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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Abudurexiti, A, et al.
(author)
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Taxonomy of the order Bunyavirales: update 2019
- 2019
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In: Archives of virology. - : Springer Science and Business Media LLC. - 1432-8798 .- 0304-8608. ; 164:7, s. 1949-1965
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Journal article (peer-reviewed)
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| 6. |
- Asano, H., et al.
(author)
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Spectroscopic study of the Λ(1405) resonance via the d (K-, n) reaction at J-PARC
- 2019
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In: 13th International Conference on Hypernuclear and Strange Particle Physics, HYP 2018. - : AIP Publishing. - 9780735418721 ; 2130
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Conference paper (peer-reviewed)abstract
- The structure of the Λ(1405) hyperon is an important and long-standing issue related to the K̄-nucleus interaction. The J-PARC E31 experiment has been performed to investigate the Λ(1405) spectrum shape. Because it is hard to form the Λ(1405) directly by a K̄N scattering in free space, E31 uses the d(K-, n) reaction with an incident kaon momentum of 1 GeV/c. We will identify three final states - ς-π+, ς+π-, ς0π0-so that the isospin structure of hyperon resonance states produced can be decomposed. The first physics run of the E31 experiment was performed in 2016. To enhance the statistics of the data set, we have performed the second physics run in the beginning of 2018. During the second run of E31, around 3.9×1010 kaons impacted on the deuteron target.
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| 7. |
- Beal, Jacob, et al.
(author)
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Robust estimation of bacterial cell count from optical density
- 2020
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In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Journal article (peer-reviewed)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 8. |
- Yamaga, Takumi, et al.
(author)
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Study of the elementary (K -, n) reactions to search for the K NN bound state via the 3He (K -, n) reaction at J-PARC
- 2016
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In: XVIth International Conference on Hadron Spectroscopy, Hadron 2015. - : Author(s). - 9780735413894 ; 1735
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Conference paper (peer-reviewed)abstract
- We have searched for the simplest kaonic nuclear state, K̄NN, using the in-flight 3He (K-, n) reaction at the J-PARC hadron experimental facility. In the semi-inclusive neutron missing-mass spectrum at θnlab=0°, an excess of yield was observed just below the K- pp mass-threshold, which cannot be explained by any elementary reactions [PTEP 2015, 061D01]. To understand the missing-mass spectrum of 3He (K-, n) X, we investigated the elementary (K-, n) reactions using hydrogen and deuterium targets. The p (K-, n) X missing-mass spectrum was well described by the charge-exchange reaction. However, in the d (K-, n) X spectrum, we observed an excess of yield just below the K- p mass-threshold, which was similar to that in the 3He (K-, n) X spectrum.
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| 9. |
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| 10. |
- Sada, Y., et al.
(author)
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Structure near the K- + p + p threshold in the in-flight 3He(K-, Λp)n reaction
- 2016
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In: Progress of Theoretical and Experimental Physics. - : Oxford University Press (OUP). - 2050-3911. ; 2016:5
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Journal article (peer-reviewed)abstract
- To search for an S = -1 di-baryonic state which decays toΛp, the 3He(K-,Λp)nmissing reaction was studied at 1.0 GeV/c. Unobserved neutrons were kinematically identified from the missing mass MX of the 3He (K-,Λp) X reaction in order to have a large acceptance for the Λpn final state. The observed Λpn events, distributed widely over the kinematically allowed region of the Dalitz plot, establish that the major component comes from a three-nucleon absorption process. A concentration of events at a specific neutron kinetic energy was observed in a region of low momentum transfer to the Λp. To account for the observed peak structure, the simplest S-wave polewas assumed to exist in the reaction channel, having a Breit-Wigner formin energy and with a Gaussian form factor. A minimum X2 method was applied to deduce its mass, MX = 2355+6 -8 (stat.) ±12 (syst.)MeV/c2, and decay width, γX = 110+19 -17 (stat.) ±27 (syst.)MeV/c2, respectively. The form factor parameter QX ∼ 400MeV/c implies that the range of the interaction is about 0.5 fm.
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| 11. |
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| 12. |
- Apers, Silke, et al.
(author)
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Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease - International Study (APPROACH-IS) : Rationale, design, and methods
- 2015
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 179, s. 334-342
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Journal article (peer-reviewed)abstract
- Background: Data on patient-reported outcomes (PROs) in adults with congenital heart disease (CHD) are inconsistent and vary across the world. Better understanding of PROs and their differences across cultural and geographic barriers can best be accomplished via international studies using uniform research methods. The APPROACH-IS consortium (Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease - International Study) was created for this purpose and investigates PROs in adults with CHD worldwide. This paper outlines the project rationale, design, and methods. Methods/design: APPROACH-IS is a cross-sectional study. The goal is to recruit 3500-4000 adults with CHD from 15 countries in five major regions of the world (Asia, Australia, Europe, North and South America). Self-report questionnaires are administered to capture information on PRO domains: (i) perceived health status (12-item Short-form Health Survey & EuroQOL-5D); (ii) psychological functioning (Hospital Anxiety and Depression Scale); (iii) health behaviors (Health-Behavior Scale-Congenital Heart Disease); and (iv) quality of life (Linear Analog Scale & Satisfaction With Life Scale). Additionally, potential explanatory variables are assessed: (i) socio-demographic variables; (ii) medical history (chart review); (iii) sense of coherence (Orientation to Life Questionnaire); and (iv) illness perceptions (Brief Illness Perception Questionnaire). Descriptive analyses and multilevel models will examine differences in PROs and investigate potential explanatory variables. Discussion: APPROACH-IS represents a global effort to increase research understanding and capacity in the field of CHD, and will have major implications for patient care. Results will generate valuable information for developing interventions to optimize patients' health and well-being.
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| 13. |
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| 14. |
- Callus, Edward, et al.
(author)
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Phenotypes of adults with congenital heart disease around the globe : a cluster analysis.
- 2021
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In: Health and Quality of Life Outcomes. - : Springer Science and Business Media LLC. - 1477-7525. ; 19:1
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To derive cluster analysis-based groupings for adults with congenital heart disease (ACHD) when it comes to perceived health, psychological functioning, health behaviours and quality of life (QoL).METHODS: This study was part of a larger worldwide multicentre study called APPROACH-IS; a cross sectional study which recruited 4028 patients (2013-2015) from 15 participating countries. A hierarchical cluster analysis was performed using Ward's method in order to group patients with similar psychological characteristics, which were defined by taking into consideration the scores of the following tests: Sense Of Coherence, Health Behavior Scale (physical exercise score), Hospital Anxiety Depression Scale, Illness Perception Questionnaire, Satisfaction with Life Scale and the Visual Analogue Scale scores of the EQ-5D perceived health scale and a linear analogue scale (0-100) measuring QoL.RESULTS: 3768 patients with complete data were divided into 3 clusters. The first and second clusters represented 89.6% of patients in the analysis who reported a good health perception, QoL, psychological functioning and the greatest amount of exercise. Patients in the third cluster reported substantially lower scores in all PROs. This cluster was characterised by a significantly higher proportion of females, a higher average age the lowest education level, more complex forms of congenital heart disease and more medical comorbidities.CONCLUSIONS: This study suggests that certain demographic and clinical characteristics may be linked to less favourable health perception, quality of life, psychological functioning, and health behaviours in ACHD. This information may be used to improve psychosocial screening and the timely provision of psychosocial care.
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| 15. |
- Einarsdottir, E., et al.
(author)
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CELSR2 is a candidate susceptibility gene in idiopathic scoliosis
- 2017
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:12
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Journal article (peer-reviewed)abstract
- A Swedish pedigree with an autosomal dominant inheritance of idiopathic scoliosis was initially studied by genetic linkage analysis, prioritising genomic regions for further analysis. This revealed a locus on chromosome 1 with a putative risk haplotype shared by all affected individuals. Two affected individuals were subsequently exome-sequenced, identifying a rare, non-synonymous variant in the CELSR2 gene. This variant is rs141489111, a c. G6859A change in exon 21 (NM_001408), leading to a predicted p. V2287I (NP_001399.1) change. This variant was found in all affected members of the pedigree, but showed reduced penetrance. Analysis of tagging variants in CELSR1-3 in a set of 1739 Swedish-Danish scoliosis cases and 1812 controls revealed significant association (p = 0.0001) to rs2281894, a common synonymous variant in CELSR2. This association was not replicated in case-control cohorts from Japan and the US. No association was found to variants in CELSR1 or CELSR3. Our findings suggest a rare variant in CELSR2 as causative for idiopathic scoliosis in a family with dominant segregation and further highlight common variation in CELSR2 in general susceptibility to idiopathic scoliosis in the Swedish-Danish population. Both variants are located in the highly conserved GAIN protein domain, which is necessary for the auto-proteolysis of CELSR2, suggesting its functional importance.
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| 16. |
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| 17. |
- Ko, Jong Mi, et al.
(author)
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Differential impact of physical activity type on depression in adults with congenital heart disease : A multi-center international study
- 2019
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In: Journal of Psychosomatic Research. - : Elsevier BV. - 0022-3999 .- 1879-1360. ; 124
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: This study aimed to examine the association between physical activity (PA) and depression in a large international cohort of adults with congenital heart disease (ACHD) as data about the differential impact of PA type on depression in this population are lacking.METHODS: In 2018, we conducted a cross-sectional assessment of 3908 ACHD recruited from 24 ACHD-specialized centers in 15 countries between April 2013 to March 2015. The Hospital Anxiety and Depression Scale was used to assess self-reported depressive symptoms and the Health-Behavior Scale-Congenital Heart Disease was used to collect PA information. Cochran-Armitage tests were performed to assess trends between depressive symptom levels and PA participation. Chi-Square and Wilcoxon Rank Sum tests were utilized to examine relations between depressive symptom levels and patient characteristics. Stepwise multivariable models were then constructed to understand the independent impact of PA on depressive symptoms.RESULTS: The overall prevalence of elevated depressive symptoms in this sample was 12% with significant differences in rates between countries (p < .001). Physically active individuals were less likely to be depressed than those who were sedentary. Of the 2 PA domains examined, sport participation rather than active commute was significantly associated with reduced symptoms of depression. After adjustment in multivariable analysis, sport participation was still significantly associated with 38% decreased probability of depressive symptoms (p < .001).CONCLUSIONS: Sport participation is independently associated with reduced depressive symptoms. The development and promotion of sport-related exercise prescriptions uniquely designed for ACHD may improve depression status in this unique population.
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| 18. |
- Ko, Jong Mi, et al.
(author)
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Physical Activity-Related Drivers of Perceived Health Status in Adults With Congenital Heart Disease
- 2018
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In: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 122:8, s. 1437-1442
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Journal article (peer-reviewed)abstract
- Data on the differential impact of physical activity on perceived health status (PHS) in a large adult congenital heart disease (ACHD) patient population are lacking. We conducted a cross-sectional assessment of 4,028 ACHD patients recruited from 24 ACHD-specialized centers in 15 countries across 5 continents to examine the association between physical activity and PHS in a large international cohort of ACHD patients. A linear analog scale of the EuroQol-5D 3 level version and the 12-item Short Form Health Survey-version 2 were used to assess self-reported health status and the Health-Behavior Scale-Congenital Heart Disease was used as a subjective measurement of physical activity type, participation, and level. Correlation analyses and Wilcoxon Rank Sum tests examined bivariate relations between sample characteristics and PHS scores. Then, multivariable models were constructed to understand the impact of physical activity on PHS. Only 30% of our sample achieved recommended physical activity levels. Physically active patients reported better PHS than sedentary patients; however, the amount of physical activity was not associated with PHS. Further statistical analyses demonstrated that specifically sport participation regardless of physical activity level was a predictor of PHS. In conclusion, the majority of ACHD patients across the world are physically inactive. Sport participation appears to be the primary physical activity-related driver of PHS. By promoting sport-related exercise ACHD specialists thus may improve PHS in ACHD patients.
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| 19. |
- Kou, Dan, et al.
(author)
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Peatland Heterogeneity Impacts on Regional Carbon Flux and Its Radiative Effect Within a Boreal Landscape
- 2022
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In: Journal of Geophysical Research: Biogeosciences. - 2169-8953. ; 127:9
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Journal article (peer-reviewed)abstract
- Peatlands, with high spatial variability in ecotypes and microforms, constitute a significant part of the boreal landscape and play an important role in the global carbon (C) cycle. However, the effects of this peatland heterogeneity within the boreal landscape are rarely quantified. Here, we use field-based measurements, high-resolution land cover classification, and biogeochemical and atmospheric models to estimate the atmosphere-ecosystem C fluxes and the corresponding radiative effect (RE) for a boreal landscape (Kaamanen) in northern Finland. Our result shows that the Kaamanen catchment currently functioned as a sink of carbon dioxide (CO2) and a source of methane (CH4). Peatlands (26% of the area) contributed 22% of the total CO2 uptake and 89% of CH4 emissions; forests (61%) accounted for 78% of CO2 uptake and offset 6% of CH4 emissions; water bodies (13%) offset 7% of CO2 uptake and contributed 11% of CH4 emissions. The heterogeneity of peatlands accounted for 11%, 88%, and 75% of the area-weighted variability (deviation from the area-weighted mean among different land cover types (LCTs) within the catchment) in CO2 flux, CH4 flux, and the combined RE of CO2 and CH4 exchanges over the 25-year time horizon, respectively. Aggregating peatland LCTs or misclassifying them as nonpeatland LCTs can significantly (p < 0.05) bias the regional CH4 exchange and RE estimates, while differentiating between drier noninundated and wetter inundated peatlands can effectively reduce the bias. Current land cover products lack such details in peatland heterogeneity, which would be needed to better constrain boreal C budgets and global C-climate feedbacks.
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| 20. |
- Kou, R. H., et al.
(author)
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Charge transfer-tuned magnetism in Nd-substituted Gd5Si4
- 2018
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In: AIP Advances. - : AIP Publishing. - 2158-3226. ; 8:12
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Journal article (peer-reviewed)abstract
- We report a charge-transfer mechanism in tuning of magnetism of Nd-substituted Gd5-xNdxSi4 (x=1 and 2.5) compounds. The X-ray absorption near edge structure measurements demonstrated that Nd substitutions for Gd induce charge transfer of 5d electrons from Gd to Nd. The charge transfer weakens spin-orbital coupling of Gd but strengthens that of Nd. Consequently, the magnetization responses of the substituted compounds to low magnetic fields are increased while their saturation magnetization is reduced. Electronic structure calculations showed that the charge transfer stabilizes a ferromagnetic and a ferrimagnetic structure in the compounds with x = 1 and 2.5, respectively, but that it does not change the 5d-3p hybridization significantly. It is suggested that the charge transfer of 5d electrons may occur in other rare earth-substituted Gd5Si4 compounds allowing for tuning of their magnetism.
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| 21. |
- Kou, Shao Quan, et al.
(author)
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Numerical investigation of particle breakage as applied to mechanical crushing—Part II: Interparticle breakage
- 2001
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In: International Journal of Rock Mechanics And Mining Sciences. - 1365-1609 .- 1873-4545. ; 38:8, s. 1163-1172
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Journal article (peer-reviewed)abstract
- A numerical approach to interparticle breakage is applied using the rock failure process analysis code, RFPA2D. A 2D particle assembly in a container is first numerically simulated to obtain the fringe patterns of stress fields that resemble the photoelastic test. Then, in addition, the interparticle breakage of the particle assembly in a chamber is conducted. The chamber consists of a steel container and a steel platen for transferring the load, and contains 15 particles of arbitrary sizes and irregular shapes. A plane strain condition is assumed. The particle bed is loaded under form conditions, in which the size reduction and the applied force are a function of the displacement. The numerical results indicate that, during the crushing process, three principal regimes appear: (i) the elastic deformation regime, where each particle deforms elastically; (ii) the fragmentation regime, where the particle assembly is crushed in a particle-by-particle fashion; and (iii) the assembly hardening regime, where the densified assembly recovers a significant stiffness. The dominant mode of failure is at first splitting, which is more or less parallel to the loading direction, and then progressive crushing, which mainly depends on the confinement from the chamber walls. The analysis of the load–displacement curves of the assembly obtained from the simulations reveals a high undulating load plateau, which suggests a macro-ductile behaviour.
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| 22. |
- Kou, Shao Quan, et al.
(author)
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Numerical simulation of the cutting of inhomogeneous rocks
- 1999
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In: International Journal of Rock Mechanics And Mining Sciences. - 1365-1609 .- 1873-4545. ; 36:5, s. 711-717
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Journal article (peer-reviewed)abstract
- In this study, the possible modes of crack initiation and propagation leading to chip formation in rock cutting are studied numerically by using a rock failure process analysis code referred to as RFPA. By using this approach, additional information is obtained on the tool-rock interaction and the failure mechanisms of rock under mechanical tools.
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| 23. |
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| 24. |
- Kou, Shaoquan, et al.
(author)
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Rock fragmentation mechanisms induced by a drill bit
- 2004
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In: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 41:Suppl. 1, s. 527-532
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Journal article (peer-reviewed)abstract
- In most of the mechanical excavation methods the fundamental process is indentation of the rock by a bit. The present paper focuses on discussing how the rock is fragmented under the action of a drill bit. The discussions are mainly based on numerical modelling using the rock and tool interaction code (R-T2D) and taking rock heterogeneity into consideration. The simulated results concerning rock penetrations with one, two and multiple indenters are, however, compared with experiments available from the literature. The emphasis is put on discussion of the formation of side-cracks and crushed zones that constitute the major rock removal fractures. The agreement between numerical simulation and experimental observations are reasonably good. This reveals the mechanisms of crack initiation, propagation and coalescence induced by the action of button bits to form the rock fragmentation in a drilling process. The investigation can contribute not only to improving percussive drilling but also to understanding other rock fragmentation and comminution methods and equipment since indentation is also the fundamental process for them.
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| 25. |
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| 26. |
- Larsson, Lena, et al.
(author)
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Geographical variation and predictors of physical activity level in adults with congenital heart disease
- 2019
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In: International Journal of Cardiology : Heart & Vasculature. - : Elsevier. - 2352-9067. ; 22, s. 20-25
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Journal article (peer-reviewed)abstract
- Physical activity is important to maintain and promote health. This is of particular interest in patients with congenital heart disease(CHD) where acquired heart disease should be prevented. The World Health Organization (WHO) recommends a minimum of 2.5 h/week of physical activity exceeding 3 metabolic equivalents (METS) to achieve positive health effects. It is unknown whether physical activity levels (PAL) in adult CHD patients differ by country of origin.Methods3896 adults with CHD recruited from 15 countries over 5 continents completed self-reported instruments, including the Health Behaviour Scale (HBS-CHD), within the APPROACH-IS project. For each patient, we calculated whether WHO recommendations were achieved or not. Associated factors were investigated using Generalized Linear Mixed Models.ResultsOn average, 31% reached the WHO recommendations but with a great variation between geographical areas (India: 10%–Norway: 53%). Predictors for physical activity level in line with the WHO recommendations, with country of residence as random effect, were male sex (OR 1.78, 95%CI 1.52–2.08), NYHA-class I (OR 3.10, 95%CI 1.71–5.62) and less complex disease (OR 1.46, 95%CI 1.16–1.83). In contrast, older age (OR 0.97, 95%CI 0.96–0.98), lower educational level (OR 0.41, 95%CI 0.26–0.64) and being unemployed (OR 0.57, 95%CI 0.42–0.77) were negatively associated with reaching WHO recommendations.ConclusionsA significant proportion of patients with CHD did not reach the WHO physical activity recommendations. There was a large variation in physical activity level by country of origin. Based on identified predictors, vulnerable patients may be identified and offered specific behavioral interventions.
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| 27. |
- Leibold, Allison, et al.
(author)
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Pain in adults with congenital heart disease : An international perspective
- 2021
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In: International Journal of Cardiology Congenital Heart Disease. - : Elsevier. - 2666-6685. ; 5
-
Journal article (peer-reviewed)abstract
- Background: Patients with adult congenital heart disease (ACHD) have many risk factors for chronic pain such as prior cardiac interventions and adult comorbidities. However, the prevalence of chronic pain has not been well described in this population. We sought to determine the prevalence of pain in a large international cohort of patients with ACHD.Methods: Data from the APPROACH-IS dataset was utilized for this study which includes 4028 patients with ACHD from 15 different countries. The prevalence of pain was assessed under the health status patient reported outcome domain utilizing the EuroQol-5D 3 level version tool. Multivariable logistic regression was used to assess differences across countries in pain, taking into account country-level random effects for clustering across observations within each country.Results: A total of 3832 patients with ACHD met the study criteria, median age 32 years [IQR 25, 42], 52.6% females. The prevalence of at least moderate pain was reported by 28.9% (95% CO 27.5 = 30.3%) of participants. Pain was associated with country of origin, age, gender, background, education and marital status as well as several clinical variables including disease complexity, cardiac device presence, history of heart failure, psychiatric conditions and presence of other medical conditions. Those with pain had lower levels of perceived health and a lower quality of life score.Conclusion: Pain in patients with ACHD is common, impacting nearly one-third of patients. Given the far reaching implications of pain in patients with ACHD, further study of pain characteristics and treatment management appear warranted.
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| 28. |
- Liu, Hongyuan, et al.
(author)
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Numerical simulation of shear fracture (mode II) in heterogeneous brittle rock
- 2004
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In: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 41:Suppl. 1, s. 14-19
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Journal article (peer-reviewed)abstract
- The fracture process of a heterogeneous brittle rock in the shear-box test is numerically investigated by means of the rock and tool interaction code (R-T2D). On the basis of the simulated results, the mode II fracture toughness is calculated, which is KIIC =7.72MPa root m, and the influence of heterogeneity and confinement on the formation and characteristics of shear fracture is discussed. It is found that with the confinement increasing, the fracture mechanisms in the shear-box test of heterogeneous brittle rock change from mixed tensile and shear failure but are dominated with tensile failure to dominant shear failure. It is concluded that the shear-box test under a confined condition is favourable for creating a condition for mode II fracture and a suitable method for measuring the mode II fracture toughness.
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| 29. |
- Liu, Hongyuan, et al.
(author)
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Numerical simulation of the rock fragmentation process induced by indenters
- 2002
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In: International Journal of Rock Mechanics And Mining Sciences. - 1365-1609 .- 1873-4545. ; 39:4, s. 491-505
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Journal article (peer-reviewed)abstract
- Rock fragmentation processes induced by single and double indenters were examined by a numerical method. The simulated results reproduce the progressive process of rock fragmentation in indentation. Rock deforms elastically at the initial loading stage. Then tensile cracks are initiated around the two corners of the truncated indenter and propagate in the well-known conical Hertzian manner. The rocks immediately under the indenter are in a highly tri-axial stress state, and some of them fail in the ductile cataclastic mode with the stress satisfying the ductile failure surface of the double elliptic strength criterion. With the tensile cone cracks and ductile cataclastic failure releasing the confining pressure, the rocks under the indenter are compressed into failure and the crushed zone gradually comes into being. With increasing loading displacement, the re-compaction behaviour of the crushed zone occurs. Side cracks initiated from the crushed zone or bifurcated from cone cracks are driven by tensile stress associated with the crushed zone to propagate in a curvilinear path and finally intersect with the free surface to form chips. It is pointed out that the curvilinear path is caused by heterogeneity. The simulated force-penetration curve is in fact the indication of the propagation of cracks, the crushing of microstructural grains and the formation of chips. It is found that the confining pressure has an important influence on the indentation results. With decreasing confining pressure, there is a decrease in the indentation strength and a change in the rock failure process from the formation of rock chips to a vertically axially splitting failure. The simulated fragmentation process in the double indenter test reproduces the side cracks, which are induced by two indenters, propagate, interact and finally coalesce, chipping the rock between the indenters. The line spacing is an important factor that affects the fragmentation efficiency in multiple indenter tests. It is pointed out that simultaneous loading with multiple indenters with an appropriate line spacing seems to provide a possibility of forming larger rock chips, controlling the direction of subsurface cracks and consuming a minimum total specific energy. According to the simulated results, it is believed that the numerical simulation method will contribute to an improved knowledge of rock fragmentation in indentation, which will in turn help to enhance mining and drilling efficiency through the improved design of mining tools and equipment.
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| 30. |
- Liu, H. Y., et al.
(author)
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Numerical modelling of the heterogeneous rock fracture process using various test techniques
- 2007
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In: Rock Mechanics and Rock Engineering. - : Springer Science and Business Media LLC. - 0723-2632 .- 1434-453X. ; 40:2, s. 107-144
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Journal article (peer-reviewed)abstract
- A series of numerical tests including both rock mechanics and fracture mechanics tests are conducted by the rock and tool (R-T2D) interaction code coupled with a heterogeneous masterial model to obtain the physical-mechanical properties and fracture toughness, as well as to simulate the crack initiation and propagation, and the fracture progressive process. The simulated results not only predict relatively accurate physical-mechanical parameters and fracture toughness, but also visually reproduce the fracture progressive process compared with the experimental and theoretical results. The detailed stress distribution and redistribution, crack nucleation and initiation, stable and unstable crack propagation, interaction and coalescence, and corresponding load-displacement curves can be proposed as benchmarks for experimental study and theoretical research on crack propagation. It is concluded that the heterogeneous material model is reasonable and the R-T2D code is stable, repeatable and a valuable numerical tool for research on the rock fracture process.
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| 31. |
- Liu, H.Y., et al.
(author)
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Numerical studies on the failure process and associated microseismicity in rock under triaxial compression
- 2004
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In: Tectonophysics. - : Elsevier BV. - 0040-1951 .- 1879-3266. ; 384:1-4, s. 149-174
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Journal article (peer-reviewed)abstract
- In this paper, firstly the mesoscopic elemental mechanical model for elastic damage is developed and implemented into the rock and tool interaction code (R-T (super 2D) ). Then the failure processes of a heterogeneous rock specimen subjected to a wide variety of confining pressures (0-80 MPa) are numerically investigated using the R-T (super 2D) code. According to the simulated results, on the one hand, the numerical simulation reproduced some of the well-known phenomena observed by previous researchers in triaxial tests. Under uniaxial compression, rock failure is caused by a combination of axial splitting and shearing. Dilatancy and a post-failure stage with a descending load bearing capacity are the prominent characteristics of the failure. As the confining pressure increases, the extension of the failed sites is suppressed, but the individual failure sites become dense and link with each other to form a shear fracture plane. Correspondingly, the peak strength, the residual strength and the shear fracture plane angle increase, but the brittleness decreases. When the confining pressure is high enough, the specimen behaves in a plastic manner and a narrow shear fracture plane leads to its failure. The prominent characteristics are volume condensation, ductile cataclastic failure, and a constant load bearing capacity with increasing strain. On the other hand, the numerical simulation revealed some new phenomena. The highest microseismicity events occur in the post-failure stage instead of the maximal stress, and most of the microseismicity energies are released in the failure localization process. As the confining pressure increases, the microseismicity events in the non-linear deformation stage increase dramatically and the ratio between the energies dissipated at the non-linear deformation stage and those dissipated in the whole loading process increases correspondingly. Therefore, it is concluded that the developed mesoscopic elemental mechanical model for elastic damage is able to reproduce accurately the failure characteristics in loading rock specimens under triaxial conditions, and the numerical modelling can furthermore obtain some new clarifications of the rock fracture process.
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| 32. |
- Lu, Chun-Wei, et al.
(author)
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Heart Failure and Patient-Reported Outcomes in Adults With Congenital Heart Disease from 15 Countries
- 2022
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In: Journal of the American Heart Association. - : American Heart Association. - 2047-9980. ; 11:9
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Journal article (peer-reviewed)abstract
- Background: Heart failure (HF) is the leading cause of mortality and associated with significant morbidity in adults with congenital heart disease. We sought to assess the association between HF and patient-report outcomes in adults with congenital heart disease.Methods and Results: As part of the APPROACH-IS (Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease-International Study), we collected data on HF status and patient-reported outcomes in 3959 patients from 15 countries across 5 continents. Patient-report outcomes were: perceived health status (12-item Short Form Health Survey), quality of life (Linear Analogue Scale and Satisfaction with Life Scale), sense of coherence-13, psychological distress (Hospital Anxiety and Depression Scale), and illness perception (Brief Illness Perception Questionnaire). In this sample, 137 (3.5%) had HF at the time of investigation, 298 (7.5%) had a history of HF, and 3524 (89.0%) had no current or past episode of HF. Patients with current or past HF were older and had a higher prevalence of complex congenital heart disease, arrhythmias, implantable cardioverter-defibrillators, other clinical comorbidities, and mood disorders than those who never had HF. Patients with HF had worse physical functioning, mental functioning, quality of life, satisfaction with life, sense of coherence, depressive symptoms, and illness perception scores. Magnitudes of differences were large for physical functioning and illness perception and moderate for mental functioning, quality of life, and depressive symptoms.Conclusions: HF in adults with congenital heart disease is associated with poorer patient-reported outcomes, with large effect sizes for physical functioning and illness perception.
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| 33. |
- Moons, Philip, 1968, et al.
(author)
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Patient-Reported Outcomes in Adults With Congenital Heart Disease Following Hospitalization (from APPROACH-IS).
- 2021
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In: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 145, s. 135-142
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Journal article (peer-reviewed)abstract
- In this international study, we (1) compared patient-reported outcomes (PROs) in adults with congenital heart disease (CHD) who had versus had not been hospitalized during the previous 12 month, (2) contrasted PROs in patients who had been hospitalized for cardiac surgery versus nonsurgical reasons, (3) assessed the magnitude of differences between the groups (i.e., effect sizes), and (4) explored differential effect sizes between countries. APPROACH-IS was a cross-sectional, observational study that enrolled 4,028 patients from 15 countries (median age 32 years; 53% females). Self-report questionnaires were administered to measure PROs: health status; anxiety and depression; and quality of life. Overall, 668 patients (17%) had been hospitalized in the previous 12 months. These patients reported poorer outcomes on all PROs, with the exception of anxiety. Patients who underwent cardiac surgery demonstrated a better quality of life compared with those who were hospitalized for nonsurgical reasons. For significant differences, the effect sizes were small, whereas they were negligible in nonsignificant comparisons. Substantial intercountry differences were observed. For various PROs, moderate to large effect sizes were found comparing different countries. In conclusion, adults with CHD who had undergone hospitalization in the previous year had poorer PROs than those who were medically stable. Researchers ought to account for the timing of recruitment when conducting PRO research as hospitalization can impact results.
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| 34. |
- Moons, Philip, 1968, et al.
(author)
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Sense of coherence in adults with congenital heart disease in 15 countries : patient characteristics, cultural dimensions and quality of life
- 2021
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In: European Journal of Cardiovascular Nursing. - : Oxford University Press. - 1474-5151 .- 1873-1953. ; 20:1, s. 48-55
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Journal article (peer-reviewed)abstract
- Background: Previous studies have found that sense of coherence (SOC) is positively related to quality of life (QoL) in persons with chronic conditions. In congenital heart disease (CHD), the evidence is scant.Aims: We investigated (i) intercountry variation in SOC in a large international sample of adults with CHD; (ii) the relationship between demographic and clinical characteristics and SOC; (iii) the relationship between cultural dimensions of countries and SOC; and (iv) variation in relative importance of SOC in explaining QoL across the countries.Methods: APPROACH-IS was a cross-sectional, observational study, with 4028 patients from 15 countries enrolled. SOC was measured using the 13-item SOC scale (range 13–91) and QoL was assessed by a linear analog scale (range 0–100).Results: The mean SOC score was 65.5±13.2. Large intercountry variation was observed with the strongest SOC in Switzerland (68.8±11.1) and the lowest SOC in Japan (59.9±14.5). A lower SOC was associated with a younger age; lower educational level; with job seeking, being unemployed or disabled; unmarried, divorced or widowed; from a worse functional class; and simple CHD. Power distance index and individualism vs collectivism were cultural dimensions significantly related to SOC. SOC was positively associated with QoL in all participating countries and in the total sample, with an explained variance ranging from 5.8% in Argentina to 30.4% in Japan.Conclusion: In adults with CHD, SOC is positively associated with QoL. The implementation of SOC-enhancing interventions might improve QoL, but strategies would likely differ across countries given the substantial variation in explained variance.
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| 35. |
- Rassart, Jessica, et al.
(author)
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Illness perceptions in adult congenital heart disease : A multi-center international study.
- 2017
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 244, s. 130-138
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Journal article (peer-reviewed)abstract
- BACKGROUND: Illness perceptions are cognitive frameworks that patients construct to make sense of their illness. Although the importance of these perceptions has been demonstrated in other chronic illness populations, few studies have focused on the illness perceptions of adults with congenital heart disease (CHD). This study examined (1) inter-country variation in illness perceptions, (2) associations between patient characteristics and illness perceptions, and (3) associations between illness perceptions and patient-reported outcomes.METHODS: Our sample, taken from APPROACH-IS, consisted of 3258 adults with CHD from 15 different countries. Patients completed questionnaires on illness perceptions and patient-reported outcomes (i.e., quality of life, perceived health status, and symptoms of depression and anxiety). Patient characteristics included sex, age, marital status, educational level, employment status, CHD complexity, functional class, and ethnicity. Linear mixed models were applied.RESULTS: The inter-country variation in illness perceptions was generally small, yet patients from different countries differed in the extent to which they perceived their illness as chronic and worried about their illness. Patient characteristics that were linked to illness perceptions were sex, age, employment status, CHD complexity, functional class, and ethnicity. Higher scores on consequences, identity, and emotional representation, as well as lower scores on illness coherence and personal and treatment control, were associated with poorer patient-reported outcomes.CONCLUSIONS: This study emphasizes that, in order to gain a deeper understanding of patients' functioning, health-care providers should focus not only on objective indicators of illness severity such as the complexity of the heart defect, but also on subjective illness experiences.
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| 36. |
- Tang, C.A., et al.
(author)
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Crack propagation and coalescence in brittle materials under compression
- 1998
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In: Engineering Fracture Mechanics. - 0013-7944 .- 1873-7315. ; 61:3-4, s. 311-324
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Journal article (peer-reviewed)abstract
- Two particular cases concerning crack propagation and coalescence in brittle materials have been modeled by using the rock failure process analysis code, RFPA2D, and the results have been validated by reported experimental observations. Firstly, axial compression of numerical samples containing a number of large, pre-existing flaws and a row of suitably oriented smaller flaws are simulated. It has been confirmed that under axial compression, wing-cracks nucleate at the tips of the pre-existing flaws, grow with increasing compression, and become parallel to the direction of the maximum far-field compression. However, coalescence of the wing-cracks may be in either tensile mode or shear mode, or a combination of both modes. The numerical results show qualitatively a reasonably good agreement with reported experimental observations for samples with similar flaw arrangements. The numerical results demonstrate that, with a confining pressure, the crack growth is stable and stops at some finite crack length; whereas a lateral tensile stress even with a small value will result in an unstable crack growth after a certain crack length is attained. Secondly, failure mode in a sample containing inhomogeneities on grain scale has also been simulated. The results show that the failure mode strongly depends on the mechanical and geometric properties of the grains and inclusions
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| 37. |
- Tang, C A, et al.
(author)
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Fracture spacing in layered materials and pattern transition from parallel to polygonal fractures
- 2006
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In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics. - 1539-3755 .- 1550-2376. ; 73:5, s. 056120-28
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Journal article (peer-reviewed)abstract
- We perform three-dimensional simulations of fracture growth in a three-layered plate model with an embedded heterogeneous layer under horizontal biaxial stretch (representing stretch from directional to isotropic) by the finite element approach. The fractures develop under a quasistatical, slowly increasing biaxial strain. The material inhomogeneities are accounted for by assigning each element a failure threshold that is defined by a given statistical distribution. A universal scale law of fracture spacing to biaxial strain in terms of principal stress ratio is well demonstrated in a three-dimensional fashion. The numerically obtained fracture patterns show a continuous pattern transition from parallel fractures, laddering fracture to polygonal fractures, which depends strongly on the far-field loading conditions in terms of principal stress ratio ......
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| 38. |
- Tang, C. A., et al.
(author)
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Numerical investigation of particle breakage as applied to mechanical crushing—Part I: Single-particle breakage
- 2001
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In: International Journal of Rock Mechanics And Mining Sciences. - 1365-1609 .- 1873-4545. ; 38:8, s. 1147-1162
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Journal article (peer-reviewed)abstract
- A numerical approach to particle breakage is applied using the Rock Failure Process Analysis code, RFPA (super 2D) . The numerical tool is validated by simulating the Brazilian test with a two-dimensional disk sample. Then two irregularly shaped particles with an exact geometry and exact mechanical properties are numerically modelled to investigate their breakage behaviour under unconfined and confined loading conditions. The numerical results indicate that the dominant mode of failure is catastrophic splitting and progressive crushing, which mainly depends on the loading conditions with respect to confinement. The analysis of the load-displacement curves obtained from the simulations suggests a brittle-ductile transition between the two cases. The lateral constraint increases the initial stiffness and the maximum breakage strength of the particle. Most of the energy released during the failure process comes from the crushing of highly stressed areas, particularly, in the vicinity of the contact points where a crushed zone forms. It is also found that the particle shape governs the breakage strength in addition to the material properties themselves, and that the heterogeneity of the particles governs the fracture propagation paths
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| 39. |
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| 40. |
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| 41. |
- Treat, Claire C., et al.
(author)
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Permafrost Carbon : Progress on Understanding Stocks and Fluxes Across Northern Terrestrial Ecosystems
- 2024
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In: Journal of Geophysical Research - Biogeosciences. - : American Geophysical Union (AGU). - 2169-8953 .- 2169-8961. ; 129:3
-
Journal article (peer-reviewed)abstract
- Significant progress in permafrost carbon science made over the past decades include the identification of vast permafrost carbon stocks, the development of new pan-Arctic permafrost maps, an increase in terrestrial measurement sites for CO2 and methane fluxes, and important factors affecting carbon cycling, including vegetation changes, periods of soil freezing and thawing, wildfire, and other disturbance events. Process-based modeling studies now include key elements of permafrost carbon cycling and advances in statistical modeling and inverse modeling enhance understanding of permafrost region C budgets. By combining existing data syntheses and model outputs, the permafrost region is likely a wetland methane source and small terrestrial ecosystem CO2 sink with lower net CO2 uptake toward higher latitudes, excluding wildfire emissions. For 2002–2014, the strongest CO2 sink was located in western Canada (median: −52 g C m−2 y−1) and smallest sinks in Alaska, Canadian tundra, and Siberian tundra (medians: −5 to −9 g C m−2 y−1). Eurasian regions had the largest median wetland methane fluxes (16–18 g CH4 m−2 y−1). Quantifying the regional scale carbon balance remains challenging because of high spatial and temporal variability and relatively low density of observations. More accurate permafrost region carbon fluxes require: (a) the development of better maps characterizing wetlands and dynamics of vegetation and disturbances, including abrupt permafrost thaw; (b) the establishment of new year-round CO2 and methane flux sites in underrepresented areas; and (c) improved models that better represent important permafrost carbon cycle dynamics, including non-growing season emissions and disturbance effects.
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| 42. |
- Van Doesum, Niels J., et al.
(author)
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Social mindfulness and prosociality vary across the globe
- 2021
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 118:35
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Journal article (peer-reviewed)abstract
- Humans are social animals, but not everyone will be mindful of others to the same extent. Individual differences have been found, but would social mindfulness also be shaped by one's location in the world? Expecting cross-national differences to exist, we examined if and how social mindfulness differs across countries. At little to no material cost, social mindfulness typically entails small acts of attention or kindness. Even though fairly common, such low-cost cooperation has received little empirical attention. Measuring social mindfulness across 31 samples from industrialized countries and regions (n = 8,354), we found considerable variation. Among selected country-level variables, greater social mindfulness was most strongly associated with countries' better general performance on environmental protection. Together, our findings contribute to the literature on prosociality by targeting the kind of everyday cooperation that is more focused on communicating benevolence than on providing material benefits.
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| 43. |
- Wang, ZC, et al.
(author)
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Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd
- 2016
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12846-
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Journal article (peer-reviewed)abstract
- Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we report a crowdsourcing project to annotate and reanalyse a large number of gene expression profiles from Gene Expression Omnibus (GEO). Through a massive open online course on Coursera, over 70 participants from over 25 countries identify and annotate 2,460 single-gene perturbation signatures, 839 disease versus normal signatures, and 906 drug perturbation signatures. All these signatures are unique and are manually validated for quality. Global analysis of these signatures confirms known associations and identifies novel associations between genes, diseases and drugs. The manually curated signatures are used as a training set to develop classifiers for extracting similar signatures from the entire GEO repository. We develop a web portal to serve these signatures for query, download and visualization.
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| 44. |
- Welsh, P., et al.
(author)
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Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study
- 2018
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In: European journal of heart failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 20, s. 268-277
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Journal article (peer-reviewed)abstract
- AIMS: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. METHODS AND RESULTS: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hsTnT)], neurohumoral [mid-regional pro-adrenomedullin (MR-proADM) and copeptin], renal (cystatin C), and inflammatory [high-sensitivity C-reactive protein (hsCRP)] biomarkers were measured at randomization in 1853 participants with complete data. The relationship between these biomarkers and the primary composite endpoint of heart failure hospitalization or cardiovascular death over 28 months of follow-up (n = 834) was evaluated using Cox proportional hazards regression, the c-statistic and the net reclassification index (NRI). After adjustment, the hazard ratio (HR) for the composite outcome in the top tertile of the distribution compared to the lowest tertile for each biomarker was: NT-proBNP 3.96 (95% CI 3.16-4.98), hsTnT 3.09 (95% CI 2.47-3.88), MR-proADM 2.28 (95% CI 1.83-2.84), copeptin 1.66 (95% CI 1.35-2.04), cystatin C 1.92 (95% CI 1.55-2.37), and hsCRP 1.51 (95% CI 1.27-1.80). A basic clinical prediction model was improved on addition of each biomarker individually, most strongly by NT-proBNP (NRI +62.3%, P < 0.001), but thereafter was only improved marginally by addition of hsTnT (NRI +33.1%, P = 0.004). Further addition of biomarkers did not improve discrimination further. Findings were similar for all-cause mortality. CONCLUSION: Once NT-proBNP is included, only hsTnT moderately further improved risk stratification in this group of chronic heart failure with reduced ejection fraction patients with moderate anaemia. NT-proBNP and hsTnT far outperform other emerging biomarkers in prediction of adverse outcome.
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| 45. |
- Zhang, J., et al.
(author)
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Mechanism of periodically distributed fracture in reinforced concrete beam under uniaxial tension
- 2007
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In: Yingyong Lixue Xuebao. - 1000-4939. ; 24:4, s. 646-651
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Journal article (peer-reviewed)abstract
- A numerical code RFPA3D(Three-Dimension Realistic Failure Process Analysis) is employeel to simulate the three-dimensional failure process of reinforced concrete under uniaxial tension. Then the analysis focuses on the stress distribution during the failure process and failure mechanism of the concrete and reinforcement. The numerical tests indicate the periodically distributed fracture in the reinforced concrete structure and the numerical analysis reproduces the complete process of the fracture initiation, infilling and saturation, 3D numerical tests with different thickness of concrete covers reveal that the eritical value of the fracture spacing increases and the crack numbers decreases with increasing ratio of the thickness of the concrete cover to that of the steel bar
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