| 1. |
- Barbateskovic, Marija, et al.
(författare)
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A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions
- 2021
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Ingår i: Journal of Clinical Epidemiology. - : Elsevier BV. - 0895-4356 .- 1878-5921. ; 135, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions. Study design and setting: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups. Results: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age, sex, patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention, timing, control intervention, cointerventions); and outcome (definition of outcome, timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters. Conclusion: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.
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| 2. |
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| 3. |
- Rydén, Patrik, 1969-, et al.
(författare)
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Outbreaks of tularemia in a boreal forest region depends on mosquito prevalence
- 2012
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 205:2, s. 297-304
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Tidskriftsartikel (refereegranskat)abstract
- Background. We aimed to evaluate the potential association of mosquito prevalence in a boreal forest area with transmission of the bacterial disease tularemia to humans, and model the annual variation of disease using local weather data.Methods. A prediction model for mosquito abundance was built using weather and mosquito catch data. Then a negative binomial regression model based on the predicted mosquito abundance and local weather data was built to predict annual numbers of humans contracting tularemia in Dalarna County, Sweden.Results. Three hundred seventy humans were diagnosed with tularemia between 1981 and 2007, 94% of them during 7 summer outbreaks. Disease transmission was concentrated along rivers in the area. The predicted mosquito abundance was correlated (0.41, P < .05) with the annual number of human cases. The predicted mosquito peaks consistently preceded the median onset time of human tularemia (temporal correlation, 0.76; P < .05). Our final predictive model included 5 environmental variables and identified 6 of the 7 outbreaks.Conclusions. This work suggests that a high prevalence of mosquitoes in late summer is a prerequisite for outbreaks of tularemia in a tularemia-endemic boreal forest area of Sweden and that environmental variables can be used as risk indicators.
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| 4. |
- Scandurra, Isabella, 1973-, et al.
(författare)
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Advancing the State-of-the-Art for Virtual Autopsies : Initial Forensic Workflow Study
- 2010
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Ingår i: Studies in Health Technology and Informatics. - : IOS Press. - 0926-9630 .- 1879-8365. ; 160, s. 639-643
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Tidskriftsartikel (refereegranskat)abstract
- There are numerous advantages described of how imaging technology can support forensic examinations. However, postmortem examinations of bodies are mainly performed to address demands which differ from those of traditional clinical image processing. This needs to be kept in mind when gathering information from image data sets for forensic purposes. To support radiologists and forensicclinicians using Virtual Autopsy technologies, an initial workflow study regarding post-mortem imaging has been performed, aiming to receive an improved understanding of how Virtual Autopsyworkstations, image data sets and processes can be adjusted to support and improve conventional autopsies. This paper presents potential impacts and a current forensic Virtual Autopsy workflowaiming to form a foundation for collaborative procedures that increase the value of Virtual Autopsy. The workflow study will provide an increased and mutual understanding of involved professionals. In addition, insight into future forensic workflows based on demands from both forensic and radiologist perspectives bring visualization and medical informatics researchers together to develop and improvethe technology and software needed.
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| 5. |
- Ambrosi, Aurelie, et al.
(författare)
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Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
- 2012
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Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 71:3, s. 334-340
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Tidskriftsartikel (refereegranskat)abstract
- Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. less thanbrgreater than less thanbrgreater thanMethods The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. less thanbrgreater than less thanbrgreater thanResults There was a recurrence rate of 12.1% in Ro/La-positive women, and no recurrence in Ro/La-negative women. Fetal gender and parity did not influence the development of heart block in either group. Maternal age in Ro/La-positive pregnancies with a child affected by heart block was, however, significantly higher than in pregnancies resulting in babies without heart block (pandlt;0.05). Seasonal timing of pregnancy influenced the outcome. Gestational susceptibility weeks 18-24 occurring during January-March correlated with a higher proportion of children with heart block and lower vitamin D levels during the same period in a representative sample of Swedish women and a corresponding higher proportion of children with heart block born in the summer (pandlt;0.02). Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. less thanbrgreater than less thanbrgreater thanConclusion This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. These observations may be useful for counselling when pregnancy is considered.
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| 6. |
- Andersson, Anders G., et al.
(författare)
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Simulation of free surface flow in a spillway with the rigid lid and volume of fluid methods and validation in a scale model
- 2010
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Ingår i: Proceedings, Fifth European Conference on Computational Fluid Dynamics. - 9789899677814
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Konferensbidrag (refereegranskat)abstract
- Simulations on the spilling from a dam were performed and compared to experimental results from a physical scale model. Both mechanical and acoustic methods to measure the velocity were used. The model has three gates leading into the spillway that can be maneuvered separately. At first two of the gates were closed and the inlet flow was high enough to get a fully wetted outlet at the third gate. This case was simulated with a rigid lid approximation since the water surface was considered to be plane. The water surface level was taken from the scale model. In the second case, all three gates were open resulting in a free water surface through all the gates to the spillway. This case was simulated with the Volume of Fluids method were both water and air phase were considered. Water levels, velocities and the shape of the water surface were compared between simulations and experiments. The simulations capture both qualitative features such as a vortex near the outlet and show good quantitative agreement with the experiments.
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| 7. |
- Bach, Anders, et al.
(författare)
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A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
- 2012
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:9, s. 3317-3322
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Tidskriftsartikel (refereegranskat)abstract
- Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-D-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are lacking. Here we report the design and synthesis of a novel dimeric inhibitor, Tat-NPEG4(IETDV)(2) (Tat-N-dimer), which binds the tandem PDZ1-2 domain of PSD-95 with an unprecedented high affinity of 4.6 nM, and displays extensive protease-resistance as evaluated in vitro by stability-measurements in human blood plasma. X-ray crystallography, NMR, and small-angle X-ray scattering (SAXS) deduced a true bivalent interaction between dimeric inhibitor and PDZ1-2, and also provided a dynamic model of the conformational changes of PDZ1-2 induced by the dimeric inhibitor. A single intravenous injection of Tat-N-dimer (3 nmol/g) to mice subjected to focal cerebral ischemia reduces infarct volume with 40% and restores motor functions. Thus, Tat-N-dimer is a highly efficacious neuroprotective agent with therapeutic potential in stroke.
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| 8. |
- Berglund, Karin, 1967-
(författare)
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Jakten på Entreprenörer : Om öppningar och låsningar i entreprenörskapsdiskursen
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Entrepreneurs are expected to play a crucial role in times of unemployment and economical regression. A “hunt for entrepreneurs” can thus be said to be occurring as they appear to be people who can save nations, societies, and companies in troublesome situations. The project Diversity in Entrepreneurship (DiE) aimed to introduce a broad view of entrepreneurship in a regional context. Three development areas are emphasized that are strategically important to transforming a traditional industrial community into an entrepreneurial region: paying attention to the spirit of enterprise among underrepresented groups; stimulating entrepreneurship among young people; and considering the importance of culture in stimulating a diverse and entrepreneurial society.An equality discourse is introduced through DiE that – emphasising social and mundane occurrences - stands in contrast to the historically rooted enterprise discourse that proffers companies as productive apparatus, where a few competent people – often men – have been, and still are, in charge. In the equality discourse, all people in the region make a difference, not merely a few. The encounter of the two discourses has resulted in confusion, and thus conflicts and collisions; but also in new possibilities.A new perspective of entrepreneurship and regional development is developed where conflicts are put forward as constructive. That the two discourses met on the same regional scene is therefore seen as positive as many people have been made aware of the social, political, and economic contradictions which restrain some groups in society from creating a (working) life. Hence, the contradictions have enabled the inhabitants to see themselves, and others, as entrepreneurs in regional development processes. Openings have thus emerged to view entrepreneurship from a broader perspective that includes people, to create practices through which a more diverse working life is becoming discernible.
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| 9. |
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| 10. |
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| 11. |
- Hägg, Sara, et al.
(författare)
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Molecular Phenotypes of Coronary Artery Disease : The Stockholm Atherosclerosis Gene Expression (STAGE) Study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- BACKGROUNDBy offering a comprehensive view of the molecular underpinnings of pathology, high-dimensional data have the potential to revolutionize the diagnosis and management of complex disorders such as coronary artery disease (CAD). To identify molecular phenotypes of CAD, we performed multi organ gene expression profiling of subjects enrolled in the Stockholm Atherosclerosis Gene Expression (STAGE) study.METHODSAtherosclerotic and unaffected arterial wall, liver, skeletal muscle, and mediastinal fat biopsies were obtained during coronary artery bypass grafting from 114 well-characterized CAD patients. RNA samples were isolated, and 278 transcription profiles were obtained using Affymetrix HG-U133_Plus_2 GeneChips.RESULTSThe most prominent molecular phenotype of the CAD patients was represented by 733 genes in mediastinal fat, which were involved in extracellular matrix organization, response to stress and regulation of programmed cell death. Other aspects of this phenotype were shared with liver (e.g., oxidoreductase activity), skeletal muscle (insulin-like growth factor binding), and atherosclerotic arterial wall (cell motility and adhesion, fatty acid metabolism). In addition, the activity of 400 genes exclusively in mediastinal fat was associated with the extent of coronary stenosis and atherosclerosis. Immune-cell activation in mediastinal fat defined CAD patients with poor blood glucose control and prolonged hospitalization.CONCLUSIONSThe molecular phenotype of mediastinal fat appears to be central in CAD and should be useful for early identification of CAD risk.
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| 12. |
- Hägg, Sara, 1977-, et al.
(författare)
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Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2 : The Stockholm Atherosclerosis Gene Expression (STAGE) Study
- 2009
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Ingår i: PLoS Genetics. - : PLoS Genetics. - 1553-7390 .- 1553-7404. ; 5:12, s. e1000754-
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Tidskriftsartikel (refereegranskat)abstract
- Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coronary artery disease (CAD). The primary aim of the Stockholm Atherosclerosis Gene Expression (STAGE) study was to determine whether there are functionally associated genes (rather than individual genes) important for CAD development. To this end, two-way clustering was used on 278 transcriptional profiles of liver, skeletal muscle, and visceral fat (n=66/tissue) and atherosclerotic and unaffected arterial wall (n=40/tissue) isolated from CAD patients during coronary artery bypass surgery. The first step, across all mRNA signals (n=15,042/12,621 RefSeqs/genes) in each tissue, resulted in a total of 60 tissue clusters (n=3958 genes). In the second step (performed within tissue clusters), one atherosclerotic lesion (n=49/48) and one visceral fat (n=59) cluster segregated the patients into two groups that differed in the extent of coronary stenosis (P=0.008 and P=0.00015). The associations of these clusters with coronary atherosclerosis were validated by analyzing carotid atherosclerosis expression profiles. Remarkably, in one cluster (n=55/54) relating to carotid stenosis (P=0.04), 27 genes in the two clusters relating to coronary stenosis were confirmed (n=16/17, P<10-27and-30). Genes in the transendothelial migration of leukocytes (TEML) pathway were overrepresented in all three clusters, referred to as the atherosclerosis module (A-module). In a second validation step, using three independent cohorts, the A-module was found to be genetically enriched with CAD risk by 1.8-fold (P<0.004). The transcription co-factor LIM domain binding 2 (LDB2) was identified as a potential high-hierarchy regulator of the A-module, a notion supported by subnetwork analysis, cellular and lesion expression of LDB2, and the expression of 13 TEML genes in Ldb2-deficient arterial wall. Thus, the A-module appears to be important for atherosclerosis development and together with LDB2 merits further attention in CAD research.
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| 13. |
- Lindholm, Stefan, et al.
(författare)
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Spatial Conditioning of Transfer Functions Using Local Material Distributions
- 2010
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Ingår i: IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS. - : IEEE. - 1077-2626. ; 16:6, s. 1301-1310
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Tidskriftsartikel (refereegranskat)abstract
- In many applications of Direct Volume Rendering (DVR) the importance of a certain material or feature is highly dependent on its relative spatial location. For instance, in the medical diagnostic procedure, the patients symptoms often lead to specification of features, tissues and organs of particular interest. One such example is pockets of gas which, if found inside the body at abnormal locations, are a crucial part of a diagnostic visualization. This paper presents an approach that enhances DVR transfer function design with spatial localization based on user specified material dependencies. Semantic expressions are used to define conditions based on relations between different materials, such as only render iodine uptake when close to liver. The underlying methods rely on estimations of material distributions which are acquired by weighing local neighborhoods of the data against approximations of material likelihood functions. This information is encoded and used to influence rendering according to the users specifications. The result is improved focus on important features by allowing the user to suppress spatially less-important data. In line with requirements from actual clinical DVR practice, the methods do not require explicit material segmentation that would be impossible or prohibitively time-consuming to achieve in most real cases. The scheme scales well to higher dimensions which accounts for multi-dimensional transfer functions and multivariate data. Dual-Energy Computed Tomography, an important new modality in radiology, is used to demonstrate this scalability. In several examples we show significantly improved focus on clinically important aspects in the rendered images.
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| 14. |
- Ljung, Patric, 1968-, et al.
(författare)
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Forensic Virtual Autopsies by Direct Volume Rendering
- 2007
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Ingår i: IEEE signal processing magazine (Print). - Piscataway, NJ, USA : IEEE. - 1053-5888 .- 1558-0792. ; 24:6, s. 112-116
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents state-of-the-art methods, which address the technical challenges in visualizing large three-dimensional (3D) data and enable rendering at interactive frame rates.
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| 15. |
- Ljung, Patric, 1968-, et al.
(författare)
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Full Body Virtual Autopsies Using A State-of-the-art Volume Rendering Pipeline
- 2006
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Ingår i: IEEE Transactions on Visualization and Computer Graphics. - 1077-2626 .- 1941-0506. ; 12:5, s. 869-876
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents a procedure for virtual autopsies based on interactive 3D visualizations of large scale, high resolutiondata from CT-scans of human cadavers. The procedure is described using examples from forensic medicine and the added valueand future potential of virtual autopsies is shown from a medical and forensic perspective. Based on the technical demands ofthe procedure state-of-the-art volume rendering techniques are applied and refined to enable real-time, full body virtual autopsiesinvolving gigabyte sized data on standard GPUs. The techniques applied include transfer function based data reduction using levelof-detail selection and multi-resolution rendering techniques. The paper also describes a data management component for large,out-of-core data sets and an extension to the GPU-based raycaster for efficient dual TF rendering. Detailed benchmarks of thepipeline are presented using data sets from forensic cases.
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| 16. |
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| 17. |
- Lundström, Anton, et al.
(författare)
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Enough power to move : Dimensions for representing energy availability
- 2012
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Ingår i: MobileHCI'12 - Proceedings of the 14th International Conference on Human Computer Interaction with Mobile Devices and Services. - New York, NY, USA : ACM. - 9781450311052 ; , s. 201-210
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Konferensbidrag (refereegranskat)abstract
- Energy and design of energy-feedback are becoming increasingly important in the mobile HCI community. Our application area concerns electric vehicles. We thus depart from home and workplace appliances and address range and energy anxiety caused by short driving distance capabilities and long charging times in mobile settings. While some research has been done on energy management of mobile devices, less has been done on mobility devices like electric vehicles. We explore this topic by letting conventional fuel car drivers reflect on their current driving habits through an exploration tool that we developed. Our results demonstrate three dimensions related to energy availability to consider for design of energy dependent mobility devices and provide explanations on how these dimensions could be utilize in our design through energy visualizations. With this we contributed not only by demonstrating aspects of energy availability and mobility, but also through opening up for new interesting possibilities and inquires in our and possibly other domains.
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| 18. |
- Lundström, Claes, et al.
(författare)
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Multi-Touch Table System for Medical Visualization: Application to Orthopedic Surgery Planning
- 2011
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Ingår i: IEEE Transactions on Visualization and Computer Graphics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1077-2626 .- 1941-0506. ; 17:12, s. 1775-1784
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Tidskriftsartikel (refereegranskat)abstract
- Medical imaging plays a central role in a vast range of healthcare practices. The usefulness of 3D visualizations has been demonstrated for many types of treatment planning. Nevertheless, full access to 3D renderings outside of the radiology department is still scarce even for many image-centric specialties. Our work stems from the hypothesis that this under-utilization is partly due to existing visualization systems not taking the prerequisites of this application domain fully into account. We have developed a medical visualization table intended to better fit the clinical reality. The overall design goals were two-fold: similarity to a real physical situation and a very low learning threshold. This paper describes the development of the visualization table with focus on key design decisions. The developed features include two novel interaction components for touch tables. A user study including five orthopedic surgeons demonstrates that the system is appropriate and useful for this application domain.
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| 19. |
- Lundström, Claes, et al.
(författare)
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State-of-the-art of visualization in post-mortem imaging
- 2012
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Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley-Blackwell. - 0903-4641 .- 1600-0463. ; 120:4, s. 316-326
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Forskningsöversikt (refereegranskat)abstract
- Autopsies constitute a valuable feedback to the healthcare chain to achieve improvements in quality of care and cost effectiveness. This review describes post-mortem imaging, which has emerged as an important part of the pathology toolbox. A broad range of visualization aspects within post-mortem imaging are covered. General state-of-the-art overviews of the components in the visualization pipeline are complemented by in-depth descriptions of methods developed by the authors and our collaborators. The forensic field is represented and related to, as it is spearheading much development in postmortem imaging. Other topics are workflow, imaging data acquisition, and visualization rendering technology. All in all, this review shows the mature state of visual analysis for a non-or minimal-invasive investigation of the deceased patient.
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| 20. |
- Lundström, Claes, 1973-, et al.
(författare)
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The alpha-histogram: Using Spatial Coherence to Enhance Histograms and Transfer Function Design
- 2006
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Ingår i: Proceedings Eurographics/IEEE Symposium on Visualization 2006, Lisbon, Portugal. ; , s. 227-234
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The high complexity of Transfer Function (TF) design is a major obstacle to widespread routine use of Direct Volume Rendering, particularly in the case of medical imaging. Both manual and automatic TF design schemes would benefit greatly from a fast and simple method for detection of tissue value ranges. To this end, we introduce the a-histogram, an enhancement that amplifies ranges corresponding to spatially coherent materials. The properties of the a-histogram have been explored for synthetic data sets and then successfully used to detect vessels in 20 Magnetic Resonance angiographies, proving the potential of this approach as a fast and simple technique for histogram enhancement in general and for TF construction in particular.
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| 21. |
- Lundström, Claes, 1973-, et al.
(författare)
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Uncertainty Visualization in Medical Volume Rendering Using Probabilistic Animation
- 2007
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Ingår i: IEEE Transactions on Visualization and Computer Graphics. - 1077-2626 .- 1941-0506. ; 13:6, s. 1648-1655
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Tidskriftsartikel (refereegranskat)abstract
- Direct volume rendering has proved to be an effective visualization method for medical data sets and has reached wide-spread clinical use. The diagnostic exploration, in essence, corresponds to a tissue classification task, which is often complex and time-consuming. Moreover, a major problem is the lack of information on the uncertainty of the classification, which can have dramatic consequences for the diagnosis. In this paper this problem is addressed by proposing animation methods to convey uncertainty in the rendering. The foundation is a probabilistic Transfer Function model which allows for direct user interaction with the classification. The rendering is animated by sampling the probability domain over time, which results in varying appearance for uncertain regions. A particularly promising application of this technique is a "sensitivity lens" applied to focus regions in the data set. The methods have been evaluated by radiologists in a study simulating the clinical task of stenosis assessment, in which the animation technique is shown to outperform traditional rendering in terms of assessment accuracy.
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| 22. |
- Neimane, Aleksija, et al.
(författare)
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Emergence of the Zoonotic Biliary Trematode Pseudamphistomum truncatum in Grey Seals (Halichoerus grypus) in the Baltic Sea
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:10, s. e0164782-
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Tidskriftsartikel (refereegranskat)abstract
- The biliary trematode Pseudamphistomum truncatum parasitizes a wide range of fish-eating mammals, including humans. Here we report the emergence of this parasite in grey seals (Halichoerus grypus) in the Baltic Sea. One hundred eighty-three of 1 554 grey seals (11.9%) examined from 2002–2013 had detectable hepatobiliary trematode infection. Parasite identification was confirmed as P. truncatum by sequencing the ITS2 region of a pool of five to 10 trematodes from each of ten seals collected off the coast of seven different Swedish counties. The proportion of seals parasitized by P. truncatum increased significantly over time and with increasing age of seals. Males were 3.1 times more likely to be parasitized than females and animals killed in fishery interactions were less likely to be parasitized than animals found dead or hunted. There was no significant difference in parasitism of seals examined from the Gulf of Bothnia versus those examined from the Baltic Proper. Although the majority of infections were mild, P. truncatum can cause severe hepatobiliary disease and resulted in liver failure in at least one seal. Because cyprinid fish are the second intermediate host for opisthorchiid trematodes, diets of grey seals from the Baltic Sea were analysed regarding presence of cyprinids. The proportion of gastrointestinal tracts containing cyprinid remains was ten times higher in seals examined from 2008 to 2013 (12.2%) than those examined from 2002 to 2007 (1.2%) and coincided with a general increase of trematode parasitism in the host population. The emergence and relatively common occurrence of P. truncatum in grey seals signals the presence of this parasite in the Baltic Sea ecosystem and demonstrates how aquatic mammals can serve as excellent sentinels of marine ecosystem change. Investigation of drivers behind P. truncatum emergence and infection risk for other mammals, including humans, is highly warranted.
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| 23. |
- Sönnerfors, Pernilla, et al.
(författare)
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The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish CArdiopulmonary bioImage study (SCAPIS) cohort.
- 2024
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Ingår i: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 11:1, s. 2372903-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A substantial proportion of individuals with COPD have never smoked, and it is implied to be more common than previously anticipated but poorly studied.AIM: To describe the process of recruitment of never-smokers with COPD from a population-based cohort (n = 30 154).METHODS: We recruited never-smokers with COPD, aged 50-75 years, from six University Hospitals, based on: 1) post broncho-dilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) < 0.70 and 2) FEV1 50-100% of predicted value and 3) being never-smokers (self-reported). In total 862 SCAPIS participants were identified, of which 652 were reachable and agreed to a first screening by telephone. Altogether 128 (20%) were excluded due to previous smoking or declined participation. We also applied a lower limit of normal (LLN) of FEV1/FVC (z-score<-1.64) according to the Global Lung Initiative to ensure a stricter definition of airflow obstruction.RESULTS: Data on respiratory symptoms, health status, and medical history were collected from 492 individuals, since 32 were excluded at a second data review (declined or previous smoking), prior to the first visit. Due to not matching the required lung function criteria at a second spirometry, an additional 334 (68%) were excluded. These exclusions were by reason of: FEV1/FVC ≥0.7 (49%), FEV1 > 100% of predicted (26%) or z-score ≥ -1,64 (24%). Finally, 154 never-smokers with COPD were included: 56 (36%) women, (mean) age 60 years, FEV1 84% of predicted, FEV1/FVC: 0.6, z-score: -2.2, Oxygen saturation: 97% and BMI: 26.8 kg/m2.CONCLUSIONS: The challenges of a recruitment process of never-smokers with COPD were shown, including the importance of correct spirometry testing and strict inclusion criteria. Our findings highlight the importance of repeated spirometry assessments for improved accuracy in diagnosing COPD.
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| 24. |
- Ynnerman, Anders, 1963-, et al.
(författare)
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Multi-Touch Table System for Medical Visualization
- 2015
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Ingår i: Eurographics 2015. - : Eurographics - European Association for Computer Graphics.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Medical imaging plays a central role in a vast range of healthcare practices. While the usefulness of 3D visualizations is well known, the adoption of such technology has previously been limited in many medical areas. This paper, awarded the Dirk Bartz Prize for Visual Computing in Medicine 2015, describes the development of a medical multi-touch visualization table that successfully has reached its aim to bring 3D visualization to a wider clinical audience. The descriptions summarize the targeted clinical scenarios, the key characteristics of the system, and the user feedback obtained.
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| 25. |
- Ahlbom, Anders, et al.
(författare)
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Den åldrande befolkningen
- 2010
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 107:48, s. 3048-3051
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Tidskriftsartikel (refereegranskat)
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| 26. |
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| 27. |
- Allerbo, Oskar, et al.
(författare)
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Simulations of Lipid Vesicle Rupture Induced by an Adjacent Supported Lipid Bilayer Patch
- 2011
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Ingår i: Colloids and Surfaces B. - : Elsevier BV. - 0927-7765 .- 1873-4367. ; 82, s. 632-636
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Tidskriftsartikel (refereegranskat)abstract
- Using a simple phenomenological model of a lipid bilayer and a surface, simulations were performed to study the bilayer-induced vesicle rupture probability as a vesicle adsorbs adjacently to a bilayer patch already adsorbed on the surface. The vesicle rupture probability was studied as a function of temperature, vesicle size, and surface-bilayer interaction strength. From the simulation data, estimates of the apparent activation energy for bilayer-induced vesicle rupture were calculated, both for different vesicle sizes and for different surface-bilayer interaction strengths.
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| 28. |
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Allusions and Reflections : Greek and Roman Mythology in Renaissance Europe
- 2015
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- In June 2012, scholars from a number of disciplines and countries gathered in Stockholm to discuss the representation of ancient mythology in Renaissance Europe. This symposium was an opportunity for the participants to cross disciplinary borders and to problematize a well-researched field. The aim was to move beyond a view of mythology as mere propaganda in order to promote an understanding of ancient tales and fables as contemporary means to explain and comprehend the Early Modern world.With the Renaissance, pagan religion ceased to pose a threat to Christianity and its mythologies found a way to coexist with Christian doctrine. Old Greek and Roman tales came to play a crucial role in Renaissance culture, partly because the ancient sources, both literary and artistic, many of them recently uncovered, provided rich material for the writers and artists of the period. Mythology provided a network of allusions and references for contemporary poetry and art, reinforcing the possibilities of allegorical interpretation. Furthermore, it offered moral guidance since deities could easily be materialized into personifications of vices and virtues. All artistic expressions, visual and textual, whether they belonged to a secular or a religious tradition, made use of mythology. This volume exemplifies how Renaissance writers’ and artists’ acquaintance with mythological accounts from Homer to Apuleius was of utmost importance for their creative work, as it was for their readers and those contemporary patrons of art who saw themselves as the living embodiment of some remote ancient deity. By posing new questions and suggesting alternative answers to old ones, the contributors to this volume provide a better and more detailed understanding of the struggles and strategies of recycling, recuperating and transforming ancient mythology during the Renaissance. All chapters here have a common focus on the re-configuration of classical myths in Early Modern Europe, in political, erotic and ceremonial contexts. By returning to the classical world of cosmic strife and harmony, of gods and metamorphoses, Renaissance poets and artists were able to express their aesthetic ideals, personal preoccupations and moral attitudes. Ancient mythology offered them a full set of useful metaphors, which could take on new meanings in a new cultural context.
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| 29. |
- Andersson, Anders, et al.
(författare)
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Describing fish passage in a river confluence with telemetry and CFD
- 2016
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Konferensbidrag (refereegranskat)abstract
- The confluence between hydropower tailrace and the old river bed in Stornorrfors in the river Umeälven in the northern part of Sweden has shown to be the largest obstacle for upstream migrating salmon and sea trout during the migrating season. Fish are attracted to the high flow rate from the tailrace and will not migrate upstream in the old river bed being the passage to the fishway leading past the hydropower dam. By triangulating the movements of radio tagged fish using eight antennas in the confluence, it is here possible to describe the individual fish tracks left by radio tagged fish during the migrating season. These tracks are then compared with three-dimensional Computational Fluid Dynamics (CFD) simulations of the confluence. By simulating the most common combinations of turbine flow and spill flow in the old river bed it is then possible to find correlations between individual fish movements and flow parameters such as velocity, turbulence intensity or vorticity for different flow combinations. It was previously assumed that fish had trouble locating the old river bed, the results of the triangulation however shows that most fish finds the old river bed within a few days but does not chose to migrate until several days (or weeks) later. The main issue to be solved is therefore not how to attract the fish to the old river bed but rather how to create favorable conditions in the old river bed so that migrating fish are more inclined to take that path upstream.
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| 30. |
- Andersson, Anders G., et al.
(författare)
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A numerical study of the location and function of the entrance of a fishway in a regulated river
- 2010
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Ingår i: 8th International Symposium on ECOHYDRAULICS. ; , s. 277-284
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Konferensbidrag (refereegranskat)abstract
- Simulation driven design with Computational Fluid Dynamics has been used to evaluate the flow downstream a hydropower plant with regards to upstream migrating fish. Field measurements with an Acoustic Doppler Current Profiler were performed and the measurements were used to validate the simulations. The measurements indicate a more unstable flow than the simulations and the tailrace jet from the turbines is stronger in the simulations. The simulations are however considered to capture the important features of the flow in a way that makes them viable for attraction water simulations. A fishway entrance was included in the simulations and the subsequent attraction water was evaluated for two positions and two angles of the entrance at different turbine discharges. Results show that both positions are viable and that a position where the flow from the fishway does not have to compete with the flow from the power plant will generate superior attraction water. Simulations were also performed further downstream where the flow from the turbines meets the old river bed which is the current fish passage for upstream migrating fish. A modification of the old river bed was made in the model as one scenario to generate better attraction water. This considerably increases the attraction water although it cannot compete with the flow from the tailrace tunnel.
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| 31. |
- Andersson, Anders G., et al.
(författare)
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A study of the location of the entrance of a fishway in a regulated river with CFD and ADCP
- 2012
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Ingår i: Modelling and Simulation in Engineering. - : Hindawi Limited. - 1687-5591 .- 1687-5605. ; 2012
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Tidskriftsartikel (refereegranskat)abstract
- Simulation-driven design with computational fluid dynamics has been used to evaluate the flow downstream of a hydropower plant with regards to upstream migrating fish. Field measurements with an Acoustic Doppler Current Profiler were performed, and the measurements were used to validate the simulations. The measurements indicate a more unstable flow than the simulations, and the tailrace jet from the turbines is stronger in the simulations. A fishway entrance was included in the simulations, and the subsequent attraction water was evaluated for two positions and two angles of the entrance at different turbine discharges. Results show that both positions are viable and that a position where the flow from the fishway does not have to compete with the flow from the power plant will generate superior attraction water. Simulations were also performed for further downstream where the flow from the turbines meets the old river bed which is the current fish passage for upstream migrating fish. A modification of the old river bed was made in the model as one scenario to generate better attraction water. This considerably increases the attraction water although it cannot compete with the flow from the tailrace tunnel.
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| 32. |
- Andersson, Anders G., et al.
(författare)
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CFD-modell av turbinutloppet i Stornorrfors
- 2009
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Ingår i: Svenska mekanikdagarna. - Stockholm : Svenska nationalkommittén för mekanik. ; , s. 106-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 33. |
- Andersson, Anders G., et al.
(författare)
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CFD-modelling and validation of free surface flow during spilling of reservoir in down-scale model
- 2013
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Ingår i: Engineering Applications of Computational Fluid Mechanics. - : Informa UK Limited. - 1994-2060 .- 1997-003X. ; 7:1, s. 159-167
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Tidskriftsartikel (refereegranskat)abstract
- Fully three dimensional modelling of the spilling from a reservoir with relatively complex geometry were performed and compared to experimental results from a physical scale model with the aim to advance the science of numerical modelling of free surface flow of real reservoirs. In the set-up in focus the water was spilled from the reservoir through three gates that could be manoeuvred separately. In the first case two of the gates were closed and the third gate was partly opened. In this experimental set-up the water surface in the reservoir was close to horizontal. Therefore it was here meaningful to compare a rigid lid modelling approximation to the more computational heavy method of Volume of Fluids. In the second case, all three gates were open, resulting in a nonhorizontal varied flow surface profile in the reservoir upstream critical sections at the spillway crests. This case was simulated with Volume of Fluids and the position of the air-water interface was derived for two turbulence models, the standard k-ε and SSG. Water levels, velocities and the shape of the water surface were compared to experiments. The simulation results capture qualitative features such as a vortex near the outlet and show good quantitative agreement with the experiments regardless of method used to simulate the free surface. In general, simulations with the standard k-ε and the more advanced SSG turbulence models give the same results with respect to the averaged quantities measured.
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| 34. |
- Andersson, Anders G., et al.
(författare)
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Effect of spatial resolution of rough surfaces on numerically computed flow fields with application to hydraulic engineering
- 2014
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Ingår i: Engineering Applications of Computational Fluid Mechanics. - : Informa UK Limited. - 1994-2060 .- 1997-003X. ; 8:3, s. 373-381
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Tidskriftsartikel (refereegranskat)abstract
- In numerical simulations of flow over rough surfaces, the roughness is often not resolved but represented by a numerical model. The validity of such an assumption is investigated in this paper by Reynolds-Averaged Navier-Stokes simulations of flow over a surface with a large roughness. The surface was created from a high-resolution laser scanning of a real rock blasted tunnel. By reducing the geometrical resolution of the roughness in two steps, the importance of an appropriate surface description could be examined. The flow fields obtained were compared to a set-up with a geometrical flat surface where the roughness was represented by a modified form of the Launder and Spalding wall-function. The flow field over the surface with the lowest resolution was substantially different from those of the two finer resolutions and rather close to the results from the set-up with the wall-function. The results also yield that the finer the resolution is the more vorticity is formed close to the rough surface and more turbulence is generated.
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| 35. |
- Andersson, Anders G., et al.
(författare)
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Flow through a two-scale porosity material
- 2009
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Ingår i: Research Letters in Materials Science. - : Hindawi Limited. - 1687-6822 .- 1687-6830.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Flow through a two-scale porous medium is here investigated by a unique comparison between simulations performed with computational fluid dynamics and the boundary element method with microparticle image velocimetry in model geometries.
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| 36. |
- Andersson, Anders G., et al.
(författare)
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Fluid flow through porous media with dual scale porosity
- 2008
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Ingår i: Proceedings of the 19th International Symposium on Transport Phenomena (ISTP-19). - : University of Iceland, Faculty of Industrial Engineering, Mechanical Engineering and Computer Science.
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Konferensbidrag (refereegranskat)abstract
- Flow in two scale porous media takes place in applications such as advanced composites manufacturing. Knowledge of this flow is of general importance and is crucial for filtration mechanisms when functional filler-particles are added to the liquid resin impregnating the fibrous preform. Means to model and experimentally visualise this flow is here investigated. In particular simulations performed with computational fluid dynamics and the boundary element method are compared to micro particle image velocimetry in a model geometry.
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| 37. |
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| 38. |
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| 39. |
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| 40. |
- Andersson, L. Robin, et al.
(författare)
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Characterization of Flow Structures Induced by Highly Rough Surface Using Particle Image Velocimetry, Proper Orthogonal Decomposition and Velocity Correlations
- 2018
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Ingår i: Engineering. - : Scientific Research Publishing. - 1947-3931 .- 1947-394X. ; 10, s. 399-416
-
Tidskriftsartikel (refereegranskat)abstract
- High Reynolds number flow inside a channel of rectangular cross section is examined using Particle Image Velocimetry. One wall of the channel has been replaced with a surface of a roughness representative to that of real hydropower tunnels, i.e. a random terrain with roughness dimensions typically in the range of ≈10% - 20% of the channels hydraulic radius. The rest of the channel walls can be considered smooth. The rough surface was captured from an existing blasted rock tunnel using high resolution laser scanning and scaled to 1:10. For quantification of the size of the largest flow structures, integral length scales are derived from the auto-correlation functions of the temporally averaged velocity. Additionally, Proper Orthogonal Decomposition (POD) and higher-order statistics are applied to the instantaneous snapshots of the velocity fluctuations. The results show a high spatial heterogeneity of the velocity and other flow characteristics in vicinity of the rough surface, putting outer similarity treatment into jeopardy. Roughness effects are not confined to the vicinity of the rough surface but can be seen in the outer flow throughout the channel, indicating a different behavior than postulated by Townsend’s similarity hypothesis. The effects on the flow structures vary depending on the shape and size of the roughness elements leading to a high spatial dependence of the flow above the rough surface. Hence, any spatial averaging, e.g. assuming a characteristic sand grain roughness factor, for determining local flow parameters becomes less applicable in this case.
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| 41. |
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| 42. |
-
Arbete pågår : - i tankens mönster och kroppens miljöer
- 2008
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Work is always in progress, somewhere, in some form. In a historical perspective the view of work has changed, as have the contexts where work takes place. Still there are strongly rooted images of what work is – in the patterns of thought and material conditions.This book embarks from the idea that work is something both immaterial and material. It discusses work as a conception and cultural norm, but also as something very tangible and concrete.Researchers from an array of scientific fields have gathered together around these questions. The idea has been to twist and turn the conceptions of what work is and – embarking from one’s own discipline – to contribute new perspectives to this topic.
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| 43. |
- Artman, Henrik, 1968-, et al.
(författare)
-
Effektiv miljötillsyn : slutrapport
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Målsättningen har varit att ta fram ny kunskap inom miljötillsynen och därigenom uppnå en effektivare miljötillsyn samt att få in nya vetenskapliga perspektiv på miljötillsyn.I rapporten studeras metoder för inspektioner och det kommunikativa samspelet mellan inspektören och företrädare för den verksamhet som inspekteras, hur den institutionella ramen för inspektionsprocessen fungerar samt visar på möjligheter att mäta effekterna av inspektioner och tillsyn.Naturvårdsverket kommer att ha resultatet som ett kunskapsunderlag i fortsatt arbete med tillsynsvägledning och utveckling av hur tillsyn och tillsynsvägledning kan följas upp och utvärderas.
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| 44. |
- Artzén, Ditte, et al.
(författare)
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Capsule complication during cataract surgery: Case-control study of preoperative and intraoperative risk factors: Swedish Capsule Rupture Study Group report 2.
- 2009
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Ingår i: Journal of cataract and refractive surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0886-3350 .- 1873-4502. ; 35:10, s. 1688-1693
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Tidskriftsartikel (refereegranskat)abstract
- Abstract PURPOSE: To identify preoperative and intraoperative factors associated with a capsule complication; that is, a capsule tear or a zonular dehiscence during cataract surgery. SETTING: Ten ophthalmic surgery departments in Sweden. METHODS: A retrospective review of files of patients with a capsule complication and control patients with no complication operated on in 2003 was performed. RESULTS: The review comprised 324 patients with a capsule complication and 331 control patients. In the logistic regression analyses, preoperative conditions associated with a capsule complication were previous trauma, white and brunescent/hard cataract, and phacodonesis. The intraoperative factors of loose zonules, the use of trypan blue, and miosis were all statistically significantly overrepresented in the capsule complication group. The same was true for eyes operated on by surgeons with the least experience. CONCLUSIONS: By preoperatively identifying cataract cases with the identified risk factors and allocating them to surgeons with the longest experience, the number of capsule complications could be kept low. Operating early in the course of the disease to prevent the cataract from becoming a poor surgical risk and improving training of junior surgeons should further reduce the frequency of capsule complications.
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| 45. |
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| 46. |
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| 47. |
- Athanassiadis, Dimitris, et al.
(författare)
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HARVESTING POTENTIAL AND PROCUREMENT COSTS OF LOGGING RESIDUES IN SWEDEN
- 2009
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study was (i) to provide an estimation of the potential amount of logging residues (branches, tops and stumps with attached root system) that will be produced in Sweden (thinning and regeneration fellings) during the next decade (2010-2019) and (ii) calculate the costs for harvesting the residue, comminute it and bring it to the end user. Depending on the level of ecological, technical and economical restrictions the potential amount of slash (branches, tops and stumps) in regeneration fellings varied from 3.2 to 7.4 Mt OD annually while the potential amount (Mt OD) of stumps varied from 4.2 to 11.7 annually. The corresponding annual figures in thinning for slash and stumps were 1.7 to 3.9 and 1.8 to 5.7 Mt OD annually, respectively. 80% of the potential amount of slash and stumps at level 3 of ecological, technical and economical restrictions in regeneration fellings would be available for 85 EUR/ODT and 110 EUR/ODT, respectively
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| 48. |
- Athanassiadis, Dimitris, et al.
(författare)
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Is there enough primary forest fuel available to feed into the existing and planned CHP facilities? The case of Northern Sweden
- 2010
-
Ingår i: Publications / FINBIO. - 1239-4874. ; , s. 77-83
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Konferensbidrag (refereegranskat)abstract
- A combined GIS and optimization method was used to calculate logging residue (slash and stumps) flows and expected costs at the heating or combined heat and power plants (CHP) in Northern Sweden for two logging residue supply chains. Regional primary forest energy availability was estimated considering ecological, technical and economical restrictions. Two supply chains were considered: One supply chain was based on truck transport of the fuel to the CHP plants and the other one was based on collecting the fuel to terminals adjacent to railway lines and transporting it by train to plants that are located in Central Sweden. The costs for each supply chain were calculated based on current costs for harvesting, forwarding, chipping/crushing, machine allocation to the harvesting site, road transport, compensation to the land owner and administration. The lowest cost pathway to the plants was selected. The effects of the establishment of the CHP plants on regional development are discussed
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| 49. |
- Athanassiadis, Dimitris, et al.
(författare)
-
Marginalkostnader för skörd av grot och stubbar från föryngringsavverkningar i Sverige
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Kostnaden för att ta ut grot och stubbar från föryngringsavverkningar i Sverige har uppskattats och redovisas i form av marginalkostnadskurvor. Beräkningarna baseras på den mängd grot och stubbar som faller ut till följd av föryngringsavverkningar som utförs i referensscenariot i SKA-VB 08 för perioden 2010 - 2019. De potentialer som använts är efter avdrag för ekologiska, tekniska och ekonomiska restriktioner, dvs. nivå 3 i SKA-VB 08. Kostnaderna för uttag av grot och stubbar har beräknats för de maskinsystem som är vanligast förekommande i Sverige och Finland idag. Ersättning till markägare, administrationsomkostnader och kostnader för skörd, sönderdelning, maskinflyttningar och transport av grot och stubbar är de kostnadsposter som ingår i beräkningarna. Grot kan tas ut till en lägre kostnad än stubbar vilket leder till att marginalkostnadskurvan för grot startar på en lägre nivå än marginalkostnadskurvan för stubbar; 600 kr/ton TS för grot respektive 800 kr/ton TS för stubbar. Om kostnaden får öka från 770 till 920 kr/ton TS kan tillvaratagandet av grot öka från dagens ca 2 till 2,9 Mton TS, dvs. 90 % av den tillgängliga potentialen som är 3,2 Mton TS. Först vid en kostnad på 850 kr/ton TS trädbränsle uppgår andelen stubbar till 10 % av sortimentsfördelningen. Vid en kostnad på 1 100 kr/ton TS är sortimentsfördelningen så gott som lika för grot och stubbar. Om 2,5 Mton TS (60 %) av tillgänglig potential stubbar i nuläget ska bli aktuella för skörd blir uttagskostnaden upp till 1 000 kr/ton TS. Omräkningstalet 1 ton TS = 4,9 MWh har använts vid omvandling mellan massa och energi. Detta värde anger mängden energi som kan avges som värme vid förbränning av skogsbränsle med en fukthalt på 40 % när vattnets ångbildningsenergi inte utnyttjas. Om prestationen för de maskiner som ingår i stubbsystemet ökar med 15 % så kan man få ut samma mängd vid 920 kr/ton TS. Kostnadsfördelningen visar att transportkostnaderna är den viktigaste kostnadsposten, speciellt när det gäller små avverkningstrakter, belägna långt från tätort
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| 50. |
- Athanassiadis, Dimitris, et al.
(författare)
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Procurement costs of slash and stumps in Sweden – a comparison between South and North Sweden
- 2010
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Marginal cost curves were used to appreciate the amount of slash and stumps that could be harvested at certain costs in Sweden as a whole as well as in two regions (Upper Norrland and South Sweden). The expected region specific variations were quantified and region specific estimates on harvestable potentials of stumps and slash were made. The results in this work were based on data collected in the Swedish Forest Inventory (SFI) from 2002 to 2006
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