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Search: WFRF:(Koske Iris)

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  • Bernhard, Sara, et al. (author)
  • The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.
  • 2014
  • In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 210:8, s. 1306-1310
  • Journal article (peer-reviewed)abstract
    • Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Riesbeck, Kristian (1)
Bernhard, Sara (1)
Fleury, Christophe (1)
Su, Shanice YC (1)
Zipfel, Peter (1)
Koske, Iris (1)
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Nordström, Therése (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2014 (1)

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