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Träfflista för sökning "WFRF:(Lehtinen Pekka) "

Search: WFRF:(Lehtinen Pekka)

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1.
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2.
  • Koistinen, Ville Mikael, et al. (author)
  • Side-stream products of malting: a neglected source of phytochemicals
  • 2020
  • In: npj Science of Food. - : Springer Science and Business Media LLC. - 2396-8370. ; 4:1
  • Journal article (peer-reviewed)abstract
    • Whole grain consumption reduces the risk of several chronic diseases. A major contributor to the effect is the synergistic and additive effect of phytochemicals. Malting is an important technological method to process whole grains; the main product, malted grain, is used mainly for brewing, but the process also yields high amounts of side-stream products, such as rootlet. In this study, we comprehensively determined the phytochemical profile of barley, oats, rye, and wheat in different stages of malting and the subsequent extraction phases to assess the potential of malted products and side-streams as a dietary source of bioactive compounds. Utilizing semi-quantitative LC–MS metabolomics, we annotated 285 phytochemicals from the samples, belonging to more than 13 chemical classes. Malting significantly altered the levels of the compounds, many of which were highly increased in the rootlet. Whole grain cereals and the malting products were found to be a diverse and rich source of phytochemicals, highlighting the value of these whole foods as a staple. The characterization of phytochemicals from the 24 different sample types revealed previously unknown existence of some of the compound classes in certain species. The rootlet deserves more attention in human nutrition, rather than its current use mainly as feed, to benefit from its high content of bioactive components.
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3.
  • Kulmala, Markku, et al. (author)
  • Direct Observations of Atmospheric Aerosol Nucleation
  • 2013
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 339:6122, s. 943-946
  • Journal article (peer-reviewed)abstract
    • Atmospheric nucleation is the dominant source of aerosol particles in the global atmosphere and an important player in aerosol climatic effects. The key steps of this process occur in the sub-2-nanometer (nm) size range, in which direct size-segregated observations have not been possible until very recently. Here, we present detailed observations of atmospheric nanoparticles and clusters down to 1-nm mobility diameter. We identified three separate size regimes below 2-nm diameter that build up a physically, chemically, and dynamically consistent framework on atmospheric nucleation-more specifically, aerosol formation via neutral pathways. Our findings emphasize the important role of organic compounds in atmospheric aerosol formation, subsequent aerosol growth, radiative forcing and associated feedbacks between biogenic emissions, clouds, and climate.
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4.
  • Lehtinen, Matti, et al. (author)
  • Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers : Population-based follow-up of a cluster-randomised trial
  • 2021
  • In: BMJ Open. - : BMJ. - 2044-6055. ; 11:12
  • Journal article (peer-reviewed)abstract
    • Background Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific protection against invasive cancer. Methods Individually and/or cluster randomised cohorts of HPV-vaccinated and non-vaccinated women were enrolled in 2002-2005. HPV vaccine cohorts comprised originally 16-17 year-old HPV 16/18-vaccinated PATRICIA (NCT00122681) and 012 trial (NCT00169494) participants (2465) and HPV6/11/16/18-vaccinated FUTURE II (NCT00092534) participants (866). Altogether, 3341 vaccines were followed by the Finnish Cancer Registry in the same way as 16 526 non-HPV-vaccinated controls. The control cohort stemmed from 15 665 originally 18-19 years-old women enrolled in 2003 (6499) or 2005 (9166) and 861 placebo recipients of the FUTURE II trial. The follow-up started 6 months after the clinical trials in 2007 and 2009 and ended in 2019. It was age aligned for the cohorts. Findings During a follow-up time of up to 11 years, we identified 17 HPV-positive invasive cancer cases (14 cervical cancers, 1 vaginal cancer, 1 vulvar cancer and 1 tongue cancer) in the non-HPV-vaccinated cohorts and no cases in the HPV-vaccinated cohorts. HPV typing of diagnostic tumour blocks found HPV16 in nine cervical cancer cases, HPV18, HPV33 and HPV52 each in two cases and HPV45 in one cervical cancer case. The vaginal, vulvar and tongue cancer cases were, respectively, positive for HPV16, HPV52/66 and HPV213. Intention-to-treat vaccine efficacy against all HPV-positive cancers was 100% (95% CI 2 to 100, p<0.05). Interpretation Vaccination is effective against invasive HPV-positive cancer. Trial registration number NCT00122681, Post-results; NCT00169494, Post-results; NCT00092534, Post-results.
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5.
  • Pukkala, Eero, et al. (author)
  • Nordic biological specimen banks as basis for studies of cancer causes and control - more than 2 million sample donors, 25 million person years and 100 000 prospective cancers
  • 2007
  • In: Acta Oncologica. - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 46:3, s. 286-307
  • Journal article (peer-reviewed)abstract
    • The Nordic countries have a long tradition of large-scale biobanking and comprehensive, population-based health data registries linkable on unique personal identifiers, enabling follow-up studies spanning many decades. Joint Nordic biobank-based studies provide unique opportunities for longitudinal molecular epidemiological research. The purpose of the present paper is to describe the possibilities for such joint studies, by describing some of the major Nordic biobank cohorts with a standardised calculation of the cancer incidence in these cohorts. Altogether two million donors have since 1966 donated more than four million biological samples, stored at -20 degrees C to -135 degrees C, to 17 biobank cohorts in Finland, Iceland, Norway and Sweden. As a result of joint database handling principles, the accuracy of personal identifiers and completeness of follow-up for vital status in all participating biobanks was improved. Thereafter, the cancer incidence was determined using follow-up through the national cancer registries. Biobanks based on random samples of population typically showed slightly lower cancer incidence rates than the general population, presumably due to better participation rates among health-conscious subjects. On the other hand, biobanks including samples for viral screening or clinical testing showed 1.5 to 2.1 fold increased incidence of cancer. This excess was very high immediately after sampling, but for some cancer sites remained elevated for years after clinical sampling. So far, more than 100 000 malignant neoplasms have occurred after sample donation, and the annual increase of the cancer cases in these cohorts is about 10 000. The estimates on the population-representativity of the biobanks will assist in interpretation of generalizability of results of future studies based on these samples, and the systematic tabulations of numbers of cancer cases will serve in study power estimations. The present paper summarizes optimal study designs of biobank-based studies of cancer.
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6.
  • Stålstedt, Jeanette, et al. (author)
  • Checklist of Terrestrial Parasitengona mites (Acariformes: Prostigmata) in Fennoscandia
  • Other publication (other academic/artistic)abstract
    • The knowledge on terrestrial Parasitengona in Fennoscandia lies far behind that of the aquatic counterpart, the water mites (Hydrachnidia). Based on new inventories we provide primary data and an annotated checklist of terrestrial Parasitengona in Fennoscandia including 105 species. Out of these, twenty species are new findings for the region and five are potential new species for science. Eighteen species are new for Norway, fifteen for Finland and eight for Sweden. The known recorded fauna today of terrestrial Parasitengona is 73 species for Norway, 47 for Sweden and 47 for Finland. Primary data include georeferenced locality data as well as collecting techniques and microhabitat to increase the knowledge on species' habitat requirements.
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7.
  • Stålstedt, Jeanette, et al. (author)
  • Checklist of terrestrial Parasitengona mites in Fennoscandia with new species- and distribution records (Acariformes: Prostigmata)
  • 2019
  • In: Biodiversity Data Journal. - 1314-2836 .- 1314-2828. ; 7
  • Journal article (peer-reviewed)abstract
    • The knowledge of terrestrial Parasitengona in Fennoscandia lies far behind that of their aquatic counterparts, the water mites (Hydrachnidia). Based on new inventories, we provide primary data and an annotated checklist of terrestrial Parasitengona in Fennoscandia including 107 species. Out of these, nineteen species are new findings for the region and five are species potentially new for science. Twenty-three species are new for Norway, fourteen for Finland and eleven for Sweden. The known recorded fauna today of terrestrial Parasitengona is 80 species for Norway, 54 for Sweden and 48 for Finland. Primary data include georeferenced locality data as well as collecting techniques and microhabitat to increase the knowledge on species' habitat requirements.
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  • Result 1-7 of 7
Type of publication
journal article (6)
other publication (1)
Type of content
peer-reviewed (6)
other academic/artistic (1)
Author/Editor
Dillner, Joakim (3)
Lehtinen, Matti (3)
Luostarinen, Tapio (3)
Stattin, Pär (2)
Hallmans, Göran (2)
Tenkanen, Leena (2)
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Paavonen, J (1)
Lenner, Per (1)
Widell, Anders (1)
Riipinen, Ilona (1)
Berglund, Göran (1)
Wadell, Göran (1)
Koistinen, Ville Mik ... (1)
Hanhineva, Kati, 197 ... (1)
Virtamo, Jarmo (1)
Bergsten, Johannes, ... (1)
Hakulinen, Timo (1)
Tryggvadottir, Laufe ... (1)
Knekt, Paul (1)
Schobesberger, Siegf ... (1)
Duplissy, Jonathan (1)
Franchin, Alessandro (1)
Hakala, Jani (1)
Jokinen, Tuija (1)
Junninen, Heikki (1)
Kangasluoma, Juha (1)
Kurten, Theo (1)
Laaksonen, Ari (1)
Lehtipalo, Katrianne (1)
Nieminen, Tuomo (1)
Ruuskanen, Taina (1)
Kulmala, Markku (1)
Worsnop, Douglas R. (1)
Gislefoss, Randi (1)
Eriksson, Tiina (1)
Anttila, Tarja (1)
Lumme, Sonja (1)
Leinonen, Maija (1)
Gislefoss, Randi Eli ... (1)
Thoresen, Steinar (1)
Saikku, Pekka (1)
Hakama, Matti (1)
Jousilahti, Pekka (1)
Lagheden, Camilla (1)
Bäck, Jaana (1)
Hakola, Hannele (1)
Kerminen, Veli-Matti (1)
Kontkanen, Jenni (1)
Petäjä, Tuukka (1)
Smith, James N. (1)
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University
Stockholm University (3)
Lund University (3)
Karolinska Institutet (3)
Umeå University (2)
Chalmers University of Technology (1)
Swedish Museum of Natural History (1)
Language
English (7)
Research subject (UKÄ/SCB)
Natural sciences (4)
Medical and Health Sciences (3)
Engineering and Technology (1)
Agricultural Sciences (1)

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