| 1. |
- Hudson, Thomas J., et al.
(author)
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International network of cancer genome projects
- 2010
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Journal article (peer-reviewed)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 2. |
- Sang, Shaowei, et al.
(author)
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The epidemiological characteristics of dengue in high-risk areas of China, 2013-2016
- 2021
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In: PLoS Neglected Tropical Diseases. - : Public Library of Science. - 1935-2727 .- 1935-2735. ; 15:12
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Journal article (peer-reviewed)abstract
- Introduction: Dengue has become a more serious human health concern in China, with increased incidence and expanded outbreak regions. The knowledge of the cross-sectional and longitudinal epidemiological characteristics and the evolutionary dynamics of dengue in high-risk areas of China is limited.Methods: Records of dengue cases from 2013 to 2016 were obtained from the China Notifiable Disease Surveillance System. Full envelope gene sequences of dengue viruses detected from the high-risk areas of China were collected. Maximum Likelihood tree and haplotype network analyses were conducted to explore the phylogenetic relationship of viruses from high-risk areas of China.Results: A total of 56,520 cases was reported in China from 2013 to 2016. During this time, Yunnan, Guangdong and Fujian provinces were the high-risk areas. Imported cases occurred almost year-round, and were mainly introduced from Southeast Asia. The first indigenous case usually occurred in June to August, and the last one occurred before December in Yunnan and Fujian provinces but in December in Guangdong Province. Seven genotypes of DENV 1-3 were detected in the high-risk areas, with DENV 1-I the main genotype and DENV 2-Cosmopolitan the secondary one. The Maximum Likelihood trees show that almost all the indigenous viruses separated into different clusters. DENV 1-I viruses were found to be clustered in Guangdong Province, but not in Fujian and Yunnan, from 2013 to 2015. The ancestors of the Guangdong viruses in the cluster in 2013 and 2014 were most closely related to strains from Thailand or Singapore, and the Guangdong virus in 2015 was most closely related to the Guangdong virus of 2014. Based on closest phylogenetic relationships, viruses from Myanmar possibly initiated further indigenous cases in Yunnan, those from Indonesia in Fujian, while viruses from Thailand, Malaysia, Singapore and Indonesia were predominant in Guangdong Province.Conclusions: Dengue is still an imported disease in China, although some genotypes continued to circulate in successive years. Viral phylogenies based on the envelope gene suggested periodic introductions of dengue strains into China, primarily from Southeast Asia, with occasional sustained, multi-year transmission in some regions of China.Author summary: Dengue is the most prevalent and rapidly spreading mosquito-borne viral disease globally. Because of the multiple introductions, dengue outbreaks occurred in epidemic seasons in Southern China, supported by suitable weather conditions. Surveillance data from 2013 to 2016 in China showed that Guangdong, Yunnan and Fujian provinces were the high-risk areas, with dengue outbreaks occurring almost every year. However, knowledge has been lacking of the epidemiological characteristics and the evolution pattern of dengue virus in these high-risk areas. This study shows a variety of epidemiological characteristics and sources of imported cases among the high-risk areas in China, with likely origins primarily from countries in Southeast Asia. Seven genotypes of the DENV 1-3 variety co-circulated with DENV1-I, the main genotype, and DENV 2-Cosmopolitan, the secondary. Genetic relationships among viral strains suggest that the indigenous viruses in the high-risk areas arose from imported viruses and sometimes persisted between years into the next epidemic season, especially in Guangdong Province. Population movement has played a vital role in dengue epidemics in China. This information may be useful in dengue control, especially during epidemic seasons and in the development of an early warning system within the region, in collaboration with bordering countries.
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| 3. |
- Sang, Shaowei, et al.
(author)
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The evolutionary dynamics of DENV 4 genotype I over a 60-year period
- 2019
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In: PLoS Neglected Tropical Diseases. - : Public Library of Science. - 1935-2727 .- 1935-2735. ; 13:7
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Journal article (peer-reviewed)abstract
- Dengue virus serotype 4 (DENV 4) has had a relatively low prevalence worldwide for decades; however, likely due to data paucity, no study has investigated the epidemiology and evolutionary dynamics of DENV 4 genotype I (DENV 4-I). This study aims to understand the diversity, epidemiology and dynamics of DENV 4-I. We collected 404 full length DENV4-1 envelope (E) gene sequences from 14 countries using two sources: Yunnan Province in China (15 strains during 2013-2016) and GenBank (489 strains up to 2018-01-11). Conducting phylogenetic and phylogeographical analyses, we estimated the virus spread, population dynamics, and selection pressures using different statistical analysis methods (substitution saturation, likelihood mapping, Bayesian coalescent inference, and maximum likelihood estimation). Our results show that during the last 60 years (1956-2016), DENV 4-I was present in mainland and maritime Southeast Asia, the Indian subcontinent, the southern provinces of China, parts of Brazil and Australia. The recent spread of DENV 4-I likely originated in the Philippines and later spread to Thailand. From Thailand, it spread to adjacent countries and eventually the Indian subcontinent. Apparently diverging around years 1957, 1963, 1976 and 1990, the different Clades (Clade I-V) were defined. The mean overall evolution rate of DENV 4-I was 9.74 (95% HPD: 8.68-10.82) x 10(-4) nucleotide substitutions/site/year. The most recent common ancestor for DENV 4-I traces back to 1956. While the demographic history of DENV 4-I fluctuated, peaks appeared around 1982 and 2006. While purifying selection dominated the majority of E-gene evolution of DENV 4-I, positive selection characterized Clade III (Vietnam). DENV 4-I evolved in situ in Southeast Asia and the Indian subcontinent. Thailand and Indian acted as the main and secondary virus distribution hubs globally and regionally. Our phylogenetic analysis highlights the need for strengthened regional cooperation on surveillance and sharing of sample sequences to improve global dengue control and cross-border transmission prevention efforts. Author summary Dengue virus (DENV) can be classified into four serotypes, DENV 1, 2, 3 and 4. Although DENV 4 is the first dengue serotype to diverge in phylogenetic analyses of the genus Flavivirus, this serotype occurs at a low prevalence worldwide and spreads the least rapidly. Similar to other serotypes, DENV 4 can also cause severe dengue (SD) disease manifestations, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). To date, no study has investigated the epidemiology and dynamics of DENV 4 genotype I comprehensively. In this study, we seek to address this gap. Our study shows that the distribution of DENV 4-I is mainly restricted to Southeast Asia and the Indian subcontinent. The most recent spread of DENV 4-I likely originated from Southeast Asia-initially circulating in the Philippines, then Thailand and later on the Indian subcontinent. Viruses evolved in situ in Southeast Asia and the Indian subcontinent, respectively. Although DENV 4-I occasionally spread elsewhere, this genotype did not become widely established. The overall evolution rate of DENV 4-I was comparable with that of DENV 2-4. The nucleotide sequences indicates that the demographic history of DENV 4-I fluctuated with peaks apparent during parts of the 1980s and 2000s. Although a weak positive selection existed in Clade III -predominately in Vietnam, purifying selection dominated the E-gene evolution of DENV 4-I.
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| 4. |
- Baber, Ashleigh E., et al.
(author)
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Stabilization of Catalytically Active Cu plus Surface Sites on TitaniumCopper Mixed-Oxide Films**
- 2014
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In: Angewandte Chemie International Edition. - : Gesellschaft Deutscher Chemiker. - 1433-7851 .- 1521-3773. ; 53:21, s. 5336-5340
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Journal article (peer-reviewed)abstract
- The oxidation of CO is the archetypal heterogeneous catalytic reaction and plays a central role in the advancement of fundamental studies, the control of automobile emissions, and industrial oxidation reactions. Copper-based catalysts were the first catalysts that were reported to enable the oxidation of CO at room temperature, but a lack of stability at the elevated reaction temperatures that are used in automobile catalytic converters, in particular the loss of the most reactive Cu+ cations, leads to their deactivation. Using a combined experimental and theoretical approach, it is shown how the incorporation of titanium cations in a Cu2O film leads to the formation of a stable mixed-metal oxide with a Cu+ terminated surface that is highly active for CO oxidation.
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| 5. |
- Li, Xiaofang, et al.
(author)
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Roles of Acceptor Guests in Tuning the Organic Solar Cell Property Based on an Efficient Binary Material System with a Nearly Zero Hole-Transfer Driving Force
- 2020
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In: Chemistry of Materials. - : AMER CHEMICAL SOC. - 0897-4756 .- 1520-5002. ; 32:12, s. 5182-5191
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Journal article (peer-reviewed)abstract
- Sub-picosecond hole transfer has been recently observed in several narrow band gap nonfullerene small-molecule acceptor (NFA)-based binary blended organic solar cell (OSC) systems operating with negligible energetic driving forces. As the driving forces are near zero, how the added acceptor/donor guests tune the barrier-free hole-transfer dynamics of these systems remains very unclear. In this study, we report a new NFA (BTCT-2Cl) that conducts a sub-picosecond hole transfer (2 ps) for efficient photocurrent generation when pairing with PM6 though the energetic offset is only 0.02 eV. We observe that the added nonfullerene and PCBM components differently tune the charge generation and recombination when selectively exciting BTCT-2Cl. After adding PC71BM, the hole transfer from the host BTCT-2Cl to the host donor is greatly accelerated, with the rate significantly reduced to 0.29 ps and the charge generation becomes more efficient; on the contrary, recombination is prolonged and a larger fill factor is obtained after adding an NFA guest, here, IT-4F. The different tuning on the host binary hole-transfer dynamics is likely related with the phase crystallinity and the domain size changed after adding different acceptor guests. Over 16% efficiency is obtained on the PC71BM-based ternary device that outperforms the host binary and the IT-4F-based ternary solar cells (both showing over 15% efficiencies). The results clearly demonstrate that adding PCBM or NFA guests enables a very effective and different tuning on the hole-transfer rates and the recombination rates between the barrier-free host binary components, hence leading to efficient tuning on the short-circuit current density and fill factor, which outlines new strategies toward designing high-efficiency ternary blended OSC systems.
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| 6. |
- Li, Zongbao, et al.
(author)
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High throughput trapping and arrangement of biological cells using self-assembled optical tweezer
- 2018
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In: Optics Express. - : OPTICAL SOC AMER. - 1094-4087. ; 26:26, s. 34665-34674
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Journal article (peer-reviewed)abstract
- Lately, a fiber-based optical tweezer that traps and arranges the micro/nanoparticles is crucial in practical applications, because such a device can trap the biological samples and drive them to the designated position in a microfluidic system or vessel without harming them. Here, we report a new type of fiber optical tweezer, which can trap and arrange erythrocytes. It is prepared by coating graphene on the cross section of a microfiber. Our results demonstrate that thermal-gradient-induced natural convection flow and thermophoresis can trap the erythrocytes under low incident power, and the optical scattering force can arrange them precisely under higher incident power. The proposed optical tweezer has high flexibility, easy fabrication, and high integration with lab-on-a-chip, and shows considerable potential for application in various fields, such as biophysics, biochemistry, and life sciences.
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| 7. |
- Li, Zongbao, et al.
(author)
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Upconversion Luminescence of Graphene Oxide through Hybrid Waveguide
- 2018
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In: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 122:29, s. 16866-16871
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Journal article (peer-reviewed)abstract
- Phonon-assisted upconversion is a promising way to generate short-wavelength emissions under excitation of long wavelength based on unique anti-Stokes luminescence properties. Graphene oxide nanosheets (GONs) exhibit excellent optical properties owing to quantum confinement and edge effects, which have driven research into fundamental principles and potential applications. Here, we experimentally demonstrate upconversion emission by exciting an easily fabricated GON hybrid waveguide (GHVV) with enhanced photothermal effects. The results reveal different origins of short-wavelength range and long-wavelength range in the upconversion spectra, whereas the emissive surface defects of GONs and GHW structure play significant roles in the behavior of photoluminescence. Introducing other upconversion materials to promote emission efficiency, the hybrid waveguide system might readily provide the possibility for the construction of upconversion fiber lasers and remote control of the upconversion luminescence.
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| 8. |
- Yang, Qinli, et al.
(author)
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A generic framework to analyse the spatiotemporal variations of water quality data on a catchment scale
- 2019
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In: Environmental Modelling and Software. - : Elsevier BV. - 1364-8152. ; 122
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Journal article (peer-reviewed)abstract
- Most spatiotemporal studies treat spatial and temporal analysis separately. However, spatial and temporal changes occur simultaneously and are correlated. In this study, we propose a generic framework to simultaneously analyse the spatial and temporal variations of water quality on a catchment scale. Specifically, we analyse the heterogeneity of temporal evolution of water quality data among different sampling sites, and the heterogeneity of spatial distribution of water quality data over different sampling times, respectively, by integrating the techniques of normalized mutual information, dynamic time wrapping and cluster analysis. To bring deep insight into the spatiotemporal variations, inter-change and intra-change are further defined and distinguished, respectively. Taking the Fuxi River catchment as a case study, results indicate that the proposed framework is intuitive and efficient. Beyond this, the generic framework can be expanded for other catchments and various environmental data.
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| 9. |
- Yang, Xiaofang, et al.
(author)
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Application of ATR-FTIR spectroscopy in the study of adsorption on environmental micro-interfaces
- 2010
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In: Huaxue jinzhan. - 1005-281X. ; 22:6, s. 1185-1194
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Journal article (peer-reviewed)abstract
- Interfacial adsorption process is the initial step or key step for most of environmental micro-interface reactions. The online study of environmental micro-interfacial adsorption by in situ research methods provides direct information about interface reactions and reliable evidence for the detection of reaction mechanisms which are of great importance to understand the rule of transformation and distribution of pollutants in the environment. Because of its unique sampling principle, convenient sample pre-treatment and wide applicability, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) is becoming a powerful tool for investigating the interface reactions. Based on a brief introduction of the working principle of ATR-FTIR, the application of this technique in the investigation of adsorption on environmental interfaces, especially mineral-water interfaces, is summarized. Furthermore, the perspective of this method is discussed as well.
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| 10. |
- Ye, Chiyu, et al.
(author)
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A preliminary analysis of the effect of the new rural cooperative medical scheme on inpatient care at a county hospital
- 2013
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In: BMC Health Services Research. - : BioMed Central. - 1472-6963. ; 13:519, s. 1-8
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Journal article (peer-reviewed)abstract
- Background: China in 2009 committed to reach universal health coverage by promoting three forms of health insurance; NCMS for the rural population, UEBMI for formally employed urban residents and URBMI for other urban residents. NCMS has expanded to near universal coverage in rural China since launching in 2003. The objective of this study aimed to assess the effect of NCMS on inpatient care utilization from 2003 to 2012 at Longyou county hospital, Zhejiang province.Methods: The research was conducted at Longyou county, Zhejiang province. All registered inpatient admissions from January 1, 2003, to June 30, 2012, were included in the study. The PLSQL Developer software was used toselect the interesting variables in the hospital information database and saved in an Excel 2003 file. The interesting variables included the patients’ general information (name, gender, age, payment method), discharge diagnosis, length of hospital stay, and expenditure (total expenditure and out-of-pocket payment). Two common diseases (coronary arteriosclerotic disease and pneumonia) were selected as tracer conditions.Results: 292,400 rural residents were enrolled in the Longyou county NCMS by 2011, 95.4% of the eligible population. A total of 145,744 inpatient admissions were registered from 1 January 2003 to 30 June 2012. The proportion ofinpatients covered by NCMS increased from 30.3% in 2004 to 54.2% in 2012 while the proportion of inpatients covered by UEBMI increased from 7.7% in 2003 to 14.7% in 2012. The average expenditure for UEBMI insured inpatients washigher than the average for NCMS insured inpatients, although the gap was narrowing. The average length of hospitalstay increased every year for all inpatients, but was higher for UEBMI inpatients than for NCMS insured inpatients. For both tracer conditions the results were similar to the above findings.Conclusions: NCMS has improved coverage height for its enrollees and resulted in increased cost of care per inpatient admission at the county hospital. However, wide differences persist between the two insurance systems in coverage height. Both systems are associated with increasing lengths of stay and rising cost per inpatient admission. We found that around 30% of inpatients were not covered by any of the two public health insurance systems, which calls for further studies.
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| 11. |
- Zhang, Yinlong, et al.
(author)
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GCMVF-AGV : Globally Consistent Multiview Visual-Inertial Fusion for AGV Navigation in Digital Workshops
- 2023
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In: IEEE Transactions on Instrumentation and Measurement. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9456 .- 1557-9662. ; 72
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Journal article (peer-reviewed)abstract
- An accurate and globally consistent navigation system is crucial for estimating the positions and attitudes of automated guided vehicles (AGVs) in digital workshops. A promising navigation technology for this purpose is tightly coupled visual-inertial fusion, which offers advantages such as quick response (QR), absolute scale, and accuracy. However, existing visual-inertial fusion systems have limitations, including long-term drift, tracking failures in textureless or poorly illuminated environments, and a lack of absolute references. To create a reliable and consistent AGV navigation framework and correct for long-term drift, we have designed a novel framework, globally consistent multiview visual-inertial fusion for AGV navigation (GCMVF-AGV). This framework uses a downward-looking QR vision sensor and a forward-looking visual-inertial sensor together to estimate AGV poses in real time. The downward camera provides absolute AGV positions and attitudes with reference to the global workshop frame. Furthermore, long-term visual-inertial drift, inertial biases, and velocities are periodically compensated between spatial intervals of QR codes by minimizing visual-inertial residuals with the rigid constraints of absolute poses estimated from the downward visual measurements. We have evaluated the proposed method on the developed AGV navigation platform, and experimental results demonstrate the position and attitude errors of less than 0.05 m and 2 degrees, respectively.
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