewed)abstract Background Polymorphisms in ABCB1 have the ability to affect both the function and the expression of the transporter protein P-glycoprotein and may lead to an altered response for many drugs including some antidepressants and antipsychotics.Objective The aim of this study was to examine the impact of the ABCB1 polymorphisms 1199Gandgt;A, 1236Candgt;T, 2677Gandgt;T/A, and 3435Candgt;T in deaths by suicide.Patients and methods A total of 998 consecutive Swedish forensic autopsies performed in 2008 in individuals 18 years of age or older, where femoral blood was available and a toxicological screening had been performed, were investigated. Genotypes were assessed with pyrosequencing and information on the cause and manner of each death was obtained from the forensic pathology and toxicology databases.Results There was a significantly higher frequency of the T allele at positions 1236, 2677, and 3435 among the suicide cases compared with the nonsuicide cases.Conclusion Our result from forensic cases suggests that ABCB1 polymorphisms are associated with an increased risk for completed suicides. The biological mechanisms involved and the clinical implications for these findings are largely unknown and need to be examined further.
37.	Bosaeus, Marja, et al. (author) A randomized longitudinal dietary intervention study during pregnancy: effects on fish intake, phospholipids, and body composition 2015 In: Nutrition Journal. - : Springer Science and Business Media LLC. - 1475-2891. ; 14:1 Journal article (peer-reviewed)abstract Background Fish and meat intake may affect gestational weight gain, body composition and serum fatty acids. We aimed to determine whether a longitudinal dietary intervention during pregnancy could increase fish intake, affect serum phospholipid fatty acids, gestational weight gain and body composition changes during pregnancy in women of normal weight participating in the Pregnancy Obesity Nutrition and Child Health study. A second aim was to study possible effects in early pregnancy of fish intake and meat intake, respectively, on serum phospholipid fatty acids, gestational weight gain, and body composition changes during pregnancy. Methods In this prospective, randomized controlled study, women were allocated to a control group or to a dietary counseling group that focused on increasing fish intake. Fat mass and fat-free mass were measured by air-displacement plethysmography. Reported intake of fish and meat was collected from a baseline population and from a subgroup of women who participated in each trimester of their pregnancies. Serum levels of phospholipid arachidonic acid (s-ARA), eicosapentaenoic acid (s-EPA), and docosahexaenoic acid (s-DHA) were measured during each trimester. Results Weekly fish intake increased only in the intervention group (n=18) from the first to the second trimester (median difference 113 g, p=0.03) and from the first to the third trimester (median difference 75 g, p=0.01). In the first trimester, fish intake correlated with s-EPA (r=0.36, p=0.002, n=69) and s-DHA (r=0.34, p=0.005, n=69), and meat intake correlated with s-ARA (r=0.28, p=0.02, n=69). Fat-free mass gain correlated with reported meat intake in the first trimester (r=0.39, p=0.01, n=45). Conclusions Dietary counseling throughout pregnancy could help women increase their fish intake. Intake of meat in early pregnancy may increase the gain in fat-free mass during pregnancy.
38.	Bosaeus, Marja, et al. (author) Body Composition During Pregnancy: Longitudinal Changes and Method Comparisons 2020 In: Reproductive Sciences. - : Springer Science and Business Media LLC. - 1933-7191 .- 1933-7205. ; :27, s. 1477-1489 Journal article (peer-reviewed)abstract The Pregnancy Obesity Nutrition and Child Health study is a longitudinal study of reproductive health. Here we analyzed body composition of normal-weight and obese Swedish women by three methods during each trimester of pregnancy. Cross-sectional and longitudinal fat mass estimates using quantitative magnetic resonance (QMR) and bioelectrical impedance analysis (BIA) (Tanita MC-180MA-III) were compared with fat mass determined by air displacement plethysmography (ADP) in pregnancy weeks 8-12, 24-26, and 35-37 in normal-weight women (n = 122, BMI = 22.1 +/- 1.6 kg/m(2)) and obese women (n = 29, BMI = 34.6 +/- 3.6 kg/m(2)). ADP results were calculated from pregnancy-adjusted fat-free mass densities. Mean fat mass by QMR and ADP were similar in obese women, although with wide limits of agreement. In normal-weight women, QMR overestimated mean fat mass in all trimesters, with systematic overestimation at low fat mass values in trimesters 1 and 3. In obese women, fat mass by BIA was grossly underestimated and imprecise in all trimesters, especially at higher values in trimester 2. In normal-weight women, fat mass by BIA was moderately lower than by ADP in trimester 1, similar in trimester 2, and moderately higher in trimester 3. QMR and ADP assessed fat mass changes similarly in obese women, whereas BIA overestimated fat mass changes in normal-weight women. Mean fat mass and fat mass changes by QMR and pregnancy-adjusted ADP were similar in pregnant obese women. Mean fat mass by QMR and fat mass changes by BIA were higher than corresponding values determined by pregnancy-adjusted ADP in normal-weight women.
39.	Börjesson, Angelica, et al. (author) The Swedish teacher certification reform: Solving one problem and triggering others 2015 In: NERA2015, the 43rd annual congress of the Nordic Educational Research Association. Conference paper (other academic/artistic)
40.	Christmas, Matthew, et al. (author) Evolutionary constraint and innovation across hundreds of placental mammals 2023 In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6643 Journal article (peer-reviewed)abstract Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases (similar to 10.7%) in the human genome are unusually conserved across species (evolutionarily constrained) relative to neutrally evolving repeats, and 4552 ultraconserved elements are nearly perfectly conserved. Of 101 million significantly constrained single bases, 80% are outside protein-coding exons and half have no functional annotations in the Encyclopedia of DNA Elements (ENCODE) resource. Changes in genes and regulatory elements are associated with exceptional mammalian traits, such as hibernation, that could inform therapeutic development. Earth's vast and imperiled biodiversity offers distinctive power for identifying genetic variants that affect genome function and organismal phenotypes.
41.	De Fine Licht, Jenny, 1982, et al. (author) Här, där eller överallt? Medborgares åsikter om lokalisering av offentlig service 2023 In: Kapitel i Ulrika Andersson, Patrik Öhberg, Anders Carlander, Johan Martinsson & Nora Theorin (red) Ovisshetens tid. Göteborg: SOM-institutet, Göteborgs universitet.. - Göteborg : SOM-institutet, Göteborgs universitet. - 9789189673540 ; , s. 329-342 Book chapter (other academic/artistic)abstract Det här kapitlet handlar om svenska folkets åsikter om lokalisering av offentlig service. Vi analyserar uppfattningar relaterade till bevarande av skolor och stöd till livsmedelsbutiker i glesbygd, samt centralisering av universitet och sjukvård, och undersöker i vilken grad ideologiska och avståndsbaserade faktorer bidrar till att förklara åsiktsvariationen. Dramatiken i lokaliseringspolitiken beskrivs ofta som en konflikt mellan stad och land, eller centrum och periferi, men resultaten visar att bostadsort och avstånd till service inte alls är så avgörande som man skulle kunna tro. Det är svårt att koppla människors åsikter om lokalisering till var de bor. Däremot har ideologiska faktorer en viss betydelse. Våra resultat väcker därmed nya spännande frågor om vad som egentligen förklarar den stora åsiktspridning och de starka känslor som kommer till uttryck när politiker och medborgare hanterar dessa frågor.
42.	De Fine Licht, Jenny, 1982, et al. (author) Här, där eller överallt? – Tabellbilaga 2023 In: Bilaga till kapitlet de Fine Licht, Karlsson & Skoog (2023): "Här, där eller överallt? Medborgares åsikter om lokalisering av offentlig service". I Ulrika Andersson, Patrik Öhberg, Anders Carlander, Johan Martinsson & Nora Theorin (red) "Ovisshetens tid". Göteborg: SOM-institutet, Göteborgs universitet.. - Göteborg och Umeå : Göteborgs universitet och Umeå universitet. Other publication (other academic/artistic)abstract Denna PM är en bilaga till kapitlet de Fine Licht, Karlsson & Skoog (2023): Här, där eller överallt? Medborgares åsikter om lokalisering av offentlig service, publicerad i Ulrika Andersson, Patrik Öhberg, Anders Carlander, Johan Martinsson & Nora Theorin (red) Ovisshetens tid. Göteborg: SOM-institutet, Göteborgs universitet. I denna bilaga redovisas resultat på de frågor projektet Lokaliseringsutmaningen ställt i den nationella SOM-undersökningen 2022 och som ligger till grund för analyserna i ovan nämnda kapitel.
43.	De Fine Licht, Jenny, 1982, et al. (author) Location of public services : legitimacy, challenges, and solutions in Sweden 2024 Book (peer-reviewed)abstract This book assesses the challenges faced by local governments when deciding on the location of public services. Some physical signs of government presence are vital and generally welcomed within local communities. Schools, bus stops, care facilities, and public libraries are both crucial for the functioning and sustainability of communities, and symbolize governmental engagement. Conversely, other types of facilities are typically unwelcome. Waste and recycling stations, wind farms, and prisons often provoke protests from local residents. Drawing on evidence from Sweden, this book argues that decisions on how to locate services are inherently political, and that in order to succeed, authorities need to ensure that their policies are perceived as legitimate. It also demonstrates how the problem of locating public services is a universal issue, relevant to governments at all levels and in all countries. As urbanization and pressure on welfare systems grow, the problem of locating public services looks set to become more pressing, and the themes raised in the book are likely to remain relevant for years to come. It will appeal to researchers and practitioners in the fields of public administration and local government studies, as well as policymakers and public officials.
44.	De Fine Licht, Jenny, 1982, et al. (author) Närhet eller effektivitet – en kommunal utmaning 2023 In: Kommunal Ekonomi. - : Föreningen Sveriges kommunalekonomer. - 0282-0099 .- 2002-3995. ; 2023:2, s. 39-40 Journal article (other academic/artistic)
45.	Difs, Kristina (author) District Heating and CHP : Local Possibilities for Global Climate Change Mitigation 2010 Doctoral thesis (other academic/artistic)abstract Global warming, in combination with increasing energy demand and higher energy prices, makes it necessary to change the energy use. To secure the energy supply and to develop sustainable societies, construction of energy-efficient systems is at the same time most vital. The aim of this thesis is therefore to identify how a local energy company, producing district heating (DH), district cooling (DC) and electricity in combined heat and power (CHP) plants, can contribute to resource-efficient energy systems and cost-effective reductions of global carbon dioxide (CO2) emissions, along with its customers. Analyses have been performed on how a local energy company can optimise their DH and DC production and what supply-side and demand-side measures can lead to energy-efficient systems in combination with economic and climate change benefits. The energy company in focus is located in Linköping, Sweden. Optimisation models, such as MODEST and reMIND, have been used for analysing the energy systems. Scenario and sensitivity analyses have also been performed for evaluation of the robustness of the energy systems studied. For all analyses a European energy system perspective was applied, where a fully deregulated European electricity market with no bottlenecks or other system failures was assumed.In this thesis it is concluded that of the DH-supply technologies studied, the biomass gasification applications and the natural gas combined cycle (NGCC) CHP are the technologies with the largest global CO2 reduction potential, while the biomass-fuelled plant that only produces heat is the investment with the smallest global CO2 reduction and savings potential. However, the global CO2 reduction potential for the biomass integrated gasification combined cycle (BIGCC) CHP and NGCC CHP, the two technologies with highest electricity efficiencies, is highly dependent on the assumptions made about marginal European electricity production. Regarding the effect on the DH system cost the gasification application integrated with production of renewable biofuels (SNG) for the transport sector is the investment option with the largest savings potential for lower electricity prices, while with increasing electricity prices the BIGCC and NGCC CHP plants are the most cost-effective investment options. The economic outcome for biomass gasification applications is, however, dependent on the level of policy instruments for biofuels and renewable electricity. Moreover, it was shown that the tradable green certificates for renewable electricity can, when applied to DH systems, contribute to investments that will not fully utilise the DH systems’ potential for global CO2 emissions reductions.Also illustrated is that conversion of industrial processes, utilising electricity and fossil fuels, to DH and DC can contribute to energy savings. Since DH is mainly used for space heating, the heat demand for DH systems is strongly outdoor temperature-dependent. By converting industrial processes, where the heat demand is often dependent on process hours instead of outdoor temperature, the heat loads in DH systems can become more evenly distributed over the year, with increased base-load heat demand and increased electricity generation in CHP plants as an outcome. This extra electricity production, in combination with the freed electricity when converting electricity-using processes to DH, can replace marginal electricity production in the European electricity market, resulting in reduced global CO2 emissions.Demonstrated in this thesis is that the local energy company, along with its customers, can contribute to reaching the European Union’s targets of reducing energy use and decreasing CO2 emissions. This can be achieved in a manner that is cost-effective to both the local energy company and the customers.
46.	Djuric Ilic, Danica (author) With district heating toward a sustainable future : System studies of district heating and cooling that interact with power, transport and industrial sectors 2014 Doctoral thesis (other academic/artistic)abstract The aim of this thesis is to identify measures which should be taken in DH systems (DHSs) in order to contribute to the development of the DHSs and other energy systems (especially transport, industrial and power sectors) toward sustainability.Four business strategies were analysed: delivering excess heat from biofuel production industry to DHSs, conversion of industrial processes to DH, integration of biofuel production in DHSs and integration of DHdriven absorption cooling technology in DHSs. Delivering excess heat from biofuel production industry to DHSs was analysed with a focus on the biofuel production costs for four biofuel production technologies. Integration of biofuel production and integration of DH-driven absorption cooling technology in DHSs were analysed with a focus on Stockholm’s DHS, using an optimisation model framework called MODEST. When the conversion of industrial processes to DH was analysed, DHSs and industrial companies in Västra Götaland, Östergötland and Jönköping counties were used as case studies; a method for heat load analysis called MeHLA was used to analyse the effects on the local DHSs.The results showed that when considering biomass an unlimited resource, by applying the abovementioned business strategies DH has a potential to reduce global fossil fuel consumption and global GHG emissions associated with power, industrial and transport sectors.DH producers may contribute to the sustainable development of the transport sector by buying excess heat from the biofuel production industry. This business strategy results in lower biofuel production costs, which promotes development of biofuel production technologies that are not yet commercial. Moreover, introduction of large-scale biofuel production into local DHSs enables development of local biofuel supply chains; this may facilitate the introduction of biofuel in the local transport sectors and subsequently decrease gasoline and fossil diesel use. Conversion of industrial processes from fossil fuels and electricity to DH is a business strategy which would make the industry less dependent on fossil fuels and fossil fuelbased electricity. DH may also contribute to the sustainable development of the industry by buying waste heat from industrial processes, since this strategy increases the total energy efficiency of the industrial processes and reduces production costs. Furthermore, DH has a possibility to reduce fossil fuel consumption and subsequently GHG emissions in the power sector by producing electricity in biomass- or waste-fuelled CHP plants.When the marginal electricity is associated with high GHG emissions (e.g. when it is produced in coal-fired condensing power (CCP)) plants, the reduction of the marginal electricity production (due to the conversion of industrial processes from electricity to DH and due to the conversion of compression cooling to DHdriven absorption cooling) results in higher environmental benefits. On the other hand, the introduction of biofuel production into DHSs becomes less attractive from an environmental viewpoint, because the investments in biofuel production instead of in CHP production lead to lower electricity production in the DHSs. The increased DH use in industry and introduction of the biofuel production and DH-driven absorption cooling production into the DHSs lead to increased biomass use in the DHSs. Because of this, if biomass is considered a limited resource, the environmental benefits of applying these business strategies are lower or non-existent.
47.	Einarsdottir, Berglind Osk, 1979, et al. (author) A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma 2018 In: Cell Death & Disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 9:8 Journal article (peer-reviewed)abstract Karonudib (TH1579) is a novel compound that exerts anti-tumor activities and has recently entered phase I clinical testing. The aim of this study was to conduct a pre-clinical trial in patient-derived xenografts to identify the possible biomarkers of response or resistance that could guide inclusion of patients suffering from metastatic melanoma in phase II clinical trials. Patient-derived xenografts from 31 melanoma patients with metastatic disease were treated with karonudib or a vehicle for 18 days. Treatment responses were followed by measuring tumor sizes, and the models were categorized in the response groups. Tumors were harvested and processed for RNA sequencing and protein analysis. To investigate the effect of karonudib on T-cell-mediated anti-tumor activities, tumor-infiltrating T cells were injected in mice carrying autologous tumors and the mice treated with karonudib. We show that karonudib has heterogeneous anti-tumor effect on metastatic melanoma. Thus, based on the treatment responses, we could divide the 31 patient-derived xenografts in three treatment groups: progression group (32%), suppression group (42%), and regression group (26%). Furthermore, we show that karonudib has anti-tumor effect, irrespective of major melanoma driver mutations. Also, we identify high expression of ABCB1, which codes for p-gp pumps as a resistance biomarker. Finally, we show that karonudib treatment does not hamper T-cell-mediated anti-tumor responses. These findings can be used to guide future use of karonudib in clinical use with a potential approach as precision medicine.
48.	Ejlertsson, Jörgen, et al. (author) Anaerobic Degradation of Nonylphenol Mono- and Diethoxylates in Digestor Sludge, Landfilled Municipal Solid Waste, and Landfilled Sludge 1999 In: Environmental Science and Technology. - : American Chemical Society (ACS). - 1086-931X .- 1520-6912 .- 0013-936X .- 1520-5851. ; 33:2, s. 301-306 Journal article (peer-reviewed)abstract The aim of this study was to investigate the extent to which anaerobic digestor sludge, landfilled sludge, and landfilled municipal solid waste (MSW) degrade NPEOs under methanogenic conditions. NPEO1 and NPEO2 (NPEO1-2), used in a mixture, were chosen as model compounds. Anaerobic experimental bottles were amended with 100% digestor sludge at three different concentrations of NPEO1-2: 2, 60, and 308 mg L-1. [U-14C]-NPEO1-2 was used to detect any possible decomposition of the aromatic moiety of the NPEO1-2. All inoculates used degraded NPEO1-2 at 2 mg L-1, with nonylphenol (NP) forming the ultimate degradation product. The NP formed was not further degraded, and the incubations with labeled NPEO showed that the aromatic structure remained intact. Both landfill inoculates also transformed NPEO1-2 at 60 mg L-1. CH4 production was temporarily hampered in bottles with MSW landfill inoculum at 60 and 308 mg L-1. With 2 mg L-1 of NPEO, CH4 production closely followed that in the controls. Both NP and NPEO1-2 interacted with the organic matter which resulted in sorption to the solid phase.
49.	Elam, Katarina, et al. (author) Educating Responsible Citizens; Intercultural Competence and Aesthetic Education 2017 In: Learning Scenarios for Social and Cultural Change: Bildung Through Academic Teaching.. - : Peter Lang. - 9783631729304 Book chapter (peer-reviewed)abstract The article is a joint product of researchers working within different disciplines and with different kinds of knowledge interests, but united by a common interest in the question of how aesthetic education can lead to intercultural competence and education of responsible citizens. What characterizes aesthetic education and how can a clarification of pedagogical tools of such education help us clarify intercultural competence as a learning goal? What are the connections between intercultural education and aesthetic education and how can the latter contribute to the former? Our approach to these issues is a practical one. This means that our efforts are focused on a critical investigation of the conditions of the possibility of intercultural education. Our main argument in the article is that the core of intercultural competence is of a particular type, is active rather than passive and open to radically different experiences than our own. Having this starting point, we in the first step identify some tools through which intercultural competence and education can be made possible. The notions of aesthetic education and empathy are among these tools. Identifying these tools, we in the next step connect the identified tools to basic impediments in the way of intercultural education like that of obstacles for intercultural competence to take form like hidden prejudices of educators in order to remove them and clear the way for intercultural education. As a result of these two steps, educators engaged in, and pupils educated by intercultural education, become empowered. They are then enabled to clarify their hidden prejudices and counteract them instead of being steered by them. They also become empathetic and “responsible citizens”.
50.	Eloff, Emma, et al. (author) Autoantibodies are major predictors of arthritis development in patients with anti-citrullinated protein antibodies and musculoskeletal pain 2021 In: Scandinavian Journal of Rheumatology. - : Taylor & Francis Group. - 0300-9742 .- 1502-7732. ; 50:3, s. 189-197 Journal article (peer-reviewed)abstract Objectives: Predictors of arthritis development are highly warranted among patients with anti-citrullinated protein antibodies (ACPAs) and musculoskeletal symptoms to optimize clinical management. We aimed to identify clinical and laboratory predictors of arthritis development, including biochemically assessed alcohol consumption, among ACPA-positive patients with musculoskeletal pain.Method: 82 ACPA-positive individuals with musculoskeletal pain but no clinical arthritis were followed for a median of 72 months (interquartile range 57–81 months). We evaluated the prognostic value of baseline clinical and laboratory factors including smoking, symptom duration, age, gender, shared epitope, rheumatoid factor (RF), anti-carbamylated protein antibodies, ACPA levels, erythrocyte sedimentation rate, C-reactive protein levels, tender joint count, patient-reported general well-being, 28-joint Disease Activity Score, and alcohol consumption as measured by phosphatidyl ethanol (PEth) levels in whole blood.Results: During follow-up, 48% developed at least one arthritis. Multivariable analysis revealed an increased risk of arthritis development with RF positivity [hazard ratio (HR) = 2.3, 95% confidence interval (CI) 1.1–4.8, p = 0.028] and higher ACPA levels (HR = 1.0, 95% CI 1.000–1.001, p = 0.002). High levels of RF (HR = 4.4, 95% CI 1.7–11) entailed the highest HR in this ACPA-positive population. Neither clinical characteristics nor alcohol consumption measured by PEth conferred significant prognostic value.Conclusions: ACPA levels and concurrent presence of RF are independent predictors of arthritis development among ACPA-positive patients with musculoskeletal pain. The results are compatible with a dose–response relationship between RA-related autoantibodies and risk of arthritis development.

Skapa referenser, mejla, bekava och länka

Permalink

Träfflista för sökning "WFRF:(Karlsson Louise) "

Refine your search

Year