1. |
- Brath, Manfred, et al.
(författare)
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Microwave and submillimeter wave scattering of oriented ice particles
- 2020
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Ingår i: Atmospheric Measurement Techniques. - : Copernicus GmbH. - 1867-1381 .- 1867-8548. ; 13:5, s. 2309-2333
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Tidskriftsartikel (refereegranskat)abstract
- Microwave (1-300GHz) dual-polarization measurements above 100GHz are so far sparse, but they consistently show polarized scattering signals of ice clouds. Existing scattering databases of realistically shaped ice crystals for microwaves and submillimeter waves (> 300GHz) typically assume total random orientation, which cannot explain the polarized signals. Conceptual models show that the polarization signals are caused by oriented ice particles. Only a few works that consider oriented ice crystals exist, but they are limited to microwaves only. Assuming azimuthally randomly oriented ice particles with a fixed but arbitrary tilt angle, we produced scattering data for two particle habits (51 hexagonal plates and 18 plate aggregates), 35 frequencies between 1 and 864GHz, and 3 temperatures (190, 230 and 270K). In general, the scattering data of azimuthally randomly oriented particles depend on the incidence angle and two scattering angles, in contrast to total random orientation, which depends on a single angle. The additional tilt angle further increases the complexity. The simulations are based on the discrete dipole approximation in combination with a self-developed orientation averaging approach. The scattering data are publicly available from Zenodo (https://doi.org/10.5281/zenodo.3463003). This effort is also an essential part of preparing for the upcoming Ice Cloud Imager (ICI) that will perform polarized observations at 243 and 664GHz. Using our scattering data radiative transfer simulations with two liquid hydrometeor species and four frozen hydrometeor species of polarized Global Precipitation Measurement (GPM) Microwave Imager (GMI) observations at 166GHz were conducted. The simulations recreate the observed polarization patterns. For slightly fluttering snow and ice particles, the simulations show polarization differences up to 11K using plate aggregates for snow, hexagonal plates for cloud ice and totally randomly oriented particles for the remaining species. Simulations using strongly fluttering hexagonal plates for snow and ice show similar polarization signals. Orientation, shape and the hydrometeor composition affect the polarization. Ignoring orientation can cause a negative bias for vertically polarized observations and a positive bias for horizontally polarized observations.
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2. |
- Buehler, Stefan, et al.
(författare)
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Absorption lookup tables in the radiative transfer model ARTS
- 2011
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0022-4073 .- 1879-1352. ; 112:10, s. 1559-1567
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Tidskriftsartikel (refereegranskat)abstract
- We describe the lookup table approach that is used to store pre-calculated absorption data in the radiative transfer model ARTS. The table stores absorption cross sections as a function of frequency, pressure, temperature, and the water vapor volume mixing ratio, where the last dimension is only included for those gas species that require it. The table is used together with an extraction strategy, which uses polynomial interpolation, with recommended interpolation orders between five and seven. We also derived recommended default settings for grid spacings and interpolation orders, and verified that the approach gives very accurate results with these default settings. The tested instrument setups were for AMSU-B, HIRS, and Odin, three well-known satellite remote sensing instruments covering a wide range of frequencies and viewing geometries. Errors introduced by the lookup table were found to be always below a few millikelvin, in terms of the simulated brightness temperature.
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3. |
- Chernenk, Kirill, et al.
(författare)
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Performance and characterization of the FinEstBeAMS beamline at the MAX IV Laboratory
- 2021
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Ingår i: Journal of Synchrotron Radiation. - 0909-0495. ; 28, s. 1620-1630
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Tidskriftsartikel (refereegranskat)abstract
- FinEstBeAMS (Finnish-Estonian Beamline for Atmospheric and Materials Sciences) is a multidisciplinary beamline constructed at the 1.5 GeV storage ring of the MAX IV synchrotron facility in Lund, Sweden. The beamline covers an extremely wide photon energy range, 4.5-1300 eV, by utilizing a single elliptically polarizing undulator as a radiation source and a single grazing-incidence plane grating monochromator to disperse the radiation. At photon energies below 70 eV the beamline operation relies on the use of optical and thin-film filters to remove higher-order components from the monochromated radiation. This paper discusses the performance of the beamline, examining such characteristics as the quality of the gratings, photon energy calibration, photon energy resolution, available photon flux, polarization quality and focal spot size.
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4. |
- Demichev, Vadim, et al.
(författare)
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A proteomic survival predictor for COVID-19 patients in intensive care
- 2022
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Ingår i: PLOS Digital Health. - : Public Library of Science (PLoS). - 2767-3170. ; 1:1 January
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Tidskriftsartikel (refereegranskat)abstract
- Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely ill COVID-19 patients. Additional tools are also needed to monitor treatment, including experimental therapies in clinical trials. Comprehensively capturing human physiology, we speculated that proteomics in combination with new data-driven analysis strategies could produce a new generation of prognostic discriminators. We studied two independent cohorts of patients with severe COVID-19 who required intensive care and invasive mechanical ventilation. SOFA score, Charlson comorbidity index, and APACHE II score showed limited performance in predicting the COVID-19 outcome. Instead, the quantification of 321 plasma protein groups at 349 timepoints in 50 critically ill patients receiving invasive mechanical ventilation revealed 14 proteins that showed trajectories different between survivors and non-survivors. A predictor trained on proteomic measurements obtained at the first time point at maximum treatment level (i.e. WHO grade 7), which was weeks before the outcome, achieved accurate classification of survivors (AUROC 0.81). We tested the established predictor on an independent validation cohort (AUROC 1.0). The majority of proteins with high relevance in the prediction model belong to the coagulation system and complement cascade. Our study demonstrates that plasma proteomics can give rise to prognostic predictors substantially outperforming current prognostic markers in intensive care.
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5. |
- Demichev, Vadim, et al.
(författare)
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A time-resolved proteomic and prognostic map of COVID-19
- 2021
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Ingår i: Cell Systems. - : Elsevier BV. - 2405-4712 .- 2405-4720. ; 12:8, s. 780-794.e7
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Tidskriftsartikel (refereegranskat)abstract
- COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.
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6. |
- Eriksson, Patrick, 1964, et al.
(författare)
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ARTS, the atmospheric radiative transfer simulator, Version 2
- 2011
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0022-4073 .- 1879-1352. ; 112:10, s. 1551-1558
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Tidskriftsartikel (refereegranskat)abstract
- The second version of the atmospheric radiative transfer simulator. ARTS, is introduced. This is a general software package for long wavelength radiative transfer simulations, with a focus on passive microwave observations. The core part provides a workspace environment, in line with script languages. New for this version is an agenda mechanism that gives a high degree of modularity. The framework is intended to be as general as possible: the polarisation state can be fully described, the model atmosphere can be one- (1D), two- (2D) or three-dimensional (3D), a full description of geoid and surface is possible, observation geometries from the ground, from satellite, and from aeroplane or balloon are handled, and surface reflection can be treated in simple or complex manners. Remote sensing applications are supported by a comprehensive and efficient treatment of sensor characteristics. jacobians can be calculated for the most important atmospheric variables in non-scattering conditions. Finally, the most prominent feature is the rigorous treatment of scattering that has been implemented in two modules: a discrete ordinate iterative approach mainly used for 1D atmospheres, and a Monte Carlo approach which is the preferred algorithm for 3D atmospheres. ARTS is freely available, and maintained as an open-source project.
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7. |
- Gasteiger, J., et al.
(författare)
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Representative wavelengths absorption parameterization applied to satellite channels and spectral bands
- 2014
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0022-4073 .- 1879-1352. ; 148, s. 99-115
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Tidskriftsartikel (refereegranskat)abstract
- Accurate modeling of wavelength-integrated radiative quantities, e.g. integrated over a spectral band or an instrument channel response function, requires computations for a large number of wavelengths if the radiation is affected by gas absorption which typically comprises a complex line structure. In order to increase computational speed of modeling radiation in the Earth׳s atmosphere, we parameterized wavelength-integrals as weighted means over representative wavelengths. We parameterized spectral bands of different widths (1 cm−1, 5 cm−1, and 15 cm−1) in the solar and thermal spectral range, as well as a number of instrument channels on the ADEOS, ALOS, EarthCARE, Envisat, ERS, Landsat, MSG, PARASOL, Proba, Sentinel, Seosat, and SPOT satellites. A root mean square relative deviation lower than 1% from a “training data set” was selected as the accuracy threshold for the parameterization of each band and channel. The training data set included high spectral resolution calculations of radiances at the top of atmosphere for a set of highly variable atmospheric states including clouds and aerosols. The gas absorption was calculated from the HITRAN 2004 spectroscopic data set and state-of-the-art continuum models using the ARTS radiative transfer model. Three representative wavelengths were required on average to fulfill the accuracy threshold. We implemented the parameterized spectral bands and satellite channels in the uvspec radiative transfer model which is part of the libRadtran software package. The parameterization data files, including the representative wavelengths and weights as well as lookup tables of absorption cross sections of various gases, are provided at the libRadtran webpage.In the paper we describe the parameterization approach and its application. We validate the approach by comparing modeling results of parameterized bands and channels with results from high spectral resolution calculations for atmospheric states that were not part of the training data set. Irradiances are not only compared at the top of atmosphere but also at the surface for which this parameterization approach was not optimized. It is found that the parameterized bands and channels provide a good compromise between computation time requirements and uncertainty for typical radiative transfer problems. In particular for satellite radiometer simulations the computation time requirement and the parameterization uncertainty is low. Band-integrated irradiances at any level as well as heating and cooling rates below 20 km can also be modeled with low uncertainty.
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8. |
- Mendrok, Jana, et al.
(författare)
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ARTS+ - A toolbox for microwave atmospheric radiative transfer in solar system planets
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Microwave and (sub)millimetre-wave frequencies have long been of interest for remote sensing of the Earth and space objects. They suffer less from interference by small particles (dust, clouds), hence penetrate deeper into atmospheres revealing their deeper structures hidden to shorter wavelengths, and possess characteristic line absorption features of many gaseous species, which are of interest for the understanding of atmospheric chemistry and dynamics.Models simulating radiative transfer and wave propagation (RT/WP) have been developed by many institutions. Most of them are designed for a particular, narrow region of the electromagnetic spectrum, certain instrument types or missions, and specific atmospheric conditions. In particular, they are usually set up for a specific planetary body. This high level of specialisation allows for accurate modelling results. However, it also limits the flexibility of those models and comparability between them.For various applications there is a demand on easy and quick calculations of propagation characteristics, like feasibility estimates of missions proposed to space agencies and performance estimates of radiocommunication links between satellites or orbiter and lander.Within an ESA study we have developed a toolbox for microwave RT/WP in planetary atmospheres. The toolbox consists of the RT/WP model and a data package. The RT/WP model is a largely revised and extended version of ARTS, a sophisticated, flexible RT model for Earth atmosphere (3D spherical geometry, diverse absorption models, scattering, polarization, Jacobians). Focus has been on creating a consistent, physics-based model. Several features have been added (radio link and cloud radar modes, zeeman splitting, doppler shifts). A new spectroscopic approach has been implemented considering effects of a range of broadening/pressure-shifting/refracting species, a corresponding spectroscopic line catalogue designed and prepared. At the current state, the data package contains atmospheric and surface data for Earth and the planets Venus, Mars, and Jupiter, but is easily extendable.We will illustrate the capabilities of the toolbox introducing several example cases and presenting results from the toolbox validation.
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9. |
- Vernardis,, et al.
(författare)
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The Impact of Acute Nutritional Interventions on the Plasma Proteome
- 2023
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 108:8, s. 2087-2098
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Tidskriftsartikel (refereegranskat)abstract
- Context: Humans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses. Objective: Endocrine parameters and the metabolome of human plasma are rapidly responding to acute nutritional interventions such as caloric restriction or a glucose challenge. It is less well understood whether the plasma proteome would be equally dynamic, and whether it could be a source of corresponding biomarkers. Methods: We used high-throughput mass spectrometry to determine changes in the plasma proteome of i) 10 healthy, young, male individuals in response to 2 days of acute caloric restriction followed by refeeding; ii) 200 individuals of the Ely epidemiological study before and after a glucose tolerance test at 4 time points (0, 30, 60, 120 minutes); and iii) 200 random individuals from the Generation Scotland study. We compared the proteomic changes detected with metabolome data and endocrine parameters. Results: Both caloric restriction and the glucose challenge substantially impacted the plasma proteome. Proteins responded across individuals or in an individual-specific manner. We identified nutrient-responsive plasma proteins that correlate with changes in the metabolome, as well as with endocrine parameters. In particular, our study highlights the role of apolipoprotein C1 (APOC1), a small, understudied apolipoprotein that was affected by caloric restriction and dominated the response to glucose consumption and differed in abundance between individuals with and without type 2 diabetes. Conclusion: Our study identifies APOC1 as a dominant nutritional responder in humans and highlights the interdependency of acute nutritional response proteins and the endocrine system.
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