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  • 2021
  • swepub:Mat__t
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  • Aad, G, et al. (author)
  • 2015
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  • Niemi, MEK, et al. (author)
  • 2021
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  • Kanai, M, et al. (author)
  • 2023
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  • Thomas, HS, et al. (author)
  • 2019
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  • 2021
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  • Bravo, L, et al. (author)
  • 2021
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  • Glasbey, JC, et al. (author)
  • 2021
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  • Tabiri, S, et al. (author)
  • 2021
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  • Mishra, A, et al. (author)
  • Diminishing benefits of urban living for children and adolescents' growth and development
  • 2023
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
  • Journal article (peer-reviewed)abstract
    • Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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  • Bulluck, H, et al. (author)
  • Independent Predictors of Cardiac Mortality and Hospitalization for Heart Failure in a Multi-Ethnic Asian ST-segment Elevation Myocardial Infarction Population Treated by Primary Percutaneous Coronary Intervention
  • 2019
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 10072-
  • Journal article (peer-reviewed)abstract
    • We aimed to identify independent predictors of cardiac mortality and hospitalization for heart failure (HHF) from a real-world, multi-ethnic Asian registry [the Singapore Myocardial Infarction Registry] of ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention. 11,546 eligible STEMI patients between 2008 and 2015 were identified. In-hospital, 30-day and 1-year cardiac mortality and 1-year HHF rates were 6.4%, 6.8%, 8.3% and 5.2%, respectively. From the derivation cohort (70% of patients), age, Killip class and cardiac arrest, creatinine, hemoglobin and troponin on admission and left ventricular ejection fraction (LVEF) during hospitalization were predictors of in-hospital, 30-day and 1-year cardiac mortality. Previous ischemic heart disease (IHD) was a predictor of in-hospital and 30-day cardiac mortality only, whereas diabetes was a predictor of 1-year cardiac mortality only. Age, previous IHD and diabetes, Killip class, creatinine, hemoglobin and troponin on admission, symptom-to-balloon-time and LVEF were predictors of 1-year HHF. The c-statistics were 0.921, 0.901, 0.881, 0.869, respectively. Applying these models to the validation cohort (30% of patients) showed good fit and discrimination (c-statistic 0.922, 0.913, 0.903 and 0.855 respectively; misclassification rate 14.0%, 14.7%, 16.2% and 24.0% respectively). These predictors could be incorporated into specific risk scores to stratify reperfused STEMI patients by their risk level for targeted intervention.
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  • Gustavsson, AK, et al. (author)
  • 3D single-molecule super-resolution microscopy with a tilted light sheet
  • 2018
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 123-
  • Journal article (peer-reviewed)abstract
    • Tilted light sheet microscopy with 3D point spread functions (TILT3D) combines a novel, tilted light sheet illumination strategy with long axial range point spread functions (PSFs) for low-background, 3D super-localization of single molecules as well as 3D super-resolution imaging in thick cells. Because the axial positions of the single emitters are encoded in the shape of each single-molecule image rather than in the position or thickness of the light sheet, the light sheet need not be extremely thin. TILT3D is built upon a standard inverted microscope and has minimal custom parts. The result is simple and flexible 3D super-resolution imaging with tens of nm localization precision throughout thick mammalian cells. We validate TILT3D for 3D super-resolution imaging in mammalian cells by imaging mitochondria and the full nuclear lamina using the double-helix PSF for single-molecule detection and the recently developed tetrapod PSFs for fiducial bead tracking and live axial drift correction.
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  • Lam, David P. M., et al. (author)
  • Amplifying actions for food system transformation : insights from the Stockholm region
  • 2022
  • In: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 17:6, s. 2379-2395
  • Journal article (peer-reviewed)abstract
    • Food is essential to people and is one of the main ways in which people are connected to the world’s ecosystems. However, food systems often cause ecosystem degradation and produce ill-health, which has generated increasing calls to transform food systems to be more sustainable. The Swedish food system is currently undergoing substantial change. A varied set of local actors have created alternative sustainability initiatives that enact new ways of doing, thinking, and organizing. These actors can increase the transformative impact of their initiatives through multiple actions and a variety of amplification processes. We analyzed the actions adopted by 29 food initiatives active in the Stockholm region using information available online. We conducted 11 interviews to better understand the amplification processes of speeding up (i.e., accelerating impact), scaling up (i.e., influencing higher institutional levels), and scaling deep (i.e., changing values and mind-sets). Our results indicated that the initiatives mainly seek to stabilize and grow their impact while changing the awareness, values, and mind-sets of people concerning the food they consume (scaling deep). However, these approaches raise new questions about whether these actions subvert or reinforce current unsustainable and inequitable system dynamics. We suggest there are distinct steps that local and regional governments could take to support these local actors via collaborations with coordinated forms of initiatives, and fostering changes at the municipality level, but these steps require ongoing, adaptive approaches given the highly complex nature of transformative change and the risks of reinforcing current system dynamics. 
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  • Pelaz, B, et al. (author)
  • Diverse Applications of Nanomedicine
  • 2017
  • In: ACS nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 11:3, s. 2313-2381
  • Journal article (peer-reviewed)
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  • Result 1-50 of 59

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