| 1. |
|
|
| 2. |
- Yoo, S. J. B., et al.
(author)
-
Spectral phase encoded time spread optical code division multiple access technology for next generation communication networks Invited
- 2007
-
In: Journal of Optical Networking. - 1536-5379. ; 6:10, s. 1210-1227
-
Journal article (peer-reviewed)abstract
- We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/s (32-user x 10 Gbit/s) all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral efficiency at 100% and above. In particular, InP-based integrated photonics allows implementation of SPECTS O-CDMA transmitters and receivers monolithically integrated on a chip. The integrated InP chip technology not only allows robust and compact configurations for practical and low-cost O-CDMA network deployments but also offers code reconfigurations at rapid rates for secure communication applications.
|
|
| 3. |
|
|
| 4. |
- Klionsky, Daniel J., et al.
(author)
-
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- 2008
-
In: Autophagy. - : Landes Bioscience. - 1554-8627 .- 1554-8635. ; 4:2, s. 151-175
-
Research review (peer-reviewed)abstract
- Research in autophagy continues to accelerate,1 and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.2,3 There are many useful and convenient methods that can be used to monitor macroautophagy in yeast, but relatively few in other model systems, and there is much confusion regarding acceptable methods to measure macroautophagy in higher eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers of autophagosomes versus those that measure flux through the autophagy pathway; thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from fully functional autophagy that includes delivery to, and degradation within, lysosomes (in most higher eukaryotes) or the vacuole (in plants and fungi). Here, we present a set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes. This set of guidelines is not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response.
|
|
| 5. |
- Soares, Francisco M., et al.
(author)
-
Monolithic InP 100-Channel X 10-GHz Device for Optical Arbitrary Waveform Generation
- 2011
-
In: IEEE Photonics Journal. - 1943-0655. ; 3:6, s. 975-985
-
Journal article (peer-reviewed)abstract
- We demonstrate monolithic integration of a 100-channel arrayed-waveguide grating (AWG) with 10-GHz channel spacing and 100 optically controlled Michelson-interferometer-based phase and amplitude modulators. The high-resolution AWG showed better than -15-dB crosstalk, and the modulator extinction ratio was better than 20 dB with either electrical or optical modulation control. The twin-integrated devices comprise a 50-mm diameter InP wafer with 1200 independent optoelectronic components.
|
|
| 6. |
|
|
| 7. |
- Robinette, Michelle L., et al.
(author)
-
Association of Somatic TET2 Mutations With Giant Cell Arteritis
- 2024
-
In: Arthritis and Rheumatology. - 2326-5191. ; 76:3, s. 438-443
-
Journal article (peer-reviewed)abstract
- Objective: Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified an association between GCA and hematologic malignancies (HMs). How the presence of somatic mutations that drive the development of HMs, or clonal hematopoiesis (CH), may influence clinical outcomes in GCA is not well understood. Methods: To examine an association between CH and GCA, we analyzed sequenced exomes of 470,960 UK Biobank (UKB) participants for the presence of CH and used multivariable Cox regression. To examine the clinical phenotype of GCA in patients with and without somatic mutations across the spectrum of CH to HM, we performed targeted sequencing of blood samples and electronic health record review on 114 patients with GCA seen at our institution. We then examined associations between specific clonal mutations and GCA disease manifestations. Results: UKB participants with CH had a 1.48-fold increased risk of incident GCA compared to UKB participants without CH. GCA risk was highest among individuals with cytopenia (hazard ratio [HR] 2.98, P = 0.00178) and with TET2 mutation (HR 2.02, P = 0.00116). Mutations were detected in 27.2% of our institutional GCA cohort, three of whom had HM at GCA diagnosis. TET2 mutations were associated with vision loss in patients with GCA (odds ratio 4.33, P = 0.047). Conclusions: CH increases risk for development of GCA in a genotype-specific manner, with the greatest risk being conferred by the presence of mutations in TET2. Somatic TET2 mutations likewise increase the risk of GCA-associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future.
|
|
| 8. |
|
|
| 9. |
- Takano, Y., et al.
(author)
-
The single-scattering properties of black carbon aggregates determined from the geometric-optics surface-wave approach and the T-matrix method
- 2013
-
In: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier BV. - 0022-4073. ; 125, s. 51-56
-
Journal article (peer-reviewed)abstract
- The single-scattering properties of eight black carbon (BC, soot) fractal aggregates, composed of primary spheres from 7 to 600, computed by the geometric-optics surface-wave (GOS) approach coupled with the Rayleigh-Gans-Debye (RGD) adjustment for size parameters smaller than approximately 2, are compared with those determined from the superposition T-matrix method. We show that under the condition of random orientation, the results from GOS/RGD are in general agreement with those from T-matrix in terms of the extinction and absorption cross-sections, the single-scattering co-albedo, and the asymmetry factor. When compared with the specific absorption (m(2)/g) measured in the laboratory, we illustrate that using the observed radii of primary spheres ranging from 3.3 to 25 nm, the theoretical values determined from GOS/RGD for primary sphere numbers of 100-600 are within the range of measured values. The GOS approach can be effectively applied to aggregates composed of a large number of primary spheres (e.g., > 6000) and large size parameters (>> 2) in terms of computational efforts.
|
|
