| 1. |
|
|
| 2. |
- Yoo, Taekyeong, et al.
(author)
-
Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease.
- 2021
-
In: Journal of hepatology. - : Elsevier BV. - 1600-0641 .- 0168-8278. ; 75:3, s. 514-523
-
Journal article (peer-reviewed)abstract
- Nonalcoholic fatty liver disease (NAFLD) poses an impending clinical burden. Genome-wide association studies have revealed a limited contribution of genomic variants to the disease, requiring alternative but robust approaches to identify disease-associated variants and genes. We carried out a disease-specific expression quantitative trait loci (eQTL) screen to identify novel genetic factors that specifically act on NAFLD progression on the basis of genotype.We recruited 125 Korean biopsy-proven NAFLD patients and healthy individuals and performed eQTL analyses using 21,272 transcripts and 3,234,941 genotyped and imputed SNPs. We then selected eQTLs that were detected only in the NAFLD group, but not in the control group (i.e., NAFLD-eQTLs). An additional cohort of 162 Korean NAFLD individuals was used for replication. The function of the selected eQTL toward NAFLD development was validated using HepG2, primary hepatocytes and NAFLD mouse models.The NAFLD-specific eQTL screening yielded 242 loci. Among them, AGXT2, encoding alanine-glyoxylate aminotransferase 2, displayed decreased expression in NAFLD patients homozygous for the non-reference allele of rs2291702, compared to no-NAFLD subjects with the same genotype (P = 4.79 × 10-6). This change was replicated in an additional 162 individuals, yielding a combined P-value of 8.05 × 10-8 from a total of 245 NAFLD patients and 48 controls. Knockdown of AGXT2 induced palmitate-overloaded hepatocyte death by increasing ER stress, and exacerbated NAFLD diet-induced liver fibrosis in mice. However, overexpression of AGXT2 reversely attenuated liver fibrosis and steatosis as well.We implicate a new molecular role of AGXT2 in NAFLD. Our overall approach will serve as an efficient tool for uncovering novel genetic factors that contribute to liver steatosis and fibrosis in patients with NAFLD.Elucidating causal genes for NAFLD has been challenging due to limited tissue availability and the polygenic nature of the disease. Using liver and blood samples from 125 biopsy-proven NAFLD and no-NAFLD Korean individuals and an additional 162 individuals for replication, we devised a new analytic method to identify causal genes. Among the candidates, we found that AGXT2-rs2291702 protects against liver fibrosis in a genotype-dependent manner with the potential for therapeutic interventions. Our approach enables the discovery of NAFLD causal genes that act on the basis of genotype.
|
|
| 3. |
- Kim, Se-Hoon, et al.
(author)
-
Nanophase oxalate precursors of thermoelectric CoSb3 by controlled coprecipitation predicted by thermodynamic modeling
- 2016
-
In: Advanced Powder Technology. - : Elsevier. - 0921-8831 .- 1568-5527. ; 27:2, s. 773-778
-
Journal article (peer-reviewed)abstract
- The precursors for the formation of thermoelectric skutterudite CoSb3 nanoparticles are predicted by thermodynamic modeling of the complex chemical species. Based on the results, equimolar mixture of CoC2O4 center dot 2H(2)O and Sb(C2O4) OH are successively co-precipitated under controlled conditions of pH = 2.7 and concentration of reactants. The as synthesized powder was decomposed at 350 degrees C to remove the organic molecules and further reduced to CoSb3 phase by heating at 530 degrees C under hydrogen flow. The obtained powder was consolidated by spark plasma sintering (SPS). CoSb3 prepared by controlled chemical co-precipitation has p-type behavior with a positive sign of the Seebeck coefficient. TE transport properties were measured, which revealed that the Seebeck coefficient increased 2.5 times with increasing the temperature and it is lower than the ball milled CoSb3. Thermal conductivity of sintered CoSb3 at 773 K starts from 0.06 W/cm K at room temperature and decreases to 0.04 W/cm K at 700 K, which is lower than the bulk counterpart. The ZT of coprecipitated CoSb3 and SPS consolidated at 773 K shows 2 times higher than the ball milled one. (C) 2016 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
|
|
| 4. |
- Birney, Ewan, et al.
(author)
-
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
-
Journal article (peer-reviewed)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
|
|
| 5. |
- Chen, Ziming, et al.
(author)
-
Roadmap on perovskite light-emitting diodes
- 2024
-
In: JOURNAL OF PHYSICS-PHOTONICS. - : IOP Publishing Ltd. - 2515-7647. ; 6:3
-
Journal article (peer-reviewed)abstract
- In recent years, the field of metal-halide perovskite emitters has rapidly emerged as a new community in solid-state lighting. Their exceptional optoelectronic properties have contributed to the rapid rise in external quantum efficiencies (EQEs) in perovskite light-emitting diodes (PeLEDs) from <1% (in 2014) to over 30% (in 2023) across a wide range of wavelengths. However, several challenges still hinder their commercialization, including the relatively low EQEs of blue/white devices, limited EQEs in large-area devices, poor device stability, as well as the toxicity of the easily accessible lead components and the solvents used in the synthesis and processing of PeLEDs. This roadmap addresses the current and future challenges in PeLEDs across fundamental and applied research areas, by sharing the community's perspectives. This work will provide the field with practical guidelines to advance PeLED development and facilitate more rapid commercialization.
|
|
| 6. |
- Cheon, Hwanju, et al.
(author)
-
Role of JNK activation in pancreatic β-cell death by streptozotocin
- 2010
-
In: Molecular and Cellular Endocrinology. - 0303-7207. ; 321:2, s. 131-137
-
Journal article (peer-reviewed)abstract
- c-Jun N-terminal kinase (JNK) is activated by cellular stress and plays critical roles in diverse types of cell death. However, role of JNK in β-cell injury is obscure. We investigated the role for JNK in streptozotocin (STZ)-induced β-cell death. STZ induced JNK activation in insulinoma or islet cells. JNK inhibitors attenuated insulinoma or islet cell death by STZ. STZ-induced JNK activation was decreased by PARP inhibitors, suggesting that JNK activation is downstream of PARP-1. Phosphatase inhibitors induced activation of JNK and abrogated the suppression of STZ-induced JNK activation by PARP inhibitors, suggesting that the inhibition of phosphatases is involved in the activation of JNK by STZ. STZ induced production of reactive oxygen species (ROS) as potential inhibitors of phosphatases, which was suppressed by PARP inhibitors. PARP-1 siRNA attenuated insulinoma cell death and JNK activation after STZ treatment, which was reversed by MKP (MAP kinase phosphatase)-1 siRNA. These results suggest that JNK is activated by STZ downstream of PARP-1 through inactivation of phosphatases such as MKP, which plays important roles in STZ-induced β-cell death.
|
|
| 7. |
- Cheon, Jae Yeong, et al.
(author)
-
Ordered mesoporous porphyrinic carbons with very high electrocatalytic activity for the oxygen reduction reaction
- 2013
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 3, s. 2715-
-
Journal article (peer-reviewed)abstract
- The high cost of the platinum-based cathode catalysts for the oxygen reduction reaction (ORR) has impeded the widespread application of polymer electrolyte fuel cells. We report on a new family of non-precious metal catalysts based on ordered mesoporous porphyrinic carbons (M-OMPC; M = Fe, Co, or FeCo) with high surface areas and tunable pore structures, which were prepared by nanocasting mesoporous silica templates with metalloporphyrin precursors. The FeCo-OMPC catalyst exhibited an excellent ORR activity in an acidic medium, higher than other non-precious metal catalysts. It showed higher kinetic current at 0.9 V than Pt/C catalysts, as well as superior long-term durability and MeOH-tolerance. Density functional theory calculations in combination with extended X-ray absorption fine structure analysis revealed a weakening of the interaction between oxygen atom and FeCo-OMPC compared to Pt/C. This effect and high surface area of FeCo-OMPC appear responsible for its significantly high ORR activity.
|
|
| 8. |
- Kariippanon, Katharina E., et al.
(author)
-
Levels and Correlates of Objectively Measured Sedentary Behavior in Young Children : SUNRISE Study Results from 19 Countries
- 2022
-
In: Medicine & Science in Sports & Exercise. - : Lippincott, Williams & Wilkins. - 0195-9131 .- 1530-0315. ; 54:7, s. 1123-1130
-
Journal article (peer-reviewed)abstract
- Purpose There is a paucity of global data on sedentary behavior during early childhood. The purpose of this study was to examine how device-measured sedentary behavior in young children differed across geographically, economically, and sociodemographically diverse populations, in an international sample. Methods This multinational, cross-sectional study included data from 1071 children 3-5 yr old from 19 countries, collected between 2018 and 2020 (pre-COVID). Sedentary behavior was measured for three consecutive days using activPAL accelerometers. Sedentary time, sedentary fragmentation, and seated transport duration were calculated. Linear mixed models were used to examine the differences in sedentary behavior variables between sex, country-level income groups, urban/rural settings, and population density. Results Children spent 56% (7.4 h) of their waking time sedentary. The longest average bout duration was 81.1 +/- 45.4 min, and an average of 61.1 +/- 50.1 min center dot d(-1) was spent in seated transport. Children from upper-middle-income and high-income countries spent a greater proportion of the day sedentary, accrued more sedentary bouts, had shorter breaks between sedentary bouts, and spent significantly more time in seated transport, compared with children from low-income and lower-middle-income countries. Sex and urban/rural residential setting were not associated with any outcomes. Higher population density was associated with several higher sedentary behavior measures. Conclusions These data advance our understanding of young childrens sedentary behavior patterns globally. Country income levels and population density appear to be stronger drivers of the observed differences, than sex or rural/urban residential setting.
|
|
| 9. |
- Okely, Anthony D., et al.
(author)
-
Cross-sectional examination of 24-hour movement behaviours among 3-and 4-year-old children in urban and rural settings in low-income, middle-income and high-income countries : the SUNRISE study protocol
- 2021
-
In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 11:10
-
Journal article (peer-reviewed)abstract
- Introduction 24-hour movement behaviours (physical activity, sedentary behaviour and sleep) during the early years are associated with health and developmental outcomes, prompting the WHO to develop Global guidelines for physical activity, sedentary behaviour and sleep for children under 5 years of age. Prevalence data on 24-hour movement behaviours is lacking, particularly in low-income and middle-income countries (LMICs). This paper describes the development of the SUNRISE International Study of Movement Behaviours in the Early Years protocol, designed to address this gap. Methods and analysis SUNRISE is the first international cross-sectional study that aims to determine the proportion of 3- and 4-year-old children who meet the WHO Global guidelines. The study will assess if proportions differ by gender, urban/rural location and/or socioeconomic status. Executive function, motor skills and adiposity will be assessed and potential correlates of 24-hour movement behaviours examined. Pilot research from 24 countries (14 LMICs) informed the study design and protocol. Data are collected locally by research staff from partnering institutions who are trained throughout the research process. Piloting of all measures to determine protocol acceptability and feasibility was interrupted by COVID-19 but is nearing completion. At the time of publication 41 countries are participating in the SUNRISE study. Ethics and dissemination The SUNRISE protocol has received ethics approved from the University of Wollongong, Australia, and in each country by the applicable ethics committees. Approval is also sought from any relevant government departments or organisations. The results will inform global efforts to prevent childhood obesity and ensure young children reach their health and developmental potential. Findings on the correlates of movement behaviours can guide future interventions to improve the movement behaviours in culturally specific ways. Study findings will be disseminated via publications, conference presentations and may contribute to the development of local guidelines and public health interventions.
|
|
| 10. |
- Weinstein, John N., et al.
(author)
-
The cancer genome atlas pan-cancer analysis project
- 2013
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
-
Research review (peer-reviewed)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
|
|
| 11. |
- Chen, Deliang, 1961, et al.
(author)
-
Recent Recovery of the Siberian High Intensity
- 2011
-
In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116
-
Journal article (peer-reviewed)abstract
- This study highlights the fast recovery of the wintertime Siberian High intensity (SHI) over the last two decades. The SHI showed a marked weakening trend from the 1970s to 1980s, leading to unprecedented low SHI in the early 1990s according to most observational data sets. This salient declining SHI trend, however, was sharply replaced by a fast recovery over the last two decades. Since the declining SHI trend has been considered as one of the plausible consequences of climate warming, the recent SHI recovery seemingly contradicts the continuous progression of climate warming in the Northern Hemisphere. We suggest that alleviated surface warming and decreased atmospheric stability in the central Siberia region, associated with an increase in Eurasian snow cover, in the recent two decades contributed to this rather unexpected SHI recovery. The prominent SHI change, however, is not reproduced by general circulation model (GCM) simulations used in the IPCC AR4. The GCMs indicate the steady weakening of the SHI for the entire 21st century, which is found to be associated with a decreasing Eurasian snow cover in the simulations. An improvement in predicting the future climate change in regional scale is desirable.
|
|
| 12. |
- Cho, Soohyun, et al.
(author)
-
Observation of Dresselhaus type spin splitting of zinc blende structure semiconductors by circular dichroic photoemission study
- 2021
-
In: Current Applied Physics. - : Elsevier BV. - 1567-1739. ; 30, s. 96-101
-
Journal article (peer-reviewed)abstract
- Material family of zinc blende structure semiconductors (ZBSSs) is important for novel technique such as spintronics. A study of the ZBSS spin-splitting structure in momentum space is essential when seeking to understand the exotic properties of the material. The Dresselhaus field predominates in the bulk, but the Rashba field plays important roles in states near the surface. Here, we used circular dichroism in angle-resolved photoemission spectroscopy (CD-ARPES) to explore the spin-splitting structure of bulk ZBSS in momentum space. The observed structure was well-explained by a Dresselhaus field attributable to the lack of inversion symmetry in ZBSS crystals. We show that CD-ARPES usefully reveals spin-splitting in momentum space. CD-ARPES combined with hard x-ray incident-beam would be useful to investigate the spin-splitting structures of the interface states in the ZBSS heterostructure.
|
|
| 13. |
- Choi, Joong Il Jake, et al.
(author)
-
Atomic-scale view of stability and degradation of single-crystal MAPbBr(3) surfaces
- 2019
-
In: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 7:36, s. 20760-20766
-
Journal article (peer-reviewed)abstract
- While organic-inorganic hybrid perovskite solar cells are emerging as promising candidates for next-generation solar cells with fascinating power conversion efficiency, the instability of perovskites remains a significant bottleneck for their commercialization. An atomic scale understanding of the degradation of hybrid perovskites, however, is only in its beginning stages because of the difficulty in preparing well-defined surface conditions for characterization. Using atomic force microscopy at ultra-high vacuum and room temperature, we report the first direct observation of the degradation process of a cleaved methylammonium lead bromide, MAPbBr(3) (MA: CH3NH3+), single crystal. Upon in situ cleavage, atomic force microscopy images show large flat terraces with monolayer height steps, which correspond to the surface of cubic MAPbBr(3) with methylammonium ligand termination. While this surface can be prepared via the cleavage process and is energetically stable, we observe that after several weeks under dark and vacuum conditions it degrades and produces clusters surrounded by pits. Guided by density functional theory calculations, we propose a degradation pathway that initiates even at low humidity levels and leads to the formation of surface PbBr2 species. We finally identify the electronic structure of the MA-bromine-terminated flat surface and find that it is correlated with a strong field-induced degradation of the MAPbBr(3) only at positive sample bias voltages.
|
|
| 14. |
|
|
| 15. |
- JEONG, SJ, et al.
(author)
-
Potential impact of vegetation feedback on European heat waves in a 2 x CO 2 climate: Vegetation impact on European heat waves
- 2010
-
In: Climatic Change. - : Springer Science and Business Media LLC. - 0165-0009 .- 1573-1480. ; 99:3-4, s. 625-635
-
Journal article (peer-reviewed)abstract
- Inclusion of the effects of vegetation feedback in a global climate change simulation suggests that the vegetation–climate feedback works to alleviate partially the summer surface warming and the associated heat waves over Europe induced by the increase in atmospheric CO2 concentrations. The projected warming of 4°C over most of Europe with static vegetation has been reduced by 1°C as the dynamic vegetation feedback effects are included.. Examination of the simulated surface energy fluxes suggests that additional greening in the presence of vegetation feedback effects enhances evapotranspiration and precipitation, thereby limiting the warming, particularly in the daily maximum temperature. The greening also tends to reduce the frequency and duration of heat waves. Results in this study strongly suggest that the inclusion of vegetation feedback within climate models is a crucial factor for improving the projection of warm season temperatures and heat waves over Europe
|
|
| 16. |
- Jung, Minyong, et al.
(author)
-
The AGORA High-resolution Galaxy Simulations Comparison Project. V. Satellite Galaxy Populations in a Cosmological Zoom-in Simulation of a Milky Way-Mass Halo
- 2024
-
In: Astrophysical Journal. - 0004-637X. ; 964:2
-
Journal article (peer-reviewed)abstract
- We analyze and compare the satellite halo populations at z ∼ 2 in the high-resolution cosmological zoom-in simulations of a 1012 M ⊙ target halo (z = 0 mass) carried out on eight widely used astrophysical simulation codes (Art-I, Enzo, Ramses, Changa, Gadget-3, Gear, Arepo-t, and Gizmo) for the AGORA High-resolution Galaxy Simulations Comparison Project. We use slightly different redshift epochs near z = 2 for each code (hereafter “z ∼ 2”) at which the eight simulations are in the same stage in the target halo’s merger history. After identifying the matched pairs of halos between the CosmoRun simulations and the DMO simulations, we discover that each CosmoRun halo tends to be less massive than its DMO counterpart. When we consider only the halos containing stellar particles at z ∼ 2, the number of satellite galaxies is significantly fewer than that of dark matter halos in all participating AGORA simulations and is comparable to the number of present-day satellites near the Milky Way or M31. The so-called “missing satellite problem” is fully resolved across all participating codes simply by implementing the common baryonic physics adopted in AGORA and the stellar feedback prescription commonly used in each code, with sufficient numerical resolution (≲100 proper pc at z = 2). We also compare other properties such as the stellar mass-halo mass relation and the mass-metallicity relation. Our work highlights the value of comparison studies such as AGORA, where outstanding problems in galaxy formation theory are studied simultaneously on multiple numerical platforms.
|
|
| 17. |
- Kim, B-M., et al.
(author)
-
Investigation of Stratospheric Precursor for the Cold Surge Event using Potential Vorticity Inversion Technique
- 2009
-
In: Asia-Pacific Journal of Atmospheric Sciences. - 1976-7633. ; 45:4, s. 513-522
-
Journal article (peer-reviewed)abstract
- The downward influence of stratospheric potential vorticity (PV) on the cold surge occurrence over East Asia was examined. Strong negative PV anomalies in the upper stratosphere and the rising of geopotential height in the upper troposphere about one week ahead of the cold surge occurrence were suggested as precursory perturbations triggering the development of the cold surge, which is dynamically validated by the piecewise potential vorticity inversion technique. When the inversion is applied to the stratospheric PV anomalies, geopotential and temperature anomalies balanced to the stratospheric PV were remarkably well reproduced in both amplitude and penetrating depth as in the observations. Although the PV anomalies are mostly confined to the stratosphere, our results confirm that its downward influences are sufficiently strong such that associated tropospheric anomalies with the stratospheric PV are capable of triggering the cold surge occurrence within the given mechanism.
|
|
| 18. |
|
|
| 19. |
- Kim, Hwi-Min, et al.
(author)
-
Monolithic integration of self-aligned nanoisland laser with shifted-air-hole waveguide
- 2018
-
In: Optics Express. - : OPTICAL SOC AMER. - 1094-4087. ; 26:10, s. 12569-12578
-
Journal article (peer-reviewed)abstract
- We report a novel scheme for monolithic integration of a nanoisland laser with a shifted-air-hole waveguide by employing selective etching techniques. An active L3 laser cavity and passive shifted-air-hole waveguide are simultaneously formed through a single fabrication step. In the shifted-air-hole waveguide, the air-hole position is adjusted to be compatible with selective etching. The spectral overlap between the L3 laser resonance and guided mode is achieved by introducing small air holes at the nodes of the shifted-air-hole waveguide. Experiments show that >60% of the light is coupled from the nanoisland laser to the end of the 12-mu m-long waveguide.
|
|
| 20. |
|
|
| 21. |
- Kwon, Kiwoong, et al.
(author)
-
Traffic-aware stateless multipath routing for fault-tolerance in IEEE 802.15.4 wireless mesh networks
- 2018
-
In: Wireless networks. - : Springer. - 1022-0038 .- 1572-8196. ; 24:5, s. 1755-1774
-
Journal article (peer-reviewed)abstract
- Single-path routing is widely used in wireless networks due to low resource consumption. However, it is vulnerable to link failure because such a failure may adversely affect an entire path. To overcome this, multipath routing has been proposed providing fault-tolerance. In this paper, we propose a novel multipath routing protocol called traffic-aware stateless multipath routing (TSMR) based on an overlaid tree topology comprising two topologies, namely, bounded degree tree (BDT) and root-oriented directional tree (RODT). BDT is strong on reducing routing overhead, and RODT is resilient against lossy links. By synergistically overlaying them, TSMR dynamically selects the local optimal path according to the given traffic flow and the failure on the primary path. In particular, TSMR enables stateless and low overhead routing despite multipath routing by keeping only one-hop neighbors to maintain multiple paths. To evaluate TSMR, we conducted simulations with a shadowing model reflecting lossy links, and compared with single and multipath routing protocols, such as ZTR, STR, AODV, and RPL. The simulation results show that the overall performance of TSMR surpasses that of others for packet delivery ratio, end-to-end delay, control overhead, memory consumption, and power consumption regardless of network size, number of sessions, and traffic flow.
|
|
| 22. |
- Lee, Hyun-Seob, et al.
(author)
-
Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function, and Cell Survival
- 2010
-
In: Stem Cells. - : Oxford University Press (OUP). - 1549-4918 .- 1066-5099. ; 28:3, s. 501-512
-
Journal article (peer-reviewed)abstract
- Effective dopamine (DA) neuron differentiation from neural precursor cells (NPCs) is prerequisite for precursor/stem cell-based therapy of Parkinson's disease (PD). Nurr1, an orphan nuclear receptor, has been reported as a transcription factor that can drive DA neuron differentiation from non-dopaminergic NPCs in vitro. However, Nurr1 alone neither induces full neuronal maturation nor expression of proteins found specifically in midbrain DA neurons. In addition, Nurr1 expression is inefficient in inducing DA phenotype expression in NPCs derived from certain species such as mouse and human. We show here that Foxa2, a forkhead transcription factor whose role in midbrain DA neuron development was recently revealed, synergistically cooperates with Nurr1 to induce DA phenotype acquisition, midbrain-specific gene expression, and neuronal maturation. Thus, the combinatorial expression of Nurr1 and Foxa2 in NPCs efficiently yielded fully differentiated nigral (A9)-type midbrain neurons with clearly detectable DA neuronal activities. The effects of Foxa2 in DA neuron generation were observed regardless of the brain regions or species from which NPCs were derived. Furthermore, DA neurons generated by ectopic Foxa2 expression were more resistant to toxins. Importantly, Foxa2 expression resulted in a rapid cell cycle exit and reduced cell proliferation. Consistently, transplantation of NPCs transduced with Nurr1 and Foxa2 generated grafts enriched with midbrain-type DA neurons but reduced number of proliferating cells, and significantly reversed motor deficits in a rat PD model. Our findings can be applied to ongoing attempts to develop an efficient and safe precursor/stem cell-based therapy for PD. STEM CELLS 2010; 28: 501-512
|
|
| 23. |
- Lee, Jae-Hoon, et al.
(author)
-
Comparative study on analysis methods for added resistance of four ships in head and oblique waves
- 2021
-
In: Ocean Engineering. - : Elsevier Ltd. - 0029-8018 .- 1873-5258. ; 236
-
Journal article (peer-reviewed)abstract
- This paper presents a comparative study of wave-induced motion responses and the added resistance of a ship. Four representative types of ships are adopted as test models: LNG carrier, tanker, containership, and bulk carrier. Two experimental techniques—captive and free-running model tests—are conducted under regular head and oblique wave conditions to create benchmark data. Several numerical computation methods (asymptotic formula, 2D strip theory, 3D panel method, and CFD) are applied to perform the seakeeping analysis. The comparison results indicate that the accuracy and reliability of each analysis technique are validated, and its characteristics and limitations are investigated with respect to the physical aspects of the added resistance caused by a wave. The analysis results are compared based on how steady flow-induced coupling effects are considered. Further, the sensitivities of seakeeping quantities with respect to wave steepness were examined based on the results of linear and fully nonlinear computations. The overall tendency of the added resistance in accordance with the incident direction of a wave is discussed. © 2021 The Author(s)
|
|
| 24. |
- Lee, Seung Won, et al.
(author)
-
Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study
- 2022
-
In: British Journal of Sports Medicine. - : BMJ PUBLISHING GROUP. - 0306-3674 .- 1473-0480. ; 56:16, s. 901-912
-
Journal article (peer-reviewed)abstract
- Purpose To determine the potential associations between physical activity and risk of SARS-CoV-2 infection, severe illness from COVID-19 and COVID-19 related death using a nationwide cohort from South Korea. Methods Data regarding 212 768 Korean adults (age >= 20 years), who tested for SARS-CoV-2, from 1 January 2020 to 30 May 2020, were obtained from the National Health Insurance Service of South Korea and further linked with the national general health examination from 1 January 2018 to 31 December 2019 to assess physical activity levels. SARS-CoV-2 positivity, severe COVID-19 illness and COVID-19 related death were the main outcomes. The observation period was between 1 January 2020 and 31 July 2020. Results Out of 76 395 participants who completed the general health examination and were tested for SARS-CoV-2, 2295 (3.0%) were positive for SARS-CoV-2, 446 (0.58%) had severe illness from COVID-19 and 45 (0.059%) died from COVID-19. Adults who engaged in both aerobic and muscle strengthening activities according to the 2018 physical activity guidelines had a lower risk of SARS-CoV-2 infection (2.6% vs 3.1%; adjusted relative risk (aRR), 0.85; 95% CI 0.72 to 0.96), severe COVID-19 illness (0.35% vs 0.66%; aRR 0.42; 95% CI 0.19 to 0.91) and COVID-19 related death (0.02% vs 0.08%; aRR 0.24; 95% CI 0.05 to 0.99) than those who engaged in insufficient aerobic and muscle strengthening activities. Furthermore, the recommended range of metabolic equivalent task (MET; 500-1000 MET min/week) was associated with the maximum beneficial effect size for reduced risk of SARS-CoV-2 infection (aRR 0.78; 95% CI 0.66 to 0.92), severe COVID-19 illness (aRR 0.62; 95% CI 0.43 to 0.90) and COVID-19 related death (aRR 0.17; 95% CI 0.07 to 0.98). Similar patterns of association were observed in different sensitivity analyses. Conclusion Adults who engaged in the recommended levels of physical activity were associated with a decreased likelihood of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related death. Our findings suggest that engaging in physical activity has substantial public health value and demonstrates potential benefits to combat COVID-19.
|
|
| 25. |
- Roca-Fàbrega, Santi, et al.
(author)
-
The AGORA High-resolution Galaxy Simulations Comparison Project. IV. Halo and Galaxy Mass Assembly in a Cosmological Zoom-in Simulation at z ≤ 2
- 2024
-
In: Astrophysical Journal. - 0004-637X. ; 968:2
-
Journal article (peer-reviewed)abstract
- In this fourth paper from the AGORA Collaboration, we study the evolution down to redshift z = 2 and below of a set of cosmological zoom-in simulations of a Milky Way mass galaxy by eight of the leading hydrodynamic simulation codes. We also compare this CosmoRun suite of simulations with dark matter-only simulations by the same eight codes. We analyze general properties of the halo and galaxy at z = 4 and 3, and before the last major merger, focusing on the formation of well-defined rotationally supported disks, the mass-metallicity relation, the specific star formation rate, the gas metallicity gradients, and the nonaxisymmetric structures in the stellar disks. Codes generally converge well to the stellar-to-halo mass ratios predicted by semianalytic models at z ∼ 2. We see that almost all the hydro codes develop rotationally supported structures at low redshifts. Most agree within 0.5 dex with the observed mass-metallicity relation at high and intermediate redshifts, and reproduce the gas metallicity gradients obtained from analytical models and low-redshift observations. We confirm that the intercode differences in the halo assembly history reported in the first paper of the collaboration also exist in CosmoRun, making the code-to-code comparison more difficult. We show that such differences are mainly due to variations in code-dependent parameters that control the time stepping strategy of the gravity solver. We find that variations in the early stellar feedback can also result in differences in the timing of the low-redshift mergers. All the simulation data down to z = 2 and the auxiliary data will be made publicly available.
|
|
| 26. |
- Strawn, Clayton, et al.
(author)
-
The AGORA High-resolution Galaxy Simulations Comparison Project. VI. Similarities and Differences in the Circumgalactic Medium
- 2024
-
In: Astrophysical Journal. - 0004-637X. ; 962:1
-
Journal article (peer-reviewed)abstract
- We analyze the circumgalactic medium (CGM) for eight commonly-used cosmological codes in the AGORA collaboration. The codes are calibrated to use identical initial conditions, cosmology, heating and cooling, and star formation thresholds, but each evolves with its own unique code architecture and stellar feedback implementation. Here, we analyze the results of these simulations in terms of the structure, composition, and phase dynamics of the CGM. We show properties such as metal distribution, ionization levels, and kinematics are effective tracers of the effects of the different code feedback and implementation methods, and as such they can be highly divergent between simulations. This is merely a fiducial set of models, against which we will in the future compare multiple feedback recipes for each code. Nevertheless, we find that the large parameter space these simulations establish can help disentangle the different variables that affect observable quantities in the CGM, e.g., showing that abundances for ions with higher ionization energy are more strongly determined by the simulation’s metallicity, while abundances for ions with lower ionization energy are more strongly determined by the gas density and temperature.
|
|
| 27. |
|
|
| 28. |
- Boya, K., et al.
(author)
-
Possible candidate for the realization of the floating phase in the S=5/2 frustrated spin-chain model : K3Fe(MoO4)2(Mo2O7 )
- 2024
-
In: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 109:15
-
Journal article (peer-reviewed)abstract
- The frustrated spin-chain (FSC) systems exhibit exotic ground states and distinct quantum phase transitions. The ?=1/2 FSC is known to exhibit the Kosterlitz-Thouless transition from a commensurate gapless phase to a fully dimerized gapped phase upon the ratio of next-nearest-neighbor to nearest-neighbor coupling (?=?2/?1) being tuned. On the other hand, the ?=5/2 FSC system is known to show transitions from a commensurate gapless phase to partially dimerized and incommensurate floating phases [Chepiga, Affleck, and Mila, Phys. Rev. B 105, 174402 (2022)]. While a large region of the floating phase has been theoretically predicted for the ?=5/2 FSC model when ?>0.43, it is yet to be explored experimentally. Here, we have investigated a compound K3Fe(MoO4)2(Mo2O7), having well-separated ?=5/2 FSCs. The electronic structure calculations show that the ?=?2/?1 is close to 0.9, being similar to another FSC compound Bi3FeMo2O12 (?≈1.1). No magnetic long-range order is found down to 0.09 K, despite the relatively sizable Curie-Weiss temperature ???=−18K. The magnetic heat capacity shows the power-law behavior, indicating that the compound exhibits gapless excitations. Based on the experimental results and the theoretical calculations employed by density functional theory, we argue that the titled system is a possible candidate for exhibiting the floating phase.
|
|
| 29. |
- Caliskan, Etem, et al.
(author)
-
Saphenous vein grafts in contemporary coronary artery bypass graft surgery
- 2020
-
In: Nature Reviews Cardiology. - : Nature Publishing Group. - 1759-5002 .- 1759-5010. ; 17:3, s. 155-169
-
Research review (peer-reviewed)abstract
- Myocardial ischaemia resulting from obstructive coronary artery disease is a major cause of morbidity and mortality in the developed world. Coronary artery bypass graft (CABG) surgery is the gold-standard treatment in many patients with complex multivessel coronary artery disease or left main disease. Despite substantial improvements in the outcome of patients undergoing CABG surgery in the past decade, graft patency remains the 'Achilles' heel' of this procedure. Whereas the use of the left internal mammary artery as a conduit is associated with the highest 10-year patency rate (>90%), saphenous vein grafts - the most commonly used conduit in CABG surgery - fail in 40-50% of treated patients by 10 years after surgery. Vein graft disease (VGD) and failure result from complex pathophysiological processes that can lead to complete occlusion of the graft, affecting long-term clinical outcomes. Optimal harvesting techniques, intraoperative preservation strategies and intraoperative patency control have important roles in the prevention of VGD. In addition, several studies published in the past decade have reported similar mid-term patency rates between vein grafts and arterial grafts when veins are used as a composite graft based on the internal mammary artery. In this Review, we present the latest evidence on the utilization of saphenous vein grafts for CABG surgery and provide an overview of the current practices for the prevention of VGD and vein graft failure.
|
|
| 30. |
|
|
| 31. |
- Cho, Hyunsoo, et al.
(author)
-
YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis
- 2019
-
In: Circulation Research. - : Lippincott Williams & Wilkins. - 0009-7330 .- 1524-4571. ; 124:2, s. 225-242
-
Journal article (peer-reviewed)abstract
- Rationale: The Hippo pathway governs cellular differentiation, morphogenesis, and homeostasis, but how it regulates these processes in lymphatic vessels is unknown. Objective: We aimed to reveal the role of the final effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), in lymphatic endothelial cell (LEC) differentiation, morphogenesis, and homeostasis. Methods and Results: During mouse embryonic development, LEC-specific depletion of Yap/Taz disturbed both plexus patterning and valve initiation with upregulated Prox1 (prospero homeobox 1). Conversely, LEC-specific YAP/TAZ hyperactivation impaired lymphatic specification and restricted lymphatic sprouting with profoundly downregulated Prox1. Notably, lymphatic YAP/TAZ depletion or hyperactivation aggravated or attenuated pathological lymphangiogenesis in mouse cornea. Mechanistically, VEGF (vascular endothelial growth factor)-C activated canonical Hippo signaling pathway in LECs. Indeed, repression of PROX1 transcription by YAP/TAZ hyperactivation was mediated by recruitment of NuRD (nucleosome remodeling and histone deacetylase) complex and endogenous binding activity of TEAD (TEA domain family members) to the PROX1 promoter. Furthermore, YAP/TAZ hyperactivation enhanced MYC signaling and inhibited CDKN1C, leading to cell cycle dysregulation and aberrant proliferation. Conclusions: We find that YAP and TAZ play promoting roles in remodeling lymphatic plexus patterning and postnatal lymphatic valve maintenance by negatively regulating Prox1 expression. We further show that YAP and TAZ act as plastic regulators of lymphatic identity and define the Hippo signaling-mediated PROX1 transcriptional programing as a novel dynamic checkpoint underlying LEC plasticity and pathophysiology.
|
|
| 32. |
- Choi, Joong Il Jake, et al.
(author)
-
Surface Termination-Dependent Nanotribological Properties of Single-Crystal MAPbBr(3) Surfaces
- 2020
-
In: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 124:2, s. 1484-1491
-
Journal article (peer-reviewed)abstract
- Atomistic characterization of surface termination and the corresponding mechanical properties of single-crystal methylammonium lead tribromide (MAPbBr(3)) are performed using combined atomic force microscopy (AFM) measurements and density functional theory (DFT) calculations. A clean MAPbBr(3) surface is obtained by in situ cleavage in ultrahigh vacuum at room temperature, and the subsequent AFM measurements of the as-cleaved MAPbBr(3) exhibit the coexistence of two different surface terrace types with step height differences corresponding to about half the thickness of a PbI6 octahedron layer. Concurrent friction force microscopy measurements show that the two surfaces result in two distinct friction values. Based on DFT calculations, we attribute the higher-friction and lower-friction surfaces to MABr-terminated flat and PbBr2-terminated vacant surface terminations, respectively. The calculated electronic band structures of the various MABr- and PbBr2-terminated surfaces show that the midgap states are absent, revealing the defect-tolerant nature of the ideal single-crystal MAPbBr(3) surfaces.
|
|
| 33. |
- De Adhikari, Amrita, et al.
(author)
-
Polyaniline-Stabilized Intertwined Network-like Ferrocene/Graphene Nanoarchitecture for Supercapacitor Application
- 2017
-
In: Chemistry - An Asian Journal. - : WILEY-V C H VERLAG GMBH. - 1861-4728 .- 1861-471X. ; 12:8, s. 900-909
-
Journal article (peer-reviewed)abstract
- The present work highlights the effective H-p interaction between metallocenes ( ferrocene; Fc) and graphene and their stabilization in the presence of polyaniline ( PANI) through pi-pi interactions. The PANI-stabilized Fc@ graphene nanocomposite ( FcGA) resembled an intertwined network-like morphology with high surface area and porosity, which could make it a potential candidate for energy-storage applications. The relative interactions between the components were assessed through theoretical ( DFT) calculations. The specific capacitance calculated from galvanostatic charging/discharging indicated that the PANI-stabilized ter-nary nanocomposite exhibited a maximum specific capacitance of 960 Fg(-) at an energy density of 85 WhKg(-1) and a current density of 1 Ag-. Furthermore, electrochemical impedance spectroscopy (EIS) analysis confirmed the low internal resistance of the as-prepared nanocomposites, which showed improved charge-transfer properties of graphene after incorporation of Fc and stabilization with PANI. Additionally, all electrodes were found to be stable up to 5000 cycles with a specific capacitance retention of 86%, thus demonstrating the good reversibility and durability of the electrode material.
|
|
| 34. |
- De Groot, Natasja M.S., et al.
(author)
-
Critical appraisal of technologies to assess electrical activity during atrial fibrillation : a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology
- 2022
-
In: Europace. - : Oxford University Press (OUP). - 1099-5129. ; 24:2, s. 313-330
-
Research review (peer-reviewed)abstract
- We aim to provide a critical appraisal of basic concepts underlying signal recording and processing technologies applied for (i) atrial fibrillation (AF) mapping to unravel AF mechanisms and/or identifying target sites for AF therapy and (ii) AF detection, to optimize usage of technologies, stimulate research aimed at closing knowledge gaps, and developing ideal AF recording and processing technologies. Recording and processing techniques for assessment of electrical activity during AF essential for diagnosis and guiding ablative therapy including body surface electrocardiograms (ECG) and endo- or epicardial electrograms (EGM) are evaluated. Discussion of (i) differences in uni-, bi-, and multi-polar (omnipolar/Laplacian) recording modes, (ii) impact of recording technologies on EGM morphology, (iii) global or local mapping using various types of EGM involving signal processing techniques including isochronal-, voltage- fractionation-, dipole density-, and rotor mapping, enabling derivation of parameters like atrial rate, entropy, conduction velocity/direction, (iv) value of epicardial and optical mapping, (v) AF detection by cardiac implantable electronic devices containing various detection algorithms applicable to stored EGMs, (vi) contribution of machine learning (ML) to further improvement of signals processing technologies. Recording and processing of EGM (or ECG) are the cornerstones of (body surface) mapping of AF. Currently available AF recording and processing technologies are mainly restricted to specific applications or have technological limitations. Improvements in AF mapping by obtaining highest fidelity source signals (e.g. catheter-electrode combinations) for signal processing (e.g. filtering, digitization, and noise elimination) is of utmost importance. Novel acquisition instruments (multi-polar catheters combined with improved physical modelling and ML techniques) will enable enhanced and automated interpretation of EGM recordings in the near future.
|
|
| 35. |
- Han, Sang-wook, et al.
(author)
-
A Distributed Power Allocation Scheme for Sum-Rate Maximization on Cognitive GMACs
- 2013
-
In: IEEE Transactions on Communications. - 0090-6778 .- 1558-0857. ; 61:1, s. 248-256
-
Journal article (peer-reviewed)abstract
- This paper considers a distributed power allocation scheme for sum-rate-maximization under cognitive Gaussian multiple access channels (GMACs), where primary users and secondary users may communicate under mutual interference with the Gaussian noise. Formulating the problem as a standard nonconvex quadratically constrained quadratic problem (QCQP) provides a simple distributed method to find a solution using iterative Jacobian method instead of using centralized schemes. A totally asynchronous distributed power allocation for sum-rate maximization on cognitive GMACs is suggested. Simulation results show that this distributed algorithm for power allocation converges to a fixed point and the solution achieves almost the same performance as the exhaustive search.
|
|
| 36. |
- HO, CH, et al.
(author)
-
Influence of stratospheric quasi-biennial oscillation on tropical cyclone tracks in the western North Pacific
- 2009
-
In: GEOPHYSICAL RESEARCH LETTERS. - 0094-8276. ; 36
-
Journal article (peer-reviewed)abstract
- The possible influence of the stratospheric quasi-biennial oscillation (QBO) on tropical cyclone (TC) passages in the western North Pacific (WNP) is examined using TC data recorded by the Tokyo Typhoon Center and the QBO index derived from reanalysis data. The influence is observed to be significant. The number of TCs approaching the East China Sea is large during the westerly phase of the QBO; however, during the easterly phase, the number of TCs approaching the eastern offshore of Japan is large. This difference in the TC tracks is found to be related to the background flow change associated with the QBO. However, the total number of TC events over the WNP and the sum of the number of TCs approaching the aforementioned two regions appear to be unrelated to the QBO phases. Citation: Ho, C.-H., H.- S. Kim, J.- H. Jeong, and S.-W. Son (2009), Influence of stratospheric quasi-biennial oscillation on tropical cyclone tracks in the western North Pacific, Geophys. Res. Lett., 36, L06702, doi:10.1029/2009GL037163.
|
|
| 37. |
- Hosseini, Seyed Mehdi, et al.
(author)
-
Lipase-immobilized chitosan-crosslinked magnetic nanoparticle as a biocatalyst for ring opening esterification of itaconic anhydride
- 2019
-
In: Biochemical Engineering Journal. - : Elsevier BV. - 1369-703X. ; 143, s. 141-150
-
Journal article (peer-reviewed)abstract
- Nano-magnetic biocatalyst particles, lipase-immobilized chitosan-crosslinked magnetic nanoparticles (LCMNs) were prepared by a new approach integrated from magnetic nanoparticle preparation, in situ thin layer coating and crosslinking of chitosan, and enzyme immobilization method. Thin layer coating of magnetic (Fe3O4) by crosslinked chitosan nanoparticles were prepared by reacting FeCl3.6H2O and sodium acetate in ethylene glycol, followed by suspension cross-linking using citric acid on the hydroxyl and amine group of chitosan at neutral pH. The resulting nanoparticles were used to immobilize the lipase from Candida antarctica Lipase B by linking using glutaraldehyde. The particles in each step were characterized by Fourier transform infrared spectrometry (FT-IR), vibrating-sample magnetometer measurements (VSM), and transmission electron microscopy (TEM). The magnetic biocatalyst, LCMN was found to have high storage stability and reusability due to the tightly crosslinked structure of chitosan and covalent bond immobilization. LCMNs were used for the oligomerization of itaconic anhydride by ring opening esterification, and the results were compared with those from free lipase and commercial immobilized lipase. The molecular mass of the products obtained with the biocatalysts showed similar Mn profiles with 308–381. This process represents a green approach for the preparation of both biobased magnetic biocatalysts and functional oligo-esters, and can be applied for both the immobilization of other enzymes and the utilization of photo-curable functional esters as biobased functional materials.
|
|
| 38. |
- Huang, Tzu-Hao, et al.
(author)
-
Separating Si phases from diagenetically-modified sediments through sequential leaching.
- 2023
-
In: Chemical Geology. - 0009-2541 .- 1872-6836.
-
Journal article (peer-reviewed)abstract
- Silicon (Si) phases such as biogenic silica, lithogenic silicate and authigenic silica/silicate in marine sediments provide valuable information about past Si cycling. Wet-chemical sequential leaching methods are often applied to extract different Si phases from marine sediments to study Si diagenetic processes in shallow subsurface. The potential of this method to separate Si phases from deeply-buried and diagenetically-modified sediments has not been systematically examined. We applied a sequential leaching protocol to drill core sediments retrieved from the Ulleung Basin, East/Japan Sea. We performed geochemical (elemental abundance and stable Si isotopes, δ30Si) and microscopic (X-ray diffraction and scanning electron microscope) analyses to monitor leaching efficiency in separating different Si phases. We show that, prior to alkaline leaching, applying weak acid is able to remove metal oxide and/or clay-like phases. The following Na2CO3 leaching, based on a commonly-adopted protocol, is able to dissolve some but not all diatoms. The results of elemental contents and δ30Si values of leachates suggest that, in diagenetically-modified sediments, either a longer digesting time or a harsher alkaline leaching is needed to dissolve all diatoms. This is attributed to increased resistance of diatoms to Na2CO3 leaching as a result of reduced surface area and/or improved SiO2 tetrahedron ordering during diagenetic processes over time and burial depths. Lithogenic silicate minerals can be dissolved by NaOH and potentially separated from diatoms if the latter is completely removed in the preceding leaching steps. Even if a trace amount of diatom is left undissolved in the NaOH leaching, it is still possible to separate the two through a mass balance calculation given the knowledge of composition for the two end-members. We conclude that a successful separation of Si phases in diagenetically modified sediments relies on the knowledge of elemental abundance and even δ30Si values of the leachates, as well as information such as species of Si-skeleton organisms, contents and maturation degree of biogenic silica.
|
|
| 39. |
- Jang, Jeong Keun, et al.
(author)
-
Area-efficient scheduling scheme based FFT processor for various OFDM systems
- 2018
-
In: 2018 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS (APCCAS 2018). - : IEEE. - 9781538682401 ; , s. 338-341
-
Conference paper (other academic/artistic)abstract
- This paper presents an area-efficient fast Fouriertransform (FFT) processor for orthogonal frequency-division multiplexing systems based on multi-path delay commutator architecture. This paper proposes a data scheduling scheme to reduce the number of complex constant multipliers. The proposed mixed-radix multi-path delay commutator FFT processor can support 128-, 256-, and 512-point FFT sizes. The proposed processor was synthesized using the Samsung 65-nm CMOS standard cell library. The proposed processor with eight parallel data paths can achieve a high throughput rate of up to 2.64 GSample/s at 330 MHz.
|
|
| 40. |
- Jeong, Jee-Hoon, 1976, et al.
(author)
-
Greening in the circumpolar high-latitude may amplify warming in the growing season
- 2012
-
In: Climate Dynamics. - : Springer Science and Business Media LLC. - 0930-7575 .- 1432-0894. ; 38:7-8, s. 1421-1431
-
Journal article (peer-reviewed)abstract
- We present a study that suggests greening in the circumpolar high-latitude regions amplifies surface warming in the growing season (May–September) under enhanced greenhouse conditions. The investigation used a series of climate simulations with the Community Atmospheric Model version 3—which incorporates a coupled, dynamic global vegetation model—with and without vegetation feedback, under both present and doubled CO2 concentrations. Results indicate that climate warming and associated changes promote circumpolar greening with northward expansion and enhanced greenness of both the Arctic tundra and boreal forest regions. This leads to additional surface warming in the high-latitudes in the growing season, primarily through more absorption of incoming solar radiation. The resulting surface and tropospheric warming in the high-latitude and Arctic regions weakens prevailing tropospheric westerlies over 45–70N, leading to the formation of anticyclonic pressure anomalies in the Arctic regions. These pressure anomalies resemble the anomalous circulation pattern during the negative phase of winter Arctic Oscillation. It is suggested that these circulation anomalies reinforce the high-latitude and Arctic warming in the growing season.
|
|
| 41. |
- Jeong, Jee-Hoon, 1976, et al.
(author)
-
Intensified Arctic warming under greenhouse warming by vegetation–atmosphere–sea ice interaction
- 2014
-
In: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 9
-
Journal article (peer-reviewed)abstract
- Observations and modeling studies indicate that enhanced vegetation activities over high latitudes under an elevated CO2 concentration accelerate surface warming by reducing the surface albedo. In this study, we suggest that vegetation-atmosphere-sea ice interactions over high latitudes can induce an additional amplification of Arctic warming. Our hypothesis is tested by a series of coupled vegetation-climate model simulations under 2xCO2 environments. The increased vegetation activities over high latitudes under a 2xCO2 condition induce additional surface warming and turbulent heat fluxes to the atmosphere, which are transported to the Arctic through the atmosphere. This causes additional sea-ice melting and upper-ocean warming during the warm season. As a consequence, the Arctic and high-latitude warming is greatly amplified in the following winter and spring, which further promotes vegetation activities the following year. We conclude that the vegetation-atmosphere-sea ice interaction gives rise to additional positive feedback of the Arctic amplification.
|
|
| 42. |
|
|
| 43. |
- JEONG, SJ, et al.
(author)
-
Reduction of spring warming over East Asia associated with vegetation feedback
- 2009
-
In: GEOPHYSICAL RESEARCH LETTERS. - 0094-8276. ; 36
-
Journal article (peer-reviewed)abstract
- Over East Asia, surface air temperature displays a significant increasing trend particularly in early months of the year for the period of 1982-2000. Warming per decade is strongest in late winter, 1.5 degrees C in February and 1.1 degrees C in March, but is significantly reduced in spring, 0.4 degrees C in April and 0.1 degrees C in May. During the analysis period, the reduced temperature increase from late winter to spring is found to be in contrast with the increased vegetation greenness derived from the satellite-measured leaf area index over the domain. We examined this inverse relationship using two climate model experiments-coupled with and without a dynamic vegetation model. In both experiments, strong warming in winter is relatively well reproduced, but weak warming in spring is observed only in the coupled experiment. Analysis of the surface energy budget indicates that weaker spring warming results from an evaporative cooling effect due to the increased vegetation greenness. Over East Asia, the vegetation-evaporation feedback, therefore, may produce seasonal asymmetry in the warming trend. Citation: Jeong, S.-J., C.-H. Ho, K.-Y. Kim, and J.-H. Jeong (2009), Reduction of spring warming over East Asia associated with vegetation feedback, Geophys. Res. Lett., 36, L18705, doi: 10.1029/2009GL039114.
|
|
| 44. |
- Kang, Jinho, et al.
(author)
-
Application of a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with orthogonal projections to latent structure-discriminant analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines
- 2008
-
In: Journal of Agricultural and Food Chemistry. - Washington : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 56:24, s. 11589-11595
-
Journal article (peer-reviewed)abstract
- Correct identification of the origins of herbal medical products is becoming increasingly important in tandem with the growing interest in alternative medicine. However, visual inspection of raw material is still the most widely used method, and newer scientific approaches are needed. To develop a more objective and efficient tool for discriminating herbal origins, particularly Korean and Chinese, we employed a nuclear magnetic resonance (NMR)-based metabolomics approach combined with an orthogonal projections to latent structure-discriminant analysis (OPLS-DA) multivariate analysis. We first analyzed the constituent metabolites of Scutellaria baicalensis through NMR studies. Subsequent holistic data analysis with OPLS-DA yielded a statistical model that could cleanly discriminate between the sample groups even in the presence of large structured noise. An analysis of the statistical total correlation spectroscopy (STOCSY) spectrum identified citric acid and arginine as the key discriminating metabolites for Korean and Chinese samples. As a validation of the discrimination model, we performed blind prediction tests of sample origins using an external test set. Our model correctly predicted the origins of all of the 11 test samples, demonstrating its robustness. We tested the wider applicability of the developed method with three additional herbal medicines from Korea and China and obtained very high prediction accuracy. The solid discriminatory power and statistical validity of our method suggest its general applicability for determining the origins of herbal medicines.
|
|
| 45. |
|
|
| 46. |
|
|
| 47. |
- Katritsis, Demosthenes G, et al.
(author)
-
Executive Summary : European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias
- 2016
-
In: Arrhythmia & electrophysiology review. - 2050-3369. ; 5:3, s. 210-224
-
Journal article (peer-reviewed)abstract
- This paper is an executive summary of the full European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, published in Europace. It summarises developments in the field and provides recommendations for patient management, with particular emphasis on new advances since the previous European Society of Cardiology guidelines. The EHRA consensus document is available to read in full at http://europace.oxfordjournals.org.
|
|
| 48. |
|
|
| 49. |
- Kim, Hyunsu, et al.
(author)
-
Photo-Programmed Deformations in Rigid Liquid Crystalline Polymers Triggered by Body Temperature
- 2022
-
In: Small. - : Wiley. - 1613-6829 .- 1613-6810. ; , s. 2203772-
-
Journal article (peer-reviewed)abstract
- Abstract Deformations triggered by body heat are desirable in the context of shape-morphing applications because, under the majority of circumstances, the human body maintains a higher temperature than that of its surroundings. However, at present, this bioenergy-triggered action is primarily limited to soft polymeric networks. Thus, herein, the programming of body temperature-triggered deformations into rigid azobenzene-containing liquid crystalline polymers (azo-LCPs) with a glass-transition temperature of 100 °C is demonstrated. To achieve this, a mechano-assisted photo-programming strategy is used to create a metastable state with room-temperature stable residual stress, which is induced by the isomerization of azobenzene. The programmed rigid azo-LCP can undergo large-amplitude body temperature-triggered shape changes within minutes and can be regenerated without any performance degradation. By changing the programming photomasks and irradiation conditions employed, various 2D to 3D shape-morphing architectures, including folded clips, inch-worm structures, spiral structures, and snap-through motions are achieved. When programmed with polarized light, the proposed strategy results in domain-selective activation, generating designed characteristics in multi-domain azo-LCPs. The reported strategy is therefore expected to broaden the applications of azo-LCPs in the fields of biomedical and flexible microelectronic devices.
|
|
| 50. |
- Kim, HoUng, et al.
(author)
-
The Future of Biosimilars : Maximizing Benefits Across Immune-Mediated Inflammatory Diseases
- 2020
-
In: Drugs. - : Adis International. - 0012-6667 .- 1179-1950. ; 80:2, s. 99-113
-
Journal article (peer-reviewed)abstract
- Biologics have transformed the treatment of immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Biosimilars-biologic medicines with no clinically meaningful differences in safety or efficacy from licensed originators-can stimulate market competition and have the potential to expand patient access to biologics within the parameters of treatment recommendations. However, maximizing the benefits of biosimilars requires cooperation between multiple stakeholders. Regulators and developers should collaborate to ensure biosimilars reach patients rapidly without compromising stringent quality, safety, or efficacy standards. Pharmacoeconomic evaluations and payer policies should be updated following biosimilar market entry, minimizing the risk of imposing nonmedical barriers to biologic treatment. In RA, disparities between treatment guidelines and national reimbursement criteria could be addressed to ensure more uniform patient access to biologics and enable rheumatologists to effectively implement treat-to-target strategies. In IBD, the cost-effectiveness of biologic treatment earlier in the disease course is likely to improve when biosimilars are incorporated into pharmacoeconomic analyses. Patient understanding of biosimilars is crucial for treatment success and avoiding nocebo effects. Full understanding of biosimilars by physicians and carefully considered communication strategies can help support patients initiating or switching to biosimilars. Developers must operate efficiently to be sustainable, without undermining product quality, the reliability of the supply chain, or pharmacovigilance. Developers should also facilitate information sharing to meet the needs of other stakeholders. Such collaboration will help to ensure a sustainable future for both the biosimilar market and healthcare systems, supporting the availability of effective treatments for patients.
|
|
