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Search: WFRF:(Liu Yuexin)

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1.
  • Weinstein, John N., et al. (author)
  • The cancer genome atlas pan-cancer analysis project
  • 2013
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
  • Research review (peer-reviewed)abstract
    • The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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2.
  • Berger, Ashton C, et al. (author)
  • A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
  • 2018
  • In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:4, s. 690-705.e9
  • Journal article (peer-reviewed)abstract
    • We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.
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3.
  • Cao, Yuexin, et al. (author)
  • Minimal Control Placement of Turing's Model Using Symmetries
  • 2023
  • In: 2023 62nd IEEE Conference on Decision and Control, CDC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 1456-1461
  • Conference paper (peer-reviewed)abstract
    • In this paper, the minimal control placement prob-lem for Turing's reaction-diffusion model is studied. Turing's model describes the process of morphogens diffusing and reacting with each other and is considered as one of the most fundamental models to explain pattern formation in a devel-oping embryo. Controlling pattern formation artificially has gained increasing attention in the field of development biology, which motivates us to investigate this problem mathematically. In this work, the two-dimensional Turing's reaction-diffusion model is discretized into square grids. The minimal control placement problem for the diffusion system is investigated first. The symmetric control sets are defined based on the symmetry of the network structure. A necessary condition is provided to guarantee controllability. Under certain circumstances, we prove that this condition is also sufficient. Then we show that the necessary condition can also be applied to the reaction-diffusion system by means of suitable extension of the symmetric control sets. Under similar circumstances, a sufficient condition is given to place the minimal control for the reaction-diffusion system.
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  • Result 1-4 of 4

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