| 1. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(author)
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- 2021
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| 5. |
- Thomas, HS, et al.
(author)
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- 2019
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| 6. |
- Glasbey, JC, et al.
(author)
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- 2021
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| 10. |
- Khatri, C, et al.
(author)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 16. |
- Campbell, PJ, et al.
(author)
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Pan-cancer analysis of whole genomes
- 2020
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Journal article (peer-reviewed)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 23. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 33. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 40. |
- Wang, HD, et al.
(author)
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Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
- 2016
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In: Lancet (London, England). - : Elsevier. - 1474-547X .- 0140-6736. ; 388:10053, s. 1725-1774
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Journal article (peer-reviewed)
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| 41. |
- Abdallah, J, et al.
(author)
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A precise measurement of the B+, B-0 and mean b-hadron lifetime with the DELPHI detector at LEP I
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:3, s. 307-324
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Journal article (peer-reviewed)abstract
- Final results from the DELPHI Collaboration on the lifetime of B+ and B-0 mesons and the mean b-hadron lifetime, are presented using the data collected at the Z(0) peak in 1994 and 1995. Elaborate, inclusive, secondary vertexing methods have been employed to ensure a b-hadron reconstruction with good efficiency. To separate samples of B+ and B-0 mesons, high performance neural network techniques are used that achieve very high purity signals. The results obtained are: tau(B+) = 1.624+/-0.014 (stat)+/-0.018 (syst) ps tau(B)0 = 1.531+/-0.021 (stat)+/-0.031 (syst) ps tau(B+)/tau(B)0 = 1.060+/-0.021 (stat)+/-0.024 (syst) and for the average b-hadron lifetime: taub/tau(B)0 = 1.570+/-0.005 (stat)+/-0.008 (syst) ps.
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| 42. |
- Abdallah, J, et al.
(author)
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A precise measurement of the tau lifetime
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 36:3, s. 283-296
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Journal article (peer-reviewed)abstract
- The tau lepton lifetime has been measured with the e(+) e(-) --> tau(+) tau(-) events collected by the DELPHI detector at LEP in the years 1991 - 1995. Three different methods have been exploited, using both one-prong and three-prong tau decay channels. Two measurements have been made using events in which both taus decay to a single charged particle. Combining these measurements gave tau(tau) ( 1 prong) = 291.8 +/- 2.3(stat) +/- 1.5(sys) fs. A third measurement using taus which decayed to three charged particles yielded tau(tau) (3 prong) = 288.6 +/- 2.4(stat) +/- 1.3(sys) fs. These were combined with previous DELPHI results to measure the tau lifetime, using the full LEP1 data sample, to be tau(tau) = 290.9 +/- 1.4(stat) +/- 1.0(sys) fs.
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| 43. |
- Abdallah, J, et al.
(author)
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Determination of heavy quark non-perturbative parametersfrom spectral moments in semileptonic B decays
- 2006
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 45:1, s. 35-59
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Journal article (peer-reviewed)abstract
- Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distribution, have been used to determine parameters which enter into the extraction of vertical bar V-cb vertical bar from the measurement of the inclusive b-hadron semileptonic decay width. The values obtained in the kinetic scheme are: m(b)(1 GeV) = 4.591 +/- 0.062 +/- 0.039 +/- 0.005 GeV/c(2), m(c)(1 GeV) = 1.170 +/- 0.093 +/- 0.055 +/- 0.005 GeV/c(2), m(pi)(2) (1 GeV) = 0.399 +/- 0.048 +/- 0.034 +/- 0.087 GeV2, (p) over tilde (3)(D) = 0.053 +/- 0.017 +/- 0.011 +/- 0.026 GeV3, and include corrections at order 1/m(b)(3). Using these results, and present measurements of the inclusive semileptonic decay partial width of b-hadrons at LEP, an accurate determination of vertical bar V-cb vertical bar is obtained: vertical bar V-cb vertical bar = 0.0421 x (1 +/- 0.014 (meas center dot) +/- 0.014 (fit) +/- 0.015 (th center dot)).
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| 44. |
- Abdallah, J, et al.
(author)
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Determination of the e(+)e(-)->gamma gamma(gamma) cross-section at LEP 2
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 37:4, s. 405-419
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Journal article (peer-reviewed)abstract
- A test of the benchmark QED process e(+) e(-) -->gammagamma(gamma) is reported, using the data collected with the DELPHI detector at LEP 2. The data analysed were recorded at centre-of-mass energies ranging from 161 GeV to 208 GeV and correspond to a total integrated luminosity of 656.4 pb(-1). The Born cross-section for the process e(+) e(-)-->gammagamma(gamma) was determined, confirming the validity of QED at the highest energies ever attained in electron-positron collisions. Lower limits on the parameters of a number of possible deviations from QED, predicted within theoretical frameworks expressing physics beyond the Standard Model, were derived.
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| 45. |
- Abdallah, J, et al.
(author)
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Measurement of the energy dependence of hadronic jet rates and the strong coupling alpha(s) from the four-jet rate with the DELPHI detector at LEP
- 2005
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 413-426
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Journal article (peer-reviewed)abstract
- Hadronic events from the data collected with the DELPHI detector at LEP within the energy range from 89 GeV to 209 GeV are selected, their jet rates are determined and compared to predictions of four different event generators. One of them is the recently developed APACIC++ generator which performs a massive matrix element calculation matched to a parton shower followed by string fragmentation. The four-jet rate is used to measure alpha(s) in the next-to-leading-order approximation yielding alpha(s)(M-Z(2)) = 0.1175 +/- 0.0030. The running of alpha(s) determined by using four-jet events has been tested. The logarithmic energy slope is measured to be dalpha(s)(-1)/d log E-cm = 1.14 +/- 0.36. Since the analysis is based on four-jet final states it represents an alternative approach to previous DELPHI alpha(s) measurements using event shape distributions.
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| 46. |
- Abdallah, J, et al.
(author)
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Measurement of the forward-backward asymmetries of e(+)e(-)-> Z -> b(b)over-bar and e(+)e(-)-> Z -> c(c)over-bar using prompt leptons
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 109-125
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Journal article (peer-reviewed)abstract
- The forward-backward asymmetries of the processes e(+) e(-) --> Z --> b (b) over bar and e(+)e(-) --> Z --> c (c) over bar were measured from a sample of hadronic Z decays collected by the DELPHI experiment between 1993 and 1995. Enriched samples of b (b) over bar and c (c) over bar events were obtained using lifetime information. The tagging of b and c quarks in these samples was based on the semileptonic decay channels b/c --> X + mu and b/c --> X + e combined with charge flow information from the hemisphere opposite to the lepton. Combining the A(FB)(b (b) over bar) and A(FB)(c (c) over bar) measurements presented in this paper with published results based on 1991 and 1992 DELPHI data samples, the following pole asymmetries were obtained: A(FB)(0,b) = 0.1021 +/- 0.0052 (stat) +/- 0.0024 (syst) A(FB)(0,c) = 0.0728 +/- 0.0086 (stat) +/- 0.0063 (syst) The effective value of the weak mixing angle derived from these measurements is sin(2) theta(W,eff)(lept) = 0.23170 +/- 0.00097.
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| 47. |
- Abdallah, J, et al.
(author)
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Measurement of the W-pair production cross-section and W branching ratios in e(+)e(-) collisions at root s=161-209 GeV
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 127-144
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Journal article (peer-reviewed)abstract
- These final results on e(+) e(-) W+ W- production cross-section measurements at LEP2 use data collected by the DELPHI detector at centre-of-mass energies up to 209 GeV. Measurements of total cross-sections, W angular differential distributions and decay branching fractions, and the value of the CKM element |V-cs| are compared to the expectations of the Standard Model. These results supersede all values previously published by DELPHI.
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| 48. |
- Abdallah, J, et al.
(author)
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Measurement of vertical bar Vcb vertical bar using the semileptonic decay (B)d(0))over-bar -> D*+l(-)(nu)over-barl
- 2004
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:2, s. 213-232
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Journal article (peer-reviewed)abstract
- Data from Z decays in DELPHI have been searched for <(B-d(o))over bar> --> D*+ l(-) (ν) over bar (l) with the D*+ decaying to D(0)pi(+) and D-0 --> K(-)pi(+), K(-)pi(+)pi(+)pi(-) or K- pi(+)(pi(0)). These events are used to measure the CKM matrix element V-cb and the form factor slope, rho(A1)(2): F-D*(1) V-cb = 0.0392 +/- 0.0018 +/- 0.0023; rho(A1)(2) = 1.32 +/- 0.15 +/- 0.33 corresponding to a branching fraction: BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.90 +/- 0.22 +/- 0.50)%. Combining these and previous DELPHI measurements gives: FD*(1)V-cb = 0.0377 +/- 0.0011 +/- 0.0019, rho(A1)(2) = 1.39 +/- 0.10 +/- 0.33 and BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.39 +/- 0.11 +/- 0.34)% Using F-D*(1) = 0.91 +/- 0.04, yields: V-cb = 0.0414 +/- 0.0012(stat.) +/- 0.0021(syst.) +/- 0.0018 (theory). The b-quark semileptonic branching fraction into a D*+ emitted from higher mass charmed excited states has also been measured to be: BR(b --> D*+ Xl(-)(ν) over bar (l)) = (0.67 +/- 0.08 +/- 0.10)%.
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| 49. |
- Abdallah, J, et al.
(author)
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Photon events with missing energy in e(+)e(-) collisions at root s=130 to 209 GeV
- 2005
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 395-411
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Journal article (peer-reviewed)abstract
- The production of single- and multi-photon events has been studied in the reaction e(+) e(-) --> gamma(gamma) + invisible particles. The data collected with the DELPHI detector during the years 1999 and 2000 at centre-of-mass energies between 191 GeV and 209 GeV was combined with earlier data to search for phenomena beyond the Standard Model. The measured number of light neutrino families was consistent with three and the absence of an excess of events beyond that predicted by the Standard Model processes was used to set limits on new physics. Both model-independent searches and searches for new processes predicted by supersymmetric and extra-dimensional models have been made. Limits on new non-standard model interactions between neutrinos and electrons were also determined.
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| 50. |
- Abdallah, J, et al.
(author)
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Search for B-s(0)-(B-s(0))over-bar oscillations in DELPHI using high-p(t) leptons
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:1, s. 35-52
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Journal article (peer-reviewed)abstract
- Oscillations in the B-s(0)- <(B-s(0))over bar> system were studied in events selected from about 4.3 million hadronic Z(0) decays registered by DELPHI between 1992 and 2000. This paper presents updates of two published analyses ([11, 12]). The first analysis, which utilizes leptons emitted with large momentum transverse to a jet, was improved by means of a better algorithm for the vertex reconstuction and a new algorithm for flavour-tagging at production time. The second analysis, which utilizes D-s-lepton events, was improved by optimizing the treatment of proper time resolution. No signal of B-s(0) oscillations was observed and limits on the mass difference between the physical B-s(0) states were obtained to be: Deltam(s)>8.0 ps-1 at the 95% C.L. with a sensitivity of Deltam(s)= 9.1 ps(-1) in the high p(t) lepton analysis and Deltam(s)>4.9 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=8.6 ps(-1) in the D-s-lepton analysis. Previously published results on these analyses are superseded. The combination of these results with those obtained in other independent analyses previously performed in DELPHI (D-s-hadron, exclusive B-s(0), inclusive vertex) gives: Deltam(s)>8.5 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=12.0 ps(-1).
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