| 1. |
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| 2. |
- Andersson, Per Ola, et al.
(author)
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A novel ATR-FTIR method for functionalised surface characterisation
- 2008
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In: Surface and Interface Analysis. - : Wiley. - 0142-2421 .- 1096-9918. ; 40:3-4, s. 623-626
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Journal article (peer-reviewed)abstract
- We demonstrate a novel method to analyse ex situ prepared chips by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), which circumvents tedious functionalisation steps of internal reflection elements (IREs), and simultaneously allows for complementary measurements by other analytical techniques. This concept is proved by utilising immobilised metal affinity capture (IMAC) chips containing about 10 gm thick films of copolymers coated with nitrilotriacetic acid (NTA) groups. With this so-called 'upside-down' ATR-FTIR technique, each chemical modification step can be followed and optimised with respect to concentration, buffer, pH, ionic strength, and so on, and there are no limitations in variations or numbers of functionalised surfaces that can be generated. We have demonstrated the feasibility of this approach to determine the molecular structure of ligand bonded to immobilised polypeptide, directly observed in the raw ATR-FTIR spectrum. Peptide adsorption in a thick NTA-copolymer matrix yields a high peptide concentration as determined by the analysis of the Langmuir adsorption isotherm. Combined with the 'upside-down' ATR-FTIR approach which samples the outermost region of the exposed NTA-copolymer film, this generates well-resolved amide I and II absorption bands that reduce the necessity of using D2O based buffers, which otherwise is common in mid-IR spectroscopy of proteins. We believe that this new optical surface characterisation method has a great potential as a stand-alone or complementary analytical tool. We emphasise further that with this approach no chemical treatment of IREs is needed; the chips can be regenerated and reused, and analysed by complementary analytical techniques such as mass spectrometry.
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| 3. |
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| 4. |
- Ax, Erika, et al.
(author)
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Circulating levels of environmental contaminants are associated with dietary patterns in older adults
- 2015
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In: Environment International. - Oxford, United Kingdom : Elsevier. - 0160-4120 .- 1873-6750. ; 75, s. 93-102
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Journal article (peer-reviewed)abstract
- Background: Food intake contributes substantially to our exposure to environmental contaminants. Still, little is known about our dietary habits' contribution to exposure variability.Objective: The aim of this study was to assess circulating levels of environmental contaminants in relation to predefined dietary patterns in an elderly Swedish population.Methods: Dietary data and serum concentrations of environmental contaminants were obtained from 844 70-year-old Swedish subjects (50% women) in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Dietary data from 7-day food records was used to assess adherence to a Mediterranean-like diet, a low carbohydrate-high protein diet and the WHO dietary recommendations. Circulating levels of 6 polychlorinated biphenyl markers, 3 organochlorine pesticides, 1 dioxin and 1 polybrominated diphenyl ether, the metals cadmium, lead, mercury and aluminum and serum levels of bisphenol A and 4 phthalate metabolites were investigated in relation to dietary patterns in multivariate linear regression models.Results: A Mediterranean-like diet was positively associated with levels of several polychlorinated biphenyls (118, 126, 153, and 209), trans-nonachlor and mercury. A low carbohydrate-high protein diet was positively associated with polychlorinated biphenyls 118 and 153, trans-nonachlor, hexachlorobenzene and p, p'-dichlorodiphenyldichloroethylene, mercury and lead. The WHO recommended diet was negatively related to levels of dioxin and lead, and borderline positively to polychlorinated biphenyl 118 and trans-nonachlor.Conclusion: Dietary patterns were associated in diverse manners with circulating levels of environmental contaminants in this elderly Swedish population. Following the WHO dietary recommendations seems to be associated with a lower burden of environmental contaminants.
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| 5. |
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| 6. |
- Bixby, H., et al.
(author)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Journal article (peer-reviewed)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 7. |
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| 8. |
- Ekberg, Niclas, et al.
(author)
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Projekt: Pekplattan som resurs – ett pedagogiskt verktyg för lärare och lärande
- 2014
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Other publication (pop. science, debate, etc.)abstract
- Sammanfattning: Projektet syftar till att utforska pekplattans pedagogiska möjligheter och utveckla metoder som berikar undervisningen och lärandet. Vi avser använda pekplattan för kommunikation och interaktion, för pedagogiska framställningar, som organisatoriskt stöd för studenten i dennes studier och som del i lärarens dagliga administrativa arbete. Vi ämnar även utveckla metoder för att bättre tillvarata lärandets multimodala aspekter, dvs. att med utgångspunkt i olika kombinationer av bild, film, ljud och skriven text finna nya vägar till kunskapsrepresentation och reflektion. Projektet bidrar således till en flexiblare lärmiljö, högre kvalitet i undervisningen samt till studentens engagemang och självständighet att själv göra, äga och visa. Utvecklingsprojektet fokuserar förskollärarprogrammets lärare och studenter, med dess profilering mot naturvetenskap och teknik, och i förlängningen studentens professionalitet i yrkesrollen. Resultaten blir dock högst relevanta för lärare och studenter på LTU:s övriga utbildningar. Resultatspridning sker genom projektrapport, anordnande av öppna seminarier och i våra pedagogiska nätverk inom och utom universitetet. Projektet beviljades medel av dels IT-beredningen, LTU, december 2013, uppgående till 200TKr och dels Pedagogisk utvecklingsfond, Luleå tekniska universitet, maj 2014 (omgång 3) uppgående till 440TKr
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| 9. |
- Eriksson, Jan W., et al.
(author)
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Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study
- 2018
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 61:9, s. 1923-1934
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Journal article (peer-reviewed)abstract
- Aims/hypothesis The EFFECT-II study aimed to investigate the effects of dapagliflozin and omega-3 (n-3) carboxylic acids (OM-3CA). individually or combined, on liver fat content in individuals with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Methods This randomised placebo-controlled double-blind parallel-group study was performed at five clinical research centres at university hospitals in Sweden. 84 participants with type 2 diabetes and NAFLD were randomly assigned 1:1:1:1 to four treatments by a centralised randomisation system, and all participants as well as investigators and staff involved in the study conduct and analyses were blinded to treatments. Each group received oral doses of one of the following: 10 mg dapagliflozin (n = 21). 4 g OM3-CA (n = 20), a combination of both (n = 22) or placebo (n = 21). The primary endpoint was liver fat content assessed by MRI (proton density fat fraction [PDFF]) and, in addition, total liver volume and markers of glucose and lipid metabolism as well as of hepatocyte injury and oxidative stress were assessed at baseline and after 12 weeks of treatment (completion of the trial). Results Participants had a mean age of 65.5 years (SD 5.9), BMI 31.2 kg/m(2) (3.5) and liver PDFF 18% (9.3). All active treatments significantly reduced liver PDFF from baseline, relative changes: OM-3CA, -15%; dapagliflozin, -13%; OM-3CA + dapagliflozin, -21%. Only the combination treatment reduced liver PDFF (p = 0.046) and total liver fat volume (relative change, -24%,p = 0.037) in comparison with placebo. There was an interaction between the PNPLA31148M polymorphism and change in liver PDFF in the active treatment groups (p = 0.03). Dapagliflozin monotherapy, but not the combination with OM-3CA, reduced the levels of hepatocyte injury biomarkers, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transfcrase (gamma-GT), cytokeratin (CK) 18-M30 and CK 18-M65 and plasma fibroblast growth factor 21 (FGF21). Changes in gamma-GT correlated with changes in liver PDFF (rho = 0.53, p = 0.02). Dapagliflozin alone and in combination with OM-3CA improved glucose control and reduced body weight and abdominal fat volumes. Fatty acid oxidative stress biomarkers were not affected by treatments. There were no new or unexpected adverse events compared with previous studies with these treatments. Conclusions/interpretation Combined treatment with dapagliflozin and OM-3CA significantly reduced liver fat content. Dapagliflozin monotherapy reduced all measured hepatocyte injury biomarkers and FGF21, suggesting a disease-modifying effect in NAFLD.
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| 10. |
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| 11. |
- Fryk, Emanuel, et al.
(author)
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Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study
- 2021
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In: Ebiomedicine. - : Elsevier BV. - 2352-3964. ; 65
-
Journal article (peer-reviewed)abstract
- Background: It is commonly accepted that in obesity free fatty acids (FFA) cause insulin resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia is observed in subjects with normoglycaemia and thus the paradigm above should be reevaluated. Methods: We describe two studies: MD-Lipolysis, a case control study investigating the mechanisms of obesity-driven insulin resistance by a systemic metabolic analysis, measurements of adipose tissue lipolysis by microdialysis, and adipose tissue genomics; and POEM, a cohort study used for validating differences in circulating metabolites in relation to adiposity and insulin resistance observed in the MD-Lipolysis study. Findings: In insulin-resistant obese with normal glycaemia from the MD-Lipolysis study, hyperinsulinemia was associated with elevated FFA. Lipolysis, assessed by glycerol release per adipose tissue mass or adipocyte surface, was similar between obese and lean individuals. Adipose tissue from obese subjects showed reduced expression of genes mediating catecholamine-driven lipolysis, lipid storage, and increased expression of genes driving hyperplastic growth. In the POEM study, FFA levels were specifically elevated in obese-overweight subjects with normal fasting glucose and high fasting levels of insulin and C-peptide. Interpretation: In obese subjects with normal glycaemia elevated circulating levels of FFA at fasting are the major metabolic derangement candidate driving fasting hyperinsulinemia. Elevated FFA in obese with normal glycaemia were better explained by increased fat mass rather than by adipose tissue insulin resistance. These results support the idea that hyperinsulinemia and insulin resistance may develop as part of a homeostatic adaptive response to increased adiposity and FFA. (C) 2021 The Author(s). Published by Elsevier B.V.
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| 12. |
- Huttunen, Henri J., et al.
(author)
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Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial
- 2023
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In: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257. ; 38:7, s. 1209-1222
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Journal article (peer-reviewed)abstract
- Background: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD). Objective: The primary objectives of this study were to assess the safety and tolerability of both CDNF and the drug delivery system (DDS) in patients with PD of moderate severity. Methods: We assessed the safety and tolerability of monthly intraputamenal CDNF infusions in patients with PD using an investigational DDS, a bone-anchored transcutaneous port connected to four catheters. This phase 1 trial was divided into a placebo-controlled, double-blind, 6-month main study followed by an active-treatment 6-month extension. Eligible patients, aged 35 to 75 years, had moderate idiopathic PD for 5 to 15 years and Hoehn and Yahr score ≤ 3 (off state). Seventeen patients were randomized to placebo (n = 6), 0.4 mg CDNF (n = 6), or 1.2 mg CDNF (n = 5). The primary endpoints were safety and tolerability of CDNF and DDS and catheter implantation accuracy. Secondary endpoints were measures of PD symptoms, including Unified Parkinson's Disease Rating Scale, and DDS patency and port stability. Exploratory endpoints included motor symptom assessment (PKG, Global Kinetics Pty Ltd, Melbourne, Australia) and positron emission tomography using dopamine transporter radioligand [18F]FE-PE2I. Results: Drug-related adverse events were mild to moderate with no difference between placebo and treatment groups. No severe adverse events were associated with the drug, and device delivery accuracy met specification. The severe adverse events recorded were associated with the infusion procedure and did not reoccur after procedural modification. There were no significant changes between placebo and CDNF treatment groups in secondary endpoints between baseline and the end of the main and extension studies. Conclusions: Intraputamenally administered CDNF was safe and well tolerated, and possible signs of biological response to the drug were observed in individual patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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| 13. |
- Lind, Mikael, et al.
(author)
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Service and Communication Infrastructure for Sea Traffic Management
- 2015
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In: 14th International Conference on Computer Applications and Information Technology in the Maritime Industries. ; , s. 290-305
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Conference paper (peer-reviewed)abstract
- The introduction of Sea Traffic Management services relies on infrastructures that enable trustworthy information sharing and service provisioning/consumption processes. For this purpose, a federated and regulated approach to information sharing and service distribution is proposed. Such an approach would position the governance of different services in the continuum of hierarchical (i.e.command and control) to market-driven approaches. In this paper the maritime infrastructure framework is presented and applied to Sea Traffic Management. The full potential and large-scale implementation would come when the same framework is applied in different areas of application that rely on information sharing, service interaction, and (digitized) actor collaboration.
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| 14. |
- Locke, Adam E, et al.
(author)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Journal article (peer-reviewed)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 15. |
- Lu, Jun, 1962-, et al.
(author)
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Tin+1Cn MXenes with fully saturated and thermally stable Cl terminations
- 2019
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In: Nanoscale Advances. - : Royal Society of Chemistry. - 2516-0230. ; 1:9, s. 3680-3685
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Journal article (peer-reviewed)abstract
- MXenes are a rapidly growing family of 2D materials that exhibit a highly versatile structure and composition, allowing for significant tuning of the materials properties. These properties are, however, ultimately limited by the surface terminations, which are typically a mixture of species, including F and O that are inherent to the MXene processing. Other and robust terminations are lacking. Here, we apply high-resolution scanning transmission electron microscopy (STEM), corresponding image simulations and first-principles calculations to investigate the surface terminations on MXenes synthesized from MAX phases through Lewis acidic melts. The results show that atomic Cl terminates the synthesized MXenes, with mere residual presence of other termination species. Furthermore, in situ STEM-electron energy loss spectroscopy (EELS) heating experiments show that the Cl terminations are stable up to 750 degrees C. Thus, we present an attractive new termination that widely expands the MXenes functionalization space and enables new applications.
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| 16. |
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| 17. |
- Paul-Visse, Gesine, et al.
(author)
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Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
- 2015
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In: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 125:3, s. 1339-1346
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Journal article (peer-reviewed)abstract
- BACKGROUND. Recombinant human PDGF-BB (rhPDGF-BB) reduces Parkinsonian symptoms and increases dopamine transporter (DAT) binding in several animal models of Parkinson's disease (PD). Effects of rhPDGF-BB are the result of proliferation of ventricular wall progenitor cells and reversed by blocking mitosis. Based on these restorative effects, we assessed the safety and tolerability of intracerebroventricular (i.c.v.) rhPDGF-BB administration in individuals with PD. METHODS. We conducted a double-blind, randomized, placebo-controlled phase I/IIa study at two clinical centers in Sweden. Twelve patients with moderate PD received rhPDGF-BB via an implanted drug infusion pump and an investigational i.c.v. catheter. Patients were assigned to a dose cohort (0.2, 1.5, or 5 mu g rhPDGF-BB per day) and then randomized to active treatment or placebo (3:1) for a 12-day treatment period. The primary objective was to assess safety and tolerability of i.c.v.-delivered rhPDGF-BB. Secondary outcome assessments included several clinical rating scales and changes in DAT binding. The follow-up period was 85 days. RESULTS. All patients completed the study. There were no unresolved adverse events. Serious adverse events occurred in three patients; however, these were unrelated to rhPDGF-BB administration. Secondary outcome parameters did not show dose-dependent changes in clinical rating scales, but there was a positive effect on DAT binding in the right putamen. CONCLUSION. At all doses tested, i.c.v. administration of rhPDGF-BB was well tolerated. Results support further clinical development of rhPDGF-BB for patients with PD.
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| 18. |
- Penell, Johanna, et al.
(author)
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Genetic variation in the CYP2B6 Gene is related to circulating 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) concentrations : an observational population-based study
- 2014
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In: Environmental Health. - London : BioMed Central (BMC). - 1476-069X. ; 13, s. 34-
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Journal article (peer-reviewed)abstract
- Background: Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample.Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (men and women all aged 70), 25 single nucleotide polymorphisms (SNPs) in the CYP2B6 gene were genotyped. Circulating concentrations of BDE-47 were analyzed by high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS).Results: Several SNPs in the CYP2B6 gene were associated with circulating concentrations of BDE-47 (P = 10(- 4) to 10(-9)). The investigated SNPs came primarily from two haplotypes, although the correlation between the haplotypes was rather high. Conditional analyses adjusting for the SNP with the strongest association with the exposure (rs2014141) did not provide evidence for independent signals.Conclusion: Circulating concentrations of BDE-47 were related to genetic variation in the CYP2B6 gene in an elderly population.
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| 19. |
- Sjögren, Per, et al.
(author)
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Circulating levels of perfluoroalkyl substances are associated with dietary patterns : A cross sectional study in elderly Swedish men and women
- 2016
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In: Environmental Research. - San Diego, USA : Academic Press. - 0013-9351 .- 1096-0953. ; 150, s. 59-65
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Journal article (peer-reviewed)abstract
- Background: In our daily life, we are exposed to perfluoroalkyl substances (PFAS) with possible health implications. The main exposure route for these substances is diet but comparative studies on how dietary habits influence exposure are lacking.Objectives: To examine the relations between blood levels of PFAS and adherence to three predefined dietary patterns (a WHO recommended diet, a Mediterranean-like diet, and a Low-Carbohydrate High-Protein (LCHP) diet) in an elderly Swedish population.Methods: Dietary data from 7-day food records and serum concentrations of PFAS were obtained from a 70-year-old Swedish population (n=844), the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. The Healthy Diet Indicator score (based on WHO recommendations), the Mediterranean Diet Score and LCHP score were used to assess adherence. Multivariate linear regression was used to assess the associations between eight major PFAS and adherence to each dietary pattern.Results: The WHO recommended diet was positively associated with perfluorohexane sulfonic acid (PFHxS). The LCHP diet was positively related to four out of eight PFAS; namely, perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnDA). The Mediterranean-like diet was positively associated with most PFAS; namely perfluorooctanoic acid (PFOA), perfluorooctane sulfonamide (PFOSA), PFHxS, PFNA, PFDA, and PFUnDA.Conclusions: All dietary patterns were positively associated with blood levels of PFAS. The highest body burden of PFAS was found in individuals with high adherence to a Mediterranean-like diet, whilst individuals who more closely followed the officially recommended diet displayed a lower body burden of these compounds.
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| 20. |
- Sundström, Johan, Professor, 1971-, et al.
(author)
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Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults
- 2019
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In: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 48:6, s. 2018-2025
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Journal article (peer-reviewed)abstract
- BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium.METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries.RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH.CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives.
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| 21. |
- T. Tegler, Lotta, et al.
(author)
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A highly selective polypeptide binder for human Acetylcholine esterase
-
Other publication (other academic/artistic)abstract
- A highly selective high-affinity polypeptide conjugate binder for human Acetylcholine Esterase (hAChE) has been obtained by coupling a derivative of acridine, a known medium-affinity inhibitor of hAChE, to each member of a 16-membered set of 42-residue polypeptide scaffolds. The best candidate, 4-C10L17-Ac, was identified to have a KD of 10 nM or less in an assay where each polypeptide conjugate was titrated with hAChE in 50 mM phosphate buffer at pH 7.0 and 298K. It was found in a sandwich ELISA to have high selectivity for hAChE in cerebrospinal fluid. Targeting the active site of hAChE by a polypeptide conjugate binder presents a special problem as it is buried deep inside the protein in a cavity that is approximately 20 Å deep. In order to permit simultaneous and cooperative binding of the acridine and the polypeptide to the active site and the AChE surface a fourteen atom spacer was needed. The 9-aminoacridine group was linked to the side chain of a lysine residue in each polypeptide via a spacer prepared from two aminohexanoic acid fragments. The results reinforce the impression that polypeptide conjugates are excellent alternatives to currently used protein binder technologies in diagnostic and therapeutic applications and that the conjugation of enzyme inhibitors to polypeptide scaffolds is a strategy of general applicability in the design of high-affinity binders for enzymes.
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| 22. |
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| 23. |
- Ahlgren, Per Christian, et al.
(author)
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Deals and value measuring in interactive health-care services
- 2023
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In: Journal of Business and Industrial Marketing. - : Emerald Group Publishing Limited. - 2052-1189 .- 0885-8624. ; 38:6, s. 1266-1278
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Journal article (peer-reviewed)abstract
- Purpose This paper aims to investigate the role of value measuring (VM) as an integrated part of a deal introduced to govern the cross-boundary relationship of state specialist- and primary care providers in the Norwegian health sector. Design/methodology/approach Drawing on a longitudinal ethnographic case study, this study explores the role of payment for dischargeable patients (PDP), an incentive arrangement introduced as a mechanism of value appropriation intended to create stability in the relationship and support improved patient flows between care providers. The fieldwork took place over approximately 18 months, consisting of intensive participant observations, interviews and document studies. Findings The VM integrated in the PDP deal between the hospital and municipality, on the surface level, appears simple. The VM, however, rests on a very complex practice of information sharing where accounts on patient status, procedures and activities form the basis of the integrated VM. The deal and its VM, despite its ambitious aims, were not able to fulfill the expectations of a smooth appropriation of value through the management of monetary flows or supporting information sharing for value creation. The VM of the PDP deal aimed at bringing the parties closer together, rather created a distance where money matters became a source of tension. Originality/value This study investigates the interconnections of deals and VM in a public sector service context, showing aspects of deals different from that of prior studies into private sector deals.
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| 24. |
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| 25. |
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| 26. |
- Ahlgren, Per Christian, et al.
(author)
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The Nordic research on accounting in inter-organizational relationships - the foundations of a microprocessual research approach to classical issues
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In: Journal of Accounting and Organizational Change. - 1839-5473 .- 1832-5912. ; 19:1, s. 115-141
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Journal article (peer-reviewed)abstract
- Purpose The purpose of this paper is to review the Nordic research on accounting in inter-organizational relationships (IORs) and relates the Nordic contributions to the international literature. Additionally, it examines alternative approaches to the understanding of accounting in IORs and proposes some directions for future research. Design/methodology/approach Thirty-one papers were identified and assessed in terms of their topic, inter-organizational setting, theoretical approach, research methods and results. This study followed a six-step process from formulating objectives, through establishing inclusion and exclusion criteria, to paper selection and mutual assessments. Findings The Nordic literature presents a distinct approach to the understanding of accounting in IORs. The Nordic studies are characterized by theoretical pluralism, in-depth case studies and an interest towards micro-processes in a variety of inter-organizational settings and from the point of view of multiple parties. Originality/value The authors propose two specific areas of research: the interconnections between accounting measures, monetary flows and value creation as well as the role of accounting in creating stability and instability in IORs. These areas of research emphasize a stronger engagement with the core issues of managing appropriation and cooperation concerns and provide an outlook for novel insights into classical issues and increased integration within the field.
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| 27. |
- Ahlström, Tommy, et al.
(author)
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Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women
- 2009
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In: Clinical Endocrinology. - : Wiley. - 0300-0664 .- 1365-2265. ; 71:5, s. 673-678
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Journal article (peer-reviewed)abstract
- CONTEXT: In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormone (PTH) and the variables in the MetS in a normal population are still unclear.OBJECTIVE: To describe correlations between plasma calcium and PTH and the various abnormalities present in the MetS in a healthy population.DESIGN: We studied 1016 healthy individuals from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) population of 70 years old, by means of plasma analyses of calcium, PTH, creatinine, lipids, insulin and glucose, as well as by standardized blood pressure measurements. Further, body mass index (BMI) and waist circumference were determined.RESULTS: The more National Cholesterol Education Program (NCEP) criteria for the MetS that were met, the higher the s-PTH and albumin-corrected s-calcium. Further, positive correlations between plasma calcium and BMI (P = 0.0003), waist circumference (P = 0.0009) and insulin resistance (P = 0.079) were found. PTH and BMI (P < 0.0001), waist circumference (P < 0.0001), systolic blood pressure (P = 0.0034), diastolic blood pressure (P = 0.0008), serum triglycerides (P = 0.0003) and insulin resistance (P = 0.0003) were positively correlated, whereas serum high density lipoproteins (HDL) (P = 0.036) and PTH were negatively correlated.CONCLUSIONS: We conclude that PTH correlates with several of the metabolic factors included in the MetS within a normocalcaemic population. In addition, individuals with mild pHPT present significantly more NCEP criteria for MetS. We postulate that increased levels of PTH in pHPT may be associated with the increased cardiovascular morbidity and mortality seen in pHPT.
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| 28. |
- Akner, Gunnar, 1953-, et al.
(author)
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Vi står gärna bakom en utfallsbaserad vård
- 2017
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In: Dagens Samhälle. - 1652-6511.
-
Journal article (pop. science, debate, etc.)abstract
- Jörgen Nordenström försöker få det till att vår kritik av värdebaserad vård egentligen handlar om att vi vill ha mer resurser. Han har helt missuppfattat oss, skriver 26 specialistläkare i en replik.
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| 29. |
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| 30. |
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| 31. |
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| 32. |
- Andersson, Per-Erik, et al.
(author)
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Regression of left ventricular wall thickness during ACE-inhibitor treatment of essential hypertension is associated with an increase in insulin mediated skeletal muscle blood flow
- 1998
-
In: Blood Pressure. - 0803-7051 .- 1651-1999. ; 7:2, s. 118-126
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Journal article (peer-reviewed)abstract
- Left ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle. ACE-inhibitors have been reported to be superior to most other antihypertensive drugs in inducing a regression of LVH. In a double-blind study with parallel groups, 50 patients with essential hypertension were randomized to treatment with either fosinopril (20 mg o.d.) or atenolol (50 mg o.d.) for 12-16 weeks. Left ventricle wall thickness (LVWT, defined as the sum of interventricular septum and posterior wall), diastolic function (represented by the ratio between the E-wave and the A-wave of mitral blood flow) and femoral artery blood flow (FBF) were evaluated using ultrasonic measurements. FBF was measured at normoinsulinemia and after 2 h of euglycemic hyperinsulinemia. Before treatment, the insulin-induced increase in FBF was inversely related to the LVWT (r = -0.52, p < 0.02). The reduction in ambulatory 24-h SBP/DBP was 13/9 mmHg for fosinopril and 15/14 for atenolol, ambulatory DBP being significantly more reduced by atenolol (p = 0.03 for difference in treatment effect). However, only fosinopril treatment resulted in a significant reduction in LVWT (from 20.5 mm to 19.4 mm, p < 0.05). The degree of reduction in LVWT was related to the increase in FBF in the fosinopril group (r = -0.45, p < 0.05). For fosinopril (but not for atenolol), there was a positive relationship between the change in E/A ratio and the change in femoral artery stroke volume (r = 0.80, p < 0.01). Conclusion: Impaired insulin-induced stimulation of leg blood flow was related to an increased LVWT. Furthermore, during fosinopril treatment, regression of LVWT was associated with enhanced skeletal muscle blood flow during hyperinsulinemia. This indicates that impaired peripheral blood flow (and thereby increased afterload) may be a possible mechanism explaining the previously found association between insulin resistance and cardiovascular hypertrophy.
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| 33. |
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| 34. |
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| 35. |
- Anund Vogel, Jonas, 1981-
(author)
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Incentivising Innovation in the Swedish Construction Industry
- 2020
-
Doctoral thesis (other academic/artistic)abstract
- Almost 40 percent of global final energy use and CO2 emissions are connected to buildings and building-related activities; it is therefore important to incentivise the design and construction of resource-efficient buildings. Unfortunately, energy demand and associated emissions in the sector continue to grow. Such incentives will help achieve energy and environmental targets, reduce costs, and make smart and sustainable buildings and cities possible at a larger scale. Because novel technologies carry risks alongside their advantages, developers, contractors and consultants must have incentives to reduce and share those risks in a rational way if we are to meet the crucial long-term societal goals of reduced use of resources and emissions. I hypothesise that there are legal and institutional frameworks (rules, building codes, regulations, standard contracts, etc.) that result in weak or negative incentives for construction industry actors to invest in, propose, and install resource-efficient technologies. If the hypothesis holds true, then the goal is to identify ways to better incentivise construction industry actors to fully engage in the design and construction of smart and sustainable buildings. To tackle this, four studies were carried out using a mixed-method approach. Paper 1 identifies 38 barriers to energy efficiency in Swedish multifamily buildings. The next study (Paper 2) develops a categorisation framework in order to understand where to engage to overcome or bypass barriers to energy efficiency. Paper 3 and 4 are devoted to analysing two sets of barriers and propose possible solutions to overcome or avoid them: (1) how the current legal framework guiding start and operation of housing co-operatives (mainly the Co-operative Act) influences incentives for engaging in resource-efficient construction, and (2) how the legal instrument for collaboration between developers and consultants incentivises resource-efficient construction. In this case, the contract under investigation is the General Conditions of Contract for Consulting Agreements for Architectural and Engineering Assignments (ABK 09)”. Changes to these two sets of legal and institutional frameworks could have a significant impact on how buildings are designed, produced and used. The changes proposed could incentivise construction industry actors to fully pursue the creation of smart, sustainable buildings that deliver services to users and reduce negative environmental impacts stemming from both the building construction and operation phases.
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| 36. |
- Anund Vogel, Jonas, 1981-, et al.
(author)
-
Who is Governing the Commons : Studying Swedish Housing Cooperatives
- 2016
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In: Housing, Theory and Society. - : Taylor & Francis. - 1403-6096 .- 1651-2278. ; 33:4, s. 424-444
-
Journal article (peer-reviewed)abstract
- This study examines current governance structures related to multifamily buildings designed by single actors (developers) and operated in cooperative forms. The study analyses the long-term sustainability of the resource regime of study (multifamily buildings) and inked governance structures by applying Ostrom’s eight design principles for long-term survival of self-organized resource regimes (Common-pool resources or CPR’s). The study also searches for signs of movement towards social innovation and collective action in current governance structures. We argue that the structures governing planning, production and operation of housing cooperatives in Sweden do not fulfil the eight design principles for the long-term survival of the resource regime of study, nor do they encourage movement towards social innovation or collective action. In order to ensure the long-term survival of the resource regime of study and to increase innovation in governance structures, five adjustments are proposed; changes in the structures governing risk/profit distribution, communication, collaboration and information between actors in the Swedish cooperative housing sector.
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| 37. |
- Arm, Maria, et al.
(author)
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Pulp mill fly ash for stabilization of low-volume unpaved forest roads — field performance
- 2014
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In: Canadian journal of civil engineering (Print). - : Canadian Science Publishing. - 0315-1468 .- 1208-6029. ; 41:11, s. 955-963
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Journal article (peer-reviewed)abstract
- Increased temperatures and rainfalls will give more settlements and less bearing capacity in gravel roads, which will have implications for the forestry. Pulp mill fly ash without additives was used for stabilizing the road base of a low-volume gravel road. A two-year monitoring of the road was conducted, including measurements of achieved ash content, density, water infiltration capacity, and load bearing capacity. The results showed that the ash-stabilized sections performed better than conventionally upgraded sections and also achieved increased bearing capacity over time. Hydration of the fly ash increased the stiffness and decreased the permeability of the road base. The differences were more pronounced during spring thaw. Best performance was achieved in the section with thicker ash stabilized layer.
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| 38. |
- Arvidsson, Per I., et al.
(author)
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Öppenheten förstör chansen till patent
- 2015
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In: Svenska dagbladet. - Stockholm : Svenska Dagbladet AB & Co.. - 2001-3868.
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Journal article (pop. science, debate, etc.)
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| 39. |
- Baumane, Ilona, et al.
(author)
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Innovation capabilities in tourism and food production SMEs in the Baltic Sea Region
- 2011
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In: International Journal of Knowledge Management Studies. - Olney : InderScience Publishers. - 1743-8268 .- 1743-8276. ; 4:4, s. 336-358
-
Journal article (peer-reviewed)abstract
- Drawing on the resource-based view, this paper addresses two fundamental questions: what innovation capabilities are most important for the creation of innovations in Small and Medium-sized Enterprises (SMEs) and what are the relations between different innovation capabilities? We propose a model for the analysis of innovation capabilities in small and medium enterprises. In the model, we distinguish between capacities, such as access to financial, physical, technological and human resources, and competencies, such as knowledge and skills, market and entrepreneurial orientation. The findings are based on surveys from 277 tourism and food production SMEs from five Baltic Sea Region countries.
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| 40. |
- Bergström, Göran, 1964, et al.
(author)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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In: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
-
Journal article (peer-reviewed)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 41. |
- Bergström, Göran, et al.
(author)
-
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
-
In: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
-
Journal article (peer-reviewed)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 42. |
- Bergström, Göran, et al.
(author)
-
Self-report tool for identification of individuals with coronary atherosclerosis : the Swedish cardiopulmonary bioimage study
- 2024
-
In: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 13:14
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P<0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly.CONCLUSIONS: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
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| 43. |
- Berndt, Sonja I., et al.
(author)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
-
Journal article (peer-reviewed)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 44. |
- Bjermo, Helena, et al.
(author)
-
Serum levels of brominated flame retardants (BFRs : PBDE, HBCD) and influence of dietary factors in a population-based study on Swedish adults
- 2017
-
In: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 167, s. 485-491
-
Journal article (peer-reviewed)abstract
- The aim of this study was to investigate associations between serum concentrations of brominated flame retardants and personal characteristics, including diet, in adults participating in a population-based study in Sweden 2010-11. Moreover, observed concentrations were used in a health risk assessment, using published health-based reference values. Serum samples of 170 adult individuals of both sexes were analyzed for 10 PBDE congeners and HBCD by GC-MS. When including concentrations between LOD and LOQ, highest median serum concentration was observed for BDE-153 (1.2 ng/g serum lipid), followed by BDE-209 (0.95 ng/g lipid), BDE-47 (0.49 ng/g lipid) and BDE-100 (0.21 ng/g lipid). Median concentration of HBCD was 0.10 ng/g lipid. A few markedly elevated concentrations of BDE-209, HBCD (77-78 ng/g lipid) and BDE-47 (44 ng/g lipid) were observed. The only statistical significant findings were higher BDE-153 concentrations in men than in women, and positive associations between serum BDE-153 concentrations and consumption of fish (total), beef, mutton and poultry. PBDE concentrations were in accordance with concentrations reported in other European countries but generally lower than those found in North America. Median PBDE serum concentrations observed in adults from Sweden suggest sufficient health protection, when compared with published health-based reference values, although some outliers with high serum concentrations had lower safety margins.
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| 45. |
- Bjällmark, Anna, et al.
(author)
-
Velocity tracking - a novel method for quantitative analysis of longitudinal myocardial function
- 2007
-
In: Journal of the American Society of Echocardiography. - : Elsevier. - 0894-7317 .- 1097-6795. ; 20:7, s. 847-856
-
Journal article (peer-reviewed)abstract
- Doppler tissue imaging is a method for quantitative analysis of longitudinal myocardial velocity. Commercially available ultrasound systems can only present velocity information using a color Dopplerbased overlapping continuous color scale. The analysis is time-consuming and does not allow for simultaneous analysis in different projections. We have developed a new method, velocity tracking, using a stepwise color coding of the regional longitudinal myocardial velocity. The velocity data from 3 apical projections are presented as static and dynamic bull's-eye plots to give a 3-dimensional understanding of the function of the left ventricle. The static bull's-eye plot can display peak systolic velocity, late diastofic tissue velocity, or the sum of peak systolic velocity and early diastolic tissue velocity. Conversely, the dynamic bull's-eye plot displays how the myocardial velocities change over one heart cycle. Velocity tracking allows for a fast, simple, and hituitive visual analysis of the regional longitudinal contraction pattern of the left ventricle with a great potential to identify characteristic pathologic patterns.
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| 46. |
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| 47. |
- Cameron, Christopher, et al.
(author)
-
Balancing structural and acoustic performance of sandwich panels for vehicle applications with topology, property, and size optimization
- 2010
-
In: 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. - : ACCM-7 Organizing Committee. - 9781632660756 ; , s. 835-838
-
Conference paper (peer-reviewed)abstract
- Within this paper, a process for the design of a multifunctional sandwich body panel for vehicle applications is proposed. The method, presented with a case study, attempts to achieve a balance between structural and acoustic performance using numerical tools for topology optimization and combined size and property optimization. The goal of the work is to achieve an optimal distribution of traditional sandwich foam material and light weight acoustic foam within the core of the panel. The significance of the coupling between the panels inner face sheet and the acoustic foam is examined and proves to be a critical parameter in the design. An adaptation to existing topology optimization schemes is proposed to deal with the presence or absence of such a coupling. The results show promise in simplifying construction, reducing weight, and streamlining the assembly process.
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| 48. |
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| 49. |
- Cameron, Christopher John, et al.
(author)
-
Material Property Steered Optimization of a Multifunctional Body Panel to Structural and Acoustic Constraints
- 2009
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In: Proceedings of the 17th International Conference on Composite Materials.
-
Conference paper (other academic/artistic)abstract
- A conventional automobile roof, including structural and interior trim components, is replaced with a multi-layer, multi-functional sandwich construction. A weight optimizationis performed to tailor the material properties of the composite face sheets and multiple foam layers to meet structural constraints and acoustic requirements.
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| 50. |
- Cameron, Christopher John, 1980-, et al.
(author)
-
Material Property Steered Structural and Acoustic Optimization of a Multifunctional Vehcile Body Panel
-
Other publication (other academic/artistic)abstract
- Conventional vehicle passenger compartments often achieve functional requirements using a complex assembly of components. As each component is optimized for a single task, the assembly as a whole is often suboptimal in achieving the system performance requirements. In this paper, a novel iterative design approach based on using a multi-layered load bearing sandwich panel with integrated acoustic capabilitiesis developed focusing on material properties and their effecton the systems behavior. The proposed panel is meant to fulfilmultiple system functionalities simultaneously, thus simplifying the assembly and reducing mass. Open cell acoustic foams are used to achieve acoustic performance, and the effect of altering the stacking sequence as well as introducing an air gap within the acoustic treatment is studied in detail to determine effects on the acoustic and structural performance of the panel as a whole.
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