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Search: WFRF:(Koukel L)

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  • Margolin, S, et al. (author)
  • CYP2D6 and adjuvant tamoxifen: possible differences of outcome in pre- and post-menopausal patients
  • 2013
  • In: Pharmacogenomics. - : Future Medicine Ltd. - 1744-8042 .- 1462-2416. ; 14:6, s. 613-622
  • Journal article (peer-reviewed)abstract
    • Aim: Previous studies on CYP2D6 activity and the effect of adjuvant tamoxifen in breast cancer are inconsistent. We analyzed the impact of the CYP2D6 polymorphism in pre- and post-menopausal patients that were adherent to tamoxifen treatment for at least a year. Materials & methods: A total of 382 breast cancer patients prescribed adjuvant tamoxifen for 5 years constituted the study-base. Clinical information, including compliance and outcome, was retrieved from medical records. Comprehensive CYP2D6 genotyping was performed and translated into predicted metabolic activity. Results & conclusion: In patients adherent to tamoxifen for at least one year (n = 313) there was an association between reduced CYP2D6 activity (≤50% of normal) and recurrence (p = 0.025) and breast cancer-specific mortality (p = 0.034). In a multivariable analysis, CYP2D6 remained an independent predictor of outcome. In a subgroup analysis, the effect of CYP2D6 seemed to derive mainly from premenopausal patients, which represents a new finding that needs validation in a larger study sample. Original submitted 13 November 2012; Revision submitted 1 March 2013
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  • Result 1-4 of 4
Type of publication
conference paper (2)
journal article (2)
Type of content
other academic/artistic (2)
peer-reviewed (2)
Author/Editor
Eliasson, E (4)
Koukel, L (4)
Margolin, S (3)
Dahl, ML (3)
Thorén, L. (3)
Xie, HJ (2)
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Lindh, JD (2)
OSBY, U (1)
Holm, J. (1)
Bertilsson, L (1)
Xie, H (1)
Lindh, J (1)
Mannheimer, B (1)
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University
Karolinska Institutet (4)
Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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