| 1. |
- Amiri, M., et al.
(author)
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Periodic activity from a fast radio burst source
- 2020
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 582:7812, s. 351-355
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Journal article (peer-reviewed)abstract
- Fast radio bursts (FRBs) are bright, millisecond-duration radio transients originating from sources at extragalactic distances1, the origin of which is unknown. Some FRB sources emit repeat bursts, ruling out cataclysmic origins for those events2–4. Despite searches for periodicity in repeat burst arrival times on timescales from milliseconds to many days2,5–7, these bursts have hitherto been observed to appear sporadically and—although clustered8—without a regular pattern. Here we report observations of a 16.35 ± 0.15 day periodicity (or possibly a higher-frequency alias of that periodicity) from the repeating FRB 180916.J0158+65 detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project4,9. In 38 bursts recorded from 16 September 2018 to 4 February 2020 utc, we find that all bursts arrive in a five-day phase window, and 50 per cent of the bursts arrive in a 0.6-day phase window. Our results suggest a mechanism for periodic modulation either of the burst emission itself or through external amplification or absorption, and disfavour models invoking purely sporadic processes.
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| 2. |
- Kirsten, Franz, 1983, et al.
(author)
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A repeating fast radio burst source in a globular cluster
- 2022
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 602:7898, s. 585-589
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Journal article (peer-reviewed)abstract
- Fast radio bursts (FRBs) are flashes of unknown physical origin1. The majority of FRBs have been seen only once, although some are known to generate multiple flashes2,3. Many models invoke magnetically powered neutron stars (magnetars) as the source of the emission4,5. Recently, the discovery6 of another repeater (FRB 20200120E) was announced, in the direction of the nearby galaxy M81, with four potential counterparts at other wavelengths6. Here we report observations that localized the FRB to a globular cluster associated with M81, where it is 2 parsecs away from the optical centre of the cluster. Globular clusters host old stellar populations, challenging FRB models that invoke young magnetars formed in a core-collapse supernova. We propose instead that FRB 20200120E originates from a highly magnetized neutron star formed either through the accretion-induced collapse of a white dwarf, or the merger of compact stars in a binary system7. Compact binaries are efficiently formed inside globular clusters, so a model invoking them could also be responsible for the observed bursts.
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| 3. |
- Scholz, P., et al.
(author)
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Simultaneous X-Ray and Radio Observations of the Repeating Fast Radio Burst FRB similar to 180916.J0158+65
- 2020
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In: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 901:2
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Journal article (peer-reviewed)abstract
- We report on simultaneous radio and X-ray observations of the repeating fast radio burst source FRB 180916.J0158+65 using the Canadian Hydrogen Intensity Mapping Experiment (CHIME), Effelsberg, and Deep Space Network (DSS-14 and DSS-63) radio telescopes and the Chandra X-ray Observatory. During 33 ks of Chandra observations, we detect no radio bursts in overlapping Effelsberg or Deep Space Network observations and a single burst during CHIME/FRB source transits. We detect no X-ray events in excess of the background during the Chandra observations. These non-detections imply a 5 sigma limit of <5 x 10(-10)erg cm(-2)for the 0.5-10 keV fluence of prompt emission at the time of the radio burst and 1.3 x 10(-9)erg cm(-2)at any time during the Chandra observations. Given the host-galaxy redshift of FRB 180916.J0158+65 (z similar to 0.034), these correspond to energy limits of <1.6 x 10(45)erg and <4 x 10(45)erg, respectively. We also place a 5 sigma limit of <8 x 10(-15)erg s(-1) cm(-2)on the 0.5-10 keV absorbed flux of a persistent source at the location of FRB 180916.J0158+65. This corresponds to a luminosity limit of <2 x 10(40)erg s(-1). Using an archival set of radio bursts from FRB 180916.J0158+65, we search for prompt gamma-ray emission in Fermi/GBM data but find no significant gamma-ray bursts, thereby placing a limit of 9 x 10(-9)erg cm(-2)on the 10-100 keV fluence. We also search Fermi/LAT data for periodic modulation of the gamma-ray brightness at the 16.35 days period of radio burst activity and detect no significant modulation. We compare these deep limits to the predictions of various fast radio burst models, but conclude that similar X-ray constraints on a closer fast radio burst source would be needed to strongly constrain theory.
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| 4. |
- Marcote, B., et al.
(author)
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A repeating fast radio burst source localized to a nearby spiral galaxy
- 2020
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 577:7789, s. 190-194
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Journal article (peer-reviewed)abstract
- Fast radio bursts (FRBs) are brief, bright, extragalactic radio flashes1,2. Their physical origin remains unknown, but dozens of possible models have been postulated3. Some FRB sources exhibit repeat bursts4–7. Although over a hundred FRB sources have been discovered8, only four have been localized and associated with a host galaxy9–12, and just one of these four is known to emit repeating FRBs9. The properties of the host galaxies, and the local environments of FRBs, could provide important clues about their physical origins. The first known repeating FRB, however, was localized to a low-metallicity, irregular dwarf galaxy, and the apparently non-repeating sources were localized to higher-metallicity, massive elliptical or star-forming galaxies, suggesting that perhaps the repeating and apparently non-repeating sources could have distinct physical origins. Here we report the precise localization of a second repeating FRB source6, FRB 180916.J0158+65, to a star-forming region in a nearby (redshift 0.0337 ± 0.0002) massive spiral galaxy, whose properties and proximity distinguish it from all known hosts. The lack of both a comparably luminous persistent radio counterpart and a high Faraday rotation measure6 further distinguish the local environment of FRB 180916.J0158+65 from that of the single previously localized repeating FRB source, FRB 121102. This suggests that repeating FRBs may have a wide range of luminosities, and originate from diverse host galaxies and local environments.
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| 5. |
- Nimmo, K., et al.
(author)
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Burst timescales and luminosities as links between young pulsars and fast radio bursts
- 2022
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In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 6:3, s. 393-401
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Journal article (peer-reviewed)abstract
- Fast radio bursts (FRBs) are extragalactic radio flashes of unknown physical origin. Their high luminosities and short durations require extreme energy densities, such as those found in the vicinity of neutron stars and black holes. Studying the burst intensities and polarimetric properties on a wide range of timescales, from milliseconds down to nanoseconds, is key to understanding the emission mechanism. However, high-time-resolution studies of FRBs are limited by their unpredictable activity levels, available instrumentation and temporal broadening in the intervening ionized medium. Here we show that the repeating FRB 20200120E can produce isolated shots of emission as short as about 60 nanoseconds in duration, with brightness temperatures as high as 3 × 1041 K (excluding relativistic effects), comparable with ‘nano-shots’ from the Crab pulsar. Comparing both the range of timescales and luminosities, we find that FRB 20200120E observationally bridges the gap between known Galactic young pulsars and magnetars and the much more distant extragalactic FRBs. This suggests a common magnetically powered emission mechanism spanning many orders of magnitude in timescale and luminosity. In this Article, we probe a relatively unexplored region of the short-duration transient phase space; we highlight that there probably exists a population of ultrafast radio transients at nanosecond to microsecond timescales, which current FRB searches are insensitive to.
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| 6. |
- Nimmo, K., et al.
(author)
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Milliarcsecond Localization of the Repeating FRB 20201124A
- 2022
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 927:1
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Journal article (peer-reviewed)abstract
- Very long baseline interferometric (VLBI) localizations of repeating fast radio bursts (FRBs) have demonstrated a diversity of local environments: from nearby star-forming regions to globular clusters. Here we report the VLBI localization of FRB 20201124A using an ad hoc array of dishes that also participate in the European VLBI Network (EVN). In our campaign, we detected 18 bursts from FRB 20201124A at two separate epochs. By combining the visibilities from both epochs, we were able to localize FRB 20201124A with a 1 sigma uncertainty of 2.7 mas. We use the relatively large burst sample to investigate astrometric accuracy and find that for greater than or similar to 20 baselines (greater than or similar to 7 dishes) we can robustly reach milliarcsecond precision even using single-burst data sets. Subarcsecond precision is still possible for single bursts, even when only similar to 6 baselines (four dishes) are available. In such cases, the limited uv coverage for individual bursts results in very high side-lobe levels. Thus, in addition to the peak position from the dirty map, we also explore smoothing the structure in the dirty map by fitting Gaussian functions to the fringe pattern in order to constrain individual burst positions, which we find to be more reliable. Our VLBI work places FRB 20201124A 710 +/- 30 mas (1 sigma uncertainty) from the optical center of the host galaxy, consistent with originating from within the recently discovered extended radio structure associated with star formation in the host galaxy. Future high-resolution optical observations, e.g., with Hubble Space Telescope, can determine the proximity of FRB 20201124A's position to nearby knots of star formation.
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| 7. |
- Pleunis, Z., et al.
(author)
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LOFAR Detection of 110-188MHz emission and frequency-dependent activity from FRB20180916B
- 2021
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
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Journal article (peer-reviewed)abstract
- The object FRB 20180916B is a well-studied repeating fast radio burst source. Its proximity (∼150 Mpc), along with detailed studies of the bursts, has revealed many clues about its nature, including a 16.3 day periodicity in its activity. Here we report on the detection of 18 bursts using LOFAR at 110-188 MHz, by far the lowest-frequency detections of any FRB to date. Some bursts are seen down to the lowest observed frequency of 110 MHz, suggesting that their spectra extend even lower. These observations provide an order-of-magnitude stronger constraint on the optical depth due to freëCfree absorption in the source's local environment. The absence of circular polarization and nearly flat polarization angle curves are consistent with burst properties seen at 300-1700 MHz. Compared with higher frequencies, the larger burst widths (∼40-160 ms at 150 MHz) and lower linear polarization fractions are likely due to scattering. We find ∼2-3 rad m variations in the Faraday rotation measure that may be correlated with the activity cycle of the source. We compare the LOFAR burst arrival times to those of 38 previously published and 22 newly detected bursts from the uGMRT (200-450 MHz) and CHIME/FRB (400-800 MHz). Simultaneous observations show five CHIME/FRB bursts when no emission is detected by LOFAR. We find that the burst activity is systematically delayed toward lower frequencies by about 3 days from 600 to 150 MHz. We discuss these results in the context of a model in which FRB 20180916B is an interacting binary system featuring a neutron star and high-mass stellar companion.
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| 8. |
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| 9. |
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| 10. |
- Hewitt, Dante M., et al.
(author)
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Milliarcsecond localization of the hyperactive repeating FRB 20220912A
- 2024
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In: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 529:2, s. 1814-1826
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Journal article (peer-reviewed)abstract
- We present very long-baseline interferometry (VLBI) observations of the hyperactive repeating FRB 20220912A using the European VLBI Network (EVN) outside of regular observing sessions (EVN-Lite). We detected 150 bursts from FRB 20220912A over two observing epochs in 2022 October. Combining the burst data allows us to localize FRB 20220912A to a precision of a few milliarcseconds, corresponding to a transverse scale of less than 10 pc at the distance of the source. This precise localization shows that FRB 20220912A lies closer to the centre of its host galaxy than previously found, although still significantly offset from the host galaxy's nucleus. On arcsecond scales, FRB 20220912A is coincident with a persistent continuum radio source known from archival observations; however, we find no compact persistent emission on milliarcsecond scales. The 5σ upper limit on the presence of such a compact persistent radio source is 120 μJy, corresponding to a luminosity limit of (D/362.4 Mpc)erg s-1 Hz-1. The persistent radio emission is thus likely to be from star formation in the host galaxy. This is in contrast to some other active FRBs, such as FRB 20121102A and FRB 20190520B.
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| 11. |
- Keimpema, A., et al.
(author)
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The SFXC software correlator for very long baseline interferometry: algorithms and implementation
- 2015
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In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 39:2, s. 259-279
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Journal article (peer-reviewed)abstract
- In this paper a description is given of the SFXC software correlator, developed and maintained at the Joint Institute for VLBI in Europe (JIVE). The software is designed to run on generic Linux-based computing clusters. The correlation algorithm is explained in detail, as are some of the novel modes that software correlation has enabled, such as wide-field VLBI imaging through the use of multiple phase centres and pulsar gating and binning. This is followed by an overview of the software architecture. Finally, the performance of the correlator as a function of number of CPU cores, telescopes and spectral channels is shown.
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| 12. |
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| 13. |
- Nimmo, K., et al.
(author)
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Highly polarized microstructure from the repeating FRB 20180916B
- 2021
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In: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 5:6, s. 594-603
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Journal article (peer-reviewed)abstract
- Fast radio bursts (FRBs) are bright, coherent, short-duration radio transients of as-yet unknown extragalactic origin. FRBs exhibit a variety of spectral, temporal and polarimetric properties that can unveil clues into their emission physics and propagation effects in the local medium. Here, we present the high-time-resolution (down to 1 mu s) polarimetric properties of four 1.7 GHz bursts from the repeating FRB 20180916B, which were detected in voltage data during observations with the European Very Long Baseline Interferometry Network. We observe a range of emission timescales that spans three orders of magnitude, with the shortest component width reaching 3-4 mu s (below which we are limited by scattering). We demonstrate that all four bursts are highly linearly polarized (greater than or similar to 80%), show no evidence of significant circular polarization (less than or similar to 15%), and exhibit a constant polarization position angle (PPA) during and between bursts. On short timescales (less than or similar to 100 mu s), however, there appear to be subtle PPA variations (of a few degrees) across the burst profiles. These observational results are most naturally explained in an FRB model in which the emission is magnetospheric in origin, in contrast to models in which the emission originates at larger distances in a relativistic shock. High-time-resolution observations of the repeating fast radio burst source FRB 20180916B reveal changes to the polarization properties of the emission on timescales of a few microseconds, indicating an origin in the source magnetosphere.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- Korchynska, Solomiia, et al.
(author)
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Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants
- 2020
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In: EMBO Journal. - : EMBO. - 1460-2075 .- 0261-4189. ; 39:1
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Journal article (peer-reviewed)abstract
- Maternal drug abuse during pregnancy is a rapidly escalating societal problem. Psychostimulants, including amphetamine, cocaine, and methamphetamine, are amongst the illicit drugs most commonly consumed by pregnant women. Neuropharmacology concepts posit that psychostimulants affect monoamine signaling in the nervous system by their affinities to neurotransmitter reuptake and vesicular transporters to heighten neurotransmitter availability extracellularly. Exacerbated dopamine signaling is particularly considered as a key determinant of psychostimulant action. Much less is known about possible adverse effects of these drugs on peripheral organs, and if in utero exposure induces lifelong pathologies. Here, we addressed this question by combining human RNA-seq data with cellular and mouse models of neuroendocrine development. We show that episodic maternal exposure to psychostimulants during pregnancy coincident with the intrauterine specification of pancreatic β cells permanently impairs their ability of insulin production, leading to glucose intolerance in adult female but not male offspring. We link psychostimulant action specifically to serotonin signaling and implicate the sex-specific epigenetic reprogramming of serotonin-related gene regulatory networks upstream from the transcription factor Pet1/Fev as determinants of reduced insulin production.
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| 20. |
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| 21. |
- Romanov, Roman A., et al.
(author)
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Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
- 2017
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In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 20:2, s. 176-188
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Journal article (peer-reviewed)abstract
- The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S+ neurons of the suprachiasmatic nucleus. These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S+ inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. Overall, our catalog of neuronal subclasses provides new understanding of. hypothalamic organization and function.
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| 22. |
- Tornatore, Vincenza, et al.
(author)
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Single baseline GLONASS observations with VLBI: data processing and first results
- 2011
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In: Proceedings of the 20th Meeting of the European VLBI Group for Geodesy and Astrometry. - 1864-1113. ; , s. 162-165
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Conference paper (other academic/artistic)abstract
- The VLBI technique, in geodetic mode, was used to observe signals emitted by three GLONASS (GLObal NAvigationSatellite System) satellites. The baseline observing simultaneously satellites had at its ends the Medicina (32 m) and Onsala85 (25 m) radio telescopes, both equipped with L-band receivers. Several preparatory tests were necessary for obtaining good data that could be processed. In this paper we report on the observations performed on August 16, 2010 data processing and results of the experiment. The natural radio source 3c286 was observed also as a calibrator before and after satellite observing sessions. A narrow band approach using software primarily developed for astronomical and space applications, was applied to extract the narrow band carrier. Differential frequency on the baseline Medicina-Onsala was also evaluated to compute differential phase which was then adopted to determine satellite coordinate corrections with respect to ITRFvalues. Broad-band correlation was performed on the calibrator data using the DiFX software. The SFXC correlation of satellite data was performed testing near field delay model at extreme nearness; obtained results are described.
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| 23. |
- Tortoriello, Giuseppe, et al.
(author)
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Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster
- 2021
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In: Cannabis and cannabinoid research. - : Mary Ann Liebert. - 2578-5125 .- 2378-8763. ; 6:2, s. 119-136
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Journal article (peer-reviewed)abstract
- Introduction: In mammals, sn-1-diacylglycerol lipases (DAGL) generate 2-arachidonoylglycerol (2-AG) that, as the major endocannabinoid, modulates synaptic neurotransmission by acting on CB1 cannabinoid receptors (CB1R). Even though the insect genome codes for inaE, which is a DAGL ortholog (dDAGL), its products and their functions remain unknown particularly because insects lack chordate-type cannabinoid receptors. Materials and Methods: Gain-of-function and loss-of-function genetic manipulations were carried out in Drosophila melanogaster, including the generation of both dDAGL-deficient and mammalian CB1R-overexpressing flies. Neuroanatomy, dietary manipulations coupled with targeted mass spectrometry determination of arachidonic acid and 2-linoleoyl glycerol (2-LG) production, behavioral assays, and signal transduction profiling for Akt and Erk kinases were employed. Findings from Drosophilae were validated by a CB1R-binding assay for 2-LG in mammalian cortical homogenates with functionality confirmed in neurons using high-throughput real-time imaging in vitro. Results: In this study, we show that dDAGL is primarily expressed in the brain and nerve cord of Drosophila during larval development and in adult with 2-LG being its chief product as defined by dietary precursor availability. Overexpression of the human CB1R in the ventral nerve cord compromised the mobility of adult Drosophilae. The causality of 2-LG signaling to CB1R-induced behavioral impairments was shown by inaE inactivation normalizing defunct motor coordination. The 2-LG-induced activation of transgenic CB(1)Rs affected both Akt and Erk kinase cascades by paradoxical signaling. Data from Drosophila models were substantiated by showing 2-LG-mediated displacement of [H-3]CP 55,940 in mouse cortical homogenates and reduced neurite extension and growth cone collapsing responses in cultured mouse neurons. Conclusions: Overall, these results suggest that 2-LG is an endocannabinoid-like signal lipid produced by dDAGL in Drosophila.
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| 24. |
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