SwePub - search: WFRF:(Knutsson Anders)

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1.	Hermansson, Ulric, et al. (author) Screening for high-risk and elevated alcohol consumption in day and shift workers by use of the AUDIT and CDT 2003 In: Occupational Medicine. - : Oxford University Press (OUP). - 0962-7480 .- 1471-8405. ; 53:8, s. 518-526 Journal article (peer-reviewed)abstract The present findings on employees who attended for regular health examinations suggest that shift workers did not show a higher level of risky alcohol consumption than day workers, according to the results with the AUDIT, CDT and GGT. On the contrary, the two-shift workers appeared to drink significantly less.
2.	Ahlin, Anders, et al. (author) GMMS 3.0 : Handbok för utformning av användargränssnitt 1997 Book (other academic/artistic)
3.	Bernander, Stig, et al. (author) Downhill progressive landslides in long natural slopes: triggering agents and landslide phases modeled with a finite difference method 2016 In: Canadian geotechnical journal (Print). - : Canadian Science Publishing. - 0008-3674 .- 1208-6010. ; 53:10, s. 1565-1582 Journal article (peer-reviewed)abstract A large landslide in Tuve (Gothenburg, Sweden 1977) initiated the development of a model for slope stability analysis taking the deformation-softening of soft sensitive clays into consideration. The model studies triggering agents and five phases in progressive slope failure are identified: (1) in-situ, (2) disturbance, (3) unstable ‘dynamic’, (4) transitory (or permanent) equilibrium, and (5) ‘global’ failure. The clay resistance in these phases may differ widely; mostly due to different rates of loading. Two time dependent failure criteria are defined: (i) the triggering load condition in the disturbance Phase (2), and (ii) the transitory equilibrium in Phase (4), indicating whether minor downhill displacements or a veritable landslide catastrophe will occur. The analysis explains why downhill landslides tend to spread over vast areas of almost horizontal ground further down-slope. The model has been applied to landslides in Scandinavia and Canada. Three case studies are briefly discussed. The model is a finite difference approach, where local downhill deformations caused by normal forces is maintained compatible with deviatory shear deformations above the potential (or the established) failure surface. Software and an easy-to-use spreadsheet are introduced as well as recent developments. See also Video Abstract.
4.	Eklund, Anders, et al. (author) A Brain Computer Interface for Communication Using Real-Time fMRI 2010 In: Proceedings of the 20th International Conference on Pattern Recognition. - Los Alamitos, CA, USA : IEEE Computer Society. - 9781424475421 ; , s. 3665-3669 Conference paper (peer-reviewed)abstract We present the first step towards a brain computer interface (BCI) for communication using real-time functional magnetic resonance imaging (fMRI). The subject in the MR scanner sees a virtual keyboard and steers a cursor to select different letters that can be combined to create words. The cursor is moved to the left by activating the left hand, to the right by activating the right hand, down by activating the left toes and up by activating the right toes. To select a letter, the subject simply rests for a number of seconds. We can thus communicate with the subject in the scanner by for example showing questions that the subject can answer. Similar BCI for communication have been made with electroencephalography (EEG). The subject then focuses on a letter while different rows and columns of the virtual keyboard are flashing and the system tries to detect if the correct letter is flashing or not. In our setup we instead classify the brain activity. Our system is neither limited to a communication interface, but can be used for any interface where five degrees of freedom is necessary.
5.	Eklund, Anders, et al. (author) Balancing an Inverted Pendulum by Thinking A Real-Time fMRI Approach 2009 Conference paper (other academic/artistic)abstract We present a method for controlling a dynamical system using real-time fMRI. The objective for the subject in the MR scanner is to balance an inverse pendulum by activating the left or right hand or resting. The brain activity is classified each second by a neural network and the classification is sent to a pendulum simulator to change the force applied to the pendulum. The state of the inverse pendulum is shown to the subject in a pair of VR goggles. The subject was able to balance the inverse pendulum both with real activity and imagined activity. The developments here have a potential to aid people with communication disabilities e.g., locked in people. It might also be a tool for stroke patients to be ableto train the damaged brain area and get real-time feedback of when they do it right.
6.	Eklund, Anders, et al. (author) Using Real-Time fMRI to Control a Dynamical System 2009 In: ISMRM 17th Scientific Meeting & Exhibition. - Linköping : Linköping University Electronic Press. Conference paper (peer-reviewed)abstract We present e method for controlling a dynamical system using real-time fMRI. The objective for the subject in the MR scanner is to balance an inverse pendulum by activating the left or right hand or resting. The brain activity is clasified each second by a neural network and the classification is sent to a pendulum simulator to change the state of the pendulum. The state of the inverse pendulum is shown to the subject in a pair of VR goggles. The subject was able to balance the inverse pendulum during a 7 minute test run.
7.	Eklund, Anders, et al. (author) Using Real-Time fMRI to Control a Dynamical System by Brain Activity Classification 2010 Reports (other academic/artistic)abstract We present a method for controlling a dynamical system using real-time fMRI. The objective for the subject in the MR scanner is to balance an inverted pendulum by activating the left or right hand or resting. The brain activity is classified each second by a neural network and the classification is sent to a pendulum simulator to change the force applied to the pendulum. The state of the inverted pendulum is shown to the subject in a pair of VR goggles. The subject was able to balance the inverted pendulum during several minutes, both with real activity and imagined activity. In each classification 9000 brain voxels were used and the response time for the system to detect a change of activity was on average 2-4 seconds. The developments here have a potential to aid people with communication disabilities, such as locked in people. Another future potential application can be to serve as a tool for stroke and Parkinson patients to be able to train the damaged brain area and get real-time feedback for more efficient training.
8.	Eklund, Anders, 1981-, et al. (author) Using Real-Time fMRI to Control a Dynamical System by Brain Activity Classification 2009. - 1 In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642042676 - 9783642042683 ; , s. 1000-1008 Conference paper (peer-reviewed)abstract We present a method for controlling a dynamical system using real-time fMRI. The objective for the subject in the MR scanner is to balance an inverted pendulum by activating the left or right hand or resting. The brain activity is classified each second by a neural network and the classification is sent to a pendulum simulator to change the force applied to the pendulum. The state of the inverted pendulum is shown to the subject in a pair of VR goggles. The subject was able to balance the inverted pendulum during several minutes, both with real activity and imagined activity. In each classification 9000 brain voxels were used and the response time for the system to detect a change of activity was on average 2-4 seconds. The developments here have a potential to aid people with communication disabilities, such as locked in people. Another future potential application can be to serve as a tool for stroke and Parkinson patients to be able to train the damaged brain area and get real-time feedback for more efficient training.
9.	Hergens, Maria-Pia, et al. (author) Use of Scandinavian Moist Smokeless Tobacco (Snus) and the Risk of Atrial Fibrillation 2014 In: Epidemiology. - 1044-3983 .- 1531-5487. ; 25:6, s. 872-876 Journal article (peer-reviewed)abstract BACKGROUND: Snus is a smokeless tobacco product, widely used among Swedish men and increasingly so elsewhere. There is debate as to whether snus is an acceptable "harm-reduction" tobacco product. Since snus use delivers a dose of nicotine equivalent to cigarettes, and has been implicated in cardiac arrhythmia because of associations with sudden cardiovascular death, a relation with atrial fibrillation is plausible and important to investigate.METHODS:: To assess the relation between use of snus and risk of atrial fibrillation, we carried out a pooled analysis of 7 prospective Swedish cohort studies. In total, 274,882 men, recruited between 1978 and 2004, were followed via the National Patient Register for atrial fibrillation. Primary analyses were restricted to 127,907 never-smokers. Relative risks were estimated using Cox proportional hazard regression.RESULTS:: The prevalence of snus use was 25% among never-smokers. During follow-up, 3,069 cases of atrial fibrillation were identified. The pooled relative risk of atrial fibrillation was 1.07 (95% confidence interval = 0.97-1.19) in current snus users, compared with nonusers.CONCLUSION:: Findings from this large national pooling project indicate that snus use is unlikely to confer any important increase in risk of atrial fibrillation.
10.	Knutsson, Anders, et al. (author) Shift work and diabetes - A systematic review 2014 In: Chronobiology International. - : Informa UK Limited. - 0742-0528 .- 1525-6073. ; 31:10, s. 1146-1151 Research review (peer-reviewed)abstract Diabetes mellitus is a chronic disease, which has an increasing trend all over the world. Type 2 diabetes constitutes 90% of all diabetes. It is associated with weight gain and insulin resistance. Research during recent years has suggested that shift work could be a risk factor of type 2 diabetes. Since shift work is becoming more common, it could contribute to the increasing trend of diabetes. In this systematic review, we have studied the potential association between shift work and type 2 diabetes. We have also reviewed studies on control of diabetes in relation to shift work.
11.	Lundström, Claes, 1973-, et al. (author) The alpha-histogram: Using Spatial Coherence to Enhance Histograms and Transfer Function Design 2006 In: Proceedings Eurographics/IEEE Symposium on Visualization 2006, Lisbon, Portugal. ; , s. 227-234 Conference paper (other academic/artistic)abstract The high complexity of Transfer Function (TF) design is a major obstacle to widespread routine use of Direct Volume Rendering, particularly in the case of medical imaging. Both manual and automatic TF design schemes would benefit greatly from a fast and simple method for detection of tissue value ranges. To this end, we introduce the a-histogram, an enhancement that amplifies ranges corresponding to spatially coherent materials. The properties of the a-histogram have been explored for synthetic data sets and then successfully used to detect vessels in 20 Magnetic Resonance angiographies, proving the potential of this approach as a fast and simple technique for histogram enhancement in general and for TF construction in particular.
12.	Nguyen, Tan Khoa, et al. (author) Concurrent Volume Visualization of Real-Time fMRI 2010 In: Proceedings of the 8th IEEE/EG International Symposium on Volume Graphics. - Goslar, Germany : Eurographics - European Association for Computer Graphics. - 9783905674231 ; , s. 53-60 Conference paper (peer-reviewed)abstract We present a novel approach to interactive and concurrent volume visualization of functional Magnetic Resonance Imaging (fMRI). While the patient is in the scanner, data is extracted in real-time using state-of-the-art signal processing techniques. The fMRI signal is treated as light emission when rendering a patient-specific high resolution reference MRI volume, obtained at the beginning of the experiment. As a result, the brain glows and emits light from active regions. The low resolution fMRI signal is thus effectively fused with the reference brain with the current transfer function settings yielding an effective focus and context visualization. The delay from a change in the fMRI signal to the visualization is approximately 2 seconds. The advantage of our method over standard 2D slice based methods is shown in a user study. We demonstrate our technique through experiments providing interactive visualization to the fMRI operator and also to the test subject in the scanner through a head mounted display.
13.	Nyrén, Olof, et al. (author) Smoking and colorectal cancer : a 20 year follow-up study of Swedish construction workers 1996 In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 88:18, s. 1302-1307 Journal article (peer-reviewed)
14.	Ohlsson, Henrik, 1981-, et al. (author) Enabling Bio-Feedback using Real-Time fMRI 2008 In: 47th IEEE Conference on Decision and Control, 2008, CDC 2008. - Linköping : IEEE. - 9781424431236 ; , s. 3336-3341 Conference paper (peer-reviewed)abstract Despite the enormous complexity of the human mind, fMRI techniques are able to partially observe the state of a brain in action. In this paper we describe an experimental setup for real-time fMRI in a bio-feedback loop. One of the main challenges in the project is to reach a detection speed, accuracy and spatial resolution necessary to attain sufficient bandwidth of communication to close the bio-feedback loop. To this end we have banked on our previous work on real-time filtering for fMRI and system identification, which has been tailored for use in the experiment setup. In the experiments presented the system is trained to estimate where a person in the MRI scanner is looking from signals derived from the visual cortex only. We have been able to demonstrate that the user can induce an action and perform simple tasks with her mind sensed using real-time fMRI. The technique may have several clinical applications, for instance to allow paralyzed and "locked in" people to communicate with the outside world. In the meanwhile, the need for improved fMRI performance and brain state detection poses a challenge to the signal processing community. We also expect that the setup will serve as an invaluable tool for neuro science research in general.
15.	Romelsjö, Anders, et al. (author) Dags kräva stopp för utarmat uran i vapen 2012 In: Goeteborgs - Posten. - 1103-9345. Journal article (pop. science, debate, etc.)abstract Vapenprojektiler och pansar dopat med uran kan orsaka cancer, missbildningar och död hos den som hanterar eller utsätts för dem. Svenska folket måste nu få veta om sådana vapen tillverkas av Bofors och om svenska soldater kommit i kontakt med dem. Det är också hög tid för riksdagen att verka för ett förbud mot dessa vapen, skriver bland andra professor Anders Romelsjö.
16.	Salomonsson, T., et al. (author) Abnormal cerebral hemodynamics and blood-brain barrier permeability detected with perfusion MRI in systemic lupus erythematosus patients 2023 In: NeuroImage: Clinical. - : Elsevier BV. - 2213-1582. ; 38 Journal article (peer-reviewed)abstract Objective: Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) has previously shown alterations in cerebral perfusion in patients with systemic lupus erythematosus (SLE). However, the results have been inconsistent, in particular regarding neuropsychiatric (NP) SLE. Thus, we investigated perfusion-based measures in different brain regions in SLE patients with and without NP involvement, and additionally, in white matter hyperintensities (WMHs), the most common MRI pathology in SLE patients. Materials and methods: We included 3 T MRI images (conventional and DSC) from 64 female SLE patients and 19 healthy controls (HC). Three different NPSLE attribution models were used: the Systemic Lupus International Collaborating Clinics (SLICC) A model (13 patients), the SLICC B model (19 patients), and the American College of Rheumatology (ACR) case definitions for NPSLE (38 patients). Normalized cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) were calculated in 26 manually drawn regions of interest and compared between SLE patients and HC, and between NPSLE and non-NPSLE patients. Additionally, normalized CBF, CBV and MTT, as well as absolute values of the blood-brain barrier leakage parameter (K2) were investigated in WMHs compared to normal appearing white matter (NAWM) in the SLE patients. Results: After correction for multiple comparisons, the most prevalent finding was a bilateral significant decrease in MTT in SLE patients compared to HC in the hypothalamus, putamen, right posterior thalamus and right anterior insula. Significant decreases in SLE compared to HC were also found for CBF in the pons, and for CBV in the bilateral putamen and posterior thalamus. Significant increases were found for CBF in the posterior corpus callosum and for CBV in the anterior corpus callosum. Similar patterns were found for both NPSLE and non-NPSLE patients for all attributional models compared to HC. However, no significant perfusion differences were revealed between NPSLE and non-NPSLE patients regardless of attribution model. The WMHs in SLE patients showed a significant increase in all perfusion-based metrics (CBF, CBV, MTT and K2) compared to NAWM. Conclusion: Our study revealed perfusion differences in several brain regions in SLE patients compared to HC, independently of NP involvement. Furthermore, increased K2 in WMHs compared to NAWM may indicate blood-brain barrier dysfunction in SLE patients. We conclude that our results show a robust cerebral perfusion, independent from the different NP attribution models, and provide insight into potential BBB dysfunction and altered vascular properties of WMHs in female SLE patients. Despite SLE being most prevalent in females, a generalization of our conclusions should be avoided, and future studies including all sexes are needed.
17.	Sjödin, Fredrik, et al. (author) Measures against preschool noise and its adverse effects on the personnel : an intervention study 2014 In: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 87:1, s. 95-110 Journal article (peer-reviewed)abstract The aim of the study was to analyze the exposure effects of different types of noise measures carried out at preschools. The project was carried out as an intervention study. The investigation included 89 employees at 17 preschools in the northern part of Sweden. Individual noise recordings and recordings in dining rooms and play halls were made at two departments in each preschool. The adverse effects on the employees were analyzed with validated questionnaires and saliva cortisol samples. Evaluations were made before and 1 year after the first measurement. Between the two measurements, measures were taken to improve the sound environments at the preschools. The effects of the measures varied a lot, with respect to both the sound environments and health. Regarding acoustical measures, significant changes were seen for some of the variables analyzed. For most of the tested effects, the changes, however, were very small and non-significant. The effects of organizational measures on the objective and subjective noise values were in overall less pronounced. Acoustical measures improved the subjectively rated sound environment more than organizational measures. This may be due to the high work effort needed to implement organizational measures. Even though the sound level was not lower, the personnel experienced improvements of the sound environment.
18.	Sjödin, Fredrik, et al. (author) Minimizing speech contribution using different microphone noise dosimeter positions 2012 In: Proceedings of BNAM 2012. - Odense : University of Southern Denmark. - 9788799540006 Conference paper (other academic/artistic)abstract Use of noise dosimeter recordings in low sound level environments is often problematic due to the voice contribution from the carrier. The aim of the study was to find a microphone position with low speech contribution while still providing an accurate sound level recording. An experiment with different microphone positions was conducted in a low sound reverberation room. Two types of noise dosimeters were used (Brüel & Kjaer 4445 and Larson Davis Spark 706-Atex). In repeated measurements the carrier was instructed to read a text chapter during 60 seconds and at a speech of level about 60 dB(A), acquired by practice, with different background noise and noise levels. White noise and preschool noise was used at sound levels 50, 60, 70 and 80 dB(A). The voice contribution to the background noise level was then measured. Three microphone positions were tested; on the shoulder, above the ear and on the back of the head. The position with the microphone placed behind the head of the carrier had the lowest speech contribution, less than 2 dB(A) to the background noise at 70 dB(A). This compared to positions right above the ear 6 dB(A and on the shoulder 12 dB(A).
19.	Sjödin, Fredrik, et al. (author) Noise and stress effects on preschool personnel 2012 In: Noise & Health. - : Medknow. - 1463-1741 .- 1998-4030. ; 14:59, s. 166-178 Journal article (peer-reviewed)abstract The aim of the study was to analyze the presence of stress-related health problems among preschool employees and the way in which these reactions are related to noise and other work parameters. The investigation included 101 employees at 17 preschools in Umea County, located in northern Sweden. Individual noise recordings and recordings in dining rooms and play halls were made at two departments from each preschool. The adverse effects on the employees were analyzed by use of different validated questionnaires and by saliva cortisol samples. Stress and energy output were pronounced among the employees, and about 30 of the staff experienced strong burnout syndromes. Mental recovery after work was low, indicated by remaining high levels of stress after work. The burnout symptoms were associated with reduced sleep quality and morning sleepiness. Cortisol levels supported the conclusion about pronounced daily stress levels of the preschool employees.
20.	Sjödin, Fredrik, et al. (author) Noise exposure and auditory effects on preschool personnel 2012 In: Noise & Health. - : Medknow Publications. - 1463-1741 .- 1998-4030. ; 14:57, s. 72-82 Journal article (peer-reviewed)abstract Hearing impairments and tinnitus are being reported in an increasing extent from employees in the preschool. The investigation included 101 employees at 17 preschools in Umeå county, Sweden. Individual noise recordings and stationary recordings in dining rooms and play halls were conducted at two departments per preschool. The effects of noise exposures were carried out through audiometric screenings and by use of questionnaires. The average individual noise exposure was close to 71 dB(A), with individual differences but small differences between the preschools. The noise levels in the dining room and playing halls were about 64 dB(A), with small differences between the investigated types of rooms and preschools. The hearing loss of the employees was significantly higher for the frequencies tested when compared with an unexposed control group in Sweden. Symptoms of tinnitus were reported among about 31% of the employees. Annoyance was rated as somewhat to very annoying. The voices of the children were the most annoying noise source. The dB(A) level and fluctuation of the noise exposure were significantly correlated to the number of children per department. The preschool sound environment is complex and our findings indicate that the sound environment is hazardous regarding auditory disorders. The fluctuation of the noise is of special interest for further research.
21.	Sjödin, Fredrik, 1978- (author) Noise in the preschool : health and preventive measures 2012 Doctoral thesis (other academic/artistic)abstract This thesis is based on noise recordings and health evaluations carried out at preschools in the northern part of Sweden. Sound level recordings were made on individuals and by use of stationary devices in dining rooms and play halls. Health evaluations were based on ratings by use of questionnaires and by analyses of cortisol.The average equivalent individual noise exposure was 71 dB(A). The average equivalent noise levels in the dining room and playing halls were 64 dB(A). The hearing loss of the employees was significantly higher for the frequencies tested than in an unexposed control group. Symptoms of tinnitus were reported among 31% of the employees. Noise annoyance was rated as somewhat to very annoying, and the voices of the children were the most annoying noise source. The dB(A) level and fluctuations of the noise exposure were significantly correlated with the number of children per department. Stress and energy output were pronounced among the employees. About 30% of the staff experienced strong burnout syndromes. Mental recovery was low as indicated by noise fatigue and high levels of stress after work. Increased cortisol levels during work were associated with higher number of children present at the department.An essential finding of the thesis was that noise and noise sources may impair the pedagogic work, thereby increasing the work load of employees. It is concluded that noise exposure in the preschool, isolated or in combination with other stressors, plays a fundamental role in the building up of acute as well as long term stress. An intervention study implementing six acoustical and seven organizational measures was tested, aimed to improve the noise situation in the departments. Acoustical measures improved the noise situation as well as the rated noise experiences better than the organizational measures.
22.	Sjödin, Fredrik, et al. (author) Tinnitus, noise and health effects in preschool environments 2012 In: Proceedings of BNAM 2012. - Odense : University of Southern Denmark. - 9788799540006 Conference paper (other academic/artistic)abstract The study included 93 employees at 17 preschools in the county of Umeå located in northern part ofSweden. Personal daily noise dosimeter recordings were made at five representative work days.Stationary noise recordings were made during the same days at two departments of each preschool, in theplaying halls and in the dining rooms. Besides audiometric tests, the employees rated their experiences ofthe noise, hearing and tinnitus as well as well as different health effects, on validated questionnaires.Tinnitus was reported among 31 per cent of the participants. The study group was dichotomized intoemployees with or without tinnitus. Employees with tinnitus reported higher prevalence of subjectivehearing loss, higher experiences of elevated sound levels at work, anxiety of the noise at work, chestpressure/pain, burn out symptoms, depression and reduced sleep quality. Significant differences wereseen for shoulder tension/pain. No group differences were seen for the objective personal or stationarynoise measures or the number of children present at the department. The results of the study are discussedin terms of underlying causes and the way in which the symptom interfere with experiences and healtheffects of the employees.
23.	Sjödin, Fredrik, et al. (author) Work related stress and stressors in the preschool environment Other publication (other academic/artistic)abstract The study included six departments, with two employees at each department, characterized by high levels of stress and burnout and six departments, with two employees at each department, characterized by low levels of stress andburnout. A total of 24 females with a mean age of 43.5 years participated in the study. The employees rated stress at work and burnout by use of different questionnaires. Cortisol samples were collected at wake up, one hour afterwake up, at 11:00 am and at 09:00 pm. An observation study was made to create an overview of the interactionbetween the children and the personnel during periods described as overloading.More than 50% of the employees stated that all members of the staff did not have equal commitment to the work. About 8% considered this stressful to a high degree. More than half found their increased administrative work task as stressful to a high degree. Half of the personnel felt it stressful to a high degree, not being able to give all the children the attention they needed.The highest stressors regarding the organization of the work were when conflicts occurred among the personnel. The highest stressors regarding noise were the children´s voices closely followed by noise when changing the children´sclothes. The highest stressor regarding the constitution of the child group was when the personnel experienced that they had a child in the group they thought needed special support. In general, the high stress group rated all stressors as higher compared to the low stress group. Significant differences were pronounced among stressors regarding“organization of the work” and “work situations”. The results also indicate that individuals who are highly stressed by noise from the childrens activities rated their rewards as lower. The high stress group had more communications to and from the children, both before lunch and during lunch.An essential conclusion, is also that noise and noise sources, may impair the work situation of the employees fundamentally, thereby increasing the stress levels. It is assumed that noise exposures in the preschool, isolated or in combination with other stressor, plays a fundamental role in the building up acute as well as long term stress. One of the stand points of the study is that overloaded communication between the personnel and children might be a pronounced factor behind the situational and longterm stress.
24.	Sundström, Johan, Professor, 1971-, et al. (author) Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults 2019 In: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 48:6, s. 2018-2025 Journal article (peer-reviewed)abstract BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium.METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries.RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH.CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives.
25.	Abramian, David, 1992-, et al. (author) Anatomically Informed Bayesian Spatial Priors for FMRI Analysis 2020 In: ISBI 2020. - : IEEE. - 9781538693308 Conference paper (peer-reviewed)abstract Existing Bayesian spatial priors for functional magnetic resonance imaging (fMRI) data correspond to stationary isotropic smoothing filters that may oversmooth at anatomical boundaries. We propose two anatomically informed Bayesian spatial models for fMRI data with local smoothing in each voxel based on a tensor field estimated from a T1-weighted anatomical image. We show that our anatomically informed Bayesian spatial models results in posterior probability maps that follow the anatomical structure.
26.	Alfredsson, Lars, et al. (author) Job strain and major risk factors for coronary heart disease. : Baseline results from the WOLF Study 2002 In: Scandinavian Journal of Work, Environment & Health. - 0355-3140. ; 28:4, s. 238-248 Journal article (peer-reviewed)abstract The results do not support the hypothesis that job strain has an adverse impact on serum total cholesterol and plasma fibrinogen levels. They suggest that an increased risk of coronary heart disease in association with job strain, if causal, is mediated by other factors, possibly partly by hypertension and low levels of high-density lipoprotein cholesterol.
27.	Alfredsson, Lars, et al. (author) Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen. 2002 In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 28:4, s. 238-248 Journal article (peer-reviewed)
28.	Allwood, Carl Martin, et al. (author) Contagious contacts: How police trainees influence each other’s memories for a criminal event 2004 In: Paper presented at the 14th European Conference on Psychology and Law of the EAP & L Crakow, Polen, July 7–10, 2004. Conference paper (peer-reviewed)abstract This study investigated the effect of confirmatory and disconfirmatory feedback on the accuracy (realism) in witnesses’ confidence judgements of their event memory. After watching a short video of a kidnapping the participants answered 44 two-alternative questions on the videotape. Two weeks later the participants were handed their old question-answering sheet with the original questions and their own answers. In addition feedback was provided in writing for each answer. The participants were asked to give confidence ratings with respect to the correctness of each answer. In the Control condition the participants received no feedback. Overall, the witnesses’ confidence ratings showed overconfidence in all conditions. Furthermore, confirmatory feedback caused higher overconfidence, compared both with disconfirmatory feedback and no feedback. The results show that the realism in the eyewitnesses’ confidence judgements of their event memory is indeed sensitive to co-witness feedback, especially to confirming feedback.
29.	Allwood, Carl Martin, et al. (author) Eyewitness under influence: How feedback affect the realism in confidence 2004 Conference paper (peer-reviewed)
30.	Allwood, Carl Martin, 1952, et al. (author) Eyewitnesses under influence: How feedback affect the realism in confidence 2006 In: Psychology, Crime & Law. - : Informa UK Limited. ; 12:1, s. 25-38 Journal article (peer-reviewed)abstract This study investigated the effect of two types of feedback (confirmatory and disconfirmatory) on the accuracy in witness’ confidence judgements of their event memory. Overall the witnesses evidenced overconfidence both when they received feedback and in the control condition (no feedback). The results showed that confirmatory feedback caused higher overconfidence, compared both with when receiving disconfirmatory and no feedback. The results suggest that the impact of feedback on the accuracy of confidence judgments show the same pattern of results for event memory as for line-up identification tasks. Finally, when witnesses rated the total number of questions that they had answered correctly they gave fairly correct estimates compared with their actual number of correct answers.
31.	Allwood, Carl Martin, 1952, et al. (author) Eyewitnesses under influence: How feedback affects the realism in confidence judgements. 2004 In: Oral paper presented at the 14th European Conference on Psychology and Law (Cracow, Poland). Conference paper (peer-reviewed)abstract Witnesses often discuss the witnessed event with other witnesses. Hence, it is important to increase our understanding of how co-witness feedback affects witnesses memory and meta-memory. This study investigated the effect of confirmatory and disconfirmatory feedback on the accuracy in witnesses confidence judgements. A general conclusion from the study is that the realism in the witnesses confidence judgements is indeed sensitive to co-witness feedback, and more so to confirming than disconfirming feedback.
32.	Amarenco, Pierre, et al. (author) Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke : A Randomized Clinical Trial 2020 In: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 78:2, s. 177-185 Journal article (peer-reviewed)abstract Importance: Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke.Objective: To evaluate the superiority of ticagrelor added to aspirin in preventing disabling stroke and to understand the factors associated with recurrent disabling stroke.Design, Setting, and Participants: The Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) was a randomized clinical trial conducted between January 22, 2018, and December 13, 2019, with a 30-day follow-up, at 414 hospitals in 28 countries. The trial included 11 016 patients with a noncardioembolic, nonsevere ischemic stroke or high-risk TIA, including 10 803 with modified Rankin Scale score (mRS) recorded at 30 days.Interventions: Ticagrelor (180-mg loading dose on day 1 followed by 90 mg twice daily for days 2-30) or placebo within 24 hours of symptom onset. All patients received aspirin, 300 to 325 mg on day 1 followed by 75 to 100 mg daily for days 2 to 30.Main Outcomes and Measures: Time to the occurrence of disabling stroke (progression of index event or new stroke) or death within 30 days, as measured by mRS at day 30. Disabling stroke was defined by mRS greater than 1.Results: Among participants with 30-day mRS greater than 1, mean age was 68.1 years, 1098 were female (42.6%), and 2670 had an ischemic stroke (95.8%) as a qualifying event. Among 11 016 patients, a primary end point with mRS greater than 1 at 30 days occurred in 221 of 5511 patients (4.0%) randomized to ticagrelor and in 260 of 5478 patients (4.7%) randomized to placebo (hazard ratio [HR], 0.83; 95% CI, 0.69-0.99, P = .04). A primary end point with mRS 0 or 1 at 30 days occurred in 70 of 5511 patients (1.3%) and 87 of 5478 patients (1.6%) (HR, 0.79; 95% CI, 0.57-1.08; P = .14). The ordinal analysis of mRS in patients with recurrent stroke showed a shift of the disability burden following a recurrent ischemic stroke in favor of ticagrelor (odds ratio, 0.77; 95% CI, 0.65-0.91; P = .002). Factors associated with disability were baseline National Institutes of Health Stroke Scale score 4 to 5, ipsilateral stenosis of at least 30%, Asian race/ethnicity, older age, and higher systolic blood pressure, while treatment with ticagrelor was associated with less disability.Conclusions and Relevance: In patients with TIA and minor ischemic stroke, ticagrelor added to aspirin was superior to aspirin alone in preventing disabling stroke or death at 30 days and reduced the total burden of disability owing to ischemic stroke recurrence.Trial Registration: ClinicalTrials.gov Identifier: NCT03354429.
33.	Amarenco, Pierre, et al. (author) Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin 2020 In: Stroke. - 0039-2499 .- 1524-4628. ; 51:12, s. 3504-3513 Journal article (peer-reviewed)abstract Background and Purpose:Among patients with a transient ischemic attack or minor ischemic strokes, those with ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk of recurrent vascular events.Methods:In the double-blind THALES (The Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death) trial, we randomized patients with a noncardioembolic, nonsevere ischemic stroke, or high-risk transient ischemic attack to ticagrelor (180 mg loading dose on day 1 followed by 90 mg twice daily for days 2–30) or placebo added to aspirin (300–325 mg on day 1 followed by 75–100 mg daily for days 2–30) within 24 hours of symptom onset. The present paper reports a prespecified analysis in patients with and without ipsilateral, potentially causal atherosclerotic stenosis ≥30% of cervicocranial vasculature. The primary end point was time to the occurrence of stroke or death within 30 days.Results:Of 11 016 randomized patients, 2351 (21.3%) patients had an ipsilateral atherosclerotic stenosis. After 30 days, a primary end point occurred in 92/1136 (8.1%) patients with ipsilateral stenosis randomized to ticagrelor and in 132/1215 (10.9%) randomized to placebo (hazard ratio 0.73 [95% CI, 0.56–0.96], P=0.023) resulting in a number needed to treat of 34 (95% CI, 19–171). In patients without ipsilateral stenosis, the corresponding event rate was 211/4387 (4.8%) and 230/4278 (5.4%), respectively (hazard ratio, 0.89 [95% CI, 0.74–1.08]; P=0.23, Pinteraction=0.245). Severe bleeding occurred in 4 (0.4%) and 3 (0.2%) patients with ipsilateral atherosclerotic stenosis on ticagrelor and on placebo, respectively (P=NS), and in 24 (0.5%) and 4 (0.1%), respectively, in 8665 patients without ipsilateral stenosis (hazard ratio=5.87 [95% CI, 2.04–16.9], P=0.001).Conclusions:In this exploratory analysis comparing ticagrelor added to aspirin to aspirin alone, we found no treatment by ipsilateral atherosclerosis stenosis subgroup interaction but did identify a higher absolute risk and a greater absolute risk reduction of stroke or death at 30 days in patients with ipsilateral atherosclerosis stenosis than in those without. In this easily identified population, ticagrelor added to aspirin provided a clinically meaningful benefit with a number needed to treat of 34 (95% CI, 19–171).
34.	Andersson, Eva, 1955, et al. (author) Incidence of asthma among workers exposed to sulfur dioxide and other irritant gases 2006 In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 27:4, s. 720-5. Journal article (peer-reviewed)abstract The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO2) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire. The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age. The incidence rate for asthma among sulphite mill workers reporting gassings of SO2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO2, the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males. In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.
35.	Andersson, Jacob, et al. (author) Virtual reality exposure therapy for fear of spiders: an open trial and feasibility study of a new treatment for arachnophobia In: Nordic Journal of Psychiatry. - 1502-4725. ; , s. 1-9 Journal article (peer-reviewed)
36.	Andersson, Mitchell J., et al. (author) Concussion history associated with adolescent psychological distress but not hazardous gambling : a cross-sectional study 2024 In: BMC Psychology. - 2050-7283. ; 12:1, s. 1-10 Journal article (peer-reviewed)abstract BackgroundSustaining multiple concussions over one’s lifetime may be associated with behavioral and mood changes beyond the acute phase of injury. The present cross-sectional study examined the relationship between concussion history, the incidence of current moderate-severe psychological distress, and lifetime adolescent hazardous gambling in high school students.MethodsFour-hundred fifty-nine high school students from southern Sweden (age: 16.81 ± 0.83, 58.2% male) completed a survey assessing concussion history (0,1,2…>8), psychological distress using the Kessler-6 scale, and lifetime hazardous gambling using the NODS-CLiP scale.ResultsParticipants who self-reported three or more concussions were more likely to endorse moderate-severe symptoms of psychological distress than those with no concussion history while controlling for covariates, OR = 2.71, 95% CI [1.19, 6.18]. In contrast, concussion history was not associated with hazardous gambling after controlling for confounding variables.ConclusionsSelf-reporting three or more concussions was associated with increased current psychological distress beyond the acute phase of injury among high school students. Adolescents who have sustained multiple concussions should undergo mental health evaluations beyond the acute phase of injury to identify and treat psychological distress, but probing for hazardous gambling may not be clinically relevant in this previously concussed adolescent population.
37.	Andersson, Mitchell, et al. (author) Symptoms of depression and anxiety among elite high school student-athletes in Sweden during the COVID-19 pandemic : A repeated cross-sectional study 2023 In: Journal of Sports Sciences. - : Taylor & Francis. - 0264-0414 .- 1466-447X. ; 41:9, s. 874-883 Journal article (peer-reviewed)abstract The COVID-19 pandemic precipitated numerous changes in daily life, including the cancellation and restriction of sports globally. Because sports participation contributes positively to the development of student-athletes, restricting these activities may have led to long-term mental health changes in this population. Using a repeated cross-sectional study design, we measured rates of depression using the Patient Health Questionnaire-2 and anxiety using the Generalized Anxiety Disorder-2 scale in student-athletes attending elite sport high schools in Sweden during the second wave of the pandemic (February 2021; n = 7021) and after all restrictions were lifted (February 2022; n = 6228). Depression among student-athletes decreased from 19.8% in 2021 to 17.8% in 2022 (p = .008, V = .026), while anxiety screening did not change significantly (17.4% to 18.4%, p > .05). Comparisons between classes across years revealed older students exhibited decreases in depressive symptoms, while younger cohorts experienced increases in symptoms of anxiety from 2021 to 2022. Logistic regressions revealed that being female, reporting poorer mental health due to COVID-19, and excessive worry over one’s career in sports were significant predictors of both depression and anxiety screenings in 2022. Compared to times when sports participation was limited, the lifting of restrictions was associated with overall reduced levels of depression, but not anxiety.
38.	André, Frida, et al. (author) A cross-sectional study on extensive gaming in adolescents 2022 In: Journal of Public Health Research. - : SAGE Publications. - 2279-9028 .- 2279-9036. ; 11:1 Journal article (peer-reviewed)abstract BACKGROUND: Extensive gaming and the consequences thereof is frequently reported from child and adolescent psychiatry and school health care. The behavior is associated with compulsion, psychiatric and physical symptoms, impaired cognitive development and poorer school performance. This phenomenon has been described as an emergent health issue for men and little is known about its potential gender-specific characteristics. The aim of this study was to explore extensive gaming among male and female adolescents and to investigate whether the frequency of often feeling low, often feeling anxious, self-reported ADHD, self-reported ASD, being satisfied with one's own general health, poor sleep, loneliness, and having tried smoking, alcohol, and/or other substances differed among those with and without extensive gaming.DESIGN AND METHODS: This study was based on data collected through a public health survey distributed in 2016 to pupils in 9th grade of primary school and in second grade of secondary school, including a total of 13498 participants. The association between extensive gaming and different factors was estimated among male and female respondents separately.RESULTS: Roughly 30% of the male and 5% of the female respondents were categorized as extensive gamers. Extensive gaming was associated with a higher prevalence of poor sleep and a lower prevalence of being satisfied with one's own health among boys and (to a higher degree) among girls.CONCLUSIONS: Altogether, our results contribute to the impression that extensive gaming is more heavily related to subjective health complaints among female than male adolescents.
39.	André, Frida, et al. (author) Cognitive behavioral treatment for disordered gaming and problem gambling in adolescents : a pilot feasibility study 2022 In: Upsala Journal of Medical Sciences. - 0300-9734. ; 127 Journal article (peer-reviewed)abstract Background: Disordered gaming and problem gambling (DG/PG) are associated with a range of functional impairments as well as psychiatric comorbidity. With the proliferation of digital gaming apps aimed at children and adolescents, which involve in-game purchases, there is increasing evidence that DG/PG are on the rise in this age range. The behavior can be detected in youth presenting at school-based health clinics and community psychiatric clinics. Cognitive behavioral therapy (CBT) is one of several recommended treatments for adults, but little evidence is available for the efficacy of this approach in adolescents with DG/PG. Aim: To evaluate the acceptability and feasibility of a CBT-based intervention developed for adolescents with DG/PG, which can be delivered in routine psychiatric care facilities. Methods: Adolescents who were patients at a child and adolescent psychiatry service were screened for DG/PG. Those aged 12-17 years with pronounced symptoms were invited to participate in a 7-week CBT program called Relapse Prevention. Nine adolescents agreed to participate and five consented to repeated assessments of outcome (pre-, post-treatment, and 6-month follow-up). In addition to acceptability and satisfaction with treatment, symptoms of DG were assessed with standardized interview and self-report measures. Results: There were no dropouts from the treatment. Participants who completed treatment and all outcome assessments reported satisfaction with the treatment. The participants showed fewer symptoms of DG after treatment, and the proportion who met criteria for computer game addiction decreased from 56 to 0%. There was no reduction in the number of participants who met criteria for PG. Conclusion: This study provides preliminary evidence for the acceptability and feasibility of a CBT-based intervention for DG/PG in adolescents. Preliminary data suggest that the treatment may be effective for DG but not PG. Further studies are needed to evaluate the efficacy of this approach for both conditions.
40.	André, Frida, et al. (author) Game Addiction Scale for Adolescents-Psychometric Analyses of Gaming Behavior, Gender Differences and ADHD 2022 In: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 13 Journal article (peer-reviewed)abstract BackgroundInternet gaming disorder (IGD) was recently added in the Diagnostic and Statistical Manual of Mental Disorder as a "condition for further studies." There is no consensus regarding which rating scales should be used but many scholars suggest the GASA (Game Addiction Scale for Adolescents) and a ranking of the criteria, "the core approach" to avoid over-diagnosing of disordered gaming. Male gender and ADHD are commonly listed as risk factors for disordered gaming but little is known about sex differences in gaming and gender specific health correlates. PurposeThe present study aims to evaluate the core approach and the specific indicators of gaming behavior in GASA from a multifactorial perspective and explore the gender differences in a clinical setting, focusing on ADHD. Patients and MethodsChildren and adolescents aged 8-18 years (n = 144) from Child and adolescent psychiatry (CAP) in Skane were assessed with the GASA. Psychometric analyses including confirmatory factor analyses (CFA) and structural equation modeling (SEM) were used to identify well-defined constructs and gender differences. Refined factor scores for single constructs were the outcome of alignment, a procedure for assessing measurement equivalence across gender. New model-based gaming behavior variables were used for descriptive statistics and ANOVA testing of gender differences. ResultsThe results confirm that the core approach two-factor model is valid for the CAP sample, as well as a theory based psycho-social model for gaming behavior with over consumption and negative social and emotional consequences. Our findings suggest that negative consequences of over consumption take a social direction for boys and an emotional direction for girls. Also, ADHD was significantly associated with over consumption of video games and the negative consequences thereof for girls. ConclusionGuided by psychometric analyses, the GASA could be strengthened by advancing the questionnaire design and by adding complementary items in order to illuminate the complexity of gaming behavior. Our findings suggest that additional research on potential gender related discrepancies of disordered gaming is needed.
41.	André, Frida, et al. (author) Gaming addiction, problematic gaming and engaged gaming – Prevalence and associated characteristics 2020 In: Addictive Behaviors Reports. - : Elsevier BV. - 2352-8532. ; 12 Journal article (peer-reviewed)abstract Introduction: Gaming disorder was included in the 11th revision of the International Classification of Diseases (ICD 11) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder as a tentative diagnosis. Most scholars agree upon the potential risk for pathological use of video games. The primary aim of this study was to investigate the prevalence of engaged gamers, problem gamers and addicted gamers. The secondary aim was to describe these groups in terms of gender, age, social satisfaction, psychological wellbeing and hours spent chatting on internet/social media. Methods: We used survey-based data for this population-based research. The data was collected online in two different settings in 2017. In total 2075 participants were included. Results: 4.5 percent met the criteria for highly engaged gaming, 5.3 percent were shown to be problem gamers and 1.2 percent met the cut off for game addiction. Young age, hours chatting on internet/social media, experiencing loneliness and considering seeking treatment for psychological distress were associated with both engaged, problematic and addictive gaming. Male gender was associated to problematic and addictive gaming. Hours spent chatting showed a greater correlation to problem/addictive gaming than to engaged gaming. Conclusion: The results of this study indicate that both highly engaged gamers, problem gamers and addicted gamers all experience loneliness and psychological distress to a greater extent than the remaining study participants. This adds to the knowledge of prevalence and features of gaming disorder. Additionally, preferably longitudinal research is needed in order to understand causality.
42.	André, Frida, et al. (author) Gaming, substance use and distress within a cohort of online gamblers 2022 In: Journal of Public Health Research. - 2279-9028. ; 11:1 Journal article (peer-reviewed)abstract BACKGROUND: The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder (IGD) as a tentative diagnosis and inquires for additional research. The research on gaming is inconsistent regarding measurement approach and diagnostic cut-offs. Some scholars suggest the core approach, accentuating some of the diagnostic criteria to avoid pathologizing harmless behavior. Also, the co-occurrence of gaming and other addictions, gambling in specifically, is frequently reported but poorly understood. The present study aimed to explore gaming within a population of online gamblers in order to evaluate the core approach but also to investigate the possible co-occurrence of different addictions.DESIGN AND METHODS: The present study is derived from material collected for a study on online gambling. The study addressed 1007 adult individuals from the general population who had gambled for money on an online casino site or an online betting site, on at least 10 occasions during the past 12 months.RESULTS: Both the level of distress and problem gambling increased as the severity of gaming increased. The co-occurrence of problems with alcohol, illicit drug use/prescription sedatives/strong painkillers and gambling was roughly 50% among the addictive gamers.CONCLUSION: The present study suggests that the core approach manages to distinguish in severity of gaming in regards to interference and comorbidity. We also brought light to the occurrence of gaming within a population of gamblers and our results indicate that this specific group of addicted gamers are particularly burdened by co-occurrent addictive behaviors and severe distress.
43.	André, Frida, et al. (author) Relapse prevention therapy for internet gaming disorder in Swedish child and adolescent psychiatric clinics : a randomized controlled trial 2023 In: Frontiers in Psychiatry. - 1664-0640. ; 14 Journal article (peer-reviewed)abstract Objectives: To evaluate the effectiveness of relapse prevention (RP) as a treatment for internet gaming disorder (IGD).Design: Randomized controlled trial.Setting: Three child and adolescent psychiatry (CAP) units in Region Skåne, Sweden.Participants: Children aged 13-18 years, coming for their first visit to CAP during 2022, were screened for gaming behavior. Those who met the proposed DSM-5 criteria for IGD were offered participation in the trial, if they had the capacity to provide written informed consent and if they spoke Swedish. A total of 111 CAP patients agreed to participate. Out of those, 11 patients were excluded due to incorrect inclusion such as young age (n = 1), or due to the absence of responses to follow-up measures (n = 9). After exclusion, 102 participants remained (intervention = 47, control = 55).Interventions: The intervention, RP, is based on cognitive behavioral treatment (CBT) and was provided individually, comprising of five to seven 45-min sessions over a period of 5 to 7 weeks versus treatment as usual.Outcome measures: Participants were assessed with Game Addiction Scale for Adolescents pre-treatment (GASA) (baseline), post-treatment (treatment group only), and 3 months after baseline (follow-up).Results: The repeated measures ANOVA showed a significant interaction effect between treatment and time. Both the control group and treatment group lowered their mean GASA score from baseline to follow-up significantly, but the improvement was greater in the treatment group (mean difference in control group -5.1, p < 0.001, 95% CI = - 3.390 to -6.755, mean difference in treatment group -9.9, p < 0.001, 95% CI = -11.746 to -8.105).Conclusion: RP was found to be superior to treatment as usual in terms of reduction of IGD symptoms. Future research should address which aspects within a given treatment are effective, who benefits from treatment, in what aspects, and why.
44.	André, Frida, et al. (author) The prevalence of gaming and gambling in a child and adolescent psychiatry unit 2022 In: Journal of Public Health Research. - : SAGE Publications. - 2279-9028 .- 2279-9036. ; 11:2 Journal article (peer-reviewed)abstract Background:Gaming and gambling are frequently reported from child and adolescent psychiatry and school health care. Swedish epidemiological data show that 1.3% of the population meet the criteria for gambling disorder. Risk factors are male gender, young age, single status and being born outside Sweden. Both problem gaming and gambling are associated with compulsion, psychiatric and physical symptoms, impaired cognitive development and school performance. Based on the limited knowledge and the need for more research into these behaviours among young individuals, the present study aimed to look at the prevalence of gaming and gambling in patients at the child and adolescent psychiatry department (CAP) in Skåne, a region in the south of Sweden.Design and methods:The overall aim is to explore gaming and gambling in a child and youth population. Children aged 8–18 years (N = 144) from CAP in Skåne were assessed with two self-screening instruments: GASA (Game Addiction Scale for Adolescents) and NODS-CLiP (NORC Diagnostic Screen for Gambling Problems). Information were collected regarding type of care, housing situation and diagnosis.Results:Thirty-three percent of the study participants showed problem/addictive gaming. Fifty-two percent of the males in the study showed problem/addictive gaming. Forty-four percent of the subjects with ADHD showed problem/addictive gaming. Eleven percent of the study participants showed problem gambling.Conclusions:The present study reports hitherto unreported figures of problem gaming and gambling. Our results show the importance of screening children and adolescents for these conditions when admitting subjects to CAP in/outpatient care.
45.	Aplander, Karolina, et al. (author) Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3. 2006 In: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 341:10, s. 1363-1369 Journal article (peer-reviewed)
46.	Araghi, Marzieh, et al. (author) No association between moist oral snuff (snus) use and oral cancer : pooled analysis of nine prospective observational studies 2021 In: Scandinavian Journal of Public Health. - : Sage Publications. - 1403-4948 .- 1651-1905. ; 49:8, s. 833-840 Journal article (peer-reviewed)abstract Aims: Worldwide, smokeless-tobacco use is a major risk factor for oral cancer. Evidence regarding the particular association between Swedish snus use and oral cancer is, however, less clear. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between snus use and oral cancer.Methods: A total of 418,369 male participants from nine cohort studies were followed up for oral cancer incidence through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors.Results: During 9,201,647 person-years of observation, 628 men developed oral cancer. Compared to never-snus use, ever-snus use was not associated with oral cancer (adjusted HR 0.90, 95% CI: 0.74, 1.09). There were no clear trends in risk with duration or intensity of snus use, although lower intensity use (<= 4 cans/week) was associated with a reduced risk (HR 0.65, 95% CI: 0.45, 0.94). Snus use was not associated with oral cancer among never smokers (HR 0.87, 95% CI: 0.57, 1.32).Conclusions: Swedish snus use does not appear to be implicated in the development of oral cancer in men.
47.	Araghi, Marzieh, et al. (author) Smokeless tobacco (snus) use and colorectal cancer incidence and survival : Results from nine pooled cohorts 2017 In: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 45:8, s. 741-748 Journal article (peer-reviewed)abstract AIMS: Although smoking is considered to be an established risk factor for colorectal cancer, the current evidence on the association between smokeless tobacco and colorectal cancer is scant and inconclusive. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess this association.METHODS: A total of 417,872 male participants from nine cohort studies across Sweden were followed up for incidence of colorectal cancer and death. Outcomes were ascertained through linkage to health registers. We used shared frailty models with random effects at the study level to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: During 7,135,504 person-years of observation, 4170 men developed colorectal cancer. There was no clear association between snus use and colorectal cancer overall. Exclusive current snus users, however, had an increased risk of rectal cancer (HR 1.40: 95% CI 1.09, 1.79). There were no statistically significant associations between snus use and either all-cause or colorectal cancer-specific mortality after colorectal cancer diagnosis.CONCLUSIONS: Our findings, from a large sample, do not support any strong relationships between snus use and colorectal cancer risk and survival among men. However, the observed increased risk of rectal cancer is noteworthy, and in merit of further attention.
48.	Araghi, Marzieh, et al. (author) Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies 2017 In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:4, s. 687-693 Journal article (peer-reviewed)abstract While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer. What's new? While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. Smokeless tobacco like snus yields lower exposure to tobacco carcinogens compared with smoking, because it does not undergo combustion, but delivers an equivalent dose of nicotine. Using pooled individual data from the Swedish Collaboration on Health Effects of Snus Use, here the authors show that Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.
49.	Bhatt, Deepak L., et al. (author) Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study 2019 In: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 42:5, s. 498-505 Journal article (peer-reviewed)abstract In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.
50.	Bibic, Adnan, et al. (author) Measurement of vascular water transport in human subjects using time-resolved pulsed arterial spin labelling. 2015 In: NMR in Biomedicine. - : Wiley. - 0952-3480. ; 28:8, s. 1059-1068 Journal article (peer-reviewed)abstract Most approaches to arterial spin labelling (ASL) data analysis aim to provide a quantitative measure of the cerebral blood flow (CBF). This study, however, focuses on the measurement of the transfer time of blood water through the capillaries to the parenchyma (referred to as the capillary transfer time, CTT) as an alternative parameter to characterise the haemodynamics of the system. The method employed is based on a non-compartmental model, and no measurements need to be added to a common time-resolved ASL experiment. Brownian motion of labelled spins in a potential was described by a one-dimensional general Langevin equation as the starting point, and as a Fokker-Planck differential equation for the averaged distribution of labelled spins at the end point, which takes into account the effects of flow and dispersion of labelled water by the pseudorandom nature of the microvasculature and the transcapillary permeability. Multi-inversion time (multi-TI) ASL data were acquired in 14 healthy subjects on two occasions in a test-retest design, using a pulsed ASL sequence and three-dimensional gradient and spin echo (3D-GRASE) readout. Based on an error analysis to predict the size of a region of interest (ROI) required to obtain reasonably precise parameter estimates, data were analysed in two relatively large ROIs, i.e. the occipital lobe (OC) and the insular cortex (IC). The average values of CTT in OC were 260 ± 60 ms in the first experiment and 270 ± 60 ms in the second experiment. The corresponding IC values were 460 ± 130 ms and 420 ± 139 ms, respectively. Information related to the water transfer time may be important for diagnostics and follow-up of cerebral conditions or diseases characterised by a disrupted blood-brain barrier or disturbed capillary blood flow. Copyright © 2015 John Wiley & Sons, Ltd.

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