SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Lind Andreas) "

Search: WFRF:(Lind Andreas)

  • Result 1-50 of 209
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • de Jong, Roelof S., et al. (author)
  • 4MOST-4-metre Multi-Object Spectroscopic Telescope
  • 2014
  • In: Ground-based and Airborne Instrumentation for Astronomy V. - : SPIE. - 0277-786X .- 1996-756X. ; 9147
  • Conference paper (peer-reviewed)abstract
    • 4MOST is a wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of the European Southern Observatory (ESO). Its main science drivers are in the fields of galactic archeology, high-energy physics, galaxy evolution and cosmology. 4MOST will in particular provide the spectroscopic complements to the large area surveys coming from space missions like Gaia, eROSITA, Euclid, and PLATO and from ground-based facilities like VISTA, VST, DES, LSST and SKA. The 4MOST baseline concept features a 2.5 degree diameter field-of-view with similar to 2400 fibres in the focal surface that are configured by a fibre positioner based on the tilting spine principle. The fibres feed two types of spectrographs; similar to 1600 fibres go to two spectrographs with resolution R> 5000 (lambda similar to 390-930 nm) and similar to 800 fibres to a spectrograph with R> 18,000 (lambda similar to 392-437 nm & 515-572 nm & 605-675 nm). Both types of spectrographs are fixed-configuration, three-channel spectrographs. 4MOST will have an unique operations concept in which 5 year public surveys from both the consortium and the ESO community will be combined and observed in parallel during each exposure, resulting in more than 25 million spectra of targets spread over a large fraction of the southern sky. The 4MOST Facility Simulator (4FS) was developed to demonstrate the feasibility of this observing concept. 4MOST has been accepted for implementation by ESO with operations expected to start by the end of 2020. This paper provides a top-level overview of the 4MOST facility, while other papers in these proceedings provide more detailed descriptions of the instrument concept[1], the instrument requirements development[2], the systems engineering implementation[3], the instrument model[4], the fibre positioner concepts[5], the fibre feed[6], and the spectrographs[7].
  •  
2.
  • Beal, Jacob, et al. (author)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Journal article (peer-reviewed)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
  •  
3.
  •  
4.
  • Bach, Andreas, et al. (author)
  • HAMNEN SOM ENERGINOD : Ett koncept för hamnens roll i omställningen mot ett hållbart transportsystem
  • 2022
  • Reports (other academic/artistic)abstract
    • Transportsystemet står inför en enorm utmaning då trycket på genomförandet av hållbara operationer aldrig varit större. Enligt IEA står transportsektorn för 16% av det totala koldioxidutsläppet i världen som med nödvändighet måste minska för att vi ska kunna lämna efter oss en planet med resurser för framtida generationer. Utmaningen kräver att alla delar av transportsystemet gör sitt bidrag, oavsett om det handlar om transportoperatörer, transportnoder, myndigheter på såväl lokal, regional som global nivå och tvärs samtliga transportslag. Det slutar dock inte där, det är lika viktigt att de som konstruerar olika typer av lastbärare och fordon för både gods- och persontransporter också beaktar den energi som förväntas vara tillgänglig i rätt kvantitet och till rätt pris. Energiproducenter behöver också tillgodose att efterfrågade energibärare produceras och finns att tillgå vid rätt plats och i tillräcklig kvantitet då den behövs. Detta är i linje med de behov av insatser som Sveriges regering lyfter inom transporteffektivitet, hållbara förnybara drivmedel samt energieffektiva fordon och fartyg, för att reducera Sveriges territoriella CO2 utsläpp i linje med de globala målen. En viktig del av transportsystemet är hamnar som har fönster mot flera olika transportslag och utgör multimodala noder som förväntas ombesörja en så sömlös övergång mellan olika transportslag som möjligt, såsom till/från sjö, järnväg och väg. Svenska hamnar är inget undantag, utan i Sverige med sin längsta europeiska kustremsa behöver Sveriges hamnar också etablera tillräcklig kapabilitet för att hantera såväl inhemska transportbehov som förväntade transporter för import och export på ett hållbart sätt. Hamnar står inför utmaningen att både bedriva sina operationer på ett så hållbart sätt som möjligt genom nyttjande av fossilfri energi, att förse besökare med fossilfria energibärare, och att balansera sitt nyttjande och distribution av hållbar energi med de behov som omgivningen har. Organisationer med lastbilar, tåg, och fartyg som besöker en transportnod, däribland hamnar, förväntar sig att de kan försörjas med viss energi. Transportnoder kan således inte bara betraktas utifrån att vara en effektiv omlastningspunkt, utan behöver också betraktas utifrån den roll som transportnoden har och kan komma att ta i den del av energisystemet som relaterar till transportsystemet. Hamnar som transportnoder behöver således etablera en förmåga som energinod. I föreliggande projekt har trender beaktats för utvecklingen inom olika transportslag, intervjuer genomförts med svenska hamnar samt en enkätundersökning genomförts riktad till en majoritet av Sveriges hamnar. I projektet identifieras att de viktigaste drivkrafterna för hamnarnas hållbarhets- och omställningsarbete är kundkrav, kostnadsbesparingar, hamnens interna målsättning (ofta baserad på ägarnas krav och vision) samt regelverk. Slutsatsen är att Sveriges hamnar har en stark ambition att utveckla sin förmåga som energinod för olika roller. Samtidigt råder en villrådighet om vilka satsningar som skulle ge störst effekter för hamnens verksamhet. Viktigt att notera är också att olika hamnar har olika förutsättningar och roller i transportsystemet, beroende på dess geografiska placering, storlek och typ av gods / passagerare som hanteras. Samtidigt görs stora investeringar i Sveriges hamnsystem, för att proaktivt utveckla en kapabilitet att möta dagens och morgondagens transportbehov, särskilt i ljuset av den omflyttning som sker från vägbundna transporter till järnväg och sjö. Det är vanligt att hamnar etablerar inlandsterminalskapabilitet, d v s skapar förmåga för omlastning mellan tåg och väg där inte någon sjötransport behöver vara inblandad. Många av Sveriges järnvägsoperatörer ser hamnar som strategiska noder i järnvägssystemet. Dessutom det är tydligt från intervjuerna, vilket även styrks av enkätsvar, att respondenterna anser att otillräckliga finansiella medel, höga kostnader och skatt, omogen teknik, infrastruktur, effekt, standardisering, kompetens, och politisk otydlighet är de största utmaningar som påverkar svenska hamnars roll i hållbarhets- och omställningsarbete. Baserat på genomförd trend- och nulägesanalys föreslås en mognadsmodell som rådgivande för hamnens proaktiva utveckling av sin energinodskapacitet. Denna modell tar utgångspunkt i att hamnen etablerar en energistrategi som tar höjd för nödvändiga samarbeten och investeringar som de både blir tvingade till genom regelverk, påverkade av genom beslut och själva har rådighet över. Hamnarna är tydliga med att huvudverksamheten är att utgöra en transportnod, men att de, för att möjliggöra en omställning mot ett hållbart transportsystem, också behöver ge utrymme för andra aktörer, såsom energiproducenter och energidistributörer att bedriva sin verksamhet relaterat till hamnens geografiska område. Således behöver det kluster av aktörer som ingår i hamnen som nod expanderas till att också innefatta producenter och distributörer av energi. Hamnens energistrategi är rådgivande för att hamnen skall kunna etablera en förmåga som säkerställer att de krav som hamnens operationer, hamnens besökare och hamnens roll med sin geografiska placering, möts. Föreslagen mognadsmodell riktar uppmärksamhet just till dessa nivåer av förmåga och skapar grunder för formuleringen av en proaktiv strategi för den enskilda hamnens roll i transportsystemets energiomställning. En viktig grund blir då att simulera framtida energibehov, såsom inom elförsörjnings- och eldistributionsområdet, men även för andra energibärare, varför detta projekt föreslår ett fortsättningsprojekt där förväntade energibehov kan simuleras och bli rådgivande för strategi, samverkan och investering för Sveriges hamnar. En sådan simuleringsmodell bygger på hamnens digitala förmåga att fånga och använda data från operationer för att säkerställa att hamnen bidrar till transporteffektivitet, användning av hållbara förnybara drivmedel samt energieffektiva fordon och fartyg. Samspelet mellan hamnen som energinod och transportbärares kapabilitet att drivas på hållbar energi samt energiproducenters/energidistributörers förmåga att tillhandahålla fossilfri energi, utgör grunden till fossilfria transporter. Fossilfria väg-, järnvägs- och sjötransporter kan således inte etableras utan att ta hänsyn till alla ingående komponenter. I denna nödvändiga transformation har hamnar och andra transportnoder en nyckelroll.
  •  
5.
  • Sundström, Johan, Professor, 1971-, et al. (author)
  • Rationale for a Swedish cohort consortium
  • 2019
  • In: Upsala Journal of Medical Sciences. - : Taylor & Francis Group. - 0300-9734 .- 2000-1967. ; 124:1, s. 21-28
  • Journal article (peer-reviewed)abstract
    • We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants' data, better return of funders' investments, and higher benefit to patients and populations. We motivate the proposed infrastructure partly by lessons learned from a pilot study encompassing data from 21 cohorts. We envisage a standing Swedish cohort consortium that would drive development of epidemiological research methods and strengthen the Swedish as well as international epidemiological competence, community, and competitiveness.
  •  
6.
  • Adibekyan, V., et al. (author)
  • Sun-like stars unlike the Sun : Clues for chemical anomalies of cool stars
  • 2017
  • In: Astronomical Notes - Astronomische Nachrichten. - : WILEY-V C H VERLAG GMBH. - 0004-6337 .- 1521-3994. ; 338:4, s. 442-452
  • Journal article (peer-reviewed)abstract
    • We present a summary of the splinter session Sun-like stars unlike the Sun that was held on June 9, 2016, as part of the Cool Stars 19 conference (Uppsala, Sweden), in which the main limitations (in the theory and observations) in the derivation of very precise stellar parameters and chemical abundances of Sun-like stars were discussed. The most important and most debated processes that can produce chemical peculiarities in solar-type stars were outlined and discussed. Finally, in an open discussion between all the participants, we tried to identify new pathways and prospects toward future solutions of the currently open questions.
  •  
7.
  • Andersson, Andreas, 1980-, et al. (author)
  • Full-Scale Dynamic Testing of a Railway Bridge Using a Hydraulic Exciter
  • 2018
  • In: EXPERIMENTAL VIBRATION ANALYSIS FOR CIVIL STRUCTURES. - Cham : SPRINGER INTERNATIONAL PUBLISHING AG. - 9783319674438 - 9783319674421 ; , s. 354-363
  • Conference paper (peer-reviewed)abstract
    • This paper presents a full-scale dynamic testing on a simply supported railway bridge with integrated end-shields, by using a hydraulic exciter. Experimental frequency response functions are determined based on load controlled frequency sweeps. Apart from accurate estimates of natural frequencies, damping and mode shapes, the experimental testing also gives valuable information about the dynamic characteristics at resonance and amplitude dependent nonlinearities. Numerical models are used to simulate the dynamic response from passing trains which is compared to experimental testing of similar train passages. The results show that the bridge deck is partially constrained due to the interaction between the end-shields and the wing walls with the surrounding soil. Measurements at the supports also show that the flexibility of the foundation needs to be accounted for. An updated numerical model is able to accurately predict the response from passing trains. The response is lower than that predicted from the initial simulations and the bridge will fulfil the design requirements regarding vertical deck acceleration.
  •  
8.
  • Andersson, Anders, et al. (author)
  • Parameterization procedure of a powertrain model for a driving simulator
  • 2016
  • In: Advances in Transportation Studies. - : Aracne editrice. - 1824-5463. ; 1, s. 99-112
  • Journal article (peer-reviewed)abstract
    • The automotive industry is facing a major challenge to reduce environmental impacts. As a consequence, the increasing diversity of powertrain configurations put a demand on testing and evaluation procedures. One of the key tools for this purpose is simulators. In this paper a powertrain model and a procedure for parameterizing it, using chassis dynamometers and a developed pedal robot are presented. The parameterizing procedure uses the on-board diagnostics of the car and does not require any additional invasive sensors.Thus, the developed powertrain model and parameterization procedure provide a rapid non- invasive way of modelling powertrains of test cars. The parameterizing procedure has been used to model a front wheel drive Golf V with a 1.4L multi-fuel engine and a manual gearbox. The achieved results show a good match between simulation results and test data. The powertrain model has also been tested in real-time in a driving simulator.
  •  
9.
  • Andersson, Anders, et al. (author)
  • Parameterization Procedure of a Powertrain Model for a Driving Simulator
  • 2015
  • In: Proceedings  of the 2015 Road Safety &amp; Simulation International Conference.
  • Conference paper (peer-reviewed)abstract
    • The automotive industry is facing a major challenge to reduce environmental impacts. As a consequence, the increasing diversity of powertrain configurations put a demand on testing and evaluation procedures. One of the key tools for this purpose is simulations.In this paper a powertrain model and a procedure for parameterizing it, using chassis dynamometers and a developed pedal robot are presented. The parameterizing procedure uses the on-board diagnostics of the car and does not require any additional invasive sensors. Thus, the developed powertrain model and parameterization procedure provide a rapid non-invasive way of modelling powertrains of test cars. The parameterizing procedure has been used to model a front wheel drive Golf V with a 1.4L multi-fuel engine and a manual gearbox. The achieved results show a good match between simulation results and test data. The powertrain model has also been tested in real-time in a driving simulator.
  •  
10.
  • Andersson, Per Ola, et al. (author)
  • A novel ATR-FTIR method for functionalised surface characterisation
  • 2008
  • In: Surface and Interface Analysis. - : Wiley. - 0142-2421 .- 1096-9918. ; 40:3-4, s. 623-626
  • Journal article (peer-reviewed)abstract
    • We demonstrate a novel method to analyse ex situ prepared chips by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), which circumvents tedious functionalisation steps of internal reflection elements (IREs), and simultaneously allows for complementary measurements by other analytical techniques. This concept is proved by utilising immobilised metal affinity capture (IMAC) chips containing about 10 gm thick films of copolymers coated with nitrilotriacetic acid (NTA) groups. With this so-called 'upside-down' ATR-FTIR technique, each chemical modification step can be followed and optimised with respect to concentration, buffer, pH, ionic strength, and so on, and there are no limitations in variations or numbers of functionalised surfaces that can be generated. We have demonstrated the feasibility of this approach to determine the molecular structure of ligand bonded to immobilised polypeptide, directly observed in the raw ATR-FTIR spectrum. Peptide adsorption in a thick NTA-copolymer matrix yields a high peptide concentration as determined by the analysis of the Langmuir adsorption isotherm. Combined with the 'upside-down' ATR-FTIR approach which samples the outermost region of the exposed NTA-copolymer film, this generates well-resolved amide I and II absorption bands that reduce the necessity of using D2O based buffers, which otherwise is common in mid-IR spectroscopy of proteins. We believe that this new optical surface characterisation method has a great potential as a stand-alone or complementary analytical tool. We emphasise further that with this approach no chemical treatment of IREs is needed; the chips can be regenerated and reused, and analysed by complementary analytical techniques such as mass spectrometry.
  •  
11.
  • Andrist B., Rafael, et al. (author)
  • Holomorphic Automorphisms of Danielewski Surfaces II: Structure of the Overshear Group
  • 2015
  • In: Journal of Geometric Analysis. - : Springer Science and Business Media LLC. - 1050-6926 .- 1559-002X. ; 25:3, s. 1859-1889
  • Journal article (peer-reviewed)abstract
    • We apply Nevanlinna theory for algebraic varieties to Danielewski surfaces and investigate their group of holomorphic automorphisms. Our main result states that the overshear group, which is known to be dense in the identity component of the holomorphic automorphism group, is a free product.
  •  
12.
  • Baker, Brett J., et al. (author)
  • Genomic inference of the metabolism of cosmopolitan subsurface Archaea, Hadesarchaea
  • 2016
  • In: Nature Microbiology. - 2058-5276. ; 1:3
  • Journal article (peer-reviewed)abstract
    • The subsurface biosphere is largely unexplored and contains a broad diversity of uncultured microbes(1). Despite being one of the few prokaryotic lineages that is cosmopolitan in both the terrestrial and marine subsurface(2-4), the physiological and ecological roles of SAGMEG (South-African Gold Mine Miscellaneous Euryarchaeal Group) Archaea are unknown. Here, we report the metabolic capabilities of this enigmatic group as inferred from genomic reconstructions. Four high-quality (63-90% complete) genomes were obtained from White Oak River estuary and Yellowstone National Park hot spring sediment metagenomes. Phylogenomic analyses place SAGMEG Archaea as a deeply rooting sister clade of the Thermococci, leading us to propose the name Hadesarchaea for this new Archaeal class. With an estimated genome size of around 1.5 Mbp, the genomes of Hadesarchaea are distinctly streamlined, yet metabolically versatile. They share several physiological mechanisms with strict anaerobic Euryarchaeota. Several metabolic characteristics make them successful in the subsurface, including genes involved in CO and H-2 oxidation (or H-2 production), with potential coupling to nitrite reduction to ammonia (DNRA). This first glimpse into the metabolic capabilities of these cosmopolitan Archaea suggests they are mediating key geochemical processes and are specialized for survival in the subsurface biosphere.
  •  
13.
  • Becher, Christoph, et al. (author)
  • High degree of consensus amongst an expert panel regarding focal resurfacing of chondral and osteochondral lesions of the femur with mini-implants
  • 2023
  • In: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Nature. - 0942-2056 .- 1433-7347. ; 31:9, s. 4027-4034
  • Journal article (peer-reviewed)abstract
    • Introduction: The rationale for the use of mini-implants for partial resurfacing in the treatment of femoral chondral and osteochondral lesions is still under debate. The evidence supporting best practise guidelines is based on studies with low-level evidence. A consensus group of experts was convened to collaboratively advance towards consensus opinions regarding the best available evidence. The purpose of this article is to report the resulting consensus statements.Methods: Twenty-five experts participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted via an online survey of two rounds, for initial agreement and comments on the proposed statements. An in-person meeting between the panellists was organised during the 2022 ESSKA congress to further discuss and debate each of the statements. A final agreement was made via a final online survey a few days later. The strength of consensus was characterised as: consensus, 51–74% agreement; strong consensus, 75–99% agreement; unanimous, 100% agreement.Results: Statements were developed in the fields of patient assessment and indications, surgical considerations and postoperative care. Between the 25 statements that were discussed by this working group, 18 achieved unanimous, whilst 7 strong consensus.Conclusion: The consensus statements, derived from experts in the field, represent guidelines to assist clinicians in decision-making for the appropriate use of mini-implants for partial resurfacing in the treatment of femoral chondral and osteochondral lesions. Level of evidence: Level V.
  •  
14.
  • Becher, Christoph, et al. (author)
  • High degree of consensus amongst an expert panel regarding focal resurfacing of chondral and osteochondral lesions of the femur with mini-implants
  • 2023
  • In: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Nature. - 0942-2056 .- 1433-7347. ; 31:9, s. 4027-4034
  • Journal article (peer-reviewed)abstract
    • Introduction: The rationale for the use of mini-implants for partial resurfacing in the treatment of femoral chondral and osteochondral lesions is still under debate. The evidence supporting best practise guidelines is based on studies with low-level evidence. A consensus group of experts was convened to collaboratively advance towards consensus opinions regarding the best available evidence. The purpose of this article is to report the resulting consensus statements. Methods: Twenty-five experts participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted via an online survey of two rounds, for initial agreement and comments on the proposed statements. An in-person meeting between the panellists was organised during the 2022 ESSKA congress to further discuss and debate each of the statements. A final agreement was made via a final online survey a few days later. The strength of consensus was characterised as: consensus, 51–74% agreement; strong consensus, 75–99% agreement; unanimous, 100% agreement. Results: Statements were developed in the fields of patient assessment and indications, surgical considerations and postoperative care. Between the 25 statements that were discussed by this working group, 18 achieved unanimous, whilst 7 strong consensus. Conclusion: The consensus statements, derived from experts in the field, represent guidelines to assist clinicians in decision-making for the appropriate use of mini-implants for partial resurfacing in the treatment of femoral chondral and osteochondral lesions. Level of evidence: Level V.
  •  
15.
  • Bergemann, M., et al. (author)
  • The Gaia-ESO Survey : radial metallicity gradients and age-metallicity relation of stars in the Milky Way disk
  • 2014
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 565, s. A89-
  • Journal article (peer-reviewed)abstract
    • We study the relationship between age, metallicity, and alpha-enhancement of FGK stars in the Galactic disk. The results are based upon the analysis of high-resolution UVES spectra from the Gaia-ESO large stellar survey. We explore the limitations of the observed dataset, i.e. the accuracy of stellar parameters and the selection effects that are caused by the photometric target preselection. We find that the colour and magnitude cuts in the survey suppress old metal-rich stars and young metal-poor stars. This suppression may be as high as 97% in some regions of the age-metallicity relationship. The dataset consists of 144 stars with a wide range of ages from 0.5 Gyr to 13.5 Gyr, Galactocentric distances from 6 kpc to 9.5 kpc, and vertical distances from the plane 0 < vertical bar Z vertical bar < 1.5 kpc. On this basis, we find that i) the observed age-metallicity relation is nearly flat in the range of ages between 0 Gyr and 8 Gyr; ii) at ages older than 9 Gyr, we see a decrease in [Fe/H] and a clear absence of metal-rich stars; this cannot be explained by the survey selection functions; iii) there is a significant scatter of [Fe/H] at any age; and iv) [Mg/Fe] increases with age, but the dispersion of [Mg/Fe] at ages > 9 Gyr is not as small as advocated by some other studies. In agreement with earlier work, we find that radial abundance gradients change as a function of vertical distance from the plane. The [Mg/Fe] gradient steepens and becomes negative. In addition, we show that the inner disk is not only more alpha-rich compared to the outer disk, but also older, as traced independently by the ages and Mg abundances of stars.
  •  
16.
  • Bergman, Åke, et al. (author)
  • Manufacturing doubt about endocrine disrupter science : A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012"
  • 2015
  • In: Regulatory toxicology and pharmacology. - : Academic Press. - 0273-2300 .- 1096-0295. ; 73:3, s. 1007-1017
  • Journal article (peer-reviewed)abstract
    • We present a detailed response to the critique of "State of the Science of Endocrine Disrupting Chemicals 2012" (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford-Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers not intimately familiar with the topic of endocrine disruption and therefore susceptible to false generalizations of bias and subjectivity.
  •  
17.
  • Bergman, Åke, et al. (author)
  • Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
  • 2013
  • In: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
  • Journal article (peer-reviewed)abstract
    • The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
  •  
18.
  • Bordoni, Federica, et al. (author)
  • Unconventional sources of error in high-resolution wide-swath SAR systems based on scan-on-receive
  • 2021
  • In: EUSAR 2021 - 13th European Conference on Synthetic Aperture Radar, Proceedings. - 2197-4403. - 9783800754571 ; 2021-March, s. 1116-1119
  • Conference paper (peer-reviewed)abstract
    • The scan-on-receive (SCORE) is a key digital beamforming (DBF) technique for future high-resolution wide-swath synthetic aperture radar (SAR) systems. A sharp and high gain receive beam, steered in real time towards the expected direction of arrival (DoA) of the backscattering signal, allows for improved SAR imaging performance with respect to a conventional approach. Nevertheless, it also exposes the system to new errors, associated with a mismatch between the expected and the actual DoA. This paper identifies possible sources of error, specific of SCORE-based systems, and investigates their effect on the SAR image quality in dependence of instrument and geometrical parameters.
  •  
19.
  • Brittberg, Mats, 1953, et al. (author)
  • Cartilage repair in the degenerative ageing knee.
  • 2016
  • In: Acta orthopaedica. - : Medical Journals Sweden AB. - 1745-3682 .- 1745-3674. ; 87:supl. 363, s. 26-38
  • Journal article (peer-reviewed)abstract
    • Background and purpose - Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists. A group of clinicians was given the task of discussing the role of tissue engineering in the treatment of degenerative cartilage lesions in ageing patients. We present the outcomes of our discussions on current treatment options for such lesions, with particular emphasis on different biological repair techniques and their supporting level of evidence. Results and interpretation - Based on the studies on treatment of degenerative lesions and early OA, there is low-level evidence to suggest that cartilage repair is a possible treatment for such lesions, but there are conflicting results regarding the effect of advanced age on the outcome. We concluded that further improvements are needed for direct repair of focal, purely traumatic defects before we can routinely use such repair techniques for the more challenging degenerative lesions. Furthermore, we need to identify trigger mechanisms that start generalized loss of cartilage matrix, and induce subchondral bone changes and concomitant synovial pathology, to maximize our treatment methods for biological repair in degenerative ageing joints.
  •  
20.
  • Broadaway, K Alaine, et al. (author)
  • Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
  • 2023
  • In: American Journal of Human Genetics. - : Elsevier. - 0002-9297 .- 1537-6605. ; 110:2, s. 284-299
  • Journal article (peer-reviewed)abstract
    • Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. We conducted meta-analyses of genome-wide association results for fasting proinsulin from 16 European-ancestry studies in 45,861 individuals. We found 36 independent signals at 30 loci (p value < 5 × 10-8), which validated 12 previously reported loci for proinsulin and ten additional loci previously identified for another glycemic trait. Half of the alleles associated with higher proinsulin showed higher rather than lower effects on glucose levels, corresponding to different mechanisms. Proinsulin loci included genes that affect prohormone convertases, beta-cell dysfunction, vesicle trafficking, beta-cell transcriptional regulation, and lysosomes/autophagy processes. We colocalized 11 proinsulin signals with islet expression quantitative trait locus (eQTL) data, suggesting candidate genes, including ARSG, WIPI1, SLC7A14, and SIX3. The NKX6-3/ANK1 proinsulin signal colocalized with a T2D signal and an adipose ANK1 eQTL signal but not the islet NKX6-3 eQTL. Signals were enriched for islet enhancers, and we showed a plausible islet regulatory mechanism for the lead signal in the MADD locus. These results show how detailed genetic studies of an intermediate phenotype can elucidate mechanisms that may predispose one to disease.
  •  
21.
  • Brändström, Helena, et al. (author)
  • A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function
  • 2002
  • In: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 293:1, s. 13-17
  • Journal article (peer-reviewed)abstract
    • Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and has previously been shown to regulate bone mass by inhibiting osteoclast differentiation and activation. Recent evidence indicates that OPG also plays a role in the vascular system, since ablation of the OPG gene in mice results in calcification of the aorta and renal arteries, and association has been found between serum levels of OPG and cardiovascular mortality. This study presents a novel single nucleotide polymorphism, a T/C transition located 129 bp upstream the TATA-box of the human OPG gene, detected by sequence analysis. The OPG genotype was determined by restriction fragment length polymorphism in a cohort consisting of 59 healthy subjects. The intima-media thickness (IMT) in the common carotid artery and maximal post-ischemic forearm blood flow (FBF) were investigated. Subjects with the CC genotype showed a significantly increased IMT (p<0.05) and a concommitantly reduced maximal FBF (p<0.01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects.
  •  
22.
  • Brändström, Helena, et al. (author)
  • A single nucleotide polymorphism in the promoter region of the osteoprotegerin gene is related to intima-media thickness of the carotid artery in hypertensive patients : The Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA)
  • 2004
  • In: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 13:3, s. 152-157
  • Journal article (peer-reviewed)abstract
    • Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and in previous studies has been shown to regulate osteoclast activity and differentiation. Ablation of the OPG gene in mice results in calcification of the aorta and renal arteries. We have previously reported an association between a single nucleotide polymorphism in the promoter region of OPG and vascular morphology and function in healthy humans. The objective with this study was to confirm our previous results in a larger population, and in addition, to study subjects with hypertension. The OPG genotype was determined by restriction fragment length and the intima-media thickness (IMT) of the common carotid artery was measured by ultrasound in 100 patients with hypertension and left ventricular hypertrophy, and 75 healthy normotensive control subjects. In the hypertensive group subjects with the CC genotype (n=24) showed a significantly increased IMT compared to those with the TC (n=52, p=0.007) and TT (n=24, p=0.009) genotype, in the hypertensive group only (mean +/- SD for TT=0.88 +/- 0.21 mm, TC=0.90 +/- 0.16 mm, CC=1.05 +/- 0.31 mm). The allele distribution did not differ between hypertensive and control individuals. The present study confirms our previous finding and shows that polymorphism in the promoter region of OPG is associated with vascular morphology in hypertensive subjects.
  •  
23.
  • Casey, A. R., et al. (author)
  • The Gaia-ESO Survey : Revisiting the Li-rich giant problem
  • 2016
  • In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 461:3, s. 3336-3352
  • Journal article (peer-reviewed)abstract
    • The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey, which includes the first nine Li-rich giant stars known towards the CoRoT fields. Most of our Li-rich giants have near-solar metallicities and stellar parameters consistent with being before the luminosity bump. This is difficult to reconcile with deep mixing models proposed to explain lithium enrichment, because these models can only operate at later evolutionary stages: at or past the luminosity bump. In an effort to shed light on the Li-rich phenomenon, we highlight recent evidence of the tidal destruction of close-in hot Jupiters at the sub-giant phase.We note that when coupled with models of planet accretion, the observed destruction of hot Jupiters actually predicts the existence of Li-rich giant stars, and suggests that Li-rich stars should be found early on the giant branch and occur more frequently with increasing metallicity. A comprehensive review of all known Li-rich giant stars reveals that this scenario is consistent with the data. However, more evolved or metal-poor stars are less likely to host close-in giant planets, implying that their Li-rich origin requires an alternative explanation, likely related to mixing scenarios rather than external phenomena.
  •  
24.
  • Cedheim, Erik, et al. (author)
  • Kelb - A Real-Time Programming Environment for the Sony Aibo
  • 2004
  • Reports (other academic/artistic)abstract
    • Kelb is a new real-time programming environment developed at Uppsala University for the Sony AIBO ERS-210. It is aimed to provide efficiency by introducing a notion of light-weight tasks executing according to well-known real-time scheduling algorithms and resource protocols, while still allowing applications to be developed in a high-level abstract programming language. In this paper we give an overview of the design of Kelb and describe the status of the environment, currently including: a real-time programming language and compiler extending gcc for MIPS with support for time- and event-triggered tasks, a runtime library with support for static and dynamic preemptive scheduling algorithms (e.g. fixed priority and earliest deadline first), and a prototype connection to the Times tool allowing Kelb designs to be analysed for schedulabilty.
  •  
25.
  •  
26.
  • Christleib, Norbert, et al. (author)
  • 4MOST Consortium Survey 2: The Milky Way Halo High-Resolution Survey
  • 2019
  • In: Messenger. - 0722-6691. ; 175, s. 26-29
  • Journal article (other academic/artistic)abstract
    • We will study the formation history of the Milky Way, and the earliest phases of its chemical enrichment, with a sample of more than 1.5 million stars at high galactic latitude. Elemental abundances of up to 20 elements with a precision of better than 0.2 dex will be derived for these stars. The sample will include members of kinematically coherent substructures, which we will associate with their possible birthplaces by means of their abundance signatures and kinematics, allowing us to test models of galaxy formation. Our target catalogue is also expected to contain 30 000 stars at a metallicity of less than one hundredth that of the Sun. This sample will therefore be almost a factor of 100 larger than currently existing samples of metal-poor stars for which precise elemental abundances are available (determined from high-resolution spectroscopy), enabling us to study the early chemical evolution of the Milky Way in unprecedented detail.
  •  
27.
  • Christmas, Matthew, et al. (author)
  • Evolutionary constraint and innovation across hundreds of placental mammals
  • 2023
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6643
  • Journal article (peer-reviewed)abstract
    • Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases (similar to 10.7%) in the human genome are unusually conserved across species (evolutionarily constrained) relative to neutrally evolving repeats, and 4552 ultraconserved elements are nearly perfectly conserved. Of 101 million significantly constrained single bases, 80% are outside protein-coding exons and half have no functional annotations in the Encyclopedia of DNA Elements (ENCODE) resource. Changes in genes and regulatory elements are associated with exceptional mammalian traits, such as hibernation, that could inform therapeutic development. Earth's vast and imperiled biodiversity offers distinctive power for identifying genetic variants that affect genome function and organismal phenotypes.
  •  
28.
  • Chu, Jiangtao, 1982-, et al. (author)
  • Influence of different pluronic surface modifications and pressure on microdialysis protein extraction efficiency
  • 2015
  • In: Biomedical microdevices (Print). - Springer. - 1387-2176 .- 1572-8781.
  • Journal article (peer-reviewed)abstract
    • There is growing interest in using microdialysis (MD) for monitoring larger and more complexmolecules such as neuropeptides and proteins. This promotes the use of MD membranes withmolecular weight cut off (MWCO) of 100 kDa. Hence, the hydrodynamic property of themembrane goes to ultrafiltration, making the sampling more sensitive to pressure changes. Also,despite the large membrane pore size, studies have shown that membrane biofouling still leads tounstable catheter performance. Our objective is to study in vitro how four kinds of surfacemodifications (Pluronic L31, L44, F87 and F127+L31) affect the fluid recovery (FR) andextraction efficiency (EE) of 100 kDa MWCO MD catheters, under controlled pressure. Apressure chamber was employed to facilitate the tests, using as MD sample a protein standardwith proteins of similar concentrations as in human cerebral spinal fluid. The collected dialysatefractions were examined for FR and EE. Targeted mass spectrometry analysed the EE ofindividual proteins and peptides. The thicker the pluronic adsorption layer, the less thehydrodynamic diameter of the membrane pores, leading to lower and more stable FR. The foursurface modifications had three different behaviours: Pluronic F127 + L31 showed similarbehavior to the Pluronic F127 and the native original membrane; Pluronic F87 showed acontinuous EE increase with pressure; Pluronic L31 and L44 showed similar EE values, whichwere stable with pressure. Different surface modifications are clearly selective to differentproteins and peptides. We conclude that a pluronic surface modification could provide MDsampling with more stable FR, and more stable or enhanced EE with high FR, depending on theobjective of the sampling.
  •  
29.
  • Chu, Jiangtao, 1982-, et al. (author)
  • Influence of surface modification and static pressure on microdialysis protein extraction efficiency
  • 2015
  • In: Biomedical microdevices (Print). - Springer : Springer Science and Business Media LLC. - 1387-2176 .- 1572-8781. ; 17:5
  • Journal article (peer-reviewed)abstract
    • There is growing interest in using microdialysis (MD) for monitoring larger and more complexmolecules such as neuropeptides and proteins. This promotes the use of MD membranes withmolecular weight cut off (MWCO) of 100 kDa or above. The hydrodynamic property of themembrane goes to ultrafiltration or beyond, making the MD catheters more sensitive to pressure.In the meantime, despite the large pore size, studies have shown that membrane biofouling stilllead to unstable catheter performance. The objective is to study in vitro how 500 kDa dextranand Poloxamer 407 surface modification affect the fluid recovery (FR) and extraction efficiency(EE) of 100 kDa MWCO MD catheters. A pressure chamber was designed to facilitate the tests,using as MD sample a protein standard with similar concentrations as in human cerebral spinalfluid, comparing native and Poloxamer 407 modified MD catheters. The collected dialysatefractions were examined for FR and protein EE, employing Dot-it Spot-it Protein Assay for totalprotein EE and targeted mass spectrometry (MS) for EE of individual proteins and peptides. TheFR results suggested that the surface modified catheters were less sensitive to the pressure andprovide higher precision, and provided a FR closer to 100%. The surface modification did notshow a significant effect on the protein EE. The average total protein EE of surface modifiedcatheters was slightly higher than that of the native ones. The MS EE data of individual proteinsshowed a clear trend of complex response in EE with pressure.
  •  
30.
  • Dahlgren, Andreas, et al. (author)
  • Association of the estrogen receptor 1 (ESR1) gene with body height in adult males from two Swedish population cohorts
  • 2008
  • In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 3:3, s. e1807-
  • Journal article (peer-reviewed)abstract
    • Human body height is a complex genetic trait with high heritability. We performed an association study of 17 candidate genes for height in the Uppsala Longitudinal Study of Adult Men (ULSAM) that consists of 1153 elderly men of age 70 born in the central region of Sweden. First we genotyped a panel of 137 single nucleotide polymorphism (SNPs) evenly distributed across the candidate genes in the ULSAM cohort. We identified 4 SNPs in the estrogen receptor gene (ESR1) on chromosome 6q25.1 with suggestive signals of association (p<0.05) with standing body height. This result was followed up by genotyping the same 25 SNPs in the ESR1 gene as in ULSAM in a second population cohort, the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort that consist of 507 males and 509 females of age 70 from the same geographical region as ULSAM. One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. No association was observed for the females in the PIVUS cohort.
  •  
31.
  •  
32.
  • Dimas, Antigone S, et al. (author)
  • Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
  • 2014
  • In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 63:6, s. 2158-2171
  • Journal article (peer-reviewed)abstract
    • Patients with established type 2 diabetes display both beta-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci and indices of proinsulin processing, insulin secretion and insulin sensitivity. We included data from up to 58,614 non-diabetic subjects with basal measures, and 17,327 with dynamic measures. We employed additive genetic models with adjustment for sex, age and BMI, followed by fixed-effects inverse variance meta-analyses. Cluster analyses grouped risk loci into five major categories based on their relationship to these continuous glycemic phenotypes. The first cluster (PPARG, KLF14, IRS1, GCKR) was characterized by primary effects on insulin sensitivity. The second (MTNR1B, GCK) featured risk alleles associated with reduced insulin secretion and fasting hyperglycemia. ARAP1 constituted a third cluster characterized by defects in insulin processing. A fourth cluster (including TCF7L2, SLC30A8, HHEX/IDE, CDKAL1, CDKN2A/2B) was defined by loci influencing insulin processing and secretion without detectable change in fasting glucose. The final group contained twenty risk loci with no clear-cut associations to continuous glycemic traits. By assembling extensive data on continuous glycemic traits, we have exposed the diverse mechanisms whereby type 2 diabetes risk variants impact disease predisposition.
  •  
33.
  • Dyrrdal, Anita Verpe, et al. (author)
  • Changes in design precipitation over the Nordic-Baltic region as given by convection-permitting climate simulations
  • 2023
  • In: Weather and Climate Extremes. - 2212-0947. ; 42
  • Journal article (peer-reviewed)abstract
    • The increased risk of flooding due to global warming and subsequent heavy rainfall events in the Nordic-Baltic region, call for recommendations directed at long-term planning. One example of such recommendations are climate change allowances. These are often based on expected changes in design precipitation as given by climate model simulations, and are used as a buffer on top of current design values to avoid a future increased damage potential as a consequence of climate change. We here compute expected changes in precipitation design values, so-called climate factors (CFs), for the Nordic-Baltic region, based on 3 km convection permitting simulations from the Nordic Convection Permitting Climate Projections project. These have the advantage of explicitly resolving convection, which has been shown to be the main contributor to increased rainfall. We assess the dependence of the CFs on rainfall duration, return period, and geographical location, focusing on the summer (convective) season, short durations and the high emission scenario RCP8.5. We also compare these CFs to those computed from a non-convection permitting regional climate model ensemble. We found higher CFs for the longer return period, with only few exceptions, and distinctly higher CFs going from daily to sub-daily durations. However, the different simulations give conflicting results for very short-duration rainfall (<3 h). The huge difference in the climate sensitivity of driving GCMs dominates the magnitude of estimated return levels. Our analysis is shaped by the high computational costs of running convection permitting models, resulting in a very limited ensemble (3 members) representing a single emission scenario (RCP8.5). Therefore, we believe that combining results from convection permitting simulations with a larger ensemble (21 members) of non-convection permitting simulations adds value to the assessment of robust climate change allowances for heavy precipitation in the Nordic-Baltic region.
  •  
34.
  • Eriksson, M., et al. (author)
  • 2R, 3S)-2,3-dibromosuccinic acid
  • 2006
  • In: Acta Crystallographica Section E. - : International Union of Crystallography (IUCr). - 1600-5368. ; 62, s. O200-O201
  • Journal article (peer-reviewed)abstract
    • Crystals of the title compound, C4H4Br2O4, were grown from an aqueous solution. The structure features centrosymmetric molecules, each of which forms hydrogen bonds with two adjacent acid molecules, yielding long chains.
  •  
35.
  • Faust, Robin, 1992, et al. (author)
  • Magnetic properties of ilmenite used for oxygen carrier aided combustion
  • 2023
  • In: Fuel. - : Elsevier BV. - 0016-2361. ; 340
  • Journal article (peer-reviewed)abstract
    • Oxygen carrier aided combustion is a combustion process that utilizes oxygen carrying particles in a fluidized bed to transport oxygen from oxygen-rich to oxygen-poor regions in the reactor. A commonly used oxygen-carrying material is ilmenite (FeTiO3) which is a naturally occurring mineral. At higher oxygen partial pressures ilmenite can react to pseudobrookite (Fe2TiO5) and thereby take up oxygen. Upon reduction of pseudobrookite in oxygen-lean locations the oxygen is released, which enhances the distribution of oxygen through the reactor. Ilmenite was used as bed material in an industrial 115 MWth circulating fluidized bed (CFB) boiler where recycled waste wood and wood chips were utilized as fuel. Bottom ash samples were extracted after one and two weeks and the samples were separated into two fractions by a magnetic separator. The magnetic fraction was expected to be enriched in iron-containing oxides and was therefore aimed to be recirculated into the boiler. The SEM-EDS analysis revealed that the non-magnetic fraction consists to the largest extent of feldspar (KAlSi3O8) particles. A significant amount of freshly introduced ilmenite particles was also classified as non-magnetic by the magnetic separator. Characteristic for these particles was a lack of ash layer, suggesting they had only recently been added to the system. In the magnetic fraction, several feldspar particles were found which were covered by a layer rich in Ca, Fe, Ti, and Si. Comparing the XRD analysis of the ash prior to magnetic separation with its magnetic fraction revealed a decrease of the peaks corresponding to feldspar. The removal of feldspar particles by magnetic separation was further corroborated by XRF analysis, where the concentration of K, Al and Si was significantly higher in the non-magnetic fraction, however, no changes were observed in the concentration of Fe. The present analyses shows that prolonged exposure time of ilmenite increases its magnetic susceptibility. Non-magnetic feldspar was shown to acquire significant magnetic susceptibility by formation of a surface layer containing Fe-rich attrition products from ilmenite.
  •  
36.
  • Faust, Robin, 1992, et al. (author)
  • Magnetic Properties of Ilmenite used for Oxygen Carrier Aided Combustion
  • 2022
  • Conference paper (other academic/artistic)abstract
    • Oxygen carrier aided combustion (OCAC) is a combustion process that utilizes oxygen carrying particles in a fluidized bed to transport oxygen from oxygen-rich (near the air inlet) to oxygen-poor (near the fuel inlet) regions in the reactor. A commonly used oxygen-carrying material is ilmenite (FeTiO3) which is a naturally occurring mineral. At higher oxygen partial pressures (oxygen-rich locations) ilmenite can react to pseudobrookite (Fe2TiO5) and thereby take up oxygen. Upon reduction of pseudobrookite in oxygen-lean locations the oxygen is released, which enhances the distribution of oxygen through the reactor. Ilmenite was used as bed material in an industrial 115 MWth circulating fluidized bed (CFB) boiler where recycled waste wood and wood chips were utilized as fuel. Bottom ash samples were extracted at different time intervals for a period of 14 days and subsequently separated into two fractions by a magnetic separator. The magnetic fraction was expected to be enriched in ilmenite, pseudobrookite and other iron-containing oxides and was therefore aimed to be recirculated into the boiler, while the non-magnetic fraction was considered as waste stream. In this study, the bottom ash samples as well as the two different ash fractions (magnetic and non-magnetic) were analysed with a scanning electron microscope (SEM) coupled with energy dispersive X-ray spectroscopy (EDS), an X-ray diffractometer (XRD), an X-ray fluorescence (XRF) spectrometer, and a magnetic susceptibility meter. The objective was to investigate the chemical and magnetic properties of the particles of each fraction. The SEM-EDS analysis revealed that the non-magnetic fraction consists to the largest extent of feldspar (KAlSi3O8) particles which are a common constituent of soil and minerals. A significant amount of freshly introduced ilmenite particles was also separated as non-magnetic and is therefore lost from the process. Characteristic for these particles was a lack of ash layer, suggesting they had recently been added to the system. In the magnetic fraction, several feldspar particles were found which were covered by a layer rich in Ca, Fe, Ti, and Si. Comparing the XRD analysis of the ash prior to magnetic separation with its magnetic fraction revealed a decrease of the peaks corresponding to feldspar. The peaks corresponding to CaTiO3 increase at later times of the experimental campaign, and they have a similar intensity in both magnetic fraction and total ash. The removal of feldspar particles by magnetic separation was further corroborated by XRF analysis, where the concentration of K, Al and Si was significantly higher in the non-magnetic fraction. The concentration of Ca increased in the ash and the magnetic fraction at later stages of the experiment. The present analyses provide valuable insight into the effect of wood ash on the chemical and magnetic properties of ilmenite during fluidized bed combustion. The efficiency of the magnetic separation is crucial for increasing the lifetime of the material and thereby decreasing cost and waste flows. Improvements in bed material handling could be further be applied for related processes such as chemical looping combustion.
  •  
37.
  • Figtree, G. A., et al. (author)
  • Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension
  • 2007
  • In: Journal of Steroid Biochemistry and Molecular Biology. - : Elsevier BV. - 0960-0760 .- 1879-1220. ; 103:2, s. 110-118
  • Journal article (peer-reviewed)abstract
    • Given the strong genetic contribution to blood pressure and left ventricular hypertrophy (LVH), and the influence of estrogen on these parameters, we hypothesized that polymorphisms in the estrogen receptor alpha (ERα) promoter may influence LVH. Three novel polymorphisms were identified upstream of the ERα alternatively spliced exon 1E, within sequence which demonstrated significant promoter activity in vitro. Demonstration of ERα E isoform expression in human ventricle by RT-PCR supported a possible functional role for the 1E novel polymorphisms in estrogen signaling in the heart. Indeed, G > A (-721 E) was significantly associated with LVH after controlling for systolic blood pressure and sex in a healthy population (n = 74), contributing to 23% of interventricular septum (IVS) width variance (p < 0.001) and 9.4% of left ventricular mass index (LVMI) variance (p = 0.035). In a separate hypertensive cohort, male carriers of the A allele (n = 8) had a 17% increase in IVS (95% CI: 6-28%) and a 19% increase in LVMI (3-34%) compared to GG homozygotes (n = 84). We conclude that a novel polymorphism in the promoter of a cardiac mRNA splice isoform of ERα is associated with LVH.
  •  
38.
  • Florén Lind, Sara, et al. (author)
  • Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior
  • 2023
  • In: Pharmacology, Biochemistry and Behavior. - 0091-3057 .- 1873-5177. ; 227-228
  • Journal article (peer-reviewed)abstract
    • Anxiety disorders are common psychiatric conditions with a partially elucidated neurobiology. Caffeine, an unspecific adenosine receptor antagonist, is a common psychostimulant with anxiogenic effects in sensitive individuals. High doses of caffeine produce anxiety-like behavior in rats but it is not known if this is specific for rats with high baseline anxiety-like behavior. Thus, the aim of this study was to investigate general behavior, risk-taking, and anxiety-like behavior, as well as mRNA expression (adenosine A2A and A1, dopamine D2, and, μ, κ, δ opioid, receptors, BDNF, c-fos, IGF-1) in amygdala, caudate putamen, frontal cortex, hippocampus, hypothalamus, after an acute dose of caffeine. Untreated rats were screened using the elevated plus maze (EPM), giving each rat a score on anxiety-like behavior based on their time spent in the open arms, and categorized into a high or low anxiety-like behavior group accordingly. Three weeks after categorization, the rats were treated with 50 mg/kg caffeine and their behavior profile was studied in the multivariate concentric square field (MCSF) test, and one week later in the EPM. qPCR was performed on selected genes and corticosterone plasma levels were measured using ELISA. The results demonstrated that the high anxiety-like behavior rats treated with caffeine spent less time in risk areas of the MCSF and resituated towards the sheltered areas, a behavior accompanied by lower mRNA expression of adenosine A2A receptors in caudate putamen and increased BDNF expression in hippocampus. These results support the hypothesis that caffeine affects individuals differently depending on their baseline anxiety-like behavior, possibly involving adenosine receptors. This highlights the importance of adenosine receptors as a possible drug target for anxiety disorders, although further research is needed to fully elucidate the neurobiological mechanisms of caffeine on anxiety disorders.
  •  
39.
  • Florén Lind, Sara, et al. (author)
  • Acute low dose caffeine affects behavior profile and activity, an examination of male rats with high or low anxiety-like behavior
  • 2023
  • In: Behavioural Brain Research. - : Elsevier. - 0166-4328 .- 1872-7549. ; 455
  • Journal article (peer-reviewed)abstract
    • Anxiety disorders affect up to one third of the population. Caffeine, an adenosine receptor antagonist, is thought to have a dose-dependent effect on anxiety. We recently showed that a high dose of caffeine (50 mg/kg) differentially affected anxiety-like behavior in rats with high or low baseline anxiety-like behavior, replicating findings using relatively high doses in human patient samples. It is not known if low doses of caffeine have similar effects. The elevated plus maze (EPM) was used to categorize male Wistar rats (13 weeks of age) into groups of high or low anxiety-like behavior. Behavior was evaluated using the multivariate concentric square field (MCSF) test and the EPM after a low 10 mg/kg dose of caffeine. Multivariate data analysis demonstrated that caffeine decreased the differences between the high and low anxiety group, whereas the separation remained for the high and low control groups. For the caffeine treated rats, univariate statistics showed an increase in parameters regarding activity in the EPM and duration in the slope of the MCSF. Regarding risk-taking, shelter-seeking, and exploratory behavior, caffeine did not affect the groups differently. In conclusion, these results demonstrate increased activity in the caffeine-treated rats, together with a potentially anxiolytic effect and increased impulsivity that did not differ between the baseline anxiety groups. In contrast to high caffeine doses, a low dose does not generally affect rats with high anxiety at baseline differently than rats with low anxiety-like behavior. Further studies are warranted to fully elucidate the effects of caffeine in anxiety.
  •  
40.
  • Franciosini, E., et al. (author)
  • The Gaia-ESO Survey : Lithium measurements and new curves of growth
  • 2022
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
  • Journal article (peer-reviewed)abstract
    • Context. The Gaia-ESO Survey (GES) is a large public spectroscopic survey that was carried out using the multi-object FLAMES spectrograph at the Very Large Telescope. The survey provides accurate radial velocities, stellar parameters, and elemental abundances for ~115 000 stars in all Milky Way components.Aims. In this paper, we describe the method adopted in the final data release to derive lithium equivalent widths (EWs) and abundances.Methods. Lithium EWs were measured using two different approaches for FGK and M-type stars, to account for the intrinsic differences in the spectra. For FGK stars, we fitted the lithium line using Gaussian components, while direct integration over a predefined interval was adopted for M-type stars. Care was taken to ensure continuity between the two regimes. Abundances were derived using a new set of homogeneous curves of growth that were derived specifically for GES, and which were measured on a synthetic spectral grid consistently with the way the EWs were measured. The derived abundances were validated by comparison with those measured by other analysis groups using different methods.Results. Lithium EWs were measured for ~40 000 stars, and abundances could be derived for ~38 000 of them. The vast majority of the measures (80%) have been obtained for stars in open cluster fields. The remaining objects are stars in globular clusters, or field stars in the Milky Way disc, bulge, and halo.Conclusions. The GES dataset of homogeneous lithium abundances described here will be valuable for our understanding of several processes, from stellar evolution and internal mixing in stars at different evolutionary stages to Galactic evolution.
  •  
41.
  • Franken, Matthias K., et al. (author)
  • Does passive sound attenuation affect responses to pitch-shifted auditory feedback?
  • 2019
  • In: The Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966. ; 146:6, s. 4108-4121
  • Journal article (peer-reviewed)abstract
    • The role of auditory feedback in vocal production has mainly been investigated by altered auditory feedback (AAF) in real time. In response, speakers compensate by shifting their speech output in the opposite direction. Current theory suggests this is caused by a mismatch between expected and observed feedback. A methodological issue is the difficulty to fully isolate the speaker’s hearing so that only AAF is presented to their ears. As a result, participants may be presented with two simultaneous signals. If this is true, an alternative explanation is that responses to AAF depend on the contrast between the manipulated and the non-manipulated feedback. This hypothesis was tested by varying the passive sound attenuation (PSA). Participants vocalized while auditory feed- back was unexpectedly pitch shifted. The feedback was played through three pairs of headphones with varying amounts of PSA. The participants’ responses were not affected by the different levels of PSA. This suggests that across all three headphones, PSA is either good enough to make the manipulated feedback dominant, or differences in PSA are too small to affect the contribution of non-manipulated feedback. Overall, the results suggest that it is important to realize that non-manipulated auditory feedback could affect responses to AAF.
  •  
42.
  • Franken, Matthias K., et al. (author)
  • Don’t blame yourself : Conscious source monitoring modulates feedback control during speech production
  • 2023
  • In: Quarterly Journal of Experimental Psychology. - : SAGE Publications. - 1747-0218 .- 1747-0226. ; 76:1, s. 15-27
  • Journal article (peer-reviewed)abstract
    • Sensory feedback plays an important role in speech motor control. One of the main sources of evidence for this is studies in which online auditory feedback is perturbed during ongoing speech. In motor control, it is therefore crucial to distinguish between sensory feedback and externally generated sensory events. This is called source monitoring. Previous altered feedback studies have taken non-conscious source monitoring for granted, as automatic responses to altered sensory feedback imply that the feedback changes are processed as self-caused. However, the role of conscious source monitoring is unclear. The current study investigated whether conscious source monitoring modulates responses to unexpected pitch changes in auditory feedback. During the first block, some participants spontaneously attributed the pitch shifts to themselves (self-blamers) while others attributed them to an external source (other-blamers). Before Block 2, all participants were informed that the pitch shifts were experimentally induced. The self-blamers then showed a reduction in response magnitude in Block 2 compared with Block 1, while the other-blamers did not. This suggests that conscious source monitoring modulates responses to altered auditory feedback, such that consciously ascribing feedback to oneself leads to larger compensation responses. These results can be accounted for within the dominant comparator framework, where conscious source monitoring could modulate the gain on sensory feedback. Alternatively, the results can be naturally explained from an inferential framework, where conscious knowledge may bias the priors in a Bayesian process to determine the most likely source of a sensory event.
  •  
43.
  • Franken, Matthias K., et al. (author)
  • Drifting pitch awareness after exposure to altered auditory feedback
  • 2022
  • In: Attention, Perception, and Psychophysics. - : Springer Science and Business Media LLC. - 1943-3921 .- 1943-393X. ; 84:6, s. 2027-2039
  • Journal article (peer-reviewed)abstract
    • Various studies have claimed that the sense of agency is based on a comparison between an internal estimate of an action’s outcome and sensory feedback. With respect to speech, this presumes that speakers have a stable prearticulatory representation of their own speech. However, recent research suggests that the sense of agency is flexible and thus in some contexts we may feel like we produced speech that was not actually produced by us. The current study tested whether the estimated pitch of one’s articulation (termed pitch awareness) is affected by manipulated auditory feedback. In four experiments, 56 participants produced isolated vowels while being exposed to pitch-shifted auditory feedback. After every vocalization, participants indicated whether they thought the feedback was higher or lower than their actual production. After exposure to a block of high-pitched auditory feedback (+500 cents pitch shift), participants were more likely to label subsequent auditory feedback as “lower than my actual production,” suggesting that prolonged exposure to high-pitched auditory feedback led to a drift in participants’ pitch awareness. The opposite pattern was found after exposure to a constant −500 cents pitch shift. This suggests that pitch awareness is not solely based on a prearticulatory representation of intended speech or on a sensory prediction, but also on sensory feedback. We propose that this drift in pitch awareness could be indicative of a sense of agency over the pitch-shifted auditory feedback in the exposure block. If so, this suggests that the sense of agency over vocal output is flexible.
  •  
44.
  •  
45.
  •  
46.
  • Frazier-Wood, Alexis C., et al. (author)
  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
  • 2016
  • In: Nature Genetics. - : Nature Research (part of Springer Nature). - 1061-4036 .- 1546-1718. ; 48, s. 624-
  • Journal article (peer-reviewed)abstract
    • Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
  •  
47.
  • Friel, E. D., et al. (author)
  • Gaia-ESO Survey : Properties of the intermediate age open cluster NGC 4815
  • 2014
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 563, s. A117-
  • Journal article (peer-reviewed)abstract
    • Context. NGC 4815 is a populous similar to 500 Myr open cluster at R-gc similar to 7 kpc observed in the first six months of the Gaia-ESO Survey. Located in the inner Galactic disk, NGC 4815 is an important potential tracer of the abundance gradient, where relatively few intermediate age open clusters are found. Aims. The Gaia-ESO Survey data can provide an improved characterization of the cluster properties, such as age, distance, reddening, and abundance profile. Methods. We use the survey derived radial velocities, stellar atmospheric parameters, metallicity, and elemental abundances for stars targeted as potential members of this cluster to carry out an analysis of cluster properties. The radial velocity distribution of stars in the cluster field is used to define the cluster systemic velocity and derive likely cluster membership for stars observed by the Gaia-ESO Survey. We investigate the distributions of Fe and Fe-peak elements, alpha-elements, and the light elements Na and Al and characterize the cluster's internal chemical homogeneity comparing it to the properties of radial velocity non-member stars. Utilizing these cluster properties, the cluster color-magnitude diagram is analyzed and theoretical isochrones are fit to derive cluster reddening, distance, and age. Results. NGC 4815 is found to have a mean metallicity of [Fe/H] = +0.03 +/- 0.05 dex (s.d.). Elemental abundances of cluster members show typically very small internal variation, with internal dispersions of similar to 0.05 dex. The alpha-elements [Ca/Fe] and [Si/Fe] show solar ratios, but [Mg/Fe] is moderately enhanced, while [Ti/Fe] appears slightly deficient. As with many open clusters, the light elements [Na/Fe] and [Al/Fe] are enhanced, [Na/Fe] significantly so, although the role of internal mixing and the assumption of local thermodynamical equilibrium in the analysis remain to be investigated. From isochrone fits to color-magnitude diagrams, we find a cluster age of 0.5 to 0.63 Gyr, a reddening of E(B-V) = 0.59 to 0.65, and a distance modulus (m -M)(0) = 11.95 to 12.20, depending on the choice of theoretical models, leading to a Galactocentric distance of 6.9 kpc.
  •  
48.
  • Fu, X., et al. (author)
  • The Gaia-ESO Survey : Lithium enrichment histories of the Galactic thick and thin disc
  • 2018
  • In: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 610
  • Journal article (peer-reviewed)abstract
    • Lithium abundance in most of the warm metal-poor main sequence stars shows a constarnt plateau (A(Li) similar to 2.2 dex) and then the upper envelope of the lithium vs. metallicity distribution increases as we approach solar metallicity. Meteorites, which carry information about the chemical composition of the interstellar medium (ISM) at the solar system formation time, show a lithium abundance A(Li) similar to 3.26 dex. This pattern reflects the Li enrichment history of the ISM during the Galaxy lifetime. After the initial Li production in big bang nucleosynthesis, the sources of the enrichment include asymptotic giant branch (AGB) stars, low-mass red giants, novae, type II supernovae, and Galactic cosmic rays. The total amount of enriched Li is sensitive to the relative contribution of these sources. Thus different Li enrichment histories are expected in the Galactic thick and thin disc. We investigate the main sequence stars observed with UVES in Gaia-ESO Survey iDR4 catalogue and find a Li[alpha/Fe] anticorrelation independent of [Fe/H], T-eff, and log(g). Since in stellar evolution different alpha enhancements at the same metallicity do not lead to a measurable Li abundance change, the anticorrelation indicates that more Li is produced during the Galactic thin disc phase than during the Galactic thick disc phase. We also find a correlation between the abundance of Li and s-process elements Ba and Y, and they both decrease above the solar metallicity, which can be explained in the framework of the adopted Galactic chemical evolution models.
  •  
49.
  • Fugmann, Andreas, et al. (author)
  • Blood flow is an important determinant of forearm glucose uptake following a mixed meal
  • 2003
  • In: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 40:3, s. 113-117
  • Journal article (peer-reviewed)abstract
    • Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p<0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p<0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p<0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p<0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p<0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.
  •  
50.
  • Fugmann, Andreas, et al. (author)
  • Central and peripheral haemodynamic effects of hyperglycaemia, hyperinsulinaemia, hyperlipidaemia or a mixed meal
  • 2003
  • In: Clinical Science. - 0143-5221 .- 1470-8736. ; 105:6, s. 715-721
  • Journal article (peer-reviewed)abstract
    • The aim of the present study was to evaluate the haemodynamic changes during hyperinsulinaemia, hyperglycaemia or hypertriglyceridaemia in relation to those following a mixed meal. Ten subjects were subjected to hypertriglyceridaemia (3.9 mmol/l) for 2 h by an infusion of Intralipid and heparin. Nine subjects received a hyperglycaemic clamp (12.5 mmol/l) with octreotide and low-dose insulin infusion to maintain normoinsulinaemia (10 m-units/l). Ten subjects received saline for 2 h as a control and, thereafter, 2 h of normoglycaemic hyperinsulinaemic clamp (80 m-units/l). Finally, ten subjects were evaluated for 2 h following an ordinary mixed meal. Calf blood flow was measured by venous occlusion plethysmography and cardiac index by thoracic bioimpedance. Both the mixed meal and normoglycaemic hyperinsulinaemia lowered total peripheral resistance, and increased calf blood flow and cardiac index, whereas blood pressure decreased (P <0.05-0.001). Both hyperglycaemia and hypertriglyceridaemia increased calf blood flow, but blood pressure was unchanged. Total peripheral resistance was unchanged in hypertriglyceridaemia, whereas hyperglycaemia induced a significant increase. Normoglycaemic hyperinsulinaemia induced a haemodynamic pattern similar, but to a lesser extent, to the pattern seen following a mixed meal. Hyperinsulinaemia seems to be a major mediator of the haemodynamic response, but other factors are obviously also of great importance. Hypertriglyceridaemia and hyperglycaemia induced haemodynamic responses that are not similar to those seen following a mixed meal.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-50 of 209
Type of publication
journal article (162)
conference paper (17)
doctoral thesis (10)
other publication (6)
reports (5)
research review (3)
show more...
licentiate thesis (3)
book (2)
artistic work (1)
book chapter (1)
show less...
Type of content
peer-reviewed (170)
other academic/artistic (37)
pop. science, debate, etc. (2)
Author/Editor
Lind, Lars (50)
Lind, Karin (22)
Lind, Andreas (22)
Randich, S. (21)
Jofré, P. (21)
Morbidelli, L. (20)
show more...
Smiljanic, R. (19)
Gilmore, G. (19)
Magrini, L. (19)
Zaggia, S. (18)
Bragaglia, A. (18)
de laverny, P. (17)
Feltzing, Sofia (17)
Heiter, Ulrike (17)
Worley, C. C. (17)
Pancino, E. (17)
Hourihane, A. (17)
Recio-Blanco, A. (16)
Bensby, Thomas (16)
Terent, Andreas (16)
Vallenari, A. (16)
Lardo, C. (16)
Asplund, M. (15)
Franciosini, E. (15)
Carraro, G. (15)
Bergemann, M. (15)
Damiani, F. (14)
Prisinzano, L. (14)
Monaco, L (13)
Hill, V. (13)
Flaccomio, E. (13)
Johansson, Petter (12)
Hall, Lars (12)
Costado, M. T. (12)
Sbordone, L. (12)
Bayo, A. (12)
Sacco, G. G. (12)
Masseron, T. (12)
Lewis, J (11)
Berne, Christian (11)
Frasca, A. (11)
Lanzafame, A. C. (11)
Koposov, S. E. (11)
Korn, Andreas J. (11)
Fugmann, Andreas (11)
Lithell, Hans (10)
Francois, P. (10)
Tautvaisiene, G. (10)
Jeffries, R. D. (10)
Lind, K (10)
show less...
University
Uppsala University (123)
Lund University (68)
Karolinska Institutet (30)
University of Gothenburg (15)
Stockholm University (13)
Mid Sweden University (11)
show more...
Umeå University (10)
University of Skövde (9)
Royal Institute of Technology (8)
Linköping University (5)
Chalmers University of Technology (5)
Högskolan Dalarna (5)
Malmö University (4)
University of Gävle (3)
Örebro University (3)
VTI - The Swedish National Road and Transport Research Institute (3)
Kristianstad University College (2)
Stockholm School of Economics (2)
RISE (2)
Karlstad University (2)
Nationalmuseum (1)
Luleå University of Technology (1)
Halmstad University (1)
Jönköping University (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (192)
Swedish (9)
Undefined language (8)
Research subject (UKÄ/SCB)
Natural sciences (74)
Medical and Health Sciences (53)
Engineering and Technology (27)
Humanities (15)
Social Sciences (14)
Agricultural Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view