| 1. |
- Callaway, EM, et al.
(author)
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A multimodal cell census and atlas of the mammalian primary motor cortex
- 2021
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
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Journal article (peer-reviewed)abstract
- Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
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| 9. |
- Andersson, Gerhard, et al.
(author)
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Distinguishing levels of tinnitus distress
- 1999
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In: CLINICAL OTOLARYNGOLOGY. - : BLACKWELL SCIENCE LTD. - 0307-7772. ; 24:5, s. 404-410
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Journal article (peer-reviewed)abstract
- Degrees of tinnitus distress were explored in a sample of 216 patients who completed audiological measures and were assessed in a structured interview conducted by a clinical psychologist. The Klockhoff and Lindblom grading system was used and its inter-
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| 10. |
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| 11. |
- Andersson, G, et al.
(author)
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Longitudinal follow-up of tinnitus complaints
- 2001
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In: ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. - : AMER MEDICAL ASSOC. - 0886-4470. ; 127:2, s. 175-179
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Journal article (peer-reviewed)abstract
- Objective: To investigate the long-term outcome of patients with tinnitus, the long-term effects of cognitive behavioral therapy, and what properties of tinnitus predict distress at follow-up. Design: A longitudinal follow-up of a consecutive sample of pa
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| 12. |
- Andersson, G, et al.
(author)
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Social competence and behavioural problems in children with hearing impairment
- 2000
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In: Audiology. - 0020-6091. ; 39:2, s. 88-92
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Journal article (peer-reviewed)abstract
- The focus in this study is on social competence and behavioural problems in a group (n=57) of hearing-impaired 7- to 12-year-old children. Results were related to hearing status, school placement, and gender. Parent and teacher questionnaires were used to
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| 13. |
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| 14. |
- Ferreira, MA, et al.
(author)
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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- 2019
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1741-
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Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
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| 17. |
- Hägnebo, Christina, et al.
(author)
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The influence of vertigo, hearing impairment and tinnitus on the daily life of meniere patients
- 1997
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In: SCANDINAVIAN AUDIOLOGY. - : SCANDINAVIAN UNIVERSITY PRESS. - 0105-0397. ; 26:2, s. 69-76
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Journal article (peer-reviewed)abstract
- The aim of this questionnaire study was to investigate the impact of the symptoms in Meniere's disease on the daily life of patients and to analyse the relationships between the cardinal symptoms and environmental, emotional and activity factors. The stu
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| 26. |
- Thomas, HS, et al.
(author)
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- 2019
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swepub:Mat__t
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| 27. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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