| 1. |
- Abele, H., et al.
(author)
-
Particle physics at the European Spallation Source
- 2023
-
In: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 1023, s. 1-84
-
Research review (peer-reviewed)abstract
- Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world’s brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).
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| 2. |
- Villa, Luisa L., et al.
(author)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 3. |
- Burgman, A., et al.
(author)
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The ESSnuSB Design Study: Overview and Future Prospects
- 2023
-
In: Universe. - : MDPI. - 2218-1997. ; 9:8
-
Research review (peer-reviewed)abstract
- ESSnuSB is a design study for an experiment to measure the CP violation in the leptonic sector at the second neutrino oscillation maximum using a neutrino beam driven by the uniquely powerful ESS linear accelerator. The reduced impact of systematic errors on sensitivity at the second maximum allows for a very precise measurement of the CP violating parameter. This review describes the fundamental advantages of measurement at the second maximum, the necessary upgrades to the ESS linac in order to produce a neutrino beam, the near and far detector complexes, and the expected physics reach of the proposed ESSnuSB experiment, concluding with the near future developments aimed at the project realization.
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| 4. |
- Burgman, A., et al.
(author)
-
The European Spallation Source neutrino super-beam conceptual design report
- 2022
-
In: The European Physical Journal Special Topics. - : Springer Nature. - 1951-6355 .- 1951-6401. ; 231:21, s. 3779-3955
-
Research review (peer-reviewed)abstract
- A design study, named ESSνSB for European Spallation Source neutrino Super Beam, has been carried out during the years 2018–2022 of how the 5 MW proton linear accelerator of the European Spallation Source under construction in Lund, Sweden, can be used to produce the world’s most intense long-baseline neutrino beam. The high beam intensity will allow for measuring the neutrino oscillations near the second oscillation maximum at which the CP violation signal is close to three times higher than at the first maximum, where other experiments measure. This will enable CP violation discovery in the leptonic sector for a wider range of values of the CP violating phase δCPδCP and, in particular, a higher precision measurement of δCPδCP. The present Conceptual Design Report describes the results of the design study of the required upgrade of the ESS linac, of the accumulator ring used to compress the linac pulses from 2.86 ms to 1.2 μs, and of the target station, where the 5 MW proton beam is used to produce the intense neutrino beam. It also presents the design of the near detector, which is used to monitor the neutrino beam as well as to measure neutrino cross sections, and of the large underground far detector located 360 km from ESS, where the magnitude of the oscillation appearance of νe from νμ is measured. The physics performance of the ESSνSB research facility has been evaluated demonstrating that after 10 years of data-taking, leptonic CP violation can be detected with more than 5 standard deviation significance over 70% of the range of values that the CP violation phase angle δCPδCP can take and that δCPδCP can be measured with a standard error less than 8° irrespective of the measured value of δCPδCP. These results demonstrate the uniquely high physics performance of the proposed ESSνSBESSνSB research facility.
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| 5. |
- Santoro, V., et al.
(author)
-
HighNESS conceptual design report: Volume I
- 2024
-
In: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 85-314
-
Journal article (peer-reviewed)abstract
- The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) has been completed to develop a second neutron source located below the spallation target. Compared to the first source, designed for high cold and thermal brightness, the new source has been optimized to deliver higher intensity, and a shift to longer wavelengths in the spectral regions of cold (CN, 2–20 Å), very cold (VCN, 10–120 Å), and ultracold (UCN, >500 Å) neutrons. The second source comprises a large liquid deuterium moderator designed to produce CN and support secondary VCN and UCN sources. Various options have been explored in the proposed designs, aiming for world-leading performance in neutronics. These designs will enable the development of several new instrument concepts and facilitate the implementation of a high-sensitivity neutron-antineutron oscillation experiment (NNBAR). This document serves as the Conceptual Design Report for the HighNESS project, representing its final deliverable.
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| 6. |
- Santoro, V., et al.
(author)
-
HighNESS conceptual design report: Volume II. the NNBAR experiment.
- 2024
-
In: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 315-406
-
Journal article (peer-reviewed)abstract
- A key aim of the HighNESS project for the European Spallation Source is to enable cutting-edge particle physics experiments. This volume presents a conceptual design report for the NNBAR experiment. NNBAR would exploit a new cold lower moderator to make the first search in over thirty years for free neutrons converting to anti-neutrons. The observation of such a baryon-number-violating signature would be of fundamental significance and tackle open questions in modern physics, including the origin of the matter-antimatter asymmetry. This report shows the design of the beamline, supermirror focusing system, magnetic and radiation shielding, and anti-neutron detector necessary for the experiment. A range of simulation programs are employed to quantify the performance of the experiment and show how background can be suppressed. For a search with full background suppression, a sensitivity improvement of three orders of magnitude is expected, as compared with the previous search. Civil engineering studies for the NNBAR beamline are also shown, as is a costing model for the experiment.
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| 7. |
- Addazi, A., et al.
(author)
-
New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source
- 2021
-
In: Journal of Physics G. - : Institute of Physics Publishing (IOPP). - 0954-3899 .- 1361-6471. ; 48:7
-
Journal article (peer-reviewed)abstract
- The violation of baryon number, , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation () via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state (), and neutron disappearance (n → n'); the effective process of neutron regeneration () is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis and the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.
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| 8. |
- Aguilar, J., et al.
(author)
-
Search for Leptonic CP Violation with the ESSnuSBplus Project
- 2024
-
In: Letters in High Energy Physics. - : Andromeda Publishing And Academic Services LTD. - 2632-2714.
-
Journal article (peer-reviewed)abstract
- ESSνSB is a design study for a next-generation long-baseline neutrino experiment that aims at the precise measurement of the CP-violating phase, δCP, in the leptonic sector at the second oscillation maximum. The conceptual design report published from the first phase of the project showed that after 10 years of data taking, more than 70% of the possible δCP range will be covered with 5σ C.L. to reject the no-CP-violation hypothesis. The expected value of δCP precision is smaller than 8◦ for all δCP values. The next phase of the project, the ESSνSB+, aims at using the intense muon flux produced together with neutrinos to measure the neutrino-nucleus cross-section, the dominant term of the systematic uncertainty, in the energy range of 0.2–0.6 GeV, using a Low Energy neutrinos from STORed Muons (LEnuSTORM) and a Low Energy Monitored Neutrino Beam (LEMNB) facilities.
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| 9. |
- Aguilar, J., et al.
(author)
-
Study of nonstandard interactions mediated by a scalar field at the ESSnuSB experiment
- 2024
-
In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 109:11
-
Journal article (peer-reviewed)abstract
- In this paper, we study scalar mediator induced nonstandard interactions (SNSIs) in the context of the ESSnuSB experiment. In particular, we study the capability of ESSnuSB to put bounds on the SNSI parameters and also study the impact of SNSIs in the measurement of the leptonic CP phase δCP. Existence of SNSIs modifies the neutrino mass matrix and this modification can be expressed in terms of three diagonal real parameters (ηee, ημμ, and ηττ) and three off-diagonal complex parameters (ηeμ, ηeτ, and ημτ). Our study shows that the upper bounds on the parameters ημμ and ηττ depend upon how Δm312 is minimized in the theory. However, this is not the case when one tries to measure the impact of SNSIs on δCP. Further, we show that the CP sensitivity of ESSnuSB can be completely lost for certain values of ηee and ημτ for which the appearance channel probability becomes independent of δCP.
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| 10. |
- Aguilar, J., et al.
(author)
-
Study of nonstandard interactions mediated by a scalar field at the ESSnuSB experiment
- 2024
-
In: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 109:11
-
Journal article (peer-reviewed)abstract
- In this paper, we study scalar mediator induced nonstandard interactions (SNSIs) in the context of the ESSnuSB experiment. In particular, we study the capability of ESSnuSB to put bounds on the SNSI parameters and also study the impact of SNSIs in the measurement of the leptonic ?? phase ???. Existence of SNSIs modifies the neutrino mass matrix and this modification can be expressed in terms of three diagonal real parameters (???, ???, and ???) and three off-diagonal complex parameters (???, ???, and ???). Our study shows that the upper bounds on the parameters ??? and ??? depend upon how Δ?231 is minimized in the theory. However, this is not the case when one tries to measure the impact of SNSIs on ???. Further, we show that the ?? sensitivity of ESSnuSB can be completely lost for certain values of ??? and ??? for which the appearance channel probability becomes independent of ???.
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| 11. |
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| 12. |
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| 13. |
- Burgman, A., et al.
(author)
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Updated physics performance of the ESSnuSB experiment
- 2021
-
In: European Physical Journal C. - : Springer Nature. - 1434-6044 .- 1434-6052. ; 81:12
-
Journal article (peer-reviewed)abstract
- In this paper, we present the physics performance of the ESSnuSB experiment in the standard three flavor scenario using the updated neutrino flux calculated specifically for the ESSnuSB configuration and updated migration matrices for the far detector. Taking conservative systematic uncertainties corresponding to a normalization error of 5% for signal and 10% for background, we find that there is 10 sigma (13 sigma) CP violation discovery sensitivity for the baseline option of 540 km (360 km) at delta(CP) = +/- 90 degrees. The corresponding fraction of delta(CP )for which CP violation can be discovered at more than 5 sigma is 70%. Regarding CP precision measurements, the 1 sigma error associated with delta(CP )= 0 degrees is around 5 degrees and with delta(CP )= -90 degrees is around 14 degrees (7 degrees) for the baseline option of 540 km (360 km). For hierarchy sensitivity, one can have 3 sigma sensitivity for 540 km baseline except delta(CP) = +/- 90 degrees and 5 sigma sensitivity for 360 km baseline for all values of delta(CP). The octant of theta(23) can be determined at 30 for the values of: theta(23) > 51 degrees (theta(23) < 42 degrees and theta(23) > 49 degrees) for baseline of 540 km (360 km). Regarding measurement precision of the atmospheric mixing parameters, the allowed values at 3 sigma are: 40 degrees < theta(23) < 52 degrees (42 degrees < theta(23) < 51.5 degrees) and 2.485 x 10(-3) eV(2) < Delta(2)(m31) < 2.545 x 10(-3) eV(2) (2.49x 10(-3 ) eV(2) < Delta(2)(m31) < 2.54 x 10(-3) eV(2)) for the baseline of 540 km (360 km).
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| 14. |
- Du, K., et al.
(author)
-
Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons
- 2017
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 114:36, s. E7612-E7621
-
Journal article (peer-reviewed)abstract
- Striatal spiny projection neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus. Activation of spatially clustered and temporally synchronized excitatory inputs at the distal dendrites could trigger plateau potentials in SPNs. Such supralinear synaptic integration is crucial for dendritic computation. However, how plateau potentials interact with subsequent excitatory and inhibitory synaptic inputs remains unknown. By combining computational simulation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and GABA, we demonstrate that plateau potentials can broaden the spatiotemporal window for integrating excitatory inputs and promote spiking. The temporal window of spiking can be delicately controlled by GABAergic inhibition in a cell-type–specific manner. This subtle inhibitory control of plateau potential depends on the location and kinetics of the GABAergic inputs and is achieved by the balance between relief and reestablishment of NMDA receptor Mg2+ block. These findings represent a mechanism for controlling spatiotemporal synaptic integration in SPNs.
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| 15. |
- Hoff, P, et al.
(author)
-
Nuclear spectroscopy at Sn-133
- 2000
-
In: HYPERFINE INTERACTIONS. - : BALTZER SCI PUBL BV. - 0304-3843. ; 129:1-4, s. 141-148
-
Journal article (other academic/artistic)abstract
- It is described how the measurement of n gamma -coincidences can be used to identify single-particle states in Sn-133. This method, in combination with the improved yields at ISOLDE, has facilitated firm determination of three excited single-particle stat
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| 16. |
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| 17. |
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| 18. |
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Escaned, Javier, et al.
(author)
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Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes
- 2018
-
In: JACC. - : Elsevier. - 1936-8798 .- 1876-7605. ; 11:15, s. 1437-1449
-
Journal article (peer-reviewed)abstract
- OBJECTIVES The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization. METHODS The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated. Patients were stratified according to revascularization decision making on the basis of iFR or FFR and to clinical presentation (SAP or ACS). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization at 1 year. RESULTS Coronary revascularization was deferred in 2,130 patients. Deferral was performed in 1,117 patients (50%) in the iFR group and 1,013 patients (45%) in the FFR group (p < 0.01). At 1 year, the MACE rate in the deferred population was similar between the iFR and FFR groups (4.12% vs. 4.05%; fully adjusted hazard ratio: 1.13; 95% confidence interval: 0.72 to 1.79; p = 0.60). A clinical presentation with ACS was associated with a higher MACE rate compared with SAP in deferred patients (5.91% vs. 3.64% in ACS and SAP, respectively; fully adjusted hazard ratio: 0.61 in favor of SAP; 95% confidence interval: 0.38 to 0.99; p = 0.04). CONCLUSIONS Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used to assess physiological significance. In deferred patients presenting with ACS, the event rate was significantly increased compared with SAP at 1 year. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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| 23. |
- Fedosseev, V. N., et al.
(author)
-
ISOLDE RILIS : New beams, new facilities
- 2008
-
In: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier BV. - 0168-583X .- 1872-9584. ; 266:19-20, s. 4378-4382
-
Journal article (peer-reviewed)abstract
- The resonance ionization laser ion source (RILIS) at the ISOLDE on-line isotope separator is based on the selective excitation of atomic transitions by tunable laser radiation. New ion beams have been produced with RILIS in recent years: Sb, Sc, Dy, Au, Hg and Po. In total, isotopes of 26 different elements have been selectively laser-ionized and separated at ISOLDE. In order to facilitate the work on development of atomic ionization schemes an off-line laser laboratory has been established at CERN. Operating independently of the on-line RI LIS setup, this laboratory will be capable of providing extensive data on atomic transitions, in particular between highly excited and auto-ionizing atomic states, which are required for the improvement of the RILIS efficiency. Additionally, the program gram of upgrading the on-line RI LIS system by the implementation of solid state lasers will be presented.
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| 24. |
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| 25. |
- Foucault, C, et al.
(author)
-
Multispacer typing technique for sequence-based typing of Bartonella quintana
- 2005
-
In: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 43:1, s. 41-48
-
Journal article (peer-reviewed)abstract
- Bartonella quintana is a worldwide fastidious bacterium of the Alphaproteobacteria responsible for bacillary angiomatosis, trench fever, chronic lymphadenopathy, and culture-negative endocarditis. The recent genome sequencing of a B. quintana isolate allowed us to propose a genome-wide sequence-based typing method. To ensure sequence discrimination based on highly polymorphic areas, we amplified and sequenced 34 spacers in a large collection of B. quintana isolates. Six of these exhibited polymorphisms and allowed the characterization of 4 genotypes. However, the strain variants suggested by the noncoding sequences did not correlate with the results of pulsed-field gel electrophoresis (PFGE), which suggested a higher degree of variability. Modification of the PFGE profile of one isolate after nine subcultures confirmed that rearrangement frequencies are high in this species, making PFGE unreliable for epidemiological purposes. The low extent of sequence heterogeneity in the species suggests a recent emergence of this bacterium as a human pathogen. Direct typing of natural samples allowed the identification of a fifth genotype in the DNA extracted from a human body louse collected in Burundi. We have named the typing technique herein described multispacer typing.
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| 26. |
- Hoff, P, et al.
(author)
-
Single-neutron states in Sn-133
- 1996
-
In: PHYSICAL REVIEW LETTERS. - : AMER INST PHYSICS. - 0031-9007. ; 77:6, s. 1020-1023
-
Journal article (peer-reviewed)abstract
- The location of several single-neutron states in Sn-133 has been identified. The P-3/2, h(9/2), and f(5/2) states were found at 853.7, 1560.9, and 2004.6 keV, respectively, by measuring gamma rays in coincidence with delayed neutrons following the decay o
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| 27. |
- Kester, O., et al.
(author)
-
Accelerated radioactive beams from REX-ISOLDE
- 2003
-
In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - 0168-583X. ; 204, s. 20-20
-
Conference paper (peer-reviewed)abstract
- In 2001 the linear accelerator of the Radioactive beam EXperiment (REX-ISOLDE) delivered for the first time accelerated radioactive ion beams, at a beam energy of 2 MeV/u. REX-ISOLDE uses the method of charge-state breeding, in order to enhance the charge state of the ions before injection into the LINAC. Radioactive singly-charged ions from the on-line mass separator ISOLDE are first accumulated in a Penning trap, then charge bred to an A/q
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| 28. |
- Knudsen, Kirsten Kraiberg, 1976, et al.
(author)
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C II emission in z similar to 6 strongly lensed, star-forming galaxies
- 2016
-
In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3925 .- 1745-3933. ; 462:1, s. L6-L10
-
Journal article (peer-reviewed)abstract
- The far-infrared fine-structure line [C II] at 1900.5 GHz is known to be one of the brightest cooling lines in local galaxies, and therefore it has been suggested to be an efficient tracer for star formation in very high redshift galaxies. However, recent results for galaxies at z > 6 have yielded numerous non-detections in star-forming galaxies, except for quasars and submillimetre galaxies. We report the results of ALMA observations of two lensed, star-forming galaxies at z = 6.029 and z = 6.703. The galaxy A383-5.1 (star formation rate [SFR] of 3.2 M-circle dot yr(-1) and magnification of mu = 11.4 +/- 1.9) shows a line detection with L-[C II] = 8.9 x 10(6) L-circle dot, making it the lowest L-[C II] detection at z > 6. For MS0451-H (SFR = 0.4 M-circle dot yr(-1) and mu = 100 +/- 20) we provide an upper limit of L-[C II] 6; however, other effects could also play a role in terms of decreasing L-[CII]. The detection of A383-5.1 is encouraging and suggests that detections are possible, but much fainter than initially predicted.
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| 29. |
- Lindroos, Lukas, 1986, et al.
(author)
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Measuring size evolution of distant, faint galaxies in the radio regime
- 2018
-
In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 476:3, s. 3544-3554
-
Journal article (peer-reviewed)abstract
- We measure the evolution of sizes for star-forming galaxies as seen in 1.4 GHz continuum radio for z = 0-3. The measurements are based on combined VLA+MERLIN data of the Hubble Deep Field, and using a uv-stacking algorithm combined with model fitting to estimate the average sizes of galaxies. A sample of similar to 1000 star-forming galaxies is selected from optical and near-infrared catalogues, with stellar masses Me-circle dot approximate to 10(10)-10(11) M-circle dot and photometric redshifts 0-3. The median sizes are parametrized for stellar mass M-* = 5 x 10(10) M-circle dot as R-e = A x (H(z)/H(1.5))(alpha z). We find that the median radio sizes evolve towards larger sizes at later times with alpha(z) = 1.1 +/- 0.6, and A (the median size at z approximate to 1.5) is found to be 0 ''.26 +/- 0 ''.07 or 2.3 +/- 0.6 kpc. The measured radio sizes are typically a factor of 2 smaller than those measure in the optical, and are also smaller than the typical H alpha sizes in the literature. This indicates that star formation, as traced by the radio continuum, is typically concentrated towards the centre of galaxies, for the sampled redshift range. Furthermore, the discrepancy of measured sizes from different tracers of star formation, indicates the need for models of size evolution to adopt a multiwavelength approach in the measurement of the sizes star-forming regions.
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| 30. |
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| 31. |
- Marsh, B. A., et al.
(author)
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The ISOLDE RILIS pump laser upgrade and the LARIS Laboratory
- 2010
-
In: Hyperfine Interactions. - : Springer Nature. - 0304-3843 .- 1572-9540. ; 196:1-3, s. 129-141
-
Journal article (peer-reviewed)abstract
- On account of its high efficiency, speed and unmatched selectivity, the Resonance Ionization Laser Ion Source (RILIS) is the preferred method for ionizing the nuclear reaction products at the ISOLDE on-line isotope separator facility. By exploiting the unique electronic energy level 'fingerprint' of a chosen element, the RILIS process of laser step-wise resonance ionization enables an ion beam of high chemical purity to be sent through the mass selective separator magnet. The isobaric purity of a beam of a chosen isotope is therefore greatly increased. The RILIS, comprising of up to three frequency tunable pulsed dye lasers has been upgraded with the installation of a Nd:YAG pump laser as a replacement for the old Copper Vapor Laser (CVL) system. A summary of the current Nd:YAG pumped RILIS performance is given. To accompany the RILIS pump laser upgrade, a new ionization scheme for manganese has been developed at the newly constructed LAser Resonance Ionization Spectroscopy (LARIS) laboratory and successfully applied for on-line RILIS operation. An overview of the LARIS facility is given along with details of the ionization scheme development work for manganese.
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| 32. |
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| 33. |
- Nyström, Christine Delisle, et al.
(author)
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Results From Sweden's 2016 Report Card on Physical Activity for Children and Youth.
- 2016
-
In: Journal of physical activity & health. - : Human Kinetics. - 1543-5474 .- 1543-3080. ; 13:11 Suppl 2
-
Journal article (peer-reviewed)abstract
- The 2016 Swedish Report Card on Physical Activity (PA) for Children and Youth is a unique compilation of the existing physical and health related data in Sweden. The aim of this article is to summarize the procedure and results from the report card.Nationally representative surveys and individual studies published between 2005-2015 were included. Eleven PA and health indicators were graded using the Active Healthy Kids Canada grading system. Grades were assigned based on the percentage of children/youth meeting a defined benchmark (A: 81% to 100%, B: 61% to 80%, C: 41% to 60%, D: 21% to 40%, F: 0% to 20%, or incomplete (INC).The assigned grades were Overall Physical Activity, D; Organized Sport Participation, B+; Active Play, INC; Active Transportation, C+; Sedentary Behaviors, C; Family and Peers, INC; School, C+; Community and the Built Environment, B; Government Strategies and Investments, B; Diet, C-; and Obesity, D.The included data provides some support that overall PA is too low and sedentary behavior is too high for almost all age groups in Sweden, even with the many national policies as well as an environment that is favorable to the promotion of PA.
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| 34. |
- Riess, Tanja, et al.
(author)
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Bartonella adhesin A mediates a proangiogenic host cell response
- 2004
-
In: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 200:10, s. 1267-1278
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Journal article (peer-reviewed)abstract
- Bartonella henselae causes vasculoproliferative disorders in humans. We identified a nonfimbrial adhesin of B. henselae designated as Bartonella adhesin A (BadA). BadA is a 340-kD outer membrane protein encoded by the 9.3-kb badA gene. It has a modular structure and contains domains homologous to the Yersinia enterocolitica nonfimbrial adhesin (Yersinia adhesin A). Expression of BadA was restored in a BadA-deficient transposon mutant by complementation in trans. BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via β1 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae–infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders.
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| 35. |
- Sigurdsson, S, et al.
(author)
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Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
- 2005
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 76:3, s. 528-37
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Journal article (peer-reviewed)abstract
- Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by both genetic and environmental factors. Genome scans in families with SLE point to multiple potential chromosomal regions that harbor SLE susceptibility genes, and association studies in different populations have suggested several susceptibility alleles for SLE. Increased production of type I interferon (IFN) and expression of IFN-inducible genes is commonly observed in SLE and may be pivotal in the molecular pathogenesis of the disease. We analyzed 44 single-nucleotide polymorphisms ( SNPs) in 13 genes from the type I IFN pathway in 679 Swedish, Finnish, and Icelandic patients with SLE, in 798 unaffected family members, and in 438 unrelated control individuals for joint linkage and association with SLE. In two of the genes - the tyrosine kinase 2 (TYK2) and IFN regulatory factor 5 (IRF5) genes - we identified SNPs that displayed strong signals in joint analysis of linkage and association (unadjusted P < 10(-7)) with SLE. TYK2 binds to the type I IFN receptor complex and IRF5 is a regulator of type I IFN gene expression. Thus, our results support a disease mechanism in SLE that involves key components of the type I IFN system.
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| 36. |
- Sjöström, Lars, et al.
(author)
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Swedish obese subjects (SOS). Recruitment for an intervention study and a selected description of the obese state
- 1992
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In: International Journal of Obesity. ; 19, s. 465-479
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Journal article (peer-reviewed)abstract
- Department of Medicine, Sahlgren's Hospital, University of Göteborg, Sweden. SOS (Swedish obese subjects) is an on-going intervention trial designed to determine whether the mortality and morbidity rates among obese individuals who lose weight by surgical means (gastric banding, vertical banded gastroplasty and gastric by-pass) differ from the rates associated with conventional treatment. For this purpose, the study is recruiting a sample of obese men and women who constitute a registry of potential subjects from which the participants are drawn. Eligibility criteria for participation in the registry were: age at application 37-57 years and BMI greater than or equal to 34 kg/m2 for men and greater than or equal to 38 kg/m2 for women. Before receiving a health examination, all patients complete extensive questionnaires on current and past health status, utilization of medical care and medications, socio-economic status, psychological profiles, dietary habits, physical activity, weight history, and familial disposition to obesity. Each surgical case is matched to its optimal control in the registry, to ensure that the two groups do not differ systematically with respect to any of 18 matching variables that may affect prognosis. The first 1006 subjects included in the registry have been studied with respect to morbidity and compared with on-going population studies of men and women in Göteborg, Sweden. The relative risks of prevalent disease and symptoms associated with obesity in 50-year-old males and females respectively were 4.3 and 4.7 (dyspnoea), 14.7 and 11.8 (angina), 6.3 (myocardial infarction, males only), 2.1 and 4.5 (hypertension), 5.2 and 6.6 (diabetes), 4.6 and 26.1 (claudication) and 1.7 and 1.8 (gall bladder disease). Correspondingly, obese males and females display elevations of systolic and diastolic blood pressure, fasting glucose, insulin, triglyceride, and uric acid levels. However, total cholesterol was not increased in obese males and was in fact significantly lower in obese compared with reference women. HDL-cholesterol was lower in obese than reference men (data were not available in reference women). The rate of taking sick pensions was over twice as high in SOS obese patients than in population controls. Finally, comparison of measurements with self-reported prevalence estimates revealed a considerable amount of previously undiagnosed hypertension and diabetes in the obese subjects. These data suggest that the excess health risks associated with obesity may not be fully appreciated. PMID: 1322873 [PubMed - indexed for MEDLINE]
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| 37. |
- Strid, Anna, et al.
(author)
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Adherence to the Swedish dietary guidelines and the impact on mortality and climate in a population-based cohort study
- 2023
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In: Public Health Nutrition. - 1368-9800.
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Journal article (peer-reviewed)abstract
- Objective:To assess the associations between adherence to the Swedish dietary guidelines and all-cause mortality (i.e. assessing the index' ability to predict health outcomes), as well as levels of dietary greenhouse gas emissions (GHGEs). Design:A longitudinal study 1990-2016 within the population-based cohort Vasterbotten Intervention Programme. Dietary data were based on FFQs. Diet quality was assessed by the Swedish Healthy Eating Index for Adults 2015 (SHEIA15), based on the 2015 Swedish dietary guidelines. Dietary GHGEs were estimated from life cycle assessment data including emissions from farm to industry gate. Hazard ratios (HR) and 95 % CI of all-cause mortality were evaluated with Cox proportional hazards regression, and differences in median GHGEs were tested between quintiles of SHEIA15 score using the Kruskal-Wallis one-way ANOVA test. Setting:Northern Sweden. Participants:In total, 49 124 women and 47 651 men, aged 35-65 years. Results:Median follow-up times were 16 & BULL;0 years for women and 14 & BULL;7 years for men, during which time 3074 women and 4212 men died. A consistent trend of lower all-cause mortality HR for both sexes with higher SHEIA15 scores was demonstrated. For women, the all-cause mortality HR was 0 & BULL;81 ((95 % CI 0 & BULL;71, 0 & BULL;92); P = 0 & BULL;001) and for men 0 & BULL;90 ((95 % CI 0 & BULL;81, 0 & BULL;996); P = 0 & BULL;041) between the quintile with the highest SHEIA15 score compared with the quintile with the lowest SHEIA15 score. A consistent trend of lower estimated dietary GHGEs among both sexes with higher SHEIA15 scores was also found. Conclusions:Adherence to Swedish dietary guidelines, estimated by SHEIA15, seems to promote longevity and reduce dietary climate impact.
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| 38. |
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| 39. |
- Vagstrand, K., et al.
(author)
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Eating habits in relation to body fatness and gender in adolescents--results from the 'SWEDES' study
- 2007
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In: Eur J Clin Nutr. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 61:4, s. 517-25
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To investigate if eating habits among adolescents are related to body fatness and gender. DESIGN: Cross-sectional study. SETTING: Obesity Unit, Huddinge University Hospital, Sweden, 2001-2002. SUBJECTS: Two hundred and seventy-five girls and 199 boys, aged 16-17 years. METHOD: Questionnaires were used for dietary intake and meal frequency, BodPod for measuring body fatness (BF%). In all, 169 girls and 128 boys were classified as adequate reporters (AR) of energy intake, and were used in the dietary analyses. The whole sample was used in the meal frequency analyses. RESULTS: The correlation between reported energy intake and weight in the AR group was 0.23 (P<0.01) for girls and 0.36 for boys (P<0.001). The correlations were inverse or not significant in the whole sample. The following variables correlated significantly with a high BF% (r (s)=+/-0.2): a low intake of milk in both girls and boys, a high intake of fibre and alcohol and a low intake of sugar in girls and a low intake of breakfast cereals in boys. Those with regular breakfast habits had healthier food choices than others, but this was not related to BF%. Boys had more meals per day (4.9 vs 4.6, P=0.02), especially early in the morning and late at night, whereas girls reported a higher relative intake of light meals and fruit and a lower intake of milk than boys. CONCLUSIONS: A few associations between eating habits and body fatness were found, but without any obvious patterns. The true differences in eating habits between lean and overweight adolescents are probably very small.
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| 40. |
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| 41. |
- Verstraeten, A., et al.
(author)
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Effects of tree pollen on throughfall element fluxes in European forests
- 2023
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In: Biogeochemistry. - Göteborg : Springer. - 0168-2563 .- 1573-515X. ; 165:3, s. 311-325
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Journal article (peer-reviewed)abstract
- The effects of tree pollen on precipitation chemistry are not fully understood and this can lead to misinterpretations of element deposition in European forests. We investigated the relationship between forest throughfall (TF) element fluxes and the Seasonal Pollen Integral (SPIn) using linear mixed-effects modelling (LME). TF was measured in 1990-2018 during the main pollen season (MPS, arbitrary two months) in 61 managed, mostly pure, even-aged Fagus, Quercus, Pinus, and Picea stands which are part of the ICP Forests Level II network. The SPIn for the dominant tree genus was observed at 56 aerobiological monitoring stations in nearby cities. The net contribution of pollen was estimated as the TF flux in the MPS minus the fluxes in the preceding and succeeding months. In stands of Fagus and Picea, two genera that do not form large amounts of flowers every year, TF fluxes of potassium (K+), ammonium-nitrogen (NH4+-N), dissolved organic carbon (DOC), and dissolved organic nitrogen (DON) showed a positive relationship with SPIn. However- for Fagus- a negative relationship was found between TF nitrate-nitrogen (NO3--N) fluxes and SPIn. For Quercus and Pinus, two genera producing many flowers each year, SPIn displayed limited variability and no clear association with TF element fluxes. Overall, pollen contributed on average 4.1-10.6% of the annual TF fluxes of K+ > DOC > DON > NH4+--N with the highest contribution in Quercus > Fagus > Pinus > Picea stands. Tree pollen appears to affect TF inorganic nitrogen fluxes both qualitatively and quantitatively, acting as a source of NH4+--N and a sink of NO3--N. Pollen appears to play a more complex role in nutrient cycling than previously thought.
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