| 1. |
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| 2. |
- Agrenius, Stefan, 1948, et al.
(author)
-
Marine Invertebrates
- 2005
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In: The 2005 Red List of Swedish Species. - Uppsala : Artdatabanken, SLU. - 9188506304 ; , s. 409-447
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Book chapter (other academic/artistic)
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| 3. |
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| 4. |
- Bjelke, Ulf, et al.
(author)
-
Crustacea : Kräftdjur - crustaceans
- 2010
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In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 487-493
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Book chapter (other academic/artistic)
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| 5. |
- Bjelke, Ulf, et al.
(author)
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Mollusca : Blötdjur - Molluscs
- 2010
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In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 495-505
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Book chapter (other academic/artistic)
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| 6. |
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| 7. |
- Karlsson, Anna, et al.
(author)
-
Anthozoa : Koralldjur - Anthozoans
- 2010
-
In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 515-518
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Book chapter (other academic/artistic)
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| 8. |
- Karlsson, Anna, et al.
(author)
-
Brachiopoda : Armfotingar - Brachiopods
- 2010
-
In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 507-509
-
Book chapter (other academic/artistic)
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| 9. |
- Karlsson, Anna, et al.
(author)
-
Echinodermata : Tagghudingar - Echinoderms
- 2010
-
In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken,SLU. - 9789188506351 ; , s. 339-344
-
Book chapter (other academic/artistic)
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| 10. |
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| 11. |
- Karlsson, Anna, et al.
(author)
-
Tunicata : Manteldjur - Tunicates
- 2010
-
In: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 333-338
-
Book chapter (other academic/artistic)
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| 12. |
- Wallin, Gunnar B, 1936, et al.
(author)
-
Sympathetic single axonal discharge after spinal cord injury in humans: activity at rest and after bladder stimulation
- 2014
-
In: Spinal Cord. - : Springer Science and Business Media LLC. - 1362-4393 .- 1476-5624. ; 52:6, s. 434-438
-
Journal article (peer-reviewed)abstract
- Study design: Clinical experimental mechanistic study. Objectives: (1) To determine in three spinal cord-injured patients whether individual muscle sympathetic nerve fibres below the level of the spinal lesion display spontaneous activity. (2) To determine in these patients if individual sympathetic vasoconstrictor fibres show a prolonged discharge following a bladder stimulus. Methods: Microneurographic recordings of action potentials from individual muscle nerve sympathetic fibres in a peroneal nerve. Recordings of skin blood flow and electrodermal responses in a foot. Results: In all patients, there was sparse ongoing spontaneous impulse traffic in individual sympathetic fibres. Brisk mechanical pressure over the urinary bladder evoked a varying number of action potentials in individual fibres, but the activity was brief and did not continue after the end of the evoked multiunit burst. Conclusion: Prolonged discharges in individual sympathetic fibres are unlikely to contribute to a long duration of blood pressure increases induced by brief bladder stimuli.
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| 13. |
- Ahlberg, Erik, et al.
(author)
-
No particle mass enhancement from induced atmospheric ageing at a rural site in northern Europe
- 2019
-
In: Atmosphere. - : MDPI AG. - 2073-4433. ; 10:7
-
Journal article (peer-reviewed)abstract
- A large portion of atmospheric aerosol particles consists of secondary material produced by oxidation reactions. The relative importance of secondary organic aerosol (SOA) can increase with improved emission regulations. A relatively simple way to study potential particle formation in the atmosphere is by using oxidation flow reactors (OFRs) which simulate atmospheric ageing. Here we report on the first ambient OFR ageing experiment in Europe, coupled with scanning mobility particle sizer (SMPS), aerosol mass spectrometer (AMS) and proton transfer reaction (PTR)-MS measurements. We found that the simulated ageing did not produce any measurable increases in particle mass or number concentrations during the two months of the campaign due to low concentrations of precursors. Losses in the reactor increased with hydroxyl radical (OH) exposure and with increasing difference between ambient and reactor temperatures, indicating fragmentation and evaporation of semivolatile material.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Ahlgren, Serina, et al.
(author)
-
Review of methodological choices in LCA of biorefinery systems - key issues and recommendations
- 2015
-
In: Biofuels, Bioproducts and Biorefining. - : Wiley. - 1932-1031 .- 1932-104X. ; 9:5, s. 606-619
-
Research review (peer-reviewed)abstract
- The current trend in biomass conversion technologies is toward more efficient utilization of biomass feedstock in multiproduct biorefineries. Many life-cycle assessment (LCA) studies of biorefinery systems have been performed but differ in how they use the LCA methodology. Based on a review of existing LCA standards and guidelines, this paper provides recommendations on how to handle key methodological issues when performing LCA studies of biorefinery systems. Six key issues were identified: (i) goal definition, (ii) functional unit, (iii) allocation of biorefinery outputs, (iv) allocation of biomass feedstock, (v) land use, and (vi) biogenic carbon and timing of emissions. Many of the standards and guidelines reviewed here provide only general methodological recommendations. Some make more specific methodological recommendations, but these often differ between standards. In this paper we present some clarifications (e.g. examples of research questions and suitable functional units) and methodological recommendations (e.g. on allocation).
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| 18. |
- Alfredsson, Magnus, et al.
(author)
-
Funktionskriterier för vägkonstruktioner : Förstudie
- 2010
-
Reports (other academic/artistic)abstract
- Det projekt som här rapporteras har som syfte att identifiera och beskriva de svårigheter och möjligheter som totalentreprenader medför, respektive erbjuder, för alla parter. Målet är att utveckla totalentreprenader på ett sådant sätt att branschens effektivitet ökas. Denna rapport är en förstudie där det studerats vilka krav som byggherren ska ställa på utföraren av en vägkonstruktion i en totalentreprenad med funktionsansvar och hur utföraren ska verifiera kraven. Arbetet har genomförts med medlemmar från olika aktörer i branschen och omfattat främst litteraturstudier och intervjuer. Kunskaper och erfarenheter har sammanställts och analyserats för att slutligen kondenseras ned till ett antal förslag till fortsatt arbete.Förstudien har pekat ut ett antal områden som viktiga för att påskynda framtida utveckling av totalentreprenader:Terminologi – idag råder viss begreppsförvirringAnalys av funktionella krav i tidigare projektTrafikantkravMiljökravUtveckling av funktionella krav i samverkanVäghållarekonomiRegelbetingade begränsningar av funktionella kravUppföljning och underlättande av erfarenhetsackumuleringImplementering av nya mått och mätmetoder
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| 19. |
- Alm, Love
(author)
-
Cluster investigations of the extent and altitude distribution of the auroral density cavity
- 2015
-
Doctoral thesis (other academic/artistic)abstract
- The auroral density cavity constitutes the boundary between the cold, dense ionospheric plasma and the hot, tenuous plasma sheet plasma. The auroral density cavity is characterized by low electron density and particle populations modified by parallel electric fields. Inside the cavity the electron densities can be as much as a factor 100-1000 lower than same altitude outside the cavity.The Cluster mission's wide range of instruments, long lifetime and ability to make multi-spacecraft observations has been very successful. Over its 15 year lifespan, the Cluster satellites have gathered data on auroral density cavities over a large altitude range and throughout an entire solar cycle, providing a vast data material.The extent of the density cavity and acceleration region is large compared to the typical altitude coverage of a satellite crossing the cavity. This makes it difficult to produce a comprehensive altitude/density profile from a single crossing. In order to facilitate comparisons between data from different events, we introduce a new reference frame, pseudo altitude. Pseudo altitude describes the satellites' position relative to the acceleration region, as opposed to relative to the Earth. This pseudo altitude is constructed by dividing the parallel potential drop below the satellite with the total parallel potential drop. A pseudo altitude of 0 corresponds to the bottom of the acceleration region and a pseudo altitude of 1 to the top of the acceleration region. As expected, the pseudo altitude increases with altitude. The electron density exhibits an anti-correlation with the pseudo altitude, the density becomes lower close to the upper edge of the acceleration region. The upper edge of the acceleration region is located between a geocentric altitude of 4.375 and 5.625 RE. Above the upper edge of the acceleration region, the electron density continues to decrease for the entire range of the study, 3.0-6.5 RE. This is much further than the geocentric altitude range of 2-3 RE which is suggested by previous models. We can conclude that the auroral density cavity is not confined by the auroral acceleration region, as suggested by previous models, and may extend all the way to the plasma sheet.
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| 20. |
- Alm, Love, et al.
(author)
-
Electron density and parallel electric field distribution of the auroral density cavity
- 2015
-
In: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 120:11, s. 9428-9441
-
Journal article (peer-reviewed)abstract
- We present an event study in which Cluster satellites C1 and C3 encounters the flux tube of a stable auroral arc in the pre-midnight sector. C1 observes the mid cavity, while C3 enters the flux tube of the auroral arc at an altitude which is below the acceleration region, before crossing into the top half of the acceleration region. This allows us to study the boundary between the ionosphere and the density cavity, as well as large portion of the upper density cavity. The position of the two satellites, in relation to the acceleration region, is described using a pseudo altitude derived from the distribution of the parallel potential drop above and below the satellites.The electron density exhibits an anti-correlation with the pseudo altitude, indicating that the lowest electron densities are found near the top of the density cavity. Over the entire pseudo altitude range, the electron density distribution is similar to a planar sheath, formed out of a plasma sheet dominated electron distribution, in response to the parallel electric field of the acceleration region. This indicates that the parallel electric fields on the ionosphere-cavity boundary, as well as the mid cavity parallel electric fields, are part of one unified structure rather than two discrete entities.The results highlight the strong connection between the auroral density cavity and auroral acceleration as well as the necessity of studying them in a unified fashion.
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| 21. |
- Alm, Love, et al.
(author)
-
In situ observations of density cavities extending above the auroral acceleration region
- 2014
-
In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 119:7, s. 5286-5294
-
Journal article (peer-reviewed)abstract
- The uppermost part of a stable potential structure in the auroral acceleration region was studied using simultaneous observations of Cluster satellites C1 and C3. Both satellites observe a monotonically decreasing electron density as they ascend through the auroral acceleration region. As C1 exits the top of the auroral acceleration region, the electron densities continue to decrease, and the minimum electron density is reached 14 km above the upper edge of the auroral acceleration region. The electron density does not return to noncavity values until the spacecraft exits the potential structure's flux tube. The data indicate that the auroral density cavity is not confined by the potential structure and may extend above the auroral acceleration region.
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| 22. |
- Alm, Love, et al.
(author)
-
Pseudo altitude : A new perspective on the auroral density cavity
- 2013
-
In: Journal of Geophysical Research A: Space Physics. - : American Geophysical Union (AGU). - 2169-9380. ; 118:7, s. 4341-4351
-
Journal article (peer-reviewed)abstract
- Studying the density distribution inside the auroral density cavity is complicated by the difficulties in achieving simultaneous measurements within the same flux tube at different altitudes. Comparisons between different events are complicated by variations in both the location of the density cavity and the location of the related potential structure. Describing the spacecraft's location inside the density cavity relative to the potential structure instead of the Earth offers a more practical and consistent frame of reference, a pseudo altitude. The pseudo altitude is determined by comparing the potential drop above the spacecraft, as determined from the characteristic energy of the downward electrons, with the parallel potential drop below the spacecraft, determined from the characteristic energy of the upward ions. A pseudo altitude of 0 corresponds to the bottom of the potential structure and a pseudo altitude of 1 to the top of the structure. Seven events from 2008 were selected, each of which corresponds to a Cluster crossing of a mainly quasi-static potential structure. All of the events exhibit a consistent anticorrelation between the pseudo altitude and the electron density. No upper limit of the density cavity can be observed, while all cavities have a lower limit above a pseudo altitude of 0.33. These observations show that the auroral density cavity is predominately concentrated to the upper parts of the quasi-static potential structure.
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| 23. |
- Alm, Love, et al.
(author)
-
Statistical altitude distribution of the auroral density cavity
- 2015
-
In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:2, s. 996-1006
-
Journal article (peer-reviewed)abstract
- The statistical altitude distribution of auroral density cavities located between 3.0 and 6.5 R-E is investigated using in situ observations from flux tubes exhibiting auroral acceleration. The locations of the observations are described using a pseudo altitude derived from the distribution of the parallel potential drop above and below the satellite. The upper edge of the auroral acceleration region is observed between 4.375 and 5.625 R-E. Above 6.125 R-E, none of the events exhibit precipitating inverted V electrons, though the upward ion beam can be observed. This indicates that the satellites are located inside the same flux tube as, but above, the auroral acceleration region. The electron density decreases as we move higher into the acceleration region. The spacecraft potential continues to decrease once above the acceleration region, indicating that the density cavity extends above the acceleration region. From 3.0 to 4.375 R-E the pseudo altitude increases by 0.20 per R-E, consistent with a distributed parallel electric field. Between 4.375 and 5.625 R-E the pseudo altitude increases weakly, by 0.01 per R-E, due to an increasing number of events per altitude bin, which are occurring above the acceleration region. Above 5.625 R-E the pseudo altitude increases by 0.28 per R-E, due to a rapid increase in the number of events per altitude bin occurring above the acceleration region, indicating that the remaining parallel potential drop is concentrated in a narrow region at the upper edge of the acceleration region, rather than in a distributed parallel electric field.
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| 24. |
|
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| 25. |
- Alvez, Maria Bueno, et al.
(author)
-
Next generation pan-cancer blood proteome profiling using proximity extension assay
- 2023
-
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
-
Journal article (peer-reviewed)abstract
- A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
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| 26. |
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| 27. |
|
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| 28. |
- Andersson, Fredrik, et al.
(author)
-
Organisatoriska vägval -- En studie av Försäkringskassans förändringsarbete
- 2011
-
In: Nordiske Organisasjonsstudier. - 1501-8237. ; 13:4, s. 53-76
-
Journal article (peer-reviewed)abstract
- The Swedish Social Insurance Agency is an important part of the Swedish welfare state. The Agency has recently made a number of major changes, such as establishing a new internal organization and reforming processes for decision making. Many of these changes have been controversial. Critics have complained that the Agency shows a lack of efficiency, has failed to make payments on time, and has been too harsh in its application of eligibility rules. The changes have put the agency at a number of crossroads, many of them recurring from earlier reforms, in dealing with problems such as regional differences in the application of rules. In this article, some of these choices are discussed. The discussion departs from four dichotomies: uniformity-local adaptation; centralization-decentralization; specialization-generalist approaches; and closeness-distance. These dichotomies are illustrated with examples from the agency. The general conclusion is that although the change process has taken a rocky road, there has been a great deal of internal consistency in the combination of measures taken.
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| 29. |
- Andersson, Fredrik, et al.
(author)
-
Speglingar av en förvaltning i förändring: Reformeringen av Försäkringskassan
- 2012
-
Book (other academic/artistic)abstract
- Svensk statsförvaltning genomgår, precis som privat sektor, ständigt förändringar och omstruktureringar, drivna av olika samhällstrender, ledarskapsidéer och politiska styrfilosofier. Vid dessa förändringar ställs verksamheten inför vägval som på olika sätt kan påverka dess förmåga att leva upp till omgivningens krav och förväntningar. Samtidigt finns inte utrymme för risktagande, eftersom förvaltningens agerande och beslut kan vara avgörande för individers försörjning och framtid. Det ställer stora krav på dessa myndigheter, som balanserar ekonomimål, demokratimål och rättssäkerhetsmål. Denna bok avser att spegla olika organisatoriska dilemman och utmaningar som myndigheter i svensk och internationell statsförvaltning kan möta. Detta sker med utgångspunkt i en studie av Försäkringskassans enmyndighetsreform år 2005 och dess förändringsarbete under åren därefter. Bokens författare kommer från tre olika ämnesområden: företagsekonomi, nationalekonomi och statsvetenskap. Samtliga är knutna till Lunds universitet och till forskningsprogrammet ”Från många till en?” (2008-2012). Programmet finansierades av Försäkringskassan, men genomfördes självständigt. Med boken hoppas författarna kunna öka förståelsen – och intresset - för frågor om organisation, styrning och ledning i en statsförvaltning i förändring.
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| 30. |
- Andersson, Maria, 1965-
(author)
-
Cooperation in local electricity markets : modelling of technical measures
- 1997
-
Doctoral thesis (other academic/artistic)abstract
- This thesis presents a system analysis for co-operation in local electricity markets including distributors and customers. The purpose of co-operation is to minimise the system cost of local markets by introducing system measures, such as end-use measures and municipal co-generation plants. Co-operation will strengthen the position of local markets in the national as well as future international electricity markets. With end-use measures local markets will achieve flexibility, additional reserve capacity and ability to avoid sudden large costs for peak loads. Biomass-fired cogeneration plants can become of great importance in an international market. In Sweden there is a simultaneous demand for electricity and district heating, many local markets already include district heating systems and there are major forest areas which can contribute with renewable fuel. The system analysis is partly based on the simulation model (INDSIM) and the linear programming model (MODEST). The simulation model has been further developed (STRATO) to include calculation of system costs. Shadow price analysis has been developed in order to study incentives for system measures. Calculation procedures have been developed that describe cooperation between distributor and customer. Six case studies of a selection of real, existing local markets in Sweden are presented. The studies show the potential economical effects of co-operation measured by system costs and shadow prices. Co-operation has been considered between demand- and supply-side, electricity- and district heating systems and also between different time periods. In a typical local market with 90 000 inhabitants, if end use measures are introduced without cooperation the system cost of the distributor will increase by 14 million SEK for a time period of 25 years. If instead end-use measures are introduced in co-operation, together with a biomass-fired cogeneration plant, the system cost of the local market will be reduced by 444 million SEK. Furthermore, the use of biomass in the local market is increased from 36 to 72 % while the use of oil is decreased from 34 to 1%. Another case study of another local market (50 000 inhabitants) shows that end-use measures will reduce the system cost (excluding investment costs) of an industry by 50 % corresponding to 1.3 million SEK for one year. The end-use measures imply reduced power demand during peak load periods in the local market and increased power demand during non- peak load periods.
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| 31. |
- Andersson, Maria, 1965-
(author)
-
Cost-effective incentives for local electric utilities and industries in co-operation : modelling of technical measures
- 1993
-
Licentiate thesis (other academic/artistic)abstract
- In the Swedish electricity system there is a great potential for increasing the cost efficiency of the electricity use. However, today the economic incentives, offered for instance by existing electricity rates, are too weak to improve the use of the system. On the Swedish electricity market there are, at least, three different actors, the power producer, the distributor and the customer. Today these actors act separately due to low awareness of the costs for electricity generation, over the year and the day. If the actors are aware of the real electricity costs, cost-effective incentives will arise to introduce energy system measures that will reduce the energy system cost considerably. The thesis presents two energy system analyses of an existing Swedish municipality. The first analysis deals with the introduction of industrial end-use measures, with the local utility’s existing electricity rates as boundary conditions. The analysis is carried out with a simulation model for electricity use in industries. The second analysis deals with the introduction of energy system measures, on the municipal supply-side and demand-side, when the local electric utility and the customers are regarded as one system. The analysis is carried out with an optimization model, that is based on linear programming. The results show that if 17 industries introduce end-use measures, with the existing electricity rates as boundary conditions, their energy system costs will be reduced by 12 MSEK for a time period of 10 years, whereas the local utility will increase its energy system cost by 6 MSEK. However, if there is a co-operation between the local electric utility and the customers, their joint energy system cost will be reduced by 330 MSEK for a time period of 10 years.
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| 32. |
- André, Mats, et al.
(author)
-
Lower hybrid waves at comet 67P/Churyumov-Gerasimenko
- 2017
-
In: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S29-S38
-
Journal article (peer-reviewed)abstract
- We investigate the generation of waves in the lower hybrid frequency range by density gradients in the near plasma environment of comet 67P/Churyumov-Gerasimenko. When the plasma is dominated by water ions from the comet, a situation with magnetized electrons and unmagnetized ions is favourable for the generation of lower hybrid waves. These waves can transfer energy between ions and electrons and reshape the plasma environment of the comet. We consider cometocentric distances out to a few hundred km. We find that when the electron motion is not significantly interrupted by collisions with neutrals, large average gradients within tens of km of the comet, as well as often observed local large density gradients at larger distances, are often likely to be favourable for the generation of lower hybrid waves. Overall, we find that waves in the lower hybrid frequency range are likely to be common in the near plasma environment.
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| 33. |
- Arendt, Maja Louise, et al.
(author)
-
The ABCC4 gene is associated with pyometra in golden retriever dogs
- 2021
-
In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11
-
Journal article (peer-reviewed)abstract
- Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between breeds (3-66%). The clear breed predisposition suggests that genetic risk factors are involved in disease development. To identify genetic risk factors associated with the disease, we performed a genome-wide association study (GWAS) in golden retrievers, a breed with increased risk of developing pyometra (risk ratio: 3.3). We applied a mixed model approach comparing 98 cases, and 96 healthy controls and identified an associated locus on chromosome 22 (p = 1.2 x 10(-6), passing Bonferroni corrected significance). This locus contained five significantly associated SNPs positioned within introns of the ATP-binding cassette transporter 4 (ABCC4) gene. This gene encodes a transmembrane transporter that is important for prostaglandin transport. Next generation sequencing and genotyping of cases and controls subsequently identified four missense SNPs within the ABCC4 gene. One missense SNP at chr22:45,893,198 (p.Met787Val) showed complete linkage disequilibrium with the associated GWAS SNPs suggesting a potential role in disease development. Another locus on chromosome 18 overlapping the TESMIN gene, is also potentially implicated in the development of the disease.
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| 34. |
- Arro, Giuseppe, et al.
(author)
-
Large-scale Linear Magnetic Holes with Magnetic Mirror Properties in Hybrid Simulations of Solar Wind Turbulence
- 2024
-
In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 970:1
-
Journal article (peer-reviewed)abstract
- Magnetic holes (MHs) are coherent magnetic field dips whose size ranges from fluid to kinetic scale, ubiquitously observed in the heliosphere and in planetary environments. Despite the long-standing effort in interpreting the abundance of observations, the origin and properties of MHs are still debated. In this Letter, we investigate the interplay between plasma turbulence and MHs, using a 2D hybrid simulation initialized with solar wind parameters. We show that fully developed turbulence exhibits localized elongated magnetic depressions, whose properties are consistent with linear MHs frequently encountered in space. The observed MHs develop self-consistently from the initial magnetic field perturbations by trapping hot ions with large pitch angles. Ion trapping produces an enhanced perpendicular temperature anisotropy that makes MHs stable for hundreds of ion gyroperiods, despite the surrounding turbulence. We introduce a new quantity, based on local magnetic field and ion temperature values, to measure the efficiency of ion trapping, with potential applications to the detection of MHs in satellite measurements. We complement this method by analyzing the ion velocity distribution functions inside MHs. Our diagnostics reveal the presence of trapped gyrotropic ion populations, whose velocity distribution is consistent with a loss cone, as expected for the motion of particles inside a magnetic mirror. Our results have potential implications for the theoretical and numerical modeling of MHs.
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| 35. |
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| 36. |
- Bagdonaite, Ieva, et al.
(author)
-
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection
- 2023
-
In: Nature Communications. - 2041-1723. ; 14:1
-
Journal article (peer-reviewed)abstract
- Viral and host glycans represent an understudied aspect of host-pathogen interactions, despite potential implications for treatment of viral infections. This is due to lack of easily accessible tools for analyzing glycan function in a meaningful context. Here we generate a glycoengineered keratinocyte library delineating human glycosylation pathways to uncover roles of specific glycans at different stages of herpes simplex virus type 1 (HSV-1) infectious cycle. We show the importance of cellular glycosaminoglycans and glycosphingolipids for HSV-1 attachment, N-glycans for entry and spread, and O-glycans for propagation. While altered virion surface structures have minimal effects on the early interactions with wild type cells, mutation of specific O-glycosylation sites affects glycoprotein surface expression and function. In conclusion, the data demonstrates the importance of specific glycans in a clinically relevant human model of HSV-1 infection and highlights the utility of genetic engineering to elucidate the roles of specific viral and cellular carbohydrate structures.
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| 37. |
- Balk, Lennart, et al.
(author)
-
Widespread episodic thiamine deficiency in Northern Hemisphere wildlife
- 2016
-
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6
-
Journal article (peer-reviewed)abstract
- Many wildlife populations are declining at rates higher than can be explained by known threats to biodiversity. Recently, thiamine (vitamin B-1) deficiency has emerged as a possible contributing cause. Here, thiamine status was systematically investigated in three animal classes: bivalves, ray-finned fishes, and birds. Thiamine diphosphate is required as a cofactor in at least five life-sustaining enzymes that are required for basic cellular metabolism. Analysis of different phosphorylated forms of thiamine, as well as of activities and amount of holoenzyme and apoenzyme forms of thiaminedependent enzymes, revealed episodically occurring thiamine deficiency in all three animal classes. These biochemical effects were also linked to secondary effects on growth, condition, liver size, blood chemistry and composition, histopathology, swimming behaviour and endurance, parasite infestation, and reproduction. It is unlikely that the thiamine deficiency is caused by impaired phosphorylation within the cells. Rather, the results point towards insufficient amounts of thiamine in the food. By investigating a large geographic area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemical alterations to secondary effects, we demonstrate that the problem of thiamine deficiency is considerably more widespread and severe than previously reported.
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| 38. |
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| 39. |
- Battarbee, Markus, et al.
(author)
-
Helium in the Earth's foreshock : a global Vlasiator survey
- 2020
-
In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 38:5, s. 1081-1099
-
Journal article (peer-reviewed)abstract
- The foreshock is a region of space upstream of the Earth's bow shock extending along the interplanetary magnetic field (IMF). It is permeated by shock-reflected ions and electrons, low-frequency waves, and various plasma transients. We investigate the extent of the He2+ foreshock using Vlasiator, a global hybrid-Vlasov simulation. We perform the first numerical global survey of the helium foreshock and interpret some historical foreshock observations in a global context. The foreshock edge is populated by both proton and helium field-aligned beams, with the proton foreshock extending slightly further into the solar wind than the helium foreshock and both extending well beyond the ultra-low frequency (ULF) wave foreshock. We compare our simulation results with Magnetosphere Multiscale (MMS) Hot Plasma Composition Analyzer (HPCA) measurements, showing how the gradient of suprathermal ion densities at the foreshock crossing can vary between events. Our analysis suggests that the IMF cone angle and the associated shock obliquity gradient can play a role in explaining this differing behaviour. We also investigate wave-ion interactions with wavelet analysis and show that the dynamics and heating of He2+ must result from proton-driven ULF waves. Enhancements in ion agyrotropy are found in relation to, for example, the ion foreshock boundary, the ULF foreshock boundary, and specular reflection of ions at the bow shock. We show that specular reflection can describe many of the foreshock ion velocity distribution function (VDF) enhancements. Wave-wave interactions deep in the foreshock cause de-coherence of wavefronts, allowing He2+ to be scattered less than protons.
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| 40. |
- Beck, Olof, et al.
(author)
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Detectability of new psychoactive substances, 'legal highs', in CEDIA, EMIT, and KIMS immunochemical screening assays for drugs of abuse
- 2014
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In: Drug Testing and Analysis. - : Wiley. - 1942-7611 .- 1942-7603. ; 6:5, s. 492-499
-
Journal article (peer-reviewed)abstract
- The increasing number of new psychoactive substances made available for recreational drug use has created a challenge for clinical toxicology and drug testing laboratories. As a consequence, the routine immunoassay drug testing may become less effective due to an increased occurrence of false negative and false positive screening results. This work aimed to extend the knowledge about analytical cross-reactivity of new substances in selected CEDIA, EMIT, and KIMS immunoassays for drugs-of-abuse screening. Urine standards were prepared by spiking blank urine with 45 new substances. Authentic urine samples from intoxication cases identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) were also studied. Several new psychoactive substances were demonstrated to display cross-reactivity in the immunoassays. CEDIA Amphetamine/Ecstasy and EMIT d.a.u. Amphetamine Class tests showed the highest reactivity towards the new drugs, which was expected since many have amphetamine-like structure and activity. In the samples from authentic cases, five new substances displayed 100% detection rate in the CEDIA Amphetamine/Ecstasy test. In conclusion, cross-reactivity data in routine urine drug screening immunoassays for a number of new psychoactive substances not studied before were reported. In both spiked and authentic urine samples, some new substances showed significant cross-reactivity and are thus detectable in the routine screening methods. Copyright (c) 2014 John Wiley & Sons, Ltd.
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| 41. |
- Bengtsson, Hans, et al.
(author)
-
V2331 Cygni is an Algol Variable With Deep Eclipses
- 2013
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In: The Journal of the American Association of Variable Star Observers. - 2380-3606. ; 41:2, s. 264-266
-
Journal article (peer-reviewed)abstract
- We report the discovery that V2331 Cygni is not an L star but an eclipsing variable with deep minima, and present a determination of the elements of the star: Epoch = HJD 2456184.296 ±0.001 and Period = 1.3886 ± 0.0001 days.
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| 42. |
- Bergh, Tomas, et al.
(author)
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A resonant galvanically separated power MOSFET/IGBT gate driver
- 2004
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In: 2004 IEEE 35th Annual Power Electronics Specialists Conference. - 0780383990 ; , s. 3243-3247
-
Conference paper (peer-reviewed)abstract
- This paper provides a complete circuit for a low-loss non-conventional power MOSFET or IGBT driver. The driver, which provides galvanically separated input and output signals, is fed from a unipolar DC voltage but provides a bipolar gate-source voltage. The driver applies two, already known, techniques and together they form a resonant galvanically separated power MOSFET/IGBT gate driver. The first technique provides the galvanic separation, voltage level increase (or decrease) for the energy supply and signal transfer to the second technique. The second technique is the driver circuit, which is a resonant circuit that provides good driver properties. Together they form an inexpensive and non-complicated circuit, compared to conventional MOSFET or IGBT drivers. The use of expensive DC-DC converters is avoided and still bipolar gate voltages are provided
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| 43. |
- Bergh, Tomas, et al.
(author)
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Modeling and presentation of the series magnetized synchronous machine
- 2006
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In: International Symposium on Power Electronics, Electrical Drives, Automation and Motion, 2006. SPEEDAM 2006. ; 2006, s. 463-468
-
Conference paper (peer-reviewed)abstract
- In this paper mathematical modeling and a dedicated control algorithm of the patented Series Magnetized Synchronous Machine (SMSM) are presented. The SMSM is an electrically magnetized synchronous machine, where the field current is supplied via the stator windings and a diode bridge rectifier. For the SMSM there is no need for additional field voltage supply and the SMSM exhibits significantly faster field current dynamics than the Electrically magnetized synchronous machine (EMSM). Other additional benefits that follow are the possibility to utilize passive field weakening and simple sensor-less operation. The SMSM is in this case considered for an automotive application and therefore relates to the operating region of high rotational speed, low voltage and high current. This region of operation is considered to be the most challenging for this type of machine.
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| 44. |
- Berglund, David, et al.
(author)
-
Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials
- 2013
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In: Clinical and Experimental Immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 173:2, s. 310-322
-
Journal article (peer-reviewed)abstract
- Adoptive transfer of regulatory T cells (Tregs) has been proposed for use as a cellular therapy to induce transplantation tolerance. Preclinical data are encouraging, and clinical trials with Treg therapy are anticipated. In this study, we investigate different strategies for the isolation and expansion of CD4+CD25highCD127low Tregs from uraemic patients. We use allogeneic dendritic cells (DCs) as feeder cells for the expansion and compare Treg preparations isolated by either fluorescence activated cell sorting (FACS) or magnetic activated cell sorting (MACS) that have been expanded subsequently with either mature or tolerogenic DCs. Expanded Treg preparations have been characterized by their purity, cytokine production and in-vitro suppressive ability. The results show that Treg preparations can be isolated from uraemic patients by both FACS and MACS. Also, the type of feeder cells used in the expansion affects both the purity and the functional properties of the Treg preparations. In particular, FACS-sorted Treg preparations expanded with mature DCs secrete more interleukin (IL)-10 and granzyme B than FACS-sorted Treg preparations expanded with tolerogenic DCs. This is a direct comparison between different isolation techniques and expansion protocols with Tregs from uraemic patients that may guide future efforts to produce clinical-grade Tregs for use in kidney transplantation.
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| 45. |
- Blikstad, Mathias, et al.
(author)
-
A constraint generation procedure for pre-runtime scheduling of integrated modular avionic systems
- 2017
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In: Proceedings of the 13th Workshop on Models and Algorithms for Planning and Scheduling Problems.
-
Conference paper (other academic/artistic)abstract
- In modern integrated modular avionic systems, applications share hardware resources on a common avionic platform. Such an architecture necessitates strict requirements on the spatial and temporal partitioning of the system to prevent fault propagation between different aircraft functions. One way to establish a temporal partitioning is through pre-runtime scheduling of the system, which involves creating a schedule for both tasks and a communication network.While the avionic systems are growing more and more complex, so is the challenge of scheduling them. Scheduling of the system has an important role in the development of new avionic systems since functionality typically is added to the system over a period of several years and a scheduling tool is used both to detect if the platform can host the new functionality and, in case this is possible, to create a new schedule. For this reason an exact solution strategy for avionics scheduling is preferred over a heuristic one.In this paper we present a mathematical model for an industrially relevant avionic system and present a constraint generation procedure for scheduling of such systems. We apply our optimisation approach to instances provided by our industrial partner. These instances are of relevance for the development of future avionic systems and contain up to 20 000 tasks to be scheduled. The computational results show that our optimisation approach can be used to create schedules for such instances within reasonable time.
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| 46. |
- Blikstad, Mathias, et al.
(author)
-
An Optimisation Approach for Pre-Runtime Scheduling of Tasks and Communication in an Integrated Modular Avionic System
- 2017
-
Reports (other academic/artistic)abstract
- In modern integrated modular avionic systems, applications share hardware resources on a common avionic platform. Such an architecture necessitates strict requirements on the spatial and temporal partitioning of the system to prevent fault propagation between different aircraft functions. One way to establish a temporal partitioning is through pre-runtime scheduling of the system, which involves creating a schedule for both tasks and a communication network.While the avionic systems are growing more and more complex, so is the challenge of scheduling them. Scheduling of the system has an important role in the development of new avionic systems since functionality typically is added to the system over a period of several years and a scheduling tool is used both to detect if the platform can host the new functionality and, in case this is possible, to create a new schedule. For this reason an exact solution strategy for avionics scheduling is preferred over a heuristic one.In this paper we present a mathematical model for an industrially relevant avionic system and present a constraint generation procedure for scheduling of such systems. We apply our optimisation approach to instances provided by our industrial partner. These instances are of relevance for the development of future avionic systems and contain up to 20 000 tasks to be scheduled. The computational results show that our optimisation approach can be used to create schedules for such instances within reasonable time.
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| 47. |
- Blikstad, Mathias, et al.
(author)
-
An optimisation approach for pre-runtime scheduling of tasks and communication in an integrated modular avionic system
- 2018
-
In: Optimization and Engineering. - : Springer Science and Business Media LLC. - 1389-4420 .- 1573-2924. ; 19:4, s. 977-1004
-
Journal article (peer-reviewed)abstract
- In modern integrated modular avionic systems, applications share hardware resources on a common avionic platform. Such an architecture necessitates strict requirements on the spatial and temporal partitioning of the system to prevent fault propagation between different aircraft functions. One way to establish a temporal partitioning is through pre-runtime scheduling of the system, which involves creating a schedule for both tasks and a communication network. While avionic systems are growing more and more complex, so is the challenge of scheduling them. The scheduling of the system has an important role in the development of new avionic systems, since functionality is typically added to the system over a period of several years and a scheduling tool is used both to detect if the platform can host the new functionality and, if this is possible, to create a new schedule. For this reason an exact solution strategy for avionics scheduling is preferred over a heuristic one. In this paper we present a mathematical model for an industrially relevant avionic system and present a constraint generation procedure for the scheduling of such systems. We apply our optimisation approach to instances provided by our industrial partner. These instances are of relevance for the development of future avionic systems and contain up to 20,000 tasks to be scheduled. The computational results show that our optimisation approach can be used to create schedules for such instances within a reasonable time.
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| 48. |
- Blomberg, Lars G., et al.
(author)
-
EMMA - the electric and magnetic monitor of the aurora on Astrid-2
- 2004
-
In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 22:1, s. 115-123
-
Journal article (peer-reviewed)abstract
- The Astrid-2 mission has dual primary objectives. First, it is an orbiting instrument platform for studying auroral electrodynamics. Second, it is a technology demonstration of the feasibility of using micro-satellites for innovative space plasma physics research. The EMMA instrument, which we discuss in the present paper, is designed to provide simultaneous sampling of two electric and three magnetic field components up to about 1 kHz. The spin plane components of the electric field are measured by two pairs of opposing probes extended by wire booms with a separation distance of 6.7 m. The probes have titanium nitride (TiN) surfaces. which has proved to be a material with excellent properties for providing good electrical contact between probe and plasma. The wire booms are of a new design in which the booms in the stowed position are wound around the exterior of the spacecraft body. The boom system was flown for the first time on this mission and worked flawlessly. The magnetic field is measured by a tri-axial fluxgate sensor located at the tip of a rigid. hinged boom extended along the spacecraft spin axis and facing away from the Sun. The new advanced-design fluxgate magnetometer uses digital signal processors for detection and feedback, thereby reducing the analogue circuitry to a minimum. The instrument characteristics as well as a brief review of the science accomplished and planned are presented.
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| 49. |
- Blomberg, Lars G., et al.
(author)
-
Solar windmagnetosphere-ionosphere coupling : an event study based on Freja data
- 2004
-
In: Journal of Atmospheric and Solar-Terrestrial Physics. - : Elsevier BV. - 1364-6826 .- 1879-1824. ; 66:5, s. 375-380
-
Journal article (peer-reviewed)abstract
- Freja data are used to study the relative contributions from the high-latitude (reconnection/direct entry) and low-latitude (viscous interaction) dynamos to the cross-polar potential drop. Convection streamlines which are connected to the high-latitude dynamo may be identified from dispersed magnetosheath ions not only in the cusp/cleft region itself but also several degrees poleward of it. This fact, together with Freja's orbital geometry allows us to infer the potential drop from the high-latitude dynamo as well as to obtain a lower limit to the potential drop from the low-latitude dynamo for dayside Freja passes. All cases studied here are for active magnetospheric conditions. The Freja data suggest that under these conditions at least one third of the potential is generated in the low-latitude dynamo. These observations are consistent with earlier observations of the potential across the low-latitude boundary layer if we assume that the low-latitude dynamo region extends over several tens of Earth radii in the antisunward direction along the tail flanks, and that the majority of the potential drop derives from the sun-aligned component of the electric field rather than from its cross-boundary component, or equivalently, that the centre of the dynamo region is located quite far down tail. A possible dynamo geometry is illustrated.
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| 50. |
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