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1.	Konold, Patrick, et al. (author) Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs Other publication (other academic/artistic)abstract Detecting microsecond structural perturbations in biomolecules has wide relevance inbiology, chemistry, and medicine. Here, we show how MHz repetition rates at X-ray freeelectron lasers (XFELs) can be used to produce microsecond time-series of proteinscattering with exceptionally low noise levels of 0.001%. We demonstrate the approach byderiving new mechanistic insight into Jɑ helix unfolding of a Light-Oxygen-Voltage (LOV)photosensory domain. This time-resolved acquisition strategy is easy to implement andwidely applicable for direct observation of structural dynamics of many biochemicalprocesses.

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Author/Editor: Grubmueller, Helmut (1); Valerio, Joana (1); Kloos, Marco (1); Lindsten, Fredrik (1); Álvarez, Roberto (1); Bielecki, Johan (1); show more...; Bean, Richard (1); Letrun, Romain (1); Sato, Tokushi (1); Martin, Andrew (1); Bellisario, Alfredo (1); Maia, Filipe (1); Okamoto, Kenta (1); Westphal, Daniel (1); Nimmrich, Amke (1); Monrroy, Leonardo (1); Mutisya, Jennifer (1); Westenhoff, Sebastia ... (1); Konold, Patrick (1); You, Tong (1); Yenupuri, Tej Varma (1); Wollter, August (1); Mészáros, Petra (1); de Matos Filipe, Dio ... (1); Bódizs, Szabolcs (1); Ducroq, Gabriel (1); Kirian, Richard (1); Koliyadu, Jayanat (1); Koua, Faisal (1); Larkiala, Taru (1); Maihöfer, Michael (1); Adam, Round (1); show less...

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