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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 12. |
- Ademuyiwa, Adesoji O., et al.
(author)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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In: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Journal article (peer-reviewed)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 13. |
- Aldridge, Jonathan, et al.
(author)
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Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis.
- 2022
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In: Clinical and experimental rheumatology. - : Clinical and Experimental Rheumatology. - 0392-856X .- 1593-098X. ; 40:7, s. 1393-1402
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Journal article (peer-reviewed)abstract
- In early rheumatoid arthritis (eRA) plasma levels of specific chemokines have been shown to correlate with disease activity. However, it is unclear whether pre-treatment chemokine levels can predict disease remission at week 24, and it is not known how biological treatments with different modes of action affect plasma chemokine levels in patients with untreated eRA.This study included 347 Swedish patients with untreated eRA from the larger NORD-STAR randomised treatment trial. Here, eRA patients were treated with methotrexate combined with either prednisolone, anti-TNF (certolizumab-pegol), CTLA-4Ig (abatacept) or anti-IL6 receptor (tocilizumab). The primary clinical outcome was remission by clinical disease activity index (CDAI) defined as CDAI ≤ 2.8. Disease activity was assessed by CDAI, DAS28-ESR, DAS28-CRP, swollen joint counts, tender joint counts, ESR and CRP. The plasma concentrations of 14 chemokines were measured at baseline and after 24 weeks of treatment by bead-based immunoassay or ELISA.Baseline plasma concentrations of CXCL10, CXCL8, CXCL9, CXCL11, CXCL5 and CCL2 correlated with baseline disease activity measures. After 24 weeks of treatment, plasma levels of CXCL10, CXCL8, CXCL9, CXCL11 and CXCL13 decreased in all treatment groups except in patients treated with anti-IL6 receptor. In multivariate factor analysis, plasma chemokine levels at baseline could not differentiate patients who attained remission by week 24 from those who did not in any of the treatment groups.In patients with untreated eRA, plasma levels of several chemokines correlate with disease activity at baseline but cannot predict remission after 24 weeks of treatment with methotrexate combined with prednisolone, anti‑TNF, CTLA‑4Ig or anti‑IL6R.
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| 14. |
- Barmark, Mimmi Maria, et al.
(author)
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Vem går det bättre för och varför?
- 2016
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In: Skolframgång i det mångkulturella samhället. - 9789144093529 ; , s. 65-84
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Book chapter (peer-reviewed)
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| 15. |
- Bergh, Anna, et al.
(author)
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A systematic review of complementary and alternative veterinary medicine : "miscellaneous therapies"
- 2021
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In: Animals. - : MDPI. - 2076-2615. ; 11:12
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Research review (peer-reviewed)abstract
- There is an increasing interest in complementary and alternative veterinary medicine (CAVM). There is, however, an uncertainty of the efficacy of these methods. Therefore, the aim of this systematic literature review is to assess the evidence for clinical efficacy of 24 CAVM therapies used in cats, dogs, and horses. A bibliographic search, restricted to studies in cats, dogs, and horses, was performed on Web of Science Core Collection, CABI, and PubMed. Relevant articles were assessed for scientific quality, and information was extracted on study characteristics, species, type of treatment, indication, and treatment effects. Of 982 unique publications screened, 42 were eligible for inclusion, representing nine different CAVM therapies, which were aromatherapy, gold therapy, homeopathy, leeches (hirudotherapy), mesotherapy, mud, neural therapy, sound (music) therapy, and vibration therapy. For 15 predefined therapies, no study was identified. The risk of bias was assessed as high in 17 studies, moderate to high in 10, moderate in 10, low to moderate in four, and low in one study. In those studies where the risk of bias was low to moderate, there was considerable heterogeneity in reported treatment effects. Therefore, the scientific evidence is not strong enough to define the clinical efficacy of the 24 CAVM therapies.
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| 16. |
- Bergh, Anna, et al.
(author)
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A Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals : Soft Tissue Mobilization
- 2022
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In: Animals. - : MDPI. - 2076-2615. ; 12:11
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Research review (peer-reviewed)abstract
- Soft tissue mobilization is frequently used in the treatment of sport and companion animals. There is, however, uncertainty regarding the efficacy and effectiveness of these methods. Therefore, the aim of this systematic literature review was to assess the evidence for clinical effects of massage and stretching in cats, dogs, and horses. A bibliographic search, restricted to studies in cats, dogs, and horses, was performed on Web of Science Core Collection, CABI, and PubMed. Relevant articles were assessed for scientific quality, and information was extracted on study characteristics, species, type of treatment, indication, and treatment effects. Of 1189 unique publications screened, 11 were eligible for inclusion. The risk of bias was assessed as high in eight of the studies and moderate in three of the studies, two of the latter indicating a decreased heart rate after massage. There was considerable heterogeneity in reported treatment effects. Therefore, the scientific evidence is not strong enough to define the clinical efficacy and effectiveness of massage and stretching in sport and companion animals.
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| 18. |
- Borgegard, Tomas, et al.
(author)
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Alzheimers Disease: Presenilin 2-Sparing gamma-Secretase Inhibition Is a Tolerable A beta Peptide-Lowering Strategy
- 2012
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In: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
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Journal article (peer-reviewed)abstract
- gamma-Secretase inhibition represents a major therapeutic strategy for lowering amyloid beta (A beta) peptide production in Alzheimers disease (AD). Progress toward clinical use of gamma-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The gamma-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between A beta production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1(PS1) over PS2 subclass of gamma-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain A beta levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious gamma-secretase targeting strategy for AD.
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| 19. |
- Borgegård, Tomas, et al.
(author)
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Alzheimer's Disease : Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
- 2012
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In: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 32:48, s. 17297-17305
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Journal article (peer-reviewed)abstract
- γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward clinical use of γ-secretase inhibitors has, however, been hampered due to mechanism-based adverse events, primarily related to impairment of Notch signaling. The γ-secretase inhibitor MRK-560 represents an exception as it is largely tolerable in vivo despite displaying only a small selectivity between Aβ production and Notch signaling in vitro. In exploring the molecular basis for the observed tolerability, we show that MRK-560 displays a strong preference for the presenilin 1 (PS1) over PS2 subclass of γ-secretases and is tolerable in wild-type mice but causes dose-dependent Notch-related side effect in PS2-deficient mice at drug exposure levels resulting in a substantial decrease in brain Aβ levels. This demonstrates that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provide preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious γ-secretase targeting strategy for AD.
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| 20. |
- Edvardsson, Johannes, et al.
(author)
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Water level impact on pine seedlings in greenhouse conditions : assessing growth and survival potential in ditched and managed peatlands
- 2024
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In: Scandinavian Journal of Forest Research. - 0282-7581 .- 1651-1891. ; 39:3-4, s. 199-210
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Journal article (peer-reviewed)abstract
- Tree establishment on peatlands has various adverse effects on the environment, with one of the most significant being their transformation from carbon sinks to carbon sources. This transformation has largely been instigated by economic-driven ditching initiatives. In this study, 80 peat-rooted pine seedlings were subjected to hydrological scenarios corresponding to natural, ditched, and rewetted conditions to investigate how different management strategies affect tree growth and survival. The study was conducted in a greenhouse where all plants were exposed to identical conditions except for the water level, and focused on factors like stomatal conductance, plant survival, length, biomass, and radial tree growth. Wet conditions, specifically treatments rewetted and natural, resulted in consistently lower stomatal conductance compared to drier treatments. Plant survival was affected, with 15 deaths in the rewetted and 2 in natural groups. Moreover, length, biomass, radial growth, and cell formation were significantly lower for the groups exposed to wet conditions. Rewetting can therefore effectively control tree colonisations, and thereby preventing water consumption, litter fertilisation, and other positive feedback effects for the trees that might be negative for the carbon uptake and biodiversity in peatlands. This study thereby offers valuable insights for rewetting initiatives in tree colonised peatland ecosystems.
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| 21. |
- Hellström, Ann, 1959, et al.
(author)
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Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity A Randomized Clinical Trial
- 2021
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In: JAMA Pediatrics. - : American Medical Association (AMA). - 2168-6203 .- 2168-6211. ; 175:4, s. 359-367
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Journal article (peer-reviewed)abstract
- IMPORTANCE Lack of arachidonic acid (AA) and docosahexaenoic acid (DHA) after extremely preterm birth may contribute to preterm morbidity, including retinopathy of prematurity (ROP). OBJECTIVE To determine whether enteral supplementation with fatty acids from birth to 40 weeks' postmenstrual age reduces ROP in extremely preterm infants. DESIGN, SETTING, AND PARTICIPANTS The Mega Donna Mega trial, a randomized clinical trial, was a multicenter study performed at 3 university hospitals in Sweden from December 15, 2016, to December 15, 2019. The screening pediatric ophthalmologists were masked to patient groupings. A total of 209 infants born at less than 27 weeks' gestation were tested for eligibility, and 206 infants were included. Efficacy analyses were performed on as-randomized groups on the intention-to-treat population and on the per-protocol population using as-treated groups. Statistical analyses were performed from February to April 2020. INTERVENTIONS Infants received either supplementation with an enteral oil providing AA (100mg/kg/d) and DHA (50mg/kg/d) (AA:DHA group) or no supplementation within 3 days after birth until 40 weeks' postmenstrual age. MAIN OUTCOMES AND MEASURES The primary outcomewas severe ROP (stage 3 and/or type 1). The secondary outcomes were AA and DHA serum levels and rates of other complications of preterm birth. RESULTS A total of 101 infants (58 boys [57.4%]; mean [SD] gestational age, 25.5 [1.5] weeks) were included in the AA:DHA group, and 105 infants (59 boys [56.2%]; mean [SD] gestational age, 25.5 [1.4] weeks) were included in the control group. Treatment with AA and DHA reduced severe ROP compared with the standard of care (16 of 101 [15.8%] in the AA:DHA group vs 35 of 105 [33.3%] in the control group; adjusted relative risk, 0.50 [95% CI, 0.28-0.91]; P =.02). The AA:DHA group had significantly higher fractions of AA and DHA in serum phospholipids compared with controls (overall mean difference in AA:DHA group, 0.82 mol% [95% CI, 0.46-1.18 mol%]; P <.001; overall mean difference in control group, 0.13 mol% [95% CI, 0.01-0.24 mol%]; P =.03). There were no significant differences between the AA:DHA group and the control group in the rates of bronchopulmonary dysplasia (48 of 101 [47.5%] vs 48 of 105 [45.7%]) and of any grade of intraventricular hemorrhage (43 of 101 [42.6%] vs 42 of 105 [40.0%]). In the AA:DHA group and control group, respectively, sepsis occurred in 42 of 101 infants (41.6%) and 53 of 105 infants (50.5%), serious adverse events occurred in 26 of 101 infants (25.7%) and 26 of 105 infants (24.8%), and 16 of 101 infants (15.8%) and 13 of 106 infants (12.3%) died. CONCLUSIONS AND RELEVANCE This study found that, compared with standard of care, enteral AA:DHA supplementation lowered the risk of severe ROP by 50% and showed overall higher serum levels of both AA and DHA. Enteral lipid supplementation with AA:DHA is a novel preventive strategy to decrease severe ROP in extremely preterm infants.
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| 22. |
- Hård, Anna Lena, et al.
(author)
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Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk
- 2019
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In: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253 .- 1651-2227. ; 108:6, s. 998-1007
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Journal article (peer-reviewed)abstract
- Aim: This nonsystematic review examined differences in the composition of raw maternal breastmilk and pasteurised donor milk and possible health effects on preterm infants. Methods: We searched PubMed up to July 2018 for studies published in English that focused on four comparisons as follows: raw maternal milk versus donor milk, human milk before and after Holder pasteurisation, milk from mothers who delivered preterm and at term and milk collected during early and late lactation. We also searched for possible effects of the milk components, as well as the effects of maternal and donor milk on preterm infants’ health. Results: Raw maternal milk contained factors involved in antioxidant and anti-inflammatory defence, gut microbiome establishment and the maturation of immune defences, food tolerability and metabolism. Many of these factors were reduced or abolished in processed donor milk. Both maternal milk and donor milk have been associated with a reduced incidence of necrotising enterocolitis. High-dose feeding with maternal milk during the neonatal period reportedly reduced the risk of other morbidities and promoted growth and neurodevelopment. Conclusion: Many of the components in raw maternal breastmilk were lacking in pasteurised donor milk, which was inferior in promoting the growth and development of very preterm infants.
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| 23. |
- Lund, Anna, et al.
(author)
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Beskärningsårstider : Omdiskuterat ämne med skral forskningsbakgrund
- 2023
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In: Movium Fakta. - 2001-2357.
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Other publication (pop. science, debate, etc.)abstract
- Beskärning är en nödvändighet i många urbana miljöer, men vad vet vi egentligen om vilken tidpunkt som är bäst för att beskära olika arter? I det här faktabladet sammanfattar vi forskningsläget, presenterar en ny studie och diskuterar vad resultaten av den innebär i praktiken.
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| 24. |
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| 25. |
- Lund, Anna My, et al.
(author)
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Unpasteurised maternal breast milk is positively associated with growth outcomes in extremely preterm infants
- 2020
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In: Acta Paediatrica. - Oxford, UK : Wiley. - 0803-5253 .- 1651-2227. ; 109:6
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Journal article (peer-reviewed)abstract
- Aim Extrauterine growth restriction is common among extremely preterm infants. We explored whether intake of unpasteurised maternal milk (MM) and pasteurised donor milk (DM) was associated with longitudinal growth outcomes and neonatal morbidities in extremely preterm infants. Methods Observational study of 90 preterm infants born between 2013 and 2015 in Gothenburg, Sweden. Data were prospectively collected on nutritional and breast milk intakes during the first 28 days. Results Ninety infants (39 girls and 51 boys) with a median gestational age of 25.3 (22.7-27.9) weeks were evaluated. MM intake (mL/kg/d) correlated positively with almost all z-scores for weight, length and head circumference at 28 postnatal days and at postmenstrual age (PMA) 32 and 36 weeks. After multivariable adjustment, MM intake and weight z-score at 28 postnatal days and at PMA 32 and 36 weeks remained significantly associated. Infants consuming >= 80% MM had more favourable weight z-scores at PMA 32 and 36 weeks. Intake of DM did not correlate with any growth outcomes. Infants without retinopathy of prematurity had a significantly higher intake of MM (mL/kg/d). Conclusion Unpasteurised MM was positively associated with longitudinal growth outcomes. Motivating mothers to provide their infants with their own milk after preterm birth should be emphasised.
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| 26. |
- Lund, Anna, 1969-, et al.
(author)
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Skolframgång och mångkulturell inkorporering
- 2016
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In: Skolframgång i det mångkulturella samhället. - Lund : Studentlitteratur AB. - 9789144093529 ; , s. 13-35
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Book chapter (other academic/artistic)
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| 27. |
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| 28. |
- Ostergaard, Mikkel, et al.
(author)
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Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis : 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
- 2023
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In: Annals of the Rheumatic Diseases. - : BMJ PUBLISHING GROUP. - 0003-4967 .- 1468-2060. ; 82:10, s. 1286-1295
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Journal article (peer-reviewed)abstract
- Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naive early RA with moderate-severe disease activity were randomised 1:1:1:1 to methotrexate combined with (1) active conventional therapy: oral prednisolone (tapered quickly, discontinued at week 36) or sulfasalazine, hydroxychloroquine and intra-articular glucocorticoid injections in swollen joints; (2) certolizumab pegol; (3) abatacept or (4) tocilizumab. Coprimary endpoints were week 48 Clinical Disease Activity Index (CDAI) remission (CDAI <= 2.8) and change in radiographic van der Heijde-modified Sharp Score, estimated using logistic regression and analysis of covariance, adjusted for sex, anticitrullinated protein antibody status and country. Bonferroni's and Dunnet's procedures adjusted for multiple testing (significance level: 0.025). Results Eight hundred and twelve patients were randomised. Adjusted CDAI remission rates at week 48 were: 59.3% (abatacept), 52.3% (certolizumab), 51.9% (tocilizumab) and 39.2% (active conventional therapy). Compared with active conventional therapy, CDAI remission rates were significantly higher for abatacept (adjusted difference +20.1%, p<0.001) and certolizumab (+13.1%, p=0.021), but not for tocilizumab (+12.7%, p=0.030). Key secondary clinical outcomes were consistently better in biological groups. Radiographic progression was low, without group differences. Conclusions Compared with active conventional therapy, clinical remission rates were superior for abatacept and certolizumab pegol, but not for tocilizumab. Radiographic progression was low and similar between treatments.
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| 29. |
- Schrage, Benedikt, et al.
(author)
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Lower socioeconomic status predicts higher mortality and morbidity in patients with heart failure
- 2021
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In: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 107:3, s. 229-236
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Journal article (peer-reviewed)abstract
- Objective It is not fully understood whether and how socioeconomic status (SES) has a prognostic impact in patients with heart failure (HF). We assessed SES and its association with patient characteristics and outcomes in a contemporary and well-characterised HF cohort. Methods Socioeconomic risk factors (SERF) were defined in the Swedish HF Registry based on income (low vs high according to the annual median value), education level (no degree/compulsory school vs university/secondary school) and living arrangement (living alone vs cohabitating). Results Of 44 631 patients, 21% had no, 33% one, 30% two and 16% three SERF. Patient characteristics strongly and independently associated with lower SES were female sex and no specialist referral. Additional independent associations were older age, more severe HF, heavier comorbidity burden, use of diuretics and less use of HF devices. Lower SES was associated with higher risk of HF hospitalisation/mortality, and overall cardiovascular and non-cardiovascular events. These associations persisted after extensive adjustment for patient characteristics, treatments and care. The magnitude of the association increased linearly with the increasing number of coexistent SERF: HR (95% CI) 1.09 (1.05 to 1.13) for one, 1.16 (1.12 to 1.20) for two and 1.22 (1.18 to 1.28) for three SERF (p<0.01). Conclusions In a contemporary and well-characterised HF cohort and after comprehensive adjustment for confounders, lower SES was linked with multiple factors such as less use of HF devices and age, but most strongly with female sex and lack of specialist referral; and associated with greater risk of morbidity/mortality.
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| 30. |
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Skolframgång i det mångkulturella samhället
- 2016
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Editorial collection (other academic/artistic)abstract
- Skollagen och majoriteten av den svenska befolkningen är eniga. Unga människor ska oberoende av kön, social bakgrund och etnicitet kunna ha samma framtidsmöjligheter. Samtidigt visar utbildningsvetenskaplig forskning på generellt försämrade skolprestationer, ökad skolsegregation och stora skillnader i genomsnittliga betygsnivåer mellan skolor.I glappet mellan skolans uppdrag och dess verklighet visar denna bok vägen framåt. På vetenskaplig grund ger kapitlen svar på frågan: Vilka är framgångsfaktorerna i mångkulturella skolor?Avgörande är inte bara en skolkultur där elever kan vara olika utan även, som Mats Trondman skriver i bokens sammanfattande analys: att eleverna kan lära sig så att de lär sig att de kan lära sig.Boken vänder sig till blivande och verksamma lärare, skolledare och elevvårdspersonal med intresse för skola och utbildning i ett mångkulturellt samhälle.
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| 31. |
- Trondman, Mats, et al.
(author)
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Socio-symbolic homologies : Exploring Paul Willis’ theory of cultural forms
- 2011
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In: European Journal of Cultural Studies. - : Sage. - 1367-5494 .- 1460-3551. ; 14:5, s. 573-592
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Journal article (peer-reviewed)abstract
- Thirty years have passed since Paul Willis formulated a theory of cultural forms in the appendix to his seminal work Profane Culture. In this article we are driven by the conviction that Willis’ theory is a forgotten treasure trove that needs to be recovered, challenged and developed. The argument is guided by three aims. First, we provide a construction of the theory’s main content. Second, we search for possibilities of enlarging the content and scope of his theory. Third, we reconstruct one of the basic underlying arguments of Willis’ theory, that cultural items in themselves carry a given meaning in relation to social groups. In so doing we partly reconstruct Willis’ understanding of ‘objective’ possibilities as something essentially given in time and space. We utilize the example of the car make Cadillac to demonstrate that cultural items also attract because they are already occupied by socioculturally constructed systems of meaning.
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| 32. |
- Uhlén, Mathias, et al.
(author)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Journal article (peer-reviewed)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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| 33. |
- Aad, G., et al.
(author)
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- 2015
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In: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 92:3
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Journal article (peer-reviewed)
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| 34. |
- Aad, G., et al.
(author)
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- 2015
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
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Journal article (peer-reviewed)
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| 35. |
- Aad, G., et al.
(author)
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- 2015
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Journal article (peer-reviewed)
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| 36. |
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| 37. |
- Abulaiti, Yiming, et al.
(author)
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A measurement of material in the ATLAS tracker using secondary hadronic interactions in 7 TeV p p collisions
- 2016
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In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 11
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Journal article (peer-reviewed)abstract
- Knowledge of the material in the ATLAS inner tracking detector is crucial in under-standing the reconstruction of charged-particle tracks, the performance of algorithms that identify jets containing b-hadrons and is also essential to reduce background in searches for exotic particles that can decay within the inner detector volume. Interactions of primary hadrons produced in pp collisions with the material in the inner detector are used to map the location and amount of this material. The hadronic interactions of primary particles may result in secondary vertices, which in this analysis are reconstructed by an inclusive vertex-finding algorithm. Data were collected using minimum-bias triggers by the ATLAS detector operating at the LHC during 2010 at centre-of-mass energy root s = 7 TeV, and correspond to an integrated luminosity of 19 nb(-1). Kinematic properties of these secondary vertices are used to study the validity of the modelling of hadronic interactions in simulation. Secondary-vertex yields are compared between data and simulation over a volume of about 0.7m(3) around the interaction point, and agreement is found within overall uncertainties.
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| 38. |
- Abulaiti, Yiming, et al.
(author)
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A measurement of the calorimeter response to single hadrons and determination of the jet energy scale uncertainty using LHC Run-1 pp-collision data with the ATLAS detector
- 2017
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:1
-
Journal article (peer-reviewed)abstract
- A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb(-1) of proton-proton collision data at root s = 7 TeV from 2010 and 0.1 nb(-1) of data at root s = 8 TeV from 2012. A number of aspects of the calorimeter response to isolated hadrons are explored. After accounting for energy deposited by neutral particles, there is a 5% discrepancy in the modelling, using various sets of GEANT4 hadronic physics models, of the calorimeter response to isolated charged hadrons in the central calorimeter region. The description of the response to anti-protons at low momenta is found to be improved with respect to previous analyses. The electromagnetic and hadronic calorimeters are also examined separately, and the detector simulation is found to describe the response in the hadronic calorimeter well. The jet energy scale uncertainty and correlations in scale between jets of different momenta and pseudorapidity are derived based on these studies. The uncertainty is 2-5% for jets with transverse momenta above 2 TeV, where this method provides the jet energy scale uncertainty for ATLAS.
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| 39. |
- Abulaiti, Yiming, et al.
(author)
-
A search for pair-produced resonances in four-jet final states at root s=13 TeV with the ATLAS detector
- 2018
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:3
-
Journal article (peer-reviewed)abstract
- A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb(-1) of root s = 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the background prediction is observed. Results are interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, (t) over tilde, which decays promptly into two quarks through R-parity-violating couplings. Top squarks with masses in the range 100 GeV < m((T) over tilde) < 410 GeV are excluded at 95% confidence level. If the decay is into a b-quark and a light quark, a dedicated selection requiring two b-tags is used to exclude masses in the ranges 100 GeV < m((t) over tilde) < 470 GeV and 480 GeV < m(<(t)over tilde>) < 610 GeV. Additional limits are set on the pair-production of massive colour-octet resonances.
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| 40. |
- Abulaiti, Yiming, et al.
(author)
-
A search for resonances decaying into a Higgs boson and a new particle X in the XH -> qqbb final state with the ATLAS detector
- 2018
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 779, s. 24-45
-
Journal article (peer-reviewed)abstract
- A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb(-1) of proton-proton collision data at root s = 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle Xis assumed to decay to a pair of light quarks, and the fully hadronic final state XH -> q (q) over bar 'b (b) over bar is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the XH -> q (q) over bar 'b (b) over bar resonance.
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| 41. |
- Abulaiti, Yiming, et al.
(author)
-
A search for top squarks with R-parity-violating decays to all-hadronic final states with the ATLAS detector in root s=8 TeV proton-proton collisions
- 2016
-
In: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :6
-
Journal article (peer-reviewed)abstract
- A search for the pair production of top squarks, each with R-parity-violating decays into two Standard Model quarks, is performed using 17.4 fb(-1) of root s = 8 TeV proton-proton collision data recorded by the ATLAS experiment at the LITC. Each top squark is assumed to decay to a b- and an 8-quark, leading to four quarks in the final state. Background discrimination is achieved with the use of b-tagging and selections on the mass and substructure of large-radius jets, providing sensitivity to top squark masses as low as 100 GeV. No evidence of an excess beyond the Standard Model background prediction is observed and top squalls decaying to bs are excluded for top squark masses in the range 100 <= m((t) over tilde) <= 315 GeV at 95% confidence level.
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| 42. |
- Abulaiti, Yiming, et al.
(author)
-
Analysis of events with b-jets and a pair of leptons of the same charge in pp collisions at root s=8 TeV with the ATLAS detector
- 2015
-
In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :10
-
Journal article (peer-reviewed)abstract
- An analysis is presented of events containing jets including at least one b-tagged jet, sizeable missing transverse momentum, and at least two leptons including a pair of the same electric charge, with the scalar sum of the jet and lepton transverse momenta being large. A data sample with an integrated luminosity of 20.3 fb(-1) of pp collisions at root s = 8 TeV recorded by the ATLAS detector at the Large Hadron Collider is used. Standard Model processes rarely produce these final states, but there are several models of physics beyond the Standard Model that predict an enhanced rate of production of such events; the ones considered here are production of vector-like quarks, enhanced fourtop-quark production, pair production of chiral b '-quarks, and production of two positively charged top quarks. Eleven signal regions are defined; subsets of these regions are combined when searching for each class of models. In the three signal regions primarily sensitive to positively charged top quark pair production, the data yield is consistent with the background expectation. There are more data events than expected from background in the set of eight signal regions defined for searching for vector-like quarks and chiral b ' quarks, but the significance of the discrepancy is less than two standard deviations. The discrepancy reaches 2.5 standard deviations in the set of five signal regions defined for searching for four-top-quark production. The results are used to set 95% CL limits on various models.
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| 43. |
- Abulaiti, Yiming, et al.
(author)
-
Analysis of the Wtb vertex from the measurement of triple-differential angular decay rates of single top quarks produced in the t-channel at root s=8 TeV with the ATLAS detector
- 2017
-
In: Journal of High Energy Physics (JHEP). - : Springer Berlin/Heidelberg. - 1126-6708 .- 1029-8479. ; :12
-
Journal article (peer-reviewed)abstract
- The electroweak production and subsequent decay of single top quarks in the t-channel is determined by the properties of the Wtb vertex, which can be described by the complex parameters of an effective Lagrangian. An analysis of a triple-differential decay rate in t-channel production is used to simultaneously determine five generalised helicity fractions and phases, as well as the polarisation of the produced top quark. The complex parameters are then constrained. This analysis is based on 20.2 fb(-1) of proton-proton collision data at a centre-of-mass energy of 8 TeV collected with the ATLAS detector at the LHC. The fraction of decays containing transversely polarised W bosons is measured to be f(1) = 0.30 +/- 0.05. The phase between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be delta = 0.002 pi(+0.016 pi)(+0.017 pi), giving no indication of CP violation. The fractions of longitudinal or transverse W bosons accompanied by right-handed b-quarks are also constrained. Based on these measurements, limits are placed at 95% CL on the ratio of the complex coupling parameters Re [g(R)/V-L is an element of [-0.12, 0.17] and Im [g(R)/V-L is an element of [-0.07, 0.06]. Constraints are also placed on the ratios vertical bar V-R/V-L vertical bar and vertical bar g(L)/V-L vertical bar. In addition, the polarisation of single top quarks in the t-channel is constrained to be P > 0.72 (95% CL). None of the above measurements make assumptions about the value of any of the other parameters or couplings and all of them are in agreement with the Standard Model.
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| 44. |
- Abulaiti, Yiming, et al.
(author)
-
Angular analysis of B-d(0) -> K* mu(+)mu(-) decays in pp collisions at root s=8 TeV with the ATLAS detector
- 2018
-
In: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :10
-
Journal article (peer-reviewed)abstract
- An angular analysis of the decay B-d(0) -> K*mu(+)mu(-) is presented, based on proton-proton collision data recorded by the ATLAS experiment at the LHC. The study is using 20.3 fb(-1) of integrated luminosity collected during 2012 at centre-of-mass energy of root s = 8TeV. Measurements of the K* longitudinal polarisation fraction and a set of angular parameters obtained for this decay are presented. The results are compatible with the Standard Model predictions.
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| 45. |
- Abulaiti, Yiming, et al.
(author)
-
Charged-particle distributions at low transverse momentum in root s=13 TeV pp interactions measured with the ATLAS detector at the LHC
- 2016
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:9
-
Journal article (peer-reviewed)abstract
- Measurements of distributions of charged particles produced in proton-proton collisions with a centre-of-mass energy of 13 TeV are presented. The data were recorded by the ATLAS detector at the LHC and correspond to an integrated luminosity of 151 mu b(-1). The particles are required to have a transverse momentum greater than 100 MeV and an absolute pseudorapidity less than 2.5. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence of the mean transverse momentum on multiplicity are measured in events containing at least two charged particles satisfying the above kinematic criteria. The results are corrected for detector effects and compared to the predictions from several Monte Carlo event generators.
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| 46. |
- Abulaiti, Yiming, et al.
(author)
-
Charged-particle distributions in pp interactions at root s=8TeV measured with the ATLAS detector
- 2016
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:7
-
Journal article (peer-reviewed)abstract
- This paper presents measurements of distributions of charged particles which are produced in proton-proton collisions at a centre-of-mass energy of root s = 8TeV and recorded by the ATLAS detector at the LHC. A special dataset recorded in 2012 with a small number of interactions per beam crossing (below 0.004) and corresponding to an integrated luminosity of 160 mu b(-1) was used. A minimumbias trigger was utilised to select a data sample of more than 9 million collision events. The multiplicity, pseudorapidity, and transverse momentum distributions of charged particles are shown in different regions of kinematics and charged-particle multiplicity, including measurements of final states at high multiplicity. The results are corrected for detector effects and are compared to the predictions of various Monte Carlo event generator models which simulate the full hadronic final state.
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| 47. |
- Abulaiti, Yiming, et al.
(author)
-
Charged-particle distributions in root s=13 TeV pp interactions measured with the ATLAS detector at the LHC
- 2016
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 758, s. 67-88
-
Journal article (peer-reviewed)abstract
- Charged-particle distributions are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV, using a data sample of nearly 9 million events, corresponding to an integrated luminosity of 170 mu b(-1), recorded by the ATLAS detector during a special Large Hadron Collider fill. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence of the mean transverse momentum on the charged-particle multiplicity are presented. The measurements are performed with charged particles with transverse momentum greater than 500 MeV and absolute pseudorapidity less than 2.5, in events with at least one charged particle satisfying these kinematic requirements. Additional measurements in a reduced phase space with absolute pseudorapidity less than 0.8 are also presented, in order to compare with other experiments. The results are corrected for detector effects, presented as particle-level distributions and are compared to the predictions of various Monte Carlo event generators.
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| 48. |
- Abulaiti, Yiming, et al.
(author)
-
Combination of inclusive and differential t(t)over-bar charge asymmetry measurements using ATLAS and CMS data at root S =7 and 8 TeV
- 2018
-
In: Journal of High Energy Physics (JHEP). - : Springer-Verlag New York. - 1126-6708 .- 1029-8479. ; :4
-
Journal article (peer-reviewed)abstract
- This paper presents combinations of inclusive and differential measurements of the charge asymmetry (A(C)) in top quark pair (t(t)over-bar) events with a lepton+jets signature by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at centre-of-mass energies of 7 and 8 TeV. The data correspond to integrated luminosities of about 5 and 20 fb(-1) for each experiment, respectively. The resulting combined LHC measurements of the inclusive charge asymmetry are A(C)(LHC7) = 0.005 +/- 0.007 (stat) +/- 0.006 (syst) at 7 TeV and A(C)(LHC8) = 0.0055 +/- 0.0023 (stat) +/- 0.0025 (syst) at 8 TeV. These values, as well as the combination of A(C )measurements as a function of the invariant mass of the t(t)over-bar system at 8 TeV, are consistent with the respective standard model predictions.
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| 49. |
- Abulaiti, Yiming, et al.
(author)
-
Combination of searches for WW, WZ, and ZZ resonances in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 755, s. 285-305
-
Journal article (peer-reviewed)abstract
- The ATLAS experiment at the CERN Large Hadron Collider has performed searches for new, heavy bosons decaying to WW, WZ and ZZ final states in multiple decay channels using 20.3 fb(-1) of pp collision data at root s = 8 TeV. In the current study, the results of these searches are combined to provide a more stringent test of models predicting heavy resonances with couplings to vector bosons. Direct searches for a charged diboson resonance decaying to WZ in the l nu l'l' (l = mu, e), llq (q) over bar, l nu q (q) over bar and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WZ bosons are compared with predictions of an extended gauge model with a heavy W' boson. In addition, direct searches for a neutral diboson resonance decaying to WW and ZZ in the llq (q) over bar, l nu q (q) over bar, and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WW and ZZ bosons are compared with predictions for a heavy, spin-2 graviton in an extended Randall-Sundrum model where the Standard Model fields are allowed to propagate in the bulk of the extra dimension.
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| 50. |
- Abulaiti, Yiming, et al.
(author)
-
Dark matter interpretations of ATLAS searches for the electroweak production of supersymmetric particles in root s=8 TeV proton-proton collisions
- 2016
-
In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :9
-
Journal article (peer-reviewed)abstract
- A selection of searches by the ATLAS experiment at the LHC for the electroweak production of SUSY particles are used to study their impact on the constraints on dark matter candidates. The searches use 20 fb(-1) of proton-proton collision data at root s = 8 TeV. A likelihood-driven scan of a five-dimensional effective model focusing on the gaugino-higgsino and Higgs sector of the phenomenological minimal supersymmetric Standard Model is performed. This scan uses data from direct dark matter detection experiments, the relic dark matter density and precision flavour physics results. Further constraints from the ATLAS Higgs mass measurement and SUSY searches at LEP are also applied. A subset of models selected from this scan are used to assess the impact of the selected ATLAS searches in this five-dimensional parameter space. These ATLAS searches substantially impact those models for which the mass m((chi) over tilde (0)(1)) of the lightest neutralino is less than 65 GeV, excluding 86% of such models. The searches have limited impact on models with larger m((chi) over tilde (0)(1)) due to either heavy electroweakinos or compressed mass spectra where the mass splittings between the produced particles and the lightest supersymmetric particle is small.
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